locus-tag	class	description
S6FBBBH3_RS00010	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S6FBBBH3_RS00030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S6FBBBH3_RS00035	COG2011	ABC-type metal ion transport system permease component
S6FBBBH3_RS00040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S6FBBBH3_RS00045	COG1968	undecaprenyl-diphosphatase activity
S6FBBBH3_RS00050	COG3012	SEC-C Motif Domain Protein
S6FBBBH3_RS00050	COG3318	Belongs to the UPF0149 family
S6FBBBH3_RS00055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S6FBBBH3_RS00055	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
S6FBBBH3_RS00060	COG0488	(ABC) transporter
S6FBBBH3_RS00075	COG0589	response to stress
S6FBBBH3_RS00080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S6FBBBH3_RS00095	COG0315	cyclic pyranopterin monophosphate synthase activity
S6FBBBH3_RS00105	COG0492	ferredoxin-NADP+ reductase activity
S6FBBBH3_RS00110	COG0489	protein tyrosine kinase activity
S6FBBBH3_RS00115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S6FBBBH3_RS00115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S6FBBBH3_RS00120	COG0659	secondary active sulfate transmembrane transporter activity
S6FBBBH3_RS00125	COG1464	Belongs to the NlpA lipoprotein family
S6FBBBH3_RS00150	COG0823	Involved in the tonB-independent uptake of proteins
S6FBBBH3_RS00165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S6FBBBH3_RS00180	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
S6FBBBH3_RS00185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S6FBBBH3_RS00190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S6FBBBH3_RS00205	COG0751	glycine-tRNA ligase activity
S6FBBBH3_RS00210	COG0752	glycyl-tRNA synthetase alpha subunit
S6FBBBH3_RS00215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
S6FBBBH3_RS00220	COG4535	Mg2 and Co2 transporter CorC
S6FBBBH3_RS00225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S6FBBBH3_RS00230	COG1702	phosphate starvation-inducible protein PhoH
S6FBBBH3_RS00235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S6FBBBH3_RS00245	COG0351	phosphomethylpyrimidine kinase
S6FBBBH3_RS00255	COG0859	PFAM glycosyl transferase family 9
S6FBBBH3_RS00270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
S6FBBBH3_RS00275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S6FBBBH3_RS00280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
S6FBBBH3_RS00285	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S6FBBBH3_RS00290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S6FBBBH3_RS00295	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S6FBBBH3_RS00305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S6FBBBH3_RS00310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S6FBBBH3_RS00325	COG1752	Esterase of the alpha-beta hydrolase superfamily
S6FBBBH3_RS00330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S6FBBBH3_RS00345	COG2814	Major facilitator Superfamily
S6FBBBH3_RS00350	COG0629	single-stranded DNA binding
S6FBBBH3_RS00355	COG0577	efflux transmembrane transporter activity
S6FBBBH3_RS00355	COG1136	(ABC) transporter
S6FBBBH3_RS00360	COG0577	efflux transmembrane transporter activity
S6FBBBH3_RS00360	COG1136	(ABC) transporter
S6FBBBH3_RS00375	COG0745	RESPONSE REGULATOR receiver
S6FBBBH3_RS00380	COG2205	protein histidine kinase activity
S6FBBBH3_RS00385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S6FBBBH3_RS00400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S6FBBBH3_RS00420	COG0235	Class ii aldolase
S6FBBBH3_RS00425	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S6FBBBH3_RS00430	COG0045	succinate-CoA ligase (ADP-forming) activity
S6FBBBH3_RS00430	COG1042	CoA-binding domain protein
S6FBBBH3_RS00430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S6FBBBH3_RS00435	COG1024	Enoyl-CoA hydratase
S6FBBBH3_RS00445	COG0765	amino acid transport
S6FBBBH3_RS00450	COG0765	amino acid transport
S6FBBBH3_RS00455	COG1126	abc transporter atp-binding protein
S6FBBBH3_RS00465	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
S6FBBBH3_RS00480	COG1137	ATPase activity
S6FBBBH3_RS00485	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S6FBBBH3_RS00490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S6FBBBH3_RS00500	COG1194	a g-specific adenine glycosylase
S6FBBBH3_RS00510	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
S6FBBBH3_RS00515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S6FBBBH3_RS00525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S6FBBBH3_RS00530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S6FBBBH3_RS00545	COG0012	GTP binding
S6FBBBH3_RS00565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S6FBBBH3_RS00570	COG0742	ribosomal rna small subunit methyltransferase
S6FBBBH3_RS00580	COG0248	Ppx GppA phosphatase
S6FBBBH3_RS00585	COG2884	Cell division ATP-binding protein ftsE
S6FBBBH3_RS00600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S6FBBBH3_RS00605	COG2197	response regulator
S6FBBBH3_RS00610	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
S6FBBBH3_RS00615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S6FBBBH3_RS00620	COG4942	peptidase
S6FBBBH3_RS00625	COG0793	Belongs to the peptidase S41A family
S6FBBBH3_RS00630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S6FBBBH3_RS00635	COG0616	signal peptide processing
S6FBBBH3_RS00650	COG0523	cobalamin synthesis protein
S6FBBBH3_RS00660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S6FBBBH3_RS00665	COG1560	Kdo2-lipid A biosynthetic process
S6FBBBH3_RS00675	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S6FBBBH3_RS00685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
S6FBBBH3_RS00690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S6FBBBH3_RS00695	COG0741	lytic transglycosylase activity
S6FBBBH3_RS00700	COG0617	tRNA 3'-terminal CCA addition
S6FBBBH3_RS00720	COG0516	GMP reductase activity
S6FBBBH3_RS00720	COG0517	IMP dehydrogenase activity
S6FBBBH3_RS00725	COG2326	polyphosphate kinase activity
S6FBBBH3_RS00740	COG0488	(ABC) transporter
S6FBBBH3_RS00745	COG1022	Amp-dependent synthetase and ligase
S6FBBBH3_RS00750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S6FBBBH3_RS00755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
S6FBBBH3_RS00755	COG4624	Iron only hydrogenase large subunit, C-terminal domain
S6FBBBH3_RS00760	COG4624	Iron only hydrogenase large subunit, C-terminal domain
S6FBBBH3_RS00775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S6FBBBH3_RS00780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
S6FBBBH3_RS00785	COG2233	PERMEase
S6FBBBH3_RS00790	COG2183	response to ionizing radiation
S6FBBBH3_RS00800	COG0765	amino acid transport
S6FBBBH3_RS00805	COG4597	amino acid ABC transporter
S6FBBBH3_RS00810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S6FBBBH3_RS00815	COG1253	flavin adenine dinucleotide binding
S6FBBBH3_RS00830	COG0242	peptide deformylase activity
S6FBBBH3_RS00840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S6FBBBH3_RS00845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S6FBBBH3_RS00845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S6FBBBH3_RS00855	COG5000	phosphorelay sensor kinase activity
S6FBBBH3_RS00860	COG2204	response regulator
S6FBBBH3_RS00870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S6FBBBH3_RS00885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S6FBBBH3_RS00890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S6FBBBH3_RS00900	COG2211	Major facilitator Superfamily
S6FBBBH3_RS00910	COG0708	Exodeoxyribonuclease III
S6FBBBH3_RS00915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S6FBBBH3_RS00920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S6FBBBH3_RS00930	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S6FBBBH3_RS00935	COG1077	Cell shape determining protein MreB Mrl
S6FBBBH3_RS00950	COG0768	penicillin binding
S6FBBBH3_RS00955	COG0772	Belongs to the SEDS family
S6FBBBH3_RS00985	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S6FBBBH3_RS01000	COG2921	Belongs to the UPF0250 family
S6FBBBH3_RS01005	COG1575	Belongs to the MenA family. Type 1 subfamily
S6FBBBH3_RS01010	COG2823	Periplasmic or secreted lipoprotein
S6FBBBH3_RS01040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S6FBBBH3_RS01045	COG0230	Belongs to the bacterial ribosomal protein bL34 family
