locus-tag	class	description
STH_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
STH_RS00010	COG0592	DNA-directed DNA polymerase activity
STH_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
STH_RS00030	COG0187	DNA topoisomerase II activity
STH_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
STH_RS00040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
STH_RS00045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
STH_RS00050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
STH_RS00065	COG4166	transmembrane transport
STH_RS00070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
STH_RS00075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
STH_RS00080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
STH_RS00085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
STH_RS00165	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
STH_RS00170	COG0010	Belongs to the arginase family
STH_RS00175	COG0018	arginyl-trna synthetase
STH_RS00180	COG3344	reverse transcriptase
STH_RS00185	COG0659	secondary active sulfate transmembrane transporter activity
STH_RS00190	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
STH_RS00210	COG1765	OsmC-like protein
STH_RS00215	COG1595	DNA-templated transcription, initiation
STH_RS00225	COG1752	Esterase of the alpha-beta hydrolase superfamily
STH_RS00235	COG2814	Major facilitator Superfamily
STH_RS00240	COG0604	alcohol dehydrogenase
STH_RS00255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
STH_RS00260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH_RS00270	COG0504	CTP synthase activity
STH_RS00275	COG1078	dGTPase activity
STH_RS00295	COG1484	DNA-dependent DNA replication
STH_RS00325	COG3267	Type II secretory pathway component ExeA
STH_RS00325	COG3409	Peptidoglycan-binding domain 1 protein
STH_RS00345	COG0793	Belongs to the peptidase S41A family
STH_RS00345	COG3409	Peptidoglycan-binding domain 1 protein
STH_RS00360	COG1607	acyl-coa hydrolase
STH_RS00365	COG3246	L-lysine catabolic process to acetate
STH_RS00375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
STH_RS00380	COG1494	fructose-1,6-bisphosphatase
STH_RS00400	COG0254	rRNA binding
STH_RS00405	COG3872	metal-dependent enzyme
STH_RS00410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
STH_RS00415	COG2890	protein-(glutamine-N5) methyltransferase activity
STH_RS00420	COG0009	L-threonylcarbamoyladenylate synthase
STH_RS00425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
STH_RS00430	COG0698	ribose 5-phosphate isomerase
STH_RS00435	COG4475	Protein of unknown function (DUF436)
STH_RS00440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
STH_RS00445	COG2131	deaminase
STH_RS00450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STH_RS00455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
STH_RS00470	COG0356	it plays a direct role in the translocation of protons across the membrane
STH_RS00475	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
STH_RS00480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
STH_RS00485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
STH_RS00490	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
STH_RS00495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
STH_RS00500	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
STH_RS00505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
STH_RS00515	COG1139	Iron-sulfur cluster binding protein
STH_RS00525	COG1620	l-lactate permease
STH_RS00530	COG2186	Transcriptional regulator
STH_RS00550	COG2385	sporulation resulting in formation of a cellular spore
STH_RS00560	COG1609	Transcriptional regulator
STH_RS00565	COG1077	Cell shape determining protein MreB Mrl
STH_RS00580	COG2391	methyltransferase activity
STH_RS00585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
STH_RS00610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
STH_RS00615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
STH_RS00625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STH_RS00630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
STH_RS00645	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
STH_RS00650	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
STH_RS00655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
STH_RS00665	COG0653	protein targeting
STH_RS00670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH_RS00675	COG0471	metal ion transport
STH_RS00685	COG0601	transmembrane transport
STH_RS00690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS00700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
STH_RS00705	COG0490	domain, Protein
STH_RS00710	COG0475	glutathione-regulated potassium exporter activity
STH_RS00720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
STH_RS00735	COG2884	Cell division ATP-binding protein ftsE
STH_RS00740	COG2177	Part of the ABC transporter FtsEX involved in
STH_RS00750	COG3409	Peptidoglycan-binding domain 1 protein
STH_RS00750	COG0793	Belongs to the peptidase S41A family
STH_RS00765	COG0601	transmembrane transport
STH_RS00770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS00780	COG0601	transmembrane transport
STH_RS00785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS00790	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
STH_RS00795	COG0556	nucleotide-excision repair
STH_RS00820	COG0351	phosphomethylpyrimidine kinase
STH_RS00835	COG0318	PFAM AMP-dependent synthetase and ligase
STH_RS00840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
STH_RS00845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
STH_RS00850	COG1073	alpha beta
STH_RS00865	COG1733	regulation of RNA biosynthetic process
STH_RS00875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
STH_RS00895	COG0322	excinuclease ABC activity
STH_RS00925	COG1950	PFAM Membrane protein of
STH_RS00970	COG1660	Displays ATPase and GTPase activities
STH_RS00975	COG0391	Required for morphogenesis under gluconeogenic growth conditions
STH_RS00985	COG1481	regulation of sporulation
STH_RS00995	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
STH_RS01000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
STH_RS01010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
STH_RS01020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
STH_RS01040	COG5566	PFAM Mor transcription activator
STH_RS01050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STH_RS01060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
STH_RS01075	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
STH_RS01100	COG1024	Enoyl-CoA hydratase
STH_RS01105	COG1250	3-hydroxyacyl-CoA dehydrogenase
STH_RS01125	COG1131	(ABC) transporter
STH_RS01160	COG0745	RESPONSE REGULATOR receiver
STH_RS01180	COG0004	ammonium transporteR
STH_RS01185	COG0067	glutamate synthase
STH_RS01185	COG0070	glutamate synthase
STH_RS01185	COG0069	glutamate synthase activity
STH_RS01190	COG0367	asparagine synthase
STH_RS01205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
STH_RS01220	COG0573	inorganic phosphate transmembrane transporter activity
STH_RS01230	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
STH_RS01240	COG0583	DNA-binding transcription factor activity
STH_RS01245	COG0126	phosphoglycerate kinase activity
STH_RS01255	COG0149	triose-phosphate isomerase activity
STH_RS01260	COG1937	Protein conserved in bacteria
STH_RS01275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
STH_RS01280	COG0148	phosphopyruvate hydratase activity
STH_RS01285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
STH_RS01300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
STH_RS01305	COG2011	ABC-type metal ion transport system permease component
STH_RS01310	COG1464	Belongs to the NlpA lipoprotein family
STH_RS01325	COG0367	asparagine synthase
STH_RS01435	COG3314	Sporulation integral membrane protein YlbJ
STH_RS01480	COG4584	PFAM Integrase catalytic
STH_RS01485	COG1484	DNA-dependent DNA replication
STH_RS01490	COG1484	DNA-dependent DNA replication
STH_RS01500	COG3328	transposase activity
STH_RS01550	COG4447	cellulose binding
STH_RS01555	COG2971	BadF BadG BcrA BcrD
STH_RS01575	COG4608	Belongs to the ABC transporter superfamily
STH_RS01580	COG0444	Belongs to the ABC transporter superfamily
STH_RS01590	COG0601	transmembrane transport
STH_RS01595	COG1472	Belongs to the glycosyl hydrolase 3 family
STH_RS01600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
STH_RS01605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
STH_RS01610	COG3876	Protein conserved in bacteria
STH_RS01665	COG0823	Involved in the tonB-independent uptake of proteins
STH_RS01665	COG1506	peptidase
STH_RS01665	COG4946	Tricorn protease homolog
STH_RS01675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
STH_RS01680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
STH_RS01755	COG0557	exoribonuclease II activity
STH_RS01760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
STH_RS01765	COG1846	Transcriptional regulator
STH_RS01770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
STH_RS01775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
STH_RS01780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
STH_RS01785	COG0622	Phosphoesterase
STH_RS01820	COG2155	Conserved Protein
STH_RS01840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
STH_RS01845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
STH_RS01845	COG2190	(PTS) system
STH_RS01845	COG1263	PTS System
STH_RS01850	COG3711	transcriptional antiterminator
STH_RS01855	COG1160	GTP binding
STH_RS01860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
STH_RS01865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
STH_RS01875	COG0446	pyridine nucleotide-disulphide oxidoreductase
STH_RS01880	COG0544	peptidyl-prolyl cis-trans isomerase activity
STH_RS01885	COG0740	serine-type endopeptidase activity
STH_RS01890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
STH_RS01895	COG0470	DNA polymerase III
STH_RS01895	COG1067	ATP-dependent peptidase activity
STH_RS01900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
STH_RS01905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
STH_RS01925	COG0525	valine-tRNA ligase activity
STH_RS01945	COG0424	maF-like protein
STH_RS01950	COG2003	Belongs to the UPF0758 family
STH_RS01955	COG1077	Cell shape determining protein MreB Mrl
STH_RS01970	COG0850	regulation of cytokinetic process
STH_RS01975	COG2894	cell division
STH_RS01980	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
STH_RS01990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
STH_RS02005	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
STH_RS02030	COG2894	cell division
STH_RS02040	COG0489	protein tyrosine kinase activity
STH_RS02140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
STH_RS02145	COG0640	Transcriptional regulator
STH_RS02170	COG0745	RESPONSE REGULATOR receiver
STH_RS02175	COG2205	protein histidine kinase activity
STH_RS02205	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
STH_RS02215	COG1032	radical SAM domain protein
STH_RS02235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
STH_RS02245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
STH_RS02250	COG2868	ribosomal protein
STH_RS02255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
STH_RS02260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
STH_RS02270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
STH_RS02275	COG1713	HD superfamily hydrolase involved in NAD metabolism
STH_RS02280	COG0799	negative regulation of ribosome biogenesis
STH_RS02285	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
STH_RS02290	COG3290	protein histidine kinase activity
STH_RS02290	COG3829	transcription factor binding
STH_RS02295	COG3033	Beta-eliminating lyase
STH_RS02305	COG3033	Beta-eliminating lyase
STH_RS02310	COG0733	neurotransmitter:sodium symporter activity
STH_RS02315	COG0495	leucyl-tRNA aminoacylation
STH_RS02335	COG1361	Conserved repeat domain
STH_RS02350	COG0179	Fumarylacetoacetate (FAA) hydrolase
STH_RS02355	COG1132	(ABC) transporter
STH_RS02360	COG1132	(ABC) transporter
STH_RS02390	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
STH_RS02405	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
STH_RS02410	COG0714	Associated with various cellular activities
STH_RS02440	COG1177	transmembrane transport
STH_RS02445	COG1176	ABC-type spermidine putrescine transport system, permease component I
STH_RS02450	COG3842	ATPase activity
STH_RS02460	COG0658	competence protein
STH_RS02460	COG2333	competence protein COMEC
STH_RS02475	COG0268	Binds directly to 16S ribosomal RNA
STH_RS02490	COG1388	LysM domain
STH_RS02490	COG3858	chitin binding
STH_RS02510	COG0481	GTPase activity
STH_RS02515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
STH_RS02525	COG0165	Argininosuccinate lyase
STH_RS02535	COG0765	amino acid transport
STH_RS02540	COG0765	amino acid transport
STH_RS02545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
STH_RS02555	COG2197	response regulator
STH_RS02565	COG0746	molybdenum cofactor guanylyltransferase activity
STH_RS02595	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
STH_RS02600	COG0519	Catalyzes the synthesis of GMP from XMP
STH_RS02600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
STH_RS02605	COG1420	regulation of RNA biosynthetic process
STH_RS02615	COG0443	Heat shock 70 kDa protein
STH_RS02620	COG0484	heat shock protein binding
STH_RS02630	COG2264	protein methyltransferase activity
STH_RS02635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
STH_RS02655	COG1181	Belongs to the D-alanine--D-alanine ligase family
STH_RS02660	COG0537	adenosine 5'-monophosphoramidase activity
STH_RS02665	COG0828	Belongs to the bacterial ribosomal protein bS21 family
STH_RS02670	COG1610	YqeY-like protein
STH_RS02685	COG0243	molybdopterin cofactor binding
STH_RS02690	COG1030	water channel activity
STH_RS02695	COG4864	UPF0365 protein
STH_RS02740	COG1702	phosphate starvation-inducible protein PhoH
STH_RS02745	COG1480	7TM receptor with intracellular HD hydrolase
STH_RS02750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
STH_RS02755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
STH_RS02765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
STH_RS02770	COG1979	alcohol dehydrogenase
STH_RS02780	COG3858	chitin binding
STH_RS02780	COG1388	LysM domain
STH_RS02790	COG2239	Acts as a magnesium transporter
STH_RS02800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
STH_RS02805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
STH_RS02810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS02840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH_RS02845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
STH_RS02855	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
STH_RS02860	COG3457	Alanine racemase
STH_RS02865	COG1735	metal-dependent hydrolase with the TIM-barrel fold
STH_RS02880	COG2188	Transcriptional regulator
STH_RS02890	COG0626	cystathionine gamma-synthase activity
STH_RS02905	COG2222	sugar isomerase
STH_RS02910	COG2188	Transcriptional regulator
STH_RS02920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
STH_RS02935	COG1381	Involved in DNA repair and RecF pathway recombination
STH_RS02945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS02960	COG4124	Belongs to the glycosyl hydrolase 26 family
STH_RS02965	COG0752	glycyl-tRNA synthetase alpha subunit
STH_RS02970	COG0751	glycine-tRNA ligase activity
STH_RS03010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
STH_RS03015	COG0508	dehydrogenase complex catalyzes the overall conversion of
STH_RS03020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
STH_RS03025	COG0574	Belongs to the PEP-utilizing enzyme family
STH_RS03025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STH_RS03030	COG0358	DNA primase activity
STH_RS03035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
STH_RS03040	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
STH_RS03045	COG2224	Isocitrate lyase
STH_RS03080	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
STH_RS03090	COG1408	metallophosphoesterase
STH_RS03100	COG1940	carbohydrate kinase activity
STH_RS03110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
STH_RS03120	COG0363	glucosamine-6-phosphate deaminase activity
STH_RS03125	COG0577	efflux transmembrane transporter activity
STH_RS03130	COG1136	(ABC) transporter
STH_RS03145	COG0210	DNA helicase
STH_RS03150	COG2096	Adenosyltransferase
STH_RS03170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
STH_RS03185	COG0318	PFAM AMP-dependent synthetase and ligase
STH_RS03205	COG0247	lactate metabolic process
STH_RS03205	COG2181	nitrate reductase activity
STH_RS03225	COG1393	Belongs to the ArsC family
STH_RS03235	COG0535	radical SAM domain protein
STH_RS03250	COG1132	(ABC) transporter
STH_RS03255	COG1132	(ABC) transporter
STH_RS03265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
STH_RS03270	COG3876	Protein conserved in bacteria
STH_RS03285	COG0778	Nitroreductase
STH_RS03300	COG1104	cysteine desulfurase activity
STH_RS03305	COG1271	oxidase subunit
STH_RS03310	COG1294	oxidase, subunit
STH_RS03325	COG1012	belongs to the aldehyde dehydrogenase family
STH_RS03330	COG0842	Transport permease protein
STH_RS03350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
STH_RS03355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STH_RS03360	COG1120	ATPase activity
STH_RS03380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
STH_RS03385	COG0656	L-ascorbic acid biosynthetic process
STH_RS03430	COG1857	crispr-associated protein
STH_RS03470	COG1136	(ABC) transporter
STH_RS03470	COG0577	efflux transmembrane transporter activity
STH_RS03485	COG0003	Pfam Anion-transporting ATPase
STH_RS03490	COG0003	Pfam Anion-transporting ATPase
STH_RS03500	COG1966	Carbon starvation protein
STH_RS03515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
STH_RS03530	COG1131	(ABC) transporter
STH_RS03535	COG0745	RESPONSE REGULATOR receiver
STH_RS03545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
STH_RS03570	COG1073	alpha beta
STH_RS03585	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
STH_RS03595	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STH_RS03605	COG0318	PFAM AMP-dependent synthetase and ligase
STH_RS03630	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STH_RS03645	COG0437	4 iron, 4 sulfur cluster binding
STH_RS03650	COG0243	molybdopterin cofactor binding
STH_RS03675	COG1404	Belongs to the peptidase S8 family
STH_RS03675	COG4412	M6 family metalloprotease domain protein
STH_RS03680	COG2718	Belongs to the UPF0229 family
STH_RS03685	COG0183	Belongs to the thiolase family
STH_RS03695	COG1012	belongs to the aldehyde dehydrogenase family
STH_RS03700	COG0840	transmembrane signaling receptor activity
STH_RS03705	COG2719	SpoVR family
STH_RS03730	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
STH_RS03740	COG0745	RESPONSE REGULATOR receiver
STH_RS03745	COG2205	protein histidine kinase activity
STH_RS03745	COG2202	Pas domain
STH_RS03755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH_RS03760	COG1333	cytochrome c biogenesis protein
STH_RS03765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
STH_RS03770	COG1164	Oligoendopeptidase f
STH_RS03800	COG3344	reverse transcriptase
STH_RS03805	COG0704	Plays a role in the regulation of phosphate uptake
STH_RS03810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
STH_RS03815	COG0581	inorganic phosphate transmembrane transporter activity
STH_RS03820	COG0573	inorganic phosphate transmembrane transporter activity
STH_RS03825	COG5002	protein histidine kinase activity
STH_RS03830	COG0745	RESPONSE REGULATOR receiver
STH_RS03835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
STH_RS03930	COG1404	Belongs to the peptidase S8 family
STH_RS03940	COG0534	Mate efflux family protein
STH_RS03950	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
STH_RS03960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
STH_RS03970	COG0573	inorganic phosphate transmembrane transporter activity
STH_RS03975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
STH_RS04005	COG1609	Transcriptional regulator
STH_RS04010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STH_RS04015	COG1869	D-ribose catabolic process
STH_RS04020	COG1129	ABC transporter
STH_RS04030	COG0006	proline dipeptidase activity
STH_RS04050	COG0438	transferase activity, transferring glycosyl groups
STH_RS04055	COG0438	transferase activity, transferring glycosyl groups
STH_RS04060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
STH_RS04070	COG5337	Spore coat protein CotH
STH_RS04085	COG0647	UMP catabolic process
STH_RS04095	COG2766	serine protein kinase
STH_RS04115	COG1349	DNA-binding transcription factor activity
STH_RS04125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
STH_RS04125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
STH_RS04125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH_RS04140	COG0318	PFAM AMP-dependent synthetase and ligase
STH_RS04170	COG0183	Belongs to the thiolase family
STH_RS04185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STH_RS04205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
STH_RS04210	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
STH_RS04215	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
STH_RS04220	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
STH_RS04225	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
STH_RS04230	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
STH_RS04270	COG0561	phosphatase activity
STH_RS04285	COG1988	membrane-bound metal-dependent
STH_RS04305	COG1027	Aspartate ammonia-lyase
STH_RS04310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
STH_RS04310	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
STH_RS04335	COG0824	Thioesterase
STH_RS04340	COG0489	protein tyrosine kinase activity
STH_RS04340	COG2151	metal-sulfur cluster biosynthetic enzyme
STH_RS04355	COG5002	protein histidine kinase activity
STH_RS04360	COG0745	RESPONSE REGULATOR receiver
STH_RS04380	COG3344	reverse transcriptase
STH_RS04390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
STH_RS04400	COG0237	dephospho-CoA kinase activity
STH_RS04425	COG4181	ATPase activity
STH_RS04445	COG1331	Highly conserved protein containing a thioredoxin domain
STH_RS04450	COG3773	Cell wall hydrolase
STH_RS04465	COG0426	domain, Protein
STH_RS04465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
STH_RS04490	COG0534	Mate efflux family protein
STH_RS04500	COG1116	anion transmembrane transporter activity
STH_RS04505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
STH_RS04530	COG3344	reverse transcriptase
STH_RS04535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STH_RS04545	COG2843	Capsule synthesis protein
STH_RS04555	COG2226	methyltransferase
STH_RS04560	COG1201	RNA secondary structure unwinding
STH_RS04580	COG2814	Major facilitator Superfamily
STH_RS04595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
STH_RS04600	COG3344	reverse transcriptase
STH_RS04610	COG4656	Part of a membrane complex involved in electron transport
STH_RS04615	COG4658	electron transport chain
STH_RS04620	COG4659	FMN binding
STH_RS04625	COG4660	Part of a membrane complex involved in electron transport
STH_RS04630	COG4657	Part of a membrane complex involved in electron transport
STH_RS04635	COG1245	4Fe-4S binding domain
STH_RS04635	COG2878	Part of a membrane complex involved in electron transport
STH_RS04655	COG4946	Tricorn protease homolog
STH_RS04655	COG0823	Involved in the tonB-independent uptake of proteins
STH_RS04655	COG1506	peptidase
STH_RS04660	COG1595	DNA-templated transcription, initiation
STH_RS04670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
STH_RS04685	COG0612	Peptidase, M16
STH_RS04690	COG0740	serine-type endopeptidase activity
STH_RS04700	COG0437	4 iron, 4 sulfur cluster binding
STH_RS04705	COG0243	molybdopterin cofactor binding
STH_RS04735	COG2197	response regulator
STH_RS04740	COG0589	response to stress
STH_RS04755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH_RS04770	COG0069	glutamate synthase activity
STH_RS04780	COG1942	4-Oxalocrotonate Tautomerase
STH_RS04790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
STH_RS04800	COG2318	DinB family
STH_RS04865	COG1489	DNA binding
STH_RS04880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
STH_RS04890	COG2723	6-phospho-beta-galactosidase activity
STH_RS04895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH_RS04895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STH_RS04900	COG4946	Tricorn protease homolog
STH_RS04900	COG0823	Involved in the tonB-independent uptake of proteins
STH_RS04900	COG1506	peptidase
STH_RS04910	COG1253	flavin adenine dinucleotide binding
STH_RS04915	COG0501	Belongs to the peptidase M48B family
STH_RS04920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
STH_RS04935	COG1252	NADH dehydrogenase
STH_RS04945	COG0492	ferredoxin-NADP+ reductase activity
STH_RS04960	COG1028	Short-chain dehydrogenase reductase Sdr
STH_RS04965	COG1361	Conserved repeat domain
STH_RS04975	COG2050	protein possibly involved in aromatic compounds catabolism
STH_RS05000	COG1136	(ABC) transporter
STH_RS05005	COG0577	efflux transmembrane transporter activity
STH_RS05030	COG0730	response to heat
STH_RS05035	COG0316	Belongs to the HesB IscA family
STH_RS05040	COG3344	reverse transcriptase
STH_RS05045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STH_RS05050	COG3275	phosphorelay sensor kinase activity
STH_RS05055	COG3279	Response regulator of the LytR AlgR family
STH_RS05070	COG0302	gtp cyclohydrolase
STH_RS05080	COG0247	lactate metabolic process
STH_RS05085	COG0277	FAD linked oxidase domain protein
STH_RS05105	COG4149	molybdate abc transporter
STH_RS05120	COG0626	cystathionine gamma-synthase activity
STH_RS05125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
STH_RS05130	COG4085	toxin activity
STH_RS05130	COG0737	Belongs to the 5'-nucleotidase family
STH_RS05130	COG1525	nuclease
STH_RS05140	COG0217	transcriptional regulatory protein
STH_RS05145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
STH_RS05160	COG0166	Belongs to the GPI family
STH_RS05165	COG0724	RNA recognition motif
STH_RS05170	COG2059	Chromate
STH_RS05185	COG0726	polysaccharide deacetylase
STH_RS05245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STH_RS05260	COG1151	hydroxylamine reductase activity
STH_RS05275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
STH_RS05280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
STH_RS05290	COG1217	gtp-binding protein TYPA
STH_RS05300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS05305	COG0601	transmembrane transport
STH_RS05320	COG2205	protein histidine kinase activity
STH_RS05320	COG0784	Response regulator, receiver
STH_RS05320	COG5002	protein histidine kinase activity
STH_RS05325	COG0745	RESPONSE REGULATOR receiver
STH_RS05335	COG4166	transmembrane transport
STH_RS05345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
STH_RS05370	COG1801	Protein of unknown function DUF72
STH_RS05375	COG1595	DNA-templated transcription, initiation
STH_RS05390	COG0617	tRNA 3'-terminal CCA addition
STH_RS05410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
STH_RS05415	COG0765	amino acid transport
STH_RS05440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
STH_RS05465	COG1575	Belongs to the MenA family. Type 1 subfamily
STH_RS05470	COG0492	ferredoxin-NADP+ reductase activity
STH_RS05490	COG1876	peptidase activity
STH_RS05505	COG1683	Conserved Protein
STH_RS05510	COG1363	Peptidase, m42
STH_RS05515	COG1363	Peptidase, m42
STH_RS05525	COG0840	transmembrane signaling receptor activity
STH_RS05535	COG0805	protein transport
STH_RS05540	COG0488	(ABC) transporter
STH_RS05565	COG2959	enzyme of heme biosynthesis
STH_RS05575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
STH_RS05580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
STH_RS05585	COG0569	domain protein
STH_RS05590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
STH_RS05595	COG0569	domain protein
STH_RS05600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
STH_RS05625	COG0728	peptidoglycan biosynthetic process
STH_RS05635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
STH_RS05640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STH_RS05640	COG0072	phenylalanine-tRNA ligase activity
STH_RS05650	COG0601	transmembrane transport
STH_RS05655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS05660	COG0444	Belongs to the ABC transporter superfamily
STH_RS05665	COG4608	Belongs to the ABC transporter superfamily
STH_RS05710	COG0488	(ABC) transporter
STH_RS05715	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
STH_RS05720	COG1193	negative regulation of DNA recombination
STH_RS05725	COG1078	dGTPase activity
STH_RS05755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
STH_RS05765	COG3344	reverse transcriptase
STH_RS05775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
STH_RS05790	COG3328	transposase activity
STH_RS05830	COG0175	sulfate reduction
STH_RS05835	COG2046	Belongs to the sulfate adenylyltransferase family
STH_RS05840	COG3842	ATPase activity
STH_RS05855	COG1473	amidohydrolase
STH_RS05860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
STH_RS05890	COG4149	molybdate abc transporter
STH_RS05895	COG3842	ATPase activity
STH_RS05900	COG1840	ABC-type Fe3 transport system, periplasmic component
STH_RS05905	COG1316	TRANSCRIPTIONal
STH_RS05910	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
STH_RS05915	COG0632	four-way junction helicase activity
STH_RS05920	COG2255	four-way junction helicase activity
STH_RS05925	COG1191	sigma factor activity
STH_RS05940	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
STH_RS05945	COG0343	queuine tRNA-ribosyltransferase activity
STH_RS05955	COG1862	Preprotein translocase
STH_RS05965	COG2719	SpoVR family
STH_RS05970	COG2718	Belongs to the UPF0229 family
STH_RS05975	COG2766	serine protein kinase
STH_RS06005	COG2197	response regulator
STH_RS06045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH_RS06045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH_RS06050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH_RS06050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH_RS06055	COG0346	lactoylglutathione lyase activity
STH_RS06060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
STH_RS06065	COG0511	ligase activity, forming carbon-carbon bonds
STH_RS06065	COG5016	pyruvate
STH_RS06075	COG0439	Biotin carboxylase
STH_RS06080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
STH_RS06095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
STH_RS06120	COG2001	Belongs to the MraZ family
STH_RS06125	COG0275	rRNA processing
STH_RS06135	COG0505	Belongs to the CarA family
STH_RS06140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
STH_RS06150	COG0768	penicillin binding
STH_RS06155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
STH_RS06165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STH_RS06170	COG0772	Belongs to the SEDS family
STH_RS06175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
STH_RS06180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
STH_RS06185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
STH_RS06200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
STH_RS06205	COG3879	Bacterial protein of unknown function (DUF881)
STH_RS06210	COG3856	small basic protein
STH_RS06220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
STH_RS06230	COG1191	sigma factor activity
STH_RS06235	COG1191	sigma factor activity
STH_RS06260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
STH_RS06265	COG1799	cell septum assembly
STH_RS06275	COG3599	regulation of cell shape
STH_RS06280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
STH_RS06285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STH_RS06290	COG1079	Belongs to the binding-protein-dependent transport system permease family
STH_RS06295	COG4603	Belongs to the binding-protein-dependent transport system permease family
STH_RS06300	COG3845	ABC transporter
STH_RS06305	COG1744	ABC transporter substrate-binding protein PnrA-like
STH_RS06310	COG1574	metal-dependent hydrolase with the TIM-barrel fold
STH_RS06320	COG0747	negative chemotaxis
STH_RS06330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
STH_RS06335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
STH_RS06340	COG0564	pseudouridine synthase activity
STH_RS06345	COG0284	orotidine-5'-phosphate decarboxylase activity
STH_RS06360	COG3716	PTS system mannose fructose sorbose family IID component
STH_RS06370	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
STH_RS06385	COG2222	sugar isomerase
STH_RS06390	COG1960	acyl-CoA dehydrogenase activity
STH_RS06405	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
STH_RS06410	COG0540	Belongs to the ATCase OTCase family
STH_RS06415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
STH_RS06420	COG0543	2 iron, 2 sulfur cluster binding
STH_RS06425	COG0167	dihydroorotate dehydrogenase activity
STH_RS06430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
STH_RS06450	COG0393	Putative heavy-metal-binding
STH_RS06470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
STH_RS06480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STH_RS06485	COG0724	RNA recognition motif
STH_RS06505	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
STH_RS06505	COG3933	PFAM sigma-54 factor interaction domain-containing protein
STH_RS06510	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
STH_RS06510	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH_RS06515	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH_RS06520	COG3716	PTS system mannose fructose sorbose family IID component
STH_RS06530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
STH_RS06540	COG1120	ATPase activity
STH_RS06545	COG1120	ATPase activity
STH_RS06550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STH_RS06555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STH_RS06600	COG1484	DNA-dependent DNA replication
STH_RS06635	COG0210	DNA helicase
STH_RS06650	COG0270	DNA (cytosine-5-)-methyltransferase activity
STH_RS06655	COG1653	transport
STH_RS06660	COG1175	transmembrane transport
STH_RS06665	COG0395	ABC-type sugar transport system, permease component
STH_RS06675	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
STH_RS06680	COG1013	pyruvate-flavodoxin oxidoreductase activity
STH_RS06685	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
STH_RS06685	COG0674	pyruvate-flavodoxin oxidoreductase activity
STH_RS06700	COG1361	Conserved repeat domain
STH_RS06740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
STH_RS06765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
STH_RS06775	COG1561	YicC-like family, N-terminal region
STH_RS06780	COG2052	Domain of unknown function (DUF370)
STH_RS06785	COG0194	GDP metabolic process
STH_RS06790	COG1758	RNA polymerase activity
STH_RS06795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
STH_RS06800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
STH_RS06805	COG0242	peptide deformylase activity
STH_RS06810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
STH_RS06815	COG2738	Putative neutral zinc metallopeptidase
STH_RS06820	COG3344	reverse transcriptase
STH_RS06835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
STH_RS06835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
STH_RS06845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
STH_RS06850	COG0631	protein serine/threonine phosphatase activity
STH_RS06855	COG0515	serine threonine protein kinase
STH_RS06855	COG2815	serine threonine protein kinase
STH_RS06860	COG1162	GTPase activity
STH_RS06865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
STH_RS06870	COG0835	chemotaxis
STH_RS06875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
STH_RS06880	COG0227	Belongs to the bacterial ribosomal protein bL28 family
STH_RS06885	COG1302	Protein conserved in bacteria
STH_RS06890	COG1461	Dihydroxyacetone kinase
STH_RS06895	COG1216	Glycosyl transferase, family 2
STH_RS06900	COG0438	transferase activity, transferring glycosyl groups
STH_RS06910	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
STH_RS06920	COG0438	transferase activity, transferring glycosyl groups
STH_RS06930	COG1088	dTDP-glucose 4,6-dehydratase activity
STH_RS06950	COG0438	transferase activity, transferring glycosyl groups
STH_RS06965	COG0438	transferase activity, transferring glycosyl groups
STH_RS07005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
STH_RS07015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH_RS07025	COG2391	methyltransferase activity
STH_RS07030	COG0425	Belongs to the sulfur carrier protein TusA family
STH_RS07035	COG0693	protein deglycase activity
STH_RS07040	COG1970	mechanosensitive ion channel activity
STH_RS07045	COG0596	Alpha beta hydrolase
STH_RS07045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
STH_RS07105	COG0561	phosphatase activity
STH_RS07110	COG1268	BioY protein
STH_RS07120	COG2814	Major facilitator Superfamily
STH_RS07135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
STH_RS07140	COG1408	metallophosphoesterase
STH_RS07145	COG0180	Tryptophanyl-tRNA synthetase
STH_RS07155	COG0135	phosphoribosylanthranilate isomerase activity
STH_RS07160	COG0133	tryptophan synthase activity
STH_RS07165	COG0159	tryptophan synthase activity
STH_RS07170	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
STH_RS07175	COG0287	Prephenate dehydrogenase
STH_RS07180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
STH_RS07190	COG0840	transmembrane signaling receptor activity
STH_RS07190	COG0840	transmembrane signaling receptor activity
STH_RS07195	COG0747	negative chemotaxis
STH_RS07205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS07210	COG0673	inositol 2-dehydrogenase activity
STH_RS07215	COG1132	(ABC) transporter
STH_RS07250	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
STH_RS07270	COG0742	ribosomal rna small subunit methyltransferase
STH_RS07275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
STH_RS07285	COG3480	Lon protease (S16) C-terminal proteolytic domain
STH_RS07295	COG0454	-acetyltransferase
STH_RS07305	COG2030	dehydratase
STH_RS07310	COG0416	fatty acid biosynthetic process
STH_RS07315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STH_RS07320	COG1307	EDD domain protein, DegV family
STH_RS07325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
STH_RS07330	COG1028	Short-chain dehydrogenase reductase Sdr
STH_RS07335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
STH_RS07340	COG0571	ribonuclease III activity
STH_RS07345	COG2359	stage V sporulation protein S
STH_RS07350	COG1196	nuclear chromosome segregation
STH_RS07355	COG0552	protein localization to endoplasmic reticulum
STH_RS07360	COG0789	Transcriptional regulator
STH_RS07385	COG1694	Mazg nucleotide pyrophosphohydrolase
STH_RS07390	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
STH_RS07395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
STH_RS07400	COG0228	four-way junction DNA binding
STH_RS07405	COG1837	Belongs to the UPF0109 family
STH_RS07415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
STH_RS07420	COG0336	Belongs to the RNA methyltransferase TrmD family
STH_RS07425	COG0335	large ribosomal subunit rRNA binding
STH_RS07440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
STH_RS07445	COG0792	nuclease activity
STH_RS07470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
STH_RS07470	COG0758	DNA mediated transformation
STH_RS07475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
STH_RS07480	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
STH_RS07485	COG4974	Belongs to the 'phage' integrase family
STH_RS07490	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
STH_RS07525	COG0052	Belongs to the universal ribosomal protein uS2 family
STH_RS07530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
STH_RS07535	COG0528	UMP kinase activity
STH_RS07540	COG0233	cytoplasmic translational termination
STH_RS07555	COG4589	Belongs to the CDS family
STH_RS07560	COG0628	permease
STH_RS07565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
STH_RS07570	COG0750	zinc metalloprotease
STH_RS07575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
STH_RS07580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
STH_RS07585	COG1752	Esterase of the alpha-beta hydrolase superfamily
STH_RS07595	COG0803	Belongs to the bacterial solute-binding protein 9 family
STH_RS07600	COG1121	(ABC) transporter
STH_RS07605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
STH_RS07605	COG1321	iron dependent repressor
STH_RS07610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
STH_RS07615	COG1215	transferase activity, transferring glycosyl groups
STH_RS07620	COG1285	pathogenesis
STH_RS07625	COG2176	DNA-directed DNA polymerase activity
STH_RS07655	COG0779	Required for maturation of 30S ribosomal subunits
STH_RS07660	COG0195	Participates in both transcription termination and antitermination
STH_RS07665	COG2740	Nucleic-acid-binding protein implicated in transcription termination
STH_RS07670	COG1358	cellular component organization or biogenesis
STH_RS07675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
STH_RS07680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
STH_RS07685	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
STH_RS07690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
STH_RS07695	COG0196	riboflavin kinase activity
STH_RS07700	COG1187	pseudouridine synthase activity
STH_RS07705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
STH_RS07710	COG1595	DNA-templated transcription, initiation
STH_RS07720	COG1185	polyribonucleotide nucleotidyltransferase activity
STH_RS07725	COG0612	Peptidase, M16
STH_RS07730	COG0756	dUTP diphosphatase activity
STH_RS07740	COG0835	chemotaxis
STH_RS07750	COG2198	Histidine kinase
STH_RS07750	COG0643	Histidine kinase
STH_RS07760	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
STH_RS07765	COG2201	protein-glutamate methylesterase activity
STH_RS07770	COG2201	protein-glutamate methylesterase activity
STH_RS07775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
STH_RS07785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
STH_RS07790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
STH_RS07795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
STH_RS07800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
STH_RS07805	COG0527	aspartate kinase activity
STH_RS07810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
STH_RS07815	COG3344	reverse transcriptase
STH_RS07820	COG3344	reverse transcriptase
STH_RS07845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
STH_RS07855	COG0740	serine-type endopeptidase activity
STH_RS07865	COG0735	belongs to the Fur family
STH_RS07885	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
STH_RS07890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
STH_RS07925	COG1960	acyl-CoA dehydrogenase activity
STH_RS07930	COG0511	ligase activity, forming carbon-carbon bonds
STH_RS07955	COG1024	Enoyl-CoA hydratase
STH_RS07965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
STH_RS07980	COG0017	Asparaginyl-tRNA synthetase
STH_RS07995	COG1686	Belongs to the peptidase S11 family
STH_RS08000	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH_RS08005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH_RS08010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH_RS08015	COG0649	NAD binding
STH_RS08025	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
STH_RS08030	COG1034	ATP synthesis coupled electron transport
STH_RS08035	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
STH_RS08040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH_RS08045	COG0839	Belongs to the complex I subunit 6 family
STH_RS08050	COG0713	ATP synthesis coupled electron transport
STH_RS08055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
STH_RS08060	COG1007	ATP synthesis coupled electron transport
STH_RS08070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
STH_RS08070	COG2207	Transcriptional regulator
STH_RS08075	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STH_RS08080	COG4605	iron ion homeostasis
STH_RS08085	COG4604	ABC transporter, ATP-binding protein
STH_RS08090	COG4607	ABC-type enterochelin transport system periplasmic component
STH_RS08120	COG2195	Cleaves the N-terminal amino acid of tripeptides
STH_RS08135	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
STH_RS08155	COG0411	ABC transporter
STH_RS08165	COG0535	radical SAM domain protein
STH_RS08185	COG1205	dead DEAH box helicase
STH_RS08185	COG1111	helicase
STH_RS08190	COG0438	transferase activity, transferring glycosyl groups
STH_RS08195	COG2217	Heavy metal translocating P-type atpase
STH_RS08215	COG1131	(ABC) transporter
STH_RS08230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STH_RS08235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
STH_RS08255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH_RS08275	COG0697	spore germination
STH_RS08280	COG1546	Belongs to the CinA family
STH_RS08280	COG1058	Belongs to the CinA family
STH_RS08285	COG1940	carbohydrate kinase activity
STH_RS08295	COG1803	Methylglyoxal synthase
STH_RS08300	COG0513	Belongs to the DEAD box helicase family
STH_RS08320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
STH_RS08335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
STH_RS08335	COG2111	Na H antiporter
STH_RS08340	COG2111	Na H antiporter
STH_RS08345	COG1006	Multisubunit Na H antiporter MnhC subunit
STH_RS08350	COG0651	ATP synthesis coupled electron transport
STH_RS08355	COG1863	multisubunit Na H antiporter MnhE subunit
STH_RS08360	COG2212	antiporter activity
STH_RS08365	COG1320	monovalent cation:proton antiporter activity
STH_RS08385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
STH_RS08400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
STH_RS08415	COG3344	reverse transcriptase
STH_RS08425	COG3875	lactate racemase activity
STH_RS08430	COG1304	FMN binding
STH_RS08455	COG1160	GTP binding
STH_RS08460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
STH_RS08465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
STH_RS08480	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
STH_RS08485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
STH_RS08500	COG3069	C4-dicarboxylate transmembrane transporter activity
STH_RS08505	COG2195	Cleaves the N-terminal amino acid of tripeptides
STH_RS08515	COG1294	oxidase, subunit
STH_RS08520	COG1271	oxidase subunit
STH_RS08530	COG0105	UTP biosynthetic process
STH_RS08535	COG4942	peptidase
STH_RS08540	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
STH_RS08545	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
STH_RS08555	COG5002	protein histidine kinase activity
STH_RS08555	COG5001	Diguanylate cyclase
STH_RS08575	COG0402	S-adenosylhomocysteine deaminase activity
STH_RS08580	COG1131	(ABC) transporter
STH_RS08595	COG0667	Aldo Keto reductase
STH_RS08610	COG3679	Belongs to the UPF0342 family
STH_RS08615	COG2045	Belongs to the ComB family
STH_RS08625	COG1199	ATP-dependent helicase activity
STH_RS08625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
STH_RS08630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
STH_RS08635	COG0688	phosphatidylethanolamine metabolic process
STH_RS08710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
STH_RS08715	COG1333	cytochrome c biogenesis protein
STH_RS08720	COG0785	Cytochrome C biogenesis protein
STH_RS08725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH_RS08740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
STH_RS08750	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
STH_RS08765	COG1595	DNA-templated transcription, initiation
STH_RS08775	COG1131	(ABC) transporter
STH_RS08785	COG0464	growth
STH_RS08790	COG1923	regulation of RNA biosynthetic process
STH_RS08795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
STH_RS08800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
STH_RS08840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
STH_RS08850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STH_RS08860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
STH_RS08860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
STH_RS08880	COG0724	RNA recognition motif
STH_RS08890	COG0583	DNA-binding transcription factor activity
STH_RS08905	COG0714	Associated with various cellular activities
STH_RS08920	COG0613	PHP domain protein
STH_RS08925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
STH_RS08935	COG2359	stage V sporulation protein S
STH_RS08940	COG1692	metallophosphoesterase
STH_RS08950	COG1418	mRNA catabolic process
STH_RS08965	COG3842	ATPase activity
STH_RS08970	COG1187	pseudouridine synthase activity
STH_RS08985	COG0700	Nucleoside recognition
STH_RS08990	COG2715	membrane protein required for spore maturation
STH_RS09005	COG3858	chitin binding
STH_RS09025	COG3344	reverse transcriptase
STH_RS09045	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
STH_RS09050	COG3874	Sporulation protein YtfJ
STH_RS09065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
STH_RS09070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
STH_RS09075	COG1994	Peptidase M50
STH_RS09080	COG0617	tRNA 3'-terminal CCA addition
STH_RS09080	COG3620	sequence-specific DNA binding
STH_RS09080	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
STH_RS09090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
STH_RS09095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
STH_RS09100	COG0577	efflux transmembrane transporter activity
STH_RS09100	COG1136	(ABC) transporter
STH_RS09110	COG0019	diaminopimelate decarboxylase activity
STH_RS09135	COG1686	Belongs to the peptidase S11 family
STH_RS09140	COG1131	(ABC) transporter
STH_RS09160	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
STH_RS09165	COG4974	Belongs to the 'phage' integrase family
STH_RS09180	COG1379	DNA repair
STH_RS09185	COG0494	nUDIX hydrolase
STH_RS09190	COG3426	butyrate kinase activity
STH_RS09200	COG0280	phosphate acetyltransferase
STH_RS09215	COG3829	transcription factor binding
STH_RS09215	COG3290	protein histidine kinase activity
STH_RS09220	COG0745	RESPONSE REGULATOR receiver
STH_RS09225	COG0750	zinc metalloprotease
STH_RS09230	COG0497	DNA recombination
STH_RS09235	COG1438	arginine binding
STH_RS09240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
STH_RS09255	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
STH_RS09260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
STH_RS09270	COG0142	geranyltranstransferase activity
STH_RS09275	COG1722	exodeoxyribonuclease VII activity
STH_RS09280	COG1570	exodeoxyribonuclease VII activity
STH_RS09285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
STH_RS09290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
STH_RS09295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
STH_RS09310	COG1302	Protein conserved in bacteria
STH_RS09360	COG3854	ATPases associated with a variety of cellular activities
STH_RS09370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
STH_RS09375	COG0006	proline dipeptidase activity
STH_RS09380	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
STH_RS09390	COG0705	Rhomboid family
STH_RS09390	COG0457	Tetratricopeptide repeat
STH_RS09410	COG0156	8-amino-7-oxononanoate synthase activity
STH_RS09415	COG1063	alcohol dehydrogenase
STH_RS09445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
STH_RS09450	COG1121	(ABC) transporter
STH_RS09460	COG0735	belongs to the Fur family
STH_RS09475	COG0587	DNA-directed DNA polymerase activity
STH_RS09500	COG0564	pseudouridine synthase activity
STH_RS09505	COG0517	IMP dehydrogenase activity
STH_RS09515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STH_RS09545	COG3191	aminopeptidase activity
STH_RS09550	COG4684	Psort location CytoplasmicMembrane, score
STH_RS09565	COG2226	methyltransferase
STH_RS09585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
STH_RS09590	COG0732	type I restriction modification DNA specificity domain
STH_RS09595	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
STH_RS09610	COG1228	amidohydrolase
STH_RS09615	COG0402	S-adenosylhomocysteine deaminase activity
STH_RS09630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
STH_RS09635	COG0095	Lipoate-protein ligase
STH_RS09640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STH_RS09645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STH_RS09650	COG0509	glycine decarboxylation via glycine cleavage system
STH_RS09655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
STH_RS09670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
STH_RS09675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
STH_RS09690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
STH_RS09705	COG1492	cobalamin metabolic process
STH_RS09710	COG1120	ATPase activity
STH_RS09715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STH_RS09725	COG4821	SIS domain
STH_RS09775	COG0473	3-isopropylmalate dehydrogenase activity
STH_RS09780	COG2313	pseudouridylate synthase activity
STH_RS09785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
STH_RS09790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
STH_RS09795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
STH_RS09805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
STH_RS09810	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
STH_RS09820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS09825	COG0601	transmembrane transport
STH_RS09845	COG1131	(ABC) transporter
STH_RS09880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
STH_RS09885	COG1116	anion transmembrane transporter activity
STH_RS09890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
STH_RS09895	COG1674	ftsk spoiiie
STH_RS09905	COG1132	(ABC) transporter
STH_RS09915	COG0330	HflC and HflK could
STH_RS09925	COG1573	uracil-dna glycosylase
STH_RS09940	COG3858	chitin binding
STH_RS09940	COG1388	LysM domain
STH_RS09945	COG1482	cell wall glycoprotein biosynthetic process
STH_RS09950	COG0247	lactate metabolic process
STH_RS09960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
STH_RS09970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STH_RS10000	COG0768	penicillin binding
STH_RS10005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
STH_RS10010	COG3906	Belongs to the UPF0473 family
STH_RS10015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
STH_RS10025	COG3620	sequence-specific DNA binding
STH_RS10025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
STH_RS10025	COG0617	tRNA 3'-terminal CCA addition
STH_RS10035	COG4472	Bacterial protein of unknown function (DUF965)
STH_RS10045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
STH_RS10055	COG1191	sigma factor activity
STH_RS10075	COG5002	protein histidine kinase activity
STH_RS10080	COG0745	RESPONSE REGULATOR receiver
STH_RS10105	COG2814	Major facilitator Superfamily
STH_RS10115	COG3344	reverse transcriptase
STH_RS10160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
STH_RS10175	COG2816	NAD+ diphosphatase activity
STH_RS10190	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
STH_RS10195	COG2949	membrane
STH_RS10215	COG0396	ATPase activity
STH_RS10220	COG0719	Fe-S assembly protein
STH_RS10225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
STH_RS10230	COG0822	iron-sulfur transferase activity
STH_RS10235	COG0719	Fe-S assembly protein
STH_RS10240	COG2146	nitrite reductase [NAD(P)H] activity
STH_RS10245	COG2151	metal-sulfur cluster biosynthetic enzyme
STH_RS10260	COG1595	DNA-templated transcription, initiation
STH_RS10320	COG0437	4 iron, 4 sulfur cluster binding
STH_RS10325	COG0243	molybdopterin cofactor binding
STH_RS10330	COG3344	reverse transcriptase
STH_RS10350	COG4810	utilization protein
STH_RS10360	COG4303	Ethanolamine ammonia lyase large subunit
STH_RS10375	COG0477	Major facilitator Superfamily
STH_RS10380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
STH_RS10400	COG3708	Transcriptional regulator
STH_RS10400	COG2207	Transcriptional regulator
STH_RS10410	COG1131	(ABC) transporter
STH_RS10415	COG1695	Transcriptional regulator
STH_RS10420	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
STH_RS10475	COG5002	protein histidine kinase activity
STH_RS10500	COG0109	protoheme IX farnesyltransferase activity
STH_RS10515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
STH_RS10515	COG2010	Cytochrome c
STH_RS10520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
STH_RS10535	COG3336	cytochrome c oxidase
STH_RS10560	COG0531	amino acid
STH_RS10565	COG0697	spore germination
STH_RS10570	COG1668	transmembrane transport
STH_RS10610	COG0066	3-isopropylmalate dehydratase activity
STH_RS10615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
STH_RS10620	COG0583	DNA-binding transcription factor activity
STH_RS10650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
STH_RS10660	COG0657	acetylesterase activity
STH_RS10670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
STH_RS10695	COG0768	penicillin binding
STH_RS10705	COG1739	Uncharacterized protein family UPF0029
STH_RS10725	COG1918	ferrous iron import across plasma membrane
STH_RS10725	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
STH_RS10740	COG2197	response regulator
STH_RS10745	COG0586	Pfam SNARE associated Golgi protein
STH_RS10780	COG0640	Transcriptional regulator
STH_RS10785	COG0494	nUDIX hydrolase
STH_RS10800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
STH_RS10820	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
STH_RS10825	COG1122	ATPase activity
STH_RS10830	COG1122	ATPase activity
STH_RS10835	COG0508	dehydrogenase complex catalyzes the overall conversion of
STH_RS10840	COG0022	dehydrogenase e1 component
STH_RS10845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
STH_RS10850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STH_RS10855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
STH_RS10865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
STH_RS10885	COG0569	domain protein
STH_RS10885	COG2985	domain, Protein
STH_RS10890	COG1074	ATP-dependent DNA helicase activity
STH_RS10895	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
STH_RS10905	COG0420	3'-5' exonuclease activity
STH_RS10915	COG1653	transport
STH_RS10930	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
STH_RS10935	COG0789	Transcriptional regulator
STH_RS10940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
STH_RS10950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH_RS10960	COG1309	transcriptional regulator
STH_RS10965	COG0318	PFAM AMP-dependent synthetase and ligase
STH_RS10970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STH_RS10990	COG0559	Belongs to the binding-protein-dependent transport system permease family
STH_RS11000	COG3693	PFAM glycoside hydrolase, family 10
STH_RS11005	COG1752	Esterase of the alpha-beta hydrolase superfamily
STH_RS11045	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
STH_RS11045	COG3608	succinylglutamate desuccinylase aspartoacylase
STH_RS11055	COG2814	Major facilitator Superfamily
STH_RS11120	COG2391	methyltransferase activity
STH_RS11175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
STH_RS11200	COG3328	transposase activity
STH_RS11225	COG1131	(ABC) transporter
STH_RS11285	COG3328	transposase activity
STH_RS11300	COG3409	Peptidoglycan-binding domain 1 protein
STH_RS11300	COG3267	Type II secretory pathway component ExeA
STH_RS11370	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
STH_RS11395	COG1484	DNA-dependent DNA replication
STH_RS11405	COG3328	transposase activity
STH_RS11425	COG1205	dead DEAH box helicase
STH_RS11425	COG1111	helicase
STH_RS11430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
STH_RS11445	COG2391	methyltransferase activity
STH_RS11450	COG1349	DNA-binding transcription factor activity
STH_RS11455	COG3395	kinase activity
STH_RS11460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
STH_RS11465	COG2610	gluconate transmembrane transporter activity
STH_RS11475	COG1028	Short-chain dehydrogenase reductase Sdr
STH_RS11485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
STH_RS11500	COG3037	sugar-specific permease SgaT UlaA
STH_RS11510	COG3958	Transketolase
STH_RS11515	COG3959	Transketolase, thiamine diphosphate binding domain
STH_RS11520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH_RS11520	COG3711	transcriptional antiterminator
STH_RS11525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS11530	COG0601	transmembrane transport
STH_RS11535	COG0747	negative chemotaxis
STH_RS11570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STH_RS11575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
STH_RS11590	COG1234	tRNA 3'-trailer cleavage
STH_RS11595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
STH_RS11625	COG0243	molybdopterin cofactor binding
STH_RS11650	COG0698	ribose 5-phosphate isomerase
STH_RS11660	COG1940	carbohydrate kinase activity
STH_RS11665	COG1172	Belongs to the binding-protein-dependent transport system permease family
STH_RS11670	COG1129	ABC transporter
STH_RS11675	COG1879	ABC-type sugar transport system periplasmic component
STH_RS11680	COG1609	Transcriptional regulator
STH_RS11685	COG0473	3-isopropylmalate dehydrogenase activity
STH_RS11705	COG2188	Transcriptional regulator
STH_RS11710	COG1605	Chorismate mutase
STH_RS11710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
STH_RS11715	COG0726	polysaccharide deacetylase
STH_RS11715	COG1649	PFAM Uncharacterised BCR, COG1649
STH_RS11725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
STH_RS11735	COG2197	response regulator
STH_RS11745	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
STH_RS11755	COG1960	acyl-CoA dehydrogenase activity
STH_RS11780	COG0626	cystathionine gamma-synthase activity
STH_RS11785	COG0626	cystathionine gamma-synthase activity
STH_RS11800	COG1051	belongs to the nudix hydrolase family
STH_RS11805	COG0546	phosphoglycolate phosphatase activity
STH_RS11815	COG2226	methyltransferase
STH_RS11820	COG0640	Transcriptional regulator
STH_RS11840	COG1686	Belongs to the peptidase S11 family
STH_RS11890	COG0628	permease
STH_RS11910	COG0482	sulfurtransferase activity
STH_RS11920	COG1959	2 iron, 2 sulfur cluster binding
STH_RS11925	COG0768	penicillin binding
STH_RS11935	COG0589	response to stress
STH_RS11955	COG5002	protein histidine kinase activity
STH_RS11975	COG0116	Belongs to the methyltransferase superfamily
STH_RS12025	COG1819	glycosyl
STH_RS12030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
STH_RS12040	COG0456	acetyltransferase
STH_RS12045	COG0456	acetyltransferase
STH_RS12050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
STH_RS12055	COG0124	histidyl-tRNA synthetase
STH_RS12060	COG3340	Belongs to the peptidase S51 family
STH_RS12065	COG1597	lipid kinase activity
STH_RS12070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
STH_RS12080	COG1846	Transcriptional regulator
STH_RS12085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STH_RS12095	COG1490	D-aminoacyl-tRNA deacylase activity
STH_RS12120	COG1164	Oligoendopeptidase f
STH_RS12130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
STH_RS12135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
STH_RS12140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
STH_RS12140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
STH_RS12155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
STH_RS12160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
STH_RS12185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
STH_RS12185	COG1263	PTS System
STH_RS12195	COG1486	melibiose metabolic process
STH_RS12205	COG0697	spore germination
STH_RS12220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
STH_RS12225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STH_RS12230	COG0584	glycerophosphoryl diester phosphodiesterase
STH_RS12235	COG0583	DNA-binding transcription factor activity
STH_RS12240	COG0494	nUDIX hydrolase
STH_RS12250	COG1960	acyl-CoA dehydrogenase activity
STH_RS12260	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH_RS12260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH_RS12265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH_RS12265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STH_RS12330	COG1960	acyl-CoA dehydrogenase activity
STH_RS12335	COG0704	Plays a role in the regulation of phosphate uptake
STH_RS12350	COG2151	metal-sulfur cluster biosynthetic enzyme
STH_RS12365	COG3396	Phenylacetate-CoA oxygenase
STH_RS12380	COG2610	gluconate transmembrane transporter activity
STH_RS12385	COG1929	Belongs to the glycerate kinase type-1 family
STH_RS12390	COG3835	regulator
STH_RS12410	COG1968	undecaprenyl-diphosphatase activity
STH_RS12425	COG1472	Belongs to the glycosyl hydrolase 3 family
STH_RS12435	COG0646	methionine synthase
STH_RS12435	COG1410	methionine synthase
STH_RS12445	COG0646	methionine synthase
STH_RS12445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
STH_RS12450	COG0739	heme binding
STH_RS12475	COG0667	Aldo Keto reductase
STH_RS12500	COG0492	ferredoxin-NADP+ reductase activity
STH_RS12510	COG2226	methyltransferase
STH_RS12515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
STH_RS12545	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
STH_RS12565	COG4869	propanediol catabolic process
STH_RS12595	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
STH_RS12600	COG0045	succinate-CoA ligase (ADP-forming) activity
STH_RS12605	COG0281	malic enzyme
STH_RS12625	COG1414	Transcriptional regulator
STH_RS12630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
STH_RS12635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
STH_RS12640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH_RS12650	COG0039	L-malate dehydrogenase activity
STH_RS12655	COG0538	isocitrate dehydrogenase activity
STH_RS12685	COG1937	Protein conserved in bacteria
STH_RS12690	COG4347	Protein of unknown function (DUF1405)
STH_RS12695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH_RS12700	COG0714	Associated with various cellular activities
STH_RS12710	COG1305	Transglutaminase-like
STH_RS12715	COG0083	homoserine kinase activity
STH_RS12720	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
STH_RS12725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
STH_RS12730	COG3344	reverse transcriptase
STH_RS12745	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
STH_RS12805	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
STH_RS12810	COG0024	Methionine aminopeptidase
STH_RS12820	COG1132	(ABC) transporter
STH_RS12860	COG1250	3-hydroxyacyl-CoA dehydrogenase
STH_RS12865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
STH_RS12875	COG1686	Belongs to the peptidase S11 family
STH_RS12885	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
STH_RS12895	COG1921	L-seryl-tRNASec selenium transferase activity
STH_RS12905	COG3409	Peptidoglycan-binding domain 1 protein
STH_RS12905	COG5632	N-Acetylmuramoyl-L-alanine amidase
STH_RS12915	COG2223	nitrite transmembrane transporter activity
STH_RS12925	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
STH_RS12935	COG5557	Pfam Polysulphide reductase, NrfD
STH_RS12940	COG0437	4 iron, 4 sulfur cluster binding
STH_RS12940	COG3064	Membrane
STH_RS12950	COG0243	molybdopterin cofactor binding
STH_RS12950	COG3383	formate dehydrogenase (NAD+) activity
STH_RS12960	COG0583	DNA-binding transcription factor activity
STH_RS12965	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
STH_RS12985	COG4152	abc transporter atp-binding protein
STH_RS12995	COG0488	(ABC) transporter
STH_RS13020	COG2217	Heavy metal translocating P-type atpase
STH_RS13030	COG1612	heme a metabolic process
STH_RS13040	COG1126	abc transporter atp-binding protein
STH_RS13045	COG0765	amino acid transport
STH_RS13050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
STH_RS13055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
STH_RS13060	COG0668	transmembrane transport
STH_RS13065	COG1732	Glycine betaine
STH_RS13070	COG1174	glycine betaine transport
STH_RS13080	COG1125	glycine betaine transport
STH_RS13080	COG0517	IMP dehydrogenase activity
STH_RS13090	COG0577	efflux transmembrane transporter activity
STH_RS13090	COG0577	efflux transmembrane transporter activity
STH_RS13095	COG1136	(ABC) transporter
STH_RS13100	COG4585	Histidine kinase
STH_RS13105	COG2197	response regulator
STH_RS13110	COG0471	metal ion transport
STH_RS13115	COG2009	succinate dehydrogenase
STH_RS13120	COG2009	succinate dehydrogenase
STH_RS13130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
STH_RS13145	COG1809	phosphosulfolactate synthase activity
STH_RS13165	COG2814	Major facilitator Superfamily
STH_RS13170	COG2707	UPF0756 membrane protein
STH_RS13185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
STH_RS13195	COG0601	transmembrane transport
STH_RS13200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS13210	COG1028	Short-chain dehydrogenase reductase Sdr
STH_RS13215	COG0519	Catalyzes the synthesis of GMP from XMP
STH_RS13225	COG0010	Belongs to the arginase family
STH_RS13230	COG2843	Capsule synthesis protein
STH_RS13240	COG4555	ABC transporter
STH_RS13255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
STH_RS13260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
STH_RS13270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
STH_RS13295	COG1363	Peptidase, m42
STH_RS13315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
STH_RS13315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
STH_RS13320	COG1832	CoA-binding protein
STH_RS13325	COG2873	o-acetylhomoserine
STH_RS13330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STH_RS13340	COG0028	Belongs to the TPP enzyme family
STH_RS13345	COG0129	dihydroxy-acid dehydratase activity
STH_RS13350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
STH_RS13355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STH_RS13360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
STH_RS13380	COG0077	Prephenate dehydratase
STH_RS13380	COG1605	Chorismate mutase
STH_RS13385	COG1846	Transcriptional regulator
STH_RS13405	COG0673	inositol 2-dehydrogenase activity
STH_RS13410	COG1484	DNA-dependent DNA replication
STH_RS13420	COG4584	PFAM Integrase catalytic
STH_RS13425	COG1484	DNA-dependent DNA replication
STH_RS13445	COG0438	transferase activity, transferring glycosyl groups
STH_RS13450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
STH_RS13465	COG3409	Peptidoglycan-binding domain 1 protein
STH_RS13465	COG3267	Type II secretory pathway component ExeA
STH_RS13480	COG1132	(ABC) transporter
STH_RS13485	COG1132	(ABC) transporter
STH_RS13495	COG3344	reverse transcriptase
STH_RS13505	COG2197	response regulator
STH_RS13510	COG4585	Histidine kinase
STH_RS13520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
STH_RS13525	COG3344	reverse transcriptase
STH_RS13535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
STH_RS13550	COG0584	glycerophosphoryl diester phosphodiesterase
STH_RS13555	COG1279	arginine transmembrane transporter activity
STH_RS13560	COG0460	homoserine dehydrogenase
STH_RS13565	COG1199	ATP-dependent helicase activity
STH_RS13570	COG1012	belongs to the aldehyde dehydrogenase family
STH_RS13660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STH_RS13665	COG0601	transmembrane transport
STH_RS13690	COG0165	Argininosuccinate lyase
STH_RS13695	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
STH_RS13700	COG3842	ATPase activity
STH_RS13705	COG1940	carbohydrate kinase activity
STH_RS13710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
STH_RS13740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
STH_RS13745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
STH_RS13765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
STH_RS13770	COG1007	ATP synthesis coupled electron transport
STH_RS13780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
STH_RS13785	COG0713	ATP synthesis coupled electron transport
STH_RS13800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
STH_RS13805	COG0649	NAD binding
STH_RS13810	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH_RS13815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH_RS13820	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH_RS13855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
STH_RS13860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
STH_RS13875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
STH_RS13885	COG0616	signal peptide processing
STH_RS13900	COG1595	DNA-templated transcription, initiation
STH_RS13910	COG2267	carboxylic ester hydrolase activity
STH_RS13915	COG2211	Major facilitator Superfamily
STH_RS13950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
STH_RS13960	COG0662	Cupin 2, conserved barrel domain protein
STH_RS13965	COG1619	proteins homologs of microcin C7 resistance protein MccF
STH_RS13975	COG2226	methyltransferase
STH_RS13985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
STH_RS14010	COG1215	transferase activity, transferring glycosyl groups
STH_RS14015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
STH_RS14020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
STH_RS14025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STH_RS14030	COG0154	amidase activity
STH_RS14035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STH_RS14040	COG4608	Belongs to the ABC transporter superfamily
STH_RS14045	COG0444	Belongs to the ABC transporter superfamily
STH_RS14050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
STH_RS14085	COG2373	Large extracellular alpha-helical protein
STH_RS14090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
STH_RS14095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
STH_RS14095	COG0140	phosphoribosyl-ATP diphosphatase activity
STH_RS14100	COG0107	imidazoleglycerol-phosphate synthase activity
STH_RS14105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
STH_RS14110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
STH_RS14115	COG0131	Imidazoleglycerol-phosphate dehydratase
STH_RS14120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
STH_RS14125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
STH_RS14130	COG0124	histidyl-tRNA synthetase
STH_RS14135	COG0724	RNA recognition motif
STH_RS14140	COG0475	glutathione-regulated potassium exporter activity
STH_RS14140	COG0569	domain protein
STH_RS14145	COG3033	Beta-eliminating lyase
STH_RS14155	COG4496	protein, YerC YecD
STH_RS14170	COG2267	carboxylic ester hydrolase activity
STH_RS14175	COG5001	Diguanylate cyclase
STH_RS14175	COG5002	protein histidine kinase activity
STH_RS14180	COG0151	Belongs to the GarS family
STH_RS14185	COG0138	bifunctional purine biosynthesis protein purh
STH_RS14195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
STH_RS14200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
STH_RS14205	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
STH_RS14210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
STH_RS14215	COG0047	phosphoribosylformylglycinamidine synthase activity
STH_RS14220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
STH_RS14230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
STH_RS14235	COG2252	PERMEase
STH_RS14240	COG0351	phosphomethylpyrimidine kinase
STH_RS14260	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
STH_RS14265	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
STH_RS14280	COG3118	belongs to the thioredoxin family
STH_RS14295	COG0137	argininosuccinate synthase activity
STH_RS14300	COG2217	Heavy metal translocating P-type atpase
STH_RS14320	COG2268	Band 7 protein
STH_RS14330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
STH_RS14335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
STH_RS14350	COG3284	Transcriptional regulator
STH_RS14355	COG2414	aldehyde ferredoxin oxidoreductase
STH_RS14370	COG3706	GGDEF domain
STH_RS14375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
STH_RS14380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
STH_RS14385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
STH_RS14405	COG1011	Hydrolase
STH_RS14410	COG0459	protein refolding
STH_RS14415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
STH_RS14420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
STH_RS14420	COG1796	DNA polymerase
STH_RS14440	COG0315	cyclic pyranopterin monophosphate synthase activity
STH_RS14445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
STH_RS14455	COG0303	'Molybdopterin
STH_RS14460	COG3949	Membrane
STH_RS14480	COG3226	Transcriptional regulator
STH_RS14485	COG1250	3-hydroxyacyl-CoA dehydrogenase
STH_RS14490	COG0183	Belongs to the thiolase family
STH_RS14495	COG0772	Belongs to the SEDS family
STH_RS14500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
STH_RS14505	COG0516	GMP reductase activity
STH_RS14505	COG0517	IMP dehydrogenase activity
STH_RS14510	COG1573	uracil-dna glycosylase
STH_RS14515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
STH_RS14520	COG0671	phosphoesterase, PA-phosphatase related
STH_RS14525	COG0110	maltose O-acetyltransferase activity
STH_RS14530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
STH_RS14535	COG0328	RNA-DNA hybrid ribonuclease activity
STH_RS14540	COG0456	acetyltransferase
STH_RS14545	COG3344	reverse transcriptase
STH_RS14555	COG0802	atpase or kinase
STH_RS14565	COG2183	response to ionizing radiation
STH_RS14590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
STH_RS14595	COG2337	Toxic component of a toxin-antitoxin (TA) module
STH_RS14605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
STH_RS14610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
STH_RS14610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
STH_RS14615	COG0736	holo-[acyl-carrier-protein] synthase activity
STH_RS14640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
STH_RS14645	COG2151	metal-sulfur cluster biosynthetic enzyme
STH_RS14665	COG0012	GTP binding
STH_RS14680	COG0179	Fumarylacetoacetate (FAA) hydrolase
STH_RS14690	COG3344	reverse transcriptase
STH_RS14705	COG3859	Proton-coupled thiamine transporter YuaJ
STH_RS14715	COG2959	enzyme of heme biosynthesis
STH_RS14725	COG1595	DNA-templated transcription, initiation
STH_RS14735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
STH_RS14740	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
STH_RS14745	COG0840	transmembrane signaling receptor activity
STH_RS14755	COG0210	DNA helicase
STH_RS14775	COG1360	Flagellar Motor Protein
STH_RS14780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
STH_RS14785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
STH_RS14795	COG1516	flagellar protein fliS
STH_RS14805	COG1334	flagellar protein FlaG
STH_RS14815	COG4786	Flagellar basal body rod
STH_RS14815	COG1256	bacterial-type flagellum assembly
STH_RS14835	COG1191	sigma factor activity
STH_RS14845	COG1419	protein localization to endoplasmic reticulum
STH_RS14845	COG1419	protein localization to endoplasmic reticulum
STH_RS14850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
STH_RS14855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
STH_RS14865	COG1987	bacterial-type flagellum assembly
STH_RS14870	COG1338	Plays a role in the flagellum-specific transport system
STH_RS14895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
STH_RS14915	COG1157	protein secretion by the type III secretion system
STH_RS14925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
STH_RS14930	COG1766	The M ring may be actively involved in energy transduction
STH_RS14935	COG1677	Flagellar hook-basal body complex protein FliE
STH_RS14945	COG1815	bacterial-type flagellum-dependent cell motility
STH_RS14950	COG4786	Flagellar basal body rod
STH_RS14965	COG1960	acyl-CoA dehydrogenase activity
STH_RS14970	COG0183	Belongs to the thiolase family
STH_RS14975	COG1024	Enoyl-CoA hydratase
STH_RS14975	COG1250	3-hydroxyacyl-CoA dehydrogenase
STH_RS14980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
STH_RS14985	COG2086	electron transfer activity
STH_RS14990	COG1309	transcriptional regulator
STH_RS14995	COG0318	PFAM AMP-dependent synthetase and ligase
STH_RS15005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
STH_RS15020	COG4120	Belongs to the binding-protein-dependent transport system permease family
STH_RS15025	COG1116	anion transmembrane transporter activity
STH_RS15085	COG0473	3-isopropylmalate dehydrogenase activity
STH_RS15105	COG0860	N-Acetylmuramoyl-L-alanine amidase
STH_RS15110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
STH_RS15115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
STH_RS15120	COG0101	tRNA pseudouridine synthase activity
STH_RS15125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
STH_RS15130	COG1122	ATPase activity
STH_RS15135	COG1122	ATPase activity
STH_RS15140	COG0203	ribosomal protein L17
STH_RS15145	COG0202	RNA polymerase activity
STH_RS15150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
STH_RS15155	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
STH_RS15160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
STH_RS15165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
STH_RS15170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
STH_RS15180	COG0563	adenylate kinase activity
STH_RS15185	COG0201	protein transport
STH_RS15190	COG0200	Binds to the 23S rRNA
STH_RS15195	COG1841	ribosomal large subunit assembly
STH_RS15200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
STH_RS15205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
STH_RS15210	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
STH_RS15215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
STH_RS15220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
STH_RS15225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
STH_RS15230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
STH_RS15235	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
STH_RS15240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
STH_RS15245	COG0255	Belongs to the universal ribosomal protein uL29 family
STH_RS15250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
STH_RS15255	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
STH_RS15260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
STH_RS15265	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
STH_RS15270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
STH_RS15275	COG0089	rRNA binding
STH_RS15280	COG0088	Forms part of the polypeptide exit tunnel
STH_RS15285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
STH_RS15290	COG0051	transcription antitermination factor activity, RNA binding
STH_RS15295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
STH_RS15300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
STH_RS15305	COG0049	tRNA binding
STH_RS15310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
STH_RS15315	COG1358	cellular component organization or biogenesis
STH_RS15320	COG2813	Specifically methylates the guanine in position
STH_RS15325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
STH_RS15330	COG0085	RNA polymerase activity
STH_RS15335	COG0222	ribosome binding
STH_RS15340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
STH_RS15345	COG0081	regulation of translation
STH_RS15350	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
STH_RS15355	COG0250	Participates in transcription elongation, termination and antitermination
STH_RS15360	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
STH_RS15375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
STH_RS15390	COG4585	Histidine kinase
STH_RS15405	COG3383	formate dehydrogenase (NAD+) activity
STH_RS15405	COG0243	molybdopterin cofactor binding
STH_RS15410	COG0437	4 iron, 4 sulfur cluster binding
STH_RS15425	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
STH_RS15455	COG3344	reverse transcriptase
STH_RS15460	COG0456	acetyltransferase
STH_RS15475	COG2720	vancomycin resistance protein
STH_RS15480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
STH_RS15485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
STH_RS15490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
STH_RS15495	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
STH_RS15500	COG0215	cysteine-tRNA ligase activity
STH_RS15505	COG1045	serine acetyltransferase
STH_RS15510	COG3344	reverse transcriptase
STH_RS15515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
STH_RS15520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
STH_RS15525	COG4956	integral membrane protein (PIN domain superfamily)
STH_RS15530	COG1329	Transcriptional regulator
STH_RS15545	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
STH_RS15550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
STH_RS15555	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
STH_RS15565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
STH_RS15575	COG0542	response to heat
STH_RS15580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
STH_RS15585	COG3880	PFAM UvrB UvrC protein
STH_RS15610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
STH_RS15615	COG0546	phosphoglycolate phosphatase activity
STH_RS15620	COG2878	Part of a membrane complex involved in electron transport
STH_RS15665	COG3278	Belongs to the heme-copper respiratory oxidase family
STH_RS15690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
STH_RS15695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
STH_RS15705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
STH_RS15710	COG1307	EDD domain protein, DegV family
STH_RS15715	COG2197	response regulator
STH_RS15725	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
STH_RS15740	COG0405	Gamma-glutamyltransferase
STH_RS15745	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
STH_RS15745	COG1013	pyruvate-flavodoxin oxidoreductase activity
STH_RS15745	COG0674	pyruvate-flavodoxin oxidoreductase activity
STH_RS15745	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
STH_RS15760	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
STH_RS15765	COG0724	RNA recognition motif
STH_RS15770	COG0772	Belongs to the SEDS family
STH_RS15780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
STH_RS15785	COG1053	succinate dehydrogenase
STH_RS15790	COG2009	succinate dehydrogenase
STH_RS15800	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
STH_RS15810	COG0314	molybdopterin synthase activity
STH_RS15825	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
STH_RS15830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
STH_RS15835	COG0157	Belongs to the NadC ModD family
STH_RS15840	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
STH_RS15845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
STH_RS15850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
STH_RS15855	COG2759	Belongs to the formate--tetrahydrofolate ligase family
STH_RS15865	COG1228	amidohydrolase
STH_RS15875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
STH_RS15880	COG2986	histidine ammonia-lyase
STH_RS15885	COG0612	Peptidase, M16
STH_RS15890	COG0612	Peptidase, M16
STH_RS15900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STH_RS15905	COG0037	tRNA processing
STH_RS15920	COG0303	'Molybdopterin
STH_RS15925	COG1763	Mo-molybdopterin cofactor biosynthetic process
STH_RS15970	COG0577	efflux transmembrane transporter activity
STH_RS15975	COG1136	(ABC) transporter
STH_RS15980	COG5002	protein histidine kinase activity
STH_RS15985	COG0745	RESPONSE REGULATOR receiver
STH_RS15990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
STH_RS16000	COG3842	ATPase activity
STH_RS16010	COG1840	ABC-type Fe3 transport system, periplasmic component
STH_RS16015	COG2197	response regulator
STH_RS16060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
STH_RS16070	COG3956	TIGRFAM MazG family protein
STH_RS16080	COG2244	polysaccharide biosynthetic process
STH_RS16085	COG2002	toxin-antitoxin pair type II binding
STH_RS16090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
STH_RS16100	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
STH_RS16105	COG0193	aminoacyl-tRNA hydrolase activity
STH_RS16110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
STH_RS16115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
STH_RS16120	COG2088	sporulation resulting in formation of a cellular spore
STH_RS16130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
STH_RS16135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
STH_RS16140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
STH_RS16145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
STH_RS16150	COG4466	Protein conserved in bacteria
STH_RS16155	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
STH_RS16160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
STH_RS16165	COG3584	3D domain protein
STH_RS16165	COG1388	LysM domain
STH_RS16200	COG0084	hydrolase, TatD family'
STH_RS16205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STH_RS16205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STH_RS16210	COG2002	toxin-antitoxin pair type II binding
STH_RS16215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
STH_RS16220	COG1774	PSP1 C-terminal conserved region
STH_RS16230	COG3870	Protein conserved in bacteria
STH_RS16235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
STH_RS16240	COG1982	Orn Lys Arg decarboxylase major
STH_RS16245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
STH_RS16255	COG0674	pyruvate-flavodoxin oxidoreductase activity
STH_RS16265	COG2959	enzyme of heme biosynthesis
STH_RS16270	COG3773	Cell wall hydrolase
STH_RS16270	COG3409	Peptidoglycan-binding domain 1 protein
STH_RS16280	COG1982	Orn Lys Arg decarboxylase major
STH_RS16285	COG2323	membrane
STH_RS16320	COG1132	(ABC) transporter
STH_RS16325	COG1132	(ABC) transporter
STH_RS16335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
STH_RS16360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
STH_RS16380	COG2205	protein histidine kinase activity
STH_RS16385	COG0745	RESPONSE REGULATOR receiver
STH_RS16390	COG3142	Participates in the control of copper homeostasis
STH_RS16395	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
STH_RS16405	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
STH_RS16410	COG3383	formate dehydrogenase (NAD+) activity
STH_RS16415	COG3383	formate dehydrogenase (NAD+) activity
STH_RS16430	COG2204	response regulator
STH_RS16435	COG4191	Histidine kinase
STH_RS16440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
STH_RS16450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
STH_RS16455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
STH_RS16470	COG5002	protein histidine kinase activity
STH_RS16475	COG0745	RESPONSE REGULATOR receiver
STH_RS16500	COG3344	reverse transcriptase
STH_RS16515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
STH_RS16520	COG0305	Participates in initiation and elongation during chromosome replication
STH_RS16525	COG0470	DNA polymerase III
STH_RS16525	COG1067	ATP-dependent peptidase activity
STH_RS16530	COG0359	binds to the 23S rRNA
STH_RS16540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
STH_RS16550	COG0360	Binds together with S18 to 16S ribosomal RNA
STH_RS16595	COG1475	DNA binding
STH_RS16600	COG1192	Involved in chromosome partitioning
STH_RS16605	COG0357	Ribosomal RNA small subunit methyltransferase G
STH_RS16610	COG0445	tRNA wobble uridine modification
STH_RS16615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
STH_RS16620	COG1847	R3H domain protein
STH_RS16625	COG0706	membrane insertase activity
STH_RS16630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
STH_RS16635	COG0594	ribonuclease P activity
STH_RS16640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
STH_RS16650	COG2197	response regulator
STH_RS16665	COG0741	lytic transglycosylase activity
STH_RS16665	COG1196	nuclear chromosome segregation
STH_RS16665	COG0739	heme binding
STH_RS16685	COG1196	nuclear chromosome segregation
STH_RS16685	COG0741	lytic transglycosylase activity
STH_RS16685	COG0739	heme binding
STH_RS16690	COG2816	NAD+ diphosphatase activity
STH_RS16695	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
STH_RS16695	COG0352	thiamine-phosphate diphosphorylase activity
STH_RS16705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STH_RS16750	COG0517	IMP dehydrogenase activity
STH_RS16750	COG1994	Peptidase M50
STH_RS16770	COG3025	triphosphatase activity
STH_RS16775	COG2203	Gaf domain
STH_RS16775	COG4585	Histidine kinase
STH_RS16785	COG2267	carboxylic ester hydrolase activity
STH_RS16800	COG2340	Cysteine-rich secretory protein family
STH_RS16805	COG3706	GGDEF domain
STH_RS16810	COG0601	transmembrane transport
STH_RS16815	COG0601	transmembrane transport
STH_RS16830	COG1028	Short-chain dehydrogenase reductase Sdr
STH_RS16835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STH_RS16855	COG4585	Histidine kinase
STH_RS16885	COG0840	transmembrane signaling receptor activity
STH_RS16890	COG1136	(ABC) transporter
STH_RS16900	COG5001	Diguanylate cyclase
STH_RS16900	COG3300	MHYT domain
STH_RS16920	COG0739	heme binding
STH_RS16920	COG0741	lytic transglycosylase activity
STH_RS16920	COG1196	nuclear chromosome segregation
STH_RS16950	COG1686	Belongs to the peptidase S11 family
STH_RS16955	COG3842	ATPase activity
STH_RS16960	COG2203	Gaf domain
STH_RS16960	COG4585	Histidine kinase
STH_RS16965	COG0860	N-Acetylmuramoyl-L-alanine amidase
STH_RS16985	COG0739	heme binding
STH_RS17010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
STH_RS17015	COG2385	sporulation resulting in formation of a cellular spore
STH_RS17020	COG2197	response regulator
STH_RS17025	COG1846	Transcriptional regulator
STH_RS17045	COG1597	lipid kinase activity
STH_RS17075	COG0501	Belongs to the peptidase M48B family
STH_RS17105	COG3584	3D domain protein
STH_RS17105	COG1388	LysM domain
STH_RS17120	COG0561	phosphatase activity
STH_RS17175	COG2137	regulation of response to DNA damage stimulus
STH_RS17185	COG1183	phosphatidylcholine synthase activity
STH_RS17200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
STH_RS17210	COG3870	Protein conserved in bacteria
STH_RS17215	COG0726	polysaccharide deacetylase
STH_RS17235	COG1316	TRANSCRIPTIONal
STH_RS17240	COG3012	SEC-C Motif Domain Protein
STH_RS17265	COG1132	(ABC) transporter
STH_RS17285	COG0745	RESPONSE REGULATOR receiver
STH_RS17310	COG1999	signal sequence binding
STH_RS17330	COG3706	GGDEF domain
STH_RS17335	COG4585	Histidine kinase
STH_RS17345	COG0419	ATPase involved in DNA repair
STH_RS17350	COG0746	molybdenum cofactor guanylyltransferase activity
STH_RS17390	COG2378	regulation of single-species biofilm formation
STH_RS17395	COG3214	Protein conserved in bacteria
STH_RS17400	COG1309	transcriptional regulator
STH_RS17435	COG0456	acetyltransferase
STH_RS17445	COG2340	Cysteine-rich secretory protein family
STH_RS17465	COG2226	methyltransferase
STH_RS17505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
STH_RS17515	COG3951	Flagellar rod assembly protein muramidase FlgJ
STH_RS17515	COG1705	Flagellar rod assembly protein muramidase FlgJ
STH_RS17530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STH_RS17545	COG0741	lytic transglycosylase activity
STH_RS17560	COG1051	belongs to the nudix hydrolase family
STH_RS17575	COG2226	methyltransferase
STH_RS17580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
STH_RS17590	COG3706	GGDEF domain
STH_RS17600	COG4585	Histidine kinase
STH_RS17605	COG1361	Conserved repeat domain
STH_RS17625	COG1309	transcriptional regulator
STH_RS17650	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
STH_RS17655	COG0739	heme binding