locus-tag	class	description
SMN_RS00010	COG0592	DNA-directed DNA polymerase activity
SMN_RS00015	COG0187	DNA topoisomerase II activity
SMN_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMN_RS00040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMN_RS00045	COG2203	Gaf domain
SMN_RS00045	COG3706	GGDEF domain
SMN_RS00045	COG4251	negative regulation of phosphorylation
SMN_RS00045	COG5001	Diguanylate cyclase
SMN_RS00055	COG4175	Glycine betaine
SMN_RS00060	COG4176	ABC-type proline glycine betaine transport system permease component
SMN_RS00065	COG2113	Glycine betaine
SMN_RS00070	COG2814	Major facilitator Superfamily
SMN_RS00080	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SMN_RS00090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMN_RS00095	COG0066	3-isopropylmalate dehydratase activity
SMN_RS00155	COG3328	transposase activity
SMN_RS00220	COG0840	transmembrane signaling receptor activity
SMN_RS00245	COG2801	Transposase and inactivated derivatives
SMN_RS00255	COG0745	RESPONSE REGULATOR receiver
SMN_RS00260	COG3328	transposase activity
SMN_RS00280	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SMN_RS00295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMN_RS00300	COG1335	isochorismatase
SMN_RS00315	COG2207	Transcriptional regulator
SMN_RS00320	COG1053	succinate dehydrogenase
SMN_RS00325	COG0039	L-malate dehydrogenase activity
SMN_RS00330	COG0045	succinate-CoA ligase (ADP-forming) activity
SMN_RS00345	COG1355	regulation of microtubule-based process
SMN_RS00370	COG2169	Transcriptional regulator
SMN_RS00370	COG1917	Cupin 2, conserved barrel domain protein
SMN_RS00380	COG3150	esterase
SMN_RS00385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMN_RS00395	COG3383	formate dehydrogenase (NAD+) activity
SMN_RS00450	COG2095	MarC family integral membrane protein
SMN_RS00470	COG1120	ATPase activity
SMN_RS00475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMN_RS00510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMN_RS00515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMN_RS00520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMN_RS00540	COG1328	CTP reductase activity
SMN_RS00540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMN_RS00545	COG1794	racemase activity, acting on amino acids and derivatives
SMN_RS00550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMN_RS00555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMN_RS00560	COG0564	pseudouridine synthase activity
SMN_RS00565	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMN_RS00570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMN_RS00580	COG0107	imidazoleglycerol-phosphate synthase activity
SMN_RS00590	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SMN_RS00595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SMN_RS00595	COG0517	IMP dehydrogenase activity
SMN_RS00600	COG1187	pseudouridine synthase activity
SMN_RS00605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMN_RS00605	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMN_RS00615	COG2257	FlhB HrpN YscU SpaS Family
SMN_RS00625	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMN_RS00630	COG0237	dephospho-CoA kinase activity
SMN_RS00635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMN_RS00645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMN_RS00650	COG0268	Binds directly to 16S ribosomal RNA
SMN_RS00665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMN_RS00670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMN_RS00680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMN_RS00685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMN_RS00690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMN_RS00695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMN_RS00700	COG0348	domain, Protein
SMN_RS00710	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SMN_RS00725	COG0754	glutathionylspermidine amidase activity
SMN_RS00740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMN_RS00770	COG0642	Histidine kinase
SMN_RS00775	COG0745	RESPONSE REGULATOR receiver
SMN_RS00790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SMN_RS00795	COG1127	ABC transporter
SMN_RS00800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMN_RS00810	COG2095	MarC family integral membrane protein
SMN_RS00865	COG0004	ammonium transporteR
SMN_RS00880	COG0667	Aldo Keto reductase
SMN_RS00890	COG0745	RESPONSE REGULATOR receiver
SMN_RS00905	COG0765	amino acid transport
SMN_RS00930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMN_RS00935	COG1121	(ABC) transporter
SMN_RS00955	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SMN_RS00965	COG0318	PFAM AMP-dependent synthetase and ligase
SMN_RS00970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMN_RS00975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS00980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS00985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS00990	COG0649	NAD binding
SMN_RS01010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMN_RS01015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS01020	COG0839	Belongs to the complex I subunit 6 family
SMN_RS01025	COG0713	ATP synthesis coupled electron transport
SMN_RS01030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMN_RS01035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS01040	COG1007	ATP synthesis coupled electron transport
SMN_RS01050	COG1012	belongs to the aldehyde dehydrogenase family
SMN_RS01055	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMN_RS01075	COG0840	transmembrane signaling receptor activity
SMN_RS01085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMN_RS01090	COG0303	'Molybdopterin
SMN_RS01100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMN_RS01105	COG0254	rRNA binding
SMN_RS01110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SMN_RS01130	COG0436	Aminotransferase
SMN_RS01135	COG0460	homoserine dehydrogenase
SMN_RS01140	COG0792	nuclease activity
SMN_RS01145	COG3118	belongs to the thioredoxin family
SMN_RS01150	COG0492	ferredoxin-NADP+ reductase activity
SMN_RS01155	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMN_RS01160	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMN_RS01165	COG1242	4 iron, 4 sulfur cluster binding
SMN_RS01180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMN_RS01180	COG0140	phosphoribosyl-ATP diphosphatase activity
SMN_RS01195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SMN_RS01205	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMN_RS01210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMN_RS01215	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMN_RS01220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMN_RS01225	COG1077	Cell shape determining protein MreB Mrl
SMN_RS01235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMN_RS01260	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMN_RS01265	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SMN_RS01270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMN_RS01295	COG4974	Belongs to the 'phage' integrase family
SMN_RS01310	COG2963	transposase activity
SMN_RS01315	COG2801	Transposase and inactivated derivatives
SMN_RS01320	COG3328	transposase activity
SMN_RS01325	COG2801	Transposase and inactivated derivatives
SMN_RS01355	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS01360	COG0243	molybdopterin cofactor binding
SMN_RS01380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMN_RS01385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMN_RS01395	COG0835	chemotaxis
SMN_RS01395	COG0784	Response regulator, receiver
SMN_RS01400	COG0784	Response regulator, receiver
SMN_RS01400	COG0643	Histidine kinase
SMN_RS01400	COG2198	Histidine kinase
SMN_RS01405	COG0835	chemotaxis
SMN_RS01415	COG0560	Phosphoserine phosphatase
SMN_RS01450	COG0193	aminoacyl-tRNA hydrolase activity
SMN_RS01460	COG0019	diaminopimelate decarboxylase activity
SMN_RS01465	COG0077	Prephenate dehydratase
SMN_RS01465	COG1605	Chorismate mutase
SMN_RS01470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMN_RS01480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMN_RS01490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMN_RS01500	COG0450	alkyl hydroperoxide reductase
SMN_RS01505	COG0840	transmembrane signaling receptor activity
SMN_RS01515	COG0105	UTP biosynthetic process
SMN_RS01525	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMN_RS01535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMN_RS01540	COG0287	Prephenate dehydrogenase
SMN_RS01545	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMN_RS01550	COG0248	Ppx GppA phosphatase
SMN_RS01555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_RS01565	COG0745	RESPONSE REGULATOR receiver
SMN_RS01575	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMN_RS01585	COG0157	Belongs to the NadC ModD family
SMN_RS01590	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMN_RS01605	COG0850	regulation of cytokinetic process
SMN_RS01610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SMN_RS01620	COG0083	homoserine kinase activity
SMN_RS01640	COG0779	Required for maturation of 30S ribosomal subunits
SMN_RS01645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMN_RS01645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMN_RS01655	COG5001	Diguanylate cyclase
SMN_RS01665	COG5002	protein histidine kinase activity
SMN_RS01680	COG3258	Cytochrome c
SMN_RS01690	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SMN_RS01690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMN_RS01705	COG0243	molybdopterin cofactor binding
SMN_RS01710	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS01715	COG3301	Polysulphide reductase, NrfD
SMN_RS01720	COG2199	diguanylate cyclase activity
SMN_RS01720	COG2200	EAL domain
SMN_RS01720	COG3287	FIST C domain
SMN_RS01730	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS01735	COG3301	Polysulphide reductase, NrfD
SMN_RS01740	COG0745	RESPONSE REGULATOR receiver
SMN_RS01745	COG5002	protein histidine kinase activity
SMN_RS01755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMN_RS01765	COG1227	inorganic diphosphatase activity
SMN_RS01785	COG1570	exodeoxyribonuclease VII activity
SMN_RS01805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMN_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
SMN_RS01815	COG2207	Transcriptional regulator
SMN_RS01820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMN_RS01825	COG0583	DNA-binding transcription factor activity
SMN_RS01830	COG2855	membrane
SMN_RS01835	COG0386	Belongs to the glutathione peroxidase family
SMN_RS01855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMN_RS01865	COG0402	S-adenosylhomocysteine deaminase activity
SMN_RS01870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMN_RS01875	COG0006	proline dipeptidase activity
SMN_RS01880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMN_RS01885	COG1419	protein localization to endoplasmic reticulum
SMN_RS01890	COG0455	bacterial-type flagellum organization
SMN_RS01900	COG1191	sigma factor activity
SMN_RS01905	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMN_RS01910	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMN_RS01910	COG1776	CheC inhibitor of MCP methylation
SMN_RS01915	COG1611	Belongs to the LOG family
SMN_RS01925	COG0463	Glycosyl transferase, family 2
SMN_RS01935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMN_RS01940	COG2076	Multidrug Resistance protein
SMN_RS01955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMN_RS01965	COG1040	competence protein
SMN_RS01995	COG2204	response regulator
SMN_RS02000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMN_RS02010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SMN_RS02015	COG0731	radical SAM domain protein
SMN_RS02025	COG2358	TRAP transporter, solute receptor (TAXI family
SMN_RS02035	COG0582	viral genome integration into host DNA
SMN_RS02060	COG3328	transposase activity
SMN_RS02090	COG3328	transposase activity
SMN_RS02185	COG0419	ATPase involved in DNA repair
SMN_RS02195	COG3328	transposase activity
SMN_RS02220	COG0039	L-malate dehydrogenase activity
SMN_RS02230	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SMN_RS02235	COG1834	amidinotransferase
SMN_RS02245	COG0693	protein deglycase activity
SMN_RS02275	COG3287	FIST C domain
SMN_RS02275	COG2199	diguanylate cyclase activity
SMN_RS02275	COG2200	EAL domain
SMN_RS02290	COG3118	belongs to the thioredoxin family
SMN_RS02300	COG4336	lyase activity
SMN_RS02325	COG4628	conserved protein (DUF2132)
SMN_RS02330	COG4221	oxidoreductase activity
SMN_RS02345	COG0683	leucine binding
SMN_RS02370	COG1012	belongs to the aldehyde dehydrogenase family
SMN_RS02385	COG3022	response to hydroperoxide
SMN_RS02410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMN_RS02415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMN_RS02430	COG0250	Participates in transcription elongation, termination and antitermination
SMN_RS02435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMN_RS02440	COG0081	regulation of translation
SMN_RS02445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMN_RS02450	COG0222	ribosome binding
SMN_RS02455	COG0085	RNA polymerase activity
SMN_RS02460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMN_RS02465	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMN_RS02475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMN_RS02485	COG2011	ABC-type metal ion transport system permease component
SMN_RS02490	COG1464	Belongs to the NlpA lipoprotein family
SMN_RS02505	COG1522	sequence-specific DNA binding
SMN_RS02510	COG0697	spore germination
SMN_RS02525	COG0534	Mate efflux family protein
SMN_RS02540	COG0745	RESPONSE REGULATOR receiver
SMN_RS02555	COG0840	transmembrane signaling receptor activity
SMN_RS02560	COG0840	transmembrane signaling receptor activity
SMN_RS02570	COG1034	ATP synthesis coupled electron transport
SMN_RS02575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMN_RS02580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS02585	COG0839	Belongs to the complex I subunit 6 family
SMN_RS02590	COG0713	ATP synthesis coupled electron transport
SMN_RS02595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMN_RS02600	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS02605	COG1007	ATP synthesis coupled electron transport
SMN_RS02625	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS02625	COG0649	NAD binding
SMN_RS02630	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS02635	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS02650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMN_RS02670	COG0357	Ribosomal RNA small subunit methyltransferase G
SMN_RS02675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMN_RS02680	COG1970	mechanosensitive ion channel activity
SMN_RS02690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMN_RS02695	COG0113	porphobilinogen synthase activity
SMN_RS02700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMN_RS02710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMN_RS02715	COG0247	lactate metabolic process
SMN_RS02740	COG2026	Addiction module toxin, RelE StbE family
SMN_RS02745	COG3706	GGDEF domain
SMN_RS02750	COG2814	Major facilitator Superfamily
SMN_RS02755	COG3012	SEC-C Motif Domain Protein
SMN_RS02770	COG3706	GGDEF domain
SMN_RS02775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMN_RS02785	COG1053	succinate dehydrogenase
SMN_RS02790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMN_RS02800	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SMN_RS02805	COG0628	permease
SMN_RS02810	COG2255	four-way junction helicase activity
SMN_RS02815	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMN_RS02825	COG0159	tryptophan synthase activity
SMN_RS02845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMN_RS02850	COG1136	(ABC) transporter
SMN_RS02855	COG1684	flagellar biosynthetic protein fliR
SMN_RS02865	COG0194	GDP metabolic process
SMN_RS02870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMN_RS02875	COG0018	arginyl-trna synthetase
SMN_RS02885	COG2199	diguanylate cyclase activity
SMN_RS02885	COG2200	EAL domain
SMN_RS02885	COG3287	FIST C domain
SMN_RS02900	COG0735	belongs to the Fur family
SMN_RS02910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMN_RS02915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMN_RS02925	COG0149	triose-phosphate isomerase activity
SMN_RS02930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMN_RS02940	COG0195	Participates in both transcription termination and antitermination
SMN_RS02975	COG0037	tRNA processing
SMN_RS02980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMN_RS02985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMN_RS02990	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMN_RS03015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMN_RS03020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SMN_RS03025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMN_RS03035	COG1151	hydroxylamine reductase activity
SMN_RS03065	COG2326	polyphosphate kinase activity
SMN_RS03090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMN_RS03100	COG1981	membrane
SMN_RS03105	COG0513	Belongs to the DEAD box helicase family
SMN_RS03110	COG2610	gluconate transmembrane transporter activity
SMN_RS03115	COG1944	ATP diphosphatase activity
SMN_RS03145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SMN_RS03160	COG2361	Protein of unknown function DUF86
SMN_RS03230	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMN_RS03250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMN_RS03250	COG1333	cytochrome c biogenesis protein
SMN_RS03290	COG1058	Belongs to the CinA family
SMN_RS03290	COG1546	Belongs to the CinA family
SMN_RS03295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMN_RS03305	COG0516	GMP reductase activity
SMN_RS03305	COG0517	IMP dehydrogenase activity
SMN_RS03310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMN_RS03325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMN_RS03330	COG0436	Aminotransferase
SMN_RS03345	COG1193	negative regulation of DNA recombination
SMN_RS03350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMN_RS03355	COG0251	oxidation-reduction process
SMN_RS03360	COG0579	oxidoreductase
SMN_RS03375	COG0454	-acetyltransferase
SMN_RS03375	COG0456	acetyltransferase
SMN_RS03380	COG3409	Peptidoglycan-binding domain 1 protein
SMN_RS03380	COG0793	Belongs to the peptidase S41A family
SMN_RS03390	COG0469	pyruvate kinase activity
SMN_RS03395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMN_RS03400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMN_RS03405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMN_RS03410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMN_RS03415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMN_RS03425	COG1192	Involved in chromosome partitioning
SMN_RS03430	COG1475	DNA binding
SMN_RS03440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMN_RS03445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMN_RS03455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMN_RS03470	COG0811	peptide transport
SMN_RS03475	COG0848	biopolymer transport protein
SMN_RS03485	COG0823	Involved in the tonB-independent uptake of proteins
SMN_RS03500	COG1047	Peptidyl-prolyl cis-trans
SMN_RS03510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMN_RS03515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMN_RS03520	COG0037	tRNA processing
SMN_RS03530	COG0067	glutamate synthase
SMN_RS03530	COG0070	glutamate synthase
SMN_RS03530	COG0069	glutamate synthase activity
SMN_RS03535	COG0493	'glutamate synthase
SMN_RS03545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMN_RS03550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMN_RS03555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SMN_RS03565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMN_RS03585	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMN_RS03585	COG1776	CheC inhibitor of MCP methylation
SMN_RS03600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMN_RS03610	COG0748	coenzyme F420 binding
SMN_RS03645	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMN_RS03655	COG1113	amino acid transport
SMN_RS03660	COG0730	response to heat
SMN_RS03665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMN_RS03670	COG1301	dicarboxylic acid transport
SMN_RS03685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMN_RS03685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMN_RS03690	COG1971	Probably functions as a manganese efflux pump
SMN_RS03700	COG0484	heat shock protein binding
SMN_RS03725	COG1271	oxidase subunit
SMN_RS03730	COG1294	oxidase, subunit
SMN_RS03735	COG0745	RESPONSE REGULATOR receiver
SMN_RS03740	COG0642	Histidine kinase
SMN_RS03745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMN_RS03755	COG0840	transmembrane signaling receptor activity
SMN_RS03760	COG0318	PFAM AMP-dependent synthetase and ligase
SMN_RS03765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMN_RS03770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMN_RS03785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMN_RS03790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMN_RS03815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMN_RS03850	COG0784	Response regulator, receiver
SMN_RS03850	COG5002	protein histidine kinase activity
SMN_RS03850	COG2205	protein histidine kinase activity
SMN_RS03865	COG0322	excinuclease ABC activity
SMN_RS03875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SMN_RS03880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SMN_RS03885	COG0519	Catalyzes the synthesis of GMP from XMP
SMN_RS03885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMN_RS03915	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMN_RS03935	COG0745	RESPONSE REGULATOR receiver
SMN_RS03960	COG0511	ligase activity, forming carbon-carbon bonds
SMN_RS03970	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMN_RS03975	COG0165	Argininosuccinate lyase
SMN_RS03980	COG0537	adenosine 5'-monophosphoramidase activity
SMN_RS03985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMN_RS03990	COG0072	phenylalanine-tRNA ligase activity
SMN_RS03990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMN_RS03995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMN_RS04000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMN_RS04005	COG1185	polyribonucleotide nucleotidyltransferase activity
SMN_RS04005	COG0539	negative regulation of cytoplasmic translation
SMN_RS04015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMN_RS04025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMN_RS04035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMN_RS04045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMN_RS04050	COG0840	transmembrane signaling receptor activity
SMN_RS04060	COG0840	transmembrane signaling receptor activity
SMN_RS04080	COG2081	HI0933 family
SMN_RS04100	COG1981	membrane
SMN_RS04125	COG2200	EAL domain
SMN_RS04125	COG2199	diguanylate cyclase activity
SMN_RS04125	COG3287	FIST C domain
SMN_RS04130	COG1902	pentaerythritol trinitrate reductase activity
SMN_RS04150	COG0840	transmembrane signaling receptor activity
SMN_RS04170	COG0587	DNA-directed DNA polymerase activity
SMN_RS04175	COG0517	IMP dehydrogenase activity
SMN_RS04190	COG0642	Histidine kinase
SMN_RS04200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMN_RS04205	COG0569	domain protein
SMN_RS04220	COG0772	Belongs to the SEDS family
SMN_RS04225	COG0564	pseudouridine synthase activity
SMN_RS04235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMN_RS04240	COG1136	(ABC) transporter
SMN_RS04255	COG0528	UMP kinase activity
SMN_RS04260	COG1758	RNA polymerase activity
SMN_RS04270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMN_RS04280	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMN_RS04290	COG0563	adenylate kinase activity
SMN_RS04295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMN_RS04310	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMN_RS04315	COG0497	DNA recombination
SMN_RS04320	COG1620	l-lactate permease
SMN_RS04325	COG3706	GGDEF domain
SMN_RS04330	COG0084	hydrolase, TatD family'
SMN_RS04335	COG3942	CHAP domain
SMN_RS04335	COG1388	LysM domain
SMN_RS04340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMN_RS04345	COG0131	Imidazoleglycerol-phosphate dehydratase
SMN_RS04350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SMN_RS04365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMN_RS04380	COG0768	penicillin binding
SMN_RS04400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMN_RS04400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMN_RS04410	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SMN_RS04435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMN_RS04440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMN_RS04450	COG3005	denitrification pathway
SMN_RS04460	COG1333	cytochrome c biogenesis protein
SMN_RS04460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMN_RS04480	COG3545	Serine hydrolase
SMN_RS04490	COG1346	cytolysis
SMN_RS04505	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
SMN_RS04515	COG0398	Pfam SNARE associated Golgi protein
SMN_RS04525	COG0398	Pfam SNARE associated Golgi protein
SMN_RS04530	COG2226	methyltransferase
SMN_RS04535	COG0697	spore germination
SMN_RS04570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMN_RS04575	COG4716	Myosin-crossreactive antigen
SMN_RS04585	COG4585	Histidine kinase
SMN_RS04600	COG0109	protoheme IX farnesyltransferase activity
SMN_RS04605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMN_RS04620	COG1845	cytochrome c oxidase, subunit III
SMN_RS04620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMN_RS04660	COG4804	nuclease activity
SMN_RS04675	COG0243	molybdopterin cofactor binding
SMN_RS04680	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS04685	COG0348	domain, Protein
SMN_RS04690	COG3043	anaerobic respiration
SMN_RS04695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_RS04695	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_RS04740	COG1595	DNA-templated transcription, initiation
SMN_RS04755	COG0243	molybdopterin cofactor binding
SMN_RS04770	COG0745	RESPONSE REGULATOR receiver
SMN_RS04780	COG3852	Histidine kinase
SMN_RS04785	COG2863	cytochrome
SMN_RS04790	COG0723	plastoquinol--plastocyanin reductase activity
SMN_RS04795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMN_RS04815	COG2200	EAL domain
SMN_RS04815	COG3287	FIST C domain
SMN_RS04815	COG2199	diguanylate cyclase activity
SMN_RS04820	COG0688	phosphatidylethanolamine metabolic process
SMN_RS04825	COG0513	Belongs to the DEAD box helicase family
SMN_RS04840	COG2964	Protein conserved in bacteria
SMN_RS04845	COG2084	Dehydrogenase
SMN_RS04855	COG3383	formate dehydrogenase (NAD+) activity
SMN_RS04860	COG3383	formate dehydrogenase (NAD+) activity
SMN_RS04865	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS04875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMN_RS04880	COG2258	MOSC domain
SMN_RS04885	COG1280	lysine exporter protein (LysE YggA)
SMN_RS04890	COG0784	Response regulator, receiver
SMN_RS04890	COG3437	response regulator, receiver
SMN_RS04905	COG0217	transcriptional regulatory protein
SMN_RS04915	COG2358	TRAP transporter, solute receptor (TAXI family
SMN_RS04930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMN_RS04990	COG1696	Membrane protein involved in D-alanine export
SMN_RS05040	COG1305	Transglutaminase-like
SMN_RS05060	COG1305	Transglutaminase-like
SMN_RS05070	COG2308	Evidence 4 Homologs of previously reported genes of
SMN_RS05080	COG2966	Psort location CytoplasmicMembrane, score
SMN_RS05085	COG3610	response to peptide
SMN_RS05090	COG2703	oxygen carrier activity
SMN_RS05095	COG2217	Heavy metal translocating P-type atpase
SMN_RS05100	COG0640	Transcriptional regulator
SMN_RS05105	COG1280	lysine exporter protein (LysE YggA)
SMN_RS05115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMN_RS05120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMN_RS05120	COG2169	Transcriptional regulator
SMN_RS05130	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMN_RS05140	COG3290	protein histidine kinase activity
SMN_RS05140	COG0840	transmembrane signaling receptor activity
SMN_RS05150	COG0352	thiamine-phosphate diphosphorylase activity
SMN_RS05165	COG1272	protein, Hemolysin III
SMN_RS05180	COG0247	lactate metabolic process
SMN_RS05190	COG1556	Lactate utilization protein
SMN_RS05195	COG0697	spore germination
SMN_RS05215	COG2176	DNA-directed DNA polymerase activity
SMN_RS05240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMN_RS05250	COG0501	Belongs to the peptidase M48B family
SMN_RS05270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMN_RS05275	COG2201	protein-glutamate methylesterase activity
SMN_RS05280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMN_RS05285	COG0586	Pfam SNARE associated Golgi protein
SMN_RS05290	COG0133	tryptophan synthase activity
SMN_RS05295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMN_RS05305	COG0698	ribose 5-phosphate isomerase
SMN_RS05310	COG1994	Peptidase M50
SMN_RS05315	COG0681	Belongs to the peptidase S26 family
SMN_RS05320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMN_RS05440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMN_RS05455	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMN_RS05460	COG0612	Peptidase, M16
SMN_RS05465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMN_RS05495	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SMN_RS05500	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMN_RS05505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMN_RS05510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMN_RS05515	COG0629	single-stranded DNA binding
SMN_RS05520	COG0360	Binds together with S18 to 16S ribosomal RNA
SMN_RS05525	COG1466	dna polymerase III delta subunit
SMN_RS05530	COG0557	exoribonuclease II activity
SMN_RS05540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMN_RS05545	COG2894	cell division
SMN_RS05550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SMN_RS05560	COG0758	DNA mediated transformation
SMN_RS05565	COG0730	response to heat
SMN_RS05570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMN_RS05585	COG1760	l-serine dehydratase
SMN_RS05590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMN_RS05595	COG2860	membrane
SMN_RS05600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMN_RS05615	COG0736	holo-[acyl-carrier-protein] synthase activity
SMN_RS05620	COG1580	Controls the rotational direction of flagella during chemotaxis
SMN_RS05625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SMN_RS05630	COG0552	protein localization to endoplasmic reticulum
SMN_RS05635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMN_RS05645	COG1418	mRNA catabolic process
SMN_RS05650	COG1132	(ABC) transporter
SMN_RS05660	COG0586	Pfam SNARE associated Golgi protein
SMN_RS05675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMN_RS05690	COG0745	RESPONSE REGULATOR receiver
SMN_RS05695	COG2204	response regulator
SMN_RS05700	COG5002	protein histidine kinase activity
SMN_RS05700	COG5001	Diguanylate cyclase
SMN_RS05720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMN_RS05760	COG1518	maintenance of DNA repeat elements
SMN_RS05875	COG3328	transposase activity
SMN_RS05895	COG1450	Type ii and iii secretion system protein
SMN_RS05930	COG5002	protein histidine kinase activity
SMN_RS05935	COG1408	metallophosphoesterase
SMN_RS05940	COG2353	YceI-like domain
SMN_RS05955	COG1136	(ABC) transporter
SMN_RS05970	COG4456	Virulence-associated protein
SMN_RS05995	COG3328	transposase activity
SMN_RS06025	COG0242	peptide deformylase activity
SMN_RS06030	COG0824	Thioesterase
SMN_RS06040	COG1573	uracil-dna glycosylase
SMN_RS06055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMN_RS06070	COG0745	RESPONSE REGULATOR receiver
SMN_RS06075	COG3287	FIST C domain
SMN_RS06075	COG2200	EAL domain
SMN_RS06075	COG2199	diguanylate cyclase activity
SMN_RS06085	COG0745	RESPONSE REGULATOR receiver
SMN_RS06090	COG0426	domain, Protein
SMN_RS06105	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMN_RS06110	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMN_RS06115	COG2040	homocysteine
SMN_RS06120	COG1012	belongs to the aldehyde dehydrogenase family
SMN_RS06125	COG3264	Mechanosensitive ion channel
SMN_RS06125	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SMN_RS06135	COG0784	Response regulator, receiver
SMN_RS06135	COG2205	protein histidine kinase activity
SMN_RS06140	COG3437	response regulator, receiver
SMN_RS06150	COG1433	Dinitrogenase iron-molybdenum cofactor
SMN_RS06180	COG0633	Ferredoxin
SMN_RS06185	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMN_RS06220	COG2026	Addiction module toxin, RelE StbE family
SMN_RS06225	COG3645	SOS response
SMN_RS06280	COG1451	nucleotide metabolic process
SMN_RS06330	COG0697	spore germination
SMN_RS06340	COG3706	GGDEF domain
SMN_RS06345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMN_RS06385	COG0243	molybdopterin cofactor binding
SMN_RS06400	COG0747	negative chemotaxis
SMN_RS06405	COG0745	RESPONSE REGULATOR receiver
SMN_RS06420	COG1276	copper resistance
SMN_RS06425	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SMN_RS06435	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMN_RS06440	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMN_RS06455	COG0745	RESPONSE REGULATOR receiver
SMN_RS06465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMN_RS06465	COG3153	acetyltransferase
SMN_RS06520	COG0493	'glutamate synthase
SMN_RS06525	COG0375	protein maturation
SMN_RS06530	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_RS06540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS06550	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMN_RS06565	COG2814	Major facilitator Superfamily
SMN_RS06595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMN_RS06605	COG1131	(ABC) transporter
SMN_RS06610	COG0842	Transport permease protein
SMN_RS06615	COG4456	Virulence-associated protein
SMN_RS06640	COG0667	Aldo Keto reductase
SMN_RS06645	COG1053	succinate dehydrogenase
SMN_RS06680	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SMN_RS06685	COG0585	pseudouridine synthase activity
SMN_RS06695	COG0569	domain protein
SMN_RS06695	COG0475	glutathione-regulated potassium exporter activity
SMN_RS06715	COG2203	Gaf domain
SMN_RS06715	COG2199	diguanylate cyclase activity
SMN_RS06720	COG0351	phosphomethylpyrimidine kinase
SMN_RS06720	COG0352	thiamine-phosphate diphosphorylase activity
SMN_RS06730	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SMN_RS06740	COG0428	transporter
SMN_RS06750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMN_RS06760	COG0840	transmembrane signaling receptor activity
SMN_RS06765	COG1234	tRNA 3'-trailer cleavage
SMN_RS06775	COG0488	(ABC) transporter
SMN_RS06785	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SMN_RS06790	COG1309	transcriptional regulator
SMN_RS06820	COG0778	Nitroreductase
SMN_RS06825	COG0778	Nitroreductase
SMN_RS06830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMN_RS06840	COG0415	Belongs to the DNA photolyase family
SMN_RS06850	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMN_RS06875	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SMN_RS06890	COG4145	pantothenate transmembrane transporter activity
SMN_RS06905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SMN_RS06920	COG0742	ribosomal rna small subunit methyltransferase
SMN_RS06925	COG1706	bacterial-type flagellum-dependent cell motility
SMN_RS06930	COG3951	Flagellar rod assembly protein muramidase FlgJ
SMN_RS06950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMN_RS06960	COG0659	secondary active sulfate transmembrane transporter activity
SMN_RS06965	COG1942	4-Oxalocrotonate Tautomerase
SMN_RS06970	COG0356	it plays a direct role in the translocation of protons across the membrane
SMN_RS06990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMN_RS07000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMN_RS07005	COG0101	tRNA pseudouridine synthase activity
SMN_RS07015	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SMN_RS07025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMN_RS07030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMN_RS07035	COG1338	Plays a role in the flagellum-specific transport system
SMN_RS07040	COG0676	glucose-6-phosphate 1-epimerase activity
SMN_RS07045	COG1733	regulation of RNA biosynthetic process
SMN_RS07050	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMN_RS07060	COG4269	membrane
SMN_RS07075	COG3174	membrane
SMN_RS07080	COG1032	radical SAM domain protein
SMN_RS07085	COG0166	Belongs to the GPI family
SMN_RS07110	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SMN_RS07120	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
SMN_RS07125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SMN_RS07130	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMN_RS07135	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMN_RS07165	COG0298	carbon dioxide binding
SMN_RS07170	COG0409	Hydrogenase expression formation protein
SMN_RS07175	COG0309	Hydrogenase expression formation protein (HypE)
SMN_RS07185	COG1247	-acetyltransferase
SMN_RS07190	COG0546	phosphoglycolate phosphatase activity
SMN_RS07210	COG0039	L-malate dehydrogenase activity
SMN_RS07220	COG2205	protein histidine kinase activity
SMN_RS07220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMN_RS07230	COG0471	metal ion transport
SMN_RS07235	COG0247	lactate metabolic process
SMN_RS07240	COG0277	FAD linked oxidase domain protein
SMN_RS07245	COG0045	succinate-CoA ligase (ADP-forming) activity
SMN_RS07250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SMN_RS07260	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMN_RS07260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMN_RS07265	COG3962	Belongs to the TPP enzyme family
SMN_RS07290	COG0114	fumarate hydratase activity
SMN_RS07305	COG2095	MarC family integral membrane protein
SMN_RS07325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMN_RS07330	COG0750	zinc metalloprotease
SMN_RS07335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMN_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
SMN_RS07345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMN_RS07355	COG0167	dihydroorotate dehydrogenase activity
SMN_RS07360	COG1132	(ABC) transporter
SMN_RS07365	COG0215	cysteine-tRNA ligase activity
SMN_RS07370	COG0728	peptidoglycan biosynthetic process
SMN_RS07380	COG0632	four-way junction helicase activity
SMN_RS07385	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMN_RS07405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMN_RS07410	COG0857	belongs to the CobB CobQ family
SMN_RS07410	COG0280	phosphate acetyltransferase
SMN_RS07415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMN_RS07440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMN_RS07480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SMN_RS07485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SMN_RS07500	COG0137	argininosuccinate synthase activity
SMN_RS07505	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMN_RS07510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMN_RS07515	COG0802	atpase or kinase
SMN_RS07520	COG1137	ATPase activity
SMN_RS07525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMN_RS07545	COG0419	ATPase involved in DNA repair
SMN_RS07550	COG1196	nuclear chromosome segregation
SMN_RS07620	COG1053	succinate dehydrogenase
SMN_RS07695	COG3279	Response regulator of the LytR AlgR family
SMN_RS07705	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS07715	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SMN_RS07725	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SMN_RS07735	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMN_RS07745	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SMN_RS07760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMN_RS07765	COG1120	ATPase activity
SMN_RS07780	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SMN_RS07825	COG1132	(ABC) transporter
SMN_RS07830	COG1797	cobyrinic acid a,c-diamide synthase activity
SMN_RS07840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMN_RS07840	COG1648	precorrin-2 dehydrogenase activity
SMN_RS07845	COG1309	transcriptional regulator
SMN_RS07965	COG0582	viral genome integration into host DNA
SMN_RS07975	COG0776	regulation of translation
SMN_RS07980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMN_RS07985	COG1674	ftsk spoiiie
SMN_RS07985	COG1196	nuclear chromosome segregation
SMN_RS07990	COG1049	propionate catabolic process, 2-methylcitrate cycle
SMN_RS07995	COG1047	Peptidyl-prolyl cis-trans
SMN_RS08000	COG0574	Belongs to the PEP-utilizing enzyme family
SMN_RS08000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMN_RS08005	COG2814	Major facilitator Superfamily
SMN_RS08025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMN_RS08035	COG1832	CoA-binding protein
SMN_RS08040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMN_RS08050	COG1126	abc transporter atp-binding protein
SMN_RS08055	COG0765	amino acid transport
SMN_RS08060	COG4597	amino acid ABC transporter
SMN_RS08065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMN_RS08070	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMN_RS08085	COG0586	Pfam SNARE associated Golgi protein
SMN_RS08100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMN_RS08115	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMN_RS08120	COG0727	PFAM Uncharacterised protein family (UPF0153)
SMN_RS08130	COG0134	indole-3-glycerol-phosphate synthase activity
SMN_RS08140	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SMN_RS08150	COG0310	cobalt ion transport
SMN_RS08170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMN_RS08175	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SMN_RS08190	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMN_RS08200	COG0248	Ppx GppA phosphatase
SMN_RS08205	COG0028	Belongs to the TPP enzyme family
SMN_RS08215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMN_RS08225	COG0493	'glutamate synthase
SMN_RS08230	COG0436	Aminotransferase
SMN_RS08235	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMN_RS08265	COG1045	serine acetyltransferase
SMN_RS08270	COG1166	arginine decarboxylase activity
SMN_RS08275	COG0124	histidyl-tRNA synthetase
SMN_RS08285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMN_RS08290	COG0163	prenyltransferase activity
SMN_RS08305	COG0840	transmembrane signaling receptor activity
SMN_RS08310	COG0303	'Molybdopterin
SMN_RS08315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMN_RS08345	COG0489	protein tyrosine kinase activity
SMN_RS08355	COG1342	Belongs to the UPF0251 family
SMN_RS08360	COG1691	(AIR) carboxylase
SMN_RS08365	COG1606	tRNA processing
SMN_RS08370	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SMN_RS08375	COG3875	lactate racemase activity
SMN_RS08380	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SMN_RS08380	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SMN_RS08390	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SMN_RS08425	COG0582	viral genome integration into host DNA
SMN_RS08430	COG0343	queuine tRNA-ribosyltransferase activity
SMN_RS08440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMN_RS08450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMN_RS08455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMN_RS08475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMN_RS08490	COG2378	regulation of single-species biofilm formation
SMN_RS08495	COG1187	pseudouridine synthase activity
SMN_RS08500	COG0028	Belongs to the TPP enzyme family
SMN_RS08510	COG2066	Belongs to the glutaminase family
SMN_RS08525	COG1981	membrane
SMN_RS08530	COG1309	transcriptional regulator
SMN_RS08560	COG0840	transmembrane signaling receptor activity
SMN_RS08670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMN_RS08690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMN_RS08805	COG3328	transposase activity
SMN_RS08860	COG0582	viral genome integration into host DNA
SMN_RS08880	COG0776	regulation of translation
SMN_RS09080	COG3344	reverse transcriptase
SMN_RS09150	COG0629	single-stranded DNA binding
SMN_RS09355	COG4774	siderophore transport
SMN_RS09465	COG0582	viral genome integration into host DNA
SMN_RS09470	COG1592	Rubrerythrin
SMN_RS09480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMN_RS09485	COG0181	hydroxymethylbilane synthase activity
SMN_RS09500	COG0442	prolyl-tRNA aminoacylation
SMN_RS09505	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMN_RS09510	COG0142	geranyltranstransferase activity
SMN_RS09530	COG1959	2 iron, 2 sulfur cluster binding
SMN_RS09540	COG3706	GGDEF domain
SMN_RS09545	COG0525	valine-tRNA ligase activity
SMN_RS09550	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SMN_RS09555	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMN_RS09565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMN_RS09580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMN_RS09585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMN_RS09595	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMN_RS09605	COG0500	methyltransferase
SMN_RS09620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMN_RS09625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMN_RS09630	COG1663	tetraacyldisaccharide 4'-kinase activity
SMN_RS09635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMN_RS09640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMN_RS09645	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SMN_RS09660	COG4232	protein-disulfide reductase activity
SMN_RS09670	COG0443	Heat shock 70 kDa protein
SMN_RS09675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMN_RS09680	COG1420	regulation of RNA biosynthetic process
SMN_RS09695	COG1959	2 iron, 2 sulfur cluster binding
SMN_RS09700	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMN_RS09705	COG2404	hydrolase activity, acting on ester bonds
SMN_RS09715	COG2226	methyltransferase
SMN_RS09725	COG0196	riboflavin kinase activity
SMN_RS09730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMN_RS09735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMN_RS09740	COG0730	response to heat
SMN_RS09750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMN_RS09765	COG0527	aspartate kinase activity
SMN_RS09770	COG0494	nUDIX hydrolase
SMN_RS09775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMN_RS09785	COG0789	Transcriptional regulator
SMN_RS09790	COG0484	heat shock protein binding
SMN_RS09795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMN_RS09800	COG0745	RESPONSE REGULATOR receiver
SMN_RS09805	COG0642	Histidine kinase
SMN_RS09820	COG0653	protein targeting
SMN_RS09835	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMN_RS09840	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMN_RS09850	COG0706	membrane insertase activity
SMN_RS09855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMN_RS09865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMN_RS09880	COG4865	methylaspartate mutase activity
SMN_RS10010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMN_RS10025	COG0542	response to heat
SMN_RS10030	COG0793	Belongs to the peptidase S41A family
SMN_RS10035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMN_RS10040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMN_RS10045	COG0047	phosphoribosylformylglycinamidine synthase activity
SMN_RS10055	COG0204	Acyl-transferase
SMN_RS10060	COG0326	Molecular chaperone. Has ATPase activity
SMN_RS10065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMN_RS10085	COG1331	Highly conserved protein containing a thioredoxin domain
SMN_RS10090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMN_RS10130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMN_RS10155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMN_RS10165	COG2608	mercury ion transmembrane transporter activity
SMN_RS10170	COG2217	Heavy metal translocating P-type atpase
SMN_RS10175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMN_RS10190	COG0275	rRNA processing
SMN_RS10200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMN_RS10205	COG0849	cell division
SMN_RS10210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMN_RS10220	COG2890	protein-(glutamine-N5) methyltransferase activity
SMN_RS10225	COG0501	Belongs to the peptidase M48B family
SMN_RS10235	COG0488	(ABC) transporter
SMN_RS10240	COG0840	transmembrane signaling receptor activity
SMN_RS10250	COG2151	metal-sulfur cluster biosynthetic enzyme
SMN_RS10265	COG0138	bifunctional purine biosynthesis protein purh
SMN_RS10270	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SMN_RS10280	COG1607	acyl-coa hydrolase
SMN_RS10285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SMN_RS10290	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMN_RS10310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMN_RS10320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMN_RS10325	COG0805	protein transport
SMN_RS10330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMN_RS10355	COG3328	transposase activity
SMN_RS10370	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SMN_RS10375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMN_RS10380	COG0765	amino acid transport
SMN_RS10395	COG3437	response regulator, receiver
SMN_RS10405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMN_RS10410	COG1022	Amp-dependent synthetase and ligase
SMN_RS10420	COG4206	TonB-dependent receptor
SMN_RS10425	COG2205	protein histidine kinase activity
SMN_RS10430	COG0745	RESPONSE REGULATOR receiver
SMN_RS10435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMN_RS10440	COG0569	domain protein
SMN_RS10445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMN_RS10460	COG2068	MobA-Related Protein
SMN_RS10465	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMN_RS10465	COG3608	succinylglutamate desuccinylase aspartoacylase
SMN_RS10470	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SMN_RS10475	COG0535	radical SAM domain protein
SMN_RS10505	COG2205	protein histidine kinase activity
SMN_RS10510	COG0745	RESPONSE REGULATOR receiver
SMN_RS10520	COG3038	cytochrome b561
SMN_RS10530	COG0642	Histidine kinase
SMN_RS10535	COG0745	RESPONSE REGULATOR receiver
SMN_RS10545	COG1230	cation diffusion facilitator family transporter
SMN_RS10565	COG4774	siderophore transport
SMN_RS10575	COG0668	transmembrane transport
SMN_RS10615	COG4263	nitrous-oxide reductase activity
SMN_RS10630	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SMN_RS10640	COG1410	methionine synthase
SMN_RS10640	COG0646	methionine synthase
SMN_RS10655	COG0840	transmembrane signaling receptor activity
SMN_RS10660	COG1280	lysine exporter protein (LysE YggA)
SMN_RS10675	COG0004	ammonium transporteR
SMN_RS10680	COG0347	Belongs to the P(II) protein family
SMN_RS10690	COG1401	restriction endodeoxyribonuclease activity
SMN_RS10725	COG0288	reversible hydration of carbon dioxide
SMN_RS10730	COG3123	guanosine phosphorylase activity
SMN_RS10740	COG2081	HI0933 family
SMN_RS10750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SMN_RS10755	COG0788	formyltetrahydrofolate deformylase activity
SMN_RS10775	COG0473	3-isopropylmalate dehydrogenase activity
SMN_RS10780	COG0066	3-isopropylmalate dehydratase activity
SMN_RS10785	COG1119	ATPase activity
SMN_RS10805	COG0708	Exodeoxyribonuclease III
SMN_RS10820	COG0840	transmembrane signaling receptor activity
SMN_RS10830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMN_RS10835	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SMN_RS10840	COG3005	denitrification pathway
SMN_RS10845	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SMN_RS10850	COG0840	transmembrane signaling receptor activity
SMN_RS10860	COG0745	RESPONSE REGULATOR receiver
SMN_RS10880	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SMN_RS10890	COG3706	GGDEF domain
SMN_RS10900	COG4895	conserved protein (DUF2196)
SMN_RS10920	COG0513	Belongs to the DEAD box helicase family
SMN_RS10930	COG5001	Diguanylate cyclase
SMN_RS10935	COG0642	Histidine kinase
SMN_RS10940	COG0745	RESPONSE REGULATOR receiver
SMN_RS10975	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMN_RS10980	COG0372	Belongs to the citrate synthase family
SMN_RS10985	COG2079	MmgE PrpD family protein
SMN_RS10995	COG2824	Alkylphosphonate utilization operon protein PhnA
SMN_RS11005	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SMN_RS11010	COG4786	Flagellar basal body rod
SMN_RS11015	COG4786	Flagellar basal body rod
SMN_RS11020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMN_RS11030	COG1733	regulation of RNA biosynthetic process
SMN_RS11045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMN_RS11050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMN_RS11055	COG3162	membrane
SMN_RS11060	COG0745	RESPONSE REGULATOR receiver
SMN_RS11070	COG2957	Belongs to the agmatine deiminase family
SMN_RS11080	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMN_RS11085	COG1918	ferrous iron import across plasma membrane
SMN_RS11110	COG3585	molybdate ion transport
SMN_RS11120	COG0598	Magnesium transport protein CorA
SMN_RS11125	COG0739	heme binding
SMN_RS11135	COG0277	FAD linked oxidase domain protein
SMN_RS11140	COG1295	ribonuclease BN
SMN_RS11150	COG0305	Participates in initiation and elongation during chromosome replication
SMN_RS11150	COG0305	Participates in initiation and elongation during chromosome replication
SMN_RS11155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMN_RS11160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMN_RS11165	COG2165	general secretion pathway protein
SMN_RS11185	COG0556	nucleotide-excision repair
SMN_RS11195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SMN_RS11200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMN_RS11205	COG2176	DNA-directed DNA polymerase activity
SMN_RS11210	COG0135	phosphoribosylanthranilate isomerase activity
SMN_RS11215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SMN_RS11225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMN_RS11240	COG1692	metallophosphoesterase
SMN_RS11245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMN_RS11255	COG0739	heme binding
SMN_RS11260	COG0285	dihydrofolate synthase activity
SMN_RS11275	COG0495	leucyl-tRNA aminoacylation
SMN_RS11280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMN_RS11285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMN_RS11290	COG1862	Preprotein translocase
SMN_RS11295	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SMN_RS11300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMN_RS11310	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SMN_RS11315	COG0542	response to heat
SMN_RS11320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMN_RS11330	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMN_RS11335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMN_RS11340	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SMN_RS11345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMN_RS11350	COG0210	DNA helicase
SMN_RS11380	COG0540	Belongs to the ATCase OTCase family
SMN_RS11390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMN_RS11435	COG0228	four-way junction DNA binding
SMN_RS11440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMN_RS11445	COG0564	pseudouridine synthase activity
SMN_RS11450	COG1519	Transferase
SMN_RS11460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SMN_RS11475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMN_RS11480	COG0826	peptidase U32
SMN_RS11490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMN_RS11495	COG0174	glutamine synthetase
SMN_RS11505	COG0444	Belongs to the ABC transporter superfamily
SMN_RS11510	COG0156	8-amino-7-oxononanoate synthase activity
SMN_RS11515	COG0424	maF-like protein
SMN_RS11525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMN_RS11540	COG5002	protein histidine kinase activity
SMN_RS11545	COG0243	molybdopterin cofactor binding
SMN_RS11550	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS11555	COG3302	dmso reductase anchor subunit
SMN_RS11560	COG3381	protein complex oligomerization
SMN_RS11575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMN_RS11590	COG1558	bacterial-type flagellum-dependent cell motility
SMN_RS11595	COG1815	bacterial-type flagellum-dependent cell motility
SMN_RS11600	COG0772	Belongs to the SEDS family
SMN_RS11605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMN_RS11620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMN_RS11670	COG0512	Glutamine amidotransferase of anthranilate synthase
SMN_RS11675	COG2814	Major facilitator Superfamily
SMN_RS11685	COG0640	Transcriptional regulator
SMN_RS11715	COG2301	Belongs to the HpcH HpaI aldolase family
SMN_RS11725	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SMN_RS11730	COG3180	Ammonia monooxygenase
SMN_RS11740	COG3290	protein histidine kinase activity
SMN_RS11745	COG4565	transcriptional regulatory protein
SMN_RS11765	COG0784	Response regulator, receiver
SMN_RS11765	COG5002	protein histidine kinase activity
SMN_RS11765	COG2205	protein histidine kinase activity
SMN_RS11770	COG3437	response regulator, receiver
SMN_RS11775	COG2814	Major facilitator Superfamily
SMN_RS11785	COG2252	PERMEase
SMN_RS11790	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMN_RS11805	COG0133	tryptophan synthase activity
SMN_RS11820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMN_RS11825	COG3706	GGDEF domain
SMN_RS11855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMN_RS11880	COG0488	(ABC) transporter
SMN_RS11890	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_RS11895	COG0651	ATP synthesis coupled electron transport
SMN_RS11900	COG0650	Formate hydrogenlyase subunit 4
SMN_RS11905	COG4237	Hydrogenase 4 membrane
SMN_RS11910	COG0651	ATP synthesis coupled electron transport
SMN_RS11915	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SMN_RS11915	COG3261	NADH dehydrogenase
SMN_RS11925	COG3260	NADH ubiquinone oxidoreductase 20
SMN_RS11950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMN_RS11960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMN_RS11980	COG2171	N-acyltransferase activity
SMN_RS11985	COG0489	protein tyrosine kinase activity
SMN_RS11990	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMN_RS11990	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMN_RS12000	COG2046	Belongs to the sulfate adenylyltransferase family
SMN_RS12015	COG2353	YceI-like domain
SMN_RS12020	COG1739	Uncharacterized protein family UPF0029
SMN_RS12025	COG0157	Belongs to the NadC ModD family
SMN_RS12030	COG4208	sulfate ABC transporter
SMN_RS12040	COG3842	ATPase activity
SMN_RS12065	COG1686	Belongs to the peptidase S11 family
SMN_RS12070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMN_RS12075	COG0577	efflux transmembrane transporter activity
SMN_RS12075	COG1136	(ABC) transporter
SMN_RS12080	COG0577	efflux transmembrane transporter activity
SMN_RS12080	COG1136	(ABC) transporter
SMN_RS12085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMN_RS12105	COG0668	transmembrane transport
SMN_RS12175	COG0284	orotidine-5'-phosphate decarboxylase activity
SMN_RS12180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMN_RS12185	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMN_RS12200	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SMN_RS12205	COG0697	spore germination
SMN_RS12210	COG0668	transmembrane transport
SMN_RS12215	COG1160	GTP binding
SMN_RS12230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMN_RS12240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMN_RS12245	COG1183	phosphatidylcholine synthase activity
SMN_RS12255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMN_RS12260	COG2264	protein methyltransferase activity
SMN_RS12265	COG0745	RESPONSE REGULATOR receiver
SMN_RS12270	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMN_RS12275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMN_RS12290	COG1086	Polysaccharide biosynthesis protein
SMN_RS12295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMN_RS12310	COG0438	transferase activity, transferring glycosyl groups
SMN_RS12315	COG0110	maltose O-acetyltransferase activity
SMN_RS12330	COG0110	maltose O-acetyltransferase activity
SMN_RS12350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMN_RS12360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMN_RS12365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMN_RS12375	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SMN_RS12390	COG1793	dna ligase
SMN_RS12400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMN_RS12405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMN_RS12450	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SMN_RS12455	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SMN_RS12455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SMN_RS12460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMN_RS12480	COG2217	Heavy metal translocating P-type atpase
SMN_RS12480	COG2608	mercury ion transmembrane transporter activity
SMN_RS12485	COG5001	Diguanylate cyclase
SMN_RS12485	COG5002	protein histidine kinase activity
SMN_RS12490	COG0697	spore germination
SMN_RS12500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMN_RS12510	COG1496	oxidoreductase activity
SMN_RS12525	COG1984	allophanate hydrolase subunit 2
SMN_RS12535	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SMN_RS12555	COG2201	protein-glutamate methylesterase activity
SMN_RS12565	COG0445	tRNA wobble uridine modification
SMN_RS12570	COG0723	plastoquinol--plastocyanin reductase activity
SMN_RS12590	COG0825	malonyl-CoA metabolic process
SMN_RS12595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMN_RS12600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMN_RS12610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SMN_RS12615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMN_RS12620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMN_RS12630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SMN_RS12650	COG0300	oxidoreductase activity
SMN_RS12655	COG0277	FAD linked oxidase domain protein
SMN_RS12665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMN_RS12670	COG2801	Transposase and inactivated derivatives
SMN_RS12760	COG1134	teichoic acid transport
SMN_RS12780	COG1682	transport, permease protein
SMN_RS12785	COG1088	dTDP-glucose 4,6-dehydratase activity
SMN_RS12800	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMN_RS12805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMN_RS12830	COG0745	RESPONSE REGULATOR receiver
SMN_RS12835	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SMN_RS12850	COG0390	transport system, permease component
SMN_RS12855	COG0439	Biotin carboxylase
SMN_RS12870	COG0306	phosphate transporter
SMN_RS12875	COG0513	Belongs to the DEAD box helicase family
SMN_RS12880	COG1671	Belongs to the UPF0178 family
SMN_RS12890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMN_RS12900	COG0573	inorganic phosphate transmembrane transporter activity
SMN_RS12905	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMN_RS12910	COG0840	transmembrane signaling receptor activity
SMN_RS12910	COG3290	protein histidine kinase activity
SMN_RS12915	COG3384	dioxygenase
SMN_RS12920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMN_RS12925	COG0471	metal ion transport
SMN_RS12930	COG0840	transmembrane signaling receptor activity
SMN_RS12955	COG0745	RESPONSE REGULATOR receiver
SMN_RS12965	COG1607	acyl-coa hydrolase
SMN_RS12995	COG1733	regulation of RNA biosynthetic process
SMN_RS13000	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMN_RS13010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMN_RS13015	COG0602	queuosine metabolic process
SMN_RS13040	COG1702	phosphate starvation-inducible protein PhoH
SMN_RS13050	COG2814	Major facilitator Superfamily
SMN_RS13055	COG0477	Major facilitator Superfamily
SMN_RS13065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMN_RS13085	COG3787	Belongs to the UPF0306 family
SMN_RS13090	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SMN_RS13120	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMN_RS13120	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMN_RS13120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMN_RS13120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMN_RS13125	COG0546	phosphoglycolate phosphatase activity
SMN_RS13150	COG2818	Glycosylase
SMN_RS13160	COG1979	alcohol dehydrogenase
SMN_RS13170	COG0038	chloride channel
SMN_RS13175	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMN_RS13190	COG4680	protein conserved in bacteria
SMN_RS13195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMN_RS13200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMN_RS13245	COG3278	Belongs to the heme-copper respiratory oxidase family
SMN_RS13250	COG0745	RESPONSE REGULATOR receiver
SMN_RS13265	COG0505	Belongs to the CarA family
SMN_RS13285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMN_RS13290	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMN_RS13295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMN_RS13305	COG0546	phosphoglycolate phosphatase activity
SMN_RS13310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMN_RS13325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMN_RS13330	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SMN_RS13335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMN_RS13350	COG0203	ribosomal protein L17
SMN_RS13360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMN_RS13365	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMN_RS13370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMN_RS13375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMN_RS13385	COG0024	Methionine aminopeptidase
SMN_RS13390	COG0201	protein transport
SMN_RS13395	COG0200	Binds to the 23S rRNA
SMN_RS13400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMN_RS13405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMN_RS13410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMN_RS13415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMN_RS13430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMN_RS13435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMN_RS13440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMN_RS13445	COG0255	Belongs to the universal ribosomal protein uL29 family
SMN_RS13450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMN_RS13455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMN_RS13465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMN_RS13470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMN_RS13475	COG0089	rRNA binding
SMN_RS13480	COG0088	Forms part of the polypeptide exit tunnel
SMN_RS13485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMN_RS13490	COG0051	transcription antitermination factor activity, RNA binding
SMN_RS13505	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMN_RS13510	COG0672	)-iron permease
SMN_RS13535	COG0577	efflux transmembrane transporter activity
SMN_RS13535	COG1136	(ABC) transporter
SMN_RS13560	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMN_RS13565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMN_RS13570	COG0571	ribonuclease III activity
SMN_RS13575	COG0328	RNA-DNA hybrid ribonuclease activity
SMN_RS13585	COG0358	DNA primase activity
SMN_RS13590	COG0137	argininosuccinate synthase activity
SMN_RS13595	COG2201	protein-glutamate methylesterase activity
SMN_RS13615	COG0840	transmembrane signaling receptor activity
SMN_RS13620	COG2201	protein-glutamate methylesterase activity
SMN_RS13625	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SMN_RS13635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMN_RS13650	COG0840	transmembrane signaling receptor activity
SMN_RS13655	COG0835	chemotaxis
SMN_RS13660	COG0745	RESPONSE REGULATOR receiver
SMN_RS13665	COG0484	heat shock protein binding
SMN_RS13765	COG4206	TonB-dependent receptor
SMN_RS13785	COG1918	ferrous iron import across plasma membrane
SMN_RS13785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMN_RS13790	COG1918	ferrous iron import across plasma membrane
SMN_RS13800	COG4773	Receptor
SMN_RS13825	COG0848	biopolymer transport protein
SMN_RS13830	COG0811	peptide transport
SMN_RS13850	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SMN_RS13865	COG1011	Hydrolase
SMN_RS13870	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SMN_RS13875	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SMN_RS13895	COG1280	lysine exporter protein (LysE YggA)
SMN_RS13900	COG1090	epimerase
SMN_RS13950	COG2962	Rard protein
SMN_RS13960	COG0642	Histidine kinase
SMN_RS13965	COG2194	sulfuric ester hydrolase activity
SMN_RS13975	COG2200	EAL domain
SMN_RS13985	COG4191	Histidine kinase
SMN_RS13995	COG0840	transmembrane signaling receptor activity
SMN_RS14010	COG1342	Belongs to the UPF0251 family
SMN_RS14015	COG1968	undecaprenyl-diphosphatase activity
SMN_RS14020	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SMN_RS14045	COG1027	Aspartate ammonia-lyase
SMN_RS14050	COG1027	Aspartate ammonia-lyase
SMN_RS14055	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SMN_RS14060	COG0252	asparaginase activity
SMN_RS14065	COG3852	Histidine kinase
SMN_RS14070	COG0745	RESPONSE REGULATOR receiver
SMN_RS14085	COG3177	Filamentation induced by cAMP protein fic
SMN_RS14095	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMN_RS14120	COG1136	(ABC) transporter
SMN_RS14145	COG1333	cytochrome c biogenesis protein
SMN_RS14145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMN_RS14150	COG3301	Polysulphide reductase, NrfD
SMN_RS14155	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS14160	COG0545	Peptidyl-prolyl cis-trans isomerase
SMN_RS14165	COG0484	heat shock protein binding
SMN_RS14180	COG0840	transmembrane signaling receptor activity
SMN_RS14205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMN_RS14210	COG0586	Pfam SNARE associated Golgi protein
SMN_RS14230	COG0848	biopolymer transport protein
SMN_RS14235	COG0811	peptide transport
SMN_RS14240	COG0709	Synthesizes selenophosphate from selenide and ATP
SMN_RS14245	COG0425	Belongs to the sulfur carrier protein TusA family
SMN_RS14260	COG3447	MASE1 domain protein
SMN_RS14260	COG5002	protein histidine kinase activity
SMN_RS14260	COG5001	Diguanylate cyclase
SMN_RS14280	COG4662	Binding-protein-dependent transport system inner membrane component
SMN_RS14285	COG2998	abc-type tungstate transport system, permease component
SMN_RS14295	COG3842	ATPase activity
SMN_RS14300	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMN_RS14310	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SMN_RS14320	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS14345	COG1120	ATPase activity
SMN_RS14350	COG1120	ATPase activity
SMN_RS14355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMN_RS14360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMN_RS14375	COG0848	biopolymer transport protein
SMN_RS14380	COG0811	peptide transport
SMN_RS14410	COG0500	methyltransferase
SMN_RS14420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMN_RS14445	COG4977	sequence-specific DNA binding
SMN_RS14445	COG1917	Cupin 2, conserved barrel domain protein
SMN_RS14455	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS14485	COG4191	Histidine kinase
SMN_RS14490	COG0745	RESPONSE REGULATOR receiver
SMN_RS14495	COG1921	L-seryl-tRNASec selenium transferase activity
SMN_RS14520	COG1741	Belongs to the pirin family
SMN_RS14555	COG0745	RESPONSE REGULATOR receiver
SMN_RS14560	COG0642	Histidine kinase
SMN_RS14595	COG2986	histidine ammonia-lyase
SMN_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
SMN_RS14635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMN_RS14645	COG0513	Belongs to the DEAD box helicase family
SMN_RS14675	COG1305	Transglutaminase-like
SMN_RS14690	COG0745	RESPONSE REGULATOR receiver
SMN_RS14705	COG0439	Biotin carboxylase
SMN_RS14715	COG3665	Urea carboxylase-associated protein
SMN_RS14720	COG3842	ATPase activity
SMN_RS14725	COG2011	ABC-type metal ion transport system permease component
SMN_RS14735	COG0642	Histidine kinase
SMN_RS14740	COG0745	RESPONSE REGULATOR receiver
SMN_RS14750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMN_RS14755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMN_RS14765	COG1840	ABC-type Fe3 transport system, periplasmic component
SMN_RS14770	COG3842	ATPase activity
SMN_RS14780	COG0745	RESPONSE REGULATOR receiver
SMN_RS14785	COG2205	protein histidine kinase activity
SMN_RS14790	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SMN_RS14795	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMN_RS14800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMN_RS14805	COG0523	cobalamin synthesis protein
SMN_RS14830	COG0700	Nucleoside recognition
SMN_RS14835	COG3366	ferrous iron transmembrane transporter activity
SMN_RS14840	COG1473	amidohydrolase
SMN_RS14855	COG0300	oxidoreductase activity
SMN_RS14870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMN_RS14875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SMN_RS14880	COG2814	Major facilitator Superfamily
SMN_RS14885	COG1238	metal cluster binding
SMN_RS14905	COG0303	'Molybdopterin
SMN_RS14910	COG0314	molybdopterin synthase activity
SMN_RS14925	COG1104	cysteine desulfurase activity
SMN_RS14930	COG1157	protein secretion by the type III secretion system
SMN_RS14935	COG0302	gtp cyclohydrolase
SMN_RS14940	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMN_RS14945	COG0740	serine-type endopeptidase activity
SMN_RS14970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMN_RS14975	COG2022	thiamine diphosphate biosynthetic process
SMN_RS15050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SMN_RS15055	COG3976	FMN-binding domain protein
SMN_RS15055	COG0431	NADPH-dependent FMN reductase
SMN_RS15055	COG1053	succinate dehydrogenase
SMN_RS15060	COG0644	oxidoreductase
SMN_RS15120	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS15125	COG0243	molybdopterin cofactor binding
SMN_RS15145	COG0745	RESPONSE REGULATOR receiver
SMN_RS15150	COG0642	Histidine kinase
SMN_RS15155	COG1012	belongs to the aldehyde dehydrogenase family
SMN_RS15170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMN_RS15185	COG2183	response to ionizing radiation
SMN_RS15220	COG0840	transmembrane signaling receptor activity
SMN_RS15225	COG0778	Nitroreductase
SMN_RS15260	COG0577	efflux transmembrane transporter activity
SMN_RS15265	COG1136	(ABC) transporter
SMN_RS15290	COG1472	Belongs to the glycosyl hydrolase 3 family
SMN_RS15295	COG1301	dicarboxylic acid transport
SMN_RS15300	COG0475	glutathione-regulated potassium exporter activity
SMN_RS15305	COG1280	lysine exporter protein (LysE YggA)
SMN_RS15320	COG0454	-acetyltransferase
SMN_RS15325	COG0431	NADPH-dependent FMN reductase
SMN_RS15345	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMN_RS15350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMN_RS15370	COG0745	RESPONSE REGULATOR receiver
SMN_RS15375	COG0642	Histidine kinase
SMN_RS15380	COG3842	ATPase activity
SMN_RS15390	COG1840	ABC-type Fe3 transport system, periplasmic component
SMN_RS15405	COG0175	sulfate reduction
SMN_RS15410	COG0175	sulfate reduction
SMN_RS15415	COG2895	sulfate adenylyltransferase (ATP) activity
SMN_RS15425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMN_RS15435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMN_RS15445	COG2873	o-acetylhomoserine
SMN_RS15455	COG0482	sulfurtransferase activity
SMN_RS15480	COG5002	protein histidine kinase activity
SMN_RS15490	COG2203	Gaf domain
SMN_RS15490	COG2199	diguanylate cyclase activity
SMN_RS15505	COG0745	RESPONSE REGULATOR receiver
SMN_RS15545	COG4232	protein-disulfide reductase activity
SMN_RS15550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMN_RS15555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SMN_RS15560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMN_RS15570	COG0243	molybdopterin cofactor binding
SMN_RS15585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMN_RS15595	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SMN_RS15630	COG1136	(ABC) transporter
SMN_RS15630	COG0577	efflux transmembrane transporter activity
SMN_RS15685	COG1136	(ABC) transporter
SMN_RS15695	COG0745	RESPONSE REGULATOR receiver
SMN_RS15695	COG2205	protein histidine kinase activity
SMN_RS15695	COG4191	Histidine kinase
SMN_RS15710	COG0243	molybdopterin cofactor binding
SMN_RS15720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMN_RS15735	COG0861	Integral membrane protein TerC family
SMN_RS15740	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMN_RS15745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMN_RS15750	COG4303	Ethanolamine ammonia lyase large subunit
SMN_RS15755	COG4302	ethanolamine ammonia-lyase activity
SMN_RS15760	COG0531	amino acid
SMN_RS15765	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMN_RS15770	COG0281	malic enzyme
SMN_RS15770	COG0280	phosphate acetyltransferase
SMN_RS15775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMN_RS15785	COG0439	Biotin carboxylase
SMN_RS15790	COG0511	ligase activity, forming carbon-carbon bonds
SMN_RS15795	COG0717	Belongs to the dCTP deaminase family
SMN_RS15810	COG3041	Addiction module toxin RelE StbE family
SMN_RS15820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMN_RS15835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMN_RS15840	COG1086	Polysaccharide biosynthesis protein
SMN_RS15845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMN_RS15850	COG1083	cytidylyl-transferase
SMN_RS15860	COG2089	acid synthase
SMN_RS15880	COG0318	PFAM AMP-dependent synthetase and ligase
SMN_RS15885	COG1216	Glycosyl transferase, family 2
SMN_RS15890	COG0562	UDP-galactopyranose mutase
SMN_RS15900	COG1216	Glycosyl transferase, family 2
SMN_RS15905	COG1216	Glycosyl transferase, family 2
SMN_RS15910	COG0110	maltose O-acetyltransferase activity
SMN_RS15920	COG2226	methyltransferase
SMN_RS15950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMN_RS15955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMN_RS15960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMN_RS15965	COG0372	Belongs to the citrate synthase family
SMN_RS15985	COG0148	phosphopyruvate hydratase activity
SMN_RS15990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMN_RS15995	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMN_RS16000	COG1987	bacterial-type flagellum assembly
SMN_RS16005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMN_RS16010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMN_RS16040	COG1408	metallophosphoesterase
SMN_RS16045	COG1115	amino acid carrier protein
SMN_RS16050	COG2233	PERMEase
SMN_RS16055	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SMN_RS16060	COG0575	Belongs to the CDS family
SMN_RS16075	COG1929	Belongs to the glycerate kinase type-1 family
SMN_RS16080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMN_RS16100	COG0753	catalase activity
SMN_RS16105	COG0450	alkyl hydroperoxide reductase
SMN_RS16110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMN_RS16120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMN_RS16125	COG0746	molybdenum cofactor guanylyltransferase activity
SMN_RS16155	COG0724	RNA recognition motif
SMN_RS16160	COG0315	cyclic pyranopterin monophosphate synthase activity
SMN_RS16175	COG3328	transposase activity
SMN_RS16205	COG3328	transposase activity
SMN_RS16240	COG1140	nitrate reductase beta subunit
SMN_RS16250	COG2897	thiosulfate sulfurtransferase activity
SMN_RS16260	COG0489	protein tyrosine kinase activity
SMN_RS16335	COG0670	Belongs to the BI1 family
SMN_RS16385	COG0437	4 iron, 4 sulfur cluster binding
SMN_RS16390	COG0243	molybdopterin cofactor binding
SMN_RS16395	COG4106	trans-aconitate 2-methyltransferase activity
SMN_RS16405	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMN_RS16410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMN_RS16420	COG0233	cytoplasmic translational termination
SMN_RS16425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMN_RS16450	COG1704	LemA family
SMN_RS16455	COG1217	gtp-binding protein TYPA
SMN_RS16470	COG1749	Flagellar hook protein flgE
SMN_RS16475	COG1749	Flagellar hook protein flgE
SMN_RS16480	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SMN_RS16485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group