S6FBBBH3_RS01055	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S6FBBBH3_RS01070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S6FBBBH3_RS01075	COG0445	tRNA wobble uridine modification
S6FBBBH3_RS01080	COG0357	Ribosomal RNA small subunit methyltransferase G
S6FBBBH3_RS01090	COG1192	Involved in chromosome partitioning
S6FBBBH3_RS01095	COG1475	DNA binding
S6FBBBH3_RS01105	COG0356	it plays a direct role in the translocation of protons across the membrane
S6FBBBH3_RS01120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S6FBBBH3_RS01125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S6FBBBH3_RS01130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S6FBBBH3_RS01135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S6FBBBH3_RS01140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S6FBBBH3_RS01150	COG1872	DUF167
S6FBBBH3_RS01155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S6FBBBH3_RS01160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S6FBBBH3_RS01175	COG2226	methyltransferase
S6FBBBH3_RS01190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S6FBBBH3_RS01225	COG1301	dicarboxylic acid transport
S6FBBBH3_RS01230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S6FBBBH3_RS01235	COG0642	Histidine kinase
S6FBBBH3_RS01260	COG2346	COG2346, Truncated hemoglobins
S6FBBBH3_RS01270	COG1294	oxidase, subunit
S6FBBBH3_RS01290	COG2267	carboxylic ester hydrolase activity
S6FBBBH3_RS01310	COG0674	pyruvate-flavodoxin oxidoreductase activity
S6FBBBH3_RS01315	COG1013	pyruvate-flavodoxin oxidoreductase activity
S6FBBBH3_RS01325	COG3850	Histidine kinase
S6FBBBH3_RS01330	COG2197	response regulator
S6FBBBH3_RS01340	COG0348	domain, Protein
S6FBBBH3_RS01345	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS01350	COG0243	molybdopterin cofactor binding
S6FBBBH3_RS01370	COG0514	ATP-dependent DNA helicase (RecQ)
S6FBBBH3_RS01375	COG4221	oxidoreductase activity
S6FBBBH3_RS01380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S6FBBBH3_RS01390	COG0018	arginyl-trna synthetase
S6FBBBH3_RS01395	COG1469	GTP cyclohydrolase I activity
S6FBBBH3_RS01425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S6FBBBH3_RS01435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S6FBBBH3_RS01450	COG0081	regulation of translation
S6FBBBH3_RS01455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S6FBBBH3_RS01465	COG0085	RNA polymerase activity
S6FBBBH3_RS01470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S6FBBBH3_RS01475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S6FBBBH3_RS01480	COG0049	tRNA binding
S6FBBBH3_RS01485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S6FBBBH3_RS01490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S6FBBBH3_RS01495	COG0051	transcription antitermination factor activity, RNA binding
S6FBBBH3_RS01500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S6FBBBH3_RS01505	COG0088	Forms part of the polypeptide exit tunnel
S6FBBBH3_RS01510	COG0089	rRNA binding
S6FBBBH3_RS01515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S6FBBBH3_RS01520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S6FBBBH3_RS01525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S6FBBBH3_RS01530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S6FBBBH3_RS01535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S6FBBBH3_RS01540	COG0255	Belongs to the universal ribosomal protein uL29 family
S6FBBBH3_RS01545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S6FBBBH3_RS01550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S6FBBBH3_RS01555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S6FBBBH3_RS01560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S6FBBBH3_RS01565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S6FBBBH3_RS01570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S6FBBBH3_RS01575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S6FBBBH3_RS01580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S6FBBBH3_RS01585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S6FBBBH3_RS01590	COG1841	ribosomal large subunit assembly
S6FBBBH3_RS01595	COG0200	Binds to the 23S rRNA
S6FBBBH3_RS01600	COG0201	protein transport
S6FBBBH3_RS01605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S6FBBBH3_RS01610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S6FBBBH3_RS01615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S6FBBBH3_RS01620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S6FBBBH3_RS01625	COG0202	RNA polymerase activity
S6FBBBH3_RS01630	COG0203	ribosomal protein L17
S6FBBBH3_RS01635	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S6FBBBH3_RS01645	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S6FBBBH3_RS01650	COG0516	GMP reductase activity
S6FBBBH3_RS01665	COG1965	Belongs to the frataxin family
S6FBBBH3_RS01680	COG1127	ABC transporter
S6FBBBH3_RS01685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
S6FBBBH3_RS01690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
S6FBBBH3_RS01695	COG2853	Lipoprotein
S6FBBBH3_RS01710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S6FBBBH3_RS01720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S6FBBBH3_RS01725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S6FBBBH3_RS01730	COG0805	protein transport
S6FBBBH3_RS01735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S6FBBBH3_RS01740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S6FBBBH3_RS01745	COG0625	glutathione transferase activity
S6FBBBH3_RS01760	COG2890	protein-(glutamine-N5) methyltransferase activity
S6FBBBH3_RS01765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S6FBBBH3_RS01770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S6FBBBH3_RS01780	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S6FBBBH3_RS01795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S6FBBBH3_RS01805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S6FBBBH3_RS01810	COG0546	phosphoglycolate phosphatase activity
S6FBBBH3_RS01820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S6FBBBH3_RS01870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S6FBBBH3_RS01915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S6FBBBH3_RS01920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S6FBBBH3_RS01925	COG2095	MarC family integral membrane protein
S6FBBBH3_RS01930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S6FBBBH3_RS01935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S6FBBBH3_RS01945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
S6FBBBH3_RS01950	COG0739	heme binding
S6FBBBH3_RS01960	COG1490	D-aminoacyl-tRNA deacylase activity
S6FBBBH3_RS01975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S6FBBBH3_RS01980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S6FBBBH3_RS01980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S6FBBBH3_RS01990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S6FBBBH3_RS01995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S6FBBBH3_RS02005	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S6FBBBH3_RS02010	COG1058	Belongs to the CinA family
S6FBBBH3_RS02010	COG1546	Belongs to the CinA family
S6FBBBH3_RS02015	COG1253	flavin adenine dinucleotide binding
S6FBBBH3_RS02025	COG0284	orotidine-5'-phosphate decarboxylase activity
S6FBBBH3_RS02040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S6FBBBH3_RS02045	COG2027	D-alanyl-D-alanine carboxypeptidase
S6FBBBH3_RS02055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S6FBBBH3_RS02070	COG2001	Belongs to the MraZ family
S6FBBBH3_RS02075	COG0275	rRNA processing
S6FBBBH3_RS02090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S6FBBBH3_RS02095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S6FBBBH3_RS02100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S6FBBBH3_RS02105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S6FBBBH3_RS02115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S6FBBBH3_RS02125	COG1181	Belongs to the D-alanine--D-alanine ligase family
S6FBBBH3_RS02130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S6FBBBH3_RS02135	COG0849	cell division
S6FBBBH3_RS02155	COG0653	protein targeting
S6FBBBH3_RS02165	COG0494	nUDIX hydrolase
S6FBBBH3_RS02170	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
S6FBBBH3_RS02180	COG0237	dephospho-CoA kinase activity
S6FBBBH3_RS02190	COG0142	geranyltranstransferase activity
S6FBBBH3_RS02200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S6FBBBH3_RS02205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S6FBBBH3_RS02210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S6FBBBH3_RS02215	COG0442	prolyl-tRNA aminoacylation
S6FBBBH3_RS02230	COG0811	peptide transport
S6FBBBH3_RS02235	COG0824	Thioesterase
S6FBBBH3_RS02245	COG2255	four-way junction helicase activity
S6FBBBH3_RS02250	COG0632	four-way junction helicase activity
S6FBBBH3_RS02255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
S6FBBBH3_RS02260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S6FBBBH3_RS02265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S6FBBBH3_RS02280	COG0762	integral membrane protein
S6FBBBH3_RS02295	COG2264	protein methyltransferase activity
S6FBBBH3_RS02300	COG0439	Biotin carboxylase
S6FBBBH3_RS02305	COG0511	ligase activity, forming carbon-carbon bonds
S6FBBBH3_RS02315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S6FBBBH3_RS02320	COG3150	esterase
S6FBBBH3_RS02325	COG0557	exoribonuclease II activity
S6FBBBH3_RS02330	COG2239	Acts as a magnesium transporter
S6FBBBH3_RS02340	COG0739	heme binding
S6FBBBH3_RS02340	COG1196	nuclear chromosome segregation
S6FBBBH3_RS02340	COG0741	lytic transglycosylase activity
S6FBBBH3_RS02350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S6FBBBH3_RS02355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S6FBBBH3_RS02360	COG0126	phosphoglycerate kinase activity
S6FBBBH3_RS02365	COG2195	Cleaves the N-terminal amino acid of tripeptides
S6FBBBH3_RS02370	COG1442	glycosyl transferase family 8
S6FBBBH3_RS02370	COG1216	Glycosyl transferase, family 2
S6FBBBH3_RS02380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
S6FBBBH3_RS02385	COG0586	Pfam SNARE associated Golgi protein
S6FBBBH3_RS02390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S6FBBBH3_RS02395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S6FBBBH3_RS02400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S6FBBBH3_RS02415	COG0617	tRNA 3'-terminal CCA addition
S6FBBBH3_RS02420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S6FBBBH3_RS02435	COG0521	Mo-molybdopterin cofactor biosynthetic process
S6FBBBH3_RS02440	COG3028	Belongs to the UPF0307 family
S6FBBBH3_RS02445	COG0312	modulator of DNA gyrase
S6FBBBH3_RS02450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S6FBBBH3_RS02455	COG0343	queuine tRNA-ribosyltransferase activity
S6FBBBH3_RS02460	COG1862	Preprotein translocase
S6FBBBH3_RS02465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S6FBBBH3_RS02470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S6FBBBH3_RS02495	COG2194	sulfuric ester hydrolase activity
S6FBBBH3_RS02500	COG0352	thiamine-phosphate diphosphorylase activity
S6FBBBH3_RS02505	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S6FBBBH3_RS02515	COG0730	response to heat
S6FBBBH3_RS02525	COG1216	Glycosyl transferase, family 2
S6FBBBH3_RS02540	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S6FBBBH3_RS02555	COG0328	RNA-DNA hybrid ribonuclease activity
S6FBBBH3_RS02580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S6FBBBH3_RS02590	COG1132	(ABC) transporter
S6FBBBH3_RS02595	COG1760	l-serine dehydratase
S6FBBBH3_RS02610	COG2925	Exonuclease
S6FBBBH3_RS02620	COG2084	Dehydrogenase
S6FBBBH3_RS02625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S6FBBBH3_RS02635	COG1477	protein flavinylation
S6FBBBH3_RS02655	COG0497	DNA recombination
S6FBBBH3_RS02660	COG1115	amino acid carrier protein
S6FBBBH3_RS02665	COG0165	Argininosuccinate lyase
S6FBBBH3_RS02690	COG0525	valine-tRNA ligase activity
S6FBBBH3_RS02710	COG3976	FMN-binding domain protein
S6FBBBH3_RS02710	COG1053	succinate dehydrogenase
S6FBBBH3_RS02720	COG1053	succinate dehydrogenase
S6FBBBH3_RS02745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S6FBBBH3_RS02750	COG1758	RNA polymerase activity
S6FBBBH3_RS02755	COG0194	GDP metabolic process
S6FBBBH3_RS02760	COG1561	YicC-like family, N-terminal region
S6FBBBH3_RS02770	COG1053	succinate dehydrogenase
S6FBBBH3_RS02775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S6FBBBH3_RS02780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S6FBBBH3_RS02785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S6FBBBH3_RS02790	COG0174	glutamine synthetase
S6FBBBH3_RS02795	COG3852	Histidine kinase
S6FBBBH3_RS02800	COG2204	response regulator
S6FBBBH3_RS02810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S6FBBBH3_RS02840	COG0708	Exodeoxyribonuclease III
S6FBBBH3_RS02850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S6FBBBH3_RS02855	COG4566	intracellular signal transduction
S6FBBBH3_RS02870	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
S6FBBBH3_RS02875	COG1643	Atp-dependent helicase
S6FBBBH3_RS02885	COG2181	nitrate reductase activity
S6FBBBH3_RS02885	COG0247	lactate metabolic process
S6FBBBH3_RS02895	COG0167	dihydroorotate dehydrogenase activity
S6FBBBH3_RS02965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S6FBBBH3_RS02970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S6FBBBH3_RS02980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S6FBBBH3_RS02985	COG1187	pseudouridine synthase activity
S6FBBBH3_RS02990	COG0779	Required for maturation of 30S ribosomal subunits
S6FBBBH3_RS02995	COG2251	uridine kinase activity
S6FBBBH3_RS02995	COG0195	Participates in both transcription termination and antitermination
S6FBBBH3_RS03000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S6FBBBH3_RS03005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S6FBBBH3_RS03015	COG1217	gtp-binding protein TYPA
S6FBBBH3_RS03020	COG3012	SEC-C Motif Domain Protein
S6FBBBH3_RS03035	COG0165	Argininosuccinate lyase
S6FBBBH3_RS03040	COG3069	C4-dicarboxylate transmembrane transporter activity
S6FBBBH3_RS03050	COG0277	FAD linked oxidase domain protein
S6FBBBH3_RS03055	COG0563	adenylate kinase activity
S6FBBBH3_RS03060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
S6FBBBH3_RS03070	COG1663	tetraacyldisaccharide 4'-kinase activity
S6FBBBH3_RS03075	COG1570	exodeoxyribonuclease VII activity
S6FBBBH3_RS03095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S6FBBBH3_RS03100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S6FBBBH3_RS03105	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S6FBBBH3_RS03110	COG0196	riboflavin kinase activity
S6FBBBH3_RS03115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S6FBBBH3_RS03120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S6FBBBH3_RS03120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S6FBBBH3_RS03130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S6FBBBH3_RS03135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S6FBBBH3_RS03140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S6FBBBH3_RS03145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S6FBBBH3_RS03150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S6FBBBH3_RS03155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S6FBBBH3_RS03160	COG1610	YqeY-like protein
S6FBBBH3_RS03170	COG1114	Component of the transport system for branched-chain amino acids
S6FBBBH3_RS03195	COG0513	Belongs to the DEAD box helicase family
S6FBBBH3_RS03200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S6FBBBH3_RS03200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S6FBBBH3_RS03215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S6FBBBH3_RS03230	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S6FBBBH3_RS03240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S6FBBBH3_RS03245	COG1653	transport
S6FBBBH3_RS03250	COG1175	transmembrane transport
S6FBBBH3_RS03255	COG0395	ABC-type sugar transport system, permease component
S6FBBBH3_RS03265	COG1238	metal cluster binding
S6FBBBH3_RS03280	COG0228	four-way junction DNA binding
S6FBBBH3_RS03285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S6FBBBH3_RS03290	COG0336	Belongs to the RNA methyltransferase TrmD family
S6FBBBH3_RS03295	COG0335	large ribosomal subunit rRNA binding
S6FBBBH3_RS03310	COG1017	nitric oxide dioxygenase activity
S6FBBBH3_RS03310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S6FBBBH3_RS03315	COG2032	superoxide dismutase activity
S6FBBBH3_RS03320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S6FBBBH3_RS03335	COG0495	leucyl-tRNA aminoacylation
S6FBBBH3_RS03340	COG0210	DNA helicase
S6FBBBH3_RS03350	COG3069	C4-dicarboxylate transmembrane transporter activity
S6FBBBH3_RS03365	COG0252	asparaginase activity
S6FBBBH3_RS03370	COG0137	argininosuccinate synthase activity
S6FBBBH3_RS03375	COG1230	cation diffusion facilitator family transporter
S6FBBBH3_RS03380	COG0504	CTP synthase activity
S6FBBBH3_RS03385	COG2877	3-deoxy-8-phosphooctulonate synthase activity
S6FBBBH3_RS03390	COG0148	phosphopyruvate hydratase activity
S6FBBBH3_RS03395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S6FBBBH3_RS03400	COG0642	Histidine kinase
S6FBBBH3_RS03435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S6FBBBH3_RS03445	COG0613	PHP domain protein
S6FBBBH3_RS03450	COG1994	Peptidase M50
S6FBBBH3_RS03460	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
S6FBBBH3_RS03480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S6FBBBH3_RS03485	COG2814	Major facilitator Superfamily
S6FBBBH3_RS03495	COG0564	pseudouridine synthase activity
S6FBBBH3_RS03505	COG1530	ribonuclease E activity
S6FBBBH3_RS03555	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS03575	COG1301	dicarboxylic acid transport
S6FBBBH3_RS03595	COG3976	FMN-binding domain protein
S6FBBBH3_RS03595	COG1053	succinate dehydrogenase
S6FBBBH3_RS03610	COG3976	FMN-binding domain protein
S6FBBBH3_RS03610	COG1053	succinate dehydrogenase
S6FBBBH3_RS03625	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
S6FBBBH3_RS03630	COG0165	Argininosuccinate lyase
S6FBBBH3_RS03650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S6FBBBH3_RS03655	COG0420	3'-5' exonuclease activity
S6FBBBH3_RS03660	COG0419	ATPase involved in DNA repair
S6FBBBH3_RS03670	COG0477	Major facilitator Superfamily
S6FBBBH3_RS03675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S6FBBBH3_RS03690	COG0667	Aldo Keto reductase
S6FBBBH3_RS03710	COG4953	penicillin-binding protein 1C
S6FBBBH3_RS03715	COG0114	fumarate hydratase activity
S6FBBBH3_RS03740	COG0424	maF-like protein
S6FBBBH3_RS03750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S6FBBBH3_RS03755	COG1114	Component of the transport system for branched-chain amino acids
S6FBBBH3_RS03760	COG2814	Major facilitator Superfamily
S6FBBBH3_RS03780	COG3604	Transcriptional regulator
S6FBBBH3_RS03785	COG3976	FMN-binding domain protein
S6FBBBH3_RS03785	COG1053	succinate dehydrogenase
S6FBBBH3_RS03795	COG2986	histidine ammonia-lyase
S6FBBBH3_RS03805	COG2862	Uncharacterized protein family, UPF0114
S6FBBBH3_RS03810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S6FBBBH3_RS03810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S6FBBBH3_RS03830	COG1214	PFAM Peptidase M22, glycoprotease
S6FBBBH3_RS03835	COG0456	acetyltransferase
S6FBBBH3_RS03850	COG4145	pantothenate transmembrane transporter activity
S6FBBBH3_RS03860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S6FBBBH3_RS03875	COG0318	PFAM AMP-dependent synthetase and ligase
S6FBBBH3_RS03880	COG0484	heat shock protein binding
S6FBBBH3_RS03890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S6FBBBH3_RS03895	COG2878	Part of a membrane complex involved in electron transport
S6FBBBH3_RS03900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S6FBBBH3_RS03905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
S6FBBBH3_RS03930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S6FBBBH3_RS03930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S6FBBBH3_RS03990	COG1722	exodeoxyribonuclease VII activity
S6FBBBH3_RS03995	COG0142	geranyltranstransferase activity
S6FBBBH3_RS04000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S6FBBBH3_RS04005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S6FBBBH3_RS04010	COG0268	Binds directly to 16S ribosomal RNA
S6FBBBH3_RS04015	COG0728	peptidoglycan biosynthetic process
S6FBBBH3_RS04030	COG2249	NAD(P)H dehydrogenase (quinone) activity
S6FBBBH3_RS04060	COG0488	(ABC) transporter
S6FBBBH3_RS04065	COG2890	protein-(glutamine-N5) methyltransferase activity
S6FBBBH3_RS04080	COG0493	'glutamate synthase
S6FBBBH3_RS04080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
S6FBBBH3_RS04090	COG3381	protein complex oligomerization
S6FBBBH3_RS04100	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS04115	COG0848	biopolymer transport protein
S6FBBBH3_RS04120	COG0811	peptide transport
S6FBBBH3_RS04125	COG4771	TonB-dependent receptor
S6FBBBH3_RS04130	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S6FBBBH3_RS04135	COG4605	iron ion homeostasis
S6FBBBH3_RS04140	COG4604	ABC transporter, ATP-binding protein
S6FBBBH3_RS04150	COG4607	ABC-type enterochelin transport system periplasmic component
S6FBBBH3_RS04155	COG1196	nuclear chromosome segregation
S6FBBBH3_RS04165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S6FBBBH3_RS04175	COG0242	peptide deformylase activity
S6FBBBH3_RS04185	COG2119	membrane
S6FBBBH3_RS04195	COG1309	transcriptional regulator
S6FBBBH3_RS04210	COG0483	inositol monophosphate 1-phosphatase activity
S6FBBBH3_RS04220	COG0747	negative chemotaxis
S6FBBBH3_RS04230	COG0601	transmembrane transport
S6FBBBH3_RS04235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S6FBBBH3_RS04245	COG0560	Phosphoserine phosphatase
S6FBBBH3_RS04245	COG3830	Belongs to the UPF0237 family
S6FBBBH3_RS04255	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
S6FBBBH3_RS04270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S6FBBBH3_RS04275	COG0129	dihydroxy-acid dehydratase activity
S6FBBBH3_RS04300	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
S6FBBBH3_RS04310	COG0052	Belongs to the universal ribosomal protein uS2 family
S6FBBBH3_RS04315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S6FBBBH3_RS04320	COG0528	UMP kinase activity
S6FBBBH3_RS04340	COG1739	Uncharacterized protein family UPF0029
S6FBBBH3_RS04345	COG1408	metallophosphoesterase
S6FBBBH3_RS04350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S6FBBBH3_RS04370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S6FBBBH3_RS04375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S6FBBBH3_RS04395	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S6FBBBH3_RS04400	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S6FBBBH3_RS04410	COG1979	alcohol dehydrogenase
S6FBBBH3_RS04420	COG4191	Histidine kinase
S6FBBBH3_RS04430	COG0431	NADPH-dependent FMN reductase
S6FBBBH3_RS04430	COG1053	succinate dehydrogenase
S6FBBBH3_RS04430	COG3976	FMN-binding domain protein
S6FBBBH3_RS04440	COG4191	Histidine kinase
S6FBBBH3_RS04450	COG0243	molybdopterin cofactor binding
S6FBBBH3_RS04455	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS04460	COG1115	amino acid carrier protein
S6FBBBH3_RS04465	COG0583	DNA-binding transcription factor activity
S6FBBBH3_RS04485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S6FBBBH3_RS04490	COG1757	Na H antiporter
S6FBBBH3_RS04510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S6FBBBH3_RS04515	COG0601	transmembrane transport
S6FBBBH3_RS04535	COG3069	C4-dicarboxylate transmembrane transporter activity
S6FBBBH3_RS04540	COG1473	amidohydrolase
S6FBBBH3_RS04550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS04555	COG0431	NADPH-dependent FMN reductase
S6FBBBH3_RS04555	COG3976	FMN-binding domain protein
S6FBBBH3_RS04555	COG1053	succinate dehydrogenase
S6FBBBH3_RS04590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS04600	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS04615	COG0710	3-dehydroquinate dehydratase activity
S6FBBBH3_RS04625	COG4566	intracellular signal transduction
S6FBBBH3_RS04630	COG1053	succinate dehydrogenase
S6FBBBH3_RS04635	COG1053	succinate dehydrogenase
S6FBBBH3_RS04645	COG0252	asparaginase activity
S6FBBBH3_RS04675	COG4651	solute:proton antiporter activity
S6FBBBH3_RS04675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S6FBBBH3_RS04690	COG1053	succinate dehydrogenase
S6FBBBH3_RS04715	COG1129	ABC transporter
S6FBBBH3_RS04735	COG1129	ABC transporter
S6FBBBH3_RS04795	COG2205	protein histidine kinase activity
S6FBBBH3_RS04800	COG4566	intracellular signal transduction
S6FBBBH3_RS04805	COG1053	succinate dehydrogenase
S6FBBBH3_RS04810	COG1309	transcriptional regulator
S6FBBBH3_RS04815	COG0675	Transposase, IS605 OrfB family
S6FBBBH3_RS04865	COG0729	surface antigen
S6FBBBH3_RS04875	COG1757	Na H antiporter
S6FBBBH3_RS04885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S6FBBBH3_RS04885	COG0047	phosphoribosylformylglycinamidine synthase activity
S6FBBBH3_RS04925	COG1353	crispr-associated protein
S6FBBBH3_RS04935	COG1337	RAMP superfamily
S6FBBBH3_RS04955	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
S6FBBBH3_RS04960	COG1518	maintenance of DNA repeat elements
S6FBBBH3_RS04995	COG1957	nucleoside hydrolase
S6FBBBH3_RS05000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S6FBBBH3_RS05010	COG1918	ferrous iron import across plasma membrane
S6FBBBH3_RS05015	COG0287	Prephenate dehydrogenase
S6FBBBH3_RS05015	COG1605	Chorismate mutase
S6FBBBH3_RS05020	COG0655	NAD(P)H dehydrogenase (quinone) activity
S6FBBBH3_RS05030	COG1053	succinate dehydrogenase
S6FBBBH3_RS05050	COG1979	alcohol dehydrogenase
S6FBBBH3_RS05055	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
S6FBBBH3_RS05075	COG0842	Transport permease protein
S6FBBBH3_RS05080	COG1053	succinate dehydrogenase
S6FBBBH3_RS05090	COG2195	Cleaves the N-terminal amino acid of tripeptides
S6FBBBH3_RS05095	COG3069	C4-dicarboxylate transmembrane transporter activity
S6FBBBH3_RS05100	COG4191	Histidine kinase
S6FBBBH3_RS05115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS05130	COG3976	FMN-binding domain protein
S6FBBBH3_RS05130	COG0431	NADPH-dependent FMN reductase
S6FBBBH3_RS05130	COG1053	succinate dehydrogenase
S6FBBBH3_RS05135	COG3976	FMN-binding domain protein
S6FBBBH3_RS05135	COG1053	succinate dehydrogenase
S6FBBBH3_RS05135	COG0431	NADPH-dependent FMN reductase
S6FBBBH3_RS05140	COG4566	intracellular signal transduction
S6FBBBH3_RS05150	COG1858	cytochrome C peroxidase
S6FBBBH3_RS05155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
S6FBBBH3_RS05160	COG1918	ferrous iron import across plasma membrane
S6FBBBH3_RS05180	COG0783	Belongs to the Dps family
S6FBBBH3_RS05190	COG0583	DNA-binding transcription factor activity
S6FBBBH3_RS05210	COG1574	metal-dependent hydrolase with the TIM-barrel fold
S6FBBBH3_RS05215	COG0531	amino acid
S6FBBBH3_RS05235	COG0789	Transcriptional regulator
S6FBBBH3_RS05245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S6FBBBH3_RS05265	COG1295	ribonuclease BN
S6FBBBH3_RS05275	COG2205	protein histidine kinase activity
S6FBBBH3_RS05275	COG0784	Response regulator, receiver
S6FBBBH3_RS05280	COG1459	type II secretion system
S6FBBBH3_RS05285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S6FBBBH3_RS05290	COG4796	Type ii and iii secretion system protein
S6FBBBH3_RS05330	COG3706	GGDEF domain
S6FBBBH3_RS05335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S6FBBBH3_RS05335	COG2205	protein histidine kinase activity
S6FBBBH3_RS05380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S6FBBBH3_RS05385	COG2917	probably involved in intracellular septation
S6FBBBH3_RS05390	COG0612	Peptidase, M16
S6FBBBH3_RS05400	COG1053	succinate dehydrogenase
S6FBBBH3_RS05405	COG0758	DNA mediated transformation
S6FBBBH3_RS05405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S6FBBBH3_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
S6FBBBH3_RS05455	COG1053	succinate dehydrogenase
S6FBBBH3_RS05455	COG3976	FMN-binding domain protein
S6FBBBH3_RS05470	COG3069	C4-dicarboxylate transmembrane transporter activity
S6FBBBH3_RS05480	COG2986	histidine ammonia-lyase
S6FBBBH3_RS05485	COG0037	tRNA processing
S6FBBBH3_RS05500	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
S6FBBBH3_RS05515	COG1309	transcriptional regulator
S6FBBBH3_RS05520	COG1053	succinate dehydrogenase
S6FBBBH3_RS05520	COG3976	FMN-binding domain protein
S6FBBBH3_RS05525	COG2986	histidine ammonia-lyase
S6FBBBH3_RS05530	COG2271	Major facilitator Superfamily
S6FBBBH3_RS05555	COG1606	tRNA processing
S6FBBBH3_RS05565	COG1691	(AIR) carboxylase
S6FBBBH3_RS05570	COG3875	lactate racemase activity
S6FBBBH3_RS05590	COG0656	L-ascorbic acid biosynthetic process
S6FBBBH3_RS05595	COG1053	succinate dehydrogenase
S6FBBBH3_RS05605	COG3850	Histidine kinase
S6FBBBH3_RS05605	COG0642	Histidine kinase
S6FBBBH3_RS05610	COG0745	RESPONSE REGULATOR receiver
S6FBBBH3_RS05630	COG3188	usher protein
S6FBBBH3_RS05635	COG3121	Chaperone
S6FBBBH3_RS05660	COG1053	succinate dehydrogenase
S6FBBBH3_RS05665	COG4566	intracellular signal transduction
S6FBBBH3_RS05670	COG1053	succinate dehydrogenase
S6FBBBH3_RS05685	COG0251	oxidation-reduction process
S6FBBBH3_RS05695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S6FBBBH3_RS05720	COG0215	cysteine-tRNA ligase activity
S6FBBBH3_RS05725	COG0825	malonyl-CoA metabolic process
S6FBBBH3_RS05730	COG2239	Acts as a magnesium transporter
S6FBBBH3_RS05745	COG4191	Histidine kinase
S6FBBBH3_RS05745	COG2205	protein histidine kinase activity
S6FBBBH3_RS05745	COG0745	RESPONSE REGULATOR receiver
S6FBBBH3_RS05750	COG4566	intracellular signal transduction
S6FBBBH3_RS05755	COG1053	succinate dehydrogenase
S6FBBBH3_RS05775	COG0494	nUDIX hydrolase
S6FBBBH3_RS05795	COG2205	protein histidine kinase activity
S6FBBBH3_RS05795	COG0784	Response regulator, receiver
S6FBBBH3_RS05810	COG1283	sodium-dependent phosphate transmembrane transporter activity
S6FBBBH3_RS05820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
S6FBBBH3_RS05830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS05845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S6FBBBH3_RS05875	COG0298	carbon dioxide binding
S6FBBBH3_RS05890	COG1773	rubredoxin
S6FBBBH3_RS05895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S6FBBBH3_RS05905	COG0833	amino acid
S6FBBBH3_RS05920	COG0842	Transport permease protein
S6FBBBH3_RS05925	COG0842	Transport permease protein
S6FBBBH3_RS05930	COG1131	(ABC) transporter
S6FBBBH3_RS05935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S6FBBBH3_RS05965	COG3976	FMN-binding domain protein
S6FBBBH3_RS05965	COG0431	NADPH-dependent FMN reductase
S6FBBBH3_RS05965	COG1053	succinate dehydrogenase
S6FBBBH3_RS05980	COG1970	mechanosensitive ion channel activity
S6FBBBH3_RS05985	COG1227	inorganic diphosphatase activity
S6FBBBH3_RS06000	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS06020	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
S6FBBBH3_RS06030	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS06040	COG2067	long-chain fatty acid transport protein
S6FBBBH3_RS06045	COG0500	methyltransferase
S6FBBBH3_RS06060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S6FBBBH3_RS06060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S6FBBBH3_RS06080	COG0302	gtp cyclohydrolase
S6FBBBH3_RS06090	COG0602	queuosine metabolic process
S6FBBBH3_RS06100	COG1979	alcohol dehydrogenase
S6FBBBH3_RS06105	COG0252	asparaginase activity
S6FBBBH3_RS06120	COG1288	antiporter activity
S6FBBBH3_RS06125	COG2272	Belongs to the type-B carboxylesterase lipase family
S6FBBBH3_RS06130	COG2186	Transcriptional regulator
S6FBBBH3_RS06175	COG0667	Aldo Keto reductase
S6FBBBH3_RS06190	COG0583	DNA-binding transcription factor activity
S6FBBBH3_RS06195	COG0251	oxidation-reduction process
S6FBBBH3_RS06225	COG1053	succinate dehydrogenase
S6FBBBH3_RS06240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S6FBBBH3_RS06250	COG1205	dead DEAH box helicase
S6FBBBH3_RS06250	COG1111	helicase
S6FBBBH3_RS06255	COG0210	DNA helicase
S6FBBBH3_RS06270	COG1401	restriction endodeoxyribonuclease activity
S6FBBBH3_RS06275	COG4268	DNA restriction-modification system
S6FBBBH3_RS06285	COG1473	amidohydrolase
S6FBBBH3_RS06295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S6FBBBH3_RS06305	COG0326	Molecular chaperone. Has ATPase activity
S6FBBBH3_RS06310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S6FBBBH3_RS06355	COG4566	intracellular signal transduction
S6FBBBH3_RS06365	COG0431	NADPH-dependent FMN reductase
S6FBBBH3_RS06365	COG1053	succinate dehydrogenase
S6FBBBH3_RS06365	COG3976	FMN-binding domain protein
S6FBBBH3_RS06370	COG0583	DNA-binding transcription factor activity
S6FBBBH3_RS06385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S6FBBBH3_RS06390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S6FBBBH3_RS06390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S6FBBBH3_RS06400	COG0833	amino acid
S6FBBBH3_RS06415	COG0419	ATPase involved in DNA repair
S6FBBBH3_RS06435	COG5002	protein histidine kinase activity
S6FBBBH3_RS06440	COG0745	RESPONSE REGULATOR receiver
S6FBBBH3_RS06465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S6FBBBH3_RS06480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S6FBBBH3_RS06490	COG3976	FMN-binding domain protein
S6FBBBH3_RS06490	COG1053	succinate dehydrogenase
S6FBBBH3_RS06500	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
S6FBBBH3_RS06565	COG1473	amidohydrolase
S6FBBBH3_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
S6FBBBH3_RS06620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S6FBBBH3_RS06650	COG0583	DNA-binding transcription factor activity
S6FBBBH3_RS06660	COG0431	NADPH-dependent FMN reductase
S6FBBBH3_RS06660	COG3976	FMN-binding domain protein
S6FBBBH3_RS06660	COG1053	succinate dehydrogenase
S6FBBBH3_RS06680	COG1053	succinate dehydrogenase
S6FBBBH3_RS06685	COG4566	intracellular signal transduction
S6FBBBH3_RS06690	COG4191	Histidine kinase
S6FBBBH3_RS06705	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS06710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS06720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS06725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS06730	COG1053	succinate dehydrogenase
S6FBBBH3_RS06730	COG3976	FMN-binding domain protein
S6FBBBH3_RS06735	COG1272	protein, Hemolysin III
S6FBBBH3_RS06740	COG4566	intracellular signal transduction
S6FBBBH3_RS06765	COG0071	Belongs to the small heat shock protein (HSP20) family
S6FBBBH3_RS06770	COG2249	NAD(P)H dehydrogenase (quinone) activity
S6FBBBH3_RS06795	COG1309	transcriptional regulator
S6FBBBH3_RS06805	COG0765	amino acid transport
S6FBBBH3_RS06810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S6FBBBH3_RS06815	COG1053	succinate dehydrogenase
S6FBBBH3_RS06820	COG0288	reversible hydration of carbon dioxide
S6FBBBH3_RS06830	COG1473	amidohydrolase
S6FBBBH3_RS06865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
S6FBBBH3_RS06870	COG0531	amino acid
S6FBBBH3_RS06875	COG0589	response to stress
S6FBBBH3_RS06890	COG1794	racemase activity, acting on amino acids and derivatives
S6FBBBH3_RS06910	COG1053	succinate dehydrogenase
S6FBBBH3_RS06920	COG0385	Bile acid
S6FBBBH3_RS06950	COG3681	Belongs to the UPF0597 family
S6FBBBH3_RS06970	COG0531	amino acid
S6FBBBH3_RS06975	COG1982	Orn Lys Arg decarboxylase major
S6FBBBH3_RS07095	COG3451	type IV secretory pathway VirB4
S6FBBBH3_RS07195	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS07205	COG3976	FMN-binding domain protein
S6FBBBH3_RS07205	COG1053	succinate dehydrogenase
S6FBBBH3_RS07210	COG1053	succinate dehydrogenase
S6FBBBH3_RS07220	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS07225	COG0243	molybdopterin cofactor binding
S6FBBBH3_RS07235	COG0243	molybdopterin cofactor binding
S6FBBBH3_RS07240	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS07260	COG3976	FMN-binding domain protein
S6FBBBH3_RS07260	COG1053	succinate dehydrogenase
S6FBBBH3_RS07265	COG1053	succinate dehydrogenase
S6FBBBH3_RS07265	COG3976	FMN-binding domain protein
S6FBBBH3_RS07270	COG1053	succinate dehydrogenase
S6FBBBH3_RS07285	COG1053	succinate dehydrogenase
S6FBBBH3_RS07290	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS07305	COG3976	FMN-binding domain protein
S6FBBBH3_RS07305	COG1053	succinate dehydrogenase
S6FBBBH3_RS07315	COG1053	succinate dehydrogenase
S6FBBBH3_RS07345	COG1053	succinate dehydrogenase
S6FBBBH3_RS07365	COG3550	peptidyl-serine autophosphorylation
S6FBBBH3_RS07405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S6FBBBH3_RS07500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S6FBBBH3_RS07560	COG1368	sulfuric ester hydrolase activity
S6FBBBH3_RS07580	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
S6FBBBH3_RS07585	COG0156	8-amino-7-oxononanoate synthase activity
S6FBBBH3_RS07590	COG3321	synthase
S6FBBBH3_RS07590	COG0604	alcohol dehydrogenase
S6FBBBH3_RS07590	COG1028	Short-chain dehydrogenase reductase Sdr
S6FBBBH3_RS07595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS07625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS07660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S6FBBBH3_RS07665	COG0243	molybdopterin cofactor binding
S6FBBBH3_RS07670	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS07715	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS07720	COG0243	molybdopterin cofactor binding
S6FBBBH3_RS07730	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
S6FBBBH3_RS07750	COG1401	restriction endodeoxyribonuclease activity
S6FBBBH3_RS07760	COG0309	Hydrogenase expression formation protein (HypE)
S6FBBBH3_RS07765	COG0409	Hydrogenase expression formation protein
S6FBBBH3_RS07775	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
S6FBBBH3_RS07780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
S6FBBBH3_RS07785	COG0375	protein maturation
S6FBBBH3_RS07800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S6FBBBH3_RS07810	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
S6FBBBH3_RS07815	COG1053	succinate dehydrogenase
S6FBBBH3_RS07815	COG3976	FMN-binding domain protein
S6FBBBH3_RS07820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS07830	COG1574	metal-dependent hydrolase with the TIM-barrel fold
S6FBBBH3_RS07835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S6FBBBH3_RS07855	COG3188	usher protein
S6FBBBH3_RS07865	COG3121	Chaperone
S6FBBBH3_RS07875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S6FBBBH3_RS07885	COG1966	Carbon starvation protein
S6FBBBH3_RS07895	COG2807	transmembrane transport
S6FBBBH3_RS07915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S6FBBBH3_RS07925	COG4191	Histidine kinase
S6FBBBH3_RS07930	COG4566	intracellular signal transduction
S6FBBBH3_RS07940	COG1053	succinate dehydrogenase
S6FBBBH3_RS07945	COG1982	Orn Lys Arg decarboxylase major
S6FBBBH3_RS07965	COG1136	(ABC) transporter
S6FBBBH3_RS07980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S6FBBBH3_RS07985	COG0484	heat shock protein binding
S6FBBBH3_RS07990	COG4191	Histidine kinase
S6FBBBH3_RS08020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S6FBBBH3_RS08025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S6FBBBH3_RS08055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S6FBBBH3_RS08060	COG0444	Belongs to the ABC transporter superfamily
S6FBBBH3_RS08070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S6FBBBH3_RS08075	COG0601	transmembrane transport
S6FBBBH3_RS08080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S6FBBBH3_RS08085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S6FBBBH3_RS08135	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
S6FBBBH3_RS08155	COG4133	protoheme IX ABC transporter activity
S6FBBBH3_RS08165	COG0322	excinuclease ABC activity
S6FBBBH3_RS08170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S6FBBBH3_RS08180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S6FBBBH3_RS08200	COG1473	amidohydrolase
S6FBBBH3_RS08215	COG0402	S-adenosylhomocysteine deaminase activity
S6FBBBH3_RS08220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S6FBBBH3_RS08225	COG0531	amino acid
S6FBBBH3_RS08230	COG2197	response regulator
S6FBBBH3_RS08235	COG1126	abc transporter atp-binding protein
S6FBBBH3_RS08240	COG0765	amino acid transport
S6FBBBH3_RS08250	COG3069	C4-dicarboxylate transmembrane transporter activity
S6FBBBH3_RS08255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S6FBBBH3_RS08270	COG2198	Histidine kinase
S6FBBBH3_RS08270	COG0784	Response regulator, receiver
S6FBBBH3_RS08270	COG5002	protein histidine kinase activity
S6FBBBH3_RS08275	COG1619	proteins homologs of microcin C7 resistance protein MccF
S6FBBBH3_RS08280	COG0590	tRNA wobble adenosine to inosine editing
S6FBBBH3_RS08295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
S6FBBBH3_RS08300	COG0833	amino acid
S6FBBBH3_RS08310	COG2217	Heavy metal translocating P-type atpase
S6FBBBH3_RS08315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S6FBBBH3_RS08320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S6FBBBH3_RS08330	COG1473	amidohydrolase
S6FBBBH3_RS08335	COG3069	C4-dicarboxylate transmembrane transporter activity
S6FBBBH3_RS08365	COG0745	RESPONSE REGULATOR receiver
S6FBBBH3_RS08370	COG1053	succinate dehydrogenase
S6FBBBH3_RS08380	COG0833	amino acid
S6FBBBH3_RS08395	COG1518	maintenance of DNA repeat elements
S6FBBBH3_RS08435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S6FBBBH3_RS08450	COG0583	DNA-binding transcription factor activity
S6FBBBH3_RS08470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
S6FBBBH3_RS08475	COG0583	DNA-binding transcription factor activity
S6FBBBH3_RS08480	COG0039	L-malate dehydrogenase activity
S6FBBBH3_RS08510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S6FBBBH3_RS08515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S6FBBBH3_RS08525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S6FBBBH3_RS08560	COG0656	L-ascorbic acid biosynthetic process
S6FBBBH3_RS08565	COG1464	Belongs to the NlpA lipoprotein family
S6FBBBH3_RS08575	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S6FBBBH3_RS08585	COG4566	intracellular signal transduction
S6FBBBH3_RS08595	COG3585	molybdate ion transport
S6FBBBH3_RS08605	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
S6FBBBH3_RS08615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S6FBBBH3_RS08615	COG1017	nitric oxide dioxygenase activity
S6FBBBH3_RS08620	COG1959	2 iron, 2 sulfur cluster binding
S6FBBBH3_RS08625	COG4566	intracellular signal transduction
S6FBBBH3_RS08640	COG0583	DNA-binding transcription factor activity
S6FBBBH3_RS08645	COG1053	succinate dehydrogenase
S6FBBBH3_RS08665	COG0243	molybdopterin cofactor binding
S6FBBBH3_RS08670	COG0437	4 iron, 4 sulfur cluster binding
S6FBBBH3_RS08675	COG2954	triphosphatase activity
S6FBBBH3_RS08685	COG1053	succinate dehydrogenase
S6FBBBH3_RS08760	COG0084	hydrolase, TatD family'
S6FBBBH3_RS08770	COG0826	peptidase U32
S6FBBBH3_RS08785	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
S6FBBBH3_RS08790	COG1115	amino acid carrier protein
S6FBBBH3_RS08800	COG2914	Belongs to the UPF0125 (RnfH) family
S6FBBBH3_RS08805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S6FBBBH3_RS08810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S6FBBBH3_RS08815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S6FBBBH3_RS08820	COG1120	ATPase activity
S6FBBBH3_RS08830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S6FBBBH3_RS08835	COG0473	3-isopropylmalate dehydrogenase activity
S6FBBBH3_RS08850	COG0431	NADPH-dependent FMN reductase
S6FBBBH3_RS08850	COG1053	succinate dehydrogenase
S6FBBBH3_RS08850	COG3976	FMN-binding domain protein
S6FBBBH3_RS08890	COG0583	DNA-binding transcription factor activity
S6FBBBH3_RS08915	COG4977	sequence-specific DNA binding
S6FBBBH3_RS08915	COG1917	Cupin 2, conserved barrel domain protein
S6FBBBH3_RS08925	COG0540	Belongs to the ATCase OTCase family
S6FBBBH3_RS08930	COG3257	ureidoglycine aminohydrolase activity
S6FBBBH3_RS08965	COG1022	Amp-dependent synthetase and ligase
S6FBBBH3_RS08970	COG1022	Amp-dependent synthetase and ligase
S6FBBBH3_RS08975	COG0517	IMP dehydrogenase activity
S6FBBBH3_RS08975	COG0516	GMP reductase activity
S6FBBBH3_RS08980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S6FBBBH3_RS08980	COG0519	Catalyzes the synthesis of GMP from XMP
S6FBBBH3_RS09015	COG3850	Histidine kinase
S6FBBBH3_RS09030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S6FBBBH3_RS09060	COG0745	RESPONSE REGULATOR receiver
S6FBBBH3_RS09065	COG2205	protein histidine kinase activity
S6FBBBH3_RS09070	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
S6FBBBH3_RS09075	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
S6FBBBH3_RS09080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
S6FBBBH3_RS09090	COG1174	glycine betaine transport
S6FBBBH3_RS09095	COG1125	glycine betaine transport
S6FBBBH3_RS09095	COG0517	IMP dehydrogenase activity
S6FBBBH3_RS09100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S6FBBBH3_RS09125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S6FBBBH3_RS09140	COG0544	peptidyl-prolyl cis-trans isomerase activity
S6FBBBH3_RS09165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S6FBBBH3_RS09180	COG0285	dihydrofolate synthase activity
S6FBBBH3_RS09190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S6FBBBH3_RS09195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S6FBBBH3_RS09200	COG0101	tRNA pseudouridine synthase activity
S6FBBBH3_RS09210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
S6FBBBH3_RS09215	COG2116	formate transmembrane transporter activity
S6FBBBH3_RS09230	COG0564	pseudouridine synthase activity
S6FBBBH3_RS09245	COG0123	including yeast histone deacetylase and acetoin utilization protein
S6FBBBH3_RS09250	COG2951	lytic endotransglycosylase activity
S6FBBBH3_RS09255	COG0697	spore germination
S6FBBBH3_RS09260	COG0179	Fumarylacetoacetate (FAA) hydrolase
S6FBBBH3_RS09265	COG1183	phosphatidylcholine synthase activity
S6FBBBH3_RS09290	COG0733	neurotransmitter:sodium symporter activity
S6FBBBH3_RS09295	COG0733	neurotransmitter:sodium symporter activity
S6FBBBH3_RS09300	COG0733	neurotransmitter:sodium symporter activity
S6FBBBH3_RS09305	COG0733	neurotransmitter:sodium symporter activity
S6FBBBH3_RS09310	COG1280	lysine exporter protein (LysE YggA)
S6FBBBH3_RS09325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S6FBBBH3_RS09330	COG1199	ATP-dependent helicase activity
S6FBBBH3_RS09345	COG3069	C4-dicarboxylate transmembrane transporter activity
S6FBBBH3_RS09375	COG3842	ATPase activity
S6FBBBH3_RS09405	COG3976	FMN-binding domain protein
S6FBBBH3_RS09405	COG0431	NADPH-dependent FMN reductase
S6FBBBH3_RS09405	COG1053	succinate dehydrogenase
S6FBBBH3_RS09420	COG0039	L-malate dehydrogenase activity
S6FBBBH3_RS09425	COG1253	flavin adenine dinucleotide binding
S6FBBBH3_RS09435	COG0737	Belongs to the 5'-nucleotidase family
S6FBBBH3_RS09440	COG1115	amino acid carrier protein
S6FBBBH3_RS09455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S6FBBBH3_RS09455	COG4651	solute:proton antiporter activity
S6FBBBH3_RS09465	COG1079	Belongs to the binding-protein-dependent transport system permease family
S6FBBBH3_RS09470	COG4603	Belongs to the binding-protein-dependent transport system permease family
S6FBBBH3_RS09475	COG3845	ABC transporter
S6FBBBH3_RS09490	COG0494	nUDIX hydrolase
S6FBBBH3_RS09495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
S6FBBBH3_RS09495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S6FBBBH3_RS09510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S6FBBBH3_RS09515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S6FBBBH3_RS09520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S6FBBBH3_RS09550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
S6FBBBH3_RS09555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S6FBBBH3_RS09560	COG3842	ATPase activity
S6FBBBH3_RS09565	COG1176	ABC-type spermidine putrescine transport system, permease component I
S6FBBBH3_RS09575	COG1840	ABC-type Fe3 transport system, periplasmic component
S6FBBBH3_RS09585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S6FBBBH3_RS09590	COG1966	Carbon starvation protein
S6FBBBH3_RS09615	COG1846	Transcriptional regulator
S6FBBBH3_RS09620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S6FBBBH3_RS09625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S6FBBBH3_RS09630	COG0765	amino acid transport
S6FBBBH3_RS09635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S6FBBBH3_RS09640	COG1185	polyribonucleotide nucleotidyltransferase activity
S6FBBBH3_RS09645	COG0149	triose-phosphate isomerase activity
S6FBBBH3_RS09705	COG1472	Belongs to the glycosyl hydrolase 3 family
S6FBBBH3_RS09710	COG1381	Involved in DNA repair and RecF pathway recombination
S6FBBBH3_RS09715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S6FBBBH3_RS09720	COG0571	ribonuclease III activity
S6FBBBH3_RS09730	COG0481	GTPase activity
S6FBBBH3_RS09740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S6FBBBH3_RS09745	COG1028	Short-chain dehydrogenase reductase Sdr
S6FBBBH3_RS09750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S6FBBBH3_RS09755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S6FBBBH3_RS09760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S6FBBBH3_RS09795	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
S6FBBBH3_RS09800	COG1027	Aspartate ammonia-lyase
S6FBBBH3_RS09805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S6FBBBH3_RS09810	COG1053	succinate dehydrogenase
S6FBBBH3_RS09825	COG0628	permease
S6FBBBH3_RS09835	COG3069	C4-dicarboxylate transmembrane transporter activity
S6FBBBH3_RS09840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
S6FBBBH3_RS09850	COG1162	GTPase activity
S6FBBBH3_RS09855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S6FBBBH3_RS09860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S6FBBBH3_RS09875	COG0542	response to heat
S6FBBBH3_RS09880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S6FBBBH3_RS09885	COG0314	molybdopterin synthase activity
S6FBBBH3_RS09890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S6FBBBH3_RS09895	COG0303	'Molybdopterin
S6FBBBH3_RS09900	COG1763	Mo-molybdopterin cofactor biosynthetic process
S6FBBBH3_RS09915	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S6FBBBH3_RS09925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S6FBBBH3_RS09930	COG1074	ATP-dependent DNA helicase activity
S6FBBBH3_RS09935	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
S6FBBBH3_RS09950	COG0305	Participates in initiation and elongation during chromosome replication
S6FBBBH3_RS09955	COG0359	binds to the 23S rRNA
S6FBBBH3_RS09960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S6FBBBH3_RS09970	COG0360	Binds together with S18 to 16S ribosomal RNA
S6FBBBH3_RS09975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S6FBBBH3_RS09980	COG0557	exoribonuclease II activity
S6FBBBH3_RS09995	COG0583	DNA-binding transcription factor activity
S6FBBBH3_RS10005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S6FBBBH3_RS10010	COG1397	ADP-ribosylglycohydrolase
S6FBBBH3_RS10020	COG3264	Mechanosensitive ion channel
S6FBBBH3_RS10020	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
S6FBBBH3_RS10025	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
S6FBBBH3_RS10030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S6FBBBH3_RS10040	COG0330	HflC and HflK could
S6FBBBH3_RS10045	COG0330	HflC and HflK could
S6FBBBH3_RS10050	COG3366	ferrous iron transmembrane transporter activity
S6FBBBH3_RS10055	COG0700	Nucleoside recognition
S6FBBBH3_RS10065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S6FBBBH3_RS10070	COG2223	nitrite transmembrane transporter activity
S6FBBBH3_RS10075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S6FBBBH3_RS10080	COG1923	regulation of RNA biosynthetic process
S6FBBBH3_RS10085	COG1160	GTP binding
S6FBBBH3_RS10090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S6FBBBH3_RS10095	COG2976	Protein conserved in bacteria
S6FBBBH3_RS10105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S6FBBBH3_RS10110	COG1426	Protein conserved in bacteria
S6FBBBH3_RS10115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S6FBBBH3_RS10120	COG0105	UTP biosynthetic process
S6FBBBH3_RS10130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S6FBBBH3_RS10140	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
S6FBBBH3_RS10145	COG1473	amidohydrolase
S6FBBBH3_RS10155	COG5002	protein histidine kinase activity
S6FBBBH3_RS10170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S6FBBBH3_RS10175	COG0581	inorganic phosphate transmembrane transporter activity
S6FBBBH3_RS10180	COG0573	inorganic phosphate transmembrane transporter activity
S6FBBBH3_RS10195	COG0776	regulation of translation
S6FBBBH3_RS10200	COG0072	phenylalanine-tRNA ligase activity
S6FBBBH3_RS10200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S6FBBBH3_RS10205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S6FBBBH3_RS10210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S6FBBBH3_RS10215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S6FBBBH3_RS10220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S6FBBBH3_RS10225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S6FBBBH3_RS10240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S6FBBBH3_RS10270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S6FBBBH3_RS10280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S6FBBBH3_RS10290	COG2975	iron-sulfur cluster assembly
S6FBBBH3_RS10295	COG0633	Ferredoxin
S6FBBBH3_RS10305	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
S6FBBBH3_RS10310	COG0316	Belongs to the HesB IscA family
S6FBBBH3_RS10315	COG0822	iron-sulfur transferase activity
S6FBBBH3_RS10320	COG1104	cysteine desulfurase activity
S6FBBBH3_RS10325	COG1959	2 iron, 2 sulfur cluster binding
S6FBBBH3_RS10330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S6FBBBH3_RS10335	COG0556	nucleotide-excision repair
S6FBBBH3_RS10350	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S6FBBBH3_RS10375	COG0746	molybdenum cofactor guanylyltransferase activity
S6FBBBH3_RS10380	COG0303	'Molybdopterin
S6FBBBH3_RS10385	COG2129	metallophosphoesterase
S6FBBBH3_RS10395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S6FBBBH3_RS10405	COG1674	ftsk spoiiie
S6FBBBH3_RS10410	COG0492	ferredoxin-NADP+ reductase activity
S6FBBBH3_RS10420	COG0347	Belongs to the P(II) protein family
S6FBBBH3_RS10430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S6FBBBH3_RS10435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S6FBBBH3_RS10440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S6FBBBH3_RS10445	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
S6FBBBH3_RS10450	COG1534	Rna-binding protein
S6FBBBH3_RS10455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S6FBBBH3_RS10460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
S6FBBBH3_RS10465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S6FBBBH3_RS10475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S6FBBBH3_RS10485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S6FBBBH3_RS10505	COG3118	belongs to the thioredoxin family
S6FBBBH3_RS10510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S6FBBBH3_RS10525	COG0181	hydroxymethylbilane synthase activity
S6FBBBH3_RS10530	COG0254	rRNA binding
S6FBBBH3_RS10540	COG0534	Mate efflux family protein
S6FBBBH3_RS10545	COG0501	Belongs to the peptidase M48B family
S6FBBBH3_RS10555	COG0776	regulation of translation
S6FBBBH3_RS10565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S6FBBBH3_RS10570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S6FBBBH3_RS10580	COG0402	S-adenosylhomocysteine deaminase activity
S6FBBBH3_RS10595	COG0826	peptidase U32
S6FBBBH3_RS10615	COG0802	atpase or kinase
S6FBBBH3_RS10620	COG0860	N-Acetylmuramoyl-L-alanine amidase
S6FBBBH3_RS10635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S6FBBBH3_RS10640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S6FBBBH3_RS10645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S6FBBBH3_RS10650	COG0009	L-threonylcarbamoyladenylate synthase
S6FBBBH3_RS10660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S6FBBBH3_RS10725	COG0308	aminopeptidase N
S6FBBBH3_RS10730	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
S6FBBBH3_RS10770	COG0424	maF-like protein
S6FBBBH3_RS10775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S6FBBBH3_RS10780	COG0799	negative regulation of ribosome biogenesis
S6FBBBH3_RS10785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S6FBBBH3_RS10795	COG0151	Belongs to the GarS family
S6FBBBH3_RS10805	COG1473	amidohydrolase
S6FBBBH3_RS10815	COG2197	response regulator
S6FBBBH3_RS10820	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
S6FBBBH3_RS10825	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
S6FBBBH3_RS10825	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
S6FBBBH3_RS10840	COG0484	heat shock protein binding
S6FBBBH3_RS10855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S6FBBBH3_RS10860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S6FBBBH3_RS10865	COG0429	hydrolase of the alpha beta-hydrolase fold
S6FBBBH3_RS10870	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
S6FBBBH3_RS10885	COG0312	modulator of DNA gyrase
S6FBBBH3_RS10900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S6FBBBH3_RS10910	COG0318	PFAM AMP-dependent synthetase and ligase
S6FBBBH3_RS10930	COG1380	Effector of murein hydrolase LrgA
S6FBBBH3_RS10935	COG1346	cytolysis
S6FBBBH3_RS10940	COG0471	metal ion transport
S6FBBBH3_RS10945	COG2070	2-Nitropropane dioxygenase
S6FBBBH3_RS10950	COG0482	sulfurtransferase activity
S6FBBBH3_RS10955	COG0861	Integral membrane protein TerC family