locus-tag	class	description
IMZ28_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IMZ28_RS00010	COG0592	DNA-directed DNA polymerase activity
IMZ28_RS00015	COG0504	CTP synthase activity
IMZ28_RS00020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IMZ28_RS00040	COG0489	protein tyrosine kinase activity
IMZ28_RS00050	COG2081	HI0933 family
IMZ28_RS00070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IMZ28_RS00075	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IMZ28_RS00110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IMZ28_RS00150	COG5002	protein histidine kinase activity
IMZ28_RS00155	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS00160	COG1442	glycosyl transferase family 8
IMZ28_RS00160	COG1216	Glycosyl transferase, family 2
IMZ28_RS00185	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IMZ28_RS00195	COG0438	transferase activity, transferring glycosyl groups
IMZ28_RS00225	COG0438	transferase activity, transferring glycosyl groups
IMZ28_RS00250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IMZ28_RS00265	COG0572	uridine kinase
IMZ28_RS00275	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS00315	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IMZ28_RS00325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IMZ28_RS00340	COG1115	amino acid carrier protein
IMZ28_RS00385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IMZ28_RS00390	COG1187	pseudouridine synthase activity
IMZ28_RS00395	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IMZ28_RS00395	COG0517	IMP dehydrogenase activity
IMZ28_RS00400	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IMZ28_RS00405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IMZ28_RS00410	COG0107	imidazoleglycerol-phosphate synthase activity
IMZ28_RS00420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IMZ28_RS00425	COG0564	pseudouridine synthase activity
IMZ28_RS00430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IMZ28_RS00435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IMZ28_RS00445	COG0372	Belongs to the citrate synthase family
IMZ28_RS00450	COG3123	guanosine phosphorylase activity
IMZ28_RS00460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IMZ28_RS00465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IMZ28_RS00470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IMZ28_RS00475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IMZ28_RS00480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IMZ28_RS00500	COG2259	Doxx family
IMZ28_RS00525	COG1451	nucleotide metabolic process
IMZ28_RS00540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IMZ28_RS00540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IMZ28_RS00545	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS00550	COG0642	Histidine kinase
IMZ28_RS00555	COG2358	TRAP transporter, solute receptor (TAXI family
IMZ28_RS00600	COG0129	dihydroxy-acid dehydratase activity
IMZ28_RS00605	COG0791	NLP P60 protein
IMZ28_RS00635	COG4974	Belongs to the 'phage' integrase family
IMZ28_RS00700	COG0732	type I restriction modification DNA specificity domain
IMZ28_RS00735	COG0051	transcription antitermination factor activity, RNA binding
IMZ28_RS00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IMZ28_RS00745	COG0088	Forms part of the polypeptide exit tunnel
IMZ28_RS00750	COG0089	rRNA binding
IMZ28_RS00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IMZ28_RS00760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IMZ28_RS00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IMZ28_RS00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IMZ28_RS00775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IMZ28_RS00780	COG0255	Belongs to the universal ribosomal protein uL29 family
IMZ28_RS00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IMZ28_RS00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IMZ28_RS00795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IMZ28_RS00800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IMZ28_RS00805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IMZ28_RS00810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IMZ28_RS00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IMZ28_RS00820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IMZ28_RS00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IMZ28_RS00830	COG0200	Binds to the 23S rRNA
IMZ28_RS00835	COG0201	protein transport
IMZ28_RS00840	COG0024	Methionine aminopeptidase
IMZ28_RS00845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IMZ28_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IMZ28_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IMZ28_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IMZ28_RS00865	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IMZ28_RS00870	COG0202	RNA polymerase activity
IMZ28_RS00875	COG0203	ribosomal protein L17
IMZ28_RS00890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IMZ28_RS00920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IMZ28_RS00925	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IMZ28_RS00940	COG0306	phosphate transporter
IMZ28_RS00945	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS00965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IMZ28_RS00975	COG0581	inorganic phosphate transmembrane transporter activity
IMZ28_RS00980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IMZ28_RS01000	COG0514	ATP-dependent DNA helicase (RecQ)
IMZ28_RS01005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IMZ28_RS01015	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IMZ28_RS01020	COG0571	ribonuclease III activity
IMZ28_RS01025	COG0328	RNA-DNA hybrid ribonuclease activity
IMZ28_RS01035	COG0358	DNA primase activity
IMZ28_RS01070	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IMZ28_RS01085	COG0318	PFAM AMP-dependent synthetase and ligase
IMZ28_RS01090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IMZ28_RS01110	COG1222	aaa ATPase
IMZ28_RS01115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IMZ28_RS01120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IMZ28_RS01125	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IMZ28_RS01130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IMZ28_RS01135	COG0649	NAD binding
IMZ28_RS01160	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IMZ28_RS01165	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IMZ28_RS01170	COG0839	Belongs to the complex I subunit 6 family
IMZ28_RS01175	COG0713	ATP synthesis coupled electron transport
IMZ28_RS01180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IMZ28_RS01190	COG1007	ATP synthesis coupled electron transport
IMZ28_RS01195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IMZ28_RS01205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IMZ28_RS01215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IMZ28_RS01230	COG0194	GDP metabolic process
IMZ28_RS01235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IMZ28_RS01240	COG0018	arginyl-trna synthetase
IMZ28_RS01255	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IMZ28_RS01260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IMZ28_RS01265	COG0126	phosphoglycerate kinase activity
IMZ28_RS01270	COG0149	triose-phosphate isomerase activity
IMZ28_RS01275	COG0195	Participates in both transcription termination and antitermination
IMZ28_RS01285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IMZ28_RS01290	COG2121	Domain of unknown function (DUF374)
IMZ28_RS01310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IMZ28_RS01330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IMZ28_RS01340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IMZ28_RS01345	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IMZ28_RS01365	COG5002	protein histidine kinase activity
IMZ28_RS01370	COG1597	lipid kinase activity
