locus-tag	class	description
E3D00_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E3D00_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E3D00_RS00030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3D00_RS00035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3D00_RS00040	COG0247	lactate metabolic process
E3D00_RS00040	COG0277	FAD linked oxidase domain protein
E3D00_RS00060	COG2022	thiamine diphosphate biosynthetic process
E3D00_RS00075	COG3104	oligopeptide transport
E3D00_RS00080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3D00_RS00080	COG0321	lipoyl(octanoyl) transferase activity
E3D00_RS00085	COG0084	hydrolase, TatD family'
E3D00_RS00090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3D00_RS00100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3D00_RS00105	COG1686	Belongs to the peptidase S11 family
E3D00_RS00115	COG2951	lytic endotransglycosylase activity
E3D00_RS00135	COG1968	undecaprenyl-diphosphatase activity
E3D00_RS00140	COG0531	amino acid
E3D00_RS00165	COG2890	protein-(glutamine-N5) methyltransferase activity
E3D00_RS00175	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E3D00_RS00180	COG0124	histidyl-tRNA synthetase
E3D00_RS00185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E3D00_RS00195	COG2070	2-Nitropropane dioxygenase
E3D00_RS00200	COG0527	aspartate kinase activity
E3D00_RS00205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3D00_RS00215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3D00_RS00240	COG0321	lipoyl(octanoyl) transferase activity
E3D00_RS00250	COG0271	Belongs to the BolA IbaG family
E3D00_RS00280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3D00_RS00285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3D00_RS00300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E3D00_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3D00_RS00310	COG0077	Prephenate dehydratase
E3D00_RS00315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E3D00_RS00325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3D00_RS00330	COG0606	chelatase, subunit chli
E3D00_RS00335	COG0626	cystathionine gamma-synthase activity
E3D00_RS00340	COG2897	thiosulfate sulfurtransferase activity
E3D00_RS00345	COG0628	permease
E3D00_RS00355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3D00_RS00360	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E3D00_RS00365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3D00_RS00375	COG1381	Involved in DNA repair and RecF pathway recombination
E3D00_RS00380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E3D00_RS00385	COG0052	Belongs to the universal ribosomal protein uS2 family
E3D00_RS00395	COG1136	(ABC) transporter
E3D00_RS00405	COG0442	prolyl-tRNA aminoacylation
E3D00_RS00415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E3D00_RS00430	COG0776	regulation of translation
E3D00_RS00440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E3D00_RS00445	COG0740	serine-type endopeptidase activity
E3D00_RS00450	COG0544	peptidyl-prolyl cis-trans isomerase activity
E3D00_RS00470	COG0513	Belongs to the DEAD box helicase family
E3D00_RS00475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3D00_RS00480	COG0316	Belongs to the HesB IscA family
E3D00_RS00485	COG2151	metal-sulfur cluster biosynthetic enzyme
E3D00_RS00490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3D00_RS00495	COG0719	Fe-S assembly protein
E3D00_RS00500	COG0396	ATPase activity
E3D00_RS00505	COG0719	Fe-S assembly protein
E3D00_RS00515	COG2733	membrane
E3D00_RS00530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E3D00_RS00535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E3D00_RS00540	COG5265	(ABC) transporter
E3D00_RS00550	COG0628	permease
E3D00_RS00565	COG0776	regulation of translation
E3D00_RS00570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3D00_RS00575	COG0416	fatty acid biosynthetic process
E3D00_RS00580	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E3D00_RS00600	COG0745	RESPONSE REGULATOR receiver
E3D00_RS00610	COG0242	peptide deformylase activity
E3D00_RS00615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E3D00_RS00620	COG1505	serine-type exopeptidase activity
E3D00_RS00625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3D00_RS00630	COG1360	Flagellar Motor Protein
E3D00_RS00645	COG1522	sequence-specific DNA binding
E3D00_RS00650	COG0492	ferredoxin-NADP+ reductase activity
E3D00_RS00660	COG0776	regulation of translation
E3D00_RS00665	COG0616	signal peptide processing
E3D00_RS00670	COG4957	zinc ion binding
E3D00_RS00675	COG1289	transmembrane transporter activity
E3D00_RS00680	COG1028	Short-chain dehydrogenase reductase Sdr
E3D00_RS00720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E3D00_RS00725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E3D00_RS00730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E3D00_RS00735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3D00_RS00745	COG3750	Belongs to the UPF0335 family
E3D00_RS00750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3D00_RS00760	COG0657	acetylesterase activity
E3D00_RS00770	COG2001	Belongs to the MraZ family
E3D00_RS00775	COG0275	rRNA processing
E3D00_RS00790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3D00_RS00800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3D00_RS00805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3D00_RS00815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E3D00_RS00820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3D00_RS00825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3D00_RS00830	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3D00_RS00840	COG0849	cell division
E3D00_RS00850	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E3D00_RS00855	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3D00_RS00860	COG0497	DNA recombination
E3D00_RS00865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3D00_RS00870	COG1253	flavin adenine dinucleotide binding
E3D00_RS00875	COG1335	isochorismatase
E3D00_RS00890	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E3D00_RS00905	COG0328	RNA-DNA hybrid ribonuclease activity
E3D00_RS00910	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3D00_RS00915	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E3D00_RS00925	COG1297	OPT oligopeptide transporter protein
E3D00_RS00960	COG0436	Aminotransferase
E3D00_RS00965	COG0436	Aminotransferase
E3D00_RS00970	COG0473	3-isopropylmalate dehydrogenase activity
E3D00_RS00975	COG0066	3-isopropylmalate dehydratase activity
E3D00_RS00980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E3D00_RS00985	COG0335	large ribosomal subunit rRNA binding
E3D00_RS00990	COG0336	Belongs to the RNA methyltransferase TrmD family
E3D00_RS00995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E3D00_RS01000	COG0228	four-way junction DNA binding
E3D00_RS01005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3D00_RS01020	COG5434	Belongs to the glycosyl hydrolase 28 family
E3D00_RS01035	COG0515	serine threonine protein kinase
E3D00_RS01140	COG0513	Belongs to the DEAD box helicase family
E3D00_RS01145	COG2813	Specifically methylates the guanine in position
E3D00_RS01145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3D00_RS01150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3D00_RS01205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3D00_RS01210	COG0655	NAD(P)H dehydrogenase (quinone) activity
E3D00_RS01275	COG1692	metallophosphoesterase
E3D00_RS01280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3D00_RS01320	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E3D00_RS01330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E3D00_RS01335	COG0483	inositol monophosphate 1-phosphatase activity
E3D00_RS01355	COG0481	GTPase activity
E3D00_RS01375	COG2252	PERMEase
E3D00_RS01385	COG0425	Belongs to the sulfur carrier protein TusA family
E3D00_RS01390	COG1722	exodeoxyribonuclease VII activity
E3D00_RS01395	COG0142	geranyltranstransferase activity
E3D00_RS01400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E3D00_RS01405	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E3D00_RS01415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E3D00_RS01420	COG0137	argininosuccinate synthase activity
E3D00_RS01425	COG0545	Peptidyl-prolyl cis-trans isomerase
E3D00_RS01430	COG1435	thymidine kinase activity
E3D00_RS01440	COG0180	Tryptophanyl-tRNA synthetase
E3D00_RS01445	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3D00_RS01450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3D00_RS01450	COG0072	phenylalanine-tRNA ligase activity
E3D00_RS01455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E3D00_RS01460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E3D00_RS01465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E3D00_RS01470	COG4993	Dehydrogenase
E3D00_RS01475	COG2942	2-epimerase
E3D00_RS01480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3D00_RS01480	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E3D00_RS01495	COG2166	iron-sulfur cluster assembly
E3D00_RS01500	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E3D00_RS01505	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E3D00_RS01530	COG2884	Cell division ATP-binding protein ftsE
E3D00_RS01555	COG1271	oxidase subunit
E3D00_RS01560	COG1294	oxidase, subunit
E3D00_RS01570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3D00_RS01580	COG0688	phosphatidylethanolamine metabolic process
E3D00_RS01585	COG1183	phosphatidylcholine synthase activity
E3D00_RS01590	COG1940	carbohydrate kinase activity
E3D00_RS01595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3D00_RS01625	COG0656	L-ascorbic acid biosynthetic process
E3D00_RS01635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3D00_RS01640	COG1218	3'(2'),5'-bisphosphate nucleotidase
E3D00_RS01645	COG0009	L-threonylcarbamoyladenylate synthase
E3D00_RS01665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3D00_RS01670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3D00_RS01675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3D00_RS01680	COG0519	Catalyzes the synthesis of GMP from XMP
E3D00_RS01685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3D00_RS01690	COG0359	binds to the 23S rRNA
E3D00_RS01695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3D00_RS01700	COG0360	Binds together with S18 to 16S ribosomal RNA
E3D00_RS01705	COG0456	acetyltransferase
E3D00_RS01710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3D00_RS01730	COG0505	Belongs to the CarA family
E3D00_RS01735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3D00_RS01740	COG3655	Transcriptional regulator
E3D00_RS01745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3D00_RS01750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3D00_RS01760	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E3D00_RS01765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3D00_RS01775	COG0793	Belongs to the peptidase S41A family
E3D00_RS01785	COG0494	nUDIX hydrolase
E3D00_RS01790	COG1132	(ABC) transporter
E3D00_RS01795	COG0617	tRNA 3'-terminal CCA addition
E3D00_RS01805	COG0714	Associated with various cellular activities
E3D00_RS01830	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E3D00_RS01850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3D00_RS01855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3D00_RS01875	COG2814	Major facilitator Superfamily
E3D00_RS01880	COG0203	ribosomal protein L17
E3D00_RS01885	COG0202	RNA polymerase activity
E3D00_RS01890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E3D00_RS01895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E3D00_RS01900	COG0563	adenylate kinase activity
E3D00_RS01910	COG0200	Binds to the 23S rRNA
E3D00_RS01915	COG1841	ribosomal large subunit assembly
E3D00_RS01920	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E3D00_RS01925	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E3D00_RS01930	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E3D00_RS01935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E3D00_RS01940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E3D00_RS01945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E3D00_RS01950	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E3D00_RS01955	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E3D00_RS01960	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E3D00_RS01965	COG0255	Belongs to the universal ribosomal protein uL29 family
E3D00_RS01970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E3D00_RS01975	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E3D00_RS01980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E3D00_RS01985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3D00_RS01990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E3D00_RS01995	COG0089	rRNA binding
E3D00_RS02000	COG0088	Forms part of the polypeptide exit tunnel
E3D00_RS02005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E3D00_RS02010	COG0051	transcription antitermination factor activity, RNA binding
E3D00_RS02015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3D00_RS02020	COG0049	tRNA binding
E3D00_RS02025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E3D00_RS02030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E3D00_RS02035	COG0085	RNA polymerase activity
E3D00_RS02040	COG0222	ribosome binding
E3D00_RS02045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E3D00_RS02050	COG0081	regulation of translation
E3D00_RS02055	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E3D00_RS02075	COG2205	protein histidine kinase activity
E3D00_RS02080	COG0745	RESPONSE REGULATOR receiver
E3D00_RS02085	COG1322	Protein conserved in bacteria
E3D00_RS02095	COG2081	HI0933 family
E3D00_RS02105	COG0850	regulation of cytokinetic process
E3D00_RS02115	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E3D00_RS02140	COG0495	leucyl-tRNA aminoacylation
E3D00_RS02200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3D00_RS02205	COG0154	amidase activity
E3D00_RS02210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3D00_RS02215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E3D00_RS02225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3D00_RS02235	COG0038	chloride channel
E3D00_RS02245	COG2010	Cytochrome c
E3D00_RS02245	COG4993	Dehydrogenase
E3D00_RS02250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3D00_RS02255	COG0431	NADPH-dependent FMN reductase
E3D00_RS02260	COG0625	glutathione transferase activity
E3D00_RS02265	COG0126	phosphoglycerate kinase activity
E3D00_RS02290	COG1113	amino acid transport
E3D00_RS02300	COG1393	Belongs to the ArsC family
E3D00_RS02305	COG2814	Major facilitator Superfamily
E3D00_RS02315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3D00_RS02320	COG3158	transport of potassium into the cell
E3D00_RS02325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3D00_RS02345	COG1185	polyribonucleotide nucleotidyltransferase activity
E3D00_RS02350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E3D00_RS02355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E3D00_RS02360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E3D00_RS02365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E3D00_RS02380	COG0779	Required for maturation of 30S ribosomal subunits
E3D00_RS02390	COG0542	response to heat
E3D00_RS02400	COG0765	amino acid transport
E3D00_RS02410	COG4133	protoheme IX ABC transporter activity
E3D00_RS02415	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3D00_RS02420	COG1238	metal cluster binding
E3D00_RS02425	COG0741	lytic transglycosylase activity
E3D00_RS02440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E3D00_RS02455	COG1304	FMN binding
E3D00_RS02460	COG0302	gtp cyclohydrolase
E3D00_RS02470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E3D00_RS02475	COG0602	queuosine metabolic process
E3D00_RS02490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3D00_RS02495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3D00_RS02505	COG0405	Gamma-glutamyltransferase
E3D00_RS02510	COG1338	Plays a role in the flagellum-specific transport system
E3D00_RS02520	COG1815	bacterial-type flagellum-dependent cell motility
E3D00_RS02525	COG1558	bacterial-type flagellum-dependent cell motility
E3D00_RS02530	COG1677	Flagellar hook-basal body complex protein FliE
E3D00_RS02535	COG1987	bacterial-type flagellum assembly
E3D00_RS02550	COG4206	TonB-dependent receptor
E3D00_RS02555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E3D00_RS02565	COG0740	serine-type endopeptidase activity
E3D00_RS02575	COG0436	Aminotransferase
E3D00_RS02585	COG1494	fructose-1,6-bisphosphatase
E3D00_RS02590	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E3D00_RS02590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3D00_RS02630	COG0679	Auxin Efflux Carrier
E3D00_RS02640	COG0667	Aldo Keto reductase
E3D00_RS02645	COG0438	transferase activity, transferring glycosyl groups
E3D00_RS02650	COG1278	Cold shock
E3D00_RS02655	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E3D00_RS02690	COG3794	PFAM blue (type 1) copper domain protein
E3D00_RS02695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E3D00_RS02715	COG4774	siderophore transport
E3D00_RS02720	COG3128	pkhd-type hydroxylase
E3D00_RS02740	COG1609	Transcriptional regulator
E3D00_RS02750	COG3525	Glycosyl hydrolase, family 20, catalytic domain
E3D00_RS02755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3D00_RS02760	COG1120	ATPase activity
E3D00_RS02765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3D00_RS02770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3D00_RS02770	COG2010	Cytochrome c
E3D00_RS02800	COG0612	Peptidase, M16
E3D00_RS02820	COG0539	negative regulation of cytoplasmic translation
E3D00_RS02825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E3D00_RS02830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E3D00_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
E3D00_RS02850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3D00_RS02855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E3D00_RS02860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3D00_RS02875	COG0024	Methionine aminopeptidase
E3D00_RS02885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E3D00_RS02900	COG1942	4-Oxalocrotonate Tautomerase
E3D00_RS02905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3D00_RS02910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3D00_RS02935	COG2814	Major facilitator Superfamily
E3D00_RS02950	COG1706	bacterial-type flagellum-dependent cell motility
E3D00_RS02965	COG1253	flavin adenine dinucleotide binding
E3D00_RS02985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3D00_RS02990	COG3394	polysaccharide catabolic process
E3D00_RS02995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3D00_RS03025	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E3D00_RS03035	COG1074	ATP-dependent DNA helicase activity
E3D00_RS03045	COG0802	atpase or kinase
E3D00_RS03060	COG0492	ferredoxin-NADP+ reductase activity
E3D00_RS03065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3D00_RS03070	COG1063	alcohol dehydrogenase
E3D00_RS03085	COG1217	gtp-binding protein TYPA
E3D00_RS03090	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E3D00_RS03095	COG2746	aminoglycoside 3-N-acetyltransferase activity
E3D00_RS03150	COG0668	transmembrane transport
E3D00_RS03160	COG4774	siderophore transport
E3D00_RS03175	COG0473	3-isopropylmalate dehydrogenase activity
E3D00_RS03180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3D00_RS03195	COG4608	Belongs to the ABC transporter superfamily
E3D00_RS03200	COG0444	Belongs to the ABC transporter superfamily
E3D00_RS03210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3D00_RS03220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3D00_RS03225	COG2217	Heavy metal translocating P-type atpase
E3D00_RS03230	COG2132	Multicopper oxidase
E3D00_RS03290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E3D00_RS03295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E3D00_RS03300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E3D00_RS03305	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E3D00_RS03310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3D00_RS03325	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3D00_RS03340	COG3008	intermembrane lipid transfer
E3D00_RS03345	COG2995	paraquat-inducible protein a
E3D00_RS03365	COG1064	alcohol dehydrogenase
E3D00_RS03375	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E3D00_RS03415	COG1420	regulation of RNA biosynthetic process
E3D00_RS03420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3D00_RS03425	COG0668	transmembrane transport
E3D00_RS03460	COG5265	(ABC) transporter
E3D00_RS03465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3D00_RS03470	COG1472	Belongs to the glycosyl hydrolase 3 family
E3D00_RS03480	COG2333	competence protein COMEC
E3D00_RS03480	COG0658	competence protein
E3D00_RS03495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3D00_RS03500	COG0540	Belongs to the ATCase OTCase family
E3D00_RS03505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E3D00_RS03510	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E3D00_RS03515	COG0758	DNA mediated transformation
E3D00_RS03520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3D00_RS03525	COG0793	Belongs to the peptidase S41A family
E3D00_RS03535	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3D00_RS03535	COG2885	chlorophyll binding
E3D00_RS03550	COG0187	DNA topoisomerase II activity
E3D00_RS03560	COG1113	amino acid transport
E3D00_RS03565	COG2175	clavaminate synthase activity
E3D00_RS03585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3D00_RS03590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E3D00_RS03600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3D00_RS03605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E3D00_RS03620	COG0196	riboflavin kinase activity
E3D00_RS03625	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
E3D00_RS03630	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E3D00_RS03635	COG0235	Class ii aldolase
E3D00_RS03640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3D00_RS03645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3D00_RS03685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3D00_RS03690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3D00_RS03695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3D00_RS03850	COG0305	Participates in initiation and elongation during chromosome replication
E3D00_RS03855	COG0285	dihydrofolate synthase activity
E3D00_RS03860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E3D00_RS03870	COG0159	tryptophan synthase activity
E3D00_RS03875	COG0133	tryptophan synthase activity
E3D00_RS03880	COG0598	Magnesium transport protein CorA
E3D00_RS03890	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3D00_RS03900	COG1959	2 iron, 2 sulfur cluster binding
E3D00_RS03905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3D00_RS03925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3D00_RS03935	COG0477	Major facilitator Superfamily
E3D00_RS03945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3D00_RS03950	COG1064	alcohol dehydrogenase
E3D00_RS03955	COG1054	Belongs to the UPF0176 family
E3D00_RS03995	COG2814	Major facilitator Superfamily
E3D00_RS04000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E3D00_RS04010	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E3D00_RS04030	COG0175	sulfate reduction
E3D00_RS04040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3D00_RS04045	COG1127	ABC transporter
E3D00_RS04115	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E3D00_RS04120	COG4786	Flagellar basal body rod
E3D00_RS04125	COG4786	Flagellar basal body rod
E3D00_RS04135	COG1464	Belongs to the NlpA lipoprotein family
E3D00_RS04140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3D00_RS04145	COG2011	ABC-type metal ion transport system permease component
E3D00_RS04155	COG2267	carboxylic ester hydrolase activity
E3D00_RS04175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3D00_RS04185	COG0463	Glycosyl transferase, family 2
E3D00_RS04195	COG1538	Outer membrane efflux protein
E3D00_RS04205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3D00_RS04210	COG3047	cAMP biosynthetic process
E3D00_RS04215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3D00_RS04230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3D00_RS04230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3D00_RS04235	COG0307	riboflavin synthase, alpha
E3D00_RS04240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3D00_RS04240	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3D00_RS04245	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E3D00_RS04250	COG0535	radical SAM domain protein
E3D00_RS04260	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
E3D00_RS04265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3D00_RS04275	COG0194	GDP metabolic process
E3D00_RS04280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E3D00_RS04285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3D00_RS04290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E3D00_RS04295	COG0424	maF-like protein
E3D00_RS04315	COG0667	Aldo Keto reductase
E3D00_RS04350	COG0534	Mate efflux family protein
E3D00_RS04355	COG1749	Flagellar hook protein flgE
E3D00_RS04370	COG0326	Molecular chaperone. Has ATPase activity
E3D00_RS04380	COG1621	beta-fructofuranosidase activity
E3D00_RS04395	COG0586	Pfam SNARE associated Golgi protein
E3D00_RS04400	COG1028	Short-chain dehydrogenase reductase Sdr
E3D00_RS04405	COG1981	membrane
E3D00_RS04410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3D00_RS04415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E3D00_RS04420	COG0424	maF-like protein
E3D00_RS04430	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3D00_RS04455	COG0463	Glycosyl transferase, family 2
E3D00_RS04455	COG1216	Glycosyl transferase, family 2
E3D00_RS04460	COG1091	dTDP-4-dehydrorhamnose reductase activity
E3D00_RS04500	COG0357	Ribosomal RNA small subunit methyltransferase G
E3D00_RS04505	COG0445	tRNA wobble uridine modification
E3D00_RS04510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E3D00_RS04515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3D00_RS04520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3D00_RS04565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E3D00_RS04575	COG3961	Belongs to the TPP enzyme family
E3D00_RS04585	COG1194	a g-specific adenine glycosylase
E3D00_RS04600	COG0560	Phosphoserine phosphatase
E3D00_RS04605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E3D00_RS04610	COG0028	Belongs to the TPP enzyme family
E3D00_RS04620	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E3D00_RS04625	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E3D00_RS04630	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E3D00_RS04640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3D00_RS04645	COG0509	glycine decarboxylation via glycine cleavage system
E3D00_RS04650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3D00_RS04650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3D00_RS04695	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E3D00_RS04700	COG0463	Glycosyl transferase, family 2
E3D00_RS04705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E3D00_RS04710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E3D00_RS04715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3D00_RS04720	COG0356	it plays a direct role in the translocation of protons across the membrane
E3D00_RS04730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3D00_RS04750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E3D00_RS04755	COG5487	UPF0391 membrane protein
E3D00_RS04765	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3D00_RS04765	COG0463	Glycosyl transferase, family 2
E3D00_RS04780	COG3754	Rhamnan synthesis protein F
E3D00_RS04805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3D00_RS04810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E3D00_RS04815	COG1496	oxidoreductase activity
E3D00_RS04820	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E3D00_RS04825	COG0193	aminoacyl-tRNA hydrolase activity
E3D00_RS04835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E3D00_RS04840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E3D00_RS04845	COG0799	negative regulation of ribosome biogenesis
E3D00_RS04850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E3D00_RS04865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3D00_RS04920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E3D00_RS04930	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
E3D00_RS04935	COG0732	type I restriction modification DNA specificity domain
E3D00_RS04940	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3D00_RS04955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3D00_RS04970	COG2373	Large extracellular alpha-helical protein
E3D00_RS04975	COG4953	penicillin-binding protein 1C
E3D00_RS04995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E3D00_RS05000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3D00_RS05015	COG3038	cytochrome b561
E3D00_RS05020	COG2353	YceI-like domain
E3D00_RS05025	COG0583	DNA-binding transcription factor activity
E3D00_RS05030	COG1741	Belongs to the pirin family
E3D00_RS05050	COG1596	polysaccharide export
E3D00_RS05085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3D00_RS05095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E3D00_RS05120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E3D00_RS05125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E3D00_RS05130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E3D00_RS05135	COG0484	heat shock protein binding
E3D00_RS05140	COG0443	Heat shock 70 kDa protein
E3D00_RS05175	COG0717	Belongs to the dCTP deaminase family
E3D00_RS05180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3D00_RS05200	COG0277	FAD linked oxidase domain protein
E3D00_RS05205	COG1999	signal sequence binding
E3D00_RS05210	COG1956	GAF domain-containing protein
E3D00_RS05225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3D00_RS05245	COG2814	Major facilitator Superfamily
E3D00_RS05255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3D00_RS05260	COG0778	Nitroreductase
E3D00_RS05265	COG1643	Atp-dependent helicase
E3D00_RS05270	COG2259	Doxx family
E3D00_RS05280	COG0745	RESPONSE REGULATOR receiver
E3D00_RS05285	COG2205	protein histidine kinase activity
E3D00_RS05305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E3D00_RS05310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E3D00_RS05325	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3D00_RS05330	COG0745	RESPONSE REGULATOR receiver
E3D00_RS05335	COG0642	Histidine kinase
E3D00_RS05340	COG1660	Displays ATPase and GTPase activities
E3D00_RS05345	COG0735	belongs to the Fur family
E3D00_RS05355	COG2814	Major facilitator Superfamily
E3D00_RS05360	COG0564	pseudouridine synthase activity
E3D00_RS05365	COG1674	ftsk spoiiie
E3D00_RS05370	COG0742	ribosomal rna small subunit methyltransferase
E3D00_RS05375	COG1187	pseudouridine synthase activity
E3D00_RS05380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3D00_RS05385	COG0590	tRNA wobble adenosine to inosine editing
E3D00_RS05405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E3D00_RS05420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3D00_RS05430	COG2814	Major facilitator Superfamily
E3D00_RS05460	COG0778	Nitroreductase
E3D00_RS05495	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3D00_RS05500	COG1396	sequence-specific DNA binding
E3D00_RS05515	COG2835	tetraacyldisaccharide 4'-kinase activity
E3D00_RS05520	COG3118	belongs to the thioredoxin family
E3D00_RS05540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3D00_RS05550	COG0488	(ABC) transporter
E3D00_RS05575	COG1045	serine acetyltransferase
E3D00_RS05580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3D00_RS05590	COG0347	Belongs to the P(II) protein family
E3D00_RS05595	COG0004	ammonium transporteR
E3D00_RS05610	COG4974	Belongs to the 'phage' integrase family
E3D00_RS05630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E3D00_RS05650	COG1566	PFAM secretion protein HlyD family protein
E3D00_RS05665	COG2943	transferase activity, transferring hexosyl groups
E3D00_RS05670	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E3D00_RS05675	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3D00_RS05675	COG4106	trans-aconitate 2-methyltransferase activity
E3D00_RS05690	COG0156	8-amino-7-oxononanoate synthase activity
E3D00_RS05705	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E3D00_RS05745	COG1216	Glycosyl transferase, family 2
E3D00_RS05745	COG0438	transferase activity, transferring glycosyl groups
E3D00_RS05755	COG0581	inorganic phosphate transmembrane transporter activity
E3D00_RS05760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3D00_RS05770	COG0745	RESPONSE REGULATOR receiver
E3D00_RS05780	COG0784	Response regulator, receiver
E3D00_RS05790	COG0784	Response regulator, receiver
E3D00_RS05790	COG4191	Histidine kinase
E3D00_RS05875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3D00_RS05885	COG0438	transferase activity, transferring glycosyl groups
E3D00_RS05895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3D00_RS05900	COG2945	thiolester hydrolase activity
E3D00_RS05910	COG1104	cysteine desulfurase activity
E3D00_RS05920	COG0482	sulfurtransferase activity
E3D00_RS05935	COG1280	lysine exporter protein (LysE YggA)
E3D00_RS05940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3D00_RS05955	COG2983	Belongs to the UPF0260 family
E3D00_RS05970	COG3842	ATPase activity
E3D00_RS05990	COG1566	PFAM secretion protein HlyD family protein
E3D00_RS05995	COG1538	Outer membrane efflux protein
E3D00_RS06010	COG3104	oligopeptide transport
E3D00_RS06070	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E3D00_RS06080	COG1289	transmembrane transporter activity
E3D00_RS06120	COG1073	alpha beta
E3D00_RS06125	COG1073	alpha beta
E3D00_RS06130	COG0583	DNA-binding transcription factor activity
E3D00_RS06165	COG4104	PAAR repeat-containing protein
E3D00_RS06205	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E3D00_RS06215	COG0489	protein tyrosine kinase activity
E3D00_RS06230	COG0246	Mannitol dehydrogenase
E3D00_RS06235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E3D00_RS06245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E3D00_RS06250	COG0384	phenazine biosynthesis protein PhzF
E3D00_RS06255	COG0343	queuine tRNA-ribosyltransferase activity
E3D00_RS06260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E3D00_RS06265	COG3956	TIGRFAM MazG family protein
E3D00_RS06285	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E3D00_RS06290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E3D00_RS06295	COG0552	protein localization to endoplasmic reticulum
E3D00_RS06300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3D00_RS06305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E3D00_RS06310	COG2226	methyltransferase
E3D00_RS06320	COG2326	polyphosphate kinase activity
E3D00_RS06325	COG4221	oxidoreductase activity
E3D00_RS06330	COG1678	Uncharacterized ACR, COG1678
E3D00_RS06335	COG0667	Aldo Keto reductase
E3D00_RS06340	COG0542	response to heat
E3D00_RS06370	COG0300	oxidoreductase activity
E3D00_RS06375	COG2207	Transcriptional regulator
E3D00_RS06380	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E3D00_RS06435	COG0523	cobalamin synthesis protein
E3D00_RS06455	COG0671	phosphoesterase, PA-phosphatase related
E3D00_RS06470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3D00_RS06480	COG2862	Uncharacterized protein family, UPF0114
E3D00_RS06485	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E3D00_RS06500	COG0156	8-amino-7-oxononanoate synthase activity
E3D00_RS06510	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E3D00_RS06525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E3D00_RS06530	COG4251	negative regulation of phosphorylation
E3D00_RS06540	COG0114	fumarate hydratase activity
E3D00_RS06565	COG3088	subunit of a heme lyase
