locus-tag	class	description
SYC_RS00015	COG1487	ribonuclease activity
SYC_RS00020	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
SYC_RS00035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYC_RS00040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYC_RS00050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SYC_RS00055	COG0613	PHP domain protein
SYC_RS00060	COG0740	serine-type endopeptidase activity
SYC_RS00075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYC_RS00090	COG0110	maltose O-acetyltransferase activity
SYC_RS00105	COG1397	ADP-ribosylglycohydrolase
SYC_RS00135	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SYC_RS00155	COG2217	Heavy metal translocating P-type atpase
SYC_RS00185	COG0038	chloride channel
SYC_RS00190	COG0018	arginyl-trna synthetase
SYC_RS00195	COG0805	protein transport
SYC_RS00215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYC_RS00225	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SYC_RS00235	COG5002	protein histidine kinase activity
SYC_RS00245	COG0038	chloride channel
SYC_RS00260	COG0539	negative regulation of cytoplasmic translation
SYC_RS00270	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYC_RS00275	COG5322	oxidoreductase activity
SYC_RS00280	COG0825	malonyl-CoA metabolic process
SYC_RS00285	COG0300	oxidoreductase activity
SYC_RS00290	COG0302	gtp cyclohydrolase
SYC_RS00295	COG0384	phenazine biosynthesis protein PhzF
SYC_RS00300	COG2385	sporulation resulting in formation of a cellular spore
SYC_RS00310	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SYC_RS00330	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SYC_RS00340	COG0662	Cupin 2, conserved barrel domain protein
SYC_RS00340	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SYC_RS00345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SYC_RS00370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SYC_RS00375	COG0594	ribonuclease P activity
SYC_RS00385	COG0706	membrane insertase activity
SYC_RS00400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYC_RS00405	COG1032	radical SAM domain protein
SYC_RS00410	COG0826	peptidase U32
SYC_RS00450	COG2010	Cytochrome c
SYC_RS00475	COG3659	wide pore channel activity
SYC_RS00480	COG3487	Iron-regulated protein
SYC_RS00495	COG1214	PFAM Peptidase M22, glycoprotease
SYC_RS00510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SYC_RS00515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYC_RS00520	COG0416	fatty acid biosynthetic process
SYC_RS00525	COG0745	RESPONSE REGULATOR receiver
SYC_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SYC_RS00540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYC_RS00545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYC_RS00550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SYC_RS00555	COG0288	reversible hydration of carbon dioxide
SYC_RS00575	COG0191	fructose-bisphosphate aldolase activity
SYC_RS00590	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SYC_RS00595	COG0083	homoserine kinase activity
SYC_RS00600	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYC_RS00620	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SYC_RS00630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SYC_RS00635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYC_RS00635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYC_RS00640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYC_RS00655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SYC_RS00660	COG4451	ribulose bisphosphate carboxylase, small
SYC_RS00665	COG1850	ribulose-bisphosphate carboxylase activity
SYC_RS00670	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYC_RS00675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYC_RS00680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYC_RS00680	COG4451	ribulose bisphosphate carboxylase, small
SYC_RS00685	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
SYC_RS00690	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYC_RS00695	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYC_RS00700	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SYC_RS00715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SYC_RS00720	COG1007	ATP synthesis coupled electron transport
SYC_RS00725	COG1136	(ABC) transporter
SYC_RS00730	COG0730	response to heat
SYC_RS00740	COG0095	Lipoate-protein ligase
SYC_RS00745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYC_RS00750	COG1840	ABC-type Fe3 transport system, periplasmic component
SYC_RS00755	COG4106	trans-aconitate 2-methyltransferase activity
SYC_RS00760	COG1178	ABC-type Fe3 transport system permease component
SYC_RS00765	COG3842	ATPase activity
SYC_RS00780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYC_RS00795	COG2382	esterase
SYC_RS00795	COG3507	Belongs to the glycosyl hydrolase 43 family
SYC_RS00795	COG3693	PFAM glycoside hydrolase, family 10
SYC_RS00830	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYC_RS00835	COG0737	Belongs to the 5'-nucleotidase family
SYC_RS00845	COG0537	adenosine 5'-monophosphoramidase activity
SYC_RS00855	COG3338	carbonate dehydratase activity
SYC_RS00860	COG1606	tRNA processing
SYC_RS00865	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SYC_RS00880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SYC_RS00905	COG0439	Biotin carboxylase
SYC_RS00915	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYC_RS00920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYC_RS00935	COG0564	pseudouridine synthase activity
SYC_RS00945	COG1410	methionine synthase
SYC_RS00945	COG0646	methionine synthase
SYC_RS00950	COG0598	Magnesium transport protein CorA
SYC_RS00960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SYC_RS00970	COG2124	cytochrome p450
SYC_RS00975	COG1575	Belongs to the MenA family. Type 1 subfamily
SYC_RS00980	COG2095	MarC family integral membrane protein
SYC_RS01000	COG1357	PFAM Pentapeptide repeats (8 copies)
SYC_RS01005	COG1316	TRANSCRIPTIONal
SYC_RS01010	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SYC_RS01020	COG4279	zinc finger
SYC_RS01030	COG0784	Response regulator, receiver
SYC_RS01040	COG2814	Major facilitator Superfamily
SYC_RS01050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYC_RS01055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SYC_RS01075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SYC_RS01080	COG0713	ATP synthesis coupled electron transport
SYC_RS01085	COG0839	Belongs to the complex I subunit 6 family
SYC_RS01090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYC_RS01095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SYC_RS01105	COG0628	permease
SYC_RS01110	COG0242	peptide deformylase activity
SYC_RS01145	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SYC_RS01150	COG0602	queuosine metabolic process
SYC_RS01180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SYC_RS01185	COG0305	Participates in initiation and elongation during chromosome replication
SYC_RS01185	COG1372	Participates in initiation and elongation during chromosome replication
SYC_RS01185	COG0305	Participates in initiation and elongation during chromosome replication
SYC_RS01185	COG1372	Participates in initiation and elongation during chromosome replication
SYC_RS01190	COG4581	dead DEAH box helicase
SYC_RS01195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SYC_RS01215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SYC_RS01220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYC_RS01225	COG1121	(ABC) transporter
SYC_RS01230	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYC_RS01235	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SYC_RS01240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYC_RS01245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYC_RS01250	COG1132	(ABC) transporter
SYC_RS01260	COG0583	DNA-binding transcription factor activity
SYC_RS01265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SYC_RS01265	COG0646	methionine synthase
SYC_RS01270	COG0180	Tryptophanyl-tRNA synthetase
SYC_RS01300	COG0589	response to stress
SYC_RS01305	COG0514	ATP-dependent DNA helicase (RecQ)
SYC_RS01310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SYC_RS01315	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYC_RS01320	COG3706	GGDEF domain
SYC_RS01340	COG0515	serine threonine protein kinase
SYC_RS01340	COG1357	PFAM Pentapeptide repeats (8 copies)
SYC_RS01345	COG0072	phenylalanine-tRNA ligase activity
SYC_RS01345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYC_RS01350	COG0358	DNA primase activity
SYC_RS01355	COG0640	Transcriptional regulator
SYC_RS01375	COG0303	'Molybdopterin
SYC_RS01380	COG0315	cyclic pyranopterin monophosphate synthase activity
SYC_RS01380	COG0521	Mo-molybdopterin cofactor biosynthetic process
SYC_RS01390	COG0314	molybdopterin synthase activity
SYC_RS01395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYC_RS01415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SYC_RS01420	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SYC_RS01425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYC_RS01440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SYC_RS01440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SYC_RS01455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYC_RS01460	COG2239	Acts as a magnesium transporter
SYC_RS01465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYC_RS01485	COG0025	NhaP-type Na H and K H
SYC_RS01495	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SYC_RS01500	COG0149	triose-phosphate isomerase activity
SYC_RS01505	COG0501	Belongs to the peptidase M48B family
SYC_RS01510	COG0003	Pfam Anion-transporting ATPase
SYC_RS01520	COG0038	chloride channel
SYC_RS01525	COG0625	glutathione transferase activity
SYC_RS01530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYC_RS01545	COG0420	3'-5' exonuclease activity
SYC_RS01550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SYC_RS01595	COG0583	DNA-binding transcription factor activity
SYC_RS01605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYC_RS01610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYC_RS01615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYC_RS01620	COG1116	anion transmembrane transporter activity
SYC_RS01620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYC_RS01625	COG1116	anion transmembrane transporter activity
SYC_RS01630	COG0243	molybdopterin cofactor binding
SYC_RS01645	COG0723	plastoquinol--plastocyanin reductase activity
SYC_RS01650	COG0739	heme binding
SYC_RS01655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SYC_RS01660	COG2875	Belongs to the precorrin methyltransferase family
SYC_RS01670	COG2003	Belongs to the UPF0758 family
SYC_RS01680	COG0612	Peptidase, M16
SYC_RS01690	COG1566	PFAM secretion protein HlyD family protein
SYC_RS01700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SYC_RS01710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SYC_RS01715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SYC_RS01725	COG4251	negative regulation of phosphorylation
SYC_RS01730	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SYC_RS01740	COG0386	Belongs to the glutathione peroxidase family
SYC_RS01780	COG4115	mRNA cleavage
SYC_RS01790	COG4974	Belongs to the 'phage' integrase family
SYC_RS01810	COG2226	methyltransferase
SYC_RS01820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYC_RS01825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYC_RS01830	COG0134	indole-3-glycerol-phosphate synthase activity
SYC_RS01845	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SYC_RS01860	COG0194	GDP metabolic process
SYC_RS01865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SYC_RS01870	COG0746	molybdenum cofactor guanylyltransferase activity
SYC_RS01905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYC_RS01910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYC_RS01915	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYC_RS01920	COG1773	rubredoxin
SYC_RS01925	COG4447	cellulose binding
SYC_RS01945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SYC_RS01950	COG3046	protein related to deoxyribodipyrimidine photolyase
SYC_RS01955	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SYC_RS01965	COG1691	(AIR) carboxylase
SYC_RS02015	COG5001	Diguanylate cyclase
SYC_RS02020	COG1074	ATP-dependent DNA helicase activity
SYC_RS02035	COG1116	anion transmembrane transporter activity
SYC_RS02040	COG1160	GTP binding
SYC_RS02045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SYC_RS02050	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SYC_RS02050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SYC_RS02065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYC_RS02080	COG0271	Belongs to the BolA IbaG family
SYC_RS02085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SYC_RS02105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYC_RS02125	COG0037	tRNA processing
SYC_RS02155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYC_RS02180	COG0312	modulator of DNA gyrase
SYC_RS02195	COG0557	exoribonuclease II activity
SYC_RS02200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SYC_RS02205	COG0515	serine threonine protein kinase
SYC_RS02205	COG3266	domain, Protein
SYC_RS02210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYC_RS02215	COG0398	Pfam SNARE associated Golgi protein
SYC_RS02220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYC_RS02230	COG0126	phosphoglycerate kinase activity
SYC_RS02235	COG0589	response to stress
SYC_RS02245	COG0628	permease
SYC_RS02250	COG0564	pseudouridine synthase activity
SYC_RS02255	COG0515	serine threonine protein kinase
SYC_RS02255	COG3064	Membrane
SYC_RS02255	COG4991	sh3 domain protein
SYC_RS02265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYC_RS02270	COG0776	regulation of translation
SYC_RS02285	COG0489	protein tyrosine kinase activity
SYC_RS02290	COG0772	Belongs to the SEDS family
SYC_RS02295	COG0363	glucosamine-6-phosphate deaminase activity
SYC_RS02305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYC_RS02310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SYC_RS02315	COG2226	methyltransferase
SYC_RS02320	COG4399	Belongs to the UPF0754 family
SYC_RS02325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SYC_RS02340	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SYC_RS02360	COG0542	response to heat
SYC_RS02365	COG3794	PFAM blue (type 1) copper domain protein
SYC_RS02375	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SYC_RS02380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SYC_RS02390	COG1215	transferase activity, transferring glycosyl groups
SYC_RS02395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYC_RS02400	COG0569	domain protein
SYC_RS02405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SYC_RS02415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SYC_RS02445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SYC_RS02470	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYC_RS02515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SYC_RS02530	COG0352	thiamine-phosphate diphosphorylase activity
SYC_RS02540	COG1413	lyase activity
SYC_RS02545	COG1413	lyase activity
SYC_RS02560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SYC_RS02565	COG0237	dephospho-CoA kinase activity
SYC_RS02570	COG0237	dephospho-CoA kinase activity
SYC_RS02590	COG2385	sporulation resulting in formation of a cellular spore
SYC_RS02600	COG0170	dolichyl monophosphate biosynthetic process
SYC_RS02625	COG1166	arginine decarboxylase activity
SYC_RS02650	COG2308	Evidence 4 Homologs of previously reported genes of
SYC_RS02660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYC_RS02665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYC_RS02670	COG0596	Alpha beta hydrolase
SYC_RS02675	COG2052	Domain of unknown function (DUF370)
SYC_RS02680	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SYC_RS02700	COG0318	PFAM AMP-dependent synthetase and ligase
SYC_RS02705	COG4948	Mandelate Racemase Muconate Lactonizing
SYC_RS02710	COG1640	4-alpha-glucanotransferase
SYC_RS02720	COG0217	transcriptional regulatory protein
SYC_RS02735	COG0840	transmembrane signaling receptor activity
SYC_RS02755	COG0745	RESPONSE REGULATOR receiver
SYC_RS02760	COG5002	protein histidine kinase activity
SYC_RS02765	COG1187	pseudouridine synthase activity
SYC_RS02775	COG0788	formyltetrahydrofolate deformylase activity
SYC_RS02780	COG0114	fumarate hydratase activity
SYC_RS02795	COG1011	Hydrolase
SYC_RS02805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYC_RS02825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYC_RS02830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SYC_RS02835	COG0572	uridine kinase
SYC_RS02850	COG1160	GTP binding
SYC_RS02880	COG0735	belongs to the Fur family
SYC_RS02890	COG2814	Major facilitator Superfamily
SYC_RS02895	COG1381	Involved in DNA repair and RecF pathway recombination
SYC_RS02900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SYC_RS02915	COG1280	lysine exporter protein (LysE YggA)
SYC_RS02930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SYC_RS02935	COG0572	uridine kinase
SYC_RS02940	COG0617	tRNA 3'-terminal CCA addition
SYC_RS02940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SYC_RS02940	COG0517	IMP dehydrogenase activity
SYC_RS02945	COG0275	rRNA processing
SYC_RS02950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SYC_RS02955	COG0251	oxidation-reduction process
SYC_RS02970	COG0412	Dienelactone hydrolase
SYC_RS02980	COG0181	hydroxymethylbilane synthase activity
SYC_RS02990	COG0483	inositol monophosphate 1-phosphatase activity
SYC_RS03005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SYC_RS03005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYC_RS03010	COG1316	TRANSCRIPTIONal
SYC_RS03015	COG3842	ATPase activity
SYC_RS03020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYC_RS03025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SYC_RS03035	COG0523	cobalamin synthesis protein
SYC_RS03045	COG0354	folic acid binding
SYC_RS03060	COG0157	Belongs to the NadC ModD family
SYC_RS03065	COG1653	transport
SYC_RS03080	COG3842	ATPase activity
SYC_RS03085	COG1231	oxidoreductase activity
SYC_RS03095	COG0285	dihydrofolate synthase activity
SYC_RS03100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYC_RS03105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYC_RS03110	COG0488	(ABC) transporter
SYC_RS03120	COG0529	Catalyzes the synthesis of activated sulfate
SYC_RS03130	COG3453	Protein conserved in bacteria
SYC_RS03130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYC_RS03135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SYC_RS03145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYC_RS03155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYC_RS03160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYC_RS03165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYC_RS03170	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SYC_RS03175	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SYC_RS03180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SYC_RS03190	COG0151	Belongs to the GarS family
SYC_RS03195	COG5002	protein histidine kinase activity
SYC_RS03200	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SYC_RS03205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYC_RS03225	COG1022	Amp-dependent synthetase and ligase
SYC_RS03230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SYC_RS03245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SYC_RS03260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYC_RS03275	COG0316	Belongs to the HesB IscA family
SYC_RS03300	COG1049	propionate catabolic process, 2-methylcitrate cycle
SYC_RS03330	COG3411	Ferredoxin
SYC_RS03335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SYC_RS03340	COG2894	cell division
SYC_RS03350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SYC_RS03360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYC_RS03370	COG0070	glutamate synthase
SYC_RS03370	COG0069	glutamate synthase activity
SYC_RS03370	COG0067	glutamate synthase
SYC_RS03385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SYC_RS03390	COG0049	tRNA binding
SYC_RS03395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYC_RS03400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SYC_RS03405	COG0051	transcription antitermination factor activity, RNA binding
SYC_RS03415	COG0077	Prephenate dehydratase
SYC_RS03425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SYC_RS03430	COG1530	ribonuclease E activity
SYC_RS03435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYC_RS03440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SYC_RS03450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYC_RS03480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYC_RS03495	COG1666	GTP binding
SYC_RS03505	COG0857	belongs to the CobB CobQ family
SYC_RS03515	COG0300	oxidoreductase activity
SYC_RS03515	COG3000	fatty acid hydroxylase
SYC_RS03525	COG0643	Histidine kinase
SYC_RS03525	COG2198	Histidine kinase
SYC_RS03525	COG0784	Response regulator, receiver
SYC_RS03530	COG2203	Gaf domain
SYC_RS03530	COG0840	transmembrane signaling receptor activity
SYC_RS03545	COG0784	Response regulator, receiver
SYC_RS03560	COG0436	Aminotransferase
SYC_RS03565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SYC_RS03575	COG1981	membrane
SYC_RS03580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SYC_RS03585	COG2805	Type II/IV secretion system protein
SYC_RS03605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYC_RS03610	COG2072	flavoprotein involved in K transport
SYC_RS03635	COG2144	transferase activity, transferring acyl groups
SYC_RS03640	COG2255	four-way junction helicase activity
SYC_RS03670	COG0017	Asparaginyl-tRNA synthetase
SYC_RS03700	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SYC_RS03700	COG0392	lysyltransferase activity
SYC_RS03705	COG0628	permease
SYC_RS03710	COG0601	transmembrane transport
SYC_RS03715	COG4166	transmembrane transport
SYC_RS03725	COG0047	phosphoribosylformylglycinamidine synthase activity
SYC_RS03730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYC_RS03735	COG0735	belongs to the Fur family
SYC_RS03740	COG5001	Diguanylate cyclase
SYC_RS03740	COG3300	MHYT domain
SYC_RS03750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYC_RS03755	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SYC_RS03760	COG0484	heat shock protein binding
SYC_RS03780	COG0438	transferase activity, transferring glycosyl groups
SYC_RS03790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SYC_RS03800	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SYC_RS03815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SYC_RS03830	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SYC_RS03850	COG1842	Phage shock protein A
SYC_RS03865	COG0617	tRNA 3'-terminal CCA addition
SYC_RS03880	COG0625	glutathione transferase activity
SYC_RS03900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SYC_RS03905	COG1132	(ABC) transporter
SYC_RS03910	COG0574	Belongs to the PEP-utilizing enzyme family
SYC_RS03910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SYC_RS03915	COG1357	PFAM Pentapeptide repeats (8 copies)
SYC_RS03915	COG0515	serine threonine protein kinase
SYC_RS03920	COG1480	7TM receptor with intracellular HD hydrolase
SYC_RS03930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SYC_RS03935	COG0142	geranyltranstransferase activity
SYC_RS03950	COG0454	-acetyltransferase
SYC_RS03965	COG0737	Belongs to the 5'-nucleotidase family
SYC_RS03970	COG2319	Wd-40 repeat
SYC_RS04205	COG1061	Type III restriction enzyme res subunit
SYC_RS04270	COG0582	viral genome integration into host DNA
SYC_RS04280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYC_RS04295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SYC_RS04300	COG0793	Belongs to the peptidase S41A family
SYC_RS04305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYC_RS04320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYC_RS04325	COG1982	Orn Lys Arg decarboxylase major
SYC_RS04345	COG0758	DNA mediated transformation
SYC_RS04345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYC_RS04355	COG0824	Thioesterase
SYC_RS04360	COG0589	response to stress
SYC_RS04385	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYC_RS04390	COG0539	negative regulation of cytoplasmic translation
SYC_RS04410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYC_RS04420	COG0640	Transcriptional regulator
SYC_RS04430	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYC_RS04440	COG0459	protein refolding
SYC_RS04445	COG1028	Short-chain dehydrogenase reductase Sdr
SYC_RS04450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SYC_RS04460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SYC_RS04470	COG0724	RNA recognition motif
SYC_RS04500	COG0408	coproporphyrinogen oxidase activity
SYC_RS04510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYC_RS04520	COG0540	Belongs to the ATCase OTCase family
SYC_RS04525	COG2094	Belongs to the DNA glycosylase MPG family
SYC_RS04545	COG1402	creatininase
SYC_RS04550	COG3264	Mechanosensitive ion channel
SYC_RS04550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SYC_RS04570	COG0287	Prephenate dehydrogenase
SYC_RS04605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYC_RS04615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SYC_RS04625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYC_RS04635	COG1376	ErfK ybiS ycfS ynhG family protein
SYC_RS04645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SYC_RS04650	COG2202	Pas domain
SYC_RS04650	COG2205	protein histidine kinase activity
SYC_RS04660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYC_RS04665	COG1053	succinate dehydrogenase
SYC_RS04670	COG1132	(ABC) transporter
SYC_RS04675	COG0148	phosphopyruvate hydratase activity
SYC_RS04680	COG0346	lactoylglutathione lyase activity
SYC_RS04685	COG0542	response to heat
SYC_RS04690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SYC_RS04695	COG0250	Participates in transcription elongation, termination and antitermination
SYC_RS04700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SYC_RS04705	COG0081	regulation of translation
SYC_RS04710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SYC_RS04715	COG0222	ribosome binding
SYC_RS04730	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SYC_RS04745	COG0129	dihydroxy-acid dehydratase activity
SYC_RS04750	COG3854	ATPases associated with a variety of cellular activities
SYC_RS04760	COG0492	ferredoxin-NADP+ reductase activity
SYC_RS04765	COG4178	(ABC) transporter
SYC_RS04780	COG0586	Pfam SNARE associated Golgi protein
SYC_RS04785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SYC_RS04795	COG1420	regulation of RNA biosynthetic process
SYC_RS04800	COG1054	Belongs to the UPF0176 family
SYC_RS04810	COG2062	phosphohistidine phosphatase, SixA
SYC_RS04815	COG0372	Belongs to the citrate synthase family
SYC_RS04820	COG1193	negative regulation of DNA recombination
SYC_RS04825	COG0668	transmembrane transport
SYC_RS04830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYC_RS04845	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SYC_RS04850	COG3781	membrane
SYC_RS04860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYC_RS04875	COG0515	serine threonine protein kinase
SYC_RS04900	COG2226	methyltransferase
SYC_RS04925	COG0205	6-phosphofructokinase activity
SYC_RS04930	COG2119	membrane
SYC_RS04945	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SYC_RS04950	COG0525	valine-tRNA ligase activity
SYC_RS04980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SYC_RS04985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYC_RS04990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SYC_RS04995	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYC_RS05000	COG0429	hydrolase of the alpha beta-hydrolase fold
SYC_RS05025	COG2022	thiamine diphosphate biosynthetic process
SYC_RS05050	COG0346	lactoylglutathione lyase activity
SYC_RS05055	COG2211	Major facilitator Superfamily
SYC_RS05060	COG0587	DNA-directed DNA polymerase activity
SYC_RS05065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYC_RS05070	COG0402	S-adenosylhomocysteine deaminase activity
SYC_RS05075	COG0277	FAD linked oxidase domain protein
SYC_RS05090	COG1136	(ABC) transporter
SYC_RS05095	COG0556	nucleotide-excision repair
SYC_RS05110	COG1122	ATPase activity
SYC_RS05115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SYC_RS05130	COG0745	RESPONSE REGULATOR receiver
SYC_RS05140	COG0012	GTP binding
SYC_RS05145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYC_RS05165	COG0861	Integral membrane protein TerC family
SYC_RS05180	COG0475	glutathione-regulated potassium exporter activity
SYC_RS05200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYC_RS05225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SYC_RS05230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYC_RS05235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYC_RS05240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYC_RS05245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SYC_RS05265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SYC_RS05270	COG0363	glucosamine-6-phosphate deaminase activity
SYC_RS05285	COG1175	transmembrane transport
SYC_RS05290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SYC_RS05320	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYC_RS05330	COG0628	permease
SYC_RS05335	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYC_RS05335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYC_RS05340	COG0793	Belongs to the peptidase S41A family
SYC_RS05365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYC_RS05380	COG0644	oxidoreductase
SYC_RS05385	COG0233	cytoplasmic translational termination
SYC_RS05390	COG0528	UMP kinase activity
SYC_RS05395	COG1494	fructose-1,6-bisphosphatase
SYC_RS05400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SYC_RS05415	COG0702	epimerase
SYC_RS05430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYC_RS05455	COG0196	riboflavin kinase activity
SYC_RS05465	COG3300	MHYT domain
SYC_RS05465	COG5001	Diguanylate cyclase
SYC_RS05470	COG1012	belongs to the aldehyde dehydrogenase family
SYC_RS05475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SYC_RS05485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SYC_RS05490	COG0406	alpha-ribazole phosphatase activity
SYC_RS05505	COG0768	penicillin binding
SYC_RS05510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYC_RS05520	COG0481	GTPase activity
SYC_RS05525	COG0681	Belongs to the peptidase S26 family
SYC_RS05530	COG0762	integral membrane protein
SYC_RS05535	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYC_RS05545	COG1902	pentaerythritol trinitrate reductase activity
SYC_RS05550	COG1722	exodeoxyribonuclease VII activity
SYC_RS05555	COG0395	ABC-type sugar transport system, permease component
SYC_RS05570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SYC_RS05595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SYC_RS05600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYC_RS05615	COG0456	acetyltransferase
SYC_RS05620	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SYC_RS05635	COG0343	queuine tRNA-ribosyltransferase activity
SYC_RS05640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SYC_RS05645	COG2205	protein histidine kinase activity
SYC_RS05660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SYC_RS05665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SYC_RS05670	COG0750	zinc metalloprotease
SYC_RS05675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SYC_RS05680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SYC_RS05685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SYC_RS05695	COG1361	Conserved repeat domain
SYC_RS05700	COG0004	ammonium transporteR
SYC_RS05705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SYC_RS05710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SYC_RS05715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYC_RS05730	COG1403	HNH endonuclease
SYC_RS05740	COG0701	Predicted permease
SYC_RS05755	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SYC_RS05765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SYC_RS05775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYC_RS05780	COG1131	(ABC) transporter
SYC_RS05810	COG3788	relative of glutathione S-transferase, MAPEG superfamily
SYC_RS05820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYC_RS05865	COG0159	tryptophan synthase activity
SYC_RS05875	COG0135	phosphoribosylanthranilate isomerase activity
SYC_RS05895	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SYC_RS05905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SYC_RS05910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SYC_RS05915	COG0512	Glutamine amidotransferase of anthranilate synthase
SYC_RS05935	COG0138	bifunctional purine biosynthesis protein purh
SYC_RS05945	COG0575	Belongs to the CDS family
SYC_RS05955	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SYC_RS05970	COG0438	transferase activity, transferring glycosyl groups
SYC_RS05975	COG0802	atpase or kinase
SYC_RS05980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SYC_RS05985	COG0644	oxidoreductase
SYC_RS06025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYC_RS06035	COG0612	Peptidase, M16
SYC_RS06040	COG0612	Peptidase, M16
SYC_RS06060	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SYC_RS06070	COG1231	oxidoreductase activity
SYC_RS06080	COG0385	Bile acid
SYC_RS06120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SYC_RS06125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SYC_RS06145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SYC_RS06150	COG1472	Belongs to the glycosyl hydrolase 3 family
SYC_RS06160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYC_RS06170	COG1127	ABC transporter
SYC_RS06180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SYC_RS06185	COG1496	oxidoreductase activity
SYC_RS06190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SYC_RS06190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SYC_RS06220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYC_RS06230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYC_RS06235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SYC_RS06240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYC_RS06245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYC_RS06250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYC_RS06255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYC_RS06260	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYC_RS06265	COG0356	it plays a direct role in the translocation of protons across the membrane
SYC_RS06275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYC_RS06280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYC_RS06300	COG0772	Belongs to the SEDS family
SYC_RS06305	COG4232	protein-disulfide reductase activity
SYC_RS06310	COG1333	cytochrome c biogenesis protein
SYC_RS06315	COG0347	Belongs to the P(II) protein family
SYC_RS06320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYC_RS06325	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SYC_RS06345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SYC_RS06360	COG0792	nuclease activity
SYC_RS06365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SYC_RS06370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SYC_RS06375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYC_RS06385	COG0475	glutathione-regulated potassium exporter activity
SYC_RS06385	COG0589	response to stress
SYC_RS06410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SYC_RS06415	COG0629	single-stranded DNA binding
SYC_RS06420	COG1077	Cell shape determining protein MreB Mrl
SYC_RS06425	COG1792	Involved in formation and maintenance of cell shape
SYC_RS06435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYC_RS06445	COG2046	Belongs to the sulfate adenylyltransferase family
SYC_RS06460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SYC_RS06465	COG3536	Protein conserved in bacteria
SYC_RS06475	COG0167	dihydroorotate dehydrogenase activity
SYC_RS06480	COG0653	protein targeting
SYC_RS06485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SYC_RS06505	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYC_RS06510	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYC_RS06515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYC_RS06520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SYC_RS06525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYC_RS06530	COG1546	Belongs to the CinA family
SYC_RS06530	COG1058	Belongs to the CinA family
SYC_RS06545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYC_RS06550	COG0277	FAD linked oxidase domain protein
SYC_RS06555	COG2361	Protein of unknown function DUF86
SYC_RS06565	COG0237	dephospho-CoA kinase activity
SYC_RS06570	COG1587	Uroporphyrinogen-III synthase
SYC_RS06575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYC_RS06580	COG0463	Glycosyl transferase, family 2
SYC_RS06580	COG0457	Tetratricopeptide repeat
SYC_RS06595	COG0357	Ribosomal RNA small subunit methyltransferase G
SYC_RS06600	COG0484	heat shock protein binding
SYC_RS06610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SYC_RS06615	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SYC_RS06620	COG0019	diaminopimelate decarboxylase activity
SYC_RS06625	COG0456	acetyltransferase
SYC_RS06630	COG0542	response to heat
SYC_RS06645	COG1836	PFAM Integral membrane protein DUF92
SYC_RS06660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYC_RS06685	COG1126	abc transporter atp-binding protein
SYC_RS06690	COG0765	amino acid transport
SYC_RS06695	COG4597	amino acid ABC transporter
SYC_RS06700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYC_RS06705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYC_RS06710	COG0058	SHG alpha-glucan phosphorylase activity
SYC_RS06715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYC_RS06730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SYC_RS06740	COG2010	Cytochrome c
SYC_RS06755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYC_RS06775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SYC_RS06800	COG0193	aminoacyl-tRNA hydrolase activity
SYC_RS06805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYC_RS06830	COG0837	glucose binding
SYC_RS06845	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYC_RS06855	COG0546	phosphoglycolate phosphatase activity
SYC_RS06880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SYC_RS06885	COG1492	cobalamin metabolic process
SYC_RS06895	COG0424	maF-like protein
SYC_RS06915	COG1056	cytidyltransferase-related domain
SYC_RS06915	COG1051	belongs to the nudix hydrolase family
SYC_RS06925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYC_RS06925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYC_RS06930	COG3278	Belongs to the heme-copper respiratory oxidase family
SYC_RS06955	COG2211	Major facilitator Superfamily
SYC_RS06960	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SYC_RS06970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYC_RS06970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYC_RS06985	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SYC_RS06990	COG0519	Catalyzes the synthesis of GMP from XMP
SYC_RS06990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SYC_RS06995	COG1366	Belongs to the anti-sigma-factor antagonist family
SYC_RS07000	COG1253	flavin adenine dinucleotide binding
SYC_RS07010	COG0405	Gamma-glutamyltransferase
SYC_RS07015	COG0306	phosphate transporter
SYC_RS07040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYC_RS07065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SYC_RS07120	COG0799	negative regulation of ribosome biogenesis
SYC_RS07140	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SYC_RS07160	COG0033	Phosphoglucomutase
SYC_RS07180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYC_RS07190	COG0463	Glycosyl transferase, family 2
SYC_RS07195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SYC_RS07225	COG0022	dehydrogenase e1 component
SYC_RS07225	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYC_RS07230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYC_RS07235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYC_RS07245	COG0028	Belongs to the TPP enzyme family
SYC_RS07255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYC_RS07260	COG0582	viral genome integration into host DNA
SYC_RS07265	COG2226	methyltransferase
SYC_RS07300	COG4372	Transposase
SYC_RS07305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYC_RS07310	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SYC_RS07315	COG0131	Imidazoleglycerol-phosphate dehydratase
SYC_RS07320	COG0500	methyltransferase
SYC_RS07330	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SYC_RS07345	COG0590	tRNA wobble adenosine to inosine editing
SYC_RS07355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYC_RS07380	COG0415	Belongs to the DNA photolyase family
SYC_RS07385	COG0443	Heat shock 70 kDa protein
SYC_RS07395	COG0783	Belongs to the Dps family
SYC_RS07405	COG1160	GTP binding
SYC_RS07410	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SYC_RS07415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYC_RS07415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SYC_RS07435	COG1252	NADH dehydrogenase
SYC_RS07450	COG0469	pyruvate kinase activity
SYC_RS07470	COG0745	RESPONSE REGULATOR receiver
SYC_RS07475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYC_RS07480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SYC_RS07495	COG1725	Transcriptional regulator
SYC_RS07500	COG0412	Dienelactone hydrolase
SYC_RS07545	COG1132	(ABC) transporter
SYC_RS07555	COG0577	efflux transmembrane transporter activity
SYC_RS07555	COG1136	(ABC) transporter
SYC_RS07560	COG0629	single-stranded DNA binding
SYC_RS07565	COG0432	Pfam Uncharacterised protein family UPF0047
SYC_RS07580	COG0006	proline dipeptidase activity
SYC_RS07590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SYC_RS07615	COG1131	(ABC) transporter
SYC_RS07630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SYC_RS07640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYC_RS07660	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SYC_RS07700	COG1216	Glycosyl transferase, family 2
SYC_RS07705	COG4969	Belongs to the N-Me-Phe pilin family
SYC_RS07710	COG4969	Belongs to the N-Me-Phe pilin family
SYC_RS07720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYC_RS07740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SYC_RS07745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SYC_RS07750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SYC_RS07755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SYC_RS07760	COG1051	belongs to the nudix hydrolase family
SYC_RS07780	COG2361	Protein of unknown function DUF86
SYC_RS07785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SYC_RS07790	COG4106	trans-aconitate 2-methyltransferase activity
SYC_RS07790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SYC_RS07795	COG4106	trans-aconitate 2-methyltransferase activity
SYC_RS07805	COG0156	8-amino-7-oxononanoate synthase activity
SYC_RS07845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYC_RS07850	COG0751	glycine-tRNA ligase activity
SYC_RS07855	COG0800	Aldolase
SYC_RS07870	COG3128	pkhd-type hydroxylase
SYC_RS07885	COG0360	Binds together with S18 to 16S ribosomal RNA
SYC_RS07895	COG0586	Pfam SNARE associated Golgi protein
SYC_RS07900	COG0137	argininosuccinate synthase activity
SYC_RS07925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYC_RS07930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYC_RS07940	COG0592	DNA-directed DNA polymerase activity
SYC_RS07945	COG0546	phosphoglycolate phosphatase activity
SYC_RS07950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SYC_RS07960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYC_RS07980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SYC_RS07990	COG1845	cytochrome c oxidase, subunit III
SYC_RS08000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SYC_RS08005	COG1612	heme a metabolic process
SYC_RS08010	COG0109	protoheme IX farnesyltransferase activity
SYC_RS08025	COG2954	triphosphatase activity
SYC_RS08030	COG0673	inositol 2-dehydrogenase activity
SYC_RS08035	COG1253	flavin adenine dinucleotide binding
SYC_RS08055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SYC_RS08070	COG2045	Belongs to the ComB family
SYC_RS08075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SYC_RS08090	COG1959	2 iron, 2 sulfur cluster binding
SYC_RS08105	COG0483	inositol monophosphate 1-phosphatase activity
SYC_RS08110	COG0633	Ferredoxin
SYC_RS08120	COG0443	Heat shock 70 kDa protein
SYC_RS08125	COG0484	heat shock protein binding
SYC_RS08135	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SYC_RS08170	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYC_RS08175	COG1121	(ABC) transporter
SYC_RS08180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYC_RS08190	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYC_RS08195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYC_RS08200	COG0284	orotidine-5'-phosphate decarboxylase activity
SYC_RS08210	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SYC_RS08215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYC_RS08220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SYC_RS08225	COG0511	ligase activity, forming carbon-carbon bonds
SYC_RS08230	COG0419	ATPase involved in DNA repair
SYC_RS08235	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SYC_RS08250	COG0359	binds to the 23S rRNA
SYC_RS08255	COG1104	cysteine desulfurase activity
SYC_RS08265	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
SYC_RS08270	COG3259	Nickel-dependent hydrogenase
SYC_RS08280	COG0375	protein maturation
SYC_RS08285	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SYC_RS08290	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SYC_RS08295	COG0298	carbon dioxide binding
SYC_RS08310	COG0066	3-isopropylmalate dehydratase activity
SYC_RS08325	COG0436	Aminotransferase
SYC_RS08335	COG1573	uracil-dna glycosylase
SYC_RS08340	COG2010	Cytochrome c
SYC_RS08355	COG0335	large ribosomal subunit rRNA binding
SYC_RS08365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYC_RS08370	COG0740	serine-type endopeptidase activity
SYC_RS08375	COG0740	serine-type endopeptidase activity
SYC_RS08380	COG0484	heat shock protein binding
SYC_RS08390	COG5001	Diguanylate cyclase
SYC_RS08390	COG4251	negative regulation of phosphorylation
SYC_RS08390	COG3706	GGDEF domain
SYC_RS08390	COG2203	Gaf domain
SYC_RS08405	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SYC_RS08410	COG0052	Belongs to the universal ribosomal protein uS2 family
SYC_RS08425	COG2267	carboxylic ester hydrolase activity
SYC_RS08430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SYC_RS08435	COG0740	serine-type endopeptidase activity
SYC_RS08440	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYC_RS08450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SYC_RS08455	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SYC_RS08470	COG0297	glycogen (starch) synthase activity
SYC_RS08490	COG1074	ATP-dependent DNA helicase activity
SYC_RS08495	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SYC_RS08500	COG0434	BtpA family
SYC_RS08510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYC_RS08520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SYC_RS08530	COG1252	NADH dehydrogenase
SYC_RS08540	COG0175	sulfate reduction
SYC_RS08565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SYC_RS08575	COG2268	Band 7 protein
SYC_RS08585	COG0105	UTP biosynthetic process
SYC_RS08615	COG0187	DNA topoisomerase II activity
SYC_RS08615	COG1372	Participates in initiation and elongation during chromosome replication
SYC_RS08620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYC_RS08655	COG3751	2OG-Fe(II) oxygenase superfamily
SYC_RS08670	COG1090	epimerase
SYC_RS08680	COG0165	Argininosuccinate lyase
SYC_RS08685	COG2208	phosphoserine phosphatase activity
SYC_RS08690	COG0552	protein localization to endoplasmic reticulum
SYC_RS08695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYC_RS08710	COG0443	Heat shock 70 kDa protein
SYC_RS08715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SYC_RS08720	COG0745	RESPONSE REGULATOR receiver
SYC_RS08730	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SYC_RS08735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SYC_RS08740	COG1070	Carbohydrate kinase
SYC_RS08745	COG2957	Belongs to the agmatine deiminase family
SYC_RS08770	COG0752	glycyl-tRNA synthetase alpha subunit
SYC_RS08785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SYC_RS08790	COG0601	transmembrane transport
SYC_RS08820	COG0450	alkyl hydroperoxide reductase
SYC_RS08825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SYC_RS08835	COG0024	Methionine aminopeptidase
SYC_RS08840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYC_RS08845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYC_RS08850	COG0573	inorganic phosphate transmembrane transporter activity
SYC_RS08855	COG0581	inorganic phosphate transmembrane transporter activity
SYC_RS08860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYC_RS08865	COG1185	polyribonucleotide nucleotidyltransferase activity
SYC_RS08885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SYC_RS08890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYC_RS08900	COG0440	acetolactate synthase activity
SYC_RS08905	COG2226	methyltransferase
SYC_RS08905	COG1073	alpha beta
SYC_RS08910	COG4636	protein conserved in cyanobacteria
SYC_RS08925	COG0811	peptide transport
SYC_RS08930	COG0848	biopolymer transport protein
SYC_RS08945	COG0702	epimerase
SYC_RS08955	COG0445	tRNA wobble uridine modification
SYC_RS08965	COG0672	)-iron permease
SYC_RS08970	COG1045	serine acetyltransferase
SYC_RS08980	COG0583	DNA-binding transcription factor activity
SYC_RS08995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SYC_RS09000	COG2226	methyltransferase
SYC_RS09005	COG0330	HflC and HflK could
SYC_RS09020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SYC_RS09035	COG2022	thiamine diphosphate biosynthetic process
SYC_RS09035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYC_RS09040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SYC_RS09060	COG2957	Belongs to the agmatine deiminase family
SYC_RS09065	COG0071	Belongs to the small heat shock protein (HSP20) family
SYC_RS09080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SYC_RS09105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYC_RS09130	COG2140	Oxalate decarboxylase
SYC_RS09140	COG0409	Hydrogenase expression formation protein
SYC_RS09145	COG0167	dihydroorotate dehydrogenase activity
SYC_RS09150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYC_RS09150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SYC_RS09150	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYC_RS09150	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYC_RS09155	COG4956	integral membrane protein (PIN domain superfamily)
SYC_RS09160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYC_RS09165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SYC_RS09175	COG0351	phosphomethylpyrimidine kinase
SYC_RS09180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SYC_RS09195	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYC_RS09200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYC_RS09205	COG4948	Mandelate Racemase Muconate Lactonizing
SYC_RS09215	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYC_RS09250	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SYC_RS09265	COG0142	geranyltranstransferase activity
SYC_RS09270	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SYC_RS09280	COG0475	glutathione-regulated potassium exporter activity
SYC_RS09295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYC_RS09310	COG0321	lipoyl(octanoyl) transferase activity
SYC_RS09315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SYC_RS09320	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SYC_RS09325	COG0009	L-threonylcarbamoyladenylate synthase
SYC_RS09335	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SYC_RS09370	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SYC_RS09375	COG1160	GTP binding
SYC_RS09380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SYC_RS09380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SYC_RS09395	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SYC_RS09400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SYC_RS09405	COG3409	Peptidoglycan-binding domain 1 protein
SYC_RS09405	COG3429	Glucose-6-phosphate dehydrogenase subunit
SYC_RS09410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SYC_RS09415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SYC_RS09420	COG0793	Belongs to the peptidase S41A family
SYC_RS09425	COG1078	dGTPase activity
SYC_RS09450	COG0189	ligase activity
SYC_RS09455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SYC_RS09460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYC_RS09465	COG0457	Tetratricopeptide repeat
SYC_RS09475	COG3093	addiction module antidote protein HigA
SYC_RS09480	COG3224	Antibiotic biosynthesis monooxygenase
SYC_RS09485	COG2217	Heavy metal translocating P-type atpase
SYC_RS09490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SYC_RS09495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SYC_RS09500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYC_RS09505	COG0459	protein refolding
SYC_RS09510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYC_RS09525	COG0076	glutamate decarboxylase activity
SYC_RS09530	COG0450	alkyl hydroperoxide reductase
SYC_RS09535	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYC_RS09545	COG0484	heat shock protein binding
SYC_RS09550	COG0745	RESPONSE REGULATOR receiver
SYC_RS09555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYC_RS09560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SYC_RS09580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SYC_RS09585	COG0632	four-way junction helicase activity
SYC_RS09590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SYC_RS09625	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SYC_RS09630	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SYC_RS09635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SYC_RS09650	COG0371	Dehydrogenase
SYC_RS09655	COG2267	carboxylic ester hydrolase activity
SYC_RS09660	COG1811	Na channel or pump
SYC_RS09665	COG5002	protein histidine kinase activity
SYC_RS09710	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYC_RS09710	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYC_RS09720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SYC_RS09725	COG0494	nUDIX hydrolase
SYC_RS09740	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SYC_RS09755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYC_RS09765	COG0124	histidyl-tRNA synthetase
SYC_RS09785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SYC_RS09790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYC_RS09810	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SYC_RS09815	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SYC_RS09830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SYC_RS09840	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SYC_RS09845	COG0776	regulation of translation
SYC_RS09855	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SYC_RS09870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SYC_RS09880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYC_RS09890	COG0456	acetyltransferase
SYC_RS09900	COG0477	Major facilitator Superfamily
SYC_RS09910	COG4172	Belongs to the ABC transporter superfamily
SYC_RS09915	COG0336	Belongs to the RNA methyltransferase TrmD family
SYC_RS09930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SYC_RS09935	COG0088	Forms part of the polypeptide exit tunnel
SYC_RS09940	COG0089	rRNA binding
SYC_RS09945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SYC_RS09950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SYC_RS09955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SYC_RS09960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SYC_RS09965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SYC_RS09970	COG0255	Belongs to the universal ribosomal protein uL29 family
SYC_RS09975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SYC_RS09980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SYC_RS09985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SYC_RS09990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SYC_RS09995	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SYC_RS10000	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SYC_RS10005	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SYC_RS10010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SYC_RS10015	COG0200	Binds to the 23S rRNA
SYC_RS10020	COG0201	protein transport
SYC_RS10025	COG0563	adenylate kinase activity
SYC_RS10030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SYC_RS10035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SYC_RS10040	COG0202	RNA polymerase activity
SYC_RS10045	COG0203	ribosomal protein L17
SYC_RS10050	COG0101	tRNA pseudouridine synthase activity
SYC_RS10055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SYC_RS10060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SYC_RS10065	COG0254	rRNA binding
SYC_RS10070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYC_RS10080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SYC_RS10095	COG0587	DNA-directed DNA polymerase activity
SYC_RS10105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SYC_RS10125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SYC_RS10130	COG5001	Diguanylate cyclase
SYC_RS10130	COG3300	MHYT domain
SYC_RS10140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYC_RS10165	COG0121	glutamine amidotransferase
SYC_RS10170	COG0328	RNA-DNA hybrid ribonuclease activity
SYC_RS10180	COG0517	IMP dehydrogenase activity
SYC_RS10180	COG1994	Peptidase M50
SYC_RS10185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYC_RS10190	COG1803	Methylglyoxal synthase
SYC_RS10190	COG1597	lipid kinase activity
SYC_RS10195	COG1950	PFAM Membrane protein of
SYC_RS10210	COG1840	ABC-type Fe3 transport system, periplasmic component
SYC_RS10215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYC_RS10230	COG0783	Belongs to the Dps family
SYC_RS10235	COG0735	belongs to the Fur family
SYC_RS10285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SYC_RS10290	COG2267	carboxylic ester hydrolase activity
SYC_RS10305	COG0174	glutamine synthetase
SYC_RS10365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYC_RS10380	COG0133	tryptophan synthase activity
SYC_RS10385	COG0023	Translation Initiation Factor
SYC_RS10405	COG0625	glutathione transferase activity
SYC_RS10420	COG1429	ligase activity, forming nitrogen-metal bonds
SYC_RS10425	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SYC_RS10435	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYC_RS10445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYC_RS10470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYC_RS10490	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYC_RS10495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYC_RS10500	COG0505	Belongs to the CarA family
SYC_RS10510	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SYC_RS10515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYC_RS10525	COG0154	amidase activity
SYC_RS10545	COG2205	protein histidine kinase activity
SYC_RS10550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SYC_RS10560	COG1940	carbohydrate kinase activity
SYC_RS10565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SYC_RS10570	COG1132	(ABC) transporter
SYC_RS10585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYC_RS10590	COG1116	anion transmembrane transporter activity
SYC_RS10595	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SYC_RS10635	COG4251	negative regulation of phosphorylation
SYC_RS10635	COG3706	GGDEF domain
SYC_RS10635	COG5001	Diguanylate cyclase
SYC_RS10635	COG2203	Gaf domain
SYC_RS10645	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SYC_RS10655	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYC_RS10660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYC_RS10665	COG0460	homoserine dehydrogenase
SYC_RS10670	COG4243	Vitamin k epoxide reductase
SYC_RS10680	COG0107	imidazoleglycerol-phosphate synthase activity
SYC_RS10700	COG2095	MarC family integral membrane protein
SYC_RS10705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYC_RS10715	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SYC_RS10720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SYC_RS10735	COG1162	GTPase activity
SYC_RS10745	COG0484	heat shock protein binding
SYC_RS10750	COG0443	Heat shock 70 kDa protein
SYC_RS10755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SYC_RS10760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYC_RS10770	COG1459	type II secretion system
SYC_RS10780	COG2081	HI0933 family
SYC_RS10785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYC_RS10790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SYC_RS10795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYC_RS10800	COG0644	oxidoreductase
SYC_RS10810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SYC_RS10815	COG1799	cell septum assembly
SYC_RS10820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SYC_RS10825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SYC_RS10835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SYC_RS10850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SYC_RS10865	COG2885	chlorophyll binding
SYC_RS10870	COG2885	chlorophyll binding
SYC_RS10875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYC_RS10875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYC_RS10880	COG0509	glycine decarboxylation via glycine cleavage system
SYC_RS10885	COG1196	nuclear chromosome segregation
SYC_RS10895	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SYC_RS10910	COG1489	DNA binding
SYC_RS10940	COG1819	glycosyl
SYC_RS10960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYC_RS10965	COG0166	Belongs to the GPI family
SYC_RS10970	COG0438	transferase activity, transferring glycosyl groups
SYC_RS10975	COG1215	transferase activity, transferring glycosyl groups
SYC_RS10995	COG0779	Required for maturation of 30S ribosomal subunits
SYC_RS11000	COG0195	Participates in both transcription termination and antitermination
SYC_RS11010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYC_RS11040	COG0515	serine threonine protein kinase
SYC_RS11055	COG2385	sporulation resulting in formation of a cellular spore
SYC_RS11060	COG1234	tRNA 3'-trailer cleavage
SYC_RS11065	COG2010	Cytochrome c
SYC_RS11070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SYC_RS11075	COG0426	domain, Protein
SYC_RS11075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYC_RS11080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SYC_RS11095	COG1595	DNA-templated transcription, initiation
SYC_RS11115	COG0850	regulation of cytokinetic process
SYC_RS11125	COG0724	RNA recognition motif
SYC_RS11135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYC_RS11145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SYC_RS11145	COG0140	phosphoribosyl-ATP diphosphatase activity
SYC_RS11150	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SYC_RS11155	COG0235	Class ii aldolase
SYC_RS11160	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYC_RS11165	COG1970	mechanosensitive ion channel activity
SYC_RS11170	COG2119	membrane
SYC_RS11190	COG0612	Peptidase, M16
SYC_RS11195	COG3001	Fructosamine kinase
SYC_RS11200	COG1562	ergosterol biosynthetic process
SYC_RS11205	COG0493	'glutamate synthase
SYC_RS11205	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYC_RS11220	COG0583	DNA-binding transcription factor activity
SYC_RS11230	COG3118	belongs to the thioredoxin family
SYC_RS11235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYC_RS11240	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYC_RS11255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYC_RS11265	COG1473	amidohydrolase
SYC_RS11280	COG1968	undecaprenyl-diphosphatase activity
SYC_RS11300	COG1619	proteins homologs of microcin C7 resistance protein MccF
SYC_RS11310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYC_RS11320	COG0442	prolyl-tRNA aminoacylation
SYC_RS11335	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SYC_RS11340	COG0504	CTP synthase activity
SYC_RS11390	COG0322	excinuclease ABC activity
SYC_RS11395	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SYC_RS11405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYC_RS11410	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SYC_RS11410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYC_RS11420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYC_RS11425	COG0798	PFAM Bile acid sodium symporter
SYC_RS11430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYC_RS11440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SYC_RS11450	COG1304	FMN binding
SYC_RS11470	COG1104	cysteine desulfurase activity
SYC_RS11480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SYC_RS11500	COG1595	DNA-templated transcription, initiation
SYC_RS11515	COG0495	leucyl-tRNA aminoacylation
SYC_RS11530	COG0697	spore germination
SYC_RS11535	COG0616	signal peptide processing
SYC_RS11560	COG0704	Plays a role in the regulation of phosphate uptake
SYC_RS11570	COG0557	exoribonuclease II activity
SYC_RS11575	COG0163	prenyltransferase activity
SYC_RS11590	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYC_RS11595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SYC_RS11625	COG0717	Belongs to the dCTP deaminase family
SYC_RS11635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYC_RS11645	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SYC_RS11665	COG1054	Belongs to the UPF0176 family
SYC_RS11680	COG1543	Belongs to the glycosyl hydrolase 57 family
SYC_RS11695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYC_RS11695	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYC_RS11700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SYC_RS11705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SYC_RS11705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SYC_RS11710	COG0515	serine threonine protein kinase
SYC_RS11715	COG1555	photosystem II stabilization
SYC_RS11720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SYC_RS11730	COG0714	Associated with various cellular activities
SYC_RS11750	COG0312	modulator of DNA gyrase
SYC_RS11755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SYC_RS11765	COG5002	protein histidine kinase activity
SYC_RS11770	COG1566	PFAM secretion protein HlyD family protein
SYC_RS11795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYC_RS11805	COG0009	L-threonylcarbamoyladenylate synthase
SYC_RS11810	COG2890	protein-(glutamine-N5) methyltransferase activity
SYC_RS11825	COG0745	RESPONSE REGULATOR receiver
SYC_RS11835	COG5398	heme oxygenase
SYC_RS11840	COG2084	Dehydrogenase
SYC_RS11850	COG1797	cobyrinic acid a,c-diamide synthase activity
SYC_RS11880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYC_RS11885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SYC_RS11890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SYC_RS11895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SYC_RS11905	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SYC_RS11920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SYC_RS11935	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYC_RS11960	COG1192	Involved in chromosome partitioning
SYC_RS11965	COG0525	valine-tRNA ligase activity
SYC_RS11970	COG0516	GMP reductase activity
SYC_RS11975	COG3118	belongs to the thioredoxin family
SYC_RS11980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SYC_RS12000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SYC_RS12005	COG0516	GMP reductase activity
SYC_RS12005	COG0517	IMP dehydrogenase activity
SYC_RS12020	COG0670	Belongs to the BI1 family
SYC_RS12025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SYC_RS12045	COG0745	RESPONSE REGULATOR receiver
SYC_RS12050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYC_RS12060	COG3447	MASE1 domain protein
SYC_RS12060	COG5002	protein histidine kinase activity
SYC_RS12060	COG5001	Diguanylate cyclase
SYC_RS12065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYC_RS12065	COG0426	domain, Protein
SYC_RS12070	COG0426	domain, Protein
SYC_RS12070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYC_RS12075	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SYC_RS12085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYC_RS12105	COG2197	response regulator
SYC_RS12110	COG0596	Alpha beta hydrolase
SYC_RS12140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SYC_RS12145	COG0436	Aminotransferase
SYC_RS12150	COG3118	belongs to the thioredoxin family
SYC_RS12155	COG0113	porphobilinogen synthase activity
SYC_RS12160	COG2133	pyrroloquinoline quinone binding
SYC_RS12165	COG0338	D12 class N6 adenine-specific DNA methyltransferase
SYC_RS12170	COG0484	heat shock protein binding
SYC_RS12200	COG1615	UPF0182 protein
SYC_RS12205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SYC_RS12210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SYC_RS12215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SYC_RS12220	COG0497	DNA recombination
SYC_RS12225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYC_RS12240	COG1702	phosphate starvation-inducible protein PhoH
SYC_RS12245	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SYC_RS12255	COG0228	four-way junction DNA binding
SYC_RS12260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SYC_RS12280	COG1271	oxidase subunit
SYC_RS12300	COG0483	inositol monophosphate 1-phosphatase activity
SYC_RS12315	COG0686	Belongs to the AlaDH PNT family
SYC_RS12325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SYC_RS12340	COG0456	acetyltransferase
SYC_RS12375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYC_RS12385	COG0824	Thioesterase
SYC_RS12390	COG0649	NAD binding
SYC_RS12395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYC_RS12400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SYC_RS12405	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SYC_RS12415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYC_RS12420	COG0719	Fe-S assembly protein
SYC_RS12425	COG0396	ATPase activity
SYC_RS12430	COG0719	Fe-S assembly protein
SYC_RS12435	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SYC_RS12450	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SYC_RS12460	COG2205	protein histidine kinase activity
SYC_RS12475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SYC_RS12480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SYC_RS12495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SYC_RS12515	COG0538	isocitrate dehydrogenase activity
SYC_RS12520	COG0277	FAD linked oxidase domain protein
SYC_RS12525	COG0247	lactate metabolic process
SYC_RS12535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SYC_RS12540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SYC_RS12570	COG0339	signal peptide processing
SYC_RS12590	COG0383	alpha-mannosidase activity
SYC_RS12605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYC_RS12610	COG0534	Mate efflux family protein
SYC_RS12615	COG1733	regulation of RNA biosynthetic process
SYC_RS12625	COG1741	Belongs to the pirin family
SYC_RS12635	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYC_RS12645	COG1715	Restriction endonuclease
SYC_RS12655	COG2897	thiosulfate sulfurtransferase activity
SYC_RS12660	COG4208	sulfate ABC transporter
SYC_RS12665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SYC_RS12670	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SYC_RS12675	COG4208	sulfate ABC transporter
SYC_RS12680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYC_RS12685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SYC_RS12690	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SYC_RS12695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SYC_RS12700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYC_RS12715	COG2022	thiamine diphosphate biosynthetic process
SYC_RS12715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYC_RS12745	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SYC_RS12750	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SYC_RS12760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SYC_RS12770	COG0673	inositol 2-dehydrogenase activity
SYC_RS12785	COG0215	cysteine-tRNA ligase activity
SYC_RS12795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYC_RS12800	COG0778	Nitroreductase
SYC_RS12815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SYC_RS12830	COG0371	Dehydrogenase
SYC_RS12845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYC_RS12850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYC_RS12850	COG1773	rubredoxin
SYC_RS12870	COG0571	ribonuclease III activity
SYC_RS12880	COG2203	Gaf domain
SYC_RS12880	COG4251	negative regulation of phosphorylation
SYC_RS12880	COG3706	GGDEF domain
SYC_RS12880	COG5001	Diguanylate cyclase
SYC_RS12895	COG3688	RNA-binding protein containing a PIN domain
SYC_RS12900	COG1122	ATPase activity
SYC_RS12915	COG2154	pterin-4-alpha-carbinolamine dehydratase
SYC_RS12920	COG3659	wide pore channel activity
SYC_RS12925	COG3659	wide pore channel activity
SYC_RS12930	COG1959	2 iron, 2 sulfur cluster binding
SYC_RS12935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYC_RS12940	COG0484	heat shock protein binding
SYC_RS12965	COG0651	ATP synthesis coupled electron transport
SYC_RS12970	COG1006	Multisubunit Na H antiporter MnhC subunit
SYC_RS12980	COG0347	Belongs to the P(II) protein family
SYC_RS12990	COG2010	Cytochrome c
SYC_RS13000	COG0742	ribosomal rna small subunit methyltransferase
SYC_RS13005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SYC_RS13020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYC_RS13030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SYC_RS13035	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SYC_RS13040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYC_RS13045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYC_RS13050	COG1116	anion transmembrane transporter activity
SYC_RS13050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYC_RS13055	COG1116	anion transmembrane transporter activity
SYC_RS13065	COG3956	TIGRFAM MazG family protein
SYC_RS13080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SYC_RS13095	COG0633	Ferredoxin
SYC_RS13100	COG2264	protein methyltransferase activity
SYC_RS13105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SYC_RS13125	COG0473	3-isopropylmalate dehydrogenase activity
SYC_RS13140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYC_RS13150	COG0482	sulfurtransferase activity
SYC_RS13155	COG1191	sigma factor activity
SYC_RS13165	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYC_RS13170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SYC_RS13175	COG1187	pseudouridine synthase activity
SYC_RS13190	COG5002	protein histidine kinase activity
SYC_RS13200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SYC_RS13205	COG0268	Binds directly to 16S ribosomal RNA
SYC_RS13210	COG0084	hydrolase, TatD family'
SYC_RS13215	COG0085	RNA polymerase activity
SYC_RS13220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYC_RS13225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYC_RS13240	COG3604	Transcriptional regulator
SYC_RS13260	COG0725	ABC transporter, periplasmic molybdate-binding protein
SYC_RS13265	COG4149	molybdate abc transporter
SYC_RS13300	COG0716	FMN binding
SYC_RS13385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein