locus-tag	class	description
O1A01_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O1A01_RS00010	COG0592	DNA-directed DNA polymerase activity
O1A01_RS00015	COG2501	S4 domain
O1A01_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O1A01_RS00030	COG0187	DNA topoisomerase II activity
O1A01_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O1A01_RS00040	COG2199	diguanylate cyclase activity
O1A01_RS00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O1A01_RS00075	COG0516	GMP reductase activity
O1A01_RS00075	COG0517	IMP dehydrogenase activity
O1A01_RS00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
O1A01_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
O1A01_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O1A01_RS00105	COG1428	Deoxynucleoside kinase
O1A01_RS00110	COG1428	Deoxynucleoside kinase
O1A01_RS00115	COG1335	isochorismatase
O1A01_RS00120	COG0590	tRNA wobble adenosine to inosine editing
O1A01_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O1A01_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O1A01_RS00185	COG1982	Orn Lys Arg decarboxylase major
O1A01_RS00190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O1A01_RS00195	COG3870	Protein conserved in bacteria
O1A01_RS00200	COG1728	Protein conserved in bacteria
O1A01_RS00205	COG0470	DNA polymerase III
O1A01_RS00210	COG1774	PSP1 C-terminal conserved region
O1A01_RS00215	COG4467	Involved in initiation control of chromosome replication
O1A01_RS00220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O1A01_RS00225	COG2827	Endonuclease containing a URI domain
O1A01_RS00230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O1A01_RS00235	COG2002	toxin-antitoxin pair type II binding
O1A01_RS00245	COG0084	hydrolase, TatD family'
O1A01_RS00250	COG3584	3D domain protein
O1A01_RS00250	COG3583	domain protein
O1A01_RS00255	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O1A01_RS00260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O1A01_RS00270	COG4466	Protein conserved in bacteria
O1A01_RS00280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O1A01_RS00285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O1A01_RS00290	COG0251	oxidation-reduction process
O1A01_RS00300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O1A01_RS00310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O1A01_RS00315	COG3547	Transposase (IS116 IS110 IS902 family)
O1A01_RS00330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O1A01_RS00335	COG2002	toxin-antitoxin pair type II binding
O1A01_RS00340	COG2244	polysaccharide biosynthetic process
O1A01_RS00345	COG3956	TIGRFAM MazG family protein
O1A01_RS00350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
O1A01_RS00370	COG1098	S1 RNA binding domain
O1A01_RS00385	COG2208	phosphoserine phosphatase activity
O1A01_RS00390	COG2304	oxidoreductase activity
O1A01_RS00395	COG0515	serine threonine protein kinase
O1A01_RS00405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
O1A01_RS00410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O1A01_RS00415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O1A01_RS00420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O1A01_RS00425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O1A01_RS00430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O1A01_RS00435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O1A01_RS00440	COG0512	Glutamine amidotransferase of anthranilate synthase
O1A01_RS00445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O1A01_RS00450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O1A01_RS00455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O1A01_RS00460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O1A01_RS00465	COG1396	sequence-specific DNA binding
O1A01_RS00470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O1A01_RS00560	COG3880	PFAM UvrB UvrC protein
O1A01_RS00565	COG3869	Catalyzes the specific phosphorylation of arginine residues in
O1A01_RS00570	COG0542	response to heat
O1A01_RS00580	COG4974	Belongs to the 'phage' integrase family
O1A01_RS00600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O1A01_RS00630	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
O1A01_RS00635	COG0732	type I restriction modification DNA specificity domain
O1A01_RS00640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
O1A01_RS00665	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
O1A01_RS00670	COG4956	integral membrane protein (PIN domain superfamily)
O1A01_RS00675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O1A01_RS00680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O1A01_RS00685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O1A01_RS00690	COG1045	serine acetyltransferase
O1A01_RS00695	COG0215	cysteine-tRNA ligase activity
O1A01_RS00705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O1A01_RS00710	COG3688	RNA-binding protein containing a PIN domain
O1A01_RS00720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O1A01_RS00725	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O1A01_RS00730	COG0250	Participates in transcription elongation, termination and antitermination
O1A01_RS00735	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O1A01_RS00740	COG0081	regulation of translation
O1A01_RS00745	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O1A01_RS00750	COG0222	ribosome binding
O1A01_RS00755	COG2813	Specifically methylates the guanine in position
O1A01_RS00760	COG0085	RNA polymerase activity
O1A01_RS00770	COG1358	cellular component organization or biogenesis
O1A01_RS00775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O1A01_RS00785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O1A01_RS00790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O1A01_RS00795	COG0051	transcription antitermination factor activity, RNA binding
O1A01_RS00800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O1A01_RS00805	COG0088	Forms part of the polypeptide exit tunnel
O1A01_RS00810	COG0089	rRNA binding
O1A01_RS00815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O1A01_RS00820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O1A01_RS00835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O1A01_RS00840	COG0255	Belongs to the universal ribosomal protein uL29 family
O1A01_RS00845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O1A01_RS00850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O1A01_RS00855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O1A01_RS00860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O1A01_RS00865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O1A01_RS00870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O1A01_RS00875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O1A01_RS00880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O1A01_RS00885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O1A01_RS00890	COG1841	ribosomal large subunit assembly
O1A01_RS00895	COG0200	Binds to the 23S rRNA
O1A01_RS00900	COG0201	protein transport
O1A01_RS00905	COG0563	adenylate kinase activity
O1A01_RS00910	COG0024	Methionine aminopeptidase
O1A01_RS00920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O1A01_RS00925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O1A01_RS00930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O1A01_RS00935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O1A01_RS00945	COG0203	ribosomal protein L17
O1A01_RS00950	COG1122	ATPase activity
O1A01_RS00960	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O1A01_RS00965	COG0101	tRNA pseudouridine synthase activity
O1A01_RS00970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O1A01_RS00975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O1A01_RS00980	COG1216	Glycosyl transferase, family 2
O1A01_RS00990	COG0655	NAD(P)H dehydrogenase (quinone) activity
O1A01_RS01005	COG0860	N-Acetylmuramoyl-L-alanine amidase
O1A01_RS01010	COG0489	protein tyrosine kinase activity
O1A01_RS01020	COG2194	sulfuric ester hydrolase activity
O1A01_RS01025	COG0726	polysaccharide deacetylase
O1A01_RS01095	COG1595	DNA-templated transcription, initiation
O1A01_RS01100	COG5662	AntiSigma factor
O1A01_RS01105	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
O1A01_RS01110	COG4856	YbbR-like protein
O1A01_RS01115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O1A01_RS01120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O1A01_RS01125	COG0402	S-adenosylhomocysteine deaminase activity
O1A01_RS01140	COG0318	PFAM AMP-dependent synthetase and ligase
O1A01_RS01150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O1A01_RS01155	COG0432	Pfam Uncharacterised protein family UPF0047
O1A01_RS01160	COG2002	toxin-antitoxin pair type II binding
O1A01_RS01170	COG1733	regulation of RNA biosynthetic process
O1A01_RS01175	COG2514	catechol 2,3-dioxygenase activity
O1A01_RS01185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O1A01_RS01190	COG3973	AAA domain
O1A01_RS01205	COG1937	Protein conserved in bacteria
O1A01_RS01210	COG2608	mercury ion transmembrane transporter activity
O1A01_RS01215	COG2217	Heavy metal translocating P-type atpase
O1A01_RS01225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1A01_RS01240	COG1181	Belongs to the D-alanine--D-alanine ligase family
O1A01_RS01245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O1A01_RS01250	COG0513	Belongs to the DEAD box helicase family
O1A01_RS01255	COG4294	response to UV
O1A01_RS01260	COG3402	PFAM membrane-flanked domain
O1A01_RS01265	COG3428	Bacterial PH domain
O1A01_RS01270	COG0705	Rhomboid family
O1A01_RS01275	COG0736	holo-[acyl-carrier-protein] synthase activity
O1A01_RS01280	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O1A01_RS01285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O1A01_RS01290	COG0864	Transcriptional regulator
O1A01_RS01295	COG2337	Toxic component of a toxin-antitoxin (TA) module
O1A01_RS01300	COG1366	Belongs to the anti-sigma-factor antagonist family
O1A01_RS01305	COG1366	Belongs to the anti-sigma-factor antagonist family
O1A01_RS01310	COG2172	sigma factor antagonist activity
O1A01_RS01315	COG2208	phosphoserine phosphatase activity
O1A01_RS01320	COG1366	Belongs to the anti-sigma-factor antagonist family
O1A01_RS01325	COG2172	sigma factor antagonist activity
O1A01_RS01330	COG1191	sigma factor activity
O1A01_RS01335	COG2208	phosphoserine phosphatase activity
O1A01_RS01340	COG2183	response to ionizing radiation
O1A01_RS01350	COG3091	SprT-like family
O1A01_RS01440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O1A01_RS01450	COG1214	PFAM Peptidase M22, glycoprotease
O1A01_RS01455	COG0456	acetyltransferase
O1A01_RS01460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O1A01_RS01465	COG0488	(ABC) transporter
O1A01_RS01470	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
O1A01_RS01475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O1A01_RS01480	COG0805	protein transport
O1A01_RS01490	COG1266	CAAX protease self-immunity
O1A01_RS01495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O1A01_RS01500	COG0459	protein refolding
O1A01_RS01525	COG0789	Transcriptional regulator
O1A01_RS01530	COG1266	CAAX protease self-immunity
O1A01_RS01540	COG1842	Phage shock protein A
O1A01_RS01545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O1A01_RS01550	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
O1A01_RS01555	COG4260	virion core protein, lumpy skin disease virus
O1A01_RS01560	COG1136	(ABC) transporter
O1A01_RS01565	COG0577	efflux transmembrane transporter activity
O1A01_RS01605	COG2304	oxidoreductase activity
O1A01_RS01655	COG0714	Associated with various cellular activities
O1A01_RS01660	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
O1A01_RS01665	COG1305	Transglutaminase-like
O1A01_RS01675	COG2252	PERMEase
O1A01_RS01740	COG0456	acetyltransferase
O1A01_RS01745	COG1304	FMN binding
O1A01_RS01750	COG2814	Major facilitator Superfamily
O1A01_RS01755	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O1A01_RS01760	COG1131	(ABC) transporter
O1A01_RS01780	COG1595	DNA-templated transcription, initiation
O1A01_RS01790	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
O1A01_RS01800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O1A01_RS01805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O1A01_RS01810	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O1A01_RS01815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O1A01_RS01820	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O1A01_RS01825	COG0047	phosphoribosylformylglycinamidine synthase activity
O1A01_RS01830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O1A01_RS01835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O1A01_RS01840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O1A01_RS01845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O1A01_RS01855	COG0151	Belongs to the GarS family
O1A01_RS01865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O1A01_RS01870	COG1470	cell adhesion involved in biofilm formation
O1A01_RS01875	COG4496	protein, YerC YecD
O1A01_RS01885	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
O1A01_RS01890	COG0210	DNA helicase
O1A01_RS01895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O1A01_RS01900	COG4851	CamS sex pheromone cAM373 precursor
O1A01_RS01905	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_RS01910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1A01_RS01915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1A01_RS01920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O1A01_RS01925	COG0154	amidase activity
O1A01_RS01935	COG1263	PTS System
O1A01_RS01935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_RS01935	COG2190	(PTS) system
O1A01_RS01940	COG1585	Membrane protein implicated in regulation of membrane protease activity
O1A01_RS01945	COG2268	Band 7 protein
O1A01_RS01950	COG1597	lipid kinase activity
O1A01_RS01960	COG1902	pentaerythritol trinitrate reductase activity
O1A01_RS01975	COG1733	regulation of RNA biosynthetic process
O1A01_RS01980	COG2514	catechol 2,3-dioxygenase activity
O1A01_RS01995	COG0395	ABC-type sugar transport system, permease component
O1A01_RS02005	COG3842	ATPase activity
O1A01_RS02010	COG1473	amidohydrolase
O1A01_RS02020	COG4948	Mandelate Racemase Muconate Lactonizing
O1A01_RS02025	COG3949	Membrane
O1A01_RS02030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O1A01_RS02035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O1A01_RS02040	COG4807	Protein conserved in bacteria
O1A01_RS02045	COG1595	DNA-templated transcription, initiation
O1A01_RS02070	COG0167	dihydroorotate dehydrogenase activity
O1A01_RS02075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
O1A01_RS02100	COG2258	MOSC domain
O1A01_RS02105	COG3344	reverse transcriptase
O1A01_RS02110	COG2239	Acts as a magnesium transporter
O1A01_RS02145	COG1193	negative regulation of DNA recombination
O1A01_RS02150	COG1272	protein, Hemolysin III
O1A01_RS02170	COG2723	6-phospho-beta-galactosidase activity
O1A01_RS02180	COG1175	transmembrane transport
O1A01_RS02185	COG0395	ABC-type sugar transport system, permease component
O1A01_RS02190	COG5578	integral membrane protein
O1A01_RS02210	COG1595	DNA-templated transcription, initiation
O1A01_RS02225	COG4521	taurine ABC transporter
O1A01_RS02230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1A01_RS02235	COG1116	anion transmembrane transporter activity
O1A01_RS02240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1A01_RS02245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1A01_RS02260	COG0514	ATP-dependent DNA helicase (RecQ)
O1A01_RS02265	COG0745	RESPONSE REGULATOR receiver
O1A01_RS02285	COG1785	Belongs to the alkaline phosphatase family
O1A01_RS02295	COG2801	Transposase and inactivated derivatives
O1A01_RS02315	COG2358	TRAP transporter, solute receptor (TAXI family
O1A01_RS02325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS02350	COG0861	Integral membrane protein TerC family
O1A01_RS02365	COG0346	lactoylglutathione lyase activity
O1A01_RS02370	COG1027	Aspartate ammonia-lyase
O1A01_RS02380	COG2076	Multidrug Resistance protein
O1A01_RS02390	COG1309	transcriptional regulator
O1A01_RS02440	COG1695	Transcriptional regulator
O1A01_RS02460	COG2409	Drug exporters of the RND superfamily
O1A01_RS02470	COG4895	conserved protein (DUF2196)
O1A01_RS02480	COG2502	aspartate--ammonia ligase
O1A01_RS02500	COG1408	metallophosphoesterase
O1A01_RS02505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O1A01_RS02505	COG4451	ribulose bisphosphate carboxylase, small
O1A01_RS02510	COG0745	RESPONSE REGULATOR receiver
O1A01_RS02515	COG5002	protein histidine kinase activity
O1A01_RS02520	COG1136	(ABC) transporter
O1A01_RS02530	COG4175	Glycine betaine
O1A01_RS02530	COG0517	IMP dehydrogenase activity
O1A01_RS02545	COG1737	Transcriptional regulator
O1A01_RS02550	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
O1A01_RS02555	COG2610	gluconate transmembrane transporter activity
O1A01_RS02560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1A01_RS02565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1A01_RS02570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O1A01_RS02575	COG1120	ATPase activity
O1A01_RS02580	COG0492	ferredoxin-NADP+ reductase activity
O1A01_RS02585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O1A01_RS02590	COG0390	transport system, permease component
O1A01_RS02605	COG1183	phosphatidylcholine synthase activity
O1A01_RS02615	COG1609	Transcriptional regulator
O1A01_RS02620	COG0166	Belongs to the GPI family
O1A01_RS02635	COG3173	Aminoglycoside phosphotransferase
O1A01_RS02640	COG0154	amidase activity
O1A01_RS02650	COG2368	4-hydroxyphenylacetate
O1A01_RS02665	COG0084	hydrolase, TatD family'
O1A01_RS02670	COG1132	(ABC) transporter
O1A01_RS02675	COG1132	(ABC) transporter
O1A01_RS02690	COG1115	amino acid carrier protein
O1A01_RS02695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1A01_RS02695	COG0723	plastoquinol--plastocyanin reductase activity
O1A01_RS02725	COG1309	transcriptional regulator
O1A01_RS02730	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O1A01_RS02740	COG0145	ligase activity
O1A01_RS02745	COG2124	cytochrome p450
O1A01_RS02755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1A01_RS02765	COG2244	polysaccharide biosynthetic process
O1A01_RS02775	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
O1A01_RS02790	COG1077	Cell shape determining protein MreB Mrl
O1A01_RS02810	COG2814	Major facilitator Superfamily
O1A01_RS02825	COG1115	amino acid carrier protein
O1A01_RS02840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS02850	COG1904	glucuronate isomerase
O1A01_RS02855	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O1A01_RS02860	COG1917	Cupin 2, conserved barrel domain protein
O1A01_RS02860	COG2207	Transcriptional regulator
O1A01_RS02870	COG0673	inositol 2-dehydrogenase activity
O1A01_RS02875	COG0673	inositol 2-dehydrogenase activity
O1A01_RS02885	COG2211	Major facilitator Superfamily
O1A01_RS02890	COG2211	Major facilitator Superfamily
O1A01_RS02895	COG1940	carbohydrate kinase activity
O1A01_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS02910	COG1606	tRNA processing
O1A01_RS02915	COG1070	Carbohydrate kinase
O1A01_RS02920	COG1691	(AIR) carboxylase
O1A01_RS02925	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
O1A01_RS02930	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
O1A01_RS02935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O1A01_RS02940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O1A01_RS02955	COG5002	protein histidine kinase activity
O1A01_RS02960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1A01_RS02995	COG1988	membrane-bound metal-dependent
O1A01_RS03005	COG4840	Belongs to the UPF0435 family
O1A01_RS03010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O1A01_RS03020	COG1295	ribonuclease BN
O1A01_RS03040	COG2217	Heavy metal translocating P-type atpase
O1A01_RS03045	COG0477	Major facilitator Superfamily
O1A01_RS03055	COG2364	Membrane
O1A01_RS03075	COG0535	radical SAM domain protein
O1A01_RS03155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
O1A01_RS03160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O1A01_RS03165	COG1104	cysteine desulfurase activity
O1A01_RS03170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS03175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS03175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS03180	COG2814	Major facilitator Superfamily
O1A01_RS03185	COG1196	nuclear chromosome segregation
O1A01_RS03230	COG0785	Cytochrome C biogenesis protein
O1A01_RS03235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_RS03240	COG0745	RESPONSE REGULATOR receiver
O1A01_RS03245	COG3850	Histidine kinase
O1A01_RS03245	COG5002	protein histidine kinase activity
O1A01_RS03250	COG0737	Belongs to the 5'-nucleotidase family
O1A01_RS03265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS03265	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS03270	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS03270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS03275	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_RS03280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS03280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS03285	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS03295	COG0288	reversible hydration of carbon dioxide
O1A01_RS03320	COG1937	Protein conserved in bacteria
O1A01_RS03325	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS03330	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_RS03340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS03345	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS03345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS03355	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_RS03360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS03360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS03365	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS03375	COG0662	Cupin 2, conserved barrel domain protein
O1A01_RS03380	COG0446	pyridine nucleotide-disulphide oxidoreductase
O1A01_RS03405	COG0653	protein targeting
O1A01_RS03415	COG0515	serine threonine protein kinase
O1A01_RS03480	COG3773	Cell wall hydrolase
O1A01_RS03495	COG0697	spore germination
O1A01_RS03515	COG0402	S-adenosylhomocysteine deaminase activity
O1A01_RS03535	COG1114	Component of the transport system for branched-chain amino acids
O1A01_RS03540	COG0659	secondary active sulfate transmembrane transporter activity
O1A01_RS03560	COG1063	alcohol dehydrogenase
O1A01_RS03590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O1A01_RS03625	COG1307	EDD domain protein, DegV family
O1A01_RS03650	COG0653	protein targeting
O1A01_RS03665	COG3290	protein histidine kinase activity
O1A01_RS03665	COG3829	transcription factor binding
O1A01_RS03675	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_RS03680	COG0564	pseudouridine synthase activity
O1A01_RS03690	COG1329	Transcriptional regulator
O1A01_RS03700	COG1595	DNA-templated transcription, initiation
O1A01_RS03715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O1A01_RS03720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O1A01_RS03735	COG0109	protoheme IX farnesyltransferase activity
O1A01_RS03740	COG1959	2 iron, 2 sulfur cluster binding
O1A01_RS03745	COG2910	NAD(P)H-binding
O1A01_RS03755	COG3481	metal-dependent phosphohydrolase, HD sub domain
O1A01_RS03765	COG2323	membrane
O1A01_RS03775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O1A01_RS03790	COG1136	(ABC) transporter
O1A01_RS03810	COG3620	sequence-specific DNA binding
O1A01_RS03830	COG2072	flavoprotein involved in K transport
O1A01_RS03835	COG2217	Heavy metal translocating P-type atpase
O1A01_RS03840	COG5001	Diguanylate cyclase
O1A01_RS03840	COG3300	MHYT domain
O1A01_RS03845	COG0697	spore germination
O1A01_RS03850	COG0814	amino acid
O1A01_RS03875	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O1A01_RS03880	COG0405	Gamma-glutamyltransferase
O1A01_RS03885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O1A01_RS03895	COG0640	Transcriptional regulator
O1A01_RS03900	COG3832	glyoxalase III activity
O1A01_RS03905	COG3706	GGDEF domain
O1A01_RS03915	COG2323	membrane
O1A01_RS03920	COG0038	chloride channel
O1A01_RS03925	COG0569	domain protein
O1A01_RS03930	COG4555	ABC transporter
O1A01_RS03940	COG0656	L-ascorbic acid biosynthetic process
O1A01_RS03945	COG1131	(ABC) transporter
O1A01_RS03950	COG0842	Transport permease protein
O1A01_RS03950	COG1511	domain protein
O1A01_RS03960	COG1363	Peptidase, m42
O1A01_RS03990	COG0673	inositol 2-dehydrogenase activity
O1A01_RS03995	COG0673	inositol 2-dehydrogenase activity
O1A01_RS04020	COG2233	PERMEase
O1A01_RS04035	COG0840	transmembrane signaling receptor activity
O1A01_RS04040	COG0460	homoserine dehydrogenase
O1A01_RS04045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O1A01_RS04050	COG0083	homoserine kinase activity
O1A01_RS04055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O1A01_RS04060	COG0129	dihydroxy-acid dehydratase activity
O1A01_RS04065	COG0028	Belongs to the TPP enzyme family
O1A01_RS04070	COG0440	acetolactate synthase activity
O1A01_RS04075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O1A01_RS04080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O1A01_RS04090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O1A01_RS04095	COG0066	3-isopropylmalate dehydratase activity
O1A01_RS04100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O1A01_RS04105	COG1404	Belongs to the peptidase S8 family
O1A01_RS04110	COG2208	phosphoserine phosphatase activity
O1A01_RS04115	COG0596	Alpha beta hydrolase
O1A01_RS04145	COG0686	Belongs to the AlaDH PNT family
O1A01_RS04150	COG2508	Transcriptional regulator
O1A01_RS04150	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O1A01_RS04160	COG2409	Drug exporters of the RND superfamily
O1A01_RS04165	COG2814	Major facilitator Superfamily
O1A01_RS04175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O1A01_RS04185	COG1595	DNA-templated transcription, initiation
O1A01_RS04190	COG1757	Na H antiporter
O1A01_RS04195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O1A01_RS04210	COG3639	organic phosphonate transmembrane transporter activity
O1A01_RS04230	COG0395	ABC-type sugar transport system, permease component
O1A01_RS04235	COG1653	transport
O1A01_RS04245	COG0733	neurotransmitter:sodium symporter activity
O1A01_RS04275	COG5577	PFAM Coat F domain
O1A01_RS04280	COG1063	alcohol dehydrogenase
O1A01_RS04290	COG0427	acetyl-CoA hydrolase
O1A01_RS04295	COG1619	proteins homologs of microcin C7 resistance protein MccF
O1A01_RS04300	COG1834	amidinotransferase
O1A01_RS04305	COG2205	protein histidine kinase activity
O1A01_RS04310	COG2211	Major facilitator Superfamily
O1A01_RS04315	COG2329	Antibiotic biosynthesis monooxygenase
O1A01_RS04325	COG1280	lysine exporter protein (LysE YggA)
O1A01_RS04365	COG0534	Mate efflux family protein
O1A01_RS04370	COG1309	transcriptional regulator
O1A01_RS04375	COG2814	Major facilitator Superfamily
O1A01_RS04405	COG3279	Response regulator of the LytR AlgR family
O1A01_RS04410	COG4555	ABC transporter
O1A01_RS04415	COG1668	transmembrane transport
O1A01_RS04425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O1A01_RS04435	COG1960	acyl-CoA dehydrogenase activity
O1A01_RS04445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1A01_RS04450	COG1846	Transcriptional regulator
O1A01_RS04455	COG2814	Major facilitator Superfamily
O1A01_RS04460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O1A01_RS04480	COG1757	Na H antiporter
O1A01_RS04505	COG1228	amidohydrolase
O1A01_RS04510	COG1090	epimerase
O1A01_RS04520	COG4221	oxidoreductase activity
O1A01_RS04545	COG1988	membrane-bound metal-dependent
O1A01_RS04550	COG1194	a g-specific adenine glycosylase
O1A01_RS04570	COG3557	Belongs to the UPF0374 family
O1A01_RS04575	COG1132	(ABC) transporter
O1A01_RS04580	COG4129	membrane
O1A01_RS04585	COG0069	glutamate synthase activity
O1A01_RS04585	COG0067	glutamate synthase
O1A01_RS04585	COG0070	glutamate synthase
O1A01_RS04605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O1A01_RS04610	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O1A01_RS04615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O1A01_RS04620	COG2096	Adenosyltransferase
O1A01_RS04625	COG0735	belongs to the Fur family
O1A01_RS04740	COG3382	B3 4 domain protein
O1A01_RS04755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O1A01_RS04760	COG2766	serine protein kinase
O1A01_RS04765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1A01_RS04780	COG0747	negative chemotaxis
O1A01_RS04790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1A01_RS04795	COG0601	transmembrane transport
O1A01_RS04800	COG0444	Belongs to the ABC transporter superfamily
O1A01_RS04805	COG4608	Belongs to the ABC transporter superfamily
O1A01_RS04810	COG0697	spore germination
O1A01_RS04845	COG0372	Belongs to the citrate synthase family
O1A01_RS04850	COG0583	DNA-binding transcription factor activity
O1A01_RS04865	COG0708	Exodeoxyribonuclease III
O1A01_RS04870	COG4607	ABC-type enterochelin transport system periplasmic component
O1A01_RS04880	COG4667	esterase of the alpha-beta hydrolase superfamily
O1A01_RS04885	COG1164	Oligoendopeptidase f
O1A01_RS04890	COG4191	Histidine kinase
O1A01_RS04895	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1A01_RS04900	COG4605	iron ion homeostasis
O1A01_RS04905	COG4604	ABC transporter, ATP-binding protein
O1A01_RS04910	COG4607	ABC-type enterochelin transport system periplasmic component
O1A01_RS04915	COG4536	flavin adenine dinucleotide binding
O1A01_RS04925	COG0840	transmembrane signaling receptor activity
O1A01_RS04935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O1A01_RS04950	COG1968	undecaprenyl-diphosphatase activity
O1A01_RS04955	COG2205	protein histidine kinase activity
O1A01_RS04965	COG0789	Transcriptional regulator
O1A01_RS04985	COG0564	pseudouridine synthase activity
O1A01_RS05000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O1A01_RS05015	COG1228	amidohydrolase
O1A01_RS05030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1A01_RS05030	COG3153	acetyltransferase
O1A01_RS05035	COG0791	NLP P60 protein
O1A01_RS05035	COG1388	LysM domain
O1A01_RS05050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O1A01_RS05055	COG2203	Gaf domain
O1A01_RS05055	COG4585	Histidine kinase
O1A01_RS05060	COG2197	response regulator
O1A01_RS05065	COG0431	NADPH-dependent FMN reductase
O1A01_RS05085	COG2239	Acts as a magnesium transporter
O1A01_RS05090	COG0730	response to heat
O1A01_RS05095	COG2719	SpoVR family
O1A01_RS05130	COG0640	Transcriptional regulator
O1A01_RS05135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O1A01_RS05140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O1A01_RS05145	COG0154	amidase activity
O1A01_RS05165	COG1794	racemase activity, acting on amino acids and derivatives
O1A01_RS05170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1A01_RS05175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O1A01_RS05185	COG0398	Pfam SNARE associated Golgi protein
O1A01_RS05200	COG1131	(ABC) transporter
O1A01_RS05215	COG0582	viral genome integration into host DNA
O1A01_RS05225	COG0534	Mate efflux family protein
O1A01_RS05230	COG2814	Major facilitator Superfamily
O1A01_RS05240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O1A01_RS05255	COG0521	Mo-molybdopterin cofactor biosynthetic process
O1A01_RS05260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O1A01_RS05275	COG0303	'Molybdopterin
O1A01_RS05280	COG1763	Mo-molybdopterin cofactor biosynthetic process
O1A01_RS05285	COG0314	molybdopterin synthase activity
O1A01_RS05290	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O1A01_RS05315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1A01_RS05320	COG0746	molybdenum cofactor guanylyltransferase activity
O1A01_RS05325	COG0535	radical SAM domain protein
O1A01_RS05330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1A01_RS05335	COG0489	protein tyrosine kinase activity
O1A01_RS05345	COG0243	molybdopterin cofactor binding
O1A01_RS05350	COG0437	4 iron, 4 sulfur cluster binding
O1A01_RS05365	COG1686	Belongs to the peptidase S11 family
O1A01_RS05380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O1A01_RS05415	COG1078	dGTPase activity
O1A01_RS05420	COG0586	Pfam SNARE associated Golgi protein
O1A01_RS05430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O1A01_RS05435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O1A01_RS05445	COG1301	dicarboxylic acid transport
O1A01_RS05450	COG1970	mechanosensitive ion channel activity
O1A01_RS05460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1A01_RS05470	COG0393	Putative heavy-metal-binding
O1A01_RS05475	COG3773	Cell wall hydrolase
O1A01_RS05490	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O1A01_RS05500	COG1122	ATPase activity
O1A01_RS05510	COG0352	thiamine-phosphate diphosphorylase activity
O1A01_RS05515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1A01_RS05520	COG2104	thiamine diphosphate biosynthetic process
O1A01_RS05525	COG2022	thiamine diphosphate biosynthetic process
O1A01_RS05530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O1A01_RS05535	COG0351	phosphomethylpyrimidine kinase
O1A01_RS05545	COG4989	oxidoreductase activity
O1A01_RS05560	COG1607	acyl-coa hydrolase
O1A01_RS05575	COG1132	(ABC) transporter
O1A01_RS05580	COG1132	(ABC) transporter
O1A01_RS05585	COG1253	flavin adenine dinucleotide binding
O1A01_RS05600	COG3842	ATPase activity
O1A01_RS05605	COG2508	Transcriptional regulator
O1A01_RS05620	COG0189	ligase activity
O1A01_RS05625	COG0189	ligase activity
O1A01_RS05630	COG0189	ligase activity
O1A01_RS05635	COG0189	ligase activity
O1A01_RS05645	COG3679	Belongs to the UPF0342 family
O1A01_RS05650	COG0561	phosphatase activity
O1A01_RS05655	COG1131	(ABC) transporter
O1A01_RS05660	COG0842	Transport permease protein
O1A01_RS05665	COG4585	Histidine kinase
O1A01_RS05670	COG2197	response regulator
O1A01_RS05675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O1A01_RS05680	COG4412	M6 family metalloprotease domain protein
O1A01_RS05680	COG1404	Belongs to the peptidase S8 family
O1A01_RS05700	COG0681	Belongs to the peptidase S26 family
O1A01_RS05705	COG1024	Enoyl-CoA hydratase
O1A01_RS05715	COG0420	3'-5' exonuclease activity
O1A01_RS05720	COG4717	serine-type aminopeptidase activity
O1A01_RS05725	COG3481	metal-dependent phosphohydrolase, HD sub domain
O1A01_RS05735	COG2233	PERMEase
O1A01_RS05740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O1A01_RS05770	COG1846	Transcriptional regulator
O1A01_RS05790	COG0537	adenosine 5'-monophosphoramidase activity
O1A01_RS05795	COG1131	(ABC) transporter
O1A01_RS05800	COG4473	ABC transporter
O1A01_RS05810	COG1473	amidohydrolase
O1A01_RS05825	COG4585	Histidine kinase
O1A01_RS05830	COG2197	response regulator
O1A01_RS05835	COG2329	Antibiotic biosynthesis monooxygenase
O1A01_RS05840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1A01_RS05845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O1A01_RS05850	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O1A01_RS05855	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
O1A01_RS05865	COG1609	Transcriptional regulator
O1A01_RS05875	COG1234	tRNA 3'-trailer cleavage
O1A01_RS05880	COG0095	Lipoate-protein ligase
O1A01_RS05885	COG0318	PFAM AMP-dependent synthetase and ligase
O1A01_RS05890	COG1024	Enoyl-CoA hydratase
O1A01_RS05895	COG2199	diguanylate cyclase activity
O1A01_RS05895	COG2200	EAL domain
O1A01_RS05895	COG2202	Pas domain
O1A01_RS05905	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
O1A01_RS05915	COG1999	signal sequence binding
O1A01_RS05920	COG0501	Belongs to the peptidase M48B family
O1A01_RS05950	COG0398	Pfam SNARE associated Golgi protein
O1A01_RS05960	COG0183	Belongs to the thiolase family
O1A01_RS05975	COG0411	ABC transporter
O1A01_RS05985	COG0559	Belongs to the binding-protein-dependent transport system permease family
O1A01_RS06000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1A01_RS06010	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS06015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O1A01_RS06020	COG0318	PFAM AMP-dependent synthetase and ligase
O1A01_RS06030	COG0706	membrane insertase activity
O1A01_RS06035	COG2814	Major facilitator Superfamily
O1A01_RS06040	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
O1A01_RS06045	COG1074	ATP-dependent DNA helicase activity
O1A01_RS06050	COG0420	3'-5' exonuclease activity
O1A01_RS06055	COG0419	ATPase involved in DNA repair
O1A01_RS06060	COG1403	HNH endonuclease
O1A01_RS06100	COG2311	Membrane
O1A01_RS06110	COG0179	Fumarylacetoacetate (FAA) hydrolase
O1A01_RS06115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1A01_RS06125	COG5001	Diguanylate cyclase
O1A01_RS06125	COG3300	MHYT domain
O1A01_RS06135	COG0367	asparagine synthase
O1A01_RS06140	COG0004	ammonium transporteR
O1A01_RS06150	COG0534	Mate efflux family protein
O1A01_RS06155	COG1917	Cupin 2, conserved barrel domain protein
O1A01_RS06155	COG2207	Transcriptional regulator
O1A01_RS06165	COG2182	Extracellular solute-binding protein
O1A01_RS06170	COG1175	transmembrane transport
O1A01_RS06175	COG3833	ABC-type maltose transport systems, permease component
O1A01_RS06180	COG0366	Alpha amylase catalytic
O1A01_RS06180	COG1874	Beta-galactosidase
O1A01_RS06185	COG1609	Transcriptional regulator
O1A01_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS06200	COG1666	GTP binding
O1A01_RS06205	COG2996	Protein conserved in bacteria
O1A01_RS06215	COG1307	EDD domain protein, DegV family
O1A01_RS06220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O1A01_RS06240	COG0561	phosphatase activity
O1A01_RS06245	COG1073	alpha beta
O1A01_RS06250	COG2151	metal-sulfur cluster biosynthetic enzyme
O1A01_RS06260	COG0542	response to heat
O1A01_RS06275	COG2267	carboxylic ester hydrolase activity
O1A01_RS06285	COG1744	ABC transporter substrate-binding protein PnrA-like
O1A01_RS06300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1A01_RS06305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O1A01_RS06310	COG5504	Zn-dependent protease
O1A01_RS06315	COG0444	Belongs to the ABC transporter superfamily
O1A01_RS06320	COG4608	Belongs to the ABC transporter superfamily
O1A01_RS06330	COG0601	transmembrane transport
O1A01_RS06335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1A01_RS06350	COG0180	Tryptophanyl-tRNA synthetase
O1A01_RS06365	COG1473	amidohydrolase
O1A01_RS06375	COG4166	transmembrane transport
O1A01_RS06380	COG0601	transmembrane transport
O1A01_RS06385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1A01_RS06390	COG0444	Belongs to the ABC transporter superfamily
O1A01_RS06395	COG4608	Belongs to the ABC transporter superfamily
O1A01_RS06410	COG0456	acetyltransferase
O1A01_RS06430	COG1393	Belongs to the ArsC family
O1A01_RS06445	COG4862	establishment of competence for transformation
O1A01_RS06450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O1A01_RS06460	COG1164	Oligoendopeptidase f
O1A01_RS06475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O1A01_RS06480	COG2346	COG2346, Truncated hemoglobins
O1A01_RS06485	COG0741	lytic transglycosylase activity
O1A01_RS06490	COG4116	CYTH
O1A01_RS06500	COG2357	RelA SpoT domain protein
O1A01_RS06510	COG0564	pseudouridine synthase activity
O1A01_RS06515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O1A01_RS06520	COG0772	Belongs to the SEDS family
O1A01_RS06525	COG0475	glutathione-regulated potassium exporter activity
O1A01_RS06525	COG0589	response to stress
O1A01_RS06575	COG0438	transferase activity, transferring glycosyl groups
O1A01_RS06625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O1A01_RS06630	COG0463	Glycosyl transferase, family 2
O1A01_RS06680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1A01_RS06695	COG2323	membrane
O1A01_RS06735	COG0210	DNA helicase
O1A01_RS06745	COG2323	membrane
O1A01_RS06765	COG2153	protein acetylation
O1A01_RS06770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
O1A01_RS06775	COG2382	esterase
O1A01_RS06795	COG1999	signal sequence binding
O1A01_RS06805	COG1418	mRNA catabolic process
O1A01_RS06825	COG0582	viral genome integration into host DNA
O1A01_RS07120	COG0582	viral genome integration into host DNA
O1A01_RS07230	COG1484	DNA-dependent DNA replication
O1A01_RS07250	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
O1A01_RS07275	COG2201	protein-glutamate methylesterase activity
O1A01_RS07320	COG3677	Transposase
O1A01_RS07340	COG3728	DNA packaging
O1A01_RS07340	COG5484	DNA packaging
O1A01_RS07525	COG2720	vancomycin resistance protein
O1A01_RS07530	COG1802	Transcriptional regulator
O1A01_RS07540	COG0601	transmembrane transport
O1A01_RS07545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1A01_RS07555	COG1124	(ABC) transporter
O1A01_RS07560	COG1114	Component of the transport system for branched-chain amino acids
O1A01_RS07590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1A01_RS07600	COG3620	sequence-specific DNA binding
O1A01_RS07620	COG2188	Transcriptional regulator
O1A01_RS07625	COG1263	PTS System
O1A01_RS07625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_RS07630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1A01_RS07635	COG4844	belongs to the
O1A01_RS07665	COG2270	Major facilitator Superfamily
O1A01_RS07680	COG0693	protein deglycase activity
O1A01_RS07720	COG5002	protein histidine kinase activity
O1A01_RS07740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1A01_RS07745	COG2146	nitrite reductase [NAD(P)H] activity
O1A01_RS07750	COG1587	Uroporphyrinogen-III synthase
O1A01_RS07750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O1A01_RS07755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
O1A01_RS07760	COG1177	transmembrane transport
O1A01_RS07765	COG1176	ABC-type spermidine putrescine transport system, permease component I
O1A01_RS07770	COG3842	ATPase activity
O1A01_RS07775	COG1132	(ABC) transporter
O1A01_RS07800	COG0789	Transcriptional regulator
O1A01_RS07810	COG2112	serine threonine protein kinase
O1A01_RS07815	COG0438	transferase activity, transferring glycosyl groups
O1A01_RS07825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1A01_RS07830	COG4191	Histidine kinase
O1A01_RS07835	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
O1A01_RS07835	COG2105	PFAM AIG2 family protein
O1A01_RS07845	COG1979	alcohol dehydrogenase
O1A01_RS07850	COG2304	oxidoreductase activity
O1A01_RS07855	COG4129	membrane
O1A01_RS07940	COG2814	Major facilitator Superfamily
O1A01_RS07945	COG1595	DNA-templated transcription, initiation
O1A01_RS07965	COG4533	DNA binding
O1A01_RS07975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O1A01_RS07980	COG5278	phosphoserine phosphatase activity
O1A01_RS07980	COG0840	transmembrane signaling receptor activity
O1A01_RS07985	COG3340	Belongs to the peptidase S51 family
O1A01_RS07990	COG2207	Transcriptional regulator
O1A01_RS07995	COG0789	Transcriptional regulator
O1A01_RS08000	COG2365	Tyrosine phosphatase family
O1A01_RS08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1A01_RS08010	COG0765	amino acid transport
O1A01_RS08015	COG1126	abc transporter atp-binding protein
O1A01_RS08030	COG1132	(ABC) transporter
O1A01_RS08040	COG0697	spore germination
O1A01_RS08045	COG0628	permease
O1A01_RS08080	COG0579	oxidoreductase
O1A01_RS08090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O1A01_RS08100	COG1649	PFAM Uncharacterised BCR, COG1649
O1A01_RS08105	COG3773	Cell wall hydrolase
O1A01_RS08120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1A01_RS08140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O1A01_RS08145	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_RS08160	COG0823	Involved in the tonB-independent uptake of proteins
O1A01_RS08160	COG4946	Tricorn protease homolog
O1A01_RS08160	COG1506	peptidase
O1A01_RS08165	COG1609	Transcriptional regulator
O1A01_RS08170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_RS08170	COG1263	PTS System
O1A01_RS08175	COG1621	beta-fructofuranosidase activity
O1A01_RS08180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1A01_RS08185	COG0702	epimerase
O1A01_RS08195	COG0753	catalase activity
O1A01_RS08205	COG1396	sequence-specific DNA binding
O1A01_RS08215	COG0657	acetylesterase activity
O1A01_RS08220	COG0561	phosphatase activity
O1A01_RS08225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O1A01_RS08230	COG0583	DNA-binding transcription factor activity
O1A01_RS08235	COG1595	DNA-templated transcription, initiation
O1A01_RS08240	COG1316	TRANSCRIPTIONal
O1A01_RS08245	COG0860	N-Acetylmuramoyl-L-alanine amidase
O1A01_RS08250	COG1595	DNA-templated transcription, initiation
O1A01_RS08275	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O1A01_RS08290	COG0405	Gamma-glutamyltransferase
O1A01_RS08315	COG1476	TRANSCRIPTIONal
O1A01_RS08345	COG3300	MHYT domain
O1A01_RS08345	COG5001	Diguanylate cyclase
O1A01_RS08355	COG1595	DNA-templated transcription, initiation
O1A01_RS08370	COG0450	alkyl hydroperoxide reductase
O1A01_RS08375	COG3634	alkyl hydroperoxide reductase activity
O1A01_RS08410	COG5578	integral membrane protein
O1A01_RS08420	COG3458	cephalosporin-C deacetylase activity
O1A01_RS08425	COG1737	Transcriptional regulator
O1A01_RS08435	COG4209	transmembrane transport
O1A01_RS08440	COG0395	ABC-type sugar transport system, permease component
O1A01_RS08445	COG1653	transport
O1A01_RS08460	COG1472	Belongs to the glycosyl hydrolase 3 family
O1A01_RS08480	COG4145	pantothenate transmembrane transporter activity
O1A01_RS08485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_RS08490	COG0473	3-isopropylmalate dehydrogenase activity
O1A01_RS08500	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_RS08505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O1A01_RS08510	COG1522	sequence-specific DNA binding
O1A01_RS08520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O1A01_RS08525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O1A01_RS08530	COG0745	RESPONSE REGULATOR receiver
O1A01_RS08535	COG3850	Histidine kinase
O1A01_RS08535	COG5002	protein histidine kinase activity
O1A01_RS08540	COG1136	(ABC) transporter
O1A01_RS08550	COG0745	RESPONSE REGULATOR receiver
O1A01_RS08555	COG2205	protein histidine kinase activity
O1A01_RS08560	COG1136	(ABC) transporter
O1A01_RS08565	COG0577	efflux transmembrane transporter activity
O1A01_RS08580	COG1757	Na H antiporter
O1A01_RS08585	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O1A01_RS08590	COG1126	abc transporter atp-binding protein
O1A01_RS08595	COG0765	amino acid transport
O1A01_RS08600	COG0765	amino acid transport
O1A01_RS08605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1A01_RS08610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O1A01_RS08625	COG2030	dehydratase
O1A01_RS08630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1A01_RS08680	COG0446	pyridine nucleotide-disulphide oxidoreductase
O1A01_RS08705	COG1136	(ABC) transporter
O1A01_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS08735	COG0668	transmembrane transport
O1A01_RS08740	COG2234	aminopeptidase activity
O1A01_RS08745	COG0477	Major facilitator Superfamily
O1A01_RS08780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O1A01_RS08785	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1A01_RS08795	COG4948	Mandelate Racemase Muconate Lactonizing
O1A01_RS08800	COG1288	antiporter activity
O1A01_RS08810	COG1473	amidohydrolase
O1A01_RS08825	COG1388	LysM domain
O1A01_RS08825	COG0791	NLP P60 protein
O1A01_RS08830	COG0745	RESPONSE REGULATOR receiver
O1A01_RS08835	COG3850	Histidine kinase
O1A01_RS08835	COG5002	protein histidine kinase activity
O1A01_RS08845	COG0577	efflux transmembrane transporter activity
O1A01_RS08850	COG1136	(ABC) transporter
O1A01_RS08855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_RS08865	COG0737	Belongs to the 5'-nucleotidase family
O1A01_RS08870	COG1191	sigma factor activity
O1A01_RS08890	COG1584	GPR1 FUN34 yaaH family protein
O1A01_RS08895	COG1657	PFAM Prenyltransferase squalene oxidase
O1A01_RS08920	COG2226	methyltransferase
O1A01_RS08930	COG2267	carboxylic ester hydrolase activity
O1A01_RS08950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O1A01_RS08960	COG1476	TRANSCRIPTIONal
O1A01_RS08965	COG2207	Transcriptional regulator
O1A01_RS08970	COG1472	Belongs to the glycosyl hydrolase 3 family
O1A01_RS08990	COG3314	Sporulation integral membrane protein YlbJ
O1A01_RS09000	COG0702	epimerase
O1A01_RS09015	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
O1A01_RS09035	COG1115	amino acid carrier protein
O1A01_RS09040	COG1215	transferase activity, transferring glycosyl groups
O1A01_RS09045	COG1414	Transcriptional regulator
O1A01_RS09050	COG0531	amino acid
O1A01_RS09060	COG1388	LysM domain
O1A01_RS09060	COG0791	NLP P60 protein
O1A01_RS09125	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
O1A01_RS09140	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O1A01_RS09145	COG0456	acetyltransferase
O1A01_RS09160	COG0653	protein targeting
O1A01_RS09170	COG0745	RESPONSE REGULATOR receiver
O1A01_RS09185	COG2205	protein histidine kinase activity
O1A01_RS09200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1A01_RS09210	COG2814	Major facilitator Superfamily
O1A01_RS09215	COG0640	Transcriptional regulator
O1A01_RS09305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1A01_RS09325	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS09335	COG4145	pantothenate transmembrane transporter activity
O1A01_RS09390	COG2197	response regulator
O1A01_RS09450	COG2200	EAL domain
O1A01_RS09455	COG3119	arylsulfatase activity
O1A01_RS09465	COG2746	aminoglycoside 3-N-acetyltransferase activity
O1A01_RS09470	COG0493	'glutamate synthase
O1A01_RS09525	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS09540	COG0322	excinuclease ABC activity
O1A01_RS09550	COG0210	DNA helicase
O1A01_RS09640	COG1061	Type III restriction enzyme res subunit
O1A01_RS09650	COG0210	DNA helicase
O1A01_RS09765	COG1401	restriction endodeoxyribonuclease activity
O1A01_RS09775	COG0583	DNA-binding transcription factor activity
O1A01_RS09780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
O1A01_RS09795	COG0456	acetyltransferase
O1A01_RS09805	COG1595	DNA-templated transcription, initiation
O1A01_RS09825	COG1192	Involved in chromosome partitioning
O1A01_RS09855	COG1595	DNA-templated transcription, initiation
O1A01_RS09870	COG5646	InterPro IPR014922
O1A01_RS09875	COG2222	sugar isomerase
O1A01_RS09880	COG1653	transport
O1A01_RS09885	COG1175	transmembrane transport
O1A01_RS09890	COG0395	ABC-type sugar transport system, permease component
O1A01_RS09895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1A01_RS09900	COG2188	Transcriptional regulator
O1A01_RS09905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O1A01_RS09925	COG1404	Belongs to the peptidase S8 family
O1A01_RS09940	COG1595	DNA-templated transcription, initiation
O1A01_RS09955	COG1136	(ABC) transporter
O1A01_RS09975	COG0110	maltose O-acetyltransferase activity
O1A01_RS09985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
O1A01_RS10025	COG0110	maltose O-acetyltransferase activity
O1A01_RS10060	COG2247	cell wall binding repeat
O1A01_RS10060	COG2385	sporulation resulting in formation of a cellular spore
O1A01_RS10085	COG0477	Major facilitator Superfamily
O1A01_RS10180	COG5504	Zn-dependent protease
O1A01_RS10210	COG1214	PFAM Peptidase M22, glycoprotease
O1A01_RS10210	COG0456	acetyltransferase
O1A01_RS10255	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
O1A01_RS10260	COG3844	kynureninase activity
O1A01_RS10265	COG1309	transcriptional regulator
O1A01_RS10275	COG0494	nUDIX hydrolase
O1A01_RS10280	COG0494	nUDIX hydrolase
O1A01_RS10295	COG0500	methyltransferase
O1A01_RS10295	COG3615	Tellurite resistance protein tehB
O1A01_RS10300	COG0681	Belongs to the peptidase S26 family
O1A01_RS10320	COG0154	amidase activity
O1A01_RS10465	COG0488	(ABC) transporter
O1A01_RS10470	COG2746	aminoglycoside 3-N-acetyltransferase activity
O1A01_RS10485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O1A01_RS10520	COG1846	Transcriptional regulator
O1A01_RS10525	COG0456	acetyltransferase
O1A01_RS10530	COG2808	Putative FMN-binding domain
O1A01_RS10570	COG0202	RNA polymerase activity
O1A01_RS10610	COG0656	L-ascorbic acid biosynthetic process
O1A01_RS10630	COG1595	DNA-templated transcription, initiation
O1A01_RS10655	COG1063	alcohol dehydrogenase
O1A01_RS10690	COG1164	Oligoendopeptidase f
O1A01_RS10700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O1A01_RS10710	COG1595	DNA-templated transcription, initiation
O1A01_RS10725	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O1A01_RS10735	COG0789	Transcriptional regulator
O1A01_RS10735	COG4978	Transcriptional regulator
O1A01_RS10740	COG2814	Major facilitator Superfamily
O1A01_RS10800	COG1309	transcriptional regulator
O1A01_RS10820	COG0753	catalase activity
O1A01_RS10825	COG0515	serine threonine protein kinase
O1A01_RS10825	COG1357	PFAM Pentapeptide repeats (8 copies)
O1A01_RS10845	COG2323	membrane
O1A01_RS10850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1A01_RS10865	COG1595	DNA-templated transcription, initiation
O1A01_RS10875	COG2226	methyltransferase
O1A01_RS10890	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_RS10890	COG2213	PTS system mannitol-specific
O1A01_RS10895	COG3711	transcriptional antiterminator
O1A01_RS10940	COG2135	peptidase activity
O1A01_RS10965	COG0778	Nitroreductase
O1A01_RS10970	COG0346	lactoylglutathione lyase activity
O1A01_RS10975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1A01_RS10980	COG0346	lactoylglutathione lyase activity
O1A01_RS10985	COG0400	carboxylic ester hydrolase activity
O1A01_RS10990	COG2259	Doxx family
O1A01_RS11000	COG0662	Cupin 2, conserved barrel domain protein
O1A01_RS11005	COG0697	spore germination
O1A01_RS11010	COG1522	sequence-specific DNA binding
O1A01_RS11030	COG4149	molybdate abc transporter
O1A01_RS11035	COG1846	Transcriptional regulator
O1A01_RS11040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O1A01_RS11055	COG1714	RDD family
O1A01_RS11070	COG0596	Alpha beta hydrolase
O1A01_RS11080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O1A01_RS11100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O1A01_RS11120	COG1595	DNA-templated transcription, initiation
O1A01_RS11150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1A01_RS11160	COG4682	membrane
O1A01_RS11170	COG0697	spore germination
O1A01_RS11220	COG1051	belongs to the nudix hydrolase family
O1A01_RS11270	COG0596	Alpha beta hydrolase
O1A01_RS11275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O1A01_RS11295	COG1131	(ABC) transporter
O1A01_RS11310	COG0714	Associated with various cellular activities
O1A01_RS11330	COG2364	Membrane
O1A01_RS11340	COG0114	fumarate hydratase activity
O1A01_RS11360	COG0435	Glutathione S-transferase
O1A01_RS11370	COG0300	oxidoreductase activity
O1A01_RS11375	COG3118	belongs to the thioredoxin family
O1A01_RS11390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_RS11390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_RS11400	COG3012	SEC-C Motif Domain Protein
O1A01_RS11400	COG1405	negative regulation of cell septum assembly
O1A01_RS11405	COG0436	Aminotransferase
O1A01_RS11410	COG2329	Antibiotic biosynthesis monooxygenase
O1A01_RS11420	COG1929	Belongs to the glycerate kinase type-1 family
O1A01_RS11435	COG1271	oxidase subunit
O1A01_RS11440	COG1294	oxidase, subunit
O1A01_RS11445	COG4988	ABC transporter
O1A01_RS11450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O1A01_RS11455	COG2764	glyoxalase bleomycin resistance protein dioxygenase
O1A01_RS11470	COG1309	transcriptional regulator
O1A01_RS11475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1A01_RS11480	COG1278	Cold shock
O1A01_RS11495	COG2188	Transcriptional regulator
O1A01_RS11500	COG1131	(ABC) transporter
O1A01_RS11505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_RS11530	COG1363	Peptidase, m42
O1A01_RS11535	COG1533	DNA photolyase activity
O1A01_RS11550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O1A01_RS11555	COG2224	Isocitrate lyase
O1A01_RS11570	COG2814	Major facilitator Superfamily
O1A01_RS11585	COG1388	LysM domain
O1A01_RS11585	COG3584	3D domain protein
O1A01_RS11625	COG0668	transmembrane transport
O1A01_RS11635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1A01_RS11650	COG3285	dna ligase
O1A01_RS11650	COG1793	dna ligase
O1A01_RS11655	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O1A01_RS11670	COG1191	sigma factor activity
O1A01_RS11685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O1A01_RS11690	COG2814	Major facilitator Superfamily
O1A01_RS11715	COG5002	protein histidine kinase activity
O1A01_RS11720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O1A01_RS11725	COG0640	Transcriptional regulator
O1A01_RS11730	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
O1A01_RS11735	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
O1A01_RS11740	COG1278	Cold shock
O1A01_RS11745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1A01_RS11750	COG0436	Aminotransferase
O1A01_RS11755	COG1850	ribulose-bisphosphate carboxylase activity
O1A01_RS11760	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
O1A01_RS11765	COG0235	Class ii aldolase
O1A01_RS11770	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
O1A01_RS11780	COG2861	carbohydrate metabolic process
O1A01_RS11800	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
O1A01_RS11805	COG3639	organic phosphonate transmembrane transporter activity
O1A01_RS11810	COG3639	organic phosphonate transmembrane transporter activity
O1A01_RS11815	COG0737	Belongs to the 5'-nucleotidase family
O1A01_RS11820	COG1846	Transcriptional regulator
O1A01_RS11830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O1A01_RS11845	COG3949	Membrane
O1A01_RS11850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O1A01_RS11870	COG0720	synthase
O1A01_RS11880	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O1A01_RS11890	COG4873	Protein conserved in bacteria
O1A01_RS11940	COG1725	Transcriptional regulator
O1A01_RS11945	COG1131	(ABC) transporter
O1A01_RS11960	COG1131	(ABC) transporter
O1A01_RS11965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O1A01_RS11970	COG1136	(ABC) transporter
O1A01_RS11975	COG0577	efflux transmembrane transporter activity
O1A01_RS11980	COG0726	polysaccharide deacetylase
O1A01_RS12000	COG0714	Associated with various cellular activities
O1A01_RS12035	COG3546	catalase activity
O1A01_RS12040	COG1388	LysM domain
O1A01_RS12040	COG0791	NLP P60 protein
O1A01_RS12075	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS12090	COG2986	histidine ammonia-lyase
O1A01_RS12095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O1A01_RS12105	COG0010	Belongs to the arginase family
O1A01_RS12110	COG3859	Proton-coupled thiamine transporter YuaJ
O1A01_RS12115	COG2084	Dehydrogenase
O1A01_RS12120	COG4191	Histidine kinase
O1A01_RS12125	COG0733	neurotransmitter:sodium symporter activity
O1A01_RS12135	COG0436	Aminotransferase
O1A01_RS12145	COG5582	Belongs to the UPF0302 family
O1A01_RS12155	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS12165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_RS12170	COG3594	Acyltransferase
O1A01_RS12185	COG1278	Cold shock
O1A01_RS12190	COG4191	Histidine kinase
O1A01_RS12195	COG1388	LysM domain
O1A01_RS12195	COG3584	3D domain protein
O1A01_RS12205	COG1404	Belongs to the peptidase S8 family
O1A01_RS12210	COG3620	sequence-specific DNA binding
O1A01_RS12225	COG0596	Alpha beta hydrolase
O1A01_RS12230	COG3011	Protein conserved in bacteria
O1A01_RS12235	COG5522	Integral membrane protein (intg_mem_TP0381)
O1A01_RS12245	COG1349	DNA-binding transcription factor activity
O1A01_RS12250	COG1105	Belongs to the carbohydrate kinase PfkB family
O1A01_RS12255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_RS12255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1A01_RS12255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1A01_RS12265	COG3663	DNA glycosylase
O1A01_RS12275	COG0346	lactoylglutathione lyase activity
O1A01_RS12295	COG0714	Associated with various cellular activities
O1A01_RS12325	COG1842	Phage shock protein A
O1A01_RS12340	COG2197	response regulator
O1A01_RS12350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O1A01_RS12365	COG2873	o-acetylhomoserine
O1A01_RS12370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O1A01_RS12375	COG0326	Molecular chaperone. Has ATPase activity
O1A01_RS12395	COG4152	abc transporter atp-binding protein
O1A01_RS12400	COG2309	aminopeptidase activity
O1A01_RS12425	COG1388	LysM domain
O1A01_RS12425	COG3858	chitin binding
O1A01_RS12440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1A01_RS12455	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
O1A01_RS12465	COG0745	RESPONSE REGULATOR receiver
O1A01_RS12470	COG5002	protein histidine kinase activity
O1A01_RS12485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1A01_RS12495	COG1686	Belongs to the peptidase S11 family
O1A01_RS12515	COG2190	(PTS) system
O1A01_RS12520	COG1263	PTS System
O1A01_RS12520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_RS12525	COG0366	Alpha amylase catalytic
O1A01_RS12535	COG0784	Response regulator, receiver
O1A01_RS12535	COG0835	chemotaxis
O1A01_RS12550	COG1408	metallophosphoesterase
O1A01_RS12555	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS12565	COG2200	EAL domain
O1A01_RS12580	COG4703	Protein of unknown function (DUF1797)
O1A01_RS12585	COG5506	Protein of unknown function (DUF1694)
O1A01_RS12595	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
O1A01_RS12600	COG0517	IMP dehydrogenase activity
O1A01_RS12605	COG2814	Major facilitator Superfamily
O1A01_RS12620	COG0583	DNA-binding transcription factor activity
O1A01_RS12630	COG2171	N-acyltransferase activity
O1A01_RS12635	COG1473	amidohydrolase
O1A01_RS12645	COG0668	transmembrane transport
O1A01_RS12650	COG1132	(ABC) transporter
O1A01_RS12655	COG1132	(ABC) transporter
O1A01_RS12660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O1A01_RS12660	COG1199	ATP-dependent helicase activity
O1A01_RS12680	COG0436	Aminotransferase
O1A01_RS12685	COG0017	Asparaginyl-tRNA synthetase
O1A01_RS12690	COG3935	DnaD domain protein
O1A01_RS12695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O1A01_RS12705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1A01_RS12705	COG4499	WXG100 protein secretion system (Wss), protein YukC
O1A01_RS12710	COG3331	DNA recombination
O1A01_RS12765	COG0392	lysyltransferase activity
O1A01_RS12765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O1A01_RS12770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O1A01_RS12775	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O1A01_RS12780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O1A01_RS12785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1A01_RS12790	COG0505	Belongs to the CarA family
O1A01_RS12800	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O1A01_RS12805	COG0137	argininosuccinate synthase activity
O1A01_RS12810	COG0165	Argininosuccinate lyase
O1A01_RS12820	COG1737	Transcriptional regulator
O1A01_RS12825	COG2188	Transcriptional regulator
O1A01_RS12830	COG0363	glucosamine-6-phosphate deaminase activity
O1A01_RS12835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O1A01_RS12840	COG5609	conserved protein (DUF2294)
O1A01_RS12865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS12870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS12870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS12890	COG1205	dead DEAH box helicase
O1A01_RS12890	COG1111	helicase
O1A01_RS12895	COG3359	exonuclease
O1A01_RS12905	COG4474	Belongs to the UPF0398 family
O1A01_RS12920	COG0116	Belongs to the methyltransferase superfamily
O1A01_RS12935	COG1199	ATP-dependent helicase activity
O1A01_RS12940	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O1A01_RS12945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O1A01_RS12950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O1A01_RS12975	COG3424	synthase
O1A01_RS12980	COG1755	Isoprenylcysteine carboxyl methyltransferase
O1A01_RS12985	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O1A01_RS13015	COG5658	integral membrane protein
O1A01_RS13025	COG1309	transcriptional regulator
O1A01_RS13030	COG1131	(ABC) transporter
O1A01_RS13035	COG3559	Exporter of polyketide antibiotics
O1A01_RS13055	COG0165	Argininosuccinate lyase
O1A01_RS13070	COG0395	ABC-type sugar transport system, permease component
O1A01_RS13075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1A01_RS13095	COG3069	C4-dicarboxylate transmembrane transporter activity
O1A01_RS13105	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS13110	COG3711	transcriptional antiterminator
O1A01_RS13115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_RS13115	COG2190	(PTS) system
O1A01_RS13115	COG1263	PTS System
O1A01_RS13130	COG0346	lactoylglutathione lyase activity
O1A01_RS13135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1A01_RS13145	COG2357	RelA SpoT domain protein
O1A01_RS13170	COG0328	RNA-DNA hybrid ribonuclease activity
O1A01_RS13175	COG0328	RNA-DNA hybrid ribonuclease activity
O1A01_RS13190	COG1278	Cold shock
O1A01_RS13210	COG4974	Belongs to the 'phage' integrase family
O1A01_RS13230	COG1937	Protein conserved in bacteria
O1A01_RS13235	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_RS13245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS13250	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS13250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS13260	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_RS13265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS13265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS13270	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS13290	COG0726	polysaccharide deacetylase
O1A01_RS13295	COG1966	Carbon starvation protein
O1A01_RS13305	COG0517	IMP dehydrogenase activity
O1A01_RS13315	COG0697	spore germination
O1A01_RS13335	COG0517	IMP dehydrogenase activity
O1A01_RS13340	COG0662	Cupin 2, conserved barrel domain protein
O1A01_RS13350	COG1064	alcohol dehydrogenase
O1A01_RS13385	COG2226	methyltransferase
O1A01_RS13405	COG0584	glycerophosphoryl diester phosphodiesterase
O1A01_RS13420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_RS13455	COG1307	EDD domain protein, DegV family
O1A01_RS13465	COG1418	mRNA catabolic process
O1A01_RS13470	COG0488	(ABC) transporter
O1A01_RS13475	COG1413	lyase activity
O1A01_RS13485	COG2136	Putative SAM-dependent methyltransferase
O1A01_RS13485	COG2521	methyltransferase
O1A01_RS13505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O1A01_RS13510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O1A01_RS13520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O1A01_RS13530	COG1307	EDD domain protein, DegV family
O1A01_RS13545	COG1999	signal sequence binding
O1A01_RS13555	COG2755	lipolytic protein G-D-S-L family
O1A01_RS13600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1A01_RS13600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1A01_RS13610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O1A01_RS13615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O1A01_RS13620	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O1A01_RS13625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_RS13630	COG0456	acetyltransferase
O1A01_RS13635	COG3829	transcription factor binding
O1A01_RS13640	COG1509	lysine 2,3-aminomutase activity
O1A01_RS13650	COG4479	Belongs to the UPF0346 family
O1A01_RS13690	COG0813	purine-nucleoside phosphorylase activity
O1A01_RS13695	COG1876	peptidase activity
O1A01_RS13715	COG0400	carboxylic ester hydrolase activity
O1A01_RS13720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O1A01_RS13730	COG3396	Phenylacetate-CoA oxygenase
O1A01_RS13760	COG1024	Enoyl-CoA hydratase
O1A01_RS13765	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_RS13770	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1A01_RS13775	COG0183	Belongs to the thiolase family
O1A01_RS13780	COG3327	negative regulation of DNA-templated transcription, initiation
O1A01_RS13800	COG4120	Belongs to the binding-protein-dependent transport system permease family
O1A01_RS13805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1A01_RS13820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O1A01_RS13840	COG3185	4-Hydroxyphenylpyruvate dioxygenase
O1A01_RS13845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O1A01_RS13850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1A01_RS13855	COG0179	Fumarylacetoacetate (FAA) hydrolase
O1A01_RS13865	COG2340	Cysteine-rich secretory protein family
O1A01_RS13875	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
O1A01_RS13880	COG0534	Mate efflux family protein
O1A01_RS13885	COG0861	Integral membrane protein TerC family
O1A01_RS13890	COG0714	Associated with various cellular activities
O1A01_RS13895	COG4548	von Willebrand factor, type A
O1A01_RS13900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1A01_RS13920	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_RS13930	COG3853	Toxic anion resistance protein (TelA)
O1A01_RS13955	COG3773	Cell wall hydrolase
O1A01_RS13960	COG2226	methyltransferase
O1A01_RS13970	COG0488	(ABC) transporter
O1A01_RS13985	COG1823	symporter activity
O1A01_RS13995	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_RS14005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O1A01_RS14010	COG0514	ATP-dependent DNA helicase (RecQ)
O1A01_RS14020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1A01_RS14025	COG2404	hydrolase activity, acting on ester bonds
O1A01_RS14030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O1A01_RS14040	COG2223	nitrite transmembrane transporter activity
O1A01_RS14045	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
O1A01_RS14050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O1A01_RS14065	COG3344	reverse transcriptase
O1A01_RS14080	COG3546	catalase activity
O1A01_RS14090	COG2340	Cysteine-rich secretory protein family
O1A01_RS14105	COG4589	Belongs to the CDS family
O1A01_RS14115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O1A01_RS14125	COG0514	ATP-dependent DNA helicase (RecQ)
O1A01_RS14130	COG3610	response to peptide
O1A01_RS14135	COG2966	Psort location CytoplasmicMembrane, score
O1A01_RS14150	COG0768	penicillin binding
O1A01_RS14165	COG0542	response to heat
O1A01_RS14180	COG2323	membrane
O1A01_RS14195	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
O1A01_RS14200	COG1733	regulation of RNA biosynthetic process
O1A01_RS14205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1A01_RS14205	COG3153	acetyltransferase
O1A01_RS14210	COG0456	acetyltransferase
O1A01_RS14220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1A01_RS14235	COG3621	Patatin-like phospholipase
O1A01_RS14250	COG0745	RESPONSE REGULATOR receiver
O1A01_RS14255	COG3850	Histidine kinase
O1A01_RS14255	COG5002	protein histidine kinase activity
O1A01_RS14265	COG3212	peptidase
O1A01_RS14270	COG1966	Carbon starvation protein
O1A01_RS14280	COG0003	Pfam Anion-transporting ATPase
O1A01_RS14285	COG3906	Belongs to the UPF0473 family
O1A01_RS14310	COG0697	spore germination
O1A01_RS14315	COG1054	Belongs to the UPF0176 family
O1A01_RS14320	COG0697	spore germination
O1A01_RS14325	COG0077	Prephenate dehydratase
O1A01_RS14335	COG1404	Belongs to the peptidase S8 family
O1A01_RS14345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O1A01_RS14350	COG3739	integral membrane protein
O1A01_RS14355	COG3655	Transcriptional regulator
O1A01_RS14370	COG1247	-acetyltransferase
O1A01_RS14400	COG0346	lactoylglutathione lyase activity
O1A01_RS14405	COG2162	N-hydroxyarylamine O-acetyltransferase activity
O1A01_RS14410	COG0572	uridine kinase
O1A01_RS14430	COG3340	Belongs to the peptidase S51 family
O1A01_RS14465	COG4473	ABC transporter
O1A01_RS14475	COG1271	oxidase subunit
O1A01_RS14480	COG1294	oxidase, subunit
O1A01_RS14485	COG4988	ABC transporter
O1A01_RS14490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O1A01_RS14495	COG1764	response to oxidative stress
O1A01_RS14530	COG0456	acetyltransferase
O1A01_RS14530	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
O1A01_RS14555	COG0406	alpha-ribazole phosphatase activity
O1A01_RS14575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O1A01_RS14585	COG2385	sporulation resulting in formation of a cellular spore
O1A01_RS14605	COG2207	Transcriptional regulator
O1A01_RS14605	COG3708	Transcriptional regulator
O1A01_RS14620	COG1090	epimerase
O1A01_RS14625	COG0778	Nitroreductase
O1A01_RS14695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O1A01_RS14700	COG0671	phosphoesterase, PA-phosphatase related
O1A01_RS14705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O1A01_RS14710	COG0187	DNA topoisomerase II activity
O1A01_RS14715	COG1832	CoA-binding protein
O1A01_RS14720	COG3858	chitin binding
O1A01_RS14725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O1A01_RS14735	COG2843	Capsule synthesis protein
O1A01_RS14740	COG1051	belongs to the nudix hydrolase family
O1A01_RS14745	COG4841	protein insertion into membrane
O1A01_RS14755	COG0824	Thioesterase
O1A01_RS14775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_RS14780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
O1A01_RS14810	COG1484	DNA-dependent DNA replication
O1A01_RS14820	COG4846	Membrane protein involved in cytochrome C biogenesis
O1A01_RS14825	COG2201	protein-glutamate methylesterase activity
O1A01_RS14830	COG0785	Cytochrome C biogenesis protein
O1A01_RS14840	COG1132	(ABC) transporter
O1A01_RS14845	COG1132	(ABC) transporter
O1A01_RS14850	COG3763	UPF0154 protein
O1A01_RS14865	COG4224	UPF0291 protein
O1A01_RS14870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O1A01_RS14885	COG0174	glutamine synthetase
O1A01_RS14890	COG0789	Transcriptional regulator
O1A01_RS14895	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
O1A01_RS14900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O1A01_RS14905	COG2860	membrane
O1A01_RS14910	COG0464	growth
O1A01_RS14925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O1A01_RS14930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O1A01_RS14940	COG4550	Control of competence regulator ComK, YlbF/YmcA
O1A01_RS14945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O1A01_RS14950	COG1013	pyruvate-flavodoxin oxidoreductase activity
O1A01_RS14965	COG2359	stage V sporulation protein S
O1A01_RS14970	COG1692	metallophosphoesterase
O1A01_RS14975	COG1418	mRNA catabolic process
O1A01_RS14980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O1A01_RS14985	COG1546	Belongs to the CinA family
O1A01_RS14985	COG1058	Belongs to the CinA family
O1A01_RS14990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O1A01_RS14995	COG1426	Protein conserved in bacteria
O1A01_RS15010	COG0300	oxidoreductase activity
O1A01_RS15015	COG0612	Peptidase, M16
O1A01_RS15020	COG0612	Peptidase, M16
O1A01_RS15025	COG2188	Transcriptional regulator
O1A01_RS15030	COG4980	gas vesicle protein
O1A01_RS15030	COG1674	ftsk spoiiie
O1A01_RS15040	COG0740	serine-type endopeptidase activity
O1A01_RS15045	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O1A01_RS15050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O1A01_RS15055	COG0527	aspartate kinase activity
O1A01_RS15060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O1A01_RS15065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O1A01_RS15070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O1A01_RS15075	COG1873	PFAM PRC-barrel domain
O1A01_RS15080	COG0612	Peptidase, M16
O1A01_RS15085	COG0726	polysaccharide deacetylase
O1A01_RS15090	COG1185	polyribonucleotide nucleotidyltransferase activity
O1A01_RS15095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O1A01_RS15100	COG0196	riboflavin kinase activity
O1A01_RS15105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O1A01_RS15110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O1A01_RS15115	COG1550	Protein conserved in bacteria
O1A01_RS15125	COG1358	cellular component organization or biogenesis
O1A01_RS15130	COG2740	Nucleic-acid-binding protein implicated in transcription termination
O1A01_RS15135	COG0195	Participates in both transcription termination and antitermination
O1A01_RS15140	COG0779	Required for maturation of 30S ribosomal subunits
O1A01_RS15145	COG2176	DNA-directed DNA polymerase activity
O1A01_RS15150	COG0750	zinc metalloprotease
O1A01_RS15155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O1A01_RS15160	COG4589	Belongs to the CDS family
O1A01_RS15165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O1A01_RS15185	COG0052	Belongs to the universal ribosomal protein uS2 family
O1A01_RS15200	COG1191	sigma factor activity
O1A01_RS15205	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
O1A01_RS15210	COG1776	CheC inhibitor of MCP methylation
O1A01_RS15215	COG0835	chemotaxis
O1A01_RS15220	COG0643	Histidine kinase
O1A01_RS15220	COG2198	Histidine kinase
O1A01_RS15225	COG2201	protein-glutamate methylesterase activity
O1A01_RS15230	COG0455	bacterial-type flagellum organization
O1A01_RS15235	COG1419	protein localization to endoplasmic reticulum
O1A01_RS15240	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O1A01_RS15245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O1A01_RS15250	COG1684	flagellar biosynthetic protein fliR
O1A01_RS15255	COG1987	bacterial-type flagellum assembly
O1A01_RS15260	COG1338	Plays a role in the flagellum-specific transport system
O1A01_RS15265	COG3190	flagellar
O1A01_RS15270	COG2201	protein-glutamate methylesterase activity
O1A01_RS15275	COG1776	CheC inhibitor of MCP methylation
O1A01_RS15275	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O1A01_RS15280	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O1A01_RS15285	COG1580	Controls the rotational direction of flagella during chemotaxis
O1A01_RS15290	COG1582	Flagellar protein (FlbD)
O1A01_RS15295	COG4786	Flagellar basal body rod
O1A01_RS15300	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
O1A01_RS15305	COG3144	bacterial-type flagellum assembly
O1A01_RS15320	COG1157	protein secretion by the type III secretion system
O1A01_RS15325	COG1317	bacterial-type flagellum organization
O1A01_RS15330	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O1A01_RS15335	COG1766	The M ring may be actively involved in energy transduction
O1A01_RS15340	COG1677	Flagellar hook-basal body complex protein FliE
O1A01_RS15345	COG1558	bacterial-type flagellum-dependent cell motility
O1A01_RS15350	COG1815	bacterial-type flagellum-dependent cell motility
O1A01_RS15355	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O1A01_RS15360	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O1A01_RS15365	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O1A01_RS15370	COG4974	Belongs to the 'phage' integrase family
O1A01_RS15375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O1A01_RS15380	COG0758	DNA mediated transformation
O1A01_RS15385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
O1A01_RS15390	COG0045	succinate-CoA ligase (ADP-forming) activity
O1A01_RS15395	COG2257	FlhB HrpN YscU SpaS Family
O1A01_RS15410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O1A01_RS15430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O1A01_RS15435	COG1837	Belongs to the UPF0109 family
O1A01_RS15445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O1A01_RS15450	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
O1A01_RS15455	COG0552	protein localization to endoplasmic reticulum
O1A01_RS15460	COG1196	nuclear chromosome segregation
O1A01_RS15465	COG0571	ribonuclease III activity
O1A01_RS15470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O1A01_RS15475	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS15480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O1A01_RS15485	COG0416	fatty acid biosynthetic process
O1A01_RS15495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O1A01_RS15500	COG1760	l-serine dehydratase
O1A01_RS15505	COG1760	l-serine dehydratase
O1A01_RS15510	COG1461	Dihydroxyacetone kinase
O1A01_RS15515	COG1302	Protein conserved in bacteria
O1A01_RS15520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O1A01_RS15530	COG1564	THIamine pyrophosphokinase
O1A01_RS15535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O1A01_RS15540	COG1162	GTPase activity
O1A01_RS15545	COG2815	serine threonine protein kinase
O1A01_RS15545	COG0515	serine threonine protein kinase
O1A01_RS15550	COG0631	protein serine/threonine phosphatase activity
O1A01_RS15555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O1A01_RS15560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O1A01_RS15560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O1A01_RS15565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O1A01_RS15575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O1A01_RS15580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O1A01_RS15585	COG1758	RNA polymerase activity
O1A01_RS15590	COG0194	GDP metabolic process
O1A01_RS15595	COG2052	Domain of unknown function (DUF370)
O1A01_RS15600	COG1561	YicC-like family, N-terminal region
O1A01_RS15605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O1A01_RS15610	COG1293	RNA-binding protein homologous to eukaryotic snRNP
O1A01_RS15615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O1A01_RS15620	COG0284	orotidine-5'-phosphate decarboxylase activity
O1A01_RS15625	COG0167	dihydroorotate dehydrogenase activity
O1A01_RS15630	COG0543	2 iron, 2 sulfur cluster binding
O1A01_RS15635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O1A01_RS15640	COG0505	Belongs to the CarA family
O1A01_RS15645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O1A01_RS15650	COG0540	Belongs to the ATCase OTCase family
O1A01_RS15655	COG2233	PERMEase
O1A01_RS15660	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
O1A01_RS15665	COG0564	pseudouridine synthase activity
O1A01_RS15675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O1A01_RS15680	COG3599	regulation of cell shape
O1A01_RS15685	COG2302	S4 RNA-binding domain
O1A01_RS15690	COG0762	integral membrane protein
O1A01_RS15695	COG1799	cell septum assembly
O1A01_RS15700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O1A01_RS15705	COG1496	oxidoreductase activity
O1A01_RS15710	COG1873	PFAM PRC-barrel domain
O1A01_RS15720	COG1191	sigma factor activity
O1A01_RS15725	COG1191	sigma factor activity
O1A01_RS15735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O1A01_RS15740	COG0849	cell division
O1A01_RS15745	COG3856	small basic protein
O1A01_RS15750	COG3879	Bacterial protein of unknown function (DUF881)
O1A01_RS15755	COG3879	Bacterial protein of unknown function (DUF881)
O1A01_RS15760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O1A01_RS15765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O1A01_RS15770	COG0772	Belongs to the SEDS family
O1A01_RS15780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O1A01_RS15790	COG0768	penicillin binding
O1A01_RS15795	COG0768	penicillin binding
O1A01_RS15800	COG4839	cell division protein FtsL
O1A01_RS15805	COG0275	rRNA processing
O1A01_RS15810	COG2001	Belongs to the MraZ family
O1A01_RS15815	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
O1A01_RS15825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O1A01_RS15830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1A01_RS15835	COG0511	ligase activity, forming carbon-carbon bonds
O1A01_RS15840	COG0439	Biotin carboxylase
O1A01_RS15845	COG0454	-acetyltransferase
O1A01_RS15855	COG1024	Enoyl-CoA hydratase
O1A01_RS15860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O1A01_RS15865	COG1399	metal-binding, possibly nucleic acid-binding protein
O1A01_RS15870	COG1323	Belongs to the UPF0348 family
O1A01_RS15875	COG3480	Lon protease (S16) C-terminal proteolytic domain
O1A01_RS15880	COG1752	Esterase of the alpha-beta hydrolase superfamily
O1A01_RS15885	COG3314	Sporulation integral membrane protein YlbJ
O1A01_RS15890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O1A01_RS15895	COG0742	ribosomal rna small subunit methyltransferase
O1A01_RS15920	COG3679	Belongs to the UPF0342 family
O1A01_RS15950	COG2340	Cysteine-rich secretory protein family
O1A01_RS15955	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
O1A01_RS15960	COG2340	Cysteine-rich secretory protein family
O1A01_RS15970	COG0628	permease
O1A01_RS15980	COG3336	cytochrome c oxidase
O1A01_RS16005	COG0109	protoheme IX farnesyltransferase activity
O1A01_RS16010	COG1612	heme a metabolic process
O1A01_RS16015	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
O1A01_RS16020	COG4838	Belongs to the UPF0358 family
O1A01_RS16025	COG2066	Belongs to the glutaminase family
O1A01_RS16030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O1A01_RS16035	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O1A01_RS16045	COG4896	Protein conserved in bacteria
O1A01_RS16060	COG1217	gtp-binding protein TYPA
O1A01_RS16070	COG0483	inositol monophosphate 1-phosphatase activity
O1A01_RS16080	COG4493	Belongs to the UPF0637 family
O1A01_RS16085	COG4476	Belongs to the UPF0223 family
O1A01_RS16095	COG1982	Orn Lys Arg decarboxylase major
O1A01_RS16105	COG1846	Transcriptional regulator
O1A01_RS16110	COG0386	Belongs to the glutathione peroxidase family
O1A01_RS16135	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1A01_RS16140	COG0022	dehydrogenase e1 component
O1A01_RS16160	COG5503	Protein of unknown function (DUF1447)
O1A01_RS16165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O1A01_RS16170	COG0569	domain protein
O1A01_RS16175	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
O1A01_RS16200	COG0438	transferase activity, transferring glycosyl groups
O1A01_RS16205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O1A01_RS16210	COG1803	Methylglyoxal synthase
O1A01_RS16215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O1A01_RS16220	COG1694	Mazg nucleotide pyrophosphohydrolase
O1A01_RS16225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O1A01_RS16230	COG2738	Putative neutral zinc metallopeptidase
O1A01_RS16240	COG4347	Protein of unknown function (DUF1405)
O1A01_RS16250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O1A01_RS16265	COG5582	Belongs to the UPF0302 family
O1A01_RS16270	COG0457	Tetratricopeptide repeat
O1A01_RS16280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O1A01_RS16285	COG0287	Prephenate dehydrogenase
O1A01_RS16290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O1A01_RS16295	COG0159	tryptophan synthase activity
O1A01_RS16300	COG0133	tryptophan synthase activity
O1A01_RS16305	COG0135	phosphoribosylanthranilate isomerase activity
O1A01_RS16310	COG0134	indole-3-glycerol-phosphate synthase activity
O1A01_RS16315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O1A01_RS16320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O1A01_RS16325	COG4401	Chorismate mutase type I
O1A01_RS16330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O1A01_RS16335	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O1A01_RS16340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O1A01_RS16345	COG0105	UTP biosynthetic process
O1A01_RS16350	COG0142	geranyltranstransferase activity
O1A01_RS16355	COG2226	methyltransferase
O1A01_RS16360	COG0142	geranyltranstransferase activity
O1A01_RS16370	COG0302	gtp cyclohydrolase
O1A01_RS16375	COG0776	regulation of translation
O1A01_RS16380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O1A01_RS16400	COG1160	GTP binding
O1A01_RS16425	COG1304	FMN binding
O1A01_RS16430	COG0539	negative regulation of cytoplasmic translation
O1A01_RS16435	COG0204	Acyl-transferase
O1A01_RS16455	COG2959	enzyme of heme biosynthesis
O1A01_RS16460	COG3409	Peptidoglycan-binding domain 1 protein
O1A01_RS16460	COG3773	Cell wall hydrolase
O1A01_RS16465	COG2339	peptidase activity
O1A01_RS16475	COG0492	ferredoxin-NADP+ reductase activity
O1A01_RS16480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O1A01_RS16485	COG4862	establishment of competence for transformation
O1A01_RS16490	COG1408	metallophosphoesterase
O1A01_RS16505	COG1388	LysM domain
O1A01_RS16510	COG1266	CAAX protease self-immunity
O1A01_RS16515	COG0514	ATP-dependent DNA helicase (RecQ)
O1A01_RS16520	COG4955	Helix-turn-helix domain
O1A01_RS16525	COG1141	Ferredoxin
O1A01_RS16530	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
O1A01_RS16545	COG1595	DNA-templated transcription, initiation
O1A01_RS16560	COG5002	protein histidine kinase activity
O1A01_RS16565	COG0745	RESPONSE REGULATOR receiver
O1A01_RS16570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O1A01_RS16575	COG1333	cytochrome c biogenesis protein
O1A01_RS16580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_RS16585	COG1187	pseudouridine synthase activity
O1A01_RS16590	COG0700	Nucleoside recognition
O1A01_RS16595	COG2715	membrane protein required for spore maturation
O1A01_RS16600	COG1686	Belongs to the peptidase S11 family
O1A01_RS16625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O1A01_RS16630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
O1A01_RS16635	COG1547	Domain of unknown function (DUF309)
O1A01_RS16645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O1A01_RS16650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_RS16650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_RS16655	COG0307	riboflavin synthase, alpha
O1A01_RS16660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O1A01_RS16660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O1A01_RS16665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O1A01_RS16680	COG0697	spore germination
O1A01_RS16695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1A01_RS16720	COG2172	sigma factor antagonist activity
O1A01_RS16730	COG1686	Belongs to the peptidase S11 family
O1A01_RS16750	COG4974	Belongs to the 'phage' integrase family
O1A01_RS16760	COG0735	belongs to the Fur family
O1A01_RS16765	COG1300	Membrane
O1A01_RS16775	COG1379	DNA repair
O1A01_RS16780	COG0494	nUDIX hydrolase
O1A01_RS16790	COG0667	Aldo Keto reductase
O1A01_RS16800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O1A01_RS16805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O1A01_RS16810	COG0183	Belongs to the thiolase family
O1A01_RS16815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O1A01_RS16820	COG1073	alpha beta
O1A01_RS16835	COG0494	nUDIX hydrolase
O1A01_RS16840	COG2223	nitrite transmembrane transporter activity
O1A01_RS16845	COG1882	Formate acetyltransferase
O1A01_RS16850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
O1A01_RS16860	COG2076	Multidrug Resistance protein
O1A01_RS16865	COG2076	Multidrug Resistance protein
O1A01_RS16895	COG1595	DNA-templated transcription, initiation
O1A01_RS16925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O1A01_RS16950	COG0300	oxidoreductase activity
O1A01_RS16955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS16960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O1A01_RS16985	COG1131	(ABC) transporter
O1A01_RS17030	COG0572	uridine kinase
O1A01_RS17050	COG2824	Alkylphosphonate utilization operon protein PhnA
O1A01_RS17070	COG1247	-acetyltransferase
O1A01_RS17080	COG2247	cell wall binding repeat
O1A01_RS17080	COG2385	sporulation resulting in formation of a cellular spore
O1A01_RS17085	COG4187	Peptidase family M20/M25/M40
O1A01_RS17090	COG1902	pentaerythritol trinitrate reductase activity
O1A01_RS17100	COG0346	lactoylglutathione lyase activity
O1A01_RS17105	COG0681	Belongs to the peptidase S26 family
O1A01_RS17125	COG1131	(ABC) transporter
O1A01_RS17135	COG2197	response regulator
O1A01_RS17140	COG4585	Histidine kinase
O1A01_RS17145	COG1234	tRNA 3'-trailer cleavage
O1A01_RS17155	COG0546	phosphoglycolate phosphatase activity
O1A01_RS17170	COG1556	Lactate utilization protein
O1A01_RS17175	COG1139	Iron-sulfur cluster binding protein
O1A01_RS17180	COG0247	lactate metabolic process
O1A01_RS17185	COG0277	FAD linked oxidase domain protein
O1A01_RS17190	COG0247	lactate metabolic process
O1A01_RS17205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O1A01_RS17215	COG2195	Cleaves the N-terminal amino acid of tripeptides
O1A01_RS17220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1A01_RS17225	COG0346	lactoylglutathione lyase activity
O1A01_RS17245	COG1376	ErfK ybiS ycfS ynhG family protein
O1A01_RS17250	COG4129	membrane
O1A01_RS17255	COG1164	Oligoendopeptidase f
O1A01_RS17265	COG1703	isobutyryl-CoA mutase activity
O1A01_RS17270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1A01_RS17270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1A01_RS17275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1A01_RS17305	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1A01_RS17310	COG0022	dehydrogenase e1 component
O1A01_RS17315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O1A01_RS17320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O1A01_RS17335	COG0280	phosphate acetyltransferase
O1A01_RS17340	COG3829	transcription factor binding
O1A01_RS17340	COG3290	protein histidine kinase activity
O1A01_RS17350	COG0584	glycerophosphoryl diester phosphodiesterase
O1A01_RS17355	COG3093	addiction module antidote protein HigA
O1A01_RS17360	COG0745	RESPONSE REGULATOR receiver
O1A01_RS17365	COG0750	zinc metalloprotease
O1A01_RS17370	COG0497	DNA recombination
O1A01_RS17375	COG1438	arginine binding
O1A01_RS17380	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
O1A01_RS17385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O1A01_RS17405	COG1570	exodeoxyribonuclease VII activity
O1A01_RS17410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O1A01_RS17415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O1A01_RS17420	COG1302	Protein conserved in bacteria
O1A01_RS17425	COG0439	Biotin carboxylase
O1A01_RS17430	COG0511	ligase activity, forming carbon-carbon bonds
O1A01_RS17470	COG3854	ATPases associated with a variety of cellular activities
O1A01_RS17480	COG1131	(ABC) transporter
O1A01_RS17490	COG0366	Alpha amylase catalytic
O1A01_RS17500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O1A01_RS17505	COG0006	proline dipeptidase activity
O1A01_RS17510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O1A01_RS17525	COG1752	Esterase of the alpha-beta hydrolase superfamily
O1A01_RS17555	COG2318	DinB family
O1A01_RS17565	COG0697	spore germination
O1A01_RS17570	COG0531	amino acid
O1A01_RS17585	COG1309	transcriptional regulator
O1A01_RS17600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O1A01_RS17605	COG0095	Lipoate-protein ligase
O1A01_RS17610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS17625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O1A01_RS17630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O1A01_RS17635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1A01_RS17655	COG3275	phosphorelay sensor kinase activity
O1A01_RS17665	COG1966	Carbon starvation protein
O1A01_RS17680	COG1012	belongs to the aldehyde dehydrogenase family
O1A01_RS17700	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS17715	COG1272	protein, Hemolysin III
O1A01_RS17735	COG0793	Belongs to the peptidase S41A family
O1A01_RS17740	COG0456	acetyltransferase
O1A01_RS17810	COG2318	DinB family
O1A01_RS17815	COG2333	competence protein COMEC
O1A01_RS17815	COG0658	competence protein
O1A01_RS17825	COG2124	cytochrome p450
O1A01_RS17830	COG1376	ErfK ybiS ycfS ynhG family protein
O1A01_RS17840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O1A01_RS17845	COG0697	spore germination
O1A01_RS17850	COG0592	DNA-directed DNA polymerase activity
O1A01_RS17865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O1A01_RS17870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_RS17900	COG4970	Tfp pilus assembly protein FimT
O1A01_RS17905	COG4537	Required for transformation and DNA binding
O1A01_RS17910	COG1459	type II secretion system
O1A01_RS17915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O1A01_RS17920	COG4191	Histidine kinase
O1A01_RS17950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS17965	COG0011	TIGRFAM Protein of
O1A01_RS17980	COG1368	sulfuric ester hydrolase activity
O1A01_RS17985	COG1940	carbohydrate kinase activity
O1A01_RS17995	COG0697	spore germination
O1A01_RS18005	COG0457	Tetratricopeptide repeat
O1A01_RS18005	COG0705	Rhomboid family
O1A01_RS18025	COG0039	L-malate dehydrogenase activity
O1A01_RS18035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O1A01_RS18065	COG1172	Belongs to the binding-protein-dependent transport system permease family
O1A01_RS18070	COG1129	ABC transporter
O1A01_RS18085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O1A01_RS18090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
O1A01_RS18095	COG0640	Transcriptional regulator
O1A01_RS18110	COG0659	secondary active sulfate transmembrane transporter activity
O1A01_RS18115	COG0704	Plays a role in the regulation of phosphate uptake
O1A01_RS18120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O1A01_RS18125	COG0581	inorganic phosphate transmembrane transporter activity
O1A01_RS18130	COG0573	inorganic phosphate transmembrane transporter activity
O1A01_RS18135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O1A01_RS18140	COG0768	penicillin binding
O1A01_RS18145	COG0477	Major facilitator Superfamily
O1A01_RS18155	COG0205	6-phosphofructokinase activity
O1A01_RS18175	COG2839	Protein conserved in bacteria
O1A01_RS18185	COG5521	maltodextrose utilization protein MalA
O1A01_RS18195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O1A01_RS18200	COG4709	membrane
O1A01_RS18205	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
O1A01_RS18220	COG0735	belongs to the Fur family
O1A01_RS18225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O1A01_RS18230	COG1121	(ABC) transporter
O1A01_RS18235	COG4191	Histidine kinase
O1A01_RS18245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O1A01_RS18260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O1A01_RS18265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O1A01_RS18270	COG2384	SAM-dependent methyltransferase
O1A01_RS18275	COG2010	Cytochrome c
O1A01_RS18280	COG1960	acyl-CoA dehydrogenase activity
O1A01_RS18290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O1A01_RS18295	COG0358	DNA primase activity
O1A01_RS18300	COG1671	Belongs to the UPF0178 family
O1A01_RS18305	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O1A01_RS18310	COG0517	IMP dehydrogenase activity
O1A01_RS18315	COG0751	glycine-tRNA ligase activity
O1A01_RS18325	COG1381	Involved in DNA repair and RecF pathway recombination
O1A01_RS18335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O1A01_RS18340	COG0295	cytidine deaminase activity
O1A01_RS18345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O1A01_RS18355	COG1480	7TM receptor with intracellular HD hydrolase
O1A01_RS18360	COG1702	phosphate starvation-inducible protein PhoH
O1A01_RS18375	COG0494	nUDIX hydrolase
O1A01_RS18385	COG4864	UPF0365 protein
O1A01_RS18390	COG1030	water channel activity
O1A01_RS18395	COG1610	YqeY-like protein
O1A01_RS18410	COG1283	sodium-dependent phosphate transmembrane transporter activity
O1A01_RS18415	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O1A01_RS18430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O1A01_RS18435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O1A01_RS18440	COG2264	protein methyltransferase activity
O1A01_RS18445	COG0484	heat shock protein binding
O1A01_RS18450	COG0443	Heat shock 70 kDa protein
O1A01_RS18460	COG1420	regulation of RNA biosynthetic process
O1A01_RS18465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O1A01_RS18480	COG0860	N-Acetylmuramoyl-L-alanine amidase
O1A01_RS18495	COG1466	dna polymerase III delta subunit
O1A01_RS18505	COG0658	competence protein
O1A01_RS18505	COG2333	competence protein COMEC
O1A01_RS18510	COG2131	deaminase
O1A01_RS18515	COG1555	photosystem II stabilization
O1A01_RS18515	COG1596	polysaccharide export
O1A01_RS18520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O1A01_RS18525	COG2226	methyltransferase
O1A01_RS18530	COG0799	negative regulation of ribosome biogenesis
O1A01_RS18535	COG1713	HD superfamily hydrolase involved in NAD metabolism
O1A01_RS18540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O1A01_RS18545	COG1534	Rna-binding protein
O1A01_RS18555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O1A01_RS18560	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
O1A01_RS18570	COG0688	phosphatidylethanolamine metabolic process
O1A01_RS18600	COG1525	nuclease
O1A01_RS18625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O1A01_RS18630	COG1595	DNA-templated transcription, initiation
O1A01_RS18640	COG0626	cystathionine gamma-synthase activity
O1A01_RS18645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O1A01_RS18650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O1A01_RS18655	COG2226	methyltransferase
O1A01_RS18670	COG0768	penicillin binding
O1A01_RS18675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O1A01_RS18680	COG0572	uridine kinase
O1A01_RS18685	COG0826	peptidase U32
O1A01_RS18690	COG0826	peptidase U32
O1A01_RS18695	COG4122	O-methyltransferase activity
O1A01_RS18700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O1A01_RS18705	COG3906	Belongs to the UPF0473 family
O1A01_RS18710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O1A01_RS18730	COG0628	permease
O1A01_RS18735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O1A01_RS18755	COG3881	PFAM PRC-barrel domain
O1A01_RS18760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O1A01_RS18765	COG0457	Tetratricopeptide repeat
O1A01_RS18770	COG0482	sulfurtransferase activity
O1A01_RS18775	COG1104	cysteine desulfurase activity
O1A01_RS18780	COG1959	2 iron, 2 sulfur cluster binding
O1A01_RS18785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O1A01_RS18800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O1A01_RS18815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O1A01_RS18820	COG0124	histidyl-tRNA synthetase
O1A01_RS18830	COG0860	N-Acetylmuramoyl-L-alanine amidase
O1A01_RS18830	COG3103	Sh3 type 3 domain protein
O1A01_RS18830	COG4991	sh3 domain protein
O1A01_RS18835	COG1490	D-aminoacyl-tRNA deacylase activity
O1A01_RS18840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O1A01_RS18845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O1A01_RS18850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O1A01_RS18850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
O1A01_RS18855	COG5416	Lipopolysaccharide assembly protein A domain
O1A01_RS18860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O1A01_RS18865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O1A01_RS18865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O1A01_RS18875	COG2244	polysaccharide biosynthetic process
O1A01_RS18880	COG2323	membrane
O1A01_RS18890	COG1862	Preprotein translocase
O1A01_RS18900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O1A01_RS18910	COG2255	four-way junction helicase activity
O1A01_RS18915	COG0632	four-way junction helicase activity
O1A01_RS18935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O1A01_RS18955	COG0157	Belongs to the NadC ModD family
O1A01_RS18960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O1A01_RS18965	COG1104	cysteine desulfurase activity
O1A01_RS18970	COG1827	regulation of RNA biosynthetic process
O1A01_RS18975	COG0366	Alpha amylase catalytic
O1A01_RS18980	COG4492	Belongs to the UPF0735 family
O1A01_RS18990	COG3290	protein histidine kinase activity
O1A01_RS19000	COG2868	ribosomal protein
O1A01_RS19005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O1A01_RS19010	COG1530	ribonuclease E activity
O1A01_RS19015	COG1994	Peptidase M50
O1A01_RS19020	COG0739	heme binding
O1A01_RS19025	COG2894	cell division
O1A01_RS19030	COG0850	regulation of cytokinetic process
O1A01_RS19035	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
O1A01_RS19040	COG1792	Involved in formation and maintenance of cell shape
O1A01_RS19045	COG1077	Cell shape determining protein MreB Mrl
O1A01_RS19050	COG2003	Belongs to the UPF0758 family
O1A01_RS19080	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O1A01_RS19090	COG1459	type II secretion system
O1A01_RS19100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O1A01_RS19125	COG3706	GGDEF domain
O1A01_RS19130	COG0285	dihydrofolate synthase activity
O1A01_RS19135	COG0525	valine-tRNA ligase activity
O1A01_RS19145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O1A01_RS19150	COG1388	LysM domain
O1A01_RS19150	COG1388	LysM domain
O1A01_RS19155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O1A01_RS19160	COG0113	porphobilinogen synthase activity
O1A01_RS19165	COG1587	Uroporphyrinogen-III synthase
O1A01_RS19170	COG0181	hydroxymethylbilane synthase activity
O1A01_RS19175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O1A01_RS19195	COG0765	amino acid transport
O1A01_RS19205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O1A01_RS19210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O1A01_RS19215	COG1067	ATP-dependent peptidase activity
O1A01_RS19215	COG0470	DNA polymerase III
O1A01_RS19220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O1A01_RS19225	COG0544	peptidyl-prolyl cis-trans isomerase activity
O1A01_RS19230	COG1477	protein flavinylation
O1A01_RS19230	COG0457	Tetratricopeptide repeat
O1A01_RS19240	COG0622	Phosphoesterase
O1A01_RS19245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O1A01_RS19255	COG5401	PFAM Sporulation and spore germination
O1A01_RS19265	COG1846	Transcriptional regulator
O1A01_RS19270	COG2197	response regulator
O1A01_RS19275	COG0824	Thioesterase
O1A01_RS19280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O1A01_RS19285	COG1053	succinate dehydrogenase
O1A01_RS19290	COG2009	succinate dehydrogenase
O1A01_RS19295	COG1719	4-vinyl reductase, 4VR
O1A01_RS19305	COG0322	excinuclease ABC activity
O1A01_RS19310	COG3118	belongs to the thioredoxin family
O1A01_RS19315	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
O1A01_RS19320	COG2086	electron transfer activity
O1A01_RS19325	COG1024	Enoyl-CoA hydratase
O1A01_RS19330	COG1309	transcriptional regulator
O1A01_RS19335	COG0318	PFAM AMP-dependent synthetase and ligase
O1A01_RS19340	COG3766	membrane
O1A01_RS19345	COG1193	negative regulation of DNA recombination
O1A01_RS19350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O1A01_RS19350	COG1796	DNA polymerase
O1A01_RS19355	COG1286	toxin biosynthetic process
O1A01_RS19360	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
O1A01_RS19365	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O1A01_RS19380	COG0072	phenylalanine-tRNA ligase activity
O1A01_RS19380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1A01_RS19385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O1A01_RS19405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O1A01_RS19415	COG1363	Peptidase, m42
O1A01_RS19440	COG0398	Pfam SNARE associated Golgi protein
O1A01_RS19445	COG3326	Membrane
O1A01_RS19450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O1A01_RS19455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O1A01_RS19460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O1A01_RS19465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O1A01_RS19475	COG3611	Membrane attachment protein
O1A01_RS19480	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O1A01_RS19490	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
O1A01_RS19495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O1A01_RS19505	COG1971	Probably functions as a manganese efflux pump
O1A01_RS19510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O1A01_RS19515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1A01_RS19515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1A01_RS19520	COG0330	HflC and HflK could
O1A01_RS19525	COG0330	HflC and HflK could
O1A01_RS19530	COG5002	protein histidine kinase activity
O1A01_RS19535	COG0745	RESPONSE REGULATOR receiver
O1A01_RS19545	COG0039	L-malate dehydrogenase activity
O1A01_RS19550	COG0538	isocitrate dehydrogenase activity
O1A01_RS19555	COG0372	Belongs to the citrate synthase family
O1A01_RS19560	COG2707	UPF0756 membrane protein
O1A01_RS19565	COG0628	permease
O1A01_RS19570	COG3030	protein affecting phage T7 exclusion by the F plasmid
O1A01_RS19580	COG0205	6-phosphofructokinase activity
O1A01_RS19585	COG0825	malonyl-CoA metabolic process
O1A01_RS19595	COG1725	Transcriptional regulator
O1A01_RS19600	COG0281	malic enzyme
O1A01_RS19605	COG0587	DNA-directed DNA polymerase activity
O1A01_RS19620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O1A01_RS19630	COG4109	DRTGG domain
O1A01_RS19640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O1A01_RS19645	COG0006	proline dipeptidase activity
O1A01_RS19650	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS19660	COG0589	response to stress
O1A01_RS19680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O1A01_RS19685	COG0827	DNA restriction-modification system
O1A01_RS19690	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
O1A01_RS19695	COG3874	Sporulation protein YtfJ
O1A01_RS19705	COG1714	RDD family
O1A01_RS19710	COG0616	signal peptide processing
O1A01_RS19715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O1A01_RS19720	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O1A01_RS19730	COG0301	tRNA thio-modification
O1A01_RS19735	COG1104	cysteine desulfurase activity
O1A01_RS19740	COG1114	Component of the transport system for branched-chain amino acids
O1A01_RS19745	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
O1A01_RS19750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O1A01_RS19755	COG1309	transcriptional regulator
O1A01_RS19760	COG1956	GAF domain-containing protein
O1A01_RS19765	COG0626	cystathionine gamma-synthase activity
O1A01_RS19770	COG2199	diguanylate cyclase activity
O1A01_RS19770	COG2203	Gaf domain
O1A01_RS19780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O1A01_RS19785	COG2207	Transcriptional regulator
O1A01_RS19790	COG1263	PTS System
O1A01_RS19790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_RS19790	COG2190	(PTS) system
O1A01_RS19810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1A01_RS19815	COG0454	-acetyltransferase
O1A01_RS19820	COG0517	IMP dehydrogenase activity
O1A01_RS19825	COG0123	including yeast histone deacetylase and acetoin utilization protein
O1A01_RS19835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O1A01_RS19845	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
O1A01_RS19845	COG1605	Chorismate mutase
O1A01_RS19850	COG4980	gas vesicle protein
O1A01_RS19865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O1A01_RS19875	COG1674	ftsk spoiiie
O1A01_RS19880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1A01_RS19885	COG4848	Belongs to the UPF0354 family
O1A01_RS19890	COG1404	Belongs to the peptidase S8 family
O1A01_RS19890	COG4412	M6 family metalloprotease domain protein
O1A01_RS19895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_RS19905	COG0840	transmembrane signaling receptor activity
O1A01_RS19925	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
O1A01_RS19930	COG1363	Peptidase, m42
O1A01_RS19935	COG5584	Small secreted protein
O1A01_RS19940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS19945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O1A01_RS19955	COG0510	thiamine kinase activity
O1A01_RS19960	COG1523	belongs to the glycosyl hydrolase 13 family
O1A01_RS19970	COG1346	cytolysis
O1A01_RS19975	COG1380	Effector of murein hydrolase LrgA
O1A01_RS19985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O1A01_RS19995	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
O1A01_RS20000	COG1472	Belongs to the glycosyl hydrolase 3 family
O1A01_RS20005	COG3876	Protein conserved in bacteria
O1A01_RS20015	COG3842	ATPase activity
O1A01_RS20020	COG0395	ABC-type sugar transport system, permease component
O1A01_RS20025	COG1175	transmembrane transport
O1A01_RS20035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O1A01_RS20050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_RS20060	COG1131	(ABC) transporter
O1A01_RS20065	COG1349	DNA-binding transcription factor activity
O1A01_RS20070	COG1187	pseudouridine synthase activity
O1A01_RS20080	COG2244	polysaccharide biosynthetic process
O1A01_RS20090	COG2081	HI0933 family
O1A01_RS20105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS20110	COG0495	leucyl-tRNA aminoacylation
O1A01_RS20120	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS20125	COG2610	gluconate transmembrane transporter activity
O1A01_RS20140	COG2814	Major facilitator Superfamily
O1A01_RS20155	COG1242	4 iron, 4 sulfur cluster binding
O1A01_RS20160	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
O1A01_RS20170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O1A01_RS20180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O1A01_RS20185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O1A01_RS20200	COG2267	carboxylic ester hydrolase activity
O1A01_RS20205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O1A01_RS20215	COG0438	transferase activity, transferring glycosyl groups
O1A01_RS20225	COG0217	transcriptional regulatory protein
O1A01_RS20230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O1A01_RS20240	COG1506	peptidase
O1A01_RS20245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O1A01_RS20250	COG1116	anion transmembrane transporter activity
O1A01_RS20255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1A01_RS20260	COG0494	nUDIX hydrolase
O1A01_RS20275	COG0783	Belongs to the Dps family
O1A01_RS20290	COG0701	Predicted permease
O1A01_RS20295	COG1854	S-ribosylhomocysteine lyase activity
O1A01_RS20300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O1A01_RS20305	COG0288	reversible hydration of carbon dioxide
O1A01_RS20320	COG1404	Belongs to the peptidase S8 family
O1A01_RS20325	COG0523	cobalamin synthesis protein
O1A01_RS20335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O1A01_RS20340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O1A01_RS20340	COG1321	iron dependent repressor
O1A01_RS20345	COG1121	(ABC) transporter
O1A01_RS20350	COG0803	Belongs to the bacterial solute-binding protein 9 family
O1A01_RS20355	COG0318	PFAM AMP-dependent synthetase and ligase
O1A01_RS20360	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
O1A01_RS20365	COG0596	Alpha beta hydrolase
O1A01_RS20370	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O1A01_RS20375	COG1169	isochorismate synthase
O1A01_RS20380	COG1575	Belongs to the MenA family. Type 1 subfamily
O1A01_RS20385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O1A01_RS20395	COG0058	SHG alpha-glucan phosphorylase activity
O1A01_RS20400	COG0297	glycogen (starch) synthase activity
O1A01_RS20405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O1A01_RS20410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O1A01_RS20565	COG1285	pathogenesis
O1A01_RS20580	COG2223	nitrite transmembrane transporter activity
O1A01_RS20590	COG0243	molybdopterin cofactor binding
O1A01_RS20595	COG0437	4 iron, 4 sulfur cluster binding
O1A01_RS20600	COG0723	plastoquinol--plastocyanin reductase activity
O1A01_RS20615	COG0489	protein tyrosine kinase activity
O1A01_RS20625	COG1366	Belongs to the anti-sigma-factor antagonist family
O1A01_RS20640	COG1280	lysine exporter protein (LysE YggA)
O1A01_RS20655	COG1113	amino acid transport
O1A01_RS20660	COG1280	lysine exporter protein (LysE YggA)
O1A01_RS20670	COG3314	Sporulation integral membrane protein YlbJ
O1A01_RS20675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O1A01_RS20680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O1A01_RS20685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O1A01_RS20700	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
O1A01_RS20705	COG0673	inositol 2-dehydrogenase activity
O1A01_RS20720	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS20735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O1A01_RS20755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O1A01_RS20755	COG2111	Na H antiporter
O1A01_RS20760	COG2111	Na H antiporter
O1A01_RS20765	COG1006	Multisubunit Na H antiporter MnhC subunit
O1A01_RS20770	COG0651	ATP synthesis coupled electron transport
O1A01_RS20775	COG1863	multisubunit Na H antiporter MnhE subunit
O1A01_RS20780	COG2212	antiporter activity
O1A01_RS20785	COG1320	monovalent cation:proton antiporter activity
O1A01_RS20790	COG1979	alcohol dehydrogenase
O1A01_RS20795	COG2155	Conserved Protein
O1A01_RS20800	COG1098	S1 RNA binding domain
O1A01_RS20810	COG2267	carboxylic ester hydrolase activity
O1A01_RS20820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
O1A01_RS20830	COG2032	superoxide dismutase activity
O1A01_RS20840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O1A01_RS20850	COG5018	Exonuclease
O1A01_RS20855	COG2814	Major facilitator Superfamily
O1A01_RS20865	COG2050	protein possibly involved in aromatic compounds catabolism
O1A01_RS20890	COG1595	DNA-templated transcription, initiation
O1A01_RS20900	COG4555	ABC transporter
O1A01_RS20905	COG0772	Belongs to the SEDS family
O1A01_RS20910	COG0772	Belongs to the SEDS family
O1A01_RS20920	COG1268	BioY protein
O1A01_RS20925	COG2056	Na+-H+ antiporter family
O1A01_RS20945	COG0697	spore germination
O1A01_RS20950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O1A01_RS20960	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
O1A01_RS20965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O1A01_RS20970	COG3584	3D domain protein
O1A01_RS20990	COG1252	NADH dehydrogenase
O1A01_RS21005	COG0316	Belongs to the HesB IscA family
O1A01_RS21010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O1A01_RS21015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O1A01_RS21025	COG1252	NADH dehydrogenase
O1A01_RS21030	COG4837	Protein of unknown function (DUF1462)
O1A01_RS21040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O1A01_RS21045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O1A01_RS21050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O1A01_RS21055	COG0647	UMP catabolic process
O1A01_RS21060	COG2445	Protein of unknown function DUF86
O1A01_RS21075	COG4470	Protein conserved in bacteria
O1A01_RS21085	COG1011	Hydrolase
O1A01_RS21090	COG0527	aspartate kinase activity
O1A01_RS21100	COG0739	heme binding
O1A01_RS21110	COG0733	neurotransmitter:sodium symporter activity
O1A01_RS21115	COG1757	Na H antiporter
O1A01_RS21130	COG3377	Domain of unknown function (DUF1805)
O1A01_RS21135	COG0737	Belongs to the 5'-nucleotidase family
O1A01_RS21140	COG0730	response to heat
O1A01_RS21145	COG1801	Protein of unknown function DUF72
O1A01_RS21150	COG0719	Fe-S assembly protein
O1A01_RS21155	COG0822	iron-sulfur transferase activity
O1A01_RS21160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O1A01_RS21165	COG0719	Fe-S assembly protein
O1A01_RS21170	COG0396	ATPase activity
O1A01_RS21180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1A01_RS21185	COG1464	Belongs to the NlpA lipoprotein family
O1A01_RS21195	COG2011	ABC-type metal ion transport system permease component
O1A01_RS21200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1A01_RS21210	COG2814	Major facilitator Superfamily
O1A01_RS21215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_RS21220	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O1A01_RS21235	COG0509	glycine decarboxylation via glycine cleavage system
O1A01_RS21240	COG1393	Belongs to the ArsC family
O1A01_RS21245	COG1960	acyl-CoA dehydrogenase activity
O1A01_RS21250	COG0183	Belongs to the thiolase family
O1A01_RS21255	COG1024	Enoyl-CoA hydratase
O1A01_RS21255	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1A01_RS21280	COG5577	PFAM Coat F domain
O1A01_RS21295	COG1120	ATPase activity
O1A01_RS21300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1A01_RS21305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1A01_RS21310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O1A01_RS21315	COG0584	glycerophosphoryl diester phosphodiesterase
O1A01_RS21320	COG0737	Belongs to the 5'-nucleotidase family
O1A01_RS21330	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS21335	COG0750	zinc metalloprotease
O1A01_RS21355	COG1595	DNA-templated transcription, initiation
O1A01_RS21360	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS21360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS21365	COG1054	Belongs to the UPF0176 family
O1A01_RS21370	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_RS21375	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS21380	COG1937	Protein conserved in bacteria
O1A01_RS21385	COG0726	polysaccharide deacetylase
O1A01_RS21390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O1A01_RS21395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O1A01_RS21405	COG1063	alcohol dehydrogenase
O1A01_RS21415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_RS21415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1A01_RS21440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O1A01_RS21445	COG0557	exoribonuclease II activity
O1A01_RS21450	COG1647	Serine aminopeptidase, S33
O1A01_RS21460	COG1396	sequence-specific DNA binding
O1A01_RS21470	COG0681	Belongs to the peptidase S26 family
O1A01_RS21495	COG5002	protein histidine kinase activity
O1A01_RS21500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O1A01_RS21510	COG0148	phosphopyruvate hydratase activity
O1A01_RS21520	COG0149	triose-phosphate isomerase activity
O1A01_RS21530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O1A01_RS21545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
O1A01_RS21560	COG0740	serine-type endopeptidase activity
O1A01_RS21570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_RS21575	COG1481	regulation of sporulation
O1A01_RS21580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O1A01_RS21585	COG1660	Displays ATPase and GTPase activities
O1A01_RS21590	COG1051	belongs to the nudix hydrolase family
O1A01_RS21595	COG0492	ferredoxin-NADP+ reductase activity
O1A01_RS21600	COG0457	Tetratricopeptide repeat
O1A01_RS21605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O1A01_RS21605	COG0140	phosphoribosyl-ATP diphosphatase activity
O1A01_RS21610	COG0107	imidazoleglycerol-phosphate synthase activity
O1A01_RS21615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O1A01_RS21625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O1A01_RS21630	COG0131	Imidazoleglycerol-phosphate dehydratase
O1A01_RS21635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O1A01_RS21645	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
O1A01_RS21650	COG0110	maltose O-acetyltransferase activity
O1A01_RS21655	COG0546	phosphoglycolate phosphatase activity
O1A01_RS21660	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
O1A01_RS21675	COG1950	PFAM Membrane protein of
O1A01_RS21680	COG1983	PspC domain protein
O1A01_RS21685	COG3595	metallopeptidase activity
O1A01_RS21700	COG0840	transmembrane signaling receptor activity
O1A01_RS21725	COG2508	Transcriptional regulator
O1A01_RS21730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O1A01_RS21735	COG0556	nucleotide-excision repair
O1A01_RS21750	COG1595	DNA-templated transcription, initiation
O1A01_RS21755	COG4897	Protein conserved in bacteria
O1A01_RS21765	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
O1A01_RS21785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O1A01_RS21790	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
O1A01_RS21795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1A01_RS21800	COG3409	Peptidoglycan-binding domain 1 protein
O1A01_RS21800	COG0793	Belongs to the peptidase S41A family
O1A01_RS21805	COG0739	heme binding
O1A01_RS21810	COG2177	Part of the ABC transporter FtsEX involved in
O1A01_RS21815	COG2884	Cell division ATP-binding protein ftsE
O1A01_RS21830	COG1404	Belongs to the peptidase S8 family
O1A01_RS21840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O1A01_RS21855	COG0653	protein targeting
O1A01_RS21865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O1A01_RS21885	COG1516	flagellar protein fliS
O1A01_RS21890	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
O1A01_RS21905	COG4932	domain protein
O1A01_RS21905	COG5492	domain, Protein
O1A01_RS21910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1A01_RS21915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O1A01_RS21920	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
O1A01_RS21930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1A01_RS21935	COG1256	bacterial-type flagellum assembly
O1A01_RS21935	COG4786	Flagellar basal body rod
O1A01_RS21955	COG1040	competence protein
O1A01_RS21960	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
O1A01_RS21965	COG1307	EDD domain protein, DegV family
O1A01_RS21985	COG2197	response regulator
O1A01_RS21990	COG4585	Histidine kinase
O1A01_RS21995	COG1739	Uncharacterized protein family UPF0029
O1A01_RS22000	COG1316	TRANSCRIPTIONal
O1A01_RS22005	COG0438	transferase activity, transferring glycosyl groups
O1A01_RS22010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O1A01_RS22015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O1A01_RS22035	COG4464	protein tyrosine phosphatase activity
O1A01_RS22040	COG3764	Sortase (surface protein transpeptidase)
O1A01_RS22055	COG4715	Zinc finger, swim domain protein
O1A01_RS22060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1A01_RS22075	COG0629	single-stranded DNA binding
O1A01_RS22085	COG3764	Sortase (surface protein transpeptidase)
O1A01_RS22105	COG1316	TRANSCRIPTIONal
O1A01_RS22110	COG1227	inorganic diphosphatase activity
O1A01_RS22115	COG1215	transferase activity, transferring glycosyl groups
O1A01_RS22130	COG4193	domain, Protein
O1A01_RS22135	COG0463	Glycosyl transferase, family 2
O1A01_RS22150	COG0860	N-Acetylmuramoyl-L-alanine amidase
O1A01_RS22150	COG2247	cell wall binding repeat
O1A01_RS22170	COG1215	transferase activity, transferring glycosyl groups
O1A01_RS22175	COG0438	transferase activity, transferring glycosyl groups
O1A01_RS22180	COG1653	transport
O1A01_RS22185	COG0395	ABC-type sugar transport system, permease component
O1A01_RS22190	COG1175	transmembrane transport
O1A01_RS22200	COG1316	TRANSCRIPTIONal
O1A01_RS22205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1A01_RS22215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O1A01_RS22245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1A01_RS22250	COG1464	Belongs to the NlpA lipoprotein family
O1A01_RS22255	COG0371	Dehydrogenase
O1A01_RS22260	COG2031	fatty acid transporter
O1A01_RS22265	COG2962	Rard protein
O1A01_RS22290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O1A01_RS22320	COG2972	Histidine kinase
O1A01_RS22325	COG2182	Extracellular solute-binding protein
O1A01_RS22370	COG1404	Belongs to the peptidase S8 family
O1A01_RS22375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
O1A01_RS22380	COG0673	inositol 2-dehydrogenase activity
O1A01_RS22390	COG0366	Alpha amylase catalytic
O1A01_RS22395	COG1653	transport
O1A01_RS22400	COG4753	response regulator
O1A01_RS22400	COG2207	Transcriptional regulator
O1A01_RS22415	COG0395	ABC-type sugar transport system, permease component
O1A01_RS22420	COG1175	transmembrane transport
O1A01_RS22425	COG1653	transport
O1A01_RS22585	COG1505	serine-type exopeptidase activity
O1A01_RS22645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O1A01_RS22650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1A01_RS22655	COG1609	Transcriptional regulator
O1A01_RS22660	COG2706	6-phosphogluconolactonase activity
O1A01_RS22665	COG0346	lactoylglutathione lyase activity
O1A01_RS22675	COG3459	Glycosyltransferase 36 associated
O1A01_RS22685	COG3119	arylsulfatase activity
O1A01_RS22705	COG1132	(ABC) transporter
O1A01_RS22725	COG0395	ABC-type sugar transport system, permease component
O1A01_RS22730	COG1175	transmembrane transport
O1A01_RS22745	COG0395	ABC-type sugar transport system, permease component
O1A01_RS22765	COG1609	Transcriptional regulator
O1A01_RS22770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O1A01_RS22785	COG0363	glucosamine-6-phosphate deaminase activity
O1A01_RS22790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O1A01_RS22795	COG3142	Participates in the control of copper homeostasis
O1A01_RS22805	COG2188	Transcriptional regulator
O1A01_RS22810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1A01_RS22810	COG1263	PTS System
O1A01_RS22815	COG2190	(PTS) system
O1A01_RS22825	COG0561	phosphatase activity
O1A01_RS22840	COG1063	alcohol dehydrogenase
O1A01_RS22845	COG1172	Belongs to the binding-protein-dependent transport system permease family
O1A01_RS22850	COG1129	ABC transporter
O1A01_RS22855	COG1879	ABC-type sugar transport system periplasmic component
O1A01_RS22865	COG1129	ABC transporter
O1A01_RS22870	COG1473	amidohydrolase
O1A01_RS22890	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O1A01_RS22900	COG1028	Short-chain dehydrogenase reductase Sdr
O1A01_RS22905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1A01_RS22965	COG1131	(ABC) transporter
O1A01_RS22985	COG1757	Na H antiporter
O1A01_RS23025	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
O1A01_RS23030	COG1072	(Pantothenic acid kinase))
O1A01_RS23040	COG2801	Transposase and inactivated derivatives
O1A01_RS23050	COG5583	Uncharacterized small protein (DUF2292)
O1A01_RS23055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O1A01_RS23065	COG3973	AAA domain
O1A01_RS23075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
O1A01_RS23100	COG0561	phosphatase activity
O1A01_RS23140	COG1737	Transcriptional regulator
O1A01_RS23190	COG0457	Tetratricopeptide repeat
O1A01_RS23190	COG0463	Glycosyl transferase, family 2
O1A01_RS23220	COG2814	Major facilitator Superfamily
O1A01_RS23255	COG5002	protein histidine kinase activity
O1A01_RS23260	COG0745	RESPONSE REGULATOR receiver
O1A01_RS23265	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O1A01_RS23270	COG1131	(ABC) transporter
O1A01_RS23285	COG1929	Belongs to the glycerate kinase type-1 family
O1A01_RS23295	COG0383	alpha-mannosidase activity
O1A01_RS23300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1A01_RS23300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1A01_RS23300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1A01_RS23305	COG1737	Transcriptional regulator
O1A01_RS23310	COG1482	cell wall glycoprotein biosynthetic process
O1A01_RS23320	COG0024	Methionine aminopeptidase
O1A01_RS23340	COG0606	chelatase, subunit chli
O1A01_RS23375	COG3273	potassium ion transport
O1A01_RS23375	COG0471	metal ion transport
O1A01_RS23385	COG5001	Diguanylate cyclase
O1A01_RS23425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_RS23430	COG0785	Cytochrome C biogenesis protein
O1A01_RS23440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS23460	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS23465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS23465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS23480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS23480	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS23500	COG1937	Protein conserved in bacteria
O1A01_RS23510	COG0730	response to heat
O1A01_RS23515	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS23520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS23520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1A01_RS23530	COG2210	Belongs to the sulfur carrier protein TusA family
O1A01_RS23535	COG0425	Belongs to the sulfur carrier protein TusA family
O1A01_RS23535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS23540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1A01_RS23620	COG2801	Transposase and inactivated derivatives
O1A01_RS23645	COG0463	Glycosyl transferase, family 2
O1A01_RS23645	COG1216	Glycosyl transferase, family 2
O1A01_RS23680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O1A01_RS23685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O1A01_RS23690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O1A01_RS23700	COG1086	Polysaccharide biosynthesis protein
O1A01_RS23710	COG0489	protein tyrosine kinase activity
O1A01_RS23715	COG3944	biosynthesis protein
O1A01_RS23765	COG4786	Flagellar basal body rod
O1A01_RS23780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1A01_RS23785	COG0765	amino acid transport
O1A01_RS23790	COG1126	abc transporter atp-binding protein
O1A01_RS23800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1A01_RS23820	COG2323	membrane
O1A01_RS23830	COG2197	response regulator
O1A01_RS23835	COG4585	Histidine kinase
O1A01_RS23840	COG3239	Fatty acid desaturase
O1A01_RS23845	COG1511	domain protein
O1A01_RS23850	COG1309	transcriptional regulator
O1A01_RS23855	COG0702	epimerase
O1A01_RS23860	COG1393	Belongs to the ArsC family
O1A01_RS23880	COG2226	methyltransferase
O1A01_RS23885	COG1476	TRANSCRIPTIONal
O1A01_RS23895	COG2723	6-phospho-beta-galactosidase activity
O1A01_RS23900	COG1077	Cell shape determining protein MreB Mrl
O1A01_RS23905	COG1609	Transcriptional regulator
O1A01_RS23920	COG0604	alcohol dehydrogenase
O1A01_RS23990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1A01_RS23995	COG0395	ABC-type sugar transport system, permease component
O1A01_RS24020	COG0456	acetyltransferase
O1A01_RS24040	COG2153	protein acetylation
O1A01_RS24050	COG5002	protein histidine kinase activity
O1A01_RS24050	COG2176	DNA-directed DNA polymerase activity
O1A01_RS24065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1A01_RS24085	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
O1A01_RS24090	COG2059	Chromate
O1A01_RS24095	COG2059	Chromate
O1A01_RS24100	COG0405	Gamma-glutamyltransferase
O1A01_RS24105	COG3852	Histidine kinase
O1A01_RS24110	COG3852	Histidine kinase
O1A01_RS24115	COG0739	heme binding
O1A01_RS24135	COG2385	sporulation resulting in formation of a cellular spore
O1A01_RS24140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O1A01_RS24150	COG4836	Membrane
O1A01_RS24155	COG1007	ATP synthesis coupled electron transport
O1A01_RS24165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O1A01_RS24170	COG0713	ATP synthesis coupled electron transport
O1A01_RS24175	COG0839	Belongs to the complex I subunit 6 family
O1A01_RS24180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1A01_RS24185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O1A01_RS24195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1A01_RS24200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1A01_RS24210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O1A01_RS24215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O1A01_RS24220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O1A01_RS24225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O1A01_RS24230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O1A01_RS24235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O1A01_RS24240	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O1A01_RS24245	COG0356	it plays a direct role in the translocation of protons across the membrane
O1A01_RS24260	COG1404	Belongs to the peptidase S8 family
O1A01_RS24275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O1A01_RS24290	COG1595	DNA-templated transcription, initiation
O1A01_RS24300	COG0698	ribose 5-phosphate isomerase
O1A01_RS24305	COG5278	phosphoserine phosphatase activity
O1A01_RS24305	COG0840	transmembrane signaling receptor activity
O1A01_RS24310	COG0840	transmembrane signaling receptor activity
O1A01_RS24320	COG1971	Probably functions as a manganese efflux pump
O1A01_RS24325	COG0009	L-threonylcarbamoyladenylate synthase
O1A01_RS24340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O1A01_RS24375	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O1A01_RS24385	COG0697	spore germination
O1A01_RS24390	COG1435	thymidine kinase activity
O1A01_RS24400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O1A01_RS24405	COG1494	fructose-1,6-bisphosphatase
O1A01_RS24410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O1A01_RS24415	COG0191	fructose-bisphosphate aldolase activity
O1A01_RS24420	COG2204	response regulator
O1A01_RS24425	COG4821	SIS domain
O1A01_RS24430	COG0504	CTP synthase activity
O1A01_RS24435	COG3343	RNA polymerase activity
O1A01_RS24440	COG1703	isobutyryl-CoA mutase activity
O1A01_RS24440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1A01_RS24440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1A01_RS24445	COG3226	Transcriptional regulator
O1A01_RS24450	COG1960	acyl-CoA dehydrogenase activity
O1A01_RS24455	COG1960	acyl-CoA dehydrogenase activity
O1A01_RS24460	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1A01_RS24470	COG0183	Belongs to the thiolase family
O1A01_RS24475	COG0247	lactate metabolic process
O1A01_RS24475	COG2181	nitrate reductase activity
O1A01_RS24480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O1A01_RS24495	COG1595	DNA-templated transcription, initiation
O1A01_RS24515	COG0675	Transposase, IS605 OrfB family
O1A01_RS24520	COG0010	Belongs to the arginase family
O1A01_RS24525	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
O1A01_RS24530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1A01_RS24540	COG1994	Peptidase M50
O1A01_RS24550	COG0456	acetyltransferase
O1A01_RS24560	COG3465	dGTPase activity
O1A01_RS24565	COG1078	dGTPase activity
O1A01_RS24580	COG0095	Lipoate-protein ligase
O1A01_RS24585	COG0280	phosphate acetyltransferase
O1A01_RS24590	COG3253	May function as heme-dependent peroxidase
O1A01_RS24600	COG2363	Small membrane protein
O1A01_RS24605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
O1A01_RS24615	COG1984	allophanate hydrolase subunit 2
O1A01_RS24630	COG2322	membrane
O1A01_RS24650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O1A01_RS24655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O1A01_RS24675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O1A01_RS24685	COG0501	Belongs to the peptidase M48B family
O1A01_RS24700	COG0778	Nitroreductase
O1A01_RS24710	COG2031	fatty acid transporter
O1A01_RS24715	COG0561	phosphatase activity
O1A01_RS24725	COG3314	Sporulation integral membrane protein YlbJ
O1A01_RS24750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O1A01_RS24755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O1A01_RS24755	COG0551	DNA topoisomerase type I activity
O1A01_RS24760	COG0488	(ABC) transporter
O1A01_RS24790	COG1595	DNA-templated transcription, initiation
O1A01_RS24810	COG3842	ATPase activity
O1A01_RS24820	COG1840	ABC-type Fe3 transport system, periplasmic component
O1A01_RS24825	COG1794	racemase activity, acting on amino acids and derivatives
O1A01_RS24835	COG0367	asparagine synthase
O1A01_RS24840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O1A01_RS24845	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O1A01_RS24850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O1A01_RS24865	COG4187	Peptidase family M20/M25/M40
O1A01_RS24870	COG1079	Belongs to the binding-protein-dependent transport system permease family
O1A01_RS24875	COG4603	Belongs to the binding-protein-dependent transport system permease family
O1A01_RS24880	COG3845	ABC transporter
O1A01_RS24885	COG1744	ABC transporter substrate-binding protein PnrA-like
O1A01_RS24890	COG1959	2 iron, 2 sulfur cluster binding
O1A01_RS24900	COG2814	Major facilitator Superfamily
O1A01_RS24915	COG1187	pseudouridine synthase activity
O1A01_RS24920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1A01_RS24935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1A01_RS24960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1A01_RS24965	COG0561	phosphatase activity
O1A01_RS24970	COG0798	PFAM Bile acid sodium symporter
O1A01_RS25000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O1A01_RS25020	COG4191	Histidine kinase
O1A01_RS25025	COG1966	Carbon starvation protein
O1A01_RS25055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1A01_RS25060	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O1A01_RS25070	COG4863	YycH protein
O1A01_RS25075	COG5002	protein histidine kinase activity
O1A01_RS25080	COG0745	RESPONSE REGULATOR receiver
O1A01_RS25085	COG0739	heme binding
O1A01_RS25085	COG0741	lytic transglycosylase activity
O1A01_RS25085	COG1196	nuclear chromosome segregation
O1A01_RS25115	COG0305	Participates in initiation and elongation during chromosome replication
O1A01_RS25120	COG0359	binds to the 23S rRNA
O1A01_RS25125	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
O1A01_RS25135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O1A01_RS25155	COG4974	Belongs to the 'phage' integrase family
O1A01_RS25165	COG1404	Belongs to the peptidase S8 family
O1A01_RS25185	COG1396	sequence-specific DNA binding
O1A01_RS25195	COG1401	restriction endodeoxyribonuclease activity
O1A01_RS25220	COG0653	protein targeting
O1A01_RS25235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O1A01_RS25245	COG0360	Binds together with S18 to 16S ribosomal RNA
O1A01_RS25250	COG0012	GTP binding
O1A01_RS25255	COG4481	Protein conserved in bacteria
O1A01_RS25260	COG3949	Membrane
O1A01_RS25275	COG1475	DNA binding
O1A01_RS25280	COG1192	Involved in chromosome partitioning
O1A01_RS25285	COG1475	DNA binding
O1A01_RS25290	COG0357	Ribosomal RNA small subunit methyltransferase G
O1A01_RS25295	COG0445	tRNA wobble uridine modification
O1A01_RS25300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O1A01_RS25305	COG1847	R3H domain protein
O1A01_RS25320	COG0230	Belongs to the bacterial ribosomal protein bL34 family