E3D00_RS06570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3D00_RS06575	COG1138	Cytochrome C-type biogenesis protein
E3D00_RS06580	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E3D00_RS06610	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E3D00_RS06630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3D00_RS06640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3D00_RS06645	COG0564	pseudouridine synthase activity
E3D00_RS06660	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E3D00_RS06660	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E3D00_RS06685	COG1252	NADH dehydrogenase
E3D00_RS06690	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E3D00_RS06695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3D00_RS06700	COG0653	protein targeting
E3D00_RS06705	COG0217	transcriptional regulatory protein
E3D00_RS06710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E3D00_RS06715	COG0632	four-way junction helicase activity
E3D00_RS06720	COG2255	four-way junction helicase activity
E3D00_RS06725	COG0824	Thioesterase
E3D00_RS06730	COG0811	peptide transport
E3D00_RS06735	COG0848	biopolymer transport protein
E3D00_RS06745	COG0823	Involved in the tonB-independent uptake of proteins
E3D00_RS06750	COG2885	chlorophyll binding
E3D00_RS06760	COG0037	tRNA processing
E3D00_RS06770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3D00_RS06775	COG0351	phosphomethylpyrimidine kinase
E3D00_RS06775	COG0352	thiamine-phosphate diphosphorylase activity
E3D00_RS06780	COG0745	RESPONSE REGULATOR receiver
E3D00_RS06800	COG2309	aminopeptidase activity
E3D00_RS06815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3D00_RS06835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3D00_RS06840	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E3D00_RS06845	COG0561	phosphatase activity
E3D00_RS06850	COG0363	glucosamine-6-phosphate deaminase activity
E3D00_RS06855	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E3D00_RS06860	COG3265	gluconokinase activity
E3D00_RS06865	COG1671	Belongs to the UPF0178 family
E3D00_RS06870	COG0588	phosphoglycerate mutase activity
E3D00_RS06875	COG3264	Mechanosensitive ion channel
E3D00_RS06875	COG1196	nuclear chromosome segregation
E3D00_RS06880	COG0167	dihydroorotate dehydrogenase activity
E3D00_RS06895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E3D00_RS06900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E3D00_RS06925	COG2204	response regulator
E3D00_RS06930	COG1923	regulation of RNA biosynthetic process
E3D00_RS06935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3D00_RS06955	COG0659	secondary active sulfate transmembrane transporter activity
E3D00_RS06980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E3D00_RS06985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E3D00_RS06990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3D00_RS07000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3D00_RS07005	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E3D00_RS07005	COG3608	succinylglutamate desuccinylase aspartoacylase
E3D00_RS07010	COG0303	'Molybdopterin
E3D00_RS07015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E3D00_RS07020	COG0315	cyclic pyranopterin monophosphate synthase activity
E3D00_RS07025	COG0746	molybdenum cofactor guanylyltransferase activity
E3D00_RS07025	COG0315	cyclic pyranopterin monophosphate synthase activity
E3D00_RS07035	COG0314	molybdopterin synthase activity
E3D00_RS07050	COG1295	ribonuclease BN
E3D00_RS07065	COG0511	ligase activity, forming carbon-carbon bonds
E3D00_RS07070	COG0439	Biotin carboxylase
E3D00_RS07080	COG0129	dihydroxy-acid dehydratase activity
E3D00_RS07085	COG0800	Aldolase
E3D00_RS07090	COG1988	membrane-bound metal-dependent
E3D00_RS07095	COG0138	bifunctional purine biosynthesis protein purh
E3D00_RS07110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E3D00_RS07115	COG1766	The M ring may be actively involved in energy transduction
E3D00_RS07120	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3D00_RS07130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3D00_RS07135	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3D00_RS07140	COG1419	protein localization to endoplasmic reticulum
E3D00_RS07145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3D00_RS07155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3D00_RS07160	COG0679	Auxin Efflux Carrier
E3D00_RS07185	COG0564	pseudouridine synthase activity
E3D00_RS07195	COG0640	Transcriptional regulator
E3D00_RS07200	COG1902	pentaerythritol trinitrate reductase activity
E3D00_RS07530	COG3750	Belongs to the UPF0335 family
E3D00_RS07560	COG0629	single-stranded DNA binding
E3D00_RS07645	COG2267	carboxylic ester hydrolase activity
E3D00_RS07650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3D00_RS07650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3D00_RS07660	COG0747	negative chemotaxis
E3D00_RS07670	COG1570	exodeoxyribonuclease VII activity
E3D00_RS07680	COG1530	ribonuclease E activity
E3D00_RS07685	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3D00_RS07690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3D00_RS07695	COG0730	response to heat
E3D00_RS07725	COG0768	penicillin binding
E3D00_RS07730	COG0772	Belongs to the SEDS family
E3D00_RS07740	COG0751	glycine-tRNA ligase activity
E3D00_RS07745	COG0752	glycyl-tRNA synthetase alpha subunit
E3D00_RS07760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E3D00_RS07775	COG0316	Belongs to the HesB IscA family
E3D00_RS07780	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E3D00_RS07785	COG0018	arginyl-trna synthetase
E3D00_RS07795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E3D00_RS07800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E3D00_RS07805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3D00_RS07810	COG0805	protein transport
E3D00_RS07815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E3D00_RS07845	COG2267	carboxylic ester hydrolase activity
E3D00_RS07855	COG3145	DNA-N1-methyladenine dioxygenase activity
E3D00_RS07860	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E3D00_RS07875	COG2084	Dehydrogenase
E3D00_RS07880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3D00_RS07895	COG0215	cysteine-tRNA ligase activity
E3D00_RS07910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E3D00_RS07915	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E3D00_RS07940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E3D00_RS07950	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3D00_RS07950	COG2885	chlorophyll binding
E3D00_RS07955	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E3D00_RS07965	COG4974	Belongs to the 'phage' integrase family
E3D00_RS07970	COG0825	malonyl-CoA metabolic process
E3D00_RS07985	COG0494	nUDIX hydrolase
E3D00_RS07995	COG1862	Preprotein translocase
E3D00_RS08010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3D00_RS08015	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E3D00_RS08030	COG1758	RNA polymerase activity
E3D00_RS08040	COG0736	holo-[acyl-carrier-protein] synthase activity
E3D00_RS08045	COG0681	Belongs to the peptidase S26 family
E3D00_RS08050	COG0571	ribonuclease III activity
E3D00_RS08055	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3D00_RS08060	COG0528	UMP kinase activity
E3D00_RS08065	COG0233	cytoplasmic translational termination
E3D00_RS08070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3D00_RS08080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E3D00_RS08085	COG0750	zinc metalloprotease
E3D00_RS08100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3D00_RS08105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3D00_RS08110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3D00_RS08115	COG3494	Protein of unknown function (DUF1009)
E3D00_RS08120	COG0346	lactoylglutathione lyase activity
E3D00_RS08130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E3D00_RS08135	COG0594	ribonuclease P activity
E3D00_RS08140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E3D00_RS08145	COG0706	membrane insertase activity
E3D00_RS08150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E3D00_RS08155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3D00_RS08160	COG2171	N-acyltransferase activity
E3D00_RS08165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3D00_RS08175	COG0101	tRNA pseudouridine synthase activity
E3D00_RS08180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3D00_RS08185	COG0242	peptide deformylase activity
E3D00_RS08205	COG0251	oxidation-reduction process
E3D00_RS08210	COG1137	ATPase activity
E3D00_RS08225	COG0517	IMP dehydrogenase activity
E3D00_RS08225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3D00_RS08260	COG1164	Oligoendopeptidase f
E3D00_RS08265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3D00_RS08275	COG0556	nucleotide-excision repair
E3D00_RS08290	COG0189	ligase activity
E3D00_RS08300	COG2226	methyltransferase
E3D00_RS08310	COG0109	protoheme IX farnesyltransferase activity
E3D00_RS08320	COG0312	modulator of DNA gyrase
E3D00_RS08325	COG0612	Peptidase, M16
E3D00_RS08350	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E3D00_RS08355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3D00_RS08360	COG0728	peptidoglycan biosynthetic process
E3D00_RS08365	COG0386	Belongs to the glutathione peroxidase family
E3D00_RS08370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E3D00_RS08375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E3D00_RS08380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E3D00_RS08385	COG0181	hydroxymethylbilane synthase activity
E3D00_RS08395	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E3D00_RS08415	COG1858	cytochrome C peroxidase
E3D00_RS08430	COG0408	coproporphyrinogen oxidase activity
E3D00_RS08435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E3D00_RS08440	COG0412	Dienelactone hydrolase
E3D00_RS08450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E3D00_RS08455	COG0459	protein refolding
E3D00_RS08465	COG1199	ATP-dependent helicase activity
E3D00_RS08470	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E3D00_RS08475	COG0392	lysyltransferase activity
E3D00_RS08480	COG2095	MarC family integral membrane protein
E3D00_RS08485	COG1573	uracil-dna glycosylase
E3D00_RS08495	COG0670	Belongs to the BI1 family
E3D00_RS08515	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E3D00_RS08525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3D00_RS08525	COG0564	pseudouridine synthase activity
E3D00_RS08535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3D00_RS08570	COG0488	(ABC) transporter
E3D00_RS08575	COG0105	UTP biosynthetic process
E3D00_RS08585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3D00_RS08600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3D00_RS08605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E3D00_RS08615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E3D00_RS08620	COG0248	Ppx GppA phosphatase
E3D00_RS08630	COG2814	Major facilitator Superfamily
E3D00_RS08645	COG0019	diaminopimelate decarboxylase activity
E3D00_RS08655	COG0784	Response regulator, receiver
E3D00_RS08655	COG4191	Histidine kinase
E3D00_RS08675	COG0519	Catalyzes the synthesis of GMP from XMP
E3D00_RS08675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3D00_RS08710	COG0165	Argininosuccinate lyase
E3D00_RS08715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3D00_RS08725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3D00_RS08730	COG0237	dephospho-CoA kinase activity
E3D00_RS08735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3D00_RS08745	COG0438	transferase activity, transferring glycosyl groups
E3D00_RS08750	COG0367	asparagine synthase
E3D00_RS08755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E3D00_RS08780	COG1160	GTP binding
E3D00_RS08785	COG2814	Major facilitator Superfamily
E3D00_RS08790	COG2814	Major facilitator Superfamily
E3D00_RS08810	COG3572	ergothioneine biosynthetic process
E3D00_RS08820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3D00_RS08840	COG1663	tetraacyldisaccharide 4'-kinase activity
E3D00_RS08845	COG1519	Transferase
E3D00_RS08860	COG0259	pyridoxamine-phosphate oxidase activity
E3D00_RS08865	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E3D00_RS08870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E3D00_RS08875	COG1764	response to oxidative stress
E3D00_RS08880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3D00_RS08880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3D00_RS08885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3D00_RS08895	COG0142	geranyltranstransferase activity
E3D00_RS08900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E3D00_RS08905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E3D00_RS08920	COG1605	Chorismate mutase
E3D00_RS08920	COG0287	Prephenate dehydrogenase
E3D00_RS08930	COG1196	nuclear chromosome segregation
E3D00_RS08935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3D00_RS08940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3D00_RS08945	COG1253	flavin adenine dinucleotide binding
E3D00_RS08950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E3D00_RS08955	COG1702	phosphate starvation-inducible protein PhoH
E3D00_RS08960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3D00_RS08970	COG0729	surface antigen
E3D00_RS08980	COG0859	PFAM glycosyl transferase family 9
E3D00_RS08980	COG0457	Tetratricopeptide repeat
E3D00_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
E3D00_RS08990	COG1329	Transcriptional regulator
E3D00_RS08995	COG3781	membrane
E3D00_RS09000	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E3D00_RS09005	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E3D00_RS09010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E3D00_RS09015	COG0354	folic acid binding
E3D00_RS09030	COG1121	(ABC) transporter
E3D00_RS09045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E3D00_RS09095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3D00_RS09105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3D00_RS09110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3D00_RS09115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3D00_RS09125	COG0483	inositol monophosphate 1-phosphatase activity
E3D00_RS09130	COG3507	Belongs to the glycosyl hydrolase 43 family
E3D00_RS09160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3D00_RS09175	COG0156	8-amino-7-oxononanoate synthase activity
E3D00_RS09180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3D00_RS09185	COG0318	PFAM AMP-dependent synthetase and ligase
E3D00_RS09190	COG1648	precorrin-2 dehydrogenase activity
E3D00_RS09190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3D00_RS09195	COG2066	Belongs to the glutaminase family
E3D00_RS09200	COG1914	H( )-stimulated, divalent metal cation uptake system
E3D00_RS09210	COG4221	oxidoreductase activity
E3D00_RS09220	COG0646	methionine synthase
E3D00_RS09220	COG1410	methionine synthase
E3D00_RS09270	COG2837	iron assimilation
E3D00_RS09275	COG1072	(Pantothenic acid kinase))
E3D00_RS09280	COG2824	Alkylphosphonate utilization operon protein PhnA
E3D00_RS09285	COG2259	Doxx family
E3D00_RS09290	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3D00_RS09290	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3D00_RS09290	COG0506	proline dehydrogenase activity
E3D00_RS09300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3D00_RS09310	COG3588	fructose-bisphosphate aldolase
E3D00_RS09325	COG0778	Nitroreductase
E3D00_RS09340	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E3D00_RS09345	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E3D00_RS09390	COG2099	Precorrin-6x reductase
E3D00_RS09410	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E3D00_RS09415	COG1797	cobyrinic acid a,c-diamide synthase activity
E3D00_RS09425	COG1492	cobalamin metabolic process
E3D00_RS09430	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E3D00_RS09445	COG4774	siderophore transport
E3D00_RS09460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3D00_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
E3D00_RS09475	COG2814	Major facilitator Superfamily
E3D00_RS09490	COG0116	Belongs to the methyltransferase superfamily
E3D00_RS09505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E3D00_RS09515	COG0306	phosphate transporter
E3D00_RS09555	COG0135	phosphoribosylanthranilate isomerase activity
E3D00_RS09560	COG0284	orotidine-5'-phosphate decarboxylase activity
E3D00_RS09575	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E3D00_RS09590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E3D00_RS09595	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E3D00_RS09615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3D00_RS09630	COG0469	pyruvate kinase activity
E3D00_RS09635	COG0287	Prephenate dehydrogenase
E3D00_RS09645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3D00_RS09650	COG0463	Glycosyl transferase, family 2
E3D00_RS09655	COG1562	ergosterol biosynthetic process
E3D00_RS09660	COG1562	ergosterol biosynthetic process
E3D00_RS09665	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E3D00_RS09670	COG1657	PFAM Prenyltransferase squalene oxidase
E3D00_RS09680	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E3D00_RS09700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3D00_RS09700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3D00_RS09715	COG0745	RESPONSE REGULATOR receiver
E3D00_RS09730	COG0322	excinuclease ABC activity
E3D00_RS09735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3D00_RS09745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3D00_RS09750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3D00_RS09760	COG0148	phosphopyruvate hydratase activity
E3D00_RS09770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E3D00_RS09775	COG0504	CTP synthase activity
E3D00_RS09795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3D00_RS09805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3D00_RS09810	COG0134	indole-3-glycerol-phosphate synthase activity
E3D00_RS09815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3D00_RS09820	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3D00_RS09820	COG0022	dehydrogenase e1 component
E3D00_RS09825	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3D00_RS09830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3D00_RS09835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3D00_RS09850	COG1546	Belongs to the CinA family
E3D00_RS09850	COG1058	Belongs to the CinA family
E3D00_RS09855	COG0741	lytic transglycosylase activity
E3D00_RS09860	COG0861	Integral membrane protein TerC family
E3D00_RS09865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3D00_RS09870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E3D00_RS09875	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3D00_RS09885	COG0047	phosphoribosylformylglycinamidine synthase activity
E3D00_RS09890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3D00_RS09900	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3D00_RS09910	COG0792	nuclease activity
E3D00_RS09915	COG0113	porphobilinogen synthase activity
E3D00_RS09920	COG0531	amino acid
E3D00_RS09925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E3D00_RS09940	COG0513	Belongs to the DEAD box helicase family
E3D00_RS09955	COG1742	UPF0060 membrane protein
E3D00_RS09965	COG0778	Nitroreductase
E3D00_RS09970	COG0131	Imidazoleglycerol-phosphate dehydratase
E3D00_RS09980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3D00_RS09990	COG0107	imidazoleglycerol-phosphate synthase activity
E3D00_RS09995	COG0140	phosphoribosyl-ATP diphosphatase activity
E3D00_RS10025	COG1070	Carbohydrate kinase
E3D00_RS10045	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
E3D00_RS10050	COG2807	transmembrane transport
E3D00_RS10075	COG1741	Belongs to the pirin family
E3D00_RS10085	COG0006	proline dipeptidase activity
E3D00_RS10095	COG2264	protein methyltransferase activity
E3D00_RS10105	COG2003	Belongs to the UPF0758 family
E3D00_RS10110	COG2003	Belongs to the UPF0758 family
E3D00_RS10115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E3D00_RS10120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E3D00_RS10135	COG0071	Belongs to the small heat shock protein (HSP20) family
E3D00_RS10140	COG0254	rRNA binding
E3D00_RS10145	COG1970	mechanosensitive ion channel activity
E3D00_RS10155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3D00_RS10160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3D00_RS10165	COG0673	inositol 2-dehydrogenase activity
E3D00_RS10170	COG0488	(ABC) transporter
E3D00_RS10175	COG0784	Response regulator, receiver
E3D00_RS10195	COG4988	ABC transporter
E3D00_RS10200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3D00_RS10210	COG0514	ATP-dependent DNA helicase (RecQ)
E3D00_RS10220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3D00_RS10225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3D00_RS10230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E3D00_RS10240	COG4221	oxidoreductase activity
E3D00_RS10245	COG0837	glucose binding
E3D00_RS10265	COG0525	valine-tRNA ligase activity
E3D00_RS10270	COG0129	dihydroxy-acid dehydratase activity
E3D00_RS10275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3D00_RS10280	COG1116	anion transmembrane transporter activity
E3D00_RS10290	COG0756	dUTP diphosphatase activity
E3D00_RS10295	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3D00_RS10300	COG2226	methyltransferase
E3D00_RS10305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3D00_RS10310	COG0268	Binds directly to 16S ribosomal RNA
E3D00_RS10440	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3D00_RS10445	COG3657	addiction module killer protein
E3D00_RS10455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII