locus-tag	class	description
L0B52_RS00005	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L0B52_RS00010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L0B52_RS00015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L0B52_RS00025	COG0723	plastoquinol--plastocyanin reductase activity
L0B52_RS00030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L0B52_RS00035	COG2857	Cytochrome c1
L0B52_RS00040	COG0625	glutathione transferase activity
L0B52_RS00060	COG0537	adenosine 5'-monophosphoramidase activity
L0B52_RS00065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L0B52_RS00075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L0B52_RS00080	COG0716	FMN binding
L0B52_RS00085	COG2814	Major facilitator Superfamily
L0B52_RS00105	COG0107	imidazoleglycerol-phosphate synthase activity
L0B52_RS00110	COG0512	Glutamine amidotransferase of anthranilate synthase
L0B52_RS00115	COG0183	Belongs to the thiolase family
L0B52_RS00120	COG3842	ATPase activity
L0B52_RS00140	COG0390	transport system, permease component
L0B52_RS00145	COG4608	Belongs to the ABC transporter superfamily
L0B52_RS00150	COG1823	symporter activity
L0B52_RS00155	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L0B52_RS00165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L0B52_RS00195	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L0B52_RS00200	COG1137	ATPase activity
L0B52_RS00205	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L0B52_RS00230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L0B52_RS00235	COG2001	Belongs to the MraZ family
L0B52_RS00240	COG0275	rRNA processing
L0B52_RS00260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L0B52_RS00265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L0B52_RS00270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L0B52_RS00275	COG0772	Belongs to the SEDS family
L0B52_RS00280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L0B52_RS00285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L0B52_RS00290	COG1181	Belongs to the D-alanine--D-alanine ligase family
L0B52_RS00295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L0B52_RS00310	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L0B52_RS00320	COG0287	Prephenate dehydrogenase
L0B52_RS00325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L0B52_RS00330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L0B52_RS00335	COG0539	negative regulation of cytoplasmic translation
L0B52_RS00340	COG0776	regulation of translation
L0B52_RS00350	COG1074	ATP-dependent DNA helicase activity
L0B52_RS00365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L0B52_RS00370	COG0024	Methionine aminopeptidase
L0B52_RS00375	COG0052	Belongs to the universal ribosomal protein uS2 family
L0B52_RS00380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L0B52_RS00385	COG0528	UMP kinase activity
L0B52_RS00390	COG0233	cytoplasmic translational termination
L0B52_RS00395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L0B52_RS00400	COG4589	Belongs to the CDS family
L0B52_RS00405	COG0750	zinc metalloprotease
L0B52_RS00410	COG0210	DNA helicase
L0B52_RS00440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L0B52_RS00445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L0B52_RS00450	COG1757	Na H antiporter
L0B52_RS00460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L0B52_RS00475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L0B52_RS00480	COG1663	tetraacyldisaccharide 4'-kinase activity
L0B52_RS00485	COG0584	glycerophosphoryl diester phosphodiesterase
L0B52_RS00490	COG0714	Associated with various cellular activities
L0B52_RS00495	COG1024	Enoyl-CoA hydratase
L0B52_RS00500	COG1902	pentaerythritol trinitrate reductase activity
L0B52_RS00500	COG0446	pyridine nucleotide-disulphide oxidoreductase
L0B52_RS00505	COG1469	GTP cyclohydrolase I activity
L0B52_RS00510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L0B52_RS00520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L0B52_RS00525	COG1702	phosphate starvation-inducible protein PhoH
L0B52_RS00530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L0B52_RS00535	COG2354	Protein conserved in bacteria
L0B52_RS00545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L0B52_RS00550	COG1534	Rna-binding protein
L0B52_RS00555	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L0B52_RS00595	COG1555	photosystem II stabilization
L0B52_RS00595	COG1596	polysaccharide export
L0B52_RS00605	COG1862	Preprotein translocase
L0B52_RS00610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L0B52_RS00615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L0B52_RS00625	COG4988	ABC transporter
L0B52_RS00630	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L0B52_RS00640	COG1294	oxidase, subunit
L0B52_RS00665	COG1496	oxidoreductase activity
L0B52_RS00670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L0B52_RS00680	COG0792	nuclease activity
L0B52_RS00690	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L0B52_RS00695	COG0594	ribonuclease P activity
L0B52_RS00705	COG0706	membrane insertase activity
L0B52_RS00710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L0B52_RS00720	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L0B52_RS00730	COG0793	Belongs to the peptidase S41A family
L0B52_RS00735	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L0B52_RS00740	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L0B52_RS00745	COG0508	dehydrogenase complex catalyzes the overall conversion of
L0B52_RS00750	COG0165	Argininosuccinate lyase
L0B52_RS00760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L0B52_RS00770	COG1105	Belongs to the carbohydrate kinase PfkB family
L0B52_RS00775	COG0488	(ABC) transporter
L0B52_RS00790	COG0741	lytic transglycosylase activity
L0B52_RS00795	COG0741	lytic transglycosylase activity
L0B52_RS00800	COG0739	heme binding
L0B52_RS00800	COG0741	lytic transglycosylase activity
L0B52_RS00800	COG1196	nuclear chromosome segregation
L0B52_RS00825	COG1959	2 iron, 2 sulfur cluster binding
L0B52_RS00830	COG0719	Fe-S assembly protein
L0B52_RS00835	COG0396	ATPase activity
L0B52_RS00850	COG0822	iron-sulfur transferase activity
L0B52_RS00855	COG2151	metal-sulfur cluster biosynthetic enzyme
L0B52_RS00860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L0B52_RS00865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L0B52_RS00870	COG0646	methionine synthase
L0B52_RS00870	COG1410	methionine synthase
L0B52_RS00875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L0B52_RS00895	COG0133	tryptophan synthase activity
L0B52_RS00900	COG0159	tryptophan synthase activity
L0B52_RS00905	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L0B52_RS00910	COG0285	dihydrofolate synthase activity
L0B52_RS00930	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L0B52_RS00935	COG4133	protoheme IX ABC transporter activity
L0B52_RS00950	COG0778	Nitroreductase
L0B52_RS00960	COG1138	Cytochrome C-type biogenesis protein
L0B52_RS00965	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
L0B52_RS00985	COG0525	valine-tRNA ligase activity
L0B52_RS01005	COG0009	L-threonylcarbamoyladenylate synthase
L0B52_RS01010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L0B52_RS01015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L0B52_RS01035	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L0B52_RS01040	COG0742	ribosomal rna small subunit methyltransferase
L0B52_RS01050	COG1739	Uncharacterized protein family UPF0029
L0B52_RS01055	COG0288	reversible hydration of carbon dioxide
L0B52_RS01110	COG1704	LemA family
L0B52_RS01125	COG0582	viral genome integration into host DNA
L0B52_RS01160	COG0730	response to heat
L0B52_RS01165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L0B52_RS01175	COG2983	Belongs to the UPF0260 family
L0B52_RS01180	COG3115	cell septum assembly
L0B52_RS01185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L0B52_RS01190	COG0009	L-threonylcarbamoyladenylate synthase
L0B52_RS01205	COG0400	carboxylic ester hydrolase activity
L0B52_RS01220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L0B52_RS01225	COG0066	3-isopropylmalate dehydratase activity
L0B52_RS01230	COG0473	3-isopropylmalate dehydrogenase activity
L0B52_RS01240	COG0101	tRNA pseudouridine synthase activity
L0B52_RS01245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L0B52_RS01245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L0B52_RS01250	COG0791	NLP P60 protein
L0B52_RS01260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L0B52_RS01270	COG0573	inorganic phosphate transmembrane transporter activity
L0B52_RS01285	COG0252	asparaginase activity
L0B52_RS01290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L0B52_RS01290	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L0B52_RS01300	COG2807	transmembrane transport
L0B52_RS01315	COG1278	Cold shock
L0B52_RS01325	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L0B52_RS01340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L0B52_RS01350	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L0B52_RS01360	COG0681	Belongs to the peptidase S26 family
L0B52_RS01365	COG0481	GTPase activity
L0B52_RS01370	COG1674	ftsk spoiiie
L0B52_RS01370	COG0531	amino acid
L0B52_RS01375	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L0B52_RS01380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L0B52_RS01385	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L0B52_RS01395	COG2832	Protein of unknown function (DUF454)
L0B52_RS01415	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L0B52_RS01420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L0B52_RS01425	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L0B52_RS01430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L0B52_RS01435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L0B52_RS01455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L0B52_RS01460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L0B52_RS01465	COG0039	L-malate dehydrogenase activity
L0B52_RS01470	COG2267	carboxylic ester hydrolase activity
L0B52_RS01475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L0B52_RS01480	COG0606	chelatase, subunit chli
L0B52_RS01485	COG2252	PERMEase
L0B52_RS01490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L0B52_RS01515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L0B52_RS01520	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
L0B52_RS01550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L0B52_RS01555	COG1131	(ABC) transporter
L0B52_RS01560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L0B52_RS01565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L0B52_RS01575	COG2226	methyltransferase
L0B52_RS01605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L0B52_RS01610	COG0708	Exodeoxyribonuclease III
L0B52_RS01625	COG0058	SHG alpha-glucan phosphorylase activity
L0B52_RS01635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L0B52_RS01640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L0B52_RS01645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L0B52_RS01650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L0B52_RS01655	COG2251	uridine kinase activity
L0B52_RS01655	COG0195	Participates in both transcription termination and antitermination
L0B52_RS01660	COG0779	Required for maturation of 30S ribosomal subunits
L0B52_RS01680	COG2304	oxidoreductase activity
L0B52_RS01690	COG3258	Cytochrome c
L0B52_RS01695	COG2863	cytochrome
L0B52_RS01700	COG0405	Gamma-glutamyltransferase
L0B52_RS01705	COG0659	secondary active sulfate transmembrane transporter activity
L0B52_RS01710	COG0589	response to stress
L0B52_RS01720	COG0408	coproporphyrinogen oxidase activity
L0B52_RS01725	COG0519	Catalyzes the synthesis of GMP from XMP
L0B52_RS01725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L0B52_RS01750	COG0616	signal peptide processing
L0B52_RS01755	COG0564	pseudouridine synthase activity
L0B52_RS01765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L0B52_RS01785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L0B52_RS01790	COG0557	exoribonuclease II activity
L0B52_RS01795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L0B52_RS01800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
L0B52_RS01810	COG0330	HflC and HflK could
L0B52_RS01815	COG0330	HflC and HflK could
L0B52_RS01820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L0B52_RS01825	COG1923	regulation of RNA biosynthetic process
L0B52_RS01830	COG4589	Belongs to the CDS family
L0B52_RS01840	COG2267	carboxylic ester hydrolase activity
L0B52_RS01845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L0B52_RS01850	COG0490	domain, Protein
L0B52_RS01850	COG0471	metal ion transport
L0B52_RS01870	COG2830	Protein of unknown function (DUF452)
L0B52_RS01875	COG0156	8-amino-7-oxononanoate synthase activity
L0B52_RS01880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L0B52_RS01885	COG0556	nucleotide-excision repair
L0B52_RS01890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L0B52_RS01900	COG0509	glycine decarboxylation via glycine cleavage system
L0B52_RS01905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L0B52_RS01915	COG4215	(ABC) transporter
L0B52_RS01920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L0B52_RS01930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L0B52_RS01940	COG1764	response to oxidative stress
L0B52_RS01945	COG1304	FMN binding
L0B52_RS01950	COG0860	N-Acetylmuramoyl-L-alanine amidase
L0B52_RS01955	COG0802	atpase or kinase
L0B52_RS01965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L0B52_RS01970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L0B52_RS01975	COG0167	dihydroorotate dehydrogenase activity
L0B52_RS01980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L0B52_RS02000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L0B52_RS02010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L0B52_RS02015	COG0497	DNA recombination
L0B52_RS02025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L0B52_RS02030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L0B52_RS02035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L0B52_RS02040	COG0196	riboflavin kinase activity
L0B52_RS02050	COG0671	phosphoesterase, PA-phosphatase related
L0B52_RS02050	COG2453	phosphatase
L0B52_RS02055	COG0418	dihydroorotase activity
L0B52_RS02065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L0B52_RS02070	COG0542	response to heat
L0B52_RS02075	COG4221	oxidoreductase activity
L0B52_RS02080	COG0300	oxidoreductase activity
L0B52_RS02085	COG1012	belongs to the aldehyde dehydrogenase family
L0B52_RS02090	COG2195	Cleaves the N-terminal amino acid of tripeptides
L0B52_RS02095	COG0616	signal peptide processing
L0B52_RS02115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L0B52_RS02120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L0B52_RS02135	COG1472	Belongs to the glycosyl hydrolase 3 family
L0B52_RS02145	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L0B52_RS02165	COG0583	DNA-binding transcription factor activity
L0B52_RS02170	COG0667	Aldo Keto reductase
L0B52_RS02180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L0B52_RS02185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L0B52_RS02200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L0B52_RS02200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L0B52_RS02205	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L0B52_RS02210	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L0B52_RS02215	COG1984	allophanate hydrolase subunit 2
L0B52_RS02220	COG0318	PFAM AMP-dependent synthetase and ligase
L0B52_RS02240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L0B52_RS02250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L0B52_RS02255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L0B52_RS02260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L0B52_RS02265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L0B52_RS02280	COG0312	modulator of DNA gyrase
L0B52_RS02285	COG0312	modulator of DNA gyrase
L0B52_RS02305	COG1214	PFAM Peptidase M22, glycoprotease
L0B52_RS02310	COG1199	ATP-dependent helicase activity
L0B52_RS02320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L0B52_RS02335	COG1830	Aldolase
L0B52_RS02350	COG1183	phosphatidylcholine synthase activity
L0B52_RS02355	COG0284	orotidine-5'-phosphate decarboxylase activity
L0B52_RS02360	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
L0B52_RS02365	COG5416	Lipopolysaccharide assembly protein A domain
L0B52_RS02370	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L0B52_RS02375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L0B52_RS02385	COG0352	thiamine-phosphate diphosphorylase activity
L0B52_RS02400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L0B52_RS02400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L0B52_RS02440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L0B52_RS02445	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L0B52_RS02460	COG0297	glycogen (starch) synthase activity
L0B52_RS02465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L0B52_RS02470	COG1523	belongs to the glycosyl hydrolase 13 family
L0B52_RS02480	COG1196	nuclear chromosome segregation
L0B52_RS02495	COG0187	DNA topoisomerase II activity
L0B52_RS02510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L0B52_RS02515	COG0762	integral membrane protein
L0B52_RS02520	COG0445	tRNA wobble uridine modification
L0B52_RS02540	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L0B52_RS02550	COG0187	DNA topoisomerase II activity
L0B52_RS02560	COG0010	Belongs to the arginase family
L0B52_RS02575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L0B52_RS02585	COG1166	arginine decarboxylase activity
L0B52_RS02590	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
L0B52_RS02615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L0B52_RS02625	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L0B52_RS02630	COG4597	amino acid ABC transporter
L0B52_RS02635	COG0765	amino acid transport
L0B52_RS02640	COG1126	abc transporter atp-binding protein
L0B52_RS02645	COG1881	PFAM PEBP family protein
L0B52_RS02650	COG2914	Belongs to the UPF0125 (RnfH) family
L0B52_RS02655	COG2867	negative regulation of translational initiation
L0B52_RS02660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L0B52_RS02680	COG1289	transmembrane transporter activity
L0B52_RS02695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L0B52_RS02700	COG2011	ABC-type metal ion transport system permease component
L0B52_RS02705	COG1464	Belongs to the NlpA lipoprotein family
L0B52_RS02710	COG1063	alcohol dehydrogenase
L0B52_RS02715	COG4604	ABC transporter, ATP-binding protein
L0B52_RS02720	COG4605	iron ion homeostasis
L0B52_RS02725	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0B52_RS02735	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L0B52_RS02740	COG0848	biopolymer transport protein
L0B52_RS02760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0B52_RS02765	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
L0B52_RS02770	COG2326	polyphosphate kinase activity
L0B52_RS02790	COG0667	Aldo Keto reductase
L0B52_RS02795	COG0210	DNA helicase
L0B52_RS02800	COG0181	hydroxymethylbilane synthase activity
L0B52_RS02825	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L0B52_RS02830	COG1376	ErfK ybiS ycfS ynhG family protein
L0B52_RS02830	COG1388	LysM domain
L0B52_RS02835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L0B52_RS02840	COG0300	oxidoreductase activity
L0B52_RS02845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L0B52_RS02850	COG1858	cytochrome C peroxidase
L0B52_RS02875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L0B52_RS02910	COG0254	rRNA binding
L0B52_RS02925	COG0328	RNA-DNA hybrid ribonuclease activity
L0B52_RS02935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L0B52_RS02950	COG0438	transferase activity, transferring glycosyl groups
L0B52_RS02960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L0B52_RS02965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L0B52_RS02970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L0B52_RS02975	COG0617	tRNA 3'-terminal CCA addition
L0B52_RS02980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L0B52_RS02985	COG0070	glutamate synthase
L0B52_RS02985	COG0069	glutamate synthase activity
L0B52_RS02985	COG0067	glutamate synthase
L0B52_RS02990	COG1132	(ABC) transporter
L0B52_RS03025	COG0552	protein localization to endoplasmic reticulum
L0B52_RS03030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L0B52_RS03035	COG0735	belongs to the Fur family
L0B52_RS03040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L0B52_RS03045	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L0B52_RS03045	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L0B52_RS03050	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L0B52_RS03060	COG4773	Receptor
L0B52_RS03075	COG0500	methyltransferase
L0B52_RS03085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L0B52_RS03095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L0B52_RS03100	COG3118	belongs to the thioredoxin family
L0B52_RS03105	COG0494	nUDIX hydrolase
L0B52_RS03110	COG0653	protein targeting
L0B52_RS03125	COG0625	glutathione transferase activity
L0B52_RS03170	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L0B52_RS03175	COG4172	Belongs to the ABC transporter superfamily
L0B52_RS03180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L0B52_RS03185	COG0601	transmembrane transport
L0B52_RS03190	COG4166	transmembrane transport
L0B52_RS03195	COG0126	phosphoglycerate kinase activity
L0B52_RS03200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L0B52_RS03205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L0B52_RS03215	COG0798	PFAM Bile acid sodium symporter
L0B52_RS03230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L0B52_RS03235	COG2363	Small membrane protein
L0B52_RS03245	COG0563	adenylate kinase activity
L0B52_RS03250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L0B52_RS03255	COG1444	tRNA N-acetyltransferase activity
L0B52_RS03270	COG1444	tRNA N-acetyltransferase activity
L0B52_RS03285	COG3830	Belongs to the UPF0237 family
L0B52_RS03285	COG0560	Phosphoserine phosphatase
L0B52_RS03295	COG0850	regulation of cytokinetic process
L0B52_RS03300	COG2894	cell division
L0B52_RS03305	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
L0B52_RS03320	COG1335	isochorismatase
L0B52_RS03325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L0B52_RS03330	COG0151	Belongs to the GarS family
L0B52_RS03345	COG0194	GDP metabolic process
L0B52_RS03360	COG3079	Belongs to the UPF0149 family
L0B52_RS03375	COG0228	four-way junction DNA binding
L0B52_RS03380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L0B52_RS03385	COG0336	Belongs to the RNA methyltransferase TrmD family
L0B52_RS03390	COG0335	large ribosomal subunit rRNA binding
L0B52_RS03425	COG1053	succinate dehydrogenase
L0B52_RS03430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L0B52_RS03435	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
L0B52_RS03450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L0B52_RS03490	COG2197	response regulator
L0B52_RS03495	COG3850	Histidine kinase
L0B52_RS03520	COG0004	ammonium transporteR
L0B52_RS03535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L0B52_RS03540	COG2226	methyltransferase
L0B52_RS03545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L0B52_RS03560	COG4968	Prepilin-type N-terminal cleavage methylation domain
L0B52_RS03585	COG0343	queuine tRNA-ribosyltransferase activity
L0B52_RS03605	COG2358	TRAP transporter, solute receptor (TAXI family
L0B52_RS03610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L0B52_RS03615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L0B52_RS03620	COG0662	Cupin 2, conserved barrel domain protein
L0B52_RS03625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L0B52_RS03630	COG1522	sequence-specific DNA binding
L0B52_RS03645	COG0567	Dehydrogenase, E1 component
L0B52_RS03650	COG2358	TRAP transporter, solute receptor (TAXI family
L0B52_RS03655	COG0799	negative regulation of ribosome biogenesis
L0B52_RS03660	COG0095	Lipoate-protein ligase
L0B52_RS03670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L0B52_RS03675	COG1121	(ABC) transporter
L0B52_RS03680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L0B52_RS03685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L0B52_RS03690	COG0488	(ABC) transporter
L0B52_RS03700	COG1757	Na H antiporter
L0B52_RS03705	COG0697	spore germination
L0B52_RS03715	COG0574	Belongs to the PEP-utilizing enzyme family
L0B52_RS03715	COG3848	Pyruvate phosphate dikinase
L0B52_RS03730	COG5383	Protein conserved in bacteria
L0B52_RS03740	COG4221	oxidoreductase activity
L0B52_RS03760	COG0316	Belongs to the HesB IscA family
L0B52_RS03765	COG1104	cysteine desulfurase activity
L0B52_RS03770	COG1045	serine acetyltransferase
L0B52_RS03775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L0B52_RS03780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L0B52_RS03790	COG0351	phosphomethylpyrimidine kinase
L0B52_RS03795	COG1116	anion transmembrane transporter activity
L0B52_RS03800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L0B52_RS03815	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L0B52_RS03820	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L0B52_RS03825	COG1132	(ABC) transporter
L0B52_RS03830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L0B52_RS03835	COG0148	phosphopyruvate hydratase activity
L0B52_RS03840	COG0504	CTP synthase activity
L0B52_RS03845	COG0037	tRNA processing
L0B52_RS03855	COG0825	malonyl-CoA metabolic process
L0B52_RS03865	COG2198	Histidine kinase
L0B52_RS03865	COG0643	Histidine kinase
L0B52_RS03875	COG0840	transmembrane signaling receptor activity
L0B52_RS03880	COG0835	chemotaxis
L0B52_RS03895	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L0B52_RS03900	COG0492	ferredoxin-NADP+ reductase activity
L0B52_RS03905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L0B52_RS03915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L0B52_RS03920	COG0488	(ABC) transporter
L0B52_RS03925	COG1660	Displays ATPase and GTPase activities
L0B52_RS03930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L0B52_RS03935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L0B52_RS03950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L0B52_RS04015	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L0B52_RS04045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L0B52_RS04050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L0B52_RS04055	COG2089	acid synthase
L0B52_RS04075	COG1086	Polysaccharide biosynthesis protein
L0B52_RS04105	COG3034	peptidoglycan biosynthetic process
L0B52_RS04120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L0B52_RS04125	COG1561	YicC-like family, N-terminal region
L0B52_RS04130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L0B52_RS04135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L0B52_RS04140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L0B52_RS04160	COG0006	proline dipeptidase activity
L0B52_RS04255	COG3008	intermembrane lipid transfer
L0B52_RS04260	COG2995	paraquat-inducible protein a
L0B52_RS04265	COG2995	paraquat-inducible protein a
L0B52_RS04270	COG0670	Belongs to the BI1 family
L0B52_RS04275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L0B52_RS04280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L0B52_RS04285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L0B52_RS04310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L0B52_RS04315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L0B52_RS04320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L0B52_RS04320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L0B52_RS04330	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L0B52_RS04335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L0B52_RS04340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L0B52_RS04365	COG1028	Short-chain dehydrogenase reductase Sdr
L0B52_RS04370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L0B52_RS04375	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L0B52_RS04380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L0B52_RS04385	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L0B52_RS04390	COG0138	bifunctional purine biosynthesis protein purh
L0B52_RS04395	COG0471	metal ion transport
L0B52_RS04400	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L0B52_RS04405	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L0B52_RS04420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L0B52_RS04425	COG2321	neutral zinc metallopeptidase
L0B52_RS04430	COG2833	Protein of unknown function (DUF455)
L0B52_RS04465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L0B52_RS04470	COG0308	aminopeptidase N
L0B52_RS04475	COG0281	malic enzyme
L0B52_RS04475	COG0280	phosphate acetyltransferase
L0B52_RS04480	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L0B52_RS04490	COG0494	nUDIX hydrolase
L0B52_RS04500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L0B52_RS04510	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L0B52_RS04515	COG0527	aspartate kinase activity
L0B52_RS04520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L0B52_RS04525	COG2137	regulation of response to DNA damage stimulus
L0B52_RS04530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L0B52_RS04545	COG3425	synthase
L0B52_RS04590	COG0724	RNA recognition motif
L0B52_RS04600	COG1629	transport
L0B52_RS04600	COG4206	TonB-dependent receptor
L0B52_RS04605	COG2807	transmembrane transport
L0B52_RS04610	COG2095	MarC family integral membrane protein
L0B52_RS04615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L0B52_RS04620	COG2233	PERMEase
L0B52_RS04635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L0B52_RS04640	COG3038	cytochrome b561
L0B52_RS04645	COG0018	arginyl-trna synthetase
L0B52_RS04655	COG0730	response to heat
L0B52_RS04670	COG0275	rRNA processing
L0B52_RS04680	COG0488	(ABC) transporter
L0B52_RS04685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L0B52_RS04695	COG0204	Acyl-transferase
L0B52_RS04705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L0B52_RS04720	COG1216	Glycosyl transferase, family 2
L0B52_RS04775	COG1028	Short-chain dehydrogenase reductase Sdr
L0B52_RS04780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L0B52_RS04795	COG0360	Binds together with S18 to 16S ribosomal RNA
L0B52_RS04800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L0B52_RS04805	COG0359	binds to the 23S rRNA
L0B52_RS04810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L0B52_RS04815	COG0495	leucyl-tRNA aminoacylation
L0B52_RS04820	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L0B52_RS04825	COG3314	Sporulation integral membrane protein YlbJ
L0B52_RS04830	COG2986	histidine ammonia-lyase
L0B52_RS04835	COG0010	Belongs to the arginase family
L0B52_RS04840	COG1228	amidohydrolase
L0B52_RS04850	COG0561	phosphatase activity
L0B52_RS04855	COG0733	neurotransmitter:sodium symporter activity
L0B52_RS04870	COG0540	Belongs to the ATCase OTCase family
L0B52_RS04875	COG1490	D-aminoacyl-tRNA deacylase activity
L0B52_RS04915	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L0B52_RS04925	COG0459	protein refolding
L0B52_RS04930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L0B52_RS04940	COG0406	alpha-ribazole phosphatase activity
L0B52_RS04945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L0B52_RS04955	COG0237	dephospho-CoA kinase activity
L0B52_RS04985	COG0316	Belongs to the HesB IscA family
L0B52_RS04995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L0B52_RS05005	COG2814	Major facilitator Superfamily
L0B52_RS05010	COG0628	permease
L0B52_RS05015	COG2853	Lipoprotein
L0B52_RS05020	COG1162	GTPase activity
L0B52_RS05030	COG0142	geranyltranstransferase activity
L0B52_RS05040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L0B52_RS05090	COG2918	glutathione biosynthetic process
L0B52_RS05100	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L0B52_RS05105	COG2949	membrane
L0B52_RS05115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L0B52_RS05125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L0B52_RS05130	COG2003	Belongs to the UPF0758 family
L0B52_RS05150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L0B52_RS05160	COG1272	protein, Hemolysin III
L0B52_RS05165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L0B52_RS05170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L0B52_RS05175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L0B52_RS05180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L0B52_RS05185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L0B52_RS05190	COG0255	Belongs to the universal ribosomal protein uL29 family
L0B52_RS05195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L0B52_RS05200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L0B52_RS05205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L0B52_RS05210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L0B52_RS05215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L0B52_RS05220	COG0089	rRNA binding
L0B52_RS05225	COG0088	Forms part of the polypeptide exit tunnel
L0B52_RS05235	COG0051	transcription antitermination factor activity, RNA binding
L0B52_RS05240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L0B52_RS05245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L0B52_RS05250	COG0049	tRNA binding
L0B52_RS05255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L0B52_RS05260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L0B52_RS05265	COG0085	RNA polymerase activity
L0B52_RS05270	COG0222	ribosome binding
L0B52_RS05275	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L0B52_RS05280	COG0081	regulation of translation
L0B52_RS05285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L0B52_RS05305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L0B52_RS05330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L0B52_RS05335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L0B52_RS05340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L0B52_RS05345	COG1473	amidohydrolase
L0B52_RS05355	COG0006	proline dipeptidase activity
L0B52_RS05360	COG1012	belongs to the aldehyde dehydrogenase family
L0B52_RS05365	COG1538	Outer membrane efflux protein
L0B52_RS05370	COG0577	efflux transmembrane transporter activity
L0B52_RS05370	COG1136	(ABC) transporter
L0B52_RS05375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L0B52_RS05380	COG0826	peptidase U32
L0B52_RS05385	COG1393	Belongs to the ArsC family
L0B52_RS05420	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L0B52_RS05425	COG0372	Belongs to the citrate synthase family
L0B52_RS05430	COG2079	MmgE PrpD family protein
L0B52_RS05435	COG0788	formyltetrahydrofolate deformylase activity
L0B52_RS05440	COG0385	Bile acid
L0B52_RS05450	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
L0B52_RS05460	COG0271	Belongs to the BolA IbaG family
L0B52_RS05465	COG1160	GTP binding
L0B52_RS05470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L0B52_RS05475	COG2976	Protein conserved in bacteria
L0B52_RS05480	COG0124	histidyl-tRNA synthetase
L0B52_RS05495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L0B52_RS05500	COG0105	UTP biosynthetic process
L0B52_RS05510	COG1132	(ABC) transporter
L0B52_RS05560	COG0446	pyridine nucleotide-disulphide oxidoreductase
L0B52_RS05580	COG0204	Acyl-transferase
L0B52_RS05590	COG0751	glycine-tRNA ligase activity
L0B52_RS05595	COG0751	glycine-tRNA ligase activity
L0B52_RS05600	COG0752	glycyl-tRNA synthetase alpha subunit
L0B52_RS05620	COG0330	HflC and HflK could
L0B52_RS05625	COG1585	Membrane protein implicated in regulation of membrane protease activity
L0B52_RS05640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L0B52_RS05645	COG2915	High frequency lysogenization protein hflD homolog
L0B52_RS05650	COG0482	sulfurtransferase activity
L0B52_RS05655	COG1981	membrane
L0B52_RS05660	COG1840	ABC-type Fe3 transport system, periplasmic component
L0B52_RS05665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L0B52_RS05670	COG3842	ATPase activity
L0B52_RS05685	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
L0B52_RS05715	COG0686	Belongs to the AlaDH PNT family
L0B52_RS05725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L0B52_RS05745	COG0137	argininosuccinate synthase activity
L0B52_RS05760	COG0668	transmembrane transport
L0B52_RS05770	COG1704	LemA family
L0B52_RS05775	COG0658	competence protein
L0B52_RS05775	COG2333	competence protein COMEC
L0B52_RS05780	COG1653	transport
L0B52_RS05790	COG0395	ABC-type sugar transport system, permease component
L0B52_RS05795	COG3842	ATPase activity
L0B52_RS05805	COG2989	Protein conserved in bacteria
L0B52_RS05810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L0B52_RS05825	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L0B52_RS05835	COG2873	o-acetylhomoserine
L0B52_RS05850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L0B52_RS05860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L0B52_RS05880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L0B52_RS05885	COG0708	Exodeoxyribonuclease III
L0B52_RS05890	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L0B52_RS05895	COG0717	Belongs to the dCTP deaminase family
L0B52_RS05900	COG0489	protein tyrosine kinase activity
L0B52_RS05905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L0B52_RS05930	COG0471	metal ion transport
L0B52_RS05935	COG0471	metal ion transport
L0B52_RS05945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L0B52_RS05950	COG1185	polyribonucleotide nucleotidyltransferase activity
L0B52_RS05985	COG3189	MarR family transcriptional regulator
L0B52_RS05995	COG2239	Acts as a magnesium transporter
L0B52_RS06030	COG0668	transmembrane transport
L0B52_RS06060	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L0B52_RS06065	COG3135	benzoate transporter
L0B52_RS06075	COG1448	Aminotransferase
L0B52_RS06085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L0B52_RS06095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L0B52_RS06100	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L0B52_RS06110	COG2999	glutathione oxidoreductase activity
L0B52_RS06120	COG0583	DNA-binding transcription factor activity
L0B52_RS06125	COG0450	alkyl hydroperoxide reductase
L0B52_RS06140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L0B52_RS06145	COG0601	transmembrane transport
L0B52_RS06150	COG0747	negative chemotaxis
L0B52_RS06155	COG4172	Belongs to the ABC transporter superfamily
L0B52_RS06165	COG2056	Na+-H+ antiporter family
L0B52_RS06175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L0B52_RS06180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L0B52_RS06190	COG2814	Major facilitator Superfamily
L0B52_RS06205	COG2890	protein-(glutamine-N5) methyltransferase activity
L0B52_RS06210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L0B52_RS06215	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L0B52_RS06220	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L0B52_RS06240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L0B52_RS06245	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L0B52_RS06250	COG0193	aminoacyl-tRNA hydrolase activity
L0B52_RS06255	COG0012	GTP binding
L0B52_RS06260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L0B52_RS06285	COG0583	DNA-binding transcription factor activity
L0B52_RS06290	COG0814	amino acid
L0B52_RS06305	COG0814	amino acid
L0B52_RS06330	COG0277	FAD linked oxidase domain protein
L0B52_RS06355	COG1322	Protein conserved in bacteria
L0B52_RS06380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L0B52_RS06385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L0B52_RS06390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L0B52_RS06395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L0B52_RS06400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L0B52_RS06405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L0B52_RS06410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L0B52_RS06420	COG0356	it plays a direct role in the translocation of protons across the membrane
L0B52_RS06430	COG1475	DNA binding
L0B52_RS06435	COG1192	Involved in chromosome partitioning
L0B52_RS06445	COG0357	Ribosomal RNA small subunit methyltransferase G
L0B52_RS06450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L0B52_RS06465	COG3278	Belongs to the heme-copper respiratory oxidase family
L0B52_RS06475	COG2010	Cytochrome c
L0B52_RS06490	COG2217	Heavy metal translocating P-type atpase
L0B52_RS06505	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L0B52_RS06510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L0B52_RS06515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L0B52_RS06520	COG0857	belongs to the CobB CobQ family
L0B52_RS06520	COG0280	phosphate acetyltransferase
L0B52_RS06525	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L0B52_RS06530	COG0140	phosphoribosyl-ATP diphosphatase activity
L0B52_RS06540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L0B52_RS06565	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L0B52_RS06570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L0B52_RS06575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L0B52_RS06580	COG0215	cysteine-tRNA ligase activity
L0B52_RS06595	COG0742	ribosomal rna small subunit methyltransferase
L0B52_RS06605	COG1295	ribonuclease BN
L0B52_RS06625	COG0697	spore germination
L0B52_RS06630	COG1115	amino acid carrier protein
L0B52_RS06645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0B52_RS06650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L0B52_RS06655	COG1854	S-ribosylhomocysteine lyase activity
L0B52_RS06665	COG2081	HI0933 family
L0B52_RS06670	COG2824	Alkylphosphonate utilization operon protein PhnA
L0B52_RS06675	COG0179	Fumarylacetoacetate (FAA) hydrolase
L0B52_RS06685	COG2171	N-acyltransferase activity
L0B52_RS06690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L0B52_RS06690	COG2111	Na H antiporter
L0B52_RS06695	COG2111	Na H antiporter
L0B52_RS06700	COG1006	Multisubunit Na H antiporter MnhC subunit
L0B52_RS06705	COG0651	ATP synthesis coupled electron transport
L0B52_RS06710	COG1863	multisubunit Na H antiporter MnhE subunit
L0B52_RS06715	COG2212	antiporter activity
L0B52_RS06720	COG1320	monovalent cation:proton antiporter activity
L0B52_RS06750	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
L0B52_RS06770	COG0598	Magnesium transport protein CorA
L0B52_RS06775	COG2261	transglycosylase associated protein
L0B52_RS06780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L0B52_RS06800	COG1968	undecaprenyl-diphosphatase activity
L0B52_RS06815	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
L0B52_RS06820	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L0B52_RS06825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L0B52_RS06830	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
L0B52_RS06835	COG1012	belongs to the aldehyde dehydrogenase family
L0B52_RS06850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L0B52_RS06860	COG3716	PTS system mannose fructose sorbose family IID component
L0B52_RS06865	COG3715	PTS system
L0B52_RS06870	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L0B52_RS06875	COG2222	sugar isomerase
L0B52_RS06885	COG1349	DNA-binding transcription factor activity
L0B52_RS06965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L0B52_RS06975	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L0B52_RS06975	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L0B52_RS06975	COG0506	proline dehydrogenase activity
L0B52_RS06985	COG0469	pyruvate kinase activity
L0B52_RS06990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L0B52_RS06995	COG0583	DNA-binding transcription factor activity
L0B52_RS07005	COG3023	N-Acetylmuramoyl-L-alanine amidase
L0B52_RS07020	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L0B52_RS07025	COG0416	fatty acid biosynthetic process
L0B52_RS07030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L0B52_RS07035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L0B52_RS07045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L0B52_RS07055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L0B52_RS07060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L0B52_RS07065	COG0470	DNA polymerase III
L0B52_RS07075	COG0740	serine-type endopeptidase activity
L0B52_RS07080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L0B52_RS07085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L0B52_RS07100	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
L0B52_RS07125	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L0B52_RS07140	COG1929	Belongs to the glycerate kinase type-1 family
L0B52_RS07155	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L0B52_RS07160	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L0B52_RS07165	COG0739	heme binding
L0B52_RS07170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L0B52_RS07175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L0B52_RS07185	COG0783	Belongs to the Dps family
L0B52_RS07190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L0B52_RS07190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L0B52_RS07195	COG1611	Belongs to the LOG family
L0B52_RS07210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L0B52_RS07215	COG0149	triose-phosphate isomerase activity
L0B52_RS07220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L0B52_RS07235	COG1805	sodium ion transport
L0B52_RS07250	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L0B52_RS07260	COG1477	protein flavinylation
L0B52_RS07305	COG2431	L-lysine efflux transmembrane transporter activity
L0B52_RS07310	COG3264	Mechanosensitive ion channel
L0B52_RS07310	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
L0B52_RS07320	COG1673	EVE domain
L0B52_RS07345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L0B52_RS07350	COG1519	Transferase
L0B52_RS07355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L0B52_RS07360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L0B52_RS07365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L0B52_RS07375	COG0505	Belongs to the CarA family
L0B52_RS07380	COG1575	Belongs to the MenA family. Type 1 subfamily
L0B52_RS07385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L0B52_RS07400	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L0B52_RS07420	COG0339	signal peptide processing
L0B52_RS07440	COG0564	pseudouridine synthase activity
L0B52_RS07450	COG0045	succinate-CoA ligase (ADP-forming) activity
L0B52_RS07455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L0B52_RS07470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L0B52_RS07475	COG2204	response regulator
L0B52_RS07480	COG5000	phosphorelay sensor kinase activity
L0B52_RS07490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L0B52_RS07490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L0B52_RS07495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L0B52_RS07500	COG0242	peptide deformylase activity
L0B52_RS07505	COG1652	LysM domain
L0B52_RS07510	COG0758	DNA mediated transformation
L0B52_RS07515	COG2922	Belongs to the Smg family
L0B52_RS07540	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L0B52_RS07560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L0B52_RS07565	COG2264	protein methyltransferase activity
L0B52_RS07570	COG0439	Biotin carboxylase
L0B52_RS07575	COG0511	ligase activity, forming carbon-carbon bonds
L0B52_RS07580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L0B52_RS07590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L0B52_RS07595	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L0B52_RS07600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L0B52_RS07620	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L0B52_RS07625	COG1027	Aspartate ammonia-lyase
L0B52_RS07630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L0B52_RS07635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L0B52_RS07645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L0B52_RS07660	COG0604	alcohol dehydrogenase
L0B52_RS07675	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
L0B52_RS07680	COG0709	Synthesizes selenophosphate from selenide and ATP
L0B52_RS07685	COG2943	transferase activity, transferring hexosyl groups
L0B52_RS07690	COG2943	transferase activity, transferring hexosyl groups
L0B52_RS07695	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
L0B52_RS07700	COG0424	maF-like protein
L0B52_RS07705	COG1530	ribonuclease E activity
L0B52_RS07710	COG0625	glutathione transferase activity
L0B52_RS07740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L0B52_RS07780	COG3391	amine dehydrogenase activity
L0B52_RS07790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L0B52_RS07795	COG0346	lactoylglutathione lyase activity
L0B52_RS07800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L0B52_RS07805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L0B52_RS07810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L0B52_RS07815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L0B52_RS07820	COG1841	ribosomal large subunit assembly
L0B52_RS07825	COG0200	Binds to the 23S rRNA
L0B52_RS07835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L0B52_RS07840	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L0B52_RS07845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L0B52_RS07850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L0B52_RS07855	COG0202	RNA polymerase activity
L0B52_RS07860	COG0203	ribosomal protein L17
L0B52_RS07880	COG0569	domain protein
L0B52_RS07885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L0B52_RS07895	COG1012	belongs to the aldehyde dehydrogenase family
L0B52_RS07910	COG1012	belongs to the aldehyde dehydrogenase family
L0B52_RS07920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L0B52_RS07925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L0B52_RS07930	COG0583	DNA-binding transcription factor activity
L0B52_RS07945	COG0116	Belongs to the methyltransferase superfamily
L0B52_RS07945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L0B52_RS07955	COG0745	RESPONSE REGULATOR receiver
L0B52_RS07965	COG2205	protein histidine kinase activity
L0B52_RS07975	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
L0B52_RS07980	COG0156	8-amino-7-oxononanoate synthase activity
L0B52_RS07985	COG1063	alcohol dehydrogenase
L0B52_RS08010	COG0354	folic acid binding
L0B52_RS08015	COG5508	conserved small protein
L0B52_RS08025	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L0B52_RS08030	COG1053	succinate dehydrogenase
L0B52_RS08045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L0B52_RS08060	COG4658	electron transport chain
L0B52_RS08065	COG4656	Part of a membrane complex involved in electron transport
L0B52_RS08070	COG2878	Part of a membrane complex involved in electron transport
L0B52_RS08075	COG4657	Part of a membrane complex involved in electron transport
L0B52_RS08090	COG0154	amidase activity
L0B52_RS08095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L0B52_RS08100	COG1077	Cell shape determining protein MreB Mrl
L0B52_RS08105	COG1792	Involved in formation and maintenance of cell shape
L0B52_RS08115	COG0768	penicillin binding
L0B52_RS08120	COG0772	Belongs to the SEDS family
L0B52_RS08125	COG2951	lytic endotransglycosylase activity
L0B52_RS08140	COG2921	Belongs to the UPF0250 family
L0B52_RS08145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L0B52_RS08180	COG0305	Participates in initiation and elongation during chromosome replication
L0B52_RS08185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L0B52_RS08195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L0B52_RS08210	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
L0B52_RS08215	COG1530	ribonuclease E activity
L0B52_RS08225	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L0B52_RS08230	COG0322	excinuclease ABC activity
L0B52_RS08245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L0B52_RS08255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L0B52_RS08260	COG1758	RNA polymerase activity
L0B52_RS08270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L0B52_RS08275	COG0259	pyridoxamine-phosphate oxidase activity
L0B52_RS08280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L0B52_RS08285	COG0268	Binds directly to 16S ribosomal RNA
L0B52_RS08295	COG0579	oxidoreductase
L0B52_RS08310	COG0471	metal ion transport
L0B52_RS08320	COG1760	l-serine dehydratase
L0B52_RS08325	COG3977	Valine--pyruvate aminotransferase
L0B52_RS08340	COG1643	Atp-dependent helicase
L0B52_RS08350	COG1960	acyl-CoA dehydrogenase activity
L0B52_RS08355	COG1024	Enoyl-CoA hydratase
L0B52_RS08355	COG1250	3-hydroxyacyl-CoA dehydrogenase
L0B52_RS08360	COG0183	Belongs to the thiolase family
L0B52_RS08365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L0B52_RS08370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L0B52_RS08375	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L0B52_RS08395	COG1652	LysM domain
L0B52_RS08405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L0B52_RS08415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L0B52_RS08420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L0B52_RS08425	COG2855	membrane
L0B52_RS08440	COG0842	Transport permease protein
L0B52_RS08445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L0B52_RS08455	COG4536	flavin adenine dinucleotide binding
L0B52_RS08465	COG2995	paraquat-inducible protein a
L0B52_RS08475	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
L0B52_RS08480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L0B52_RS08495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L0B52_RS08500	COG1136	(ABC) transporter
L0B52_RS08510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L0B52_RS08515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L0B52_RS08530	COG0813	purine-nucleoside phosphorylase activity
L0B52_RS08535	COG0133	tryptophan synthase activity
L0B52_RS08540	COG0410	ABC transporter
L0B52_RS08570	COG1136	(ABC) transporter
L0B52_RS08580	COG1785	Belongs to the alkaline phosphatase family
L0B52_RS08585	COG0588	phosphoglycerate mutase activity
L0B52_RS08610	COG0544	peptidyl-prolyl cis-trans isomerase activity
L0B52_RS08625	COG0084	hydrolase, TatD family'
L0B52_RS08630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L0B52_RS08640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L0B52_RS08645	COG0134	indole-3-glycerol-phosphate synthase activity
L0B52_RS08650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L0B52_RS08670	COG1509	lysine 2,3-aminomutase activity
L0B52_RS08685	COG0789	Transcriptional regulator
L0B52_RS08690	COG2217	Heavy metal translocating P-type atpase
L0B52_RS08690	COG2608	mercury ion transmembrane transporter activity
L0B52_RS08695	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
L0B52_RS08705	COG0295	cytidine deaminase activity
L0B52_RS08710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L0B52_RS08715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L0B52_RS08720	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L0B52_RS08725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L0B52_RS08725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L0B52_RS08730	COG1047	Peptidyl-prolyl cis-trans
L0B52_RS08735	COG0736	holo-[acyl-carrier-protein] synthase activity
L0B52_RS08745	COG1178	ABC-type Fe3 transport system permease component
L0B52_RS08755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L0B52_RS08760	COG1966	Carbon starvation protein
L0B52_RS08770	COG0003	Pfam Anion-transporting ATPase
L0B52_RS08790	COG0823	Involved in the tonB-independent uptake of proteins
L0B52_RS08810	COG0028	Belongs to the TPP enzyme family
L0B52_RS08825	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
L0B52_RS08830	COG4120	Belongs to the binding-protein-dependent transport system permease family
L0B52_RS08840	COG1115	amino acid carrier protein
L0B52_RS08855	COG3448	diguanylate cyclase activity
L0B52_RS08855	COG4175	Glycine betaine
L0B52_RS08875	COG0463	Glycosyl transferase, family 2
L0B52_RS08885	COG3394	polysaccharide catabolic process
L0B52_RS08895	COG1131	(ABC) transporter
L0B52_RS08900	COG0842	Transport permease protein
L0B52_RS08905	COG3030	protein affecting phage T7 exclusion by the F plasmid
L0B52_RS08925	COG2205	protein histidine kinase activity
L0B52_RS08930	COG0745	RESPONSE REGULATOR receiver
L0B52_RS08935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L0B52_RS08940	COG2823	Periplasmic or secreted lipoprotein
L0B52_RS08950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L0B52_RS08965	COG2204	response regulator
L0B52_RS08970	COG3852	Histidine kinase
L0B52_RS08975	COG0174	glutamine synthetase
L0B52_RS08985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L0B52_RS09010	COG0436	Aminotransferase
L0B52_RS09045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L0B52_RS09050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L0B52_RS09060	COG3001	Fructosamine kinase
L0B52_RS09080	COG2249	NAD(P)H dehydrogenase (quinone) activity
L0B52_RS09085	COG2917	probably involved in intracellular septation
L0B52_RS09095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L0B52_RS09100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L0B52_RS09105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L0B52_RS09130	COG1217	gtp-binding protein TYPA
L0B52_RS09135	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L0B52_RS09140	COG0072	phenylalanine-tRNA ligase activity
L0B52_RS09140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L0B52_RS09145	COG0776	regulation of translation
L0B52_RS09150	COG0217	transcriptional regulatory protein
L0B52_RS09155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L0B52_RS09160	COG0632	four-way junction helicase activity
L0B52_RS09165	COG2255	four-way junction helicase activity
L0B52_RS09170	COG0039	L-malate dehydrogenase activity
L0B52_RS09180	COG0442	prolyl-tRNA aminoacylation
L0B52_RS09185	COG1024	Enoyl-CoA hydratase
L0B52_RS09185	COG1250	3-hydroxyacyl-CoA dehydrogenase
L0B52_RS09190	COG1024	Enoyl-CoA hydratase
L0B52_RS09190	COG1250	3-hydroxyacyl-CoA dehydrogenase
L0B52_RS09195	COG0585	pseudouridine synthase activity
L0B52_RS09210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L0B52_RS09230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L0B52_RS09235	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
L0B52_RS09245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L0B52_RS09255	COG1737	Transcriptional regulator
L0B52_RS09280	COG1917	Cupin 2, conserved barrel domain protein
L0B52_RS09285	COG1917	Cupin 2, conserved barrel domain protein
L0B52_RS09290	COG0527	aspartate kinase activity
L0B52_RS09310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L0B52_RS09315	COG0415	Belongs to the DNA photolyase family
L0B52_RS09320	COG0513	Belongs to the DEAD box helicase family
L0B52_RS09330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L0B52_RS09335	COG0728	peptidoglycan biosynthetic process
L0B52_RS09340	COG0729	surface antigen
L0B52_RS09355	COG0501	Belongs to the peptidase M48B family
L0B52_RS09365	COG2239	Acts as a magnesium transporter
L0B52_RS09375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L0B52_RS09385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L0B52_RS09395	COG0484	heat shock protein binding
L0B52_RS09400	COG0443	Heat shock 70 kDa protein
L0B52_RS09405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L0B52_RS09410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L0B52_RS09425	COG0166	Belongs to the GPI family
L0B52_RS09430	COG0033	Phosphoglucomutase
L0B52_RS09445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L0B52_RS09455	COG0135	phosphoribosylanthranilate isomerase activity
L0B52_RS09475	COG1999	signal sequence binding
L0B52_RS09485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L0B52_RS09485	COG3153	acetyltransferase
L0B52_RS09495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L0B52_RS09520	COG3577	Aspartyl protease
L0B52_RS09535	COG0142	geranyltranstransferase activity
L0B52_RS09545	COG1127	ABC transporter
L0B52_RS09550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L0B52_RS09555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L0B52_RS09570	COG0271	Belongs to the BolA IbaG family
L0B52_RS09575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L0B52_RS09580	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L0B52_RS09590	COG0719	Fe-S assembly protein
L0B52_RS09600	COG0009	L-threonylcarbamoyladenylate synthase
L0B52_RS09615	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
L0B52_RS09625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes