locus-tag	class	description
Mal52_RS00010	COG0592	DNA-directed DNA polymerase activity
Mal52_RS00020	COG0187	DNA topoisomerase II activity
Mal52_RS00025	COG2084	Dehydrogenase
Mal52_RS00030	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_RS00050	COG2815	serine threonine protein kinase
Mal52_RS00050	COG0515	serine threonine protein kinase
Mal52_RS00115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Mal52_RS00120	COG3494	Protein of unknown function (DUF1009)
Mal52_RS00125	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mal52_RS00150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Mal52_RS00170	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_RS00280	COG0598	Magnesium transport protein CorA
Mal52_RS00285	COG0473	3-isopropylmalate dehydrogenase activity
Mal52_RS00290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Mal52_RS00295	COG2890	protein-(glutamine-N5) methyltransferase activity
Mal52_RS00300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Mal52_RS00305	COG0254	rRNA binding
Mal52_RS00325	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS00350	COG0515	serine threonine protein kinase
Mal52_RS00350	COG2815	serine threonine protein kinase
Mal52_RS00355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Mal52_RS00365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_RS00420	COG2204	response regulator
Mal52_RS00435	COG1677	Flagellar hook-basal body complex protein FliE
Mal52_RS00445	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Mal52_RS00455	COG1157	protein secretion by the type III secretion system
Mal52_RS00475	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Mal52_RS00495	COG1360	Flagellar Motor Protein
Mal52_RS00505	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Mal52_RS00505	COG1776	CheC inhibitor of MCP methylation
Mal52_RS00515	COG1338	Plays a role in the flagellum-specific transport system
Mal52_RS00520	COG1987	bacterial-type flagellum assembly
Mal52_RS00525	COG1684	flagellar biosynthetic protein fliR
Mal52_RS00530	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Mal52_RS00545	COG0784	Response regulator, receiver
Mal52_RS00545	COG2205	protein histidine kinase activity
Mal52_RS00545	COG5002	protein histidine kinase activity
Mal52_RS00585	COG1376	ErfK ybiS ycfS ynhG family protein
Mal52_RS00595	COG0673	inositol 2-dehydrogenase activity
Mal52_RS00605	COG1943	Transposase
Mal52_RS00615	COG0714	Associated with various cellular activities
Mal52_RS00665	COG1515	deoxyribonuclease V activity
Mal52_RS00670	COG2200	EAL domain
Mal52_RS00670	COG2199	diguanylate cyclase activity
Mal52_RS00670	COG3287	FIST C domain
Mal52_RS00690	COG2815	serine threonine protein kinase
Mal52_RS00690	COG0515	serine threonine protein kinase
Mal52_RS00705	COG2154	pterin-4-alpha-carbinolamine dehydratase
Mal52_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS00730	COG0517	IMP dehydrogenase activity
Mal52_RS00730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Mal52_RS00730	COG0617	tRNA 3'-terminal CCA addition
Mal52_RS00735	COG0039	L-malate dehydrogenase activity
Mal52_RS00885	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS00895	COG1862	Preprotein translocase
Mal52_RS00900	COG0343	queuine tRNA-ribosyltransferase activity
Mal52_RS00925	COG4536	flavin adenine dinucleotide binding
Mal52_RS00940	COG0142	geranyltranstransferase activity
Mal52_RS00945	COG0315	cyclic pyranopterin monophosphate synthase activity
Mal52_RS00960	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Mal52_RS00965	COG0174	glutamine synthetase
Mal52_RS00975	COG0004	ammonium transporteR
Mal52_RS00985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Mal52_RS00990	COG0616	signal peptide processing
Mal52_RS00995	COG0598	Magnesium transport protein CorA
Mal52_RS01000	COG0189	ligase activity
Mal52_RS01000	COG4067	protein conserved in archaea
Mal52_RS01005	COG0569	domain protein
Mal52_RS01005	COG0189	ligase activity
Mal52_RS01025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Mal52_RS01035	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_RS01040	COG1597	lipid kinase activity
Mal52_RS01045	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Mal52_RS01055	COG3119	arylsulfatase activity
Mal52_RS01115	COG1560	Kdo2-lipid A biosynthetic process
Mal52_RS01145	COG0714	Associated with various cellular activities
Mal52_RS01170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Mal52_RS01175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Mal52_RS01200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Mal52_RS01205	COG0626	cystathionine gamma-synthase activity
Mal52_RS01210	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_RS01215	COG0205	6-phosphofructokinase activity
Mal52_RS01220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_RS01235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Mal52_RS01240	COG0287	Prephenate dehydrogenase
Mal52_RS01245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Mal52_RS01285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Mal52_RS01290	COG2226	methyltransferase
Mal52_RS01305	COG1136	(ABC) transporter
Mal52_RS01305	COG0577	efflux transmembrane transporter activity
Mal52_RS01350	COG3022	response to hydroperoxide
Mal52_RS01365	COG0537	adenosine 5'-monophosphoramidase activity
Mal52_RS01375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mal52_RS01395	COG0058	SHG alpha-glucan phosphorylase activity
Mal52_RS01400	COG0649	NAD binding
Mal52_RS01405	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mal52_RS01410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mal52_RS01425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Mal52_RS01490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Mal52_RS01505	COG0010	Belongs to the arginase family
Mal52_RS01515	COG0028	Belongs to the TPP enzyme family
Mal52_RS01515	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
Mal52_RS01545	COG1459	type II secretion system
Mal52_RS01550	COG1459	type II secretion system
Mal52_RS01560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_RS01565	COG0545	Peptidyl-prolyl cis-trans isomerase
Mal52_RS01590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mal52_RS01605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Mal52_RS01610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Mal52_RS01630	COG1725	Transcriptional regulator
Mal52_RS01635	COG1131	(ABC) transporter
Mal52_RS01675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Mal52_RS01680	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Mal52_RS01690	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Mal52_RS01705	COG0069	glutamate synthase activity
Mal52_RS01705	COG0067	glutamate synthase
Mal52_RS01705	COG0070	glutamate synthase
Mal52_RS01710	COG0493	'glutamate synthase
Mal52_RS01720	COG0129	dihydroxy-acid dehydratase activity
Mal52_RS01730	COG2208	phosphoserine phosphatase activity
Mal52_RS01730	COG2770	Histidine kinase
Mal52_RS01795	COG3206	protein involved in exopolysaccharide biosynthesis
Mal52_RS01795	COG0489	protein tyrosine kinase activity
Mal52_RS01805	COG0726	polysaccharide deacetylase
Mal52_RS01820	COG0438	transferase activity, transferring glycosyl groups
Mal52_RS01835	COG0438	transferase activity, transferring glycosyl groups
Mal52_RS01850	COG0438	transferase activity, transferring glycosyl groups
Mal52_RS01855	COG0367	asparagine synthase
Mal52_RS01860	COG1215	transferase activity, transferring glycosyl groups
Mal52_RS01865	COG1216	Glycosyl transferase, family 2
Mal52_RS01880	COG0463	Glycosyl transferase, family 2
Mal52_RS01885	COG3394	polysaccharide catabolic process
Mal52_RS01920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Mal52_RS01925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Mal52_RS01930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Mal52_RS01950	COG4956	integral membrane protein (PIN domain superfamily)
Mal52_RS01980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mal52_RS01985	COG0187	DNA topoisomerase II activity
Mal52_RS02010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Mal52_RS02025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Mal52_RS02035	COG0750	zinc metalloprotease
Mal52_RS02040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Mal52_RS02070	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_RS02080	COG0788	formyltetrahydrofolate deformylase activity
Mal52_RS02095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mal52_RS02115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Mal52_RS02125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Mal52_RS02130	COG0328	RNA-DNA hybrid ribonuclease activity
Mal52_RS02135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Mal52_RS02145	COG1295	ribonuclease BN
Mal52_RS02185	COG3119	arylsulfatase activity
Mal52_RS02200	COG0515	serine threonine protein kinase
Mal52_RS02200	COG2815	serine threonine protein kinase
Mal52_RS02220	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_RS02235	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Mal52_RS02270	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Mal52_RS02305	COG3119	arylsulfatase activity
Mal52_RS02320	COG0584	glycerophosphoryl diester phosphodiesterase
Mal52_RS02355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Mal52_RS02360	COG2116	formate transmembrane transporter activity
Mal52_RS02365	COG2217	Heavy metal translocating P-type atpase
Mal52_RS02385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mal52_RS02395	COG1846	Transcriptional regulator
Mal52_RS02405	COG3119	arylsulfatase activity
Mal52_RS02425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Mal52_RS02430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Mal52_RS02435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Mal52_RS02440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mal52_RS02475	COG0443	Heat shock 70 kDa protein
Mal52_RS02525	COG5002	protein histidine kinase activity
Mal52_RS02525	COG2198	Histidine kinase
Mal52_RS02525	COG0784	Response regulator, receiver
Mal52_RS02535	COG2234	aminopeptidase activity
Mal52_RS02545	COG1674	ftsk spoiiie
Mal52_RS02565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Mal52_RS02570	COG0581	inorganic phosphate transmembrane transporter activity
Mal52_RS02575	COG0573	inorganic phosphate transmembrane transporter activity
Mal52_RS02580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Mal52_RS02585	COG1283	sodium-dependent phosphate transmembrane transporter activity
Mal52_RS02595	COG0489	protein tyrosine kinase activity
Mal52_RS02600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Mal52_RS02605	COG0159	tryptophan synthase activity
Mal52_RS02610	COG2738	Putative neutral zinc metallopeptidase
Mal52_RS02645	COG2890	protein-(glutamine-N5) methyltransferase activity
Mal52_RS02650	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS02655	COG0673	inositol 2-dehydrogenase activity
Mal52_RS02665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Mal52_RS02680	COG1073	alpha beta
Mal52_RS02685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Mal52_RS02725	COG3119	arylsulfatase activity
Mal52_RS02765	COG1643	Atp-dependent helicase
Mal52_RS02775	COG2414	aldehyde ferredoxin oxidoreductase
Mal52_RS02785	COG1509	lysine 2,3-aminomutase activity
Mal52_RS02790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Mal52_RS02830	COG1940	carbohydrate kinase activity
Mal52_RS02860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mal52_RS02865	COG1132	(ABC) transporter
Mal52_RS02910	COG0482	sulfurtransferase activity
Mal52_RS02920	COG1196	nuclear chromosome segregation
Mal52_RS02930	COG1649	PFAM Uncharacterised BCR, COG1649
Mal52_RS02930	COG0726	polysaccharide deacetylase
Mal52_RS02935	COG2204	response regulator
Mal52_RS02945	COG1007	ATP synthesis coupled electron transport
Mal52_RS02955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Mal52_RS02955	COG2111	Na H antiporter
Mal52_RS03010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Mal52_RS03020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Mal52_RS03035	COG0156	8-amino-7-oxononanoate synthase activity
Mal52_RS03040	COG1063	alcohol dehydrogenase
Mal52_RS03080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mal52_RS03080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mal52_RS03110	COG0284	orotidine-5'-phosphate decarboxylase activity
Mal52_RS03120	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Mal52_RS03125	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Mal52_RS03130	COG2239	Acts as a magnesium transporter
Mal52_RS03145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Mal52_RS03160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Mal52_RS03175	COG0302	gtp cyclohydrolase
Mal52_RS03195	COG1321	iron dependent repressor
Mal52_RS03200	COG0803	Belongs to the bacterial solute-binding protein 9 family
Mal52_RS03205	COG1121	(ABC) transporter
Mal52_RS03210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Mal52_RS03210	COG1321	iron dependent repressor
Mal52_RS03215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Mal52_RS03225	COG0552	protein localization to endoplasmic reticulum
Mal52_RS03260	COG0196	riboflavin kinase activity
