locus-tag	class	description
I6J16_RS00005	COG0746	molybdenum cofactor guanylyltransferase activity
I6J16_RS00030	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J16_RS00045	COG0556	nucleotide-excision repair
I6J16_RS00050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J16_RS00055	COG1959	2 iron, 2 sulfur cluster binding
I6J16_RS00060	COG1104	cysteine desulfurase activity
I6J16_RS00065	COG0822	iron-sulfur transferase activity
I6J16_RS00070	COG0316	Belongs to the HesB IscA family
I6J16_RS00075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6J16_RS00080	COG0443	Heat shock 70 kDa protein
I6J16_RS00085	COG0633	Ferredoxin
I6J16_RS00090	COG2975	iron-sulfur cluster assembly
I6J16_RS00105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J16_RS00115	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J16_RS00130	COG1136	(ABC) transporter
I6J16_RS00135	COG0084	hydrolase, TatD family'
I6J16_RS00145	COG2848	UPF0210 protein
I6J16_RS00160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J16_RS00175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J16_RS00180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J16_RS00185	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J16_RS00190	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J16_RS00195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J16_RS00200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J16_RS00200	COG0072	phenylalanine-tRNA ligase activity
I6J16_RS00205	COG0776	regulation of translation
I6J16_RS00245	COG5377	YqaJ viral recombinase family
I6J16_RS00265	COG3617	BRO family, N-terminal domain
I6J16_RS00270	COG3692	DNA binding
I6J16_RS00340	COG4626	Terminase
I6J16_RS00340	COG1802	Transcriptional regulator
I6J16_RS00345	COG4695	Portal protein
I6J16_RS00380	COG4386	tail sheath protein
I6J16_RS00430	COG3299	homolog of phage Mu protein gp47
I6J16_RS00450	COG0582	viral genome integration into host DNA
I6J16_RS00520	COG0573	inorganic phosphate transmembrane transporter activity
I6J16_RS00525	COG0581	inorganic phosphate transmembrane transporter activity
I6J16_RS00535	COG0704	Plays a role in the regulation of phosphate uptake
I6J16_RS00550	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6J16_RS00560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J16_RS00570	COG0287	Prephenate dehydrogenase
I6J16_RS00570	COG1605	Chorismate mutase
I6J16_RS00575	COG0105	UTP biosynthetic process
I6J16_RS00580	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J16_RS00595	COG0124	histidyl-tRNA synthetase
I6J16_RS00600	COG2976	Protein conserved in bacteria
I6J16_RS00605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J16_RS00610	COG1160	GTP binding
I6J16_RS00620	COG1923	regulation of RNA biosynthetic process
I6J16_RS00625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J16_RS00635	COG0700	Nucleoside recognition
I6J16_RS00640	COG0330	HflC and HflK could
I6J16_RS00645	COG0330	HflC and HflK could
I6J16_RS00655	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J16_RS00675	COG1397	ADP-ribosylglycohydrolase
I6J16_RS00680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J16_RS00695	COG0557	exoribonuclease II activity
I6J16_RS00700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J16_RS00705	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J16_RS00710	COG2965	DNA replication, synthesis of RNA primer
I6J16_RS00715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J16_RS00720	COG0359	binds to the 23S rRNA
I6J16_RS00725	COG0305	Participates in initiation and elongation during chromosome replication
I6J16_RS00740	COG1074	ATP-dependent DNA helicase activity
I6J16_RS00745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J16_RS00750	COG0583	DNA-binding transcription factor activity
I6J16_RS00755	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS00760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J16_RS00770	COG0165	Argininosuccinate lyase
I6J16_RS00780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J16_RS00785	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J16_RS00795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J16_RS00800	COG0303	'Molybdopterin
I6J16_RS00805	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6J16_RS00810	COG0314	molybdopterin synthase activity
I6J16_RS00815	COG0542	response to heat
I6J16_RS00825	COG2272	Belongs to the type-B carboxylesterase lipase family
I6J16_RS00835	COG4566	intracellular signal transduction
I6J16_RS00840	COG1053	succinate dehydrogenase
I6J16_RS00840	COG3976	FMN-binding domain protein
I6J16_RS00850	COG0747	negative chemotaxis
I6J16_RS00855	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J16_RS00860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J16_RS00865	COG1162	GTPase activity
I6J16_RS00875	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6J16_RS00880	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS00885	COG1760	l-serine dehydratase
I6J16_RS00890	COG0628	permease
I6J16_RS00900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J16_RS00910	COG1053	succinate dehydrogenase
I6J16_RS00915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J16_RS00920	COG1027	Aspartate ammonia-lyase
I6J16_RS00925	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J16_RS00950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J16_RS00970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J16_RS00975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J16_RS00980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J16_RS00985	COG1028	Short-chain dehydrogenase reductase Sdr
I6J16_RS00990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J16_RS00995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J16_RS01010	COG0571	ribonuclease III activity
I6J16_RS01015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J16_RS01020	COG1381	Involved in DNA repair and RecF pathway recombination
I6J16_RS01025	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J16_RS01030	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J16_RS01040	COG2860	membrane
I6J16_RS01045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J16_RS01055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J16_RS01095	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J16_RS01100	COG0149	triose-phosphate isomerase activity
I6J16_RS01105	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J16_RS01110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J16_RS01115	COG0765	amino acid transport
I6J16_RS01120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J16_RS01125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J16_RS01155	COG3976	FMN-binding domain protein
I6J16_RS01155	COG0431	NADPH-dependent FMN reductase
I6J16_RS01155	COG1053	succinate dehydrogenase
I6J16_RS01160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J16_RS01180	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6J16_RS01185	COG1399	metal-binding, possibly nucleic acid-binding protein
I6J16_RS01190	COG0424	maF-like protein
I6J16_RS01225	COG1337	RAMP superfamily
I6J16_RS01275	COG1518	maintenance of DNA repeat elements
I6J16_RS01295	COG4953	penicillin-binding protein 1C
I6J16_RS01305	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6J16_RS01310	COG1286	toxin biosynthetic process
I6J16_RS01325	COG0285	dihydrofolate synthase activity
I6J16_RS01330	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J16_RS01335	COG0101	tRNA pseudouridine synthase activity
I6J16_RS01345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J16_RS01355	COG0564	pseudouridine synthase activity
I6J16_RS01375	COG2951	lytic endotransglycosylase activity
I6J16_RS01380	COG1473	amidohydrolase
I6J16_RS01395	COG1183	phosphatidylcholine synthase activity
I6J16_RS01420	COG0733	neurotransmitter:sodium symporter activity
I6J16_RS01425	COG0733	neurotransmitter:sodium symporter activity
I6J16_RS01430	COG0733	neurotransmitter:sodium symporter activity
I6J16_RS01435	COG0733	neurotransmitter:sodium symporter activity
I6J16_RS01445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J16_RS01450	COG1199	ATP-dependent helicase activity
I6J16_RS01465	COG0778	Nitroreductase
I6J16_RS01470	COG0039	L-malate dehydrogenase activity
I6J16_RS01480	COG1115	amino acid carrier protein
I6J16_RS01505	COG3976	FMN-binding domain protein
I6J16_RS01505	COG1053	succinate dehydrogenase
I6J16_RS01505	COG0431	NADPH-dependent FMN reductase
I6J16_RS01510	COG0613	PHP domain protein
I6J16_RS01515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J16_RS01520	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6J16_RS01530	COG0148	phosphopyruvate hydratase activity
I6J16_RS01535	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6J16_RS01540	COG0504	CTP synthase activity
I6J16_RS01545	COG1230	cation diffusion facilitator family transporter
I6J16_RS01550	COG0137	argininosuccinate synthase activity
I6J16_RS01560	COG0252	asparaginase activity
I6J16_RS01565	COG0351	phosphomethylpyrimidine kinase
I6J16_RS01585	COG0531	amino acid
I6J16_RS01605	COG2814	Major facilitator Superfamily
I6J16_RS01620	COG0531	amino acid
I6J16_RS01625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J16_RS01630	COG1982	Orn Lys Arg decarboxylase major
I6J16_RS01635	COG0531	amino acid
I6J16_RS01640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J16_RS01645	COG1757	Na H antiporter
I6J16_RS01650	COG1982	Orn Lys Arg decarboxylase major
I6J16_RS01655	COG0531	amino acid
I6J16_RS01660	COG0531	amino acid
I6J16_RS01665	COG3710	Transcriptional regulator
I6J16_RS01670	COG4191	Histidine kinase
I6J16_RS01675	COG4566	intracellular signal transduction
I6J16_RS01680	COG1053	succinate dehydrogenase
I6J16_RS01685	COG1053	succinate dehydrogenase
I6J16_RS01690	COG1473	amidohydrolase
I6J16_RS01695	COG4172	Belongs to the ABC transporter superfamily
I6J16_RS01705	COG0601	transmembrane transport
I6J16_RS01710	COG0747	negative chemotaxis
I6J16_RS01720	COG0647	UMP catabolic process
I6J16_RS01735	COG0395	ABC-type sugar transport system, permease component
I6J16_RS01740	COG1175	transmembrane transport
I6J16_RS01750	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6J16_RS01760	COG1053	succinate dehydrogenase
I6J16_RS01760	COG3976	FMN-binding domain protein
I6J16_RS01780	COG1120	ATPase activity
I6J16_RS01785	COG4774	siderophore transport
I6J16_RS01805	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6J16_RS01815	COG1994	Peptidase M50
I6J16_RS01825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J16_RS01825	COG4651	solute:proton antiporter activity
I6J16_RS01840	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J16_RS01845	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6J16_RS01850	COG3845	ABC transporter
I6J16_RS01870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J16_RS01875	COG3842	ATPase activity
I6J16_RS01880	COG1840	ABC-type Fe3 transport system, periplasmic component
I6J16_RS01890	COG0494	nUDIX hydrolase
I6J16_RS01895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J16_RS01895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J16_RS01900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J16_RS01905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6J16_RS01910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J16_RS01915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J16_RS01920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J16_RS01955	COG1966	Carbon starvation protein
I6J16_RS01980	COG0582	viral genome integration into host DNA
I6J16_RS02040	COG0842	Transport permease protein
I6J16_RS02045	COG0842	Transport permease protein
I6J16_RS02050	COG1131	(ABC) transporter
I6J16_RS02055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J16_RS02065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J16_RS02070	COG1114	Component of the transport system for branched-chain amino acids
I6J16_RS02075	COG2207	Transcriptional regulator
I6J16_RS02085	COG1053	succinate dehydrogenase
I6J16_RS02085	COG3976	FMN-binding domain protein
I6J16_RS02090	COG1012	belongs to the aldehyde dehydrogenase family
I6J16_RS02100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J16_RS02100	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6J16_RS02110	COG1045	serine acetyltransferase
I6J16_RS02125	COG4771	TonB-dependent receptor
I6J16_RS02140	COG1129	ABC transporter
I6J16_RS02155	COG1131	(ABC) transporter
I6J16_RS02160	COG0842	Transport permease protein
I6J16_RS02170	COG3976	FMN-binding domain protein
I6J16_RS02170	COG1053	succinate dehydrogenase
I6J16_RS02190	COG1053	succinate dehydrogenase
I6J16_RS02200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J16_RS02205	COG1126	abc transporter atp-binding protein
I6J16_RS02210	COG0765	amino acid transport
I6J16_RS02225	COG0675	Transposase, IS605 OrfB family
I6J16_RS02245	COG2079	MmgE PrpD family protein
I6J16_RS02250	COG0165	Argininosuccinate lyase
I6J16_RS02255	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J16_RS02260	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J16_RS02265	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J16_RS02270	COG0024	Methionine aminopeptidase
I6J16_RS02280	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J16_RS02285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J16_RS02290	COG0528	UMP kinase activity
I6J16_RS02295	COG0233	cytoplasmic translational termination
I6J16_RS02315	COG0575	Belongs to the CDS family
I6J16_RS02320	COG1739	Uncharacterized protein family UPF0029
I6J16_RS02325	COG1408	metallophosphoesterase
I6J16_RS02330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J16_RS02335	COG0750	zinc metalloprotease
I6J16_RS02345	COG1115	amino acid carrier protein
I6J16_RS02350	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6J16_RS02370	COG0826	peptidase U32
I6J16_RS02380	COG0583	DNA-binding transcription factor activity
I6J16_RS02385	COG0084	hydrolase, TatD family'
I6J16_RS02410	COG0281	malic enzyme
I6J16_RS02435	COG1205	dead DEAH box helicase
I6J16_RS02435	COG1111	helicase
I6J16_RS02460	COG2197	response regulator
I6J16_RS02470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J16_RS02475	COG0402	S-adenosylhomocysteine deaminase activity
I6J16_RS02490	COG1473	amidohydrolase
I6J16_RS02495	COG1979	alcohol dehydrogenase
I6J16_RS02525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J16_RS02555	COG0322	excinuclease ABC activity
I6J16_RS02565	COG4133	protoheme IX ABC transporter activity
I6J16_RS02570	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J16_RS02585	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6J16_RS02610	COG3842	ATPase activity
I6J16_RS02630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J16_RS02630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J16_RS02635	COG0667	Aldo Keto reductase
I6J16_RS02645	COG1757	Na H antiporter
I6J16_RS02680	COG1397	ADP-ribosylglycohydrolase
I6J16_RS02685	COG0352	thiamine-phosphate diphosphorylase activity
I6J16_RS02685	COG0351	phosphomethylpyrimidine kinase
I6J16_RS02685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J16_RS02710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J16_RS02715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J16_RS02725	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J16_RS02730	COG4191	Histidine kinase
I6J16_RS02735	COG0484	heat shock protein binding
I6J16_RS02740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J16_RS02765	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I6J16_RS02770	COG1691	(AIR) carboxylase
I6J16_RS02775	COG2207	Transcriptional regulator
I6J16_RS02795	COG0385	Bile acid
I6J16_RS02805	COG0385	Bile acid
I6J16_RS02820	COG1957	nucleoside hydrolase
I6J16_RS02830	COG0385	Bile acid
I6J16_RS02850	COG0778	Nitroreductase
I6J16_RS02850	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J16_RS02860	COG0601	transmembrane transport
I6J16_RS02865	COG0747	negative chemotaxis
I6J16_RS02870	COG4172	Belongs to the ABC transporter superfamily
I6J16_RS02875	COG1473	amidohydrolase
I6J16_RS02890	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J16_RS02895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J16_RS02900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J16_RS02910	COG0215	cysteine-tRNA ligase activity
I6J16_RS02915	COG0825	malonyl-CoA metabolic process
I6J16_RS02935	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6J16_RS02945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J16_RS02960	COG2184	nucleotidyltransferase activity
I6J16_RS03020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J16_RS03020	COG4651	solute:proton antiporter activity
I6J16_RS03025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J16_RS03030	COG0069	glutamate synthase activity
I6J16_RS03030	COG0067	glutamate synthase
I6J16_RS03030	COG0070	glutamate synthase
I6J16_RS03045	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J16_RS03050	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J16_RS03050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J16_RS03055	COG1982	Orn Lys Arg decarboxylase major
I6J16_RS03090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J16_RS03095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J16_RS03105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J16_RS03115	COG1053	succinate dehydrogenase
I6J16_RS03120	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS03125	COG0165	Argininosuccinate lyase
I6J16_RS03135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J16_RS03135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J16_RS03145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6J16_RS03170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J16_RS03170	COG1333	cytochrome c biogenesis protein
I6J16_RS03180	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6J16_RS03190	COG1960	acyl-CoA dehydrogenase activity
I6J16_RS03195	COG4670	ketone body catabolic process
I6J16_RS03210	COG2271	Major facilitator Superfamily
I6J16_RS03215	COG2086	electron transfer activity
I6J16_RS03220	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J16_RS03225	COG0644	oxidoreductase
I6J16_RS03230	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J16_RS03235	COG0318	PFAM AMP-dependent synthetase and ligase
I6J16_RS03240	COG1053	succinate dehydrogenase
I6J16_RS03245	COG4566	intracellular signal transduction
I6J16_RS03255	COG1053	succinate dehydrogenase
I6J16_RS03260	COG1917	Cupin 2, conserved barrel domain protein
I6J16_RS03260	COG2207	Transcriptional regulator
I6J16_RS03265	COG0738	Major facilitator superfamily
I6J16_RS03300	COG4964	Belongs to the GSP D family
I6J16_RS03395	COG4149	molybdate abc transporter
I6J16_RS03420	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6J16_RS03430	COG0375	protein maturation
I6J16_RS03470	COG1253	flavin adenine dinucleotide binding
I6J16_RS03490	COG2226	methyltransferase
I6J16_RS03495	COG1120	ATPase activity
I6J16_RS03500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J16_RS03505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J16_RS03535	COG1487	ribonuclease activity
I6J16_RS03550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J16_RS03555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J16_RS03560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J16_RS03570	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6J16_RS03575	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6J16_RS03580	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS03590	COG3976	FMN-binding domain protein
I6J16_RS03590	COG1053	succinate dehydrogenase
I6J16_RS03595	COG1053	succinate dehydrogenase
I6J16_RS03625	COG3383	formate dehydrogenase (NAD+) activity
I6J16_RS03635	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J16_RS03645	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J16_RS03650	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J16_RS03665	COG0310	cobalt ion transport
I6J16_RS03685	COG4771	TonB-dependent receptor
I6J16_RS03690	COG0811	peptide transport
I6J16_RS03715	COG4178	(ABC) transporter
I6J16_RS03720	COG4771	TonB-dependent receptor
I6J16_RS03725	COG4566	intracellular signal transduction
I6J16_RS03735	COG3976	FMN-binding domain protein
I6J16_RS03735	COG1053	succinate dehydrogenase
I6J16_RS03740	COG0083	homoserine kinase activity
I6J16_RS03750	COG0460	homoserine dehydrogenase
I6J16_RS03755	COG0527	aspartate kinase activity
I6J16_RS03760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J16_RS03780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J16_RS03785	COG0747	negative chemotaxis
I6J16_RS03795	COG2186	Transcriptional regulator
I6J16_RS03800	COG1280	lysine exporter protein (LysE YggA)
I6J16_RS03805	COG0747	negative chemotaxis
I6J16_RS03825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J16_RS03830	COG1053	succinate dehydrogenase
I6J16_RS03865	COG3264	Mechanosensitive ion channel
I6J16_RS03865	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6J16_RS03875	COG0471	metal ion transport
I6J16_RS03885	COG2171	N-acyltransferase activity
I6J16_RS03895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J16_RS03915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J16_RS03915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J16_RS03925	COG3976	FMN-binding domain protein
I6J16_RS03925	COG1053	succinate dehydrogenase
I6J16_RS03930	COG1053	succinate dehydrogenase
I6J16_RS03940	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6J16_RS03940	COG3264	Mechanosensitive ion channel
I6J16_RS03965	COG0583	DNA-binding transcription factor activity
I6J16_RS03985	COG0657	acetylesterase activity
I6J16_RS03990	COG1464	Belongs to the NlpA lipoprotein family
I6J16_RS04020	COG5002	protein histidine kinase activity
I6J16_RS04025	COG0745	RESPONSE REGULATOR receiver
I6J16_RS04055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J16_RS04060	COG4191	Histidine kinase
I6J16_RS04065	COG4566	intracellular signal transduction
I6J16_RS04085	COG1473	amidohydrolase
I6J16_RS04100	COG3976	FMN-binding domain protein
I6J16_RS04100	COG1053	succinate dehydrogenase
I6J16_RS04105	COG1473	amidohydrolase
I6J16_RS04110	COG0477	Major facilitator Superfamily
I6J16_RS04115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J16_RS04130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J16_RS04150	COG3493	citrate carrier protein
I6J16_RS04155	COG4565	transcriptional regulatory protein
I6J16_RS04160	COG3290	protein histidine kinase activity
I6J16_RS04175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J16_RS04190	COG2204	response regulator
I6J16_RS04215	COG3301	Polysulphide reductase, NrfD
I6J16_RS04220	COG0437	4 iron, 4 sulfur cluster binding
I6J16_RS04235	COG2414	aldehyde ferredoxin oxidoreductase
I6J16_RS04240	COG0437	4 iron, 4 sulfur cluster binding
I6J16_RS04260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J16_RS04265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6J16_RS04270	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J16_RS04295	COG0583	DNA-binding transcription factor activity
I6J16_RS04315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J16_RS04325	COG1053	succinate dehydrogenase
I6J16_RS04325	COG3976	FMN-binding domain protein
I6J16_RS04330	COG1053	succinate dehydrogenase
I6J16_RS04335	COG0745	RESPONSE REGULATOR receiver
I6J16_RS04345	COG3976	FMN-binding domain protein
I6J16_RS04345	COG1053	succinate dehydrogenase
I6J16_RS04345	COG0431	NADPH-dependent FMN reductase
I6J16_RS04380	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J16_RS04410	COG1280	lysine exporter protein (LysE YggA)
I6J16_RS04415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J16_RS04420	COG1222	aaa ATPase
I6J16_RS04430	COG4178	(ABC) transporter
I6J16_RS04440	COG0326	Molecular chaperone. Has ATPase activity
I6J16_RS04445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J16_RS04450	COG1053	succinate dehydrogenase
I6J16_RS04450	COG3976	FMN-binding domain protein
I6J16_RS04460	COG3177	Filamentation induced by cAMP protein fic
I6J16_RS04485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J16_RS04490	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS04530	COG0733	neurotransmitter:sodium symporter activity
I6J16_RS04540	COG0747	negative chemotaxis
I6J16_RS04545	COG0601	transmembrane transport
I6J16_RS04550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J16_RS04555	COG0444	Belongs to the ABC transporter superfamily
I6J16_RS04565	COG3608	succinylglutamate desuccinylase aspartoacylase
I6J16_RS04570	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6J16_RS04610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J16_RS04615	COG0626	cystathionine gamma-synthase activity
I6J16_RS04620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J16_RS04625	COG0765	amino acid transport
I6J16_RS04630	COG1126	abc transporter atp-binding protein
I6J16_RS04645	COG4566	intracellular signal transduction
I6J16_RS04650	COG3976	FMN-binding domain protein
I6J16_RS04650	COG1053	succinate dehydrogenase
I6J16_RS04655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J16_RS04670	COG3976	FMN-binding domain protein
I6J16_RS04670	COG1053	succinate dehydrogenase
I6J16_RS04705	COG1846	Transcriptional regulator
I6J16_RS04740	COG1309	transcriptional regulator
I6J16_RS04765	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS04810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J16_RS04810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J16_RS04815	COG3118	belongs to the thioredoxin family
I6J16_RS04840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J16_RS04855	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J16_RS04870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J16_RS04875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J16_RS04885	COG2801	Transposase and inactivated derivatives
I6J16_RS04890	COG0745	RESPONSE REGULATOR receiver
I6J16_RS04895	COG0642	Histidine kinase
I6J16_RS04905	COG3585	molybdate ion transport
I6J16_RS04920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J16_RS04925	COG1126	abc transporter atp-binding protein
I6J16_RS04930	COG0765	amino acid transport
I6J16_RS04950	COG0732	type I restriction modification DNA specificity domain
I6J16_RS04965	COG1396	sequence-specific DNA binding
I6J16_RS04970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J16_RS04985	COG1335	isochorismatase
I6J16_RS05015	COG1116	anion transmembrane transporter activity
I6J16_RS05030	COG2079	MmgE PrpD family protein
I6J16_RS05035	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J16_RS05040	COG1027	Aspartate ammonia-lyase
I6J16_RS05060	COG0583	DNA-binding transcription factor activity
I6J16_RS05070	COG0765	amino acid transport
I6J16_RS05075	COG0765	amino acid transport
I6J16_RS05080	COG1126	abc transporter atp-binding protein
I6J16_RS05090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J16_RS05095	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS05110	COG2964	Protein conserved in bacteria
I6J16_RS05125	COG0066	3-isopropylmalate dehydratase activity
I6J16_RS05130	COG1053	succinate dehydrogenase
I6J16_RS05155	COG0642	Histidine kinase
I6J16_RS05160	COG0745	RESPONSE REGULATOR receiver
I6J16_RS05165	COG2194	sulfuric ester hydrolase activity
I6J16_RS05190	COG1773	rubredoxin
I6J16_RS05200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J16_RS05225	COG0444	Belongs to the ABC transporter superfamily
I6J16_RS05235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J16_RS05240	COG0601	transmembrane transport
I6J16_RS05245	COG2226	methyltransferase
I6J16_RS05245	COG1073	alpha beta
I6J16_RS05250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J16_RS05260	COG0347	Belongs to the P(II) protein family
I6J16_RS05265	COG0004	ammonium transporteR
I6J16_RS05275	COG2032	superoxide dismutase activity
I6J16_RS05280	COG3015	lipoprotein NlpE involved in copper resistance
I6J16_RS05290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J16_RS05295	COG4208	sulfate ABC transporter
I6J16_RS05305	COG4150	thiosulfate binding
I6J16_RS05310	COG0252	asparaginase activity
I6J16_RS05325	COG1053	succinate dehydrogenase
I6J16_RS05330	COG2205	protein histidine kinase activity
I6J16_RS05335	COG4566	intracellular signal transduction
I6J16_RS05345	COG0437	4 iron, 4 sulfur cluster binding
I6J16_RS05350	COG0243	molybdopterin cofactor binding
I6J16_RS05355	COG1227	inorganic diphosphatase activity
I6J16_RS05360	COG1970	mechanosensitive ion channel activity
I6J16_RS05370	COG3366	ferrous iron transmembrane transporter activity
I6J16_RS05375	COG0697	spore germination
I6J16_RS05405	COG1131	(ABC) transporter
I6J16_RS05410	COG0842	Transport permease protein
I6J16_RS05415	COG0842	Transport permease protein
I6J16_RS05425	COG1473	amidohydrolase
I6J16_RS05430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J16_RS05435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J16_RS05440	COG2819	hydrolase of the alpha beta superfamily
I6J16_RS05460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J16_RS05475	COG2040	homocysteine
I6J16_RS05480	COG1464	Belongs to the NlpA lipoprotein family
I6J16_RS05500	COG2011	ABC-type metal ion transport system permease component
I6J16_RS05505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J16_RS05510	COG1473	amidohydrolase
I6J16_RS05525	COG1053	succinate dehydrogenase
I6J16_RS05580	COG1053	succinate dehydrogenase
I6J16_RS05580	COG3976	FMN-binding domain protein
I6J16_RS05595	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J16_RS05600	COG0583	DNA-binding transcription factor activity
I6J16_RS05605	COG2954	triphosphatase activity
I6J16_RS05615	COG0700	Nucleoside recognition
I6J16_RS05620	COG3366	ferrous iron transmembrane transporter activity
I6J16_RS05645	COG0165	Argininosuccinate lyase
I6J16_RS05655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J16_RS05660	COG0505	Belongs to the CarA family
I6J16_RS05685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J16_RS05695	COG1473	amidohydrolase
I6J16_RS05710	COG2356	endonuclease I
I6J16_RS05735	COG1028	Short-chain dehydrogenase reductase Sdr
I6J16_RS05740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J16_RS05760	COG0583	DNA-binding transcription factor activity
I6J16_RS05765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J16_RS05770	COG0165	Argininosuccinate lyase
I6J16_RS05770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J16_RS05815	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J16_RS05840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J16_RS05850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6J16_RS05850	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J16_RS05865	COG0107	imidazoleglycerol-phosphate synthase activity
I6J16_RS05875	COG0436	Aminotransferase
I6J16_RS05880	COG3527	Alpha-acetolactate decarboxylase
I6J16_RS05890	COG2119	membrane
I6J16_RS05900	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J16_RS05905	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J16_RS05920	COG1280	lysine exporter protein (LysE YggA)
I6J16_RS05930	COG1566	PFAM secretion protein HlyD family protein
I6J16_RS05960	COG1918	ferrous iron import across plasma membrane
I6J16_RS05975	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS05985	COG1301	dicarboxylic acid transport
I6J16_RS06000	COG0564	pseudouridine synthase activity
I6J16_RS06005	COG2217	Heavy metal translocating P-type atpase
I6J16_RS06025	COG0642	Histidine kinase
I6J16_RS06030	COG4566	intracellular signal transduction
I6J16_RS06035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J16_RS06075	COG1122	ATPase activity
I6J16_RS06080	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6J16_RS06090	COG4221	oxidoreductase activity
I6J16_RS06095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J16_RS06105	COG1473	amidohydrolase
I6J16_RS06110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J16_RS06115	COG1215	transferase activity, transferring glycosyl groups
I6J16_RS06135	COG1215	transferase activity, transferring glycosyl groups
I6J16_RS06140	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6J16_RS06145	COG2194	sulfuric ester hydrolase activity
I6J16_RS06160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J16_RS06165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J16_RS06185	COG1473	amidohydrolase
I6J16_RS06190	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS06205	COG1757	Na H antiporter
I6J16_RS06215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J16_RS06230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J16_RS06235	COG3875	lactate racemase activity
I6J16_RS06265	COG0848	biopolymer transport protein
I6J16_RS06270	COG0811	peptide transport
I6J16_RS06275	COG4771	TonB-dependent receptor
I6J16_RS06280	COG4771	TonB-dependent receptor
I6J16_RS06285	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J16_RS06290	COG4605	iron ion homeostasis
I6J16_RS06295	COG4604	ABC transporter, ATP-binding protein
I6J16_RS06300	COG4607	ABC-type enterochelin transport system periplasmic component
I6J16_RS06315	COG0667	Aldo Keto reductase
I6J16_RS06335	COG2814	Major facilitator Superfamily
I6J16_RS06350	COG1966	Carbon starvation protein
I6J16_RS06355	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS06360	COG2807	transmembrane transport
I6J16_RS06375	COG2911	Protein conserved in bacteria
I6J16_RS06380	COG0729	surface antigen
I6J16_RS06425	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6J16_RS06435	COG1309	transcriptional regulator
I6J16_RS06440	COG2814	Major facilitator Superfamily
I6J16_RS06450	COG3842	ATPase activity
I6J16_RS06455	COG1175	transmembrane transport
I6J16_RS06465	COG1653	transport
I6J16_RS06480	COG0129	dihydroxy-acid dehydratase activity
I6J16_RS06500	COG0037	tRNA processing
I6J16_RS06510	COG1053	succinate dehydrogenase
I6J16_RS06515	COG0471	metal ion transport
I6J16_RS06560	COG1053	succinate dehydrogenase
I6J16_RS06575	COG1053	succinate dehydrogenase
I6J16_RS06585	COG0758	DNA mediated transformation
I6J16_RS06595	COG0560	Phosphoserine phosphatase
I6J16_RS06600	COG0456	acetyltransferase
I6J16_RS06605	COG0612	Peptidase, M16
I6J16_RS06610	COG2917	probably involved in intracellular septation
I6J16_RS06615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J16_RS06620	COG0656	L-ascorbic acid biosynthetic process
I6J16_RS06635	COG4149	molybdate abc transporter
I6J16_RS06645	COG1295	ribonuclease BN
I6J16_RS06665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J16_RS06690	COG0531	amino acid
I6J16_RS06695	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6J16_RS06700	COG1846	Transcriptional regulator
I6J16_RS06725	COG4126	flavin adenine dinucleotide binding
I6J16_RS06735	COG0656	L-ascorbic acid biosynthetic process
I6J16_RS06740	COG1464	Belongs to the NlpA lipoprotein family
I6J16_RS06745	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J16_RS06750	COG1121	(ABC) transporter
I6J16_RS06755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J16_RS06765	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J16_RS06780	COG4566	intracellular signal transduction
I6J16_RS06785	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6J16_RS06795	COG1017	nitric oxide dioxygenase activity
I6J16_RS06795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J16_RS06800	COG1959	2 iron, 2 sulfur cluster binding
I6J16_RS06805	COG5002	protein histidine kinase activity
I6J16_RS06810	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J16_RS06815	COG0590	tRNA wobble adenosine to inosine editing
I6J16_RS06830	COG1979	alcohol dehydrogenase
I6J16_RS06835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J16_RS06840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J16_RS06845	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J16_RS06855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J16_RS06860	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J16_RS06885	COG0483	inositol monophosphate 1-phosphatase activity
I6J16_RS06900	COG1053	succinate dehydrogenase
I6J16_RS06920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J16_RS06930	COG0242	peptide deformylase activity
I6J16_RS06940	COG4191	Histidine kinase
I6J16_RS06950	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J16_RS06955	COG0488	(ABC) transporter
I6J16_RS06970	COG0728	peptidoglycan biosynthetic process
I6J16_RS06975	COG0268	Binds directly to 16S ribosomal RNA
I6J16_RS06980	COG1053	succinate dehydrogenase
I6J16_RS06980	COG3976	FMN-binding domain protein
I6J16_RS06985	COG1272	protein, Hemolysin III
I6J16_RS06990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J16_RS06995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J16_RS07000	COG0142	geranyltranstransferase activity
I6J16_RS07005	COG1722	exodeoxyribonuclease VII activity
I6J16_RS07020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J16_RS07020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J16_RS07045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6J16_RS07055	COG2878	Part of a membrane complex involved in electron transport
I6J16_RS07060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J16_RS07065	COG0431	NADPH-dependent FMN reductase
I6J16_RS07065	COG1053	succinate dehydrogenase
I6J16_RS07065	COG3976	FMN-binding domain protein
I6J16_RS07075	COG3850	Histidine kinase
I6J16_RS07110	COG1069	ribulokinase activity
I6J16_RS07145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J16_RS07150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J16_RS07160	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J16_RS07200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J16_RS07210	COG0419	ATPase involved in DNA repair
I6J16_RS07220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J16_RS07235	COG0437	4 iron, 4 sulfur cluster binding
I6J16_RS07245	COG1053	succinate dehydrogenase
I6J16_RS07250	COG1823	symporter activity
I6J16_RS07260	COG0405	Gamma-glutamyltransferase
I6J16_RS07265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J16_RS07295	COG0564	pseudouridine synthase activity
I6J16_RS07300	COG1530	ribonuclease E activity
I6J16_RS07315	COG1053	succinate dehydrogenase
I6J16_RS07315	COG3976	FMN-binding domain protein
I6J16_RS07325	COG4191	Histidine kinase
I6J16_RS07325	COG2205	protein histidine kinase activity
I6J16_RS07325	COG0745	RESPONSE REGULATOR receiver
I6J16_RS07330	COG1053	succinate dehydrogenase
I6J16_RS07350	COG0114	fumarate hydratase activity
I6J16_RS07360	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J16_RS07365	COG2079	MmgE PrpD family protein
I6J16_RS07370	COG0471	metal ion transport
I6J16_RS07385	COG2721	sulfolactate sulfo-lyase activity
I6J16_RS07405	COG0251	oxidation-reduction process
I6J16_RS07410	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS07420	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6J16_RS07440	COG4948	Mandelate Racemase Muconate Lactonizing
I6J16_RS07445	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS07460	COG0210	DNA helicase
I6J16_RS07475	COG1466	dna polymerase III delta subunit
I6J16_RS07480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J16_RS07485	COG1114	Component of the transport system for branched-chain amino acids
I6J16_RS07495	COG0371	Dehydrogenase
I6J16_RS07500	COG0335	large ribosomal subunit rRNA binding
I6J16_RS07505	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J16_RS07510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J16_RS07515	COG0228	four-way junction DNA binding
I6J16_RS07525	COG2086	electron transfer activity
I6J16_RS07540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J16_RS07545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J16_RS07560	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J16_RS07575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J16_RS07590	COG2914	Belongs to the UPF0125 (RnfH) family
I6J16_RS07595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J16_RS07600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J16_RS07605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J16_RS07610	COG1120	ATPase activity
I6J16_RS07615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J16_RS07620	COG0473	3-isopropylmalate dehydrogenase activity
I6J16_RS07625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J16_RS07630	COG0066	3-isopropylmalate dehydratase activity
I6J16_RS07635	COG1053	succinate dehydrogenase
I6J16_RS07655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J16_RS07660	COG1473	amidohydrolase
I6J16_RS07670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J16_RS07680	COG2814	Major facilitator Superfamily
I6J16_RS07725	COG2801	Transposase and inactivated derivatives
I6J16_RS07730	COG1022	Amp-dependent synthetase and ligase
I6J16_RS07735	COG1022	Amp-dependent synthetase and ligase
I6J16_RS07740	COG0516	GMP reductase activity
I6J16_RS07740	COG0517	IMP dehydrogenase activity
I6J16_RS07745	COG0519	Catalyzes the synthesis of GMP from XMP
I6J16_RS07745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J16_RS07750	COG0582	viral genome integration into host DNA
I6J16_RS07805	COG4964	Belongs to the GSP D family
I6J16_RS07840	COG0288	reversible hydration of carbon dioxide
I6J16_RS07845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J16_RS07850	COG0135	phosphoribosylanthranilate isomerase activity
I6J16_RS07850	COG0134	indole-3-glycerol-phosphate synthase activity
I6J16_RS07855	COG0133	tryptophan synthase activity
I6J16_RS07860	COG0159	tryptophan synthase activity
I6J16_RS07865	COG4145	pantothenate transmembrane transporter activity
I6J16_RS07875	COG1573	uracil-dna glycosylase
I6J16_RS07880	COG0456	acetyltransferase
I6J16_RS07885	COG1214	PFAM Peptidase M22, glycoprotease
I6J16_RS07915	COG0471	metal ion transport
I6J16_RS07920	COG0513	Belongs to the DEAD box helicase family
I6J16_RS07955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6J16_RS07960	COG4191	Histidine kinase
I6J16_RS07970	COG1053	succinate dehydrogenase
I6J16_RS07975	COG3976	FMN-binding domain protein
I6J16_RS07975	COG1053	succinate dehydrogenase
I6J16_RS07985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J16_RS07995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J16_RS08000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J16_RS08010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J16_RS08010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J16_RS08015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J16_RS08020	COG0196	riboflavin kinase activity
I6J16_RS08025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J16_RS08030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J16_RS08040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J16_RS08045	COG0756	dUTP diphosphatase activity
I6J16_RS08065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J16_RS08070	COG1570	exodeoxyribonuclease VII activity
I6J16_RS08075	COG1663	tetraacyldisaccharide 4'-kinase activity
I6J16_RS08085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6J16_RS08100	COG0747	negative chemotaxis
I6J16_RS08110	COG0563	adenylate kinase activity
I6J16_RS08115	COG0277	FAD linked oxidase domain protein
I6J16_RS08125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J16_RS08130	COG3012	SEC-C Motif Domain Protein
I6J16_RS08140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J16_RS08145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J16_RS08155	COG2251	uridine kinase activity
I6J16_RS08155	COG0195	Participates in both transcription termination and antitermination
I6J16_RS08160	COG0779	Required for maturation of 30S ribosomal subunits
I6J16_RS08170	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J16_RS08185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J16_RS08215	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6J16_RS08220	COG0167	dihydroorotate dehydrogenase activity
I6J16_RS08230	COG2181	nitrate reductase activity
I6J16_RS08230	COG0247	lactate metabolic process
I6J16_RS08235	COG1686	Belongs to the peptidase S11 family
I6J16_RS08240	COG1643	Atp-dependent helicase
I6J16_RS08245	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6J16_RS08250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6J16_RS08265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J16_RS08275	COG3829	transcription factor binding
I6J16_RS08285	COG0534	Mate efflux family protein
I6J16_RS08290	COG0833	amino acid
I6J16_RS08295	COG3457	Alanine racemase
I6J16_RS08300	COG0531	amino acid
I6J16_RS08325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J16_RS08350	COG1053	succinate dehydrogenase
I6J16_RS08355	COG4566	intracellular signal transduction
I6J16_RS08360	COG2205	protein histidine kinase activity
I6J16_RS08365	COG0710	3-dehydroquinate dehydratase activity
I6J16_RS08370	COG1053	succinate dehydrogenase
I6J16_RS08370	COG3976	FMN-binding domain protein
I6J16_RS08400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J16_RS08415	COG3852	Histidine kinase
I6J16_RS08420	COG0174	glutamine synthetase
I6J16_RS08425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J16_RS08430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J16_RS08435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6J16_RS08440	COG1561	YicC-like family, N-terminal region
I6J16_RS08450	COG1758	RNA polymerase activity
I6J16_RS08455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J16_RS08665	COG5377	YqaJ viral recombinase family
I6J16_RS08725	COG0525	valine-tRNA ligase activity
I6J16_RS08740	COG0165	Argininosuccinate lyase
I6J16_RS08760	COG1477	protein flavinylation
I6J16_RS08770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J16_RS08775	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J16_RS08780	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6J16_RS08790	COG1442	glycosyl transferase family 8
I6J16_RS08790	COG1216	Glycosyl transferase, family 2
I6J16_RS08795	COG2084	Dehydrogenase
I6J16_RS08805	COG2925	Exonuclease
I6J16_RS08820	COG0697	spore germination
I6J16_RS08825	COG1132	(ABC) transporter
I6J16_RS08840	COG1216	Glycosyl transferase, family 2
I6J16_RS08845	COG0497	DNA recombination
I6J16_RS08850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J16_RS08865	COG1388	LysM domain
I6J16_RS08865	COG0741	lytic transglycosylase activity
I6J16_RS08870	COG2226	methyltransferase
I6J16_RS08875	COG0328	RNA-DNA hybrid ribonuclease activity
I6J16_RS08895	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J16_RS08915	COG0730	response to heat
I6J16_RS08920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J16_RS08930	COG0352	thiamine-phosphate diphosphorylase activity
I6J16_RS08935	COG2194	sulfuric ester hydrolase activity
I6J16_RS08955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J16_RS08960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J16_RS08965	COG1862	Preprotein translocase
I6J16_RS08970	COG0343	queuine tRNA-ribosyltransferase activity
I6J16_RS08975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J16_RS08980	COG3028	Belongs to the UPF0307 family
I6J16_RS08985	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J16_RS09005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J16_RS09010	COG0617	tRNA 3'-terminal CCA addition
I6J16_RS09020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6J16_RS09025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J16_RS09030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J16_RS09035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J16_RS09040	COG0586	Pfam SNARE associated Golgi protein
I6J16_RS09045	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6J16_RS09050	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J16_RS09055	COG0126	phosphoglycerate kinase activity
I6J16_RS09060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J16_RS09065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J16_RS09070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J16_RS09085	COG2239	Acts as a magnesium transporter
I6J16_RS09090	COG0557	exoribonuclease II activity
I6J16_RS09095	COG3150	esterase
I6J16_RS09100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J16_RS09110	COG0511	ligase activity, forming carbon-carbon bonds
I6J16_RS09115	COG0439	Biotin carboxylase
I6J16_RS09120	COG2264	protein methyltransferase activity
I6J16_RS09135	COG0762	integral membrane protein
I6J16_RS09155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J16_RS09160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6J16_RS09165	COG0632	four-way junction helicase activity
I6J16_RS09170	COG2255	four-way junction helicase activity
I6J16_RS09175	COG0252	asparaginase activity
I6J16_RS09180	COG2843	Capsule synthesis protein
I6J16_RS09185	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J16_RS09190	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J16_RS09205	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6J16_RS09235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J16_RS09240	COG0601	transmembrane transport
I6J16_RS09250	COG0824	Thioesterase
I6J16_RS09260	COG0848	biopolymer transport protein
I6J16_RS09270	COG0442	prolyl-tRNA aminoacylation
I6J16_RS09275	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J16_RS09280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J16_RS09285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J16_RS09290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J16_RS09295	COG0142	geranyltranstransferase activity
I6J16_RS09305	COG0237	dephospho-CoA kinase activity
I6J16_RS09315	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6J16_RS09320	COG0494	nUDIX hydrolase
I6J16_RS09335	COG0653	protein targeting
I6J16_RS09345	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6J16_RS09350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J16_RS09360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J16_RS09365	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J16_RS09370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J16_RS09375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J16_RS09385	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J16_RS09390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J16_RS09395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J16_RS09400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J16_RS09415	COG0275	rRNA processing
I6J16_RS09420	COG2001	Belongs to the MraZ family
I6J16_RS09440	COG4232	protein-disulfide reductase activity
I6J16_RS09445	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J16_RS09450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J16_RS09465	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J16_RS09480	COG1253	flavin adenine dinucleotide binding
I6J16_RS09490	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J16_RS09500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J16_RS09510	COG1785	Belongs to the alkaline phosphatase family
I6J16_RS09520	COG1136	(ABC) transporter
I6J16_RS09530	COG1902	pentaerythritol trinitrate reductase activity
I6J16_RS09535	COG0307	riboflavin synthase, alpha
I6J16_RS09540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J16_RS09540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J16_RS09545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J16_RS09550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J16_RS09560	COG1490	D-aminoacyl-tRNA deacylase activity
I6J16_RS09575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6J16_RS09580	COG0316	Belongs to the HesB IscA family
I6J16_RS09585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J16_RS09590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J16_RS09595	COG2095	MarC family integral membrane protein
I6J16_RS09605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J16_RS09655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J16_RS09710	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J16_RS09725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J16_RS09755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6J16_RS09765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6J16_RS09770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J16_RS09785	COG2969	positive regulation of protein catabolic process
I6J16_RS09790	COG0625	glutathione transferase activity
I6J16_RS09795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J16_RS09815	COG0805	protein transport
I6J16_RS09820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J16_RS09825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J16_RS09835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J16_RS09850	COG2853	Lipoprotein
I6J16_RS09855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J16_RS09860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J16_RS09865	COG1127	ABC transporter
I6J16_RS09880	COG1965	Belongs to the frataxin family
I6J16_RS09895	COG0516	GMP reductase activity
I6J16_RS09900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6J16_RS09910	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J16_RS09915	COG0203	ribosomal protein L17
I6J16_RS09920	COG0202	RNA polymerase activity
I6J16_RS09925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J16_RS09930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J16_RS09935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J16_RS09945	COG0201	protein transport
I6J16_RS09950	COG0200	Binds to the 23S rRNA
I6J16_RS09955	COG1841	ribosomal large subunit assembly
I6J16_RS09960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J16_RS09965	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J16_RS09970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J16_RS09975	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J16_RS09980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J16_RS09985	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J16_RS09990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J16_RS09995	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J16_RS10000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J16_RS10005	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J16_RS10010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J16_RS10020	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J16_RS10025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J16_RS10030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J16_RS10035	COG0089	rRNA binding
I6J16_RS10040	COG0088	Forms part of the polypeptide exit tunnel
I6J16_RS10045	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J16_RS10050	COG0051	transcription antitermination factor activity, RNA binding
I6J16_RS10055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J16_RS10065	COG0049	tRNA binding
I6J16_RS10070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J16_RS10075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J16_RS10080	COG0085	RNA polymerase activity
I6J16_RS10090	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J16_RS10095	COG0081	regulation of translation
I6J16_RS10100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J16_RS10110	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J16_RS10120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J16_RS10140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J16_RS10150	COG1469	GTP cyclohydrolase I activity
I6J16_RS10155	COG0018	arginyl-trna synthetase
I6J16_RS10170	COG4221	oxidoreductase activity
I6J16_RS10175	COG0514	ATP-dependent DNA helicase (RecQ)
I6J16_RS10180	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6J16_RS10195	COG0243	molybdopterin cofactor binding
I6J16_RS10200	COG0437	4 iron, 4 sulfur cluster binding
I6J16_RS10205	COG0348	domain, Protein
I6J16_RS10215	COG2197	response regulator
I6J16_RS10220	COG3850	Histidine kinase
I6J16_RS10225	COG0493	'glutamate synthase
I6J16_RS10230	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J16_RS10235	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J16_RS10240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J16_RS10245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J16_RS10255	COG2945	thiolester hydrolase activity
I6J16_RS10255	COG0596	Alpha beta hydrolase
I6J16_RS10275	COG1294	oxidase, subunit
I6J16_RS10285	COG2346	COG2346, Truncated hemoglobins
I6J16_RS10295	COG4681	YaeQ
I6J16_RS10320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J16_RS10345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J16_RS10360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J16_RS10375	COG2226	methyltransferase
I6J16_RS10425	COG0582	viral genome integration into host DNA
I6J16_RS10435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J16_RS10440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J16_RS10450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J16_RS10455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J16_RS10470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J16_RS10485	COG0356	it plays a direct role in the translocation of protons across the membrane
I6J16_RS10495	COG1475	DNA binding
I6J16_RS10500	COG1192	Involved in chromosome partitioning
I6J16_RS10510	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J16_RS10515	COG0445	tRNA wobble uridine modification
I6J16_RS10520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J16_RS10530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J16_RS10535	COG0594	ribonuclease P activity
I6J16_RS10540	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6J16_RS10545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6J16_RS10565	COG2823	Periplasmic or secreted lipoprotein
I6J16_RS10570	COG1575	Belongs to the MenA family. Type 1 subfamily
I6J16_RS10575	COG2921	Belongs to the UPF0250 family
I6J16_RS10585	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6J16_RS10585	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6J16_RS10590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J16_RS10610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J16_RS10615	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6J16_RS10620	COG0772	Belongs to the SEDS family
I6J16_RS10625	COG0768	penicillin binding
I6J16_RS10640	COG1077	Cell shape determining protein MreB Mrl
I6J16_RS10645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J16_RS10650	COG0154	amidase activity
I6J16_RS10660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J16_RS10665	COG0708	Exodeoxyribonuclease III
I6J16_RS10685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J16_RS10690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J16_RS10705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J16_RS10710	COG0569	domain protein
I6J16_RS10715	COG2204	response regulator
I6J16_RS10720	COG5000	phosphorelay sensor kinase activity
I6J16_RS10730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J16_RS10730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J16_RS10735	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J16_RS10740	COG2267	carboxylic ester hydrolase activity
I6J16_RS10745	COG0242	peptide deformylase activity
I6J16_RS10760	COG1253	flavin adenine dinucleotide binding
I6J16_RS10765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J16_RS10770	COG4597	amino acid ABC transporter
I6J16_RS10775	COG0765	amino acid transport
I6J16_RS10785	COG2183	response to ionizing radiation
I6J16_RS10790	COG2233	PERMEase
I6J16_RS10795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J16_RS10800	COG1160	GTP binding
I6J16_RS10815	COG4624	Iron only hydrogenase large subunit, C-terminal domain
I6J16_RS10815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J16_RS10820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J16_RS10825	COG1022	Amp-dependent synthetase and ligase
I6J16_RS10830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J16_RS10845	COG0488	(ABC) transporter
I6J16_RS10850	COG3107	peptidoglycan biosynthetic process
I6J16_RS10855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J16_RS10860	COG2326	polyphosphate kinase activity
I6J16_RS10870	COG0516	GMP reductase activity
I6J16_RS10870	COG0517	IMP dehydrogenase activity
I6J16_RS10890	COG0617	tRNA 3'-terminal CCA addition
I6J16_RS10895	COG0741	lytic transglycosylase activity
I6J16_RS10905	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J16_RS10915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J16_RS10925	COG1560	Kdo2-lipid A biosynthetic process
I6J16_RS10930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6J16_RS10935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J16_RS10940	COG0523	cobalamin synthesis protein
I6J16_RS10955	COG0493	'glutamate synthase
I6J16_RS10955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J16_RS10965	COG3381	protein complex oligomerization
I6J16_RS10975	COG0437	4 iron, 4 sulfur cluster binding
I6J16_RS10995	COG0616	signal peptide processing
I6J16_RS11000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J16_RS11005	COG0793	Belongs to the peptidase S41A family
I6J16_RS11015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J16_RS11020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6J16_RS11025	COG2197	response regulator
I6J16_RS11030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J16_RS11035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J16_RS11045	COG2884	Cell division ATP-binding protein ftsE
I6J16_RS11050	COG0248	Ppx GppA phosphatase
I6J16_RS11060	COG0742	ribosomal rna small subunit methyltransferase
I6J16_RS11075	COG3634	alkyl hydroperoxide reductase activity
I6J16_RS11090	COG0012	GTP binding
I6J16_RS11100	COG0193	aminoacyl-tRNA hydrolase activity
I6J16_RS11105	COG0513	Belongs to the DEAD box helicase family
I6J16_RS11115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J16_RS11120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J16_RS11130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J16_RS11135	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6J16_RS11145	COG2205	protein histidine kinase activity
I6J16_RS11155	COG1660	Displays ATPase and GTPase activities
I6J16_RS11160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J16_RS11165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6J16_RS11170	COG1137	ATPase activity
I6J16_RS11185	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6J16_RS11190	COG0517	IMP dehydrogenase activity
I6J16_RS11190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J16_RS11195	COG1126	abc transporter atp-binding protein
I6J16_RS11200	COG0765	amino acid transport
I6J16_RS11205	COG0765	amino acid transport
I6J16_RS11220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J16_RS11220	COG1042	CoA-binding domain protein
I6J16_RS11220	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J16_RS11225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6J16_RS11230	COG0235	Class ii aldolase
I6J16_RS11255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J16_RS11275	COG0745	RESPONSE REGULATOR receiver
I6J16_RS11290	COG1136	(ABC) transporter
I6J16_RS11295	COG1136	(ABC) transporter
I6J16_RS11295	COG0577	efflux transmembrane transporter activity
I6J16_RS11305	COG2814	Major facilitator Superfamily
I6J16_RS11310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J16_RS11315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J16_RS11320	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J16_RS11335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J16_RS11350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J16_RS11355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J16_RS11365	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J16_RS11380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6J16_RS11395	COG0859	PFAM glycosyl transferase family 9
I6J16_RS11420	COG1702	phosphate starvation-inducible protein PhoH
I6J16_RS11425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J16_RS11430	COG4535	Mg2 and Co2 transporter CorC
I6J16_RS11440	COG0752	glycyl-tRNA synthetase alpha subunit
I6J16_RS11445	COG0751	glycine-tRNA ligase activity
I6J16_RS11460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J16_RS11465	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J16_RS11470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J16_RS11475	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6J16_RS11485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J16_RS11490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J16_RS11500	COG0138	bifunctional purine biosynthesis protein purh
I6J16_RS11505	COG0823	Involved in the tonB-independent uptake of proteins
I6J16_RS11520	COG0281	malic enzyme
I6J16_RS11530	COG0659	secondary active sulfate transmembrane transporter activity
I6J16_RS11535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J16_RS11535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J16_RS11545	COG0489	protein tyrosine kinase activity
I6J16_RS11550	COG0492	ferredoxin-NADP+ reductase activity
I6J16_RS11555	COG4783	chaperone-mediated protein folding
I6J16_RS11565	COG2197	response regulator
I6J16_RS11570	COG0589	response to stress
I6J16_RS11585	COG4991	sh3 domain protein
I6J16_RS11585	COG3064	Membrane
I6J16_RS11585	COG0515	serine threonine protein kinase
I6J16_RS11590	COG0488	(ABC) transporter
I6J16_RS11600	COG0653	protein targeting
I6J16_RS11605	COG1968	undecaprenyl-diphosphatase activity
I6J16_RS11610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J16_RS11615	COG2011	ABC-type metal ion transport system permease component
I6J16_RS11620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J16_RS11660	COG0861	Integral membrane protein TerC family
I6J16_RS11665	COG0482	sulfurtransferase activity
I6J16_RS11670	COG2070	2-Nitropropane dioxygenase
I6J16_RS11675	COG1346	cytolysis
I6J16_RS11700	COG0318	PFAM AMP-dependent synthetase and ligase
I6J16_RS11710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J16_RS11730	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J16_RS11750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J16_RS11755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J16_RS11760	COG0443	Heat shock 70 kDa protein
I6J16_RS11765	COG0484	heat shock protein binding
I6J16_RS11775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J16_RS11780	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J16_RS11785	COG2197	response regulator
I6J16_RS11790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J16_RS11795	COG1473	amidohydrolase
I6J16_RS11800	COG0217	transcriptional regulatory protein
I6J16_RS11815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J16_RS11820	COG0799	negative regulation of ribosome biogenesis
I6J16_RS11825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6J16_RS11830	COG0424	maF-like protein
I6J16_RS11860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J16_RS11870	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6J16_RS11875	COG0308	aminopeptidase N
I6J16_RS11880	COG3005	denitrification pathway
I6J16_RS11900	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6J16_RS11935	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6J16_RS11945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J16_RS11960	COG0009	L-threonylcarbamoyladenylate synthase
I6J16_RS11965	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J16_RS11970	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J16_RS11975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J16_RS11990	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J16_RS11995	COG0802	atpase or kinase
I6J16_RS12035	COG0437	4 iron, 4 sulfur cluster binding
I6J16_RS12055	COG1288	antiporter activity
I6J16_RS12065	COG1953	Uracil, thiamine, allantoin
I6J16_RS12070	COG3257	ureidoglycine aminohydrolase activity
I6J16_RS12080	COG0549	Belongs to the carbamate kinase family
I6J16_RS12105	COG0402	S-adenosylhomocysteine deaminase activity
I6J16_RS12115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6J16_RS12120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J16_RS12130	COG0776	regulation of translation
I6J16_RS12135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J16_RS12140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6J16_RS12145	COG0501	Belongs to the peptidase M48B family
I6J16_RS12150	COG0252	asparaginase activity
I6J16_RS12155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J16_RS12155	COG0731	radical SAM domain protein
I6J16_RS12160	COG0534	Mate efflux family protein
I6J16_RS12170	COG0254	rRNA binding
I6J16_RS12175	COG0181	hydroxymethylbilane synthase activity
I6J16_RS12185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J16_RS12190	COG3118	belongs to the thioredoxin family
I6J16_RS12200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J16_RS12220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J16_RS12225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6J16_RS12230	COG2910	NAD(P)H-binding
I6J16_RS12235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J16_RS12240	COG1534	Rna-binding protein
I6J16_RS12245	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6J16_RS12250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J16_RS12255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J16_RS12260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J16_RS12270	COG0347	Belongs to the P(II) protein family
I6J16_RS12275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J16_RS12280	COG2860	membrane
I6J16_RS12290	COG0492	ferredoxin-NADP+ reductase activity
I6J16_RS12295	COG1674	ftsk spoiiie
I6J16_RS12300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6J16_RS12310	COG2129	metallophosphoesterase
I6J16_RS12320	COG0303	'Molybdopterin