IMZ28_RS01375	COG0811	peptide transport
IMZ28_RS01400	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS01425	COG4263	nitrous-oxide reductase activity
IMZ28_RS01440	COG0437	4 iron, 4 sulfur cluster binding
IMZ28_RS01455	COG0348	domain, Protein
IMZ28_RS01460	COG1121	(ABC) transporter
IMZ28_RS01480	COG0840	transmembrane signaling receptor activity
IMZ28_RS01505	COG1136	(ABC) transporter
IMZ28_RS01520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IMZ28_RS01525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IMZ28_RS01530	COG0825	malonyl-CoA metabolic process
IMZ28_RS01535	COG0586	Pfam SNARE associated Golgi protein
IMZ28_RS01540	COG0513	Belongs to the DEAD box helicase family
IMZ28_RS01550	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IMZ28_RS01555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IMZ28_RS01560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IMZ28_RS01565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IMZ28_RS01570	COG0135	phosphoribosylanthranilate isomerase activity
IMZ28_RS01585	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IMZ28_RS01595	COG0556	nucleotide-excision repair
IMZ28_RS01610	COG4969	Belongs to the N-Me-Phe pilin family
IMZ28_RS01625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IMZ28_RS01635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IMZ28_RS01650	COG0463	Glycosyl transferase, family 2
IMZ28_RS01660	COG2165	general secretion pathway protein
IMZ28_RS01665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IMZ28_RS01675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IMZ28_RS01680	COG0305	Participates in initiation and elongation during chromosome replication
IMZ28_RS01690	COG1295	ribonuclease BN
IMZ28_RS01695	COG0277	FAD linked oxidase domain protein
IMZ28_RS01705	COG0739	heme binding
IMZ28_RS01715	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS01760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IMZ28_RS01790	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IMZ28_RS01795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IMZ28_RS01800	COG3706	GGDEF domain
IMZ28_RS01810	COG1924	4 iron, 4 sulfur cluster binding
IMZ28_RS01815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IMZ28_RS01820	COG0159	tryptophan synthase activity
IMZ28_RS01825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IMZ28_RS01830	COG2255	four-way junction helicase activity
IMZ28_RS01835	COG0628	permease
IMZ28_RS01840	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS01845	COG0642	Histidine kinase
IMZ28_RS01850	COG0247	lactate metabolic process
IMZ28_RS01855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IMZ28_RS01860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IMZ28_RS01865	COG0113	porphobilinogen synthase activity
IMZ28_RS01870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IMZ28_RS01895	COG1132	(ABC) transporter
IMZ28_RS01905	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IMZ28_RS01910	COG0367	asparagine synthase
IMZ28_RS01920	COG0357	Ribosomal RNA small subunit methyltransferase G
IMZ28_RS01935	COG0705	Rhomboid family
IMZ28_RS01950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IMZ28_RS01955	COG0540	Belongs to the ATCase OTCase family
IMZ28_RS01960	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IMZ28_RS01965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IMZ28_RS01975	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IMZ28_RS01980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IMZ28_RS01990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IMZ28_RS01995	COG0193	aminoacyl-tRNA hydrolase activity
IMZ28_RS02005	COG0019	diaminopimelate decarboxylase activity
IMZ28_RS02015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IMZ28_RS02025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IMZ28_RS02030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IMZ28_RS02040	COG0105	UTP biosynthetic process
IMZ28_RS02050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IMZ28_RS02055	COG0416	fatty acid biosynthetic process
IMZ28_RS02060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IMZ28_RS02065	COG1692	metallophosphoesterase
IMZ28_RS02070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IMZ28_RS02075	COG0495	leucyl-tRNA aminoacylation
IMZ28_RS02085	COG0285	dihydrofolate synthase activity
IMZ28_RS02090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IMZ28_RS02095	COG0714	Associated with various cellular activities
IMZ28_RS02115	COG2304	oxidoreductase activity
IMZ28_RS02130	COG0287	Prephenate dehydrogenase
IMZ28_RS02135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IMZ28_RS02145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IMZ28_RS02150	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS02160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IMZ28_RS02165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IMZ28_RS02170	COG0157	Belongs to the NadC ModD family
IMZ28_RS02175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IMZ28_RS02185	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IMZ28_RS02195	COG0083	homoserine kinase activity
IMZ28_RS02205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IMZ28_RS02210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IMZ28_RS02215	COG0779	Required for maturation of 30S ribosomal subunits
IMZ28_RS02220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IMZ28_RS02220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IMZ28_RS02230	COG1570	exodeoxyribonuclease VII activity
IMZ28_RS02235	COG5001	Diguanylate cyclase
IMZ28_RS02235	COG1716	ATPase activity
IMZ28_RS02240	COG0459	protein refolding
IMZ28_RS02245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IMZ28_RS02270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IMZ28_RS02275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IMZ28_RS02280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IMZ28_RS02285	COG2264	protein methyltransferase activity
IMZ28_RS02290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IMZ28_RS02295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IMZ28_RS02310	COG0438	transferase activity, transferring glycosyl groups
IMZ28_RS02315	COG0726	polysaccharide deacetylase
IMZ28_RS02335	COG0438	transferase activity, transferring glycosyl groups
IMZ28_RS02365	COG0529	Catalyzes the synthesis of activated sulfate
IMZ28_RS02370	COG0529	Catalyzes the synthesis of activated sulfate
IMZ28_RS02375	COG2895	sulfate adenylyltransferase (ATP) activity
IMZ28_RS02385	COG0175	sulfate reduction
IMZ28_RS02400	COG1132	(ABC) transporter
IMZ28_RS02420	COG0668	transmembrane transport
IMZ28_RS02425	COG1160	GTP binding
IMZ28_RS02450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IMZ28_RS02455	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IMZ28_RS02460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IMZ28_RS02470	COG2217	Heavy metal translocating P-type atpase
IMZ28_RS02485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IMZ28_RS02490	COG0166	Belongs to the GPI family
IMZ28_RS02505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IMZ28_RS02510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IMZ28_RS02515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IMZ28_RS02520	COG0612	Peptidase, M16
IMZ28_RS02525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IMZ28_RS02535	COG2165	general secretion pathway protein
IMZ28_RS02560	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IMZ28_RS02565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IMZ28_RS02585	COG0840	transmembrane signaling receptor activity
IMZ28_RS02590	COG0322	excinuclease ABC activity
IMZ28_RS02600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IMZ28_RS02610	COG0519	Catalyzes the synthesis of GMP from XMP
IMZ28_RS02610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IMZ28_RS02620	COG0326	Molecular chaperone. Has ATPase activity
IMZ28_RS02645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IMZ28_RS02660	COG1185	polyribonucleotide nucleotidyltransferase activity
IMZ28_RS02665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IMZ28_RS02675	COG0776	regulation of translation
IMZ28_RS02690	COG3328	transposase activity
IMZ28_RS02695	COG1592	Rubrerythrin
IMZ28_RS02700	COG2193	ferroxidase activity
IMZ28_RS02705	COG0484	heat shock protein binding
IMZ28_RS02715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IMZ28_RS02720	COG2404	hydrolase activity, acting on ester bonds
IMZ28_RS02730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IMZ28_RS02735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IMZ28_RS02740	COG0443	Heat shock 70 kDa protein
IMZ28_RS02770	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS02775	COG0642	Histidine kinase
IMZ28_RS02780	COG0517	IMP dehydrogenase activity
IMZ28_RS02795	COG1730	sister chromatid segregation
IMZ28_RS02820	COG1331	Highly conserved protein containing a thioredoxin domain
IMZ28_RS02825	COG4232	protein-disulfide reductase activity
IMZ28_RS02845	COG1981	membrane
IMZ28_RS02860	COG0101	tRNA pseudouridine synthase activity
IMZ28_RS02870	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IMZ28_RS02875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IMZ28_RS02885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IMZ28_RS02890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IMZ28_RS02895	COG1832	CoA-binding protein
IMZ28_RS02900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IMZ28_RS02910	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS02920	COG0028	Belongs to the TPP enzyme family
IMZ28_RS02925	COG0440	acetolactate synthase activity
IMZ28_RS02930	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IMZ28_RS02940	COG1366	Belongs to the anti-sigma-factor antagonist family
IMZ28_RS02945	COG0646	methionine synthase
IMZ28_RS02945	COG1410	methionine synthase
IMZ28_RS02950	COG0133	tryptophan synthase activity
IMZ28_RS02970	COG2195	Cleaves the N-terminal amino acid of tripeptides
IMZ28_RS02975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IMZ28_RS02980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IMZ28_RS02990	COG0191	fructose-bisphosphate aldolase activity
IMZ28_RS03000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IMZ28_RS03055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IMZ28_RS03060	COG0154	amidase activity
IMZ28_RS03065	COG0517	IMP dehydrogenase activity
IMZ28_RS03065	COG0516	GMP reductase activity
IMZ28_RS03075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IMZ28_RS03080	COG1722	exodeoxyribonuclease VII activity
IMZ28_RS03090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IMZ28_RS03100	COG0251	oxidation-reduction process
IMZ28_RS03105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IMZ28_RS03110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IMZ28_RS03120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IMZ28_RS03125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IMZ28_RS03130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IMZ28_RS03135	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IMZ28_RS03135	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IMZ28_RS03140	COG1192	Involved in chromosome partitioning
IMZ28_RS03145	COG1475	DNA binding
IMZ28_RS03155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IMZ28_RS03160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IMZ28_RS03165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IMZ28_RS03170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IMZ28_RS03175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IMZ28_RS03180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IMZ28_RS03185	COG0811	peptide transport
IMZ28_RS03190	COG0848	biopolymer transport protein
IMZ28_RS03215	COG1090	epimerase
IMZ28_RS03225	COG0823	Involved in the tonB-independent uptake of proteins
IMZ28_RS03245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IMZ28_RS03250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IMZ28_RS03255	COG1047	Peptidyl-prolyl cis-trans
IMZ28_RS03275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IMZ28_RS03280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IMZ28_RS03285	COG0037	tRNA processing
IMZ28_RS03290	COG0564	pseudouridine synthase activity
IMZ28_RS03295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IMZ28_RS03300	COG2884	Cell division ATP-binding protein ftsE
IMZ28_RS03315	COG0528	UMP kinase activity
IMZ28_RS03320	COG1758	RNA polymerase activity
IMZ28_RS03325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IMZ28_RS03330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IMZ28_RS03340	COG0860	N-Acetylmuramoyl-L-alanine amidase
IMZ28_RS03340	COG2247	cell wall binding repeat
IMZ28_RS03345	COG0860	N-Acetylmuramoyl-L-alanine amidase
IMZ28_RS03350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IMZ28_RS03370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IMZ28_RS03375	COG0066	3-isopropylmalate dehydratase activity
IMZ28_RS03380	COG0473	3-isopropylmalate dehydrogenase activity
IMZ28_RS03385	COG0788	formyltetrahydrofolate deformylase activity
IMZ28_RS03405	COG3706	GGDEF domain
IMZ28_RS03410	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IMZ28_RS03410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IMZ28_RS03435	COG0134	indole-3-glycerol-phosphate synthase activity
IMZ28_RS03450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IMZ28_RS03465	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IMZ28_RS03470	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IMZ28_RS03480	COG0137	argininosuccinate synthase activity
IMZ28_RS03490	COG0339	signal peptide processing
IMZ28_RS03495	COG0359	binds to the 23S rRNA
IMZ28_RS03500	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IMZ28_RS03505	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IMZ28_RS03510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IMZ28_RS03530	COG4796	Type ii and iii secretion system protein
IMZ28_RS03545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IMZ28_RS03550	COG1459	type II secretion system
IMZ28_RS03555	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IMZ28_RS03560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IMZ28_RS03570	COG1739	Uncharacterized protein family UPF0029
IMZ28_RS03580	COG0004	ammonium transporteR
IMZ28_RS03590	COG0004	ammonium transporteR
IMZ28_RS03610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IMZ28_RS03610	COG0301	tRNA thio-modification
IMZ28_RS03620	COG0243	molybdopterin cofactor binding
IMZ28_RS03625	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IMZ28_RS03635	COG2223	nitrite transmembrane transporter activity
IMZ28_RS03640	COG0515	serine threonine protein kinase
IMZ28_RS03660	COG0653	protein targeting
IMZ28_RS03700	COG0488	(ABC) transporter
IMZ28_RS03705	COG0217	transcriptional regulatory protein
IMZ28_RS03710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IMZ28_RS03720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ28_RS03730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IMZ28_RS03740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IMZ28_RS03750	COG0731	radical SAM domain protein
IMZ28_RS03765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IMZ28_RS03770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IMZ28_RS03780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IMZ28_RS03795	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IMZ28_RS03805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IMZ28_RS03815	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IMZ28_RS03820	COG1086	Polysaccharide biosynthesis protein
IMZ28_RS03825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IMZ28_RS03840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IMZ28_RS03845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IMZ28_RS03850	COG2089	acid synthase
IMZ28_RS03870	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IMZ28_RS03875	COG1088	dTDP-glucose 4,6-dehydratase activity
IMZ28_RS03890	COG1216	Glycosyl transferase, family 2
IMZ28_RS03900	COG0110	maltose O-acetyltransferase activity
IMZ28_RS03930	COG5434	Belongs to the glycosyl hydrolase 28 family
IMZ28_RS03950	COG0489	protein tyrosine kinase activity
IMZ28_RS03970	COG0588	phosphoglycerate mutase activity
IMZ28_RS03975	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IMZ28_RS03980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IMZ28_RS03995	COG1492	cobalamin metabolic process
IMZ28_RS04005	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IMZ28_RS04015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IMZ28_RS04020	COG1121	(ABC) transporter
IMZ28_RS04030	COG4206	TonB-dependent receptor
IMZ28_RS04040	COG2171	N-acyltransferase activity
IMZ28_RS04055	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IMZ28_RS04060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IMZ28_RS04065	COG0802	atpase or kinase
IMZ28_RS04070	COG1137	ATPase activity
IMZ28_RS04080	COG0356	it plays a direct role in the translocation of protons across the membrane
IMZ28_RS04090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IMZ28_RS04095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IMZ28_RS04105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IMZ28_RS04135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IMZ28_RS04140	COG0594	ribonuclease P activity
IMZ28_RS04145	COG0706	membrane insertase activity
IMZ28_RS04155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IMZ28_RS04175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IMZ28_RS04180	COG0138	bifunctional purine biosynthesis protein purh
IMZ28_RS04190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IMZ28_RS04200	COG0484	heat shock protein binding
IMZ28_RS04205	COG0789	Transcriptional regulator
IMZ28_RS04225	COG0070	glutamate synthase
IMZ28_RS04225	COG0067	glutamate synthase
IMZ28_RS04225	COG0069	glutamate synthase activity
IMZ28_RS04235	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IMZ28_RS04245	COG0778	Nitroreductase
IMZ28_RS04255	COG1942	4-Oxalocrotonate Tautomerase
IMZ28_RS04275	COG0617	tRNA 3'-terminal CCA addition
IMZ28_RS04290	COG0667	Aldo Keto reductase
IMZ28_RS04310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IMZ28_RS04315	COG2860	membrane
IMZ28_RS04325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IMZ28_RS04340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IMZ28_RS04360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IMZ28_RS04370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IMZ28_RS04375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IMZ28_RS04385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IMZ28_RS04400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IMZ28_RS04410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IMZ28_RS04410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IMZ28_RS04415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IMZ28_RS04415	COG1333	cytochrome c biogenesis protein
IMZ28_RS04425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IMZ28_RS04430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IMZ28_RS04435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IMZ28_RS04440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IMZ28_RS04455	COG2814	Major facilitator Superfamily
IMZ28_RS04470	COG0560	Phosphoserine phosphatase
IMZ28_RS04490	COG1132	(ABC) transporter
IMZ28_RS04495	COG1968	undecaprenyl-diphosphatase activity
IMZ28_RS04520	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IMZ28_RS04525	COG1022	Amp-dependent synthetase and ligase
IMZ28_RS04530	COG0183	Belongs to the thiolase family
IMZ28_RS04535	COG1024	Enoyl-CoA hydratase
IMZ28_RS04535	COG1250	3-hydroxyacyl-CoA dehydrogenase
IMZ28_RS04540	COG1960	acyl-CoA dehydrogenase activity
IMZ28_RS04560	COG2239	Acts as a magnesium transporter
IMZ28_RS04565	COG4536	flavin adenine dinucleotide binding
IMZ28_RS04570	COG0513	Belongs to the DEAD box helicase family
IMZ28_RS04580	COG0585	pseudouridine synthase activity
IMZ28_RS04595	COG1254	Belongs to the acylphosphatase family
IMZ28_RS04605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IMZ28_RS04615	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS04620	COG0642	Histidine kinase
IMZ28_RS04640	COG2010	Cytochrome c
IMZ28_RS04650	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IMZ28_RS04670	COG1959	2 iron, 2 sulfur cluster binding
IMZ28_RS04675	COG2873	o-acetylhomoserine
IMZ28_RS04680	COG0616	signal peptide processing
IMZ28_RS04685	COG0402	S-adenosylhomocysteine deaminase activity
IMZ28_RS04690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IMZ28_RS04695	COG0006	proline dipeptidase activity
IMZ28_RS04700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IMZ28_RS04705	COG1419	protein localization to endoplasmic reticulum
IMZ28_RS04715	COG0482	sulfurtransferase activity
IMZ28_RS04730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IMZ28_RS04735	COG0481	GTPase activity
IMZ28_RS04745	COG2989	Protein conserved in bacteria
IMZ28_RS04750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IMZ28_RS04770	COG0189	ligase activity
IMZ28_RS04820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IMZ28_RS04825	COG1121	(ABC) transporter
IMZ28_RS04830	COG0803	Belongs to the bacterial solute-binding protein 9 family
IMZ28_RS04855	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IMZ28_RS04880	COG0012	GTP binding
IMZ28_RS04890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IMZ28_RS04940	COG0133	tryptophan synthase activity
IMZ28_RS04945	COG0584	glycerophosphoryl diester phosphodiesterase
IMZ28_RS04950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IMZ28_RS04960	COG0698	ribose 5-phosphate isomerase
IMZ28_RS04965	COG1994	Peptidase M50
IMZ28_RS04970	COG0681	Belongs to the peptidase S26 family
IMZ28_RS04975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IMZ28_RS04985	COG1278	Cold shock
IMZ28_RS05015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IMZ28_RS05015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IMZ28_RS05020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IMZ28_RS05025	COG0284	orotidine-5'-phosphate decarboxylase activity
IMZ28_RS05040	COG3300	MHYT domain
IMZ28_RS05040	COG5001	Diguanylate cyclase
IMZ28_RS05050	COG0525	valine-tRNA ligase activity
IMZ28_RS05075	COG0069	glutamate synthase activity
IMZ28_RS05090	COG0205	6-phosphofructokinase activity
IMZ28_RS05095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IMZ28_RS05100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IMZ28_RS05105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IMZ28_RS05110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IMZ28_RS05115	COG1283	sodium-dependent phosphate transmembrane transporter activity
IMZ28_RS05125	COG2863	cytochrome
IMZ28_RS05130	COG0642	Histidine kinase
IMZ28_RS05135	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS05170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IMZ28_RS05175	COG0204	Acyl-transferase
IMZ28_RS05185	COG0047	phosphoribosylformylglycinamidine synthase activity
IMZ28_RS05190	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IMZ28_RS05195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IMZ28_RS05200	COG0793	Belongs to the peptidase S41A family
IMZ28_RS05205	COG0542	response to heat
IMZ28_RS05230	COG1013	pyruvate-flavodoxin oxidoreductase activity
IMZ28_RS05240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IMZ28_RS05265	COG1518	maintenance of DNA repeat elements
IMZ28_RS05280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IMZ28_RS05280	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IMZ28_RS05300	COG3162	membrane
IMZ28_RS05305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IMZ28_RS05310	COG0517	IMP dehydrogenase activity
IMZ28_RS05310	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IMZ28_RS05315	COG2176	DNA-directed DNA polymerase activity
IMZ28_RS05320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IMZ28_RS05325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IMZ28_RS05330	COG1573	uracil-dna glycosylase
IMZ28_RS05335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IMZ28_RS05335	COG0574	Belongs to the PEP-utilizing enzyme family
IMZ28_RS05345	COG3021	interspecies interaction between organisms
IMZ28_RS05405	COG0531	amino acid
IMZ28_RS05420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IMZ28_RS05420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IMZ28_RS05425	COG2827	Endonuclease containing a URI domain
IMZ28_RS05440	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IMZ28_RS05445	COG1763	Mo-molybdopterin cofactor biosynthetic process
IMZ28_RS05460	COG0762	integral membrane protein
IMZ28_RS05465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IMZ28_RS05475	COG2176	DNA-directed DNA polymerase activity
IMZ28_RS05490	COG0688	phosphatidylethanolamine metabolic process
IMZ28_RS05530	COG1309	transcriptional regulator
IMZ28_RS05540	COG3647	Membrane
IMZ28_RS05560	COG3177	Filamentation induced by cAMP protein fic
IMZ28_RS05575	COG2081	HI0933 family
IMZ28_RS05585	COG0742	ribosomal rna small subunit methyltransferase
IMZ28_RS05615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IMZ28_RS05620	COG2954	triphosphatase activity
IMZ28_RS05625	COG0585	pseudouridine synthase activity
IMZ28_RS05705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IMZ28_RS05720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IMZ28_RS05720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IMZ28_RS05730	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IMZ28_RS05750	COG2048	Heterodisulfide reductase, subunit B
IMZ28_RS05770	COG4948	Mandelate Racemase Muconate Lactonizing
IMZ28_RS05775	COG0659	secondary active sulfate transmembrane transporter activity
IMZ28_RS05780	COG3850	Histidine kinase
IMZ28_RS05780	COG3437	response regulator, receiver
IMZ28_RS05780	COG2205	protein histidine kinase activity
IMZ28_RS05780	COG4999	Histidine kinase
IMZ28_RS05800	COG0521	Mo-molybdopterin cofactor biosynthetic process
IMZ28_RS05805	COG0300	oxidoreductase activity
IMZ28_RS05810	COG0628	permease
IMZ28_RS05830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IMZ28_RS05835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IMZ28_RS05845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IMZ28_RS05855	COG0343	queuine tRNA-ribosyltransferase activity
IMZ28_RS05860	COG2226	methyltransferase
IMZ28_RS05875	COG1704	LemA family
IMZ28_RS05910	COG2203	Gaf domain
IMZ28_RS05910	COG3706	GGDEF domain
IMZ28_RS05910	COG4251	negative regulation of phosphorylation
IMZ28_RS05910	COG5001	Diguanylate cyclase
IMZ28_RS05925	COG0561	phosphatase activity
IMZ28_RS05930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IMZ28_RS05955	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS05960	COG0642	Histidine kinase
IMZ28_RS05965	COG3178	'Phosphotransferase
IMZ28_RS05970	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IMZ28_RS06015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IMZ28_RS06035	COG1757	Na H antiporter
IMZ28_RS06050	COG2062	phosphohistidine phosphatase, SixA
IMZ28_RS06055	COG1796	DNA polymerase
IMZ28_RS06055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IMZ28_RS06060	COG2078	PFAM AMMECR1 domain protein
IMZ28_RS06060	COG3885	ferrous iron binding
IMZ28_RS06065	COG1355	regulation of microtubule-based process
IMZ28_RS06075	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IMZ28_RS06080	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IMZ28_RS06085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IMZ28_RS06090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IMZ28_RS06095	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IMZ28_RS06100	COG1077	Cell shape determining protein MreB Mrl
IMZ28_RS06110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IMZ28_RS06125	COG0500	methyltransferase
IMZ28_RS06140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IMZ28_RS06150	COG4895	conserved protein (DUF2196)
IMZ28_RS06155	COG1671	Belongs to the UPF0178 family
IMZ28_RS06160	COG0708	Exodeoxyribonuclease III
IMZ28_RS06185	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IMZ28_RS06225	COG0642	Histidine kinase
IMZ28_RS06230	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS06235	COG1943	Transposase
IMZ28_RS06245	COG3177	Filamentation induced by cAMP protein fic
IMZ28_RS06270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IMZ28_RS06280	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IMZ28_RS06300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IMZ28_RS06305	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IMZ28_RS06315	COG0768	penicillin binding
IMZ28_RS06330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IMZ28_RS06345	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IMZ28_RS06350	COG0131	Imidazoleglycerol-phosphate dehydratase
IMZ28_RS06355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IMZ28_RS06360	COG0084	hydrolase, TatD family'
IMZ28_RS06370	COG0497	DNA recombination
IMZ28_RS06375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IMZ28_RS06380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IMZ28_RS06385	COG0563	adenylate kinase activity
IMZ28_RS06395	COG0123	including yeast histone deacetylase and acetoin utilization protein
IMZ28_RS06425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IMZ28_RS06425	COG3008	intermembrane lipid transfer
IMZ28_RS06430	COG2995	paraquat-inducible protein a
IMZ28_RS06440	COG1597	lipid kinase activity
IMZ28_RS06445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IMZ28_RS06460	COG2951	lytic endotransglycosylase activity
IMZ28_RS06470	COG0642	Histidine kinase
IMZ28_RS06475	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS06495	COG2132	Multicopper oxidase
IMZ28_RS06535	COG3746	phosphate-selective porin O and P
IMZ28_RS06540	COG0803	Belongs to the bacterial solute-binding protein 9 family
IMZ28_RS06570	COG0824	Thioesterase
IMZ28_RS06585	COG0375	protein maturation
IMZ28_RS06590	COG1024	Enoyl-CoA hydratase
IMZ28_RS06590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IMZ28_RS06595	COG0309	Hydrogenase expression formation protein (HypE)
IMZ28_RS06600	COG0409	Hydrogenase expression formation protein
IMZ28_RS06605	COG0298	carbon dioxide binding
IMZ28_RS06610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IMZ28_RS06630	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IMZ28_RS06635	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IMZ28_RS06660	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IMZ28_RS06675	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
IMZ28_RS06680	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IMZ28_RS06685	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IMZ28_RS06695	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IMZ28_RS06700	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
IMZ28_RS06705	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IMZ28_RS06710	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IMZ28_RS06720	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IMZ28_RS06725	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IMZ28_RS06725	COG3261	NADH dehydrogenase
IMZ28_RS06740	COG0375	protein maturation
IMZ28_RS06745	COG0493	'glutamate synthase
IMZ28_RS06745	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IMZ28_RS06770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IMZ28_RS06780	COG0437	4 iron, 4 sulfur cluster binding
IMZ28_RS06800	COG1309	transcriptional regulator
IMZ28_RS06860	COG1049	propionate catabolic process, 2-methylcitrate cycle
IMZ28_RS06865	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IMZ28_RS06870	COG1674	ftsk spoiiie
IMZ28_RS06870	COG1196	nuclear chromosome segregation
IMZ28_RS06890	COG0719	Fe-S assembly protein
IMZ28_RS06895	COG0396	ATPase activity
IMZ28_RS06900	COG0719	Fe-S assembly protein
IMZ28_RS06905	COG2166	iron-sulfur cluster assembly
IMZ28_RS06910	COG2151	metal-sulfur cluster biosynthetic enzyme
IMZ28_RS06915	COG0163	prenyltransferase activity
IMZ28_RS06920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IMZ28_RS06925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IMZ28_RS06930	COG0124	histidyl-tRNA synthetase
IMZ28_RS06945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IMZ28_RS06950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IMZ28_RS06955	COG1166	arginine decarboxylase activity
IMZ28_RS06960	COG1045	serine acetyltransferase
IMZ28_RS06990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IMZ28_RS07005	COG1496	oxidoreductase activity
IMZ28_RS07010	COG0772	Belongs to the SEDS family
IMZ28_RS07165	COG0437	4 iron, 4 sulfur cluster binding
IMZ28_RS07180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IMZ28_RS07185	COG2895	sulfate adenylyltransferase (ATP) activity
IMZ28_RS07190	COG0175	sulfate reduction
IMZ28_RS07195	COG0175	sulfate reduction
IMZ28_RS07200	COG0175	sulfate reduction
IMZ28_RS07215	COG5002	protein histidine kinase activity
IMZ28_RS07220	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS07225	COG5001	Diguanylate cyclase
IMZ28_RS07225	COG5002	protein histidine kinase activity
IMZ28_RS07240	COG1305	Transglutaminase-like
IMZ28_RS07295	COG3842	ATPase activity
IMZ28_RS07300	COG0725	ABC transporter, periplasmic molybdate-binding protein
IMZ28_RS07315	COG0303	'Molybdopterin
IMZ28_RS07325	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IMZ28_RS07335	COG0437	4 iron, 4 sulfur cluster binding
IMZ28_RS07365	COG4191	Histidine kinase
IMZ28_RS07370	COG2204	response regulator
IMZ28_RS07385	COG1921	L-seryl-tRNASec selenium transferase activity
IMZ28_RS07395	COG0583	DNA-binding transcription factor activity
IMZ28_RS07415	COG1368	sulfuric ester hydrolase activity
IMZ28_RS07420	COG0439	Biotin carboxylase
IMZ28_RS07430	COG1136	(ABC) transporter
IMZ28_RS07460	COG2824	Alkylphosphonate utilization operon protein PhnA
IMZ28_RS07465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ28_RS07480	COG3001	Fructosamine kinase
IMZ28_RS07490	COG0714	Associated with various cellular activities
IMZ28_RS07500	COG3657	addiction module killer protein
IMZ28_RS07505	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IMZ28_RS07545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IMZ28_RS07555	COG2026	Addiction module toxin, RelE StbE family
IMZ28_RS07575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IMZ28_RS07585	COG3034	peptidoglycan biosynthetic process
IMZ28_RS07590	COG2989	Protein conserved in bacteria
IMZ28_RS07595	COG2081	HI0933 family
IMZ28_RS07605	COG0791	NLP P60 protein
IMZ28_RS07605	COG1388	LysM domain
IMZ28_RS07620	COG0632	four-way junction helicase activity
IMZ28_RS07625	COG0728	peptidoglycan biosynthetic process
IMZ28_RS07630	COG0215	cysteine-tRNA ligase activity
IMZ28_RS07635	COG0167	dihydroorotate dehydrogenase activity
IMZ28_RS07640	COG0612	Peptidase, M16
IMZ28_RS07645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IMZ28_RS07650	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ28_RS07655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IMZ28_RS07665	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IMZ28_RS07685	COG0750	zinc metalloprotease
IMZ28_RS07690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IMZ28_RS07695	COG0735	belongs to the Fur family
IMZ28_RS07700	COG0450	alkyl hydroperoxide reductase
IMZ28_RS07705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IMZ28_RS07710	COG0181	hydroxymethylbilane synthase activity
IMZ28_RS07725	COG0442	prolyl-tRNA aminoacylation
IMZ28_RS07730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IMZ28_RS07735	COG0142	geranyltranstransferase activity
IMZ28_RS07745	COG3287	FIST C domain
IMZ28_RS07745	COG2200	EAL domain
IMZ28_RS07745	COG2199	diguanylate cyclase activity
IMZ28_RS07765	COG0513	Belongs to the DEAD box helicase family
IMZ28_RS07780	COG0275	rRNA processing
IMZ28_RS07800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IMZ28_RS07805	COG0849	cell division
IMZ28_RS07820	COG0754	glutathionylspermidine amidase activity
IMZ28_RS07830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IMZ28_RS07845	COG1490	D-aminoacyl-tRNA deacylase activity
IMZ28_RS07855	COG0501	Belongs to the peptidase M48B family
IMZ28_RS07860	COG0488	(ABC) transporter
IMZ28_RS07865	COG1388	LysM domain
IMZ28_RS07865	COG4932	domain protein
IMZ28_RS07870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IMZ28_RS07875	COG5001	Diguanylate cyclase
IMZ28_RS07875	COG3300	MHYT domain
IMZ28_RS07880	COG1858	cytochrome C peroxidase
IMZ28_RS07885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IMZ28_RS07895	COG2833	Protein of unknown function (DUF455)
IMZ28_RS07905	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IMZ28_RS07905	COG2050	protein possibly involved in aromatic compounds catabolism
IMZ28_RS07910	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS07915	COG0500	methyltransferase
IMZ28_RS07930	COG1418	mRNA catabolic process
IMZ28_RS07945	COG0552	protein localization to endoplasmic reticulum
IMZ28_RS07955	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IMZ28_RS07960	COG0736	holo-[acyl-carrier-protein] synthase activity
IMZ28_RS07980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IMZ28_RS07985	COG1984	allophanate hydrolase subunit 2
IMZ28_RS07995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IMZ28_RS08000	COG0243	molybdopterin cofactor binding
IMZ28_RS08045	COG1013	pyruvate-flavodoxin oxidoreductase activity
IMZ28_RS08050	COG0674	pyruvate-flavodoxin oxidoreductase activity
IMZ28_RS08050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IMZ28_RS08065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IMZ28_RS08070	COG0045	succinate-CoA ligase (ADP-forming) activity
IMZ28_RS08075	COG0114	fumarate hydratase activity
IMZ28_RS08080	COG0039	L-malate dehydrogenase activity
IMZ28_RS08085	COG0039	L-malate dehydrogenase activity
IMZ28_RS08100	COG0587	DNA-directed DNA polymerase activity
IMZ28_RS08110	COG0693	protein deglycase activity
IMZ28_RS08120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IMZ28_RS08125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IMZ28_RS08135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IMZ28_RS08145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IMZ28_RS08150	COG1185	polyribonucleotide nucleotidyltransferase activity
IMZ28_RS08150	COG0539	negative regulation of cytoplasmic translation
IMZ28_RS08155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IMZ28_RS08160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IMZ28_RS08165	COG0072	phenylalanine-tRNA ligase activity
IMZ28_RS08165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IMZ28_RS08170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IMZ28_RS08175	COG0537	adenosine 5'-monophosphoramidase activity
IMZ28_RS08180	COG0488	(ABC) transporter
IMZ28_RS08210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IMZ28_RS08215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IMZ28_RS08225	COG0165	Argininosuccinate lyase
IMZ28_RS08265	COG0512	Glutamine amidotransferase of anthranilate synthase
IMZ28_RS08270	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IMZ28_RS08275	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IMZ28_RS08280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IMZ28_RS08310	COG0352	thiamine-phosphate diphosphorylase activity
IMZ28_RS08310	COG0351	phosphomethylpyrimidine kinase
IMZ28_RS08310	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IMZ28_RS08320	COG2022	thiamine diphosphate biosynthetic process
IMZ28_RS08335	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IMZ28_RS08350	COG0514	ATP-dependent DNA helicase (RecQ)
IMZ28_RS08360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IMZ28_RS08365	COG2132	Multicopper oxidase
IMZ28_RS08365	COG2132	Multicopper oxidase
IMZ28_RS08375	COG0489	protein tyrosine kinase activity
IMZ28_RS08380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IMZ28_RS08380	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IMZ28_RS08385	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS08390	COG2046	Belongs to the sulfate adenylyltransferase family
IMZ28_RS08405	COG1160	GTP binding
IMZ28_RS08415	COG0281	malic enzyme
IMZ28_RS08415	COG0280	phosphate acetyltransferase
IMZ28_RS08455	COG5002	protein histidine kinase activity
IMZ28_RS08465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IMZ28_RS08480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IMZ28_RS08485	COG1393	Belongs to the ArsC family
IMZ28_RS08505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IMZ28_RS08510	COG0475	glutathione-regulated potassium exporter activity
IMZ28_RS08515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IMZ28_RS08525	COG3647	Membrane
IMZ28_RS08530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IMZ28_RS08565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IMZ28_RS08570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IMZ28_RS08600	COG0737	Belongs to the 5'-nucleotidase family
IMZ28_RS08625	COG0642	Histidine kinase
IMZ28_RS08645	COG0745	RESPONSE REGULATOR receiver
IMZ28_RS08650	COG0642	Histidine kinase
IMZ28_RS08655	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IMZ28_RS08660	COG2226	methyltransferase
IMZ28_RS08670	COG0196	riboflavin kinase activity
IMZ28_RS08680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IMZ28_RS08685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IMZ28_RS08705	COG0527	aspartate kinase activity
IMZ28_RS08710	COG0494	nUDIX hydrolase
IMZ28_RS08715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IMZ28_RS08720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IMZ28_RS08725	COG0805	protein transport
IMZ28_RS08725	COG0805	protein transport
IMZ28_RS08730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IMZ28_RS08735	COG0791	NLP P60 protein
IMZ28_RS08740	COG0791	NLP P60 protein
IMZ28_RS08750	COG4999	Histidine kinase
IMZ28_RS08750	COG3437	response regulator, receiver
IMZ28_RS08750	COG2205	protein histidine kinase activity
IMZ28_RS08750	COG3850	Histidine kinase
IMZ28_RS08755	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IMZ28_RS08795	COG1309	transcriptional regulator
IMZ28_RS08805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ28_RS08820	COG0471	metal ion transport
IMZ28_RS08830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IMZ28_RS08855	COG0501	Belongs to the peptidase M48B family
IMZ28_RS08860	COG0579	oxidoreductase
IMZ28_RS08865	COG0557	exoribonuclease II activity
IMZ28_RS08885	COG1466	dna polymerase III delta subunit
IMZ28_RS08890	COG0360	Binds together with S18 to 16S ribosomal RNA
IMZ28_RS08895	COG0629	single-stranded DNA binding
IMZ28_RS08900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IMZ28_RS08910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IMZ28_RS08915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IMZ28_RS08925	COG4974	Belongs to the 'phage' integrase family
IMZ28_RS08940	COG1193	negative regulation of DNA recombination
IMZ28_RS08950	COG2755	lipolytic protein G-D-S-L family
IMZ28_RS08965	COG0436	Aminotransferase
IMZ28_RS08970	COG2027	D-alanyl-D-alanine carboxypeptidase
IMZ28_RS08975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IMZ28_RS08980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IMZ28_RS08990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IMZ28_RS08995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IMZ28_RS09000	COG1862	Preprotein translocase
IMZ28_RS09005	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IMZ28_RS09015	COG0418	dihydroorotase activity
IMZ28_RS09020	COG0288	reversible hydration of carbon dioxide
IMZ28_RS09030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IMZ28_RS09040	COG0583	DNA-binding transcription factor activity
IMZ28_RS09050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IMZ28_RS09055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IMZ28_RS09065	COG0071	Belongs to the small heat shock protein (HSP20) family
IMZ28_RS09085	COG0564	pseudouridine synthase activity
IMZ28_RS09090	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IMZ28_RS09115	COG1215	transferase activity, transferring glycosyl groups
IMZ28_RS09130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IMZ28_RS09145	COG0335	large ribosomal subunit rRNA binding
IMZ28_RS09150	COG0336	Belongs to the RNA methyltransferase TrmD family
IMZ28_RS09155	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IMZ28_RS09160	COG1837	Belongs to the UPF0109 family
IMZ28_RS09165	COG0228	four-way junction DNA binding
IMZ28_RS09175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IMZ28_RS09180	COG0564	pseudouridine synthase activity
IMZ28_RS09190	COG1519	Transferase
IMZ28_RS09190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IMZ28_RS09200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IMZ28_RS09205	COG0752	glycyl-tRNA synthetase alpha subunit
IMZ28_RS09215	COG0826	peptidase U32
IMZ28_RS09220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IMZ28_RS09225	COG0174	glutamine synthetase
IMZ28_RS09245	COG0156	8-amino-7-oxononanoate synthase activity
IMZ28_RS09250	COG0424	maF-like protein
IMZ28_RS09255	COG1276	copper resistance
IMZ28_RS09260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IMZ28_RS09270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IMZ28_RS09275	COG0772	Belongs to the SEDS family
IMZ28_RS09280	COG0768	penicillin binding
IMZ28_RS09285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IMZ28_RS09290	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IMZ28_RS09310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IMZ28_RS09315	COG0052	Belongs to the universal ribosomal protein uS2 family
IMZ28_RS09320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IMZ28_RS09335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IMZ28_RS09350	COG1012	belongs to the aldehyde dehydrogenase family
IMZ28_RS09390	COG3043	anaerobic respiration
IMZ28_RS09400	COG0348	domain, Protein
IMZ28_RS09405	COG0437	4 iron, 4 sulfur cluster binding
IMZ28_RS09410	COG0243	molybdopterin cofactor binding
IMZ28_RS09415	COG2151	metal-sulfur cluster biosynthetic enzyme
IMZ28_RS09435	COG1522	sequence-specific DNA binding
IMZ28_RS09450	COG0535	radical SAM domain protein
IMZ28_RS09460	COG0303	'Molybdopterin
IMZ28_RS09470	COG0671	phosphoesterase, PA-phosphatase related
IMZ28_RS09475	COG1858	cytochrome C peroxidase
IMZ28_RS09510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IMZ28_RS09520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IMZ28_RS09530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IMZ28_RS09535	COG0569	domain protein
IMZ28_RS09545	COG2010	Cytochrome c
IMZ28_RS09555	COG3256	nitric oxide reductase
IMZ28_RS09595	COG0140	phosphoribosyl-ATP diphosphatase activity
IMZ28_RS09595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IMZ28_RS09605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IMZ28_RS09610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IMZ28_RS09615	COG0492	ferredoxin-NADP+ reductase activity
IMZ28_RS09620	COG3118	belongs to the thioredoxin family
IMZ28_RS09630	COG0792	nuclease activity
IMZ28_RS09635	COG3383	formate dehydrogenase (NAD+) activity
IMZ28_RS09645	COG1666	GTP binding
IMZ28_RS09650	COG0460	homoserine dehydrogenase
IMZ28_RS09655	COG0436	Aminotransferase
IMZ28_RS09665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IMZ28_RS09670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IMZ28_RS09675	COG0254	rRNA binding
IMZ28_RS09700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IMZ28_RS09710	COG0720	synthase
IMZ28_RS09715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IMZ28_RS09745	COG1342	Belongs to the UPF0251 family
IMZ28_RS09755	COG1271	oxidase subunit
IMZ28_RS09760	COG1294	oxidase, subunit
IMZ28_RS09770	COG0602	queuosine metabolic process
IMZ28_RS09775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IMZ28_RS09780	COG2857	Cytochrome c1
IMZ28_RS09785	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IMZ28_RS09790	COG0723	plastoquinol--plastocyanin reductase activity
IMZ28_RS09800	COG0445	tRNA wobble uridine modification
IMZ28_RS09820	COG1854	S-ribosylhomocysteine lyase activity
IMZ28_RS09825	COG1013	pyruvate-flavodoxin oxidoreductase activity
IMZ28_RS09830	COG0674	pyruvate-flavodoxin oxidoreductase activity
IMZ28_RS09835	COG1144	Oxidoreductase
IMZ28_RS09840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IMZ28_RS09845	COG0546	phosphoglycolate phosphatase activity
IMZ28_RS09850	COG4172	Belongs to the ABC transporter superfamily
IMZ28_RS09855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IMZ28_RS09880	COG0242	peptide deformylase activity
IMZ28_RS09885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IMZ28_RS09890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IMZ28_RS09895	COG1074	ATP-dependent DNA helicase activity
IMZ28_RS09925	COG2010	Cytochrome c
IMZ28_RS09940	COG3278	Belongs to the heme-copper respiratory oxidase family
IMZ28_RS09945	COG1181	Belongs to the D-alanine--D-alanine ligase family
IMZ28_RS09950	COG0505	Belongs to the CarA family
IMZ28_RS09960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IMZ28_RS09965	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IMZ28_RS09970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IMZ28_RS09980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IMZ28_RS09985	COG2814	Major facilitator Superfamily
IMZ28_RS09995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IMZ28_RS10010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IMZ28_RS10025	COG0534	Mate efflux family protein
IMZ28_RS10035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IMZ28_RS10040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IMZ28_RS10040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IMZ28_RS10045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IMZ28_RS10050	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IMZ28_RS10055	COG0432	Pfam Uncharacterised protein family UPF0047
IMZ28_RS10060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IMZ28_RS10065	COG1053	succinate dehydrogenase
IMZ28_RS10075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IMZ28_RS10085	COG0575	Belongs to the CDS family
IMZ28_RS10090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IMZ28_RS10100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IMZ28_RS10105	COG0187	DNA topoisomerase II activity
IMZ28_RS10110	COG2203	Gaf domain
IMZ28_RS10110	COG5001	Diguanylate cyclase
IMZ28_RS10110	COG4251	negative regulation of phosphorylation
IMZ28_RS10110	COG3706	GGDEF domain
IMZ28_RS10115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IMZ28_RS10130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IMZ28_RS10135	COG0049	tRNA binding
IMZ28_RS10140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IMZ28_RS10145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IMZ28_RS10150	COG0085	RNA polymerase activity
IMZ28_RS10155	COG0222	ribosome binding
IMZ28_RS10160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IMZ28_RS10165	COG0081	regulation of translation
IMZ28_RS10170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IMZ28_RS10175	COG0250	Participates in transcription elongation, termination and antitermination
IMZ28_RS10190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IMZ28_RS10195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IMZ28_RS10220	COG3022	response to hydroperoxide
IMZ28_RS10225	COG0023	Translation Initiation Factor
IMZ28_RS10250	COG1331	Highly conserved protein containing a thioredoxin domain
IMZ28_RS10270	COG0303	'Molybdopterin
IMZ28_RS10275	COG0314	molybdopterin synthase activity
IMZ28_RS10290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IMZ28_RS10295	COG1555	photosystem II stabilization
IMZ28_RS10300	COG1086	Polysaccharide biosynthesis protein
IMZ28_RS10305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IMZ28_RS10320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IMZ28_RS10330	COG0438	transferase activity, transferring glycosyl groups
IMZ28_RS10365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IMZ28_RS10370	COG0717	Belongs to the dCTP deaminase family
IMZ28_RS10375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IMZ28_RS10380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IMZ28_RS10400	COG0148	phosphopyruvate hydratase activity
IMZ28_RS10405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IMZ28_RS10410	COG1122	ATPase activity
IMZ28_RS10420	COG0310	cobalt ion transport
IMZ28_RS10445	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IMZ28_RS10450	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IMZ28_RS10455	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IMZ28_RS10460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IMZ28_RS10470	COG3034	peptidoglycan biosynthetic process
IMZ28_RS10485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IMZ28_RS10510	COG0348	domain, Protein
IMZ28_RS10520	COG0315	cyclic pyranopterin monophosphate synthase activity
IMZ28_RS10540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IMZ28_RS10545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IMZ28_RS10550	COG0268	Binds directly to 16S ribosomal RNA
IMZ28_RS10555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IMZ28_RS10560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IMZ28_RS10585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IMZ28_RS10630	COG0670	Belongs to the BI1 family
IMZ28_RS10635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IMZ28_RS10640	COG0233	cytoplasmic translational termination
IMZ28_RS10645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IMZ28_RS10670	COG3031	protein transport across the cell outer membrane
IMZ28_RS10695	COG2165	general secretion pathway protein
IMZ28_RS10725	COG2814	Major facilitator Superfamily
IMZ28_RS10730	COG0746	molybdenum cofactor guanylyltransferase activity
IMZ28_RS10735	COG0583	DNA-binding transcription factor activity
IMZ28_RS10740	COG2855	membrane
IMZ28_RS10755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IMZ28_RS10760	COG0237	dephospho-CoA kinase activity
IMZ28_RS10765	COG2989	Protein conserved in bacteria
IMZ28_RS10775	COG2304	oxidoreductase activity
IMZ28_RS10785	COG0714	Associated with various cellular activities
IMZ28_RS10800	COG0387	Pfam Sodium calcium exchanger
IMZ28_RS10810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IMZ28_RS10820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IMZ28_RS10830	COG1194	a g-specific adenine glycosylase
IMZ28_RS10845	COG1104	cysteine desulfurase activity
IMZ28_RS10850	COG0822	iron-sulfur transferase activity
IMZ28_RS10850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IMZ28_RS10850	COG2906	2 iron, 2 sulfur cluster binding
IMZ28_RS10915	COG0740	serine-type endopeptidase activity
IMZ28_RS10920	COG0544	peptidyl-prolyl cis-trans isomerase activity
IMZ28_RS10925	COG1217	gtp-binding protein TYPA
IMZ28_RS10930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IMZ28_RS10935	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IMZ28_RS10940	COG2989	Protein conserved in bacteria
IMZ28_RS10945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group