Mal52_RS03265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Mal52_RS03275	COG1104	cysteine desulfurase activity
Mal52_RS03290	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Mal52_RS03295	COG1805	sodium ion transport
Mal52_RS03305	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Mal52_RS03310	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Mal52_RS03315	COG2871	sodium ion transport
Mal52_RS03320	COG1477	protein flavinylation
Mal52_RS03325	COG0579	oxidoreductase
Mal52_RS03330	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Mal52_RS03345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Mal52_RS03350	COG1668	transmembrane transport
Mal52_RS03355	COG1131	(ABC) transporter
Mal52_RS03360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Mal52_RS03365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Mal52_RS03390	COG0047	phosphoribosylformylglycinamidine synthase activity
Mal52_RS03415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Mal52_RS03430	COG1530	ribonuclease E activity
Mal52_RS03435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Mal52_RS03480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Mal52_RS03485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Mal52_RS03495	COG0314	molybdopterin synthase activity
Mal52_RS03545	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Mal52_RS03555	COG3119	arylsulfatase activity
Mal52_RS03555	COG3408	Glycogen debranching enzyme
Mal52_RS03560	COG0531	amino acid
Mal52_RS03570	COG0069	glutamate synthase activity
Mal52_RS03600	COG1030	water channel activity
Mal52_RS03605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Mal52_RS03610	COG0594	ribonuclease P activity
Mal52_RS03615	COG1136	(ABC) transporter
Mal52_RS03620	COG1136	(ABC) transporter
Mal52_RS03620	COG0577	efflux transmembrane transporter activity
Mal52_RS03625	COG0484	heat shock protein binding
Mal52_RS03650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Mal52_RS03655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_RS03665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Mal52_RS03670	COG0138	bifunctional purine biosynthesis protein purh
Mal52_RS03680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Mal52_RS03685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_RS03690	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_RS03755	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mal52_RS03770	COG3119	arylsulfatase activity
Mal52_RS03785	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Mal52_RS03795	COG0514	ATP-dependent DNA helicase (RecQ)
Mal52_RS03805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mal52_RS03835	COG2814	Major facilitator Superfamily
Mal52_RS03850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Mal52_RS03890	COG1573	uracil-dna glycosylase
Mal52_RS03930	COG2169	Transcriptional regulator
Mal52_RS03930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Mal52_RS03950	COG0387	Pfam Sodium calcium exchanger
Mal52_RS03960	COG0038	chloride channel
Mal52_RS03965	COG0584	glycerophosphoryl diester phosphodiesterase
Mal52_RS04025	COG2912	Transglutaminase-like superfamily
Mal52_RS04035	COG0740	serine-type endopeptidase activity
Mal52_RS04040	COG0740	serine-type endopeptidase activity
Mal52_RS04045	COG0544	peptidyl-prolyl cis-trans isomerase activity
Mal52_RS04055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Mal52_RS04060	COG0822	iron-sulfur transferase activity
Mal52_RS04075	COG1611	Belongs to the LOG family
Mal52_RS04080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Mal52_RS04115	COG1216	Glycosyl transferase, family 2
Mal52_RS04145	COG0714	Associated with various cellular activities
Mal52_RS04155	COG3177	Filamentation induced by cAMP protein fic
Mal52_RS04185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Mal52_RS04190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Mal52_RS04195	COG0228	four-way junction DNA binding
Mal52_RS04200	COG0336	Belongs to the RNA methyltransferase TrmD family
Mal52_RS04205	COG0335	large ribosomal subunit rRNA binding
Mal52_RS04210	COG0792	nuclease activity
Mal52_RS04220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Mal52_RS04260	COG1690	Belongs to the RtcB family
Mal52_RS04300	COG0583	DNA-binding transcription factor activity
Mal52_RS04330	COG3119	arylsulfatase activity
Mal52_RS04360	COG3119	arylsulfatase activity
Mal52_RS04365	COG3119	arylsulfatase activity
Mal52_RS04375	COG2201	protein-glutamate methylesterase activity
Mal52_RS04415	COG1253	flavin adenine dinucleotide binding
Mal52_RS04455	COG3119	arylsulfatase activity
Mal52_RS04570	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_RS04600	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Mal52_RS04610	COG1199	ATP-dependent helicase activity
Mal52_RS04640	COG1192	Involved in chromosome partitioning
Mal52_RS04660	COG0167	dihydroorotate dehydrogenase activity
Mal52_RS04685	COG0395	ABC-type sugar transport system, permease component
Mal52_RS04715	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Mal52_RS04725	COG1301	dicarboxylic acid transport
Mal52_RS04730	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Mal52_RS04765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Mal52_RS04790	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_RS04800	COG5492	domain, Protein
Mal52_RS04800	COG4932	domain protein
Mal52_RS04820	COG1132	(ABC) transporter
Mal52_RS04825	COG0390	transport system, permease component
Mal52_RS04830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Mal52_RS04855	COG3119	arylsulfatase activity
Mal52_RS04865	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Mal52_RS04880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Mal52_RS04885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Mal52_RS04890	COG1596	polysaccharide export
Mal52_RS04890	COG1555	photosystem II stabilization
Mal52_RS04915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Mal52_RS04935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Mal52_RS04940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Mal52_RS04945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Mal52_RS04955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mal52_RS04960	COG0601	transmembrane transport
Mal52_RS04965	COG0747	negative chemotaxis
Mal52_RS04975	COG0456	acetyltransferase
Mal52_RS04975	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Mal52_RS04985	COG0473	3-isopropylmalate dehydrogenase activity
Mal52_RS05075	COG3119	arylsulfatase activity
Mal52_RS05115	COG0488	(ABC) transporter
Mal52_RS05150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Mal52_RS05155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Mal52_RS05160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mal52_RS05165	COG0405	Gamma-glutamyltransferase
Mal52_RS05175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mal52_RS05210	COG1570	exodeoxyribonuclease VII activity
Mal52_RS05230	COG0714	Associated with various cellular activities
Mal52_RS05245	COG1174	glycine betaine transport
Mal52_RS05250	COG1125	glycine betaine transport
Mal52_RS05250	COG0517	IMP dehydrogenase activity
Mal52_RS05255	COG0513	Belongs to the DEAD box helicase family
Mal52_RS05345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mal52_RS05375	COG3118	belongs to the thioredoxin family
Mal52_RS05380	COG0483	inositol monophosphate 1-phosphatase activity
Mal52_RS05385	COG0175	sulfate reduction
Mal52_RS05390	COG0515	serine threonine protein kinase
Mal52_RS05390	COG2815	serine threonine protein kinase
Mal52_RS05400	COG0793	Belongs to the peptidase S41A family
Mal52_RS05405	COG1454	alcohol dehydrogenase
Mal52_RS05455	COG0330	HflC and HflK could
Mal52_RS05460	COG0330	HflC and HflK could
Mal52_RS05465	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Mal52_RS05470	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Mal52_RS05475	COG4555	ABC transporter
Mal52_RS05480	COG1668	transmembrane transport
Mal52_RS05505	COG3842	ATPase activity
Mal52_RS05545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Mal52_RS05570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_RS05580	COG1175	transmembrane transport
Mal52_RS05600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Mal52_RS05610	COG1774	PSP1 C-terminal conserved region
Mal52_RS05660	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Mal52_RS05665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_RS05675	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Mal52_RS05690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mal52_RS05695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mal52_RS05750	COG0714	Associated with various cellular activities
Mal52_RS05780	COG3258	Cytochrome c
Mal52_RS05795	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mal52_RS05800	COG2427	Protein of unknown function (DUF1641)
Mal52_RS05805	COG0450	alkyl hydroperoxide reductase
Mal52_RS05860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Mal52_RS05870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Mal52_RS05880	COG1045	serine acetyltransferase
Mal52_RS05885	COG0463	Glycosyl transferase, family 2
Mal52_RS05935	COG0297	glycogen (starch) synthase activity
Mal52_RS05940	COG1215	transferase activity, transferring glycosyl groups
Mal52_RS06015	COG0745	RESPONSE REGULATOR receiver
Mal52_RS06035	COG0673	inositol 2-dehydrogenase activity
Mal52_RS06040	COG0714	Associated with various cellular activities
Mal52_RS06070	COG0436	Aminotransferase
Mal52_RS06085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Mal52_RS06090	COG0166	Belongs to the GPI family
Mal52_RS06095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Mal52_RS06100	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mal52_RS06110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mal52_RS06120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_RS06160	COG0702	epimerase
Mal52_RS06200	COG1253	flavin adenine dinucleotide binding
Mal52_RS06220	COG1331	Highly conserved protein containing a thioredoxin domain
Mal52_RS06235	COG0723	plastoquinol--plastocyanin reductase activity
Mal52_RS06235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mal52_RS06275	COG1796	DNA polymerase
Mal52_RS06275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Mal52_RS06280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mal52_RS06285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Mal52_RS06325	COG0644	oxidoreductase
Mal52_RS06390	COG0358	DNA primase activity
Mal52_RS06475	COG4974	Belongs to the 'phage' integrase family
Mal52_RS06530	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Mal52_RS06650	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Mal52_RS06675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mal52_RS06680	COG2267	carboxylic ester hydrolase activity
Mal52_RS06685	COG0800	Aldolase
Mal52_RS06690	COG0784	Response regulator, receiver
Mal52_RS06695	COG4251	negative regulation of phosphorylation
Mal52_RS06700	COG1285	pathogenesis
Mal52_RS06725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Mal52_RS06760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Mal52_RS06785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_RS06795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Mal52_RS06800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_RS06805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Mal52_RS06815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mal52_RS06820	COG0515	serine threonine protein kinase
Mal52_RS06835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Mal52_RS06840	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Mal52_RS06850	COG0107	imidazoleglycerol-phosphate synthase activity
Mal52_RS06860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_RS06875	COG0519	Catalyzes the synthesis of GMP from XMP
Mal52_RS06875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Mal52_RS06900	COG0583	DNA-binding transcription factor activity
Mal52_RS06940	COG5002	protein histidine kinase activity
Mal52_RS06960	COG4251	negative regulation of phosphorylation
Mal52_RS06965	COG0784	Response regulator, receiver
Mal52_RS07030	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Mal52_RS07040	COG1201	RNA secondary structure unwinding
Mal52_RS07045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mal52_RS07075	COG0275	rRNA processing
Mal52_RS07085	COG0564	pseudouridine synthase activity
Mal52_RS07095	COG0673	inositol 2-dehydrogenase activity
Mal52_RS07120	COG2115	Belongs to the xylose isomerase family
Mal52_RS07130	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_RS07135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Mal52_RS07165	COG3385	transposase activity
Mal52_RS07185	COG3118	belongs to the thioredoxin family
Mal52_RS07210	COG0616	signal peptide processing
Mal52_RS07280	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_RS07285	COG4786	Flagellar basal body rod
Mal52_RS07290	COG4786	Flagellar basal body rod
Mal52_RS07300	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Mal52_RS07305	COG1706	bacterial-type flagellum-dependent cell motility
Mal52_RS07320	COG4786	Flagellar basal body rod
Mal52_RS07320	COG1256	bacterial-type flagellum assembly
Mal52_RS07325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Mal52_RS07360	COG3119	arylsulfatase activity
Mal52_RS07400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mal52_RS07420	COG2308	Evidence 4 Homologs of previously reported genes of
Mal52_RS07450	COG2204	response regulator
Mal52_RS07455	COG3852	Histidine kinase
Mal52_RS07460	COG0288	reversible hydration of carbon dioxide
Mal52_RS07465	COG0667	Aldo Keto reductase
Mal52_RS07470	COG3119	arylsulfatase activity
Mal52_RS07480	COG4191	Histidine kinase
Mal52_RS07495	COG0673	inositol 2-dehydrogenase activity
Mal52_RS07525	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS07530	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Mal52_RS07560	COG0811	peptide transport
Mal52_RS07575	COG0516	GMP reductase activity
Mal52_RS07575	COG0517	IMP dehydrogenase activity
Mal52_RS07580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Mal52_RS07585	COG0307	riboflavin synthase, alpha
Mal52_RS07600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Mal52_RS07610	COG1331	Highly conserved protein containing a thioredoxin domain
Mal52_RS07615	COG0673	inositol 2-dehydrogenase activity
Mal52_RS07620	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Mal52_RS07645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mal52_RS07650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mal52_RS07655	COG0673	inositol 2-dehydrogenase activity
Mal52_RS07665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Mal52_RS07670	COG0131	Imidazoleglycerol-phosphate dehydratase
Mal52_RS07685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Mal52_RS07690	COG1012	belongs to the aldehyde dehydrogenase family
Mal52_RS07705	COG0604	alcohol dehydrogenase
Mal52_RS07715	COG3119	arylsulfatase activity
Mal52_RS07720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Mal52_RS07735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Mal52_RS07765	COG0475	glutathione-regulated potassium exporter activity
Mal52_RS07770	COG2815	serine threonine protein kinase
Mal52_RS07770	COG0515	serine threonine protein kinase
Mal52_RS07815	COG0768	penicillin binding
Mal52_RS07850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Mal52_RS07855	COG0187	DNA topoisomerase II activity
Mal52_RS07860	COG3119	arylsulfatase activity
Mal52_RS07865	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Mal52_RS07870	COG0402	S-adenosylhomocysteine deaminase activity
Mal52_RS07900	COG3119	arylsulfatase activity
Mal52_RS07905	COG1024	Enoyl-CoA hydratase
Mal52_RS07925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_RS07930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mal52_RS07935	COG0165	Argininosuccinate lyase
Mal52_RS07945	COG0515	serine threonine protein kinase
Mal52_RS07945	COG2815	serine threonine protein kinase
Mal52_RS07990	COG0704	Plays a role in the regulation of phosphate uptake
Mal52_RS08000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Mal52_RS08005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Mal52_RS08025	COG1040	competence protein
Mal52_RS08035	COG0181	hydroxymethylbilane synthase activity
Mal52_RS08095	COG0148	phosphopyruvate hydratase activity
Mal52_RS08100	COG0688	phosphatidylethanolamine metabolic process
Mal52_RS08105	COG1183	phosphatidylcholine synthase activity
Mal52_RS08115	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Mal52_RS08115	COG0493	'glutamate synthase
Mal52_RS08120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Mal52_RS08145	COG1222	aaa ATPase
Mal52_RS08160	COG0009	L-threonylcarbamoyladenylate synthase
Mal52_RS08175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mal52_RS08205	COG3119	arylsulfatase activity
Mal52_RS08210	COG0508	dehydrogenase complex catalyzes the overall conversion of
Mal52_RS08275	COG2815	serine threonine protein kinase
Mal52_RS08275	COG0515	serine threonine protein kinase
Mal52_RS08290	COG1477	protein flavinylation
Mal52_RS08295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_RS08330	COG3228	Belongs to the MtfA family
Mal52_RS08370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Mal52_RS08380	COG0151	Belongs to the GarS family
Mal52_RS08450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Mal52_RS08480	COG2211	Major facilitator Superfamily
Mal52_RS08505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Mal52_RS08535	COG2095	MarC family integral membrane protein
Mal52_RS08565	COG0515	serine threonine protein kinase
Mal52_RS08565	COG2815	serine threonine protein kinase
Mal52_RS08590	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Mal52_RS08615	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mal52_RS08620	COG1129	ABC transporter
Mal52_RS08635	COG3119	arylsulfatase activity
Mal52_RS08670	COG1131	(ABC) transporter
Mal52_RS08680	COG0714	Associated with various cellular activities
Mal52_RS08695	COG1091	dTDP-4-dehydrorhamnose reductase activity
Mal52_RS08705	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Mal52_RS08705	COG4106	trans-aconitate 2-methyltransferase activity
Mal52_RS08730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Mal52_RS08750	COG2226	methyltransferase
Mal52_RS08755	COG3956	TIGRFAM MazG family protein
Mal52_RS08760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_RS08765	COG0539	negative regulation of cytoplasmic translation
Mal52_RS08770	COG2195	Cleaves the N-terminal amino acid of tripeptides
Mal52_RS08795	COG3119	arylsulfatase activity
Mal52_RS08840	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS08890	COG0326	Molecular chaperone. Has ATPase activity
Mal52_RS08910	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
Mal52_RS08915	COG0189	ligase activity
Mal52_RS08930	COG1073	alpha beta
Mal52_RS08945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Mal52_RS08965	COG2255	four-way junction helicase activity
Mal52_RS09005	COG3540	Alkaline phosphatase
Mal52_RS09175	COG3119	arylsulfatase activity
Mal52_RS09185	COG0517	IMP dehydrogenase activity
Mal52_RS09185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Mal52_RS09185	COG0617	tRNA 3'-terminal CCA addition
Mal52_RS09295	COG1657	PFAM Prenyltransferase squalene oxidase
Mal52_RS09315	COG1129	ABC transporter
Mal52_RS09325	COG3386	PFAM SMP-30 Gluconolaconase
Mal52_RS09350	COG3706	GGDEF domain
Mal52_RS09360	COG0129	dihydroxy-acid dehydratase activity
Mal52_RS09365	COG1858	cytochrome C peroxidase
Mal52_RS09375	COG0784	Response regulator, receiver
Mal52_RS09390	COG2818	Glycosylase
Mal52_RS09440	COG2205	protein histidine kinase activity
Mal52_RS09440	COG3437	response regulator, receiver
Mal52_RS09440	COG4999	Histidine kinase
Mal52_RS09440	COG3850	Histidine kinase
Mal52_RS09445	COG2204	response regulator
Mal52_RS09455	COG0515	serine threonine protein kinase
Mal52_RS09460	COG1012	belongs to the aldehyde dehydrogenase family
Mal52_RS09495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Mal52_RS09495	COG0512	Glutamine amidotransferase of anthranilate synthase
Mal52_RS09505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Mal52_RS09520	COG1595	DNA-templated transcription, initiation
Mal52_RS09535	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_RS09540	COG0443	Heat shock 70 kDa protein
Mal52_RS09550	COG0205	6-phosphofructokinase activity
Mal52_RS09560	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Mal52_RS09570	COG1234	tRNA 3'-trailer cleavage
Mal52_RS09575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mal52_RS09580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Mal52_RS09585	COG3119	arylsulfatase activity
Mal52_RS09610	COG0714	Associated with various cellular activities
Mal52_RS09655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Mal52_RS09665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Mal52_RS09670	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS09675	COG1070	Carbohydrate kinase
Mal52_RS09720	COG3119	arylsulfatase activity
Mal52_RS09760	COG0745	RESPONSE REGULATOR receiver
Mal52_RS09800	COG0438	transferase activity, transferring glycosyl groups
Mal52_RS09800	COG1216	Glycosyl transferase, family 2
Mal52_RS09830	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Mal52_RS09915	COG0367	asparagine synthase
Mal52_RS09920	COG0438	transferase activity, transferring glycosyl groups
Mal52_RS09925	COG1505	serine-type exopeptidase activity
Mal52_RS09930	COG0438	transferase activity, transferring glycosyl groups
Mal52_RS09935	COG0457	Tetratricopeptide repeat
Mal52_RS09940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Mal52_RS09950	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Mal52_RS09955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Mal52_RS09990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mal52_RS09995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mal52_RS10010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Mal52_RS10045	COG2062	phosphohistidine phosphatase, SixA
Mal52_RS10050	COG0066	3-isopropylmalate dehydratase activity
Mal52_RS10055	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Mal52_RS10060	COG0575	Belongs to the CDS family
Mal52_RS10065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Mal52_RS10070	COG1229	Formylmethanofuran dehydrogenase subunit A
Mal52_RS10100	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mal52_RS10110	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Mal52_RS10145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mal52_RS10155	COG2130	NADP-dependent
Mal52_RS10170	COG0653	protein targeting
Mal52_RS10185	COG0247	lactate metabolic process
Mal52_RS10190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Mal52_RS10195	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Mal52_RS10215	COG0673	inositol 2-dehydrogenase activity
Mal52_RS10240	COG2322	membrane
Mal52_RS10250	COG1131	(ABC) transporter
Mal52_RS10265	COG0109	protoheme IX farnesyltransferase activity
Mal52_RS10275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Mal52_RS10280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Mal52_RS10305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Mal52_RS10310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Mal52_RS10340	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_RS10380	COG0443	Heat shock 70 kDa protein
Mal52_RS10395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_RS10405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Mal52_RS10465	COG0406	alpha-ribazole phosphatase activity
Mal52_RS10485	COG0673	inositol 2-dehydrogenase activity
Mal52_RS10515	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Mal52_RS10520	COG0438	transferase activity, transferring glycosyl groups
Mal52_RS10525	COG2001	Belongs to the MraZ family
Mal52_RS10530	COG0275	rRNA processing
Mal52_RS10545	COG0768	penicillin binding
Mal52_RS10550	COG0011	TIGRFAM Protein of
Mal52_RS10555	COG0426	domain, Protein
Mal52_RS10555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Mal52_RS10560	COG0277	FAD linked oxidase domain protein
Mal52_RS10565	COG0277	FAD linked oxidase domain protein
Mal52_RS10570	COG0659	secondary active sulfate transmembrane transporter activity
Mal52_RS10575	COG2815	serine threonine protein kinase
Mal52_RS10575	COG0515	serine threonine protein kinase
Mal52_RS10590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_RS10610	COG4191	Histidine kinase
Mal52_RS10680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Mal52_RS10695	COG0463	Glycosyl transferase, family 2
Mal52_RS10790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Mal52_RS10795	COG3481	metal-dependent phosphohydrolase, HD sub domain
Mal52_RS10830	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Mal52_RS10835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Mal52_RS10865	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mal52_RS10885	COG5002	protein histidine kinase activity
Mal52_RS10895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Mal52_RS10900	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Mal52_RS10930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mal52_RS10935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Mal52_RS10940	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Mal52_RS10945	COG0736	holo-[acyl-carrier-protein] synthase activity
Mal52_RS10955	COG0180	Tryptophanyl-tRNA synthetase
Mal52_RS10960	COG0167	dihydroorotate dehydrogenase activity
Mal52_RS10985	COG0303	'Molybdopterin
Mal52_RS10990	COG0303	'Molybdopterin
Mal52_RS11030	COG0473	3-isopropylmalate dehydrogenase activity
Mal52_RS11070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Mal52_RS11075	COG1519	Transferase
Mal52_RS11080	COG0653	protein targeting
Mal52_RS11085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Mal52_RS11095	COG3119	arylsulfatase activity
Mal52_RS11145	COG0477	Major facilitator Superfamily
Mal52_RS11155	COG0195	Participates in both transcription termination and antitermination
Mal52_RS11155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Mal52_RS11160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Mal52_RS11165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Mal52_RS11180	COG0217	transcriptional regulatory protein
Mal52_RS11210	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mal52_RS11210	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Mal52_RS11210	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mal52_RS11210	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mal52_RS11215	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mal52_RS11220	COG2040	homocysteine
Mal52_RS11230	COG1466	dna polymerase III delta subunit
Mal52_RS11235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Mal52_RS11275	COG0519	Catalyzes the synthesis of GMP from XMP
Mal52_RS11275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Mal52_RS11325	COG1253	flavin adenine dinucleotide binding
Mal52_RS11330	COG0598	Magnesium transport protein CorA
Mal52_RS11335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Mal52_RS11350	COG0039	L-malate dehydrogenase activity
Mal52_RS11355	COG0235	Class ii aldolase
Mal52_RS11390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Mal52_RS11395	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Mal52_RS11400	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Mal52_RS11405	COG4869	propanediol catabolic process
Mal52_RS11410	COG1349	DNA-binding transcription factor activity
Mal52_RS11415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Mal52_RS11425	COG3118	belongs to the thioredoxin family
Mal52_RS11445	COG0693	protein deglycase activity
Mal52_RS11455	COG3385	transposase activity
Mal52_RS11460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Mal52_RS11485	COG0577	efflux transmembrane transporter activity
Mal52_RS11485	COG1136	(ABC) transporter
Mal52_RS11490	COG1136	(ABC) transporter
Mal52_RS11525	COG0714	Associated with various cellular activities
Mal52_RS11530	COG3119	arylsulfatase activity
Mal52_RS11540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mal52_RS11555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Mal52_RS11560	COG0673	inositol 2-dehydrogenase activity
Mal52_RS11570	COG4106	trans-aconitate 2-methyltransferase activity
Mal52_RS11575	COG0728	peptidoglycan biosynthetic process
Mal52_RS11610	COG0733	neurotransmitter:sodium symporter activity
Mal52_RS11640	COG1490	D-aminoacyl-tRNA deacylase activity
Mal52_RS11645	COG0825	malonyl-CoA metabolic process
Mal52_RS11670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Mal52_RS11685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Mal52_RS11690	COG0363	glucosamine-6-phosphate deaminase activity
Mal52_RS11695	COG0823	Involved in the tonB-independent uptake of proteins
Mal52_RS11710	COG1073	alpha beta
Mal52_RS11715	COG0372	Belongs to the citrate synthase family
Mal52_RS11725	COG2813	Specifically methylates the guanine in position
Mal52_RS11765	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS11780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mal52_RS11795	COG1053	succinate dehydrogenase
Mal52_RS11805	COG0557	exoribonuclease II activity
Mal52_RS11810	COG0277	FAD linked oxidase domain protein
Mal52_RS11825	COG0564	pseudouridine synthase activity
Mal52_RS11845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Mal52_RS11875	COG1024	Enoyl-CoA hydratase
Mal52_RS11920	COG0793	Belongs to the peptidase S41A family
Mal52_RS11925	COG1131	(ABC) transporter
Mal52_RS11950	COG0222	ribosome binding
Mal52_RS11960	COG0148	phosphopyruvate hydratase activity
Mal52_RS11975	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Mal52_RS11985	COG2079	MmgE PrpD family protein
Mal52_RS12000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Mal52_RS12065	COG0004	ammonium transporteR
Mal52_RS12070	COG0347	Belongs to the P(II) protein family
Mal52_RS12120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Mal52_RS12140	COG1181	Belongs to the D-alanine--D-alanine ligase family
Mal52_RS12145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Mal52_RS12160	COG2208	phosphoserine phosphatase activity
Mal52_RS12160	COG2770	Histidine kinase
Mal52_RS12165	COG3119	arylsulfatase activity
Mal52_RS12200	COG1127	ABC transporter
Mal52_RS12205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Mal52_RS12215	COG3119	arylsulfatase activity
Mal52_RS12240	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS12250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mal52_RS12270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Mal52_RS12275	COG0459	protein refolding
Mal52_RS12295	COG0137	argininosuccinate synthase activity
Mal52_RS12300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Mal52_RS12350	COG1459	type II secretion system
Mal52_RS12355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_RS12390	COG4796	Type ii and iii secretion system protein
Mal52_RS12420	COG1312	Catalyzes the dehydration of D-mannonate
Mal52_RS12445	COG2226	methyltransferase
Mal52_RS12450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Mal52_RS12455	COG0698	ribose 5-phosphate isomerase
Mal52_RS12460	COG0509	glycine decarboxylation via glycine cleavage system
Mal52_RS12465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Mal52_RS12470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Mal52_RS12475	COG0095	Lipoate-protein ligase
Mal52_RS12480	COG1716	ATPase activity
Mal52_RS12495	COG2770	Histidine kinase
Mal52_RS12495	COG2208	phosphoserine phosphatase activity
Mal52_RS12530	COG0235	Class ii aldolase
Mal52_RS12560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Mal52_RS12565	COG0126	phosphoglycerate kinase activity
Mal52_RS12575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_RS12575	COG3320	Male sterility
Mal52_RS12580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Mal52_RS12585	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Mal52_RS12590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Mal52_RS12595	COG0237	dephospho-CoA kinase activity
Mal52_RS12600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Mal52_RS12600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Mal52_RS12615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_RS12620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Mal52_RS12630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Mal52_RS12635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_RS12640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_RS12700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Mal52_RS12705	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Mal52_RS12710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Mal52_RS12725	COG0556	nucleotide-excision repair
Mal52_RS12750	COG1073	alpha beta
Mal52_RS12755	COG0384	phenazine biosynthesis protein PhzF
Mal52_RS12810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Mal52_RS12810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Mal52_RS12835	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Mal52_RS12860	COG1045	serine acetyltransferase
Mal52_RS12885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Mal52_RS12895	COG0386	Belongs to the glutathione peroxidase family
Mal52_RS12910	COG4864	UPF0365 protein
Mal52_RS12950	COG4249	Peptidase C14 caspase catalytic subunit p20
Mal52_RS13010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mal52_RS13050	COG3002	Belongs to the UPF0753 family
Mal52_RS13055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Mal52_RS13060	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mal52_RS13080	COG0604	alcohol dehydrogenase
Mal52_RS13080	COG3321	synthase
Mal52_RS13085	COG0702	epimerase
Mal52_RS13110	COG3795	YCII-related domain
Mal52_RS13130	COG3795	YCII-related domain
Mal52_RS13145	COG4941	Belongs to the sigma-70 factor family
Mal52_RS13175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_RS13175	COG0515	serine threonine protein kinase
Mal52_RS13200	COG0515	serine threonine protein kinase
Mal52_RS13200	COG2815	serine threonine protein kinase
Mal52_RS13220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Mal52_RS13235	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Mal52_RS13280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Mal52_RS13330	COG1475	DNA binding
Mal52_RS13395	COG3119	arylsulfatase activity
Mal52_RS13415	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Mal52_RS13415	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Mal52_RS13430	COG0204	Acyl-transferase
Mal52_RS13430	COG0318	PFAM AMP-dependent synthetase and ligase
Mal52_RS13445	COG4294	response to UV
Mal52_RS13480	COG1285	pathogenesis
Mal52_RS13505	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Mal52_RS13520	COG1606	tRNA processing
Mal52_RS13550	COG0463	Glycosyl transferase, family 2
Mal52_RS13575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Mal52_RS13585	COG0527	aspartate kinase activity
Mal52_RS13620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Mal52_RS13650	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_RS13675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Mal52_RS13680	COG0321	lipoyl(octanoyl) transferase activity
Mal52_RS13685	COG1160	GTP binding
Mal52_RS13690	COG1562	ergosterol biosynthetic process
Mal52_RS13695	COG1562	ergosterol biosynthetic process
Mal52_RS13700	COG0515	serine threonine protein kinase
Mal52_RS13700	COG2815	serine threonine protein kinase
Mal52_RS13705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Mal52_RS13740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mal52_RS13750	COG0463	Glycosyl transferase, family 2
Mal52_RS13760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Mal52_RS13765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Mal52_RS13770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Mal52_RS13810	COG0135	phosphoribosylanthranilate isomerase activity
Mal52_RS13820	COG2832	Protein of unknown function (DUF454)
Mal52_RS13825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mal52_RS13840	COG4336	lyase activity
Mal52_RS13870	COG4191	Histidine kinase
Mal52_RS13925	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Mal52_RS13925	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Mal52_RS13970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Mal52_RS13990	COG2165	general secretion pathway protein
Mal52_RS14085	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
Mal52_RS14100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_RS14105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_RS14110	COG1233	COG1233 Phytoene dehydrogenase and related
Mal52_RS14120	COG0402	S-adenosylhomocysteine deaminase activity
Mal52_RS14125	COG1187	pseudouridine synthase activity
Mal52_RS14130	COG0543	2 iron, 2 sulfur cluster binding
Mal52_RS14155	COG2172	sigma factor antagonist activity
Mal52_RS14165	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mal52_RS14175	COG2132	Multicopper oxidase
Mal52_RS14235	COG1475	DNA binding
Mal52_RS14310	COG0420	3'-5' exonuclease activity
Mal52_RS14315	COG4717	serine-type aminopeptidase activity
Mal52_RS14315	COG4717	serine-type aminopeptidase activity
Mal52_RS14355	COG3209	COG3209 Rhs family protein
Mal52_RS14370	COG3209	COG3209 Rhs family protein
Mal52_RS14380	COG1450	Type ii and iii secretion system protein
Mal52_RS14385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_RS14435	COG1459	type II secretion system
Mal52_RS14500	COG3645	SOS response
Mal52_RS14575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Mal52_RS14590	COG1475	DNA binding
Mal52_RS14655	COG0714	Associated with various cellular activities
Mal52_RS14665	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Mal52_RS14670	COG0668	transmembrane transport
Mal52_RS14675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Mal52_RS14690	COG1566	PFAM secretion protein HlyD family protein
Mal52_RS14720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Mal52_RS14730	COG0589	response to stress
Mal52_RS14735	COG0515	serine threonine protein kinase
Mal52_RS14755	COG1309	transcriptional regulator
Mal52_RS14775	COG0457	Tetratricopeptide repeat
Mal52_RS14775	COG0515	serine threonine protein kinase
Mal52_RS14785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mal52_RS14845	COG3541	Predicted nucleotidyltransferase
Mal52_RS14855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Mal52_RS14895	COG3119	arylsulfatase activity
Mal52_RS14910	COG0577	efflux transmembrane transporter activity
Mal52_RS14910	COG1136	(ABC) transporter
Mal52_RS14970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mal52_RS14980	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
Mal52_RS15015	COG2815	serine threonine protein kinase
Mal52_RS15015	COG0515	serine threonine protein kinase
Mal52_RS15020	COG1842	Phage shock protein A
Mal52_RS15055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Mal52_RS15065	COG2204	response regulator
Mal52_RS15070	COG4191	Histidine kinase
Mal52_RS15075	COG1320	monovalent cation:proton antiporter activity
Mal52_RS15080	COG2212	antiporter activity
Mal52_RS15085	COG1863	multisubunit Na H antiporter MnhE subunit
Mal52_RS15090	COG0651	ATP synthesis coupled electron transport
Mal52_RS15095	COG1006	Multisubunit Na H antiporter MnhC subunit
Mal52_RS15100	COG2111	Na H antiporter
Mal52_RS15105	COG2111	Na H antiporter
Mal52_RS15105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Mal52_RS15110	COG3189	MarR family transcriptional regulator
Mal52_RS15125	COG4968	Prepilin-type N-terminal cleavage methylation domain
Mal52_RS15150	COG0714	Associated with various cellular activities
Mal52_RS15175	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Mal52_RS15205	COG0443	Heat shock 70 kDa protein
Mal52_RS15230	COG0784	Response regulator, receiver
Mal52_RS15230	COG5002	protein histidine kinase activity
Mal52_RS15230	COG2205	protein histidine kinase activity
Mal52_RS15235	COG3437	response regulator, receiver
Mal52_RS15240	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Mal52_RS15250	COG0702	epimerase
Mal52_RS15265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mal52_RS15270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mal52_RS15280	COG1231	oxidoreductase activity
Mal52_RS15285	COG0123	including yeast histone deacetylase and acetoin utilization protein
Mal52_RS15290	COG0045	succinate-CoA ligase (ADP-forming) activity
Mal52_RS15290	COG1042	CoA-binding domain protein
Mal52_RS15290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Mal52_RS15305	COG2226	methyltransferase
Mal52_RS15365	COG3540	Alkaline phosphatase
Mal52_RS15375	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Mal52_RS15380	COG1017	nitric oxide dioxygenase activity
Mal52_RS15380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Mal52_RS15385	COG1959	2 iron, 2 sulfur cluster binding
Mal52_RS15395	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Mal52_RS15415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_RS15420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Mal52_RS15425	COG2971	BadF BadG BcrA BcrD
Mal52_RS15465	COG0564	pseudouridine synthase activity
Mal52_RS15505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Mal52_RS15515	COG2815	serine threonine protein kinase
Mal52_RS15515	COG0515	serine threonine protein kinase
Mal52_RS15555	COG1136	(ABC) transporter
Mal52_RS15560	COG0577	efflux transmembrane transporter activity
Mal52_RS15560	COG1136	(ABC) transporter
Mal52_RS15565	COG0243	molybdopterin cofactor binding
Mal52_RS15570	COG0437	4 iron, 4 sulfur cluster binding
Mal52_RS15575	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Mal52_RS15580	COG2223	nitrite transmembrane transporter activity
Mal52_RS15645	COG0530	calcium, potassium:sodium antiporter activity
Mal52_RS15660	COG0443	Heat shock 70 kDa protein
Mal52_RS15670	COG0515	serine threonine protein kinase
Mal52_RS15675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Mal52_RS15685	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mal52_RS15720	COG2261	transglycosylase associated protein
Mal52_RS15725	COG0523	cobalamin synthesis protein
Mal52_RS15730	COG1234	tRNA 3'-trailer cleavage
Mal52_RS15735	COG2321	neutral zinc metallopeptidase
Mal52_RS15740	COG0668	transmembrane transport
Mal52_RS15760	COG0653	protein targeting
Mal52_RS15910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mal52_RS15915	COG1940	carbohydrate kinase activity
Mal52_RS15940	COG0513	Belongs to the DEAD box helicase family
Mal52_RS15945	COG3119	arylsulfatase activity
Mal52_RS15980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Mal52_RS15985	COG0436	Aminotransferase
Mal52_RS15995	COG1408	metallophosphoesterase
Mal52_RS16005	COG0277	FAD linked oxidase domain protein
Mal52_RS16005	COG0247	lactate metabolic process
Mal52_RS16010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Mal52_RS16020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Mal52_RS16045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Mal52_RS16050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mal52_RS16130	COG0659	secondary active sulfate transmembrane transporter activity
Mal52_RS16135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Mal52_RS16155	COG1702	phosphate starvation-inducible protein PhoH
Mal52_RS16160	COG1480	7TM receptor with intracellular HD hydrolase
Mal52_RS16165	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Mal52_RS16185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mal52_RS16185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mal52_RS16190	COG0114	fumarate hydratase activity
Mal52_RS16250	COG0859	PFAM glycosyl transferase family 9
Mal52_RS16250	COG0457	Tetratricopeptide repeat
Mal52_RS16265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Mal52_RS16300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Mal52_RS16310	COG3119	arylsulfatase activity
Mal52_RS16320	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS16370	COG1482	cell wall glycoprotein biosynthetic process
Mal52_RS16380	COG2855	membrane
Mal52_RS16420	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Mal52_RS16450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_RS16455	COG0318	PFAM AMP-dependent synthetase and ligase
Mal52_RS16475	COG0823	Involved in the tonB-independent uptake of proteins
Mal52_RS16515	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Mal52_RS16525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Mal52_RS16530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Mal52_RS16560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_RS16565	COG3119	arylsulfatase activity
Mal52_RS16585	COG0456	acetyltransferase
Mal52_RS16590	COG0612	Peptidase, M16
Mal52_RS16595	COG0612	Peptidase, M16
Mal52_RS16600	COG3361	conserved protein (COG2071)
Mal52_RS16605	COG1278	Cold shock
Mal52_RS16610	COG0434	BtpA family
Mal52_RS16615	COG0534	Mate efflux family protein
Mal52_RS16665	COG1073	alpha beta
Mal52_RS16735	COG3264	Mechanosensitive ion channel
Mal52_RS16735	COG1196	nuclear chromosome segregation
Mal52_RS16770	COG1132	(ABC) transporter
Mal52_RS16775	COG1283	sodium-dependent phosphate transmembrane transporter activity
Mal52_RS16795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Mal52_RS16795	COG0321	lipoyl(octanoyl) transferase activity
Mal52_RS16805	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Mal52_RS16810	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Mal52_RS16830	COG1191	sigma factor activity
Mal52_RS16840	COG0455	bacterial-type flagellum organization
Mal52_RS16845	COG1419	protein localization to endoplasmic reticulum
Mal52_RS16850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Mal52_RS16865	COG4589	Belongs to the CDS family
Mal52_RS16875	COG2267	carboxylic ester hydrolase activity
Mal52_RS16880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Mal52_RS16900	COG0673	inositol 2-dehydrogenase activity
Mal52_RS16905	COG0617	tRNA 3'-terminal CCA addition
Mal52_RS16910	COG0205	6-phosphofructokinase activity
Mal52_RS16915	COG0439	Biotin carboxylase
Mal52_RS16920	COG0511	ligase activity, forming carbon-carbon bonds
Mal52_RS16925	COG0006	proline dipeptidase activity
Mal52_RS16935	COG1136	(ABC) transporter
Mal52_RS16935	COG0577	efflux transmembrane transporter activity
Mal52_RS16950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_RS16960	COG1058	Belongs to the CinA family
Mal52_RS16960	COG1546	Belongs to the CinA family
Mal52_RS16975	COG4864	UPF0365 protein
Mal52_RS17000	COG0811	peptide transport
Mal52_RS17005	COG0848	biopolymer transport protein
Mal52_RS17015	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Mal52_RS17020	COG2815	serine threonine protein kinase
Mal52_RS17020	COG0515	serine threonine protein kinase
Mal52_RS17045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Mal52_RS17065	COG0656	L-ascorbic acid biosynthetic process
Mal52_RS17080	COG0438	transferase activity, transferring glycosyl groups
Mal52_RS17110	COG1073	alpha beta
Mal52_RS17130	COG3153	acetyltransferase
Mal52_RS17135	COG1136	(ABC) transporter
Mal52_RS17155	COG4566	intracellular signal transduction
Mal52_RS17160	COG4191	Histidine kinase
Mal52_RS17200	COG1136	(ABC) transporter
Mal52_RS17215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Mal52_RS17220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Mal52_RS17255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Mal52_RS17285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Mal52_RS17290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Mal52_RS17295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Mal52_RS17305	COG2385	sporulation resulting in formation of a cellular spore
Mal52_RS17310	COG0202	RNA polymerase activity
Mal52_RS17340	COG0045	succinate-CoA ligase (ADP-forming) activity
Mal52_RS17345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Mal52_RS17350	COG0105	UTP biosynthetic process
Mal52_RS17365	COG1131	(ABC) transporter
Mal52_RS17415	COG0515	serine threonine protein kinase
Mal52_RS17415	COG2815	serine threonine protein kinase
Mal52_RS17555	COG1192	Involved in chromosome partitioning
Mal52_RS17570	COG5433	transposase activity
Mal52_RS17630	COG1278	Cold shock
Mal52_RS17665	COG0673	inositol 2-dehydrogenase activity
Mal52_RS17705	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Mal52_RS17710	COG3781	membrane
Mal52_RS17715	COG0515	serine threonine protein kinase
Mal52_RS17715	COG2815	serine threonine protein kinase
Mal52_RS17810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Mal52_RS17825	COG0116	Belongs to the methyltransferase superfamily
Mal52_RS17830	COG0745	RESPONSE REGULATOR receiver
Mal52_RS17855	COG3959	Transketolase, thiamine diphosphate binding domain
Mal52_RS17860	COG3958	Transketolase
Mal52_RS17870	COG2062	phosphohistidine phosphatase, SixA
Mal52_RS17890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Mal52_RS17915	COG0657	acetylesterase activity
Mal52_RS17920	COG1073	alpha beta
Mal52_RS17930	COG0673	inositol 2-dehydrogenase activity
Mal52_RS17955	COG0673	inositol 2-dehydrogenase activity
Mal52_RS17960	COG4566	intracellular signal transduction
Mal52_RS18050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Mal52_RS18055	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Mal52_RS18060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Mal52_RS18065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Mal52_RS18070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Mal52_RS18080	COG1045	serine acetyltransferase
Mal52_RS18105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Mal52_RS18115	COG1940	carbohydrate kinase activity
Mal52_RS18120	COG0481	GTPase activity
Mal52_RS18135	COG1137	ATPase activity
Mal52_RS18145	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS18170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Mal52_RS18175	COG1217	gtp-binding protein TYPA
Mal52_RS18200	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS18205	COG2022	thiamine diphosphate biosynthetic process
Mal52_RS18215	COG4112	unkown
Mal52_RS18235	COG2204	response regulator
Mal52_RS18240	COG4191	Histidine kinase
Mal52_RS18245	COG0297	glycogen (starch) synthase activity
Mal52_RS18280	COG0367	asparagine synthase
Mal52_RS18285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Mal52_RS18325	COG0714	Associated with various cellular activities
Mal52_RS18370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_RS18380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Mal52_RS18385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Mal52_RS18440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_RS18485	COG1450	Type ii and iii secretion system protein
Mal52_RS18505	COG0673	inositol 2-dehydrogenase activity
Mal52_RS18520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Mal52_RS18525	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mal52_RS18545	COG0859	PFAM glycosyl transferase family 9
Mal52_RS18570	COG0719	Fe-S assembly protein
Mal52_RS18575	COG0719	Fe-S assembly protein
Mal52_RS18585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mal52_RS18595	COG1115	amino acid carrier protein
Mal52_RS18600	COG0589	response to stress
Mal52_RS18620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Mal52_RS18630	COG0071	Belongs to the small heat shock protein (HSP20) family
Mal52_RS18635	COG0071	Belongs to the small heat shock protein (HSP20) family
Mal52_RS18660	COG0589	response to stress
Mal52_RS18670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Mal52_RS18710	COG0586	Pfam SNARE associated Golgi protein
Mal52_RS18720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Mal52_RS18730	COG3842	ATPase activity
Mal52_RS18750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Mal52_RS18760	COG0490	domain, Protein
Mal52_RS18760	COG2985	domain, Protein
Mal52_RS18770	COG1959	2 iron, 2 sulfur cluster binding
Mal52_RS18775	COG1879	ABC-type sugar transport system periplasmic component
Mal52_RS18795	COG0113	porphobilinogen synthase activity
Mal52_RS18815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Mal52_RS18820	COG0793	Belongs to the peptidase S41A family
Mal52_RS18825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Mal52_RS18865	COG3119	arylsulfatase activity
Mal52_RS18875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_RS18885	COG1063	alcohol dehydrogenase
Mal52_RS18910	COG1449	Belongs to the glycosyl hydrolase 57 family
Mal52_RS18925	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Mal52_RS18975	COG3253	May function as heme-dependent peroxidase
Mal52_RS18985	COG1129	ABC transporter
Mal52_RS19030	COG0745	RESPONSE REGULATOR receiver
Mal52_RS19035	COG5002	protein histidine kinase activity
Mal52_RS19045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mal52_RS19090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Mal52_RS19095	COG0037	tRNA processing
Mal52_RS19105	COG1418	mRNA catabolic process
Mal52_RS19115	COG0657	acetylesterase activity
Mal52_RS19170	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS19195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Mal52_RS19200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Mal52_RS19205	COG3119	arylsulfatase activity
Mal52_RS19225	COG3118	belongs to the thioredoxin family
Mal52_RS19230	COG3604	Transcriptional regulator
Mal52_RS19245	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Mal52_RS19275	COG0584	glycerophosphoryl diester phosphodiesterase
Mal52_RS19370	COG0385	Bile acid
Mal52_RS19375	COG0154	amidase activity
Mal52_RS19380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mal52_RS19385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Mal52_RS19390	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_RS19420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mal52_RS19435	COG1959	2 iron, 2 sulfur cluster binding
Mal52_RS19450	COG4191	Histidine kinase
Mal52_RS19485	COG0481	GTPase activity
Mal52_RS19505	COG3537	Alpha-1,2-mannosidase
Mal52_RS19515	COG0745	RESPONSE REGULATOR receiver
Mal52_RS19520	COG2205	protein histidine kinase activity
Mal52_RS19540	COG0072	phenylalanine-tRNA ligase activity
Mal52_RS19565	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS19580	COG0590	tRNA wobble adenosine to inosine editing
Mal52_RS19630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mal52_RS19675	COG1162	GTPase activity
Mal52_RS19690	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS19695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_RS19710	COG1058	Belongs to the CinA family
Mal52_RS19710	COG1546	Belongs to the CinA family
Mal52_RS19725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Mal52_RS19730	COG0574	Belongs to the PEP-utilizing enzyme family
Mal52_RS19730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Mal52_RS19735	COG0784	Response regulator, receiver
Mal52_RS19740	COG3119	arylsulfatase activity
Mal52_RS19785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mal52_RS19795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mal52_RS19800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mal52_RS19805	COG2897	thiosulfate sulfurtransferase activity
Mal52_RS19810	COG2815	serine threonine protein kinase
Mal52_RS19810	COG0515	serine threonine protein kinase
Mal52_RS19845	COG3394	polysaccharide catabolic process
Mal52_RS19905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Mal52_RS19910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Mal52_RS19935	COG5564	TIM-barrel signal transduction protein
Mal52_RS19955	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS19980	COG3437	response regulator, receiver
Mal52_RS19990	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS20025	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_RS20050	COG0129	dihydroxy-acid dehydratase activity
Mal52_RS20055	COG2204	response regulator
Mal52_RS20070	COG0442	prolyl-tRNA aminoacylation
Mal52_RS20080	COG0432	Pfam Uncharacterised protein family UPF0047
Mal52_RS20090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Mal52_RS20090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Mal52_RS20105	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Mal52_RS20105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Mal52_RS20110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Mal52_RS20115	COG0617	tRNA 3'-terminal CCA addition
Mal52_RS20125	COG2719	SpoVR family
Mal52_RS20130	COG2718	Belongs to the UPF0229 family
Mal52_RS20135	COG2766	serine protein kinase
Mal52_RS20140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_RS20170	COG2201	protein-glutamate methylesterase activity
Mal52_RS20180	COG2198	Histidine kinase
Mal52_RS20180	COG0784	Response regulator, receiver
Mal52_RS20180	COG0643	Histidine kinase
Mal52_RS20185	COG0612	Peptidase, M16
Mal52_RS20210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Mal52_RS20210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mal52_RS20275	COG2815	serine threonine protein kinase
Mal52_RS20275	COG0515	serine threonine protein kinase
Mal52_RS20295	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Mal52_RS20305	COG2183	response to ionizing radiation
Mal52_RS20320	COG4191	Histidine kinase
Mal52_RS20420	COG0134	indole-3-glycerol-phosphate synthase activity
Mal52_RS20480	COG0714	Associated with various cellular activities
Mal52_RS20500	COG1131	(ABC) transporter
Mal52_RS20520	COG1131	(ABC) transporter
Mal52_RS20555	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Mal52_RS20555	COG1918	ferrous iron import across plasma membrane
Mal52_RS20565	COG3383	formate dehydrogenase (NAD+) activity
Mal52_RS20590	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Mal52_RS20600	COG0179	Fumarylacetoacetate (FAA) hydrolase
Mal52_RS20615	COG0515	serine threonine protein kinase
Mal52_RS20630	COG2197	response regulator
Mal52_RS20650	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_RS20695	COG0154	amidase activity
Mal52_RS20745	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Mal52_RS20750	COG0839	Belongs to the complex I subunit 6 family
Mal52_RS20755	COG0713	ATP synthesis coupled electron transport
Mal52_RS20760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Mal52_RS20770	COG1007	ATP synthesis coupled electron transport
Mal52_RS20780	COG0084	hydrolase, TatD family'
Mal52_RS20790	COG0495	leucyl-tRNA aminoacylation
Mal52_RS20800	COG0569	domain protein
Mal52_RS20805	COG1454	alcohol dehydrogenase
Mal52_RS20840	COG2815	serine threonine protein kinase
Mal52_RS20840	COG0515	serine threonine protein kinase
Mal52_RS20855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mal52_RS20860	COG0109	protoheme IX farnesyltransferase activity
Mal52_RS20880	COG3119	arylsulfatase activity
Mal52_RS20880	COG3408	Glycogen debranching enzyme
Mal52_RS20950	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Mal52_RS20955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Mal52_RS20980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Mal52_RS20985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Mal52_RS20990	COG2852	Protein conserved in bacteria
Mal52_RS20995	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_RS21000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mal52_RS21005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mal52_RS21105	COG0673	inositol 2-dehydrogenase activity
Mal52_RS21145	COG2721	sulfolactate sulfo-lyase activity
Mal52_RS21270	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Mal52_RS21275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Mal52_RS21280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Mal52_RS21285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Mal52_RS21305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Mal52_RS21335	COG0577	efflux transmembrane transporter activity
Mal52_RS21340	COG1136	(ABC) transporter
Mal52_RS21380	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS21450	COG0471	metal ion transport
Mal52_RS21450	COG3273	potassium ion transport
Mal52_RS21480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Mal52_RS21490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Mal52_RS21495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Mal52_RS21510	COG5002	protein histidine kinase activity
Mal52_RS21515	COG0745	RESPONSE REGULATOR receiver
Mal52_RS21530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Mal52_RS21535	COG0233	cytoplasmic translational termination
Mal52_RS21540	COG0528	UMP kinase activity
Mal52_RS21580	COG0588	phosphoglycerate mutase activity
Mal52_RS21600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Mal52_RS21605	COG3119	arylsulfatase activity
Mal52_RS21615	COG2373	Large extracellular alpha-helical protein
Mal52_RS21620	COG1757	Na H antiporter
Mal52_RS21625	COG3852	Histidine kinase
Mal52_RS21635	COG0445	tRNA wobble uridine modification
Mal52_RS21640	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Mal52_RS21645	COG2962	Rard protein
Mal52_RS21650	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Mal52_RS21655	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS21685	COG1136	(ABC) transporter
Mal52_RS21690	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mal52_RS21695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Mal52_RS21760	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Mal52_RS21775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_RS21795	COG2192	nodulation
Mal52_RS21805	COG1131	(ABC) transporter
Mal52_RS21850	COG0405	Gamma-glutamyltransferase
Mal52_RS21855	COG1691	(AIR) carboxylase
Mal52_RS21885	COG0542	response to heat
Mal52_RS21890	COG0504	CTP synthase activity
Mal52_RS21895	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Mal52_RS21900	COG0459	protein refolding
Mal52_RS21905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Mal52_RS21910	COG0459	protein refolding
Mal52_RS21915	COG0484	heat shock protein binding
Mal52_RS21920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Mal52_RS21945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Mal52_RS21950	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Mal52_RS21955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Mal52_RS21960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Mal52_RS21965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Mal52_RS21970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Mal52_RS21975	COG2084	Dehydrogenase
Mal52_RS22025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Mal52_RS22035	COG0019	diaminopimelate decarboxylase activity
Mal52_RS22055	COG2204	response regulator
Mal52_RS22150	COG1528	Iron-storage protein
Mal52_RS22270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mal52_RS22275	COG0539	negative regulation of cytoplasmic translation
Mal52_RS22275	COG2183	response to ionizing radiation
Mal52_RS22290	COG1022	Amp-dependent synthetase and ligase
Mal52_RS22295	COG0183	Belongs to the thiolase family
Mal52_RS22305	COG0179	Fumarylacetoacetate (FAA) hydrolase
Mal52_RS22330	COG0529	Catalyzes the synthesis of activated sulfate
Mal52_RS22350	COG0745	RESPONSE REGULATOR receiver
Mal52_RS22360	COG2205	protein histidine kinase activity
Mal52_RS22400	COG4191	Histidine kinase
Mal52_RS22405	COG0784	Response regulator, receiver
Mal52_RS22410	COG4191	Histidine kinase
Mal52_RS22420	COG3437	response regulator, receiver
Mal52_RS22475	COG1131	(ABC) transporter
Mal52_RS22485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Mal52_RS22485	COG1754	DNA topoisomerase type I activity
Mal52_RS22495	COG2226	methyltransferase
Mal52_RS22505	COG1136	(ABC) transporter
Mal52_RS22510	COG4591	ABC-type transport system involved in lipoprotein release permease component
Mal52_RS22520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mal52_RS22525	COG0124	histidyl-tRNA synthetase
Mal52_RS22545	COG0564	pseudouridine synthase activity
Mal52_RS22565	COG0805	protein transport
Mal52_RS22575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Mal52_RS22580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Mal52_RS22585	COG0673	inositol 2-dehydrogenase activity
Mal52_RS22590	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mal52_RS22595	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Mal52_RS22595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mal52_RS22630	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mal52_RS22680	COG2001	Belongs to the MraZ family
Mal52_RS22685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Mal52_RS22695	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Mal52_RS22705	COG4651	solute:proton antiporter activity
Mal52_RS22705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Mal52_RS22720	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Mal52_RS22745	COG0398	Pfam SNARE associated Golgi protein
Mal52_RS22755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Mal52_RS22760	COG1758	RNA polymerase activity
Mal52_RS22765	COG0194	GDP metabolic process
Mal52_RS22770	COG1561	YicC-like family, N-terminal region
Mal52_RS22780	COG0149	triose-phosphate isomerase activity
Mal52_RS22785	COG0077	Prephenate dehydratase
Mal52_RS22785	COG1605	Chorismate mutase
Mal52_RS22790	COG0443	Heat shock 70 kDa protein
Mal52_RS22795	COG1012	belongs to the aldehyde dehydrogenase family
Mal52_RS22805	COG0628	permease
Mal52_RS22815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mal52_RS22850	COG2234	aminopeptidase activity
Mal52_RS22875	COG0632	four-way junction helicase activity
Mal52_RS22880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Mal52_RS22880	COG0662	Cupin 2, conserved barrel domain protein
Mal52_RS22890	COG0517	IMP dehydrogenase activity
Mal52_RS22890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Mal52_RS22905	COG1164	Oligoendopeptidase f
Mal52_RS22935	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Mal52_RS22940	COG0215	cysteine-tRNA ligase activity
Mal52_RS22945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Mal52_RS22955	COG0174	glutamine synthetase
Mal52_RS22975	COG1725	Transcriptional regulator
Mal52_RS22980	COG1131	(ABC) transporter
Mal52_RS22995	COG0673	inositol 2-dehydrogenase activity
Mal52_RS23010	COG2255	four-way junction helicase activity
Mal52_RS23015	COG0443	Heat shock 70 kDa protein
Mal52_RS23020	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Mal52_RS23030	COG2815	serine threonine protein kinase
Mal52_RS23030	COG0515	serine threonine protein kinase
Mal52_RS23060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mal52_RS23075	COG0154	amidase activity
Mal52_RS23140	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Mal52_RS23145	COG5002	protein histidine kinase activity
Mal52_RS23160	COG0671	phosphoesterase, PA-phosphatase related
Mal52_RS23175	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Mal52_RS23190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Mal52_RS23195	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Mal52_RS23210	COG4109	DRTGG domain
Mal52_RS23215	COG2423	ornithine cyclodeaminase activity
Mal52_RS23220	COG0505	Belongs to the CarA family
Mal52_RS23225	COG0640	Transcriptional regulator
Mal52_RS23235	COG0714	Associated with various cellular activities
Mal52_RS23270	COG2258	MOSC domain
Mal52_RS23295	COG0509	glycine decarboxylation via glycine cleavage system
Mal52_RS23305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Mal52_RS23315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Mal52_RS23320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Mal52_RS23335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Mal52_RS23340	COG0424	maF-like protein
Mal52_RS23345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Mal52_RS23355	COG1690	Belongs to the RtcB family
Mal52_RS23370	COG4232	protein-disulfide reductase activity
Mal52_RS23385	COG0352	thiamine-phosphate diphosphorylase activity
Mal52_RS23390	COG0542	response to heat
Mal52_RS23410	COG2815	serine threonine protein kinase
Mal52_RS23410	COG0515	serine threonine protein kinase
Mal52_RS23415	COG0657	acetylesterase activity
Mal52_RS23415	COG2755	lipolytic protein G-D-S-L family
Mal52_RS23420	COG1752	Esterase of the alpha-beta hydrolase superfamily
Mal52_RS23425	COG1960	acyl-CoA dehydrogenase activity
Mal52_RS23430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Mal52_RS23435	COG0545	Peptidyl-prolyl cis-trans isomerase
Mal52_RS23450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_RS23460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Mal52_RS23465	COG1459	type II secretion system
Mal52_RS23520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Mal52_RS23525	COG0667	Aldo Keto reductase
Mal52_RS23545	COG1587	Uroporphyrinogen-III synthase
Mal52_RS23545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Mal52_RS23555	COG0268	Binds directly to 16S ribosomal RNA
Mal52_RS23570	COG3642	lipopolysaccharide core region biosynthetic process
Mal52_RS23590	COG1078	dGTPase activity
Mal52_RS23595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Mal52_RS23645	COG4974	Belongs to the 'phage' integrase family
Mal52_RS23700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Mal52_RS23720	COG0589	response to stress
Mal52_RS23755	COG0488	(ABC) transporter
Mal52_RS23760	COG1012	belongs to the aldehyde dehydrogenase family
Mal52_RS23775	COG1404	Belongs to the peptidase S8 family
Mal52_RS23805	COG0673	inositol 2-dehydrogenase activity
Mal52_RS23820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Mal52_RS23855	COG2010	Cytochrome c
Mal52_RS23860	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Mal52_RS23865	COG1074	ATP-dependent DNA helicase activity
Mal52_RS23870	COG1122	ATPase activity
Mal52_RS23895	COG0673	inositol 2-dehydrogenase activity
Mal52_RS23905	COG2208	phosphoserine phosphatase activity
Mal52_RS23920	COG1381	Involved in DNA repair and RecF pathway recombination
Mal52_RS23945	COG3119	arylsulfatase activity
Mal52_RS23950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Mal52_RS23975	COG0698	ribose 5-phosphate isomerase
Mal52_RS23995	COG1525	nuclease
Mal52_RS24025	COG0571	ribonuclease III activity
Mal52_RS24065	COG0673	inositol 2-dehydrogenase activity
Mal52_RS24070	COG0589	response to stress
Mal52_RS24095	COG0596	Alpha beta hydrolase
Mal52_RS24145	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Mal52_RS24155	COG1070	Carbohydrate kinase
Mal52_RS24165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Mal52_RS24180	COG1842	Phage shock protein A
Mal52_RS24190	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Mal52_RS24200	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Mal52_RS24295	COG1595	DNA-templated transcription, initiation
Mal52_RS24340	COG2835	tetraacyldisaccharide 4'-kinase activity
Mal52_RS24350	COG0596	Alpha beta hydrolase
Mal52_RS24385	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Mal52_RS24395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Mal52_RS24405	COG0584	glycerophosphoryl diester phosphodiesterase
Mal52_RS24435	COG0802	atpase or kinase
Mal52_RS24440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Mal52_RS24445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_RS24455	COG0471	metal ion transport
Mal52_RS24460	COG0589	response to stress
Mal52_RS24470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Mal52_RS24495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Mal52_RS24530	COG0305	Participates in initiation and elongation during chromosome replication
Mal52_RS24535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Mal52_RS24540	COG0359	binds to the 23S rRNA
Mal52_RS24545	COG0629	single-stranded DNA binding
Mal52_RS24550	COG0360	Binds together with S18 to 16S ribosomal RNA
Mal52_RS24555	COG0193	aminoacyl-tRNA hydrolase activity
Mal52_RS24560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Mal52_RS24635	COG1129	ABC transporter
Mal52_RS24665	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mal52_RS24670	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mal52_RS24670	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Mal52_RS24685	COG2815	serine threonine protein kinase
Mal52_RS24685	COG0515	serine threonine protein kinase
Mal52_RS24690	COG0540	Belongs to the ATCase OTCase family
Mal52_RS24695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Mal52_RS24710	COG4968	Prepilin-type N-terminal cleavage methylation domain
Mal52_RS24735	COG0515	serine threonine protein kinase
Mal52_RS24735	COG2815	serine threonine protein kinase
Mal52_RS24750	COG0606	chelatase, subunit chli
Mal52_RS24765	COG0515	serine threonine protein kinase
Mal52_RS24765	COG2815	serine threonine protein kinase
Mal52_RS24770	COG0628	permease
Mal52_RS24775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mal52_RS24780	COG0601	transmembrane transport
Mal52_RS24785	COG4166	transmembrane transport
Mal52_RS24800	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS24805	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Mal52_RS24830	COG0745	RESPONSE REGULATOR receiver
Mal52_RS24880	COG3963	phosphatidate phosphatase activity
Mal52_RS24895	COG0745	RESPONSE REGULATOR receiver
Mal52_RS24900	COG0006	proline dipeptidase activity
Mal52_RS24915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Mal52_RS24930	COG0515	serine threonine protein kinase
Mal52_RS24930	COG2815	serine threonine protein kinase
Mal52_RS24935	COG0028	Belongs to the TPP enzyme family
Mal52_RS24955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mal52_RS24960	COG0488	(ABC) transporter
Mal52_RS24965	COG0405	Gamma-glutamyltransferase
Mal52_RS25005	COG0657	acetylesterase activity
Mal52_RS25005	COG2755	lipolytic protein G-D-S-L family
Mal52_RS25010	COG1136	(ABC) transporter
Mal52_RS25010	COG0577	efflux transmembrane transporter activity
Mal52_RS25015	COG1136	(ABC) transporter
Mal52_RS25015	COG0577	efflux transmembrane transporter activity
Mal52_RS25045	COG0318	PFAM AMP-dependent synthetase and ligase
Mal52_RS25075	COG1902	pentaerythritol trinitrate reductase activity
Mal52_RS25080	COG0318	PFAM AMP-dependent synthetase and ligase
Mal52_RS25085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mal52_RS25105	COG4145	pantothenate transmembrane transporter activity
Mal52_RS25115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mal52_RS25150	COG3119	arylsulfatase activity
Mal52_RS25155	COG0423	glycine-tRNA ligase activity
Mal52_RS25180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_RS25185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Mal52_RS25195	COG3616	Alanine racemase, N-terminal domain
Mal52_RS25205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_RS25210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_RS25215	COG2995	paraquat-inducible protein a
Mal52_RS25220	COG3008	intermembrane lipid transfer
Mal52_RS25225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Mal52_RS25250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Mal52_RS25270	COG0515	serine threonine protein kinase
Mal52_RS25270	COG2815	serine threonine protein kinase
Mal52_RS25285	COG0483	inositol monophosphate 1-phosphatase activity
Mal52_RS25310	COG1968	undecaprenyl-diphosphatase activity
Mal52_RS25340	COG0745	RESPONSE REGULATOR receiver
Mal52_RS25350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Mal52_RS25365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Mal52_RS25370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Mal52_RS25435	COG1475	DNA binding
Mal52_RS25460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Mal52_RS25515	COG0210	DNA helicase
Mal52_RS25520	COG1111	helicase
Mal52_RS25520	COG1205	dead DEAH box helicase
Mal52_RS25540	COG1309	transcriptional regulator
Mal52_RS25550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mal52_RS25560	COG1752	Esterase of the alpha-beta hydrolase superfamily
Mal52_RS25595	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_RS25620	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Mal52_RS25630	COG0203	ribosomal protein L17
Mal52_RS25635	COG0202	RNA polymerase activity
Mal52_RS25640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Mal52_RS25645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Mal52_RS25650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Mal52_RS25655	COG0024	Methionine aminopeptidase
Mal52_RS25660	COG0201	protein transport
Mal52_RS25670	COG0200	Binds to the 23S rRNA
Mal52_RS25675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Mal52_RS25680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Mal52_RS25685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Mal52_RS25690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Mal52_RS25695	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Mal52_RS25700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Mal52_RS25705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Mal52_RS25710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Mal52_RS25720	COG0255	Belongs to the universal ribosomal protein uL29 family
Mal52_RS25725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Mal52_RS25730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Mal52_RS25735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Mal52_RS25740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Mal52_RS25745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Mal52_RS25750	COG0089	rRNA binding
Mal52_RS25755	COG0088	Forms part of the polypeptide exit tunnel
Mal52_RS25760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Mal52_RS25765	COG0051	transcription antitermination factor activity, RNA binding
Mal52_RS25770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Mal52_RS25775	COG0049	tRNA binding
Mal52_RS25785	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Mal52_RS25790	COG0085	RNA polymerase activity
Mal52_RS25800	COG0222	ribosome binding
Mal52_RS25805	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Mal52_RS25810	COG0081	regulation of translation
Mal52_RS25815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Mal52_RS25835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Mal52_RS25840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mal52_RS25890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mal52_RS25900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Mal52_RS25915	COG0372	Belongs to the citrate synthase family
Mal52_RS25935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Mal52_RS25940	COG0772	Belongs to the SEDS family
Mal52_RS25945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Mal52_RS25950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Mal52_RS25955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Mal52_RS25965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Mal52_RS25970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Mal52_RS25975	COG0706	membrane insertase activity
Mal52_RS25975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_RS25985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Mal52_RS25990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Mal52_RS26000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Mal52_RS26010	COG0714	Associated with various cellular activities
Mal52_RS26020	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Mal52_RS26035	COG3119	arylsulfatase activity
Mal52_RS26045	COG2409	Drug exporters of the RND superfamily
Mal52_RS26050	COG5285	phytanoyl-CoA dioxygenase
Mal52_RS26065	COG0577	efflux transmembrane transporter activity
Mal52_RS26090	COG0784	Response regulator, receiver
Mal52_RS26090	COG2205	protein histidine kinase activity
Mal52_RS26090	COG5002	protein histidine kinase activity
Mal52_RS26110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Mal52_RS26115	COG2878	Part of a membrane complex involved in electron transport
Mal52_RS26160	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Mal52_RS26170	COG0339	signal peptide processing
Mal52_RS26175	COG3458	cephalosporin-C deacetylase activity
Mal52_RS26180	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Mal52_RS26185	COG0726	polysaccharide deacetylase
Mal52_RS26190	COG1473	amidohydrolase
Mal52_RS26195	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Mal52_RS26200	COG0322	excinuclease ABC activity
Mal52_RS26220	COG0300	oxidoreductase activity
Mal52_RS26225	COG0318	PFAM AMP-dependent synthetase and ligase
Mal52_RS26230	COG1796	DNA polymerase
Mal52_RS26230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Mal52_RS26245	COG0415	Belongs to the DNA photolyase family
Mal52_RS26275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Mal52_RS26300	COG2304	oxidoreductase activity
Mal52_RS26305	COG0018	arginyl-trna synthetase
Mal52_RS26310	COG0799	negative regulation of ribosome biogenesis
Mal52_RS26315	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Mal52_RS26330	COG1131	(ABC) transporter
Mal52_RS26350	COG0686	Belongs to the AlaDH PNT family
Mal52_RS26390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Mal52_RS26415	COG1024	Enoyl-CoA hydratase
Mal52_RS26435	COG3119	arylsulfatase activity
Mal52_RS26535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Mal52_RS26540	COG2205	protein histidine kinase activity
Mal52_RS26545	COG0602	queuosine metabolic process
Mal52_RS26550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Mal52_RS26565	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Mal52_RS26585	COG1131	(ABC) transporter
Mal52_RS26610	COG1663	tetraacyldisaccharide 4'-kinase activity
Mal52_RS26625	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Mal52_RS26640	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS26645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Mal52_RS26680	COG1475	DNA binding
Mal52_RS26695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_RS26700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mal52_RS26710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mal52_RS26715	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS26720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mal52_RS26725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mal52_RS26730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mal52_RS26750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Mal52_RS26755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Mal52_RS26800	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Mal52_RS26815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mal52_RS26820	COG0525	valine-tRNA ligase activity
Mal52_RS26830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Mal52_RS26835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Mal52_RS26855	COG2045	Belongs to the ComB family
Mal52_RS26880	COG0242	peptide deformylase activity
Mal52_RS26885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Mal52_RS26910	COG2204	response regulator
Mal52_RS26925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Mal52_RS26935	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Mal52_RS26955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Mal52_RS26955	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Mal52_RS26965	COG0297	glycogen (starch) synthase activity
Mal52_RS26975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Mal52_RS26985	COG1363	Peptidase, m42
Mal52_RS27005	COG0534	Mate efflux family protein
Mal52_RS27015	COG2274	protein secretion by the type I secretion system
Mal52_RS27020	COG0673	inositol 2-dehydrogenase activity
Mal52_RS27030	COG4864	UPF0365 protein
Mal52_RS27060	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Mal52_RS27070	COG0456	acetyltransferase
Mal52_RS27085	COG3119	arylsulfatase activity
Mal52_RS27090	COG0673	inositol 2-dehydrogenase activity
Mal52_RS27100	COG1216	Glycosyl transferase, family 2
Mal52_RS27135	COG1012	belongs to the aldehyde dehydrogenase family
Mal52_RS27145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Mal52_RS27160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Mal52_RS27175	COG0848	biopolymer transport protein
Mal52_RS27180	COG0811	peptide transport
Mal52_RS27185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mal52_RS27185	COG3153	acetyltransferase
Mal52_RS27210	COG1069	ribulokinase activity
Mal52_RS27230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Mal52_RS27235	COG3119	arylsulfatase activity
Mal52_RS27255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mal52_RS27260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mal52_RS27265	COG1566	PFAM secretion protein HlyD family protein
Mal52_RS27270	COG0653	protein targeting
Mal52_RS27275	COG0450	alkyl hydroperoxide reductase
Mal52_RS27295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mal52_RS27300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Mal52_RS27310	COG3706	GGDEF domain
Mal52_RS27315	COG0693	protein deglycase activity
Mal52_RS27320	COG2363	Small membrane protein
Mal52_RS27330	COG0076	glutamate decarboxylase activity
Mal52_RS27380	COG5002	protein histidine kinase activity
Mal52_RS27385	COG1185	polyribonucleotide nucleotidyltransferase activity
Mal52_RS27390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Mal52_RS27395	COG5002	protein histidine kinase activity
Mal52_RS27415	COG0076	glutamate decarboxylase activity
Mal52_RS27420	COG3548	integral membrane protein
Mal52_RS27450	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Mal52_RS27460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Mal52_RS27475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Mal52_RS27485	COG1845	cytochrome c oxidase, subunit III
Mal52_RS27520	COG0069	glutamate synthase activity
Mal52_RS27530	COG0281	malic enzyme
Mal52_RS27535	COG3961	Belongs to the TPP enzyme family
Mal52_RS27540	COG1252	NADH dehydrogenase
Mal52_RS27565	COG2304	oxidoreductase activity
Mal52_RS27585	COG0714	Associated with various cellular activities
Mal52_RS27590	COG2204	response regulator
Mal52_RS27605	COG3118	belongs to the thioredoxin family
Mal52_RS27620	COG0515	serine threonine protein kinase
Mal52_RS27620	COG2815	serine threonine protein kinase
Mal52_RS27630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Mal52_RS27635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mal52_RS27640	COG0730	response to heat
Mal52_RS27710	COG0798	PFAM Bile acid sodium symporter
Mal52_RS27715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Mal52_RS27720	COG0346	lactoylglutathione lyase activity
Mal52_RS27755	COG4864	UPF0365 protein
Mal52_RS27760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Mal52_RS27780	COG1917	Cupin 2, conserved barrel domain protein
Mal52_RS27785	COG5285	phytanoyl-CoA dioxygenase
Mal52_RS27795	COG0006	proline dipeptidase activity
Mal52_RS27805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mal52_RS27810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mal52_RS27815	COG3005	denitrification pathway
Mal52_RS27820	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Mal52_RS27835	COG2267	carboxylic ester hydrolase activity
Mal52_RS27865	COG2815	serine threonine protein kinase
Mal52_RS27865	COG0515	serine threonine protein kinase
Mal52_RS27880	COG0786	glutamate:sodium symporter activity
Mal52_RS27890	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Mal52_RS27895	COG1523	belongs to the glycosyl hydrolase 13 family
Mal52_RS27900	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Mal52_RS27905	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Mal52_RS27925	COG1269	ATP hydrolysis coupled proton transport
Mal52_RS27960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mal52_RS27995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Mal52_RS28055	COG0017	Asparaginyl-tRNA synthetase
Mal52_RS28080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Mal52_RS28085	COG2088	sporulation resulting in formation of a cellular spore
Mal52_RS28105	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Mal52_RS28120	COG0316	Belongs to the HesB IscA family
Mal52_RS28125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Mal52_RS28130	COG4191	Histidine kinase
Mal52_RS28135	COG4566	intracellular signal transduction
Mal52_RS28140	COG0436	Aminotransferase
Mal52_RS28145	COG0133	tryptophan synthase activity
Mal52_RS28170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mal52_RS28190	COG0673	inositol 2-dehydrogenase activity
Mal52_RS28200	COG0515	serine threonine protein kinase
Mal52_RS28200	COG2815	serine threonine protein kinase
Mal52_RS28205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Mal52_RS28215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Mal52_RS28240	COG2017	converts alpha-aldose to the beta-anomer
Mal52_RS28245	COG1678	Uncharacterized ACR, COG1678
Mal52_RS28255	COG0714	Associated with various cellular activities
Mal52_RS28280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Mal52_RS28285	COG2172	sigma factor antagonist activity
Mal52_RS28305	COG2815	serine threonine protein kinase
Mal52_RS28305	COG0515	serine threonine protein kinase
Mal52_RS28325	COG1028	Short-chain dehydrogenase reductase Sdr
Mal52_RS28340	COG1741	Belongs to the pirin family
Mal52_RS28355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mal52_RS28360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_RS28380	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Mal52_RS28415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mal52_RS28465	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Mal52_RS28495	COG4977	sequence-specific DNA binding
Mal52_RS28495	COG1917	Cupin 2, conserved barrel domain protein
Mal52_RS28540	COG0640	Transcriptional regulator
Mal52_RS28605	COG0512	Glutamine amidotransferase of anthranilate synthase
Mal52_RS28615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Mal52_RS28620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Mal52_RS28680	COG2186	Transcriptional regulator
Mal52_RS28785	COG4948	Mandelate Racemase Muconate Lactonizing
Mal52_RS28790	COG2205	protein histidine kinase activity
Mal52_RS28790	COG0745	RESPONSE REGULATOR receiver
Mal52_RS28790	COG4191	Histidine kinase
Mal52_RS28800	COG2046	Belongs to the sulfate adenylyltransferase family
Mal52_RS28820	COG0811	peptide transport
Mal52_RS28825	COG0848	biopolymer transport protein
Mal52_RS28860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mal52_RS28865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Mal52_RS28880	COG0300	oxidoreductase activity
Mal52_RS28885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Mal52_RS28890	COG1607	acyl-coa hydrolase
Mal52_RS28905	COG0024	Methionine aminopeptidase
Mal52_RS28950	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Mal52_RS28960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_RS28965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mal52_RS28990	COG1966	Carbon starvation protein
Mal52_RS29000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mal52_RS29040	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Mal52_RS29045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Mal52_RS29065	COG0545	Peptidyl-prolyl cis-trans isomerase
Mal52_RS29105	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mal52_RS29260	COG1864	DNA RNA non-specific endonuclease
Mal52_RS29260	COG3591	Belongs to the peptidase S1B family
Mal52_RS29275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Mal52_RS29305	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Mal52_RS29310	COG0012	GTP binding
Mal52_RS29325	COG0673	inositol 2-dehydrogenase activity
Mal52_RS29330	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Mal52_RS29335	COG1940	carbohydrate kinase activity
Mal52_RS29350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mal52_RS29375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mal52_RS29380	COG1082	Xylose isomerase domain protein TIM barrel
Mal52_RS29420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Mal52_RS29425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Mal52_RS29430	COG0563	adenylate kinase activity
Mal52_RS29435	COG0758	DNA mediated transformation
Mal52_RS29435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Mal52_RS29440	COG3385	transposase activity
Mal52_RS29455	COG0772	Belongs to the SEDS family
Mal52_RS29460	COG3118	belongs to the thioredoxin family
Mal52_RS29475	COG0052	Belongs to the universal ribosomal protein uS2 family
Mal52_RS29480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Mal52_RS29510	COG1104	cysteine desulfurase activity
Mal52_RS29515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Mal52_RS29520	COG2267	carboxylic ester hydrolase activity
Mal52_RS29540	COG3119	arylsulfatase activity
Mal52_RS29720	COG0384	phenazine biosynthesis protein PhzF
Mal52_RS29820	COG1131	(ABC) transporter
Mal52_RS29845	COG3104	oligopeptide transport
Mal52_RS29860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Mal52_RS29880	COG3339	Conserved Protein
Mal52_RS29925	COG0673	inositol 2-dehydrogenase activity
Mal52_RS29950	COG4566	intracellular signal transduction