locus-tag	class	description
BRW62_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BRW62_RS00025	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BRW62_RS00045	COG0830	nickel cation binding
BRW62_RS00050	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BRW62_RS00080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRW62_RS00110	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BRW62_RS00115	COG5322	oxidoreductase activity
BRW62_RS00120	COG0825	malonyl-CoA metabolic process
BRW62_RS00125	COG0300	oxidoreductase activity
BRW62_RS00130	COG0302	gtp cyclohydrolase
BRW62_RS00135	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRW62_RS00145	COG0745	RESPONSE REGULATOR receiver
BRW62_RS00160	COG0473	3-isopropylmalate dehydrogenase activity
BRW62_RS00165	COG0248	Ppx GppA phosphatase
BRW62_RS00170	COG2326	polyphosphate kinase activity
BRW62_RS00180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BRW62_RS00215	COG0305	Participates in initiation and elongation during chromosome replication
BRW62_RS00215	COG0305	Participates in initiation and elongation during chromosome replication
BRW62_RS00215	COG1372	Participates in initiation and elongation during chromosome replication
BRW62_RS00215	COG1372	Participates in initiation and elongation during chromosome replication
BRW62_RS00220	COG0359	binds to the 23S rRNA
BRW62_RS00245	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BRW62_RS00255	COG2957	Belongs to the agmatine deiminase family
BRW62_RS00260	COG0254	rRNA binding
BRW62_RS00265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BRW62_RS00270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BRW62_RS00275	COG0101	tRNA pseudouridine synthase activity
BRW62_RS00280	COG0203	ribosomal protein L17
BRW62_RS00285	COG0202	RNA polymerase activity
BRW62_RS00290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BRW62_RS00295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BRW62_RS00300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BRW62_RS00305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BRW62_RS00310	COG0563	adenylate kinase activity
BRW62_RS00315	COG0201	protein transport
BRW62_RS00320	COG0200	Binds to the 23S rRNA
BRW62_RS00325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BRW62_RS00330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BRW62_RS00335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BRW62_RS00340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BRW62_RS00345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BRW62_RS00350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BRW62_RS00355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BRW62_RS00360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRW62_RS00365	COG0255	Belongs to the universal ribosomal protein uL29 family
BRW62_RS00370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRW62_RS00375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BRW62_RS00380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BRW62_RS00385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BRW62_RS00390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BRW62_RS00395	COG0089	rRNA binding
BRW62_RS00400	COG0088	Forms part of the polypeptide exit tunnel
BRW62_RS00405	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BRW62_RS00410	COG0343	queuine tRNA-ribosyltransferase activity
BRW62_RS00420	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRW62_RS00425	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BRW62_RS00445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BRW62_RS00455	COG0745	RESPONSE REGULATOR receiver
BRW62_RS00475	COG1530	ribonuclease E activity
BRW62_RS00505	COG0095	Lipoate-protein ligase
BRW62_RS00520	COG4783	chaperone-mediated protein folding
BRW62_RS00525	COG1657	PFAM Prenyltransferase squalene oxidase
BRW62_RS00550	COG1070	Carbohydrate kinase
BRW62_RS00555	COG0442	prolyl-tRNA aminoacylation
BRW62_RS00560	COG0114	fumarate hydratase activity
BRW62_RS00565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRW62_RS00575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BRW62_RS00590	COG0575	Belongs to the CDS family
BRW62_RS00595	COG0022	dehydrogenase e1 component
BRW62_RS00595	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRW62_RS00600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRW62_RS00605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRW62_RS00630	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BRW62_RS00635	COG0612	Peptidase, M16
BRW62_RS00640	COG5001	Diguanylate cyclase
BRW62_RS00650	COG0516	GMP reductase activity
BRW62_RS00650	COG0517	IMP dehydrogenase activity
BRW62_RS00660	COG0616	signal peptide processing
BRW62_RS00665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BRW62_RS00670	COG0670	Belongs to the BI1 family
BRW62_RS00680	COG0316	Belongs to the HesB IscA family
BRW62_RS00735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BRW62_RS00740	COG0628	permease
BRW62_RS00755	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRW62_RS00765	COG0438	transferase activity, transferring glycosyl groups
BRW62_RS00770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRW62_RS00785	COG0784	Response regulator, receiver
BRW62_RS00805	COG0643	Histidine kinase
BRW62_RS00805	COG0784	Response regulator, receiver
BRW62_RS00805	COG2198	Histidine kinase
BRW62_RS00815	COG1091	dTDP-4-dehydrorhamnose reductase activity
BRW62_RS00845	COG0590	tRNA wobble adenosine to inosine editing
BRW62_RS00855	COG0612	Peptidase, M16
BRW62_RS00865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BRW62_RS00870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BRW62_RS00885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BRW62_RS00910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BRW62_RS00940	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BRW62_RS00945	COG4399	Belongs to the UPF0754 family
BRW62_RS00955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BRW62_RS00960	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BRW62_RS00965	COG0739	heme binding
BRW62_RS00970	COG0805	protein transport
BRW62_RS00990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRW62_RS01020	COG0217	transcriptional regulatory protein
BRW62_RS01050	COG0702	epimerase
BRW62_RS01075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BRW62_RS01080	COG0443	Heat shock 70 kDa protein
BRW62_RS01095	COG2205	protein histidine kinase activity
BRW62_RS01120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRW62_RS01125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRW62_RS01135	COG1357	PFAM Pentapeptide repeats (8 copies)
BRW62_RS01135	COG0515	serine threonine protein kinase
BRW62_RS01155	COG0704	Plays a role in the regulation of phosphate uptake
BRW62_RS01160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BRW62_RS01165	COG0793	Belongs to the peptidase S41A family
BRW62_RS01195	COG0857	belongs to the CobB CobQ family
BRW62_RS01235	COG3631	Ketosteroid isomerase-related protein
BRW62_RS01260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BRW62_RS01265	COG0215	cysteine-tRNA ligase activity
BRW62_RS01270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BRW62_RS01275	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BRW62_RS01290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BRW62_RS01295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BRW62_RS01325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BRW62_RS01340	COG0631	protein serine/threonine phosphatase activity
BRW62_RS01345	COG4251	negative regulation of phosphorylation
BRW62_RS01355	COG1489	DNA binding
BRW62_RS01360	COG1773	rubredoxin
BRW62_RS01365	COG4447	cellulose binding
BRW62_RS01370	COG0745	RESPONSE REGULATOR receiver
BRW62_RS01400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRW62_RS01405	COG0730	response to heat
BRW62_RS01450	COG1366	Belongs to the anti-sigma-factor antagonist family
BRW62_RS01465	COG0024	Methionine aminopeptidase
BRW62_RS01485	COG0697	spore germination
BRW62_RS01490	COG0109	protoheme IX farnesyltransferase activity
BRW62_RS01510	COG0629	single-stranded DNA binding
BRW62_RS01535	COG3980	spore coat polysaccharide biosynthesis protein
BRW62_RS01545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRW62_RS01550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRW62_RS01560	COG1970	mechanosensitive ion channel activity
BRW62_RS01565	COG0740	serine-type endopeptidase activity
BRW62_RS01575	COG0019	diaminopimelate decarboxylase activity
BRW62_RS01580	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BRW62_RS01585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BRW62_RS01615	COG1049	propionate catabolic process, 2-methylcitrate cycle
BRW62_RS01660	COG0686	Belongs to the AlaDH PNT family
BRW62_RS01665	COG0077	Prephenate dehydratase
BRW62_RS01670	COG0842	Transport permease protein
BRW62_RS01670	COG1131	(ABC) transporter
BRW62_RS01670	COG1716	ATPase activity
BRW62_RS01690	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BRW62_RS01695	COG0746	molybdenum cofactor guanylyltransferase activity
BRW62_RS01695	COG0315	cyclic pyranopterin monophosphate synthase activity
BRW62_RS01700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRW62_RS01705	COG0314	molybdopterin synthase activity
BRW62_RS01715	COG0347	Belongs to the P(II) protein family
BRW62_RS01740	COG0716	FMN binding
BRW62_RS01750	COG1899	peptidyl-lysine modification to peptidyl-hypusine
BRW62_RS01755	COG1121	(ABC) transporter
BRW62_RS01765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRW62_RS01790	COG0303	'Molybdopterin
BRW62_RS01795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRW62_RS01805	COG1137	ATPase activity
BRW62_RS01825	COG0484	heat shock protein binding
BRW62_RS01835	COG0505	Belongs to the CarA family
BRW62_RS01840	COG0602	queuosine metabolic process
BRW62_RS01855	COG0237	dephospho-CoA kinase activity
BRW62_RS01870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRW62_RS01895	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BRW62_RS01900	COG0649	NAD binding
BRW62_RS01905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BRW62_RS01915	COG2010	Cytochrome c
BRW62_RS01920	COG2010	Cytochrome c
BRW62_RS01930	COG0070	glutamate synthase
BRW62_RS01930	COG0069	glutamate synthase activity
BRW62_RS01930	COG0067	glutamate synthase
BRW62_RS01935	COG0134	indole-3-glycerol-phosphate synthase activity
BRW62_RS01940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRW62_RS01950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRW62_RS01965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRW62_RS02020	COG0438	transferase activity, transferring glycosyl groups
BRW62_RS02040	COG0438	transferase activity, transferring glycosyl groups
BRW62_RS02075	COG0367	asparagine synthase
BRW62_RS02100	COG0489	protein tyrosine kinase activity
BRW62_RS02105	COG0523	cobalamin synthesis protein
BRW62_RS02180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRW62_RS02190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRW62_RS02215	COG0242	peptide deformylase activity
BRW62_RS02225	COG0509	glycine decarboxylation via glycine cleavage system
BRW62_RS02240	COG4243	Vitamin k epoxide reductase
BRW62_RS02270	COG3842	ATPase activity
BRW62_RS02275	COG0142	geranyltranstransferase activity
BRW62_RS02280	COG0681	Belongs to the peptidase S26 family
BRW62_RS02290	COG1968	undecaprenyl-diphosphatase activity
BRW62_RS02295	COG1191	sigma factor activity
BRW62_RS02305	COG0297	glycogen (starch) synthase activity
BRW62_RS02310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BRW62_RS02320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRW62_RS02330	COG2226	methyltransferase
BRW62_RS02350	COG0148	phosphopyruvate hydratase activity
BRW62_RS02355	COG0058	SHG alpha-glucan phosphorylase activity
BRW62_RS02360	COG2223	nitrite transmembrane transporter activity
BRW62_RS02365	COG2217	Heavy metal translocating P-type atpase
BRW62_RS02370	COG3781	membrane
BRW62_RS02380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRW62_RS02400	COG5002	protein histidine kinase activity
BRW62_RS02405	COG2203	Gaf domain
BRW62_RS02405	COG3706	GGDEF domain
BRW62_RS02405	COG5001	Diguanylate cyclase
BRW62_RS02405	COG4251	negative regulation of phosphorylation
BRW62_RS02425	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BRW62_RS02425	COG0617	tRNA 3'-terminal CCA addition
BRW62_RS02425	COG0517	IMP dehydrogenase activity
BRW62_RS02440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BRW62_RS02450	COG1492	cobalamin metabolic process
BRW62_RS02460	COG2385	sporulation resulting in formation of a cellular spore
BRW62_RS02475	COG0583	DNA-binding transcription factor activity
BRW62_RS02505	COG1666	GTP binding
BRW62_RS02520	COG0484	heat shock protein binding
BRW62_RS02540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRW62_RS02545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BRW62_RS02555	COG0728	peptidoglycan biosynthetic process
BRW62_RS02560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BRW62_RS02565	COG5002	protein histidine kinase activity
BRW62_RS02570	COG0601	transmembrane transport
BRW62_RS02575	COG0717	Belongs to the dCTP deaminase family
BRW62_RS02585	COG0519	Catalyzes the synthesis of GMP from XMP
BRW62_RS02585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRW62_RS02605	COG0310	cobalt ion transport
BRW62_RS02610	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
BRW62_RS02620	COG1122	ATPase activity
BRW62_RS02630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BRW62_RS02635	COG0419	ATPase involved in DNA repair
BRW62_RS02675	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BRW62_RS02685	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BRW62_RS02695	COG1131	(ABC) transporter
BRW62_RS02695	COG0842	Transport permease protein
BRW62_RS02695	COG1716	ATPase activity
BRW62_RS02700	COG0459	protein refolding
BRW62_RS02715	COG1595	DNA-templated transcription, initiation
BRW62_RS02735	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRW62_RS02740	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRW62_RS02750	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRW62_RS02765	COG0497	DNA recombination
BRW62_RS02775	COG1131	(ABC) transporter
BRW62_RS02780	COG1083	cytidylyl-transferase
BRW62_RS02790	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
BRW62_RS02800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BRW62_RS02820	COG1799	cell septum assembly
BRW62_RS02830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRW62_RS02850	COG0387	Pfam Sodium calcium exchanger
BRW62_RS02865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRW62_RS02875	COG3158	transport of potassium into the cell
BRW62_RS02880	COG1333	cytochrome c biogenesis protein
BRW62_RS02885	COG0408	coproporphyrinogen oxidase activity
BRW62_RS02895	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BRW62_RS02900	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BRW62_RS02915	COG0443	Heat shock 70 kDa protein
BRW62_RS02920	COG4572	Cation transport regulator
BRW62_RS02925	COG0484	heat shock protein binding
BRW62_RS02930	COG0789	Transcriptional regulator
BRW62_RS02945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BRW62_RS02955	COG0537	adenosine 5'-monophosphoramidase activity
BRW62_RS02970	COG0559	Belongs to the binding-protein-dependent transport system permease family
BRW62_RS03000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRW62_RS03010	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BRW62_RS03015	COG0750	zinc metalloprotease
BRW62_RS03020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRW62_RS03050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BRW62_RS03070	COG0174	glutamine synthetase
BRW62_RS03080	COG0540	Belongs to the ATCase OTCase family
BRW62_RS03095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRW62_RS03095	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BRW62_RS03100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRW62_RS03115	COG2217	Heavy metal translocating P-type atpase
BRW62_RS03145	COG0675	Transposase, IS605 OrfB family
BRW62_RS03155	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BRW62_RS03180	COG2082	Precorrin-8x methylmutase
BRW62_RS03200	COG1959	2 iron, 2 sulfur cluster binding
BRW62_RS03210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BRW62_RS03215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BRW62_RS03235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BRW62_RS03245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BRW62_RS03245	COG0438	transferase activity, transferring glycosyl groups
BRW62_RS03250	COG2211	Major facilitator Superfamily
BRW62_RS03255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRW62_RS03265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BRW62_RS03280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BRW62_RS03290	COG0572	uridine kinase
BRW62_RS03300	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BRW62_RS03315	COG0440	acetolactate synthase activity
BRW62_RS03325	COG4221	oxidoreductase activity
BRW62_RS03365	COG1131	(ABC) transporter
BRW62_RS03370	COG0517	IMP dehydrogenase activity
BRW62_RS03370	COG1994	Peptidase M50
BRW62_RS03385	COG0457	Tetratricopeptide repeat
BRW62_RS03385	COG0463	Glycosyl transferase, family 2
BRW62_RS03390	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BRW62_RS03400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BRW62_RS03415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BRW62_RS03435	COG0003	Pfam Anion-transporting ATPase
BRW62_RS03440	COG0742	ribosomal rna small subunit methyltransferase
BRW62_RS03445	COG1528	Iron-storage protein
BRW62_RS03475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BRW62_RS03480	COG0625	glutathione transferase activity
BRW62_RS03490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRW62_RS03490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRW62_RS03500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BRW62_RS03510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BRW62_RS03515	COG1132	(ABC) transporter
BRW62_RS03530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BRW62_RS03545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BRW62_RS03550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BRW62_RS03560	COG1121	(ABC) transporter
BRW62_RS03565	COG0617	tRNA 3'-terminal CCA addition
BRW62_RS03580	COG0137	argininosuccinate synthase activity
BRW62_RS03585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRW62_RS03600	COG0189	ligase activity
BRW62_RS03600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BRW62_RS03615	COG1116	anion transmembrane transporter activity
BRW62_RS03620	COG1116	anion transmembrane transporter activity
BRW62_RS03625	COG1366	Belongs to the anti-sigma-factor antagonist family
BRW62_RS03630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRW62_RS03630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRW62_RS03655	COG0287	Prephenate dehydrogenase
BRW62_RS03670	COG0515	serine threonine protein kinase
BRW62_RS03675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRW62_RS03690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRW62_RS03695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BRW62_RS03705	COG1217	gtp-binding protein TYPA
BRW62_RS03715	COG0735	belongs to the Fur family
BRW62_RS03745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BRW62_RS03750	COG1959	2 iron, 2 sulfur cluster binding
BRW62_RS03760	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BRW62_RS03765	COG2894	cell division
BRW62_RS03775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BRW62_RS03780	COG0581	inorganic phosphate transmembrane transporter activity
BRW62_RS03785	COG0573	inorganic phosphate transmembrane transporter activity
BRW62_RS03790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRW62_RS03810	COG0574	Belongs to the PEP-utilizing enzyme family
BRW62_RS03810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRW62_RS03815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRW62_RS03820	COG0811	peptide transport
BRW62_RS03835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRW62_RS03840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BRW62_RS03845	COG0463	Glycosyl transferase, family 2
BRW62_RS03845	COG0457	Tetratricopeptide repeat
BRW62_RS03850	COG0469	pyruvate kinase activity
BRW62_RS03865	COG0135	phosphoribosylanthranilate isomerase activity
BRW62_RS03900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BRW62_RS03910	COG0783	Belongs to the Dps family
BRW62_RS03915	COG0789	Transcriptional regulator
BRW62_RS03920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BRW62_RS03930	COG3706	GGDEF domain
BRW62_RS03935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRW62_RS03950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BRW62_RS03955	COG2203	Gaf domain
BRW62_RS03955	COG5001	Diguanylate cyclase
BRW62_RS03955	COG3706	GGDEF domain
BRW62_RS03955	COG4251	negative regulation of phosphorylation
BRW62_RS03960	COG1799	cell septum assembly
BRW62_RS03965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BRW62_RS03975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRW62_RS03980	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BRW62_RS03990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BRW62_RS03995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BRW62_RS04000	COG1331	Highly conserved protein containing a thioredoxin domain
BRW62_RS04005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BRW62_RS04015	COG1252	NADH dehydrogenase
BRW62_RS04040	COG0051	transcription antitermination factor activity, RNA binding
BRW62_RS04045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BRW62_RS04050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BRW62_RS04055	COG0049	tRNA binding
BRW62_RS04060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRW62_RS04065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRW62_RS04070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRW62_RS04080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BRW62_RS04090	COG1606	tRNA processing
BRW62_RS04095	COG0557	exoribonuclease II activity
BRW62_RS04120	COG0429	hydrolase of the alpha beta-hydrolase fold
BRW62_RS04130	COG0515	serine threonine protein kinase
BRW62_RS04150	COG0501	Belongs to the peptidase M48B family
BRW62_RS04165	COG0515	serine threonine protein kinase
BRW62_RS04165	COG1357	PFAM Pentapeptide repeats (8 copies)
BRW62_RS04185	COG1012	belongs to the aldehyde dehydrogenase family
BRW62_RS04195	COG3932	Exopolysaccharide synthesis, ExoD
BRW62_RS04210	COG0693	protein deglycase activity
BRW62_RS04230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BRW62_RS04240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRW62_RS04245	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BRW62_RS04250	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BRW62_RS04255	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
BRW62_RS04260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRW62_RS04260	COG4451	ribulose bisphosphate carboxylase, small
BRW62_RS04265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRW62_RS04280	COG2081	HI0933 family
BRW62_RS04295	COG0735	belongs to the Fur family
BRW62_RS04305	COG1619	proteins homologs of microcin C7 resistance protein MccF
BRW62_RS04320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRW62_RS04325	COG1615	UPF0182 protein
BRW62_RS04330	COG0596	Alpha beta hydrolase
BRW62_RS04335	COG0271	Belongs to the BolA IbaG family
BRW62_RS04340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRW62_RS04345	COG0071	Belongs to the small heat shock protein (HSP20) family
BRW62_RS04370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRW62_RS04385	COG0157	Belongs to the NadC ModD family
BRW62_RS04390	COG1178	ABC-type Fe3 transport system permease component
BRW62_RS04425	COG1842	Phage shock protein A
BRW62_RS04430	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BRW62_RS04440	COG0837	glucose binding
BRW62_RS04445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BRW62_RS04450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRW62_RS04455	COG3527	Alpha-acetolactate decarboxylase
BRW62_RS04460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRW62_RS04480	COG0328	RNA-DNA hybrid ribonuclease activity
BRW62_RS04500	COG0768	penicillin binding
BRW62_RS04505	COG0181	hydroxymethylbilane synthase activity
BRW62_RS04515	COG1122	ATPase activity
BRW62_RS04520	COG0438	transferase activity, transferring glycosyl groups
BRW62_RS04525	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BRW62_RS04530	COG1012	belongs to the aldehyde dehydrogenase family
BRW62_RS04535	COG1543	Belongs to the glycosyl hydrolase 57 family
BRW62_RS04540	COG4178	(ABC) transporter
BRW62_RS04570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BRW62_RS04580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRW62_RS04585	COG0454	-acetyltransferase
BRW62_RS04595	COG3956	TIGRFAM MazG family protein
BRW62_RS04610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRW62_RS04620	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BRW62_RS04620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRW62_RS04625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BRW62_RS04630	COG0052	Belongs to the universal ribosomal protein uS2 family
BRW62_RS04635	COG2211	Major facilitator Superfamily
BRW62_RS04640	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
BRW62_RS04665	COG0745	RESPONSE REGULATOR receiver
BRW62_RS04680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BRW62_RS04685	COG0740	serine-type endopeptidase activity
BRW62_RS04690	COG0544	peptidyl-prolyl cis-trans isomerase activity
BRW62_RS04695	COG1834	amidinotransferase
BRW62_RS04715	COG1473	amidohydrolase
BRW62_RS04740	COG0798	PFAM Bile acid sodium symporter
BRW62_RS04745	COG0436	Aminotransferase
BRW62_RS04750	COG4279	zinc finger
BRW62_RS04755	COG1361	Conserved repeat domain
BRW62_RS04770	COG1063	alcohol dehydrogenase
BRW62_RS04780	COG0519	Catalyzes the synthesis of GMP from XMP
BRW62_RS04780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRW62_RS04785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRW62_RS04790	COG0187	DNA topoisomerase II activity
BRW62_RS04790	COG1372	Participates in initiation and elongation during chromosome replication
BRW62_RS04795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BRW62_RS04800	COG0204	Acyl-transferase
BRW62_RS04800	COG0318	PFAM AMP-dependent synthetase and ligase
BRW62_RS04805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRW62_RS04815	COG1007	ATP synthesis coupled electron transport
BRW62_RS04830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW62_RS04835	COG1073	alpha beta
BRW62_RS04840	COG0552	protein localization to endoplasmic reticulum
BRW62_RS04845	COG0436	Aminotransferase
BRW62_RS04850	COG0481	GTPase activity
BRW62_RS04860	COG0033	Phosphoglucomutase
BRW62_RS04865	COG0420	3'-5' exonuclease activity
BRW62_RS04880	COG0405	Gamma-glutamyltransferase
BRW62_RS04890	COG0396	ATPase activity
BRW62_RS04895	COG0719	Fe-S assembly protein
BRW62_RS04925	COG0720	synthase
BRW62_RS04945	COG0483	inositol monophosphate 1-phosphatase activity
BRW62_RS04950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BRW62_RS04960	COG0170	dolichyl monophosphate biosynthetic process
BRW62_RS04965	COG0824	Thioesterase
BRW62_RS04980	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BRW62_RS04995	COG1058	Belongs to the CinA family
BRW62_RS04995	COG1546	Belongs to the CinA family
BRW62_RS05000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRW62_RS05005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BRW62_RS05010	COG2203	Gaf domain
BRW62_RS05010	COG3706	GGDEF domain
BRW62_RS05010	COG4251	negative regulation of phosphorylation
BRW62_RS05010	COG5001	Diguanylate cyclase
BRW62_RS05015	COG0701	Predicted permease
BRW62_RS05020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BRW62_RS05040	COG0193	aminoacyl-tRNA hydrolase activity
BRW62_RS05045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRW62_RS05075	COG0436	Aminotransferase
BRW62_RS05080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BRW62_RS05085	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
BRW62_RS05100	COG2264	protein methyltransferase activity
BRW62_RS05105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRW62_RS05125	COG1216	Glycosyl transferase, family 2
BRW62_RS05145	COG2154	pterin-4-alpha-carbinolamine dehydratase
BRW62_RS05155	COG0228	four-way junction DNA binding
BRW62_RS05160	COG1837	Belongs to the UPF0109 family
BRW62_RS05165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BRW62_RS05170	COG1702	phosphate starvation-inducible protein PhoH
BRW62_RS05185	COG0151	Belongs to the GarS family
BRW62_RS05195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRW62_RS05205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRW62_RS05210	COG0557	exoribonuclease II activity
BRW62_RS05220	COG0336	Belongs to the RNA methyltransferase TrmD family
BRW62_RS05225	COG0616	signal peptide processing
BRW62_RS05235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRW62_RS05240	COG0793	Belongs to the peptidase S41A family
BRW62_RS05250	COG0028	Belongs to the TPP enzyme family
BRW62_RS05255	COG5505	Protein of unknown function (DUF819)
BRW62_RS05270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BRW62_RS05280	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BRW62_RS05285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BRW62_RS05290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BRW62_RS05295	COG0588	phosphoglycerate mutase activity
BRW62_RS05300	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRW62_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
BRW62_RS05335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BRW62_RS05345	COG0714	Associated with various cellular activities
BRW62_RS05360	COG1187	pseudouridine synthase activity
BRW62_RS05370	COG2890	protein-(glutamine-N5) methyltransferase activity
BRW62_RS05400	COG0470	DNA polymerase III
BRW62_RS05405	COG0066	3-isopropylmalate dehydratase activity
BRW62_RS05420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BRW62_RS05425	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
BRW62_RS05435	COG0512	Glutamine amidotransferase of anthranilate synthase
BRW62_RS05440	COG0745	RESPONSE REGULATOR receiver
BRW62_RS05455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BRW62_RS05465	COG0004	ammonium transporteR
BRW62_RS05470	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BRW62_RS05485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BRW62_RS05495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRW62_RS05510	COG0133	tryptophan synthase activity
BRW62_RS05515	COG0475	glutathione-regulated potassium exporter activity
BRW62_RS05515	COG0589	response to stress
BRW62_RS05520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRW62_RS05525	COG4636	protein conserved in cyanobacteria
BRW62_RS05540	COG0732	type I restriction modification DNA specificity domain
BRW62_RS05585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BRW62_RS05605	COG2226	methyltransferase
BRW62_RS05610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRW62_RS05620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRW62_RS05630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW62_RS05645	COG3536	Protein conserved in bacteria
BRW62_RS05650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRW62_RS05655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BRW62_RS05660	COG0438	transferase activity, transferring glycosyl groups
BRW62_RS05675	COG1132	(ABC) transporter
BRW62_RS05680	COG2815	serine threonine protein kinase
BRW62_RS05680	COG0515	serine threonine protein kinase
BRW62_RS05690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRW62_RS05700	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BRW62_RS05705	COG1446	asparaginase
BRW62_RS05725	COG1640	4-alpha-glucanotransferase
BRW62_RS05735	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BRW62_RS05745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BRW62_RS05750	COG0714	Associated with various cellular activities
BRW62_RS05765	COG0484	heat shock protein binding
BRW62_RS05770	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BRW62_RS05780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BRW62_RS05785	COG1132	(ABC) transporter
BRW62_RS05790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BRW62_RS05810	COG0719	Fe-S assembly protein
BRW62_RS05820	COG1073	alpha beta
BRW62_RS05820	COG2226	methyltransferase
BRW62_RS05825	COG2046	Belongs to the sulfate adenylyltransferase family
BRW62_RS05840	COG1472	Belongs to the glycosyl hydrolase 3 family
BRW62_RS05845	COG1253	flavin adenine dinucleotide binding
BRW62_RS05865	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BRW62_RS05870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BRW62_RS05875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BRW62_RS05910	COG3659	wide pore channel activity
BRW62_RS05915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BRW62_RS05925	COG2304	oxidoreductase activity
BRW62_RS05935	COG0149	triose-phosphate isomerase activity
BRW62_RS05945	COG1192	Involved in chromosome partitioning
BRW62_RS05985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRW62_RS05990	COG0037	tRNA processing
BRW62_RS05995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BRW62_RS06010	COG4208	sulfate ABC transporter
BRW62_RS06015	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BRW62_RS06020	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRW62_RS06040	COG0596	Alpha beta hydrolase
BRW62_RS06045	COG0275	rRNA processing
BRW62_RS06050	COG0012	GTP binding
BRW62_RS06055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BRW62_RS06060	COG0776	regulation of translation
BRW62_RS06065	COG0126	phosphoglycerate kinase activity
BRW62_RS06070	COG0589	response to stress
BRW62_RS06145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BRW62_RS06150	COG0741	lytic transglycosylase activity
BRW62_RS06150	COG0791	NLP P60 protein
BRW62_RS06155	COG0516	GMP reductase activity
BRW62_RS06170	COG1185	polyribonucleotide nucleotidyltransferase activity
BRW62_RS06180	COG1733	regulation of RNA biosynthetic process
BRW62_RS06185	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BRW62_RS06190	COG5398	heme oxygenase
BRW62_RS06195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRW62_RS06215	COG0233	cytoplasmic translational termination
BRW62_RS06220	COG0528	UMP kinase activity
BRW62_RS06235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BRW62_RS06235	COG0512	Glutamine amidotransferase of anthranilate synthase
BRW62_RS06240	COG3118	belongs to the thioredoxin family
BRW62_RS06255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRW62_RS06260	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BRW62_RS06275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BRW62_RS06280	COG2205	protein histidine kinase activity
BRW62_RS06285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BRW62_RS06300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BRW62_RS06305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BRW62_RS06310	COG0741	lytic transglycosylase activity
BRW62_RS06325	COG1940	carbohydrate kinase activity
BRW62_RS06355	COG1716	ATPase activity
BRW62_RS06360	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BRW62_RS06370	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BRW62_RS06380	COG0592	DNA-directed DNA polymerase activity
BRW62_RS06385	COG0530	calcium, potassium:sodium antiporter activity
BRW62_RS06390	COG0675	Transposase, IS605 OrfB family
BRW62_RS06400	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BRW62_RS06405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BRW62_RS06420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BRW62_RS06425	COG1842	Phage shock protein A
BRW62_RS06430	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BRW62_RS06440	COG2954	triphosphatase activity
BRW62_RS06445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRW62_RS06485	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BRW62_RS06490	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BRW62_RS06505	COG0589	response to stress
BRW62_RS06510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BRW62_RS06520	COG0628	permease
BRW62_RS06525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BRW62_RS06530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BRW62_RS06550	COG0659	secondary active sulfate transmembrane transporter activity
BRW62_RS06555	COG2094	Belongs to the DNA glycosylase MPG family
BRW62_RS06565	COG0484	heat shock protein binding
BRW62_RS06580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRW62_RS06580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRW62_RS06600	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRW62_RS06610	COG1840	ABC-type Fe3 transport system, periplasmic component
BRW62_RS06615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BRW62_RS06630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BRW62_RS06630	COG0140	phosphoribosyl-ATP diphosphatase activity
BRW62_RS06640	COG1218	3'(2'),5'-bisphosphate nucleotidase
BRW62_RS06645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BRW62_RS06655	COG0556	nucleotide-excision repair
BRW62_RS06665	COG0006	proline dipeptidase activity
BRW62_RS06670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BRW62_RS06680	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BRW62_RS06680	COG3264	Mechanosensitive ion channel
BRW62_RS06690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRW62_RS06695	COG0321	lipoyl(octanoyl) transferase activity
BRW62_RS06700	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BRW62_RS06705	COG5002	protein histidine kinase activity
BRW62_RS06705	COG5002	protein histidine kinase activity
BRW62_RS06710	COG2204	response regulator
BRW62_RS06730	COG0793	Belongs to the peptidase S41A family
BRW62_RS06735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRW62_RS06740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BRW62_RS06760	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRW62_RS06780	COG1136	(ABC) transporter
BRW62_RS06780	COG0577	efflux transmembrane transporter activity
BRW62_RS06795	COG0489	protein tyrosine kinase activity
BRW62_RS06800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BRW62_RS06810	COG0138	bifunctional purine biosynthesis protein purh
BRW62_RS06815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRW62_RS06820	COG1175	transmembrane transport
BRW62_RS06865	COG0175	sulfate reduction
BRW62_RS06870	COG0752	glycyl-tRNA synthetase alpha subunit
BRW62_RS06890	COG1122	ATPase activity
BRW62_RS06905	COG1022	Amp-dependent synthetase and ligase
BRW62_RS06910	COG0424	maF-like protein
BRW62_RS06915	COG0335	large ribosomal subunit rRNA binding
BRW62_RS06935	COG0277	FAD linked oxidase domain protein
BRW62_RS06945	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BRW62_RS06950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRW62_RS06965	COG0085	RNA polymerase activity
BRW62_RS06970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BRW62_RS06975	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BRW62_RS06990	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BRW62_RS06995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRW62_RS07000	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRW62_RS07005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BRW62_RS07015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BRW62_RS07020	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BRW62_RS07030	COG0277	FAD linked oxidase domain protein
BRW62_RS07035	COG0247	lactate metabolic process
BRW62_RS07040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BRW62_RS07050	COG0511	ligase activity, forming carbon-carbon bonds
BRW62_RS07050	COG0511	ligase activity, forming carbon-carbon bonds
BRW62_RS07055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BRW62_RS07060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BRW62_RS07070	COG0457	Tetratricopeptide repeat
BRW62_RS07075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BRW62_RS07090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BRW62_RS07100	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BRW62_RS07140	COG1376	ErfK ybiS ycfS ynhG family protein
BRW62_RS07150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BRW62_RS07165	COG0724	RNA recognition motif
BRW62_RS07175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRW62_RS07205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BRW62_RS07215	COG0542	response to heat
BRW62_RS07230	COG5001	Diguanylate cyclase
BRW62_RS07240	COG0583	DNA-binding transcription factor activity
BRW62_RS07245	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BRW62_RS07255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRW62_RS07270	COG0675	Transposase, IS605 OrfB family
BRW62_RS07275	COG2385	sporulation resulting in formation of a cellular spore
BRW62_RS07280	COG1587	Uroporphyrinogen-III synthase
BRW62_RS07310	COG1754	DNA topoisomerase type I activity
BRW62_RS07310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BRW62_RS07315	COG3118	belongs to the thioredoxin family
BRW62_RS07325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BRW62_RS07330	COG2197	response regulator
BRW62_RS07335	COG1716	ATPase activity
BRW62_RS07335	COG1131	(ABC) transporter
BRW62_RS07335	COG0842	Transport permease protein
BRW62_RS07355	COG0251	oxidation-reduction process
BRW62_RS07360	COG2885	chlorophyll binding
BRW62_RS07365	COG2885	chlorophyll binding
BRW62_RS07370	COG4636	protein conserved in cyanobacteria
BRW62_RS07380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BRW62_RS07385	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BRW62_RS07405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BRW62_RS07415	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BRW62_RS07420	COG0745	RESPONSE REGULATOR receiver
BRW62_RS07425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRW62_RS07440	COG0205	6-phosphofructokinase activity
BRW62_RS07450	COG1215	transferase activity, transferring glycosyl groups
BRW62_RS07455	COG0535	radical SAM domain protein
BRW62_RS07465	COG0653	protein targeting
BRW62_RS07470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BRW62_RS07470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BRW62_RS07480	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BRW62_RS07495	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRW62_RS07500	COG0360	Binds together with S18 to 16S ribosomal RNA
BRW62_RS07515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BRW62_RS07525	COG0284	orotidine-5'-phosphate decarboxylase activity
BRW62_RS07540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BRW62_RS07545	COG1672	PFAM Archaeal ATPase
BRW62_RS07550	COG2814	Major facilitator Superfamily
BRW62_RS07555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRW62_RS07585	COG0156	8-amino-7-oxononanoate synthase activity
BRW62_RS07595	COG0745	RESPONSE REGULATOR receiver
BRW62_RS07610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRW62_RS07675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRW62_RS07690	COG0800	Aldolase
BRW62_RS07700	COG0747	negative chemotaxis
BRW62_RS07710	COG3118	belongs to the thioredoxin family
BRW62_RS07715	COG2062	phosphohistidine phosphatase, SixA
BRW62_RS07735	COG0484	heat shock protein binding
BRW62_RS07740	COG1459	type II secretion system
BRW62_RS07750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRW62_RS07760	COG1192	Involved in chromosome partitioning
BRW62_RS07765	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BRW62_RS07775	COG1376	ErfK ybiS ycfS ynhG family protein
BRW62_RS07795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRW62_RS07800	COG0316	Belongs to the HesB IscA family
BRW62_RS07835	COG0799	negative regulation of ribosome biogenesis
BRW62_RS07840	COG3596	GTP binding
BRW62_RS07865	COG0831	urea catabolic process
BRW62_RS07870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BRW62_RS07880	COG2268	Band 7 protein
BRW62_RS07890	COG0804	urea catabolic process
BRW62_RS07895	COG0792	nuclease activity
BRW62_RS07900	COG0492	ferredoxin-NADP+ reductase activity
BRW62_RS07905	COG0730	response to heat
BRW62_RS07915	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BRW62_RS07925	COG0656	L-ascorbic acid biosynthetic process
BRW62_RS07945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRW62_RS07955	COG0285	dihydrofolate synthase activity
BRW62_RS07965	COG0004	ammonium transporteR
BRW62_RS07975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BRW62_RS07980	COG0459	protein refolding
BRW62_RS08000	COG1104	cysteine desulfurase activity
BRW62_RS08010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BRW62_RS08025	COG1132	(ABC) transporter
BRW62_RS08035	COG1271	oxidase subunit
BRW62_RS08040	COG1294	oxidase, subunit
BRW62_RS08050	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BRW62_RS08055	COG1850	ribulose-bisphosphate carboxylase activity
BRW62_RS08065	COG4451	ribulose bisphosphate carboxylase, small
BRW62_RS08080	COG1136	(ABC) transporter
BRW62_RS08100	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRW62_RS08105	COG0539	negative regulation of cytoplasmic translation
BRW62_RS08160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BRW62_RS08170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BRW62_RS08180	COG0195	Participates in both transcription termination and antitermination
BRW62_RS08185	COG0779	Required for maturation of 30S ribosomal subunits
BRW62_RS08205	COG3854	ATPases associated with a variety of cellular activities
BRW62_RS08215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRW62_RS08220	COG1716	ATPase activity
BRW62_RS08220	COG5001	Diguanylate cyclase
BRW62_RS08230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BRW62_RS08240	COG0573	inorganic phosphate transmembrane transporter activity
BRW62_RS08245	COG0581	inorganic phosphate transmembrane transporter activity
BRW62_RS08250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BRW62_RS08260	COG0363	glucosamine-6-phosphate deaminase activity
BRW62_RS08280	COG0675	Transposase, IS605 OrfB family
BRW62_RS08340	COG3659	wide pore channel activity
BRW62_RS08345	COG2197	response regulator
BRW62_RS08410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BRW62_RS08425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRW62_RS08440	COG0457	Tetratricopeptide repeat
BRW62_RS08445	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRW62_RS08450	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BRW62_RS08455	COG1496	oxidoreductase activity
BRW62_RS08470	COG1797	cobyrinic acid a,c-diamide synthase activity
BRW62_RS08480	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
BRW62_RS08490	COG0740	serine-type endopeptidase activity
BRW62_RS08500	COG0163	prenyltransferase activity
BRW62_RS08520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRW62_RS08530	COG2202	Pas domain
BRW62_RS08530	COG2205	protein histidine kinase activity
BRW62_RS08535	COG0495	leucyl-tRNA aminoacylation
BRW62_RS08545	COG0840	transmembrane signaling receptor activity
BRW62_RS08555	COG0835	chemotaxis
BRW62_RS08575	COG2201	protein-glutamate methylesterase activity
BRW62_RS08595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRW62_RS08605	COG0525	valine-tRNA ligase activity
BRW62_RS08610	COG1028	Short-chain dehydrogenase reductase Sdr
BRW62_RS08630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BRW62_RS08660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRW62_RS08670	COG0039	L-malate dehydrogenase activity
BRW62_RS08680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BRW62_RS08710	COG2308	Evidence 4 Homologs of previously reported genes of
BRW62_RS08715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRW62_RS08745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BRW62_RS08765	COG2022	thiamine diphosphate biosynthetic process
BRW62_RS08780	COG1214	PFAM Peptidase M22, glycoprotease
BRW62_RS08780	COG0456	acetyltransferase
BRW62_RS08790	COG0420	3'-5' exonuclease activity
BRW62_RS08825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRW62_RS08835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BRW62_RS08840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BRW62_RS08855	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BRW62_RS08860	COG0612	Peptidase, M16
BRW62_RS08865	COG1716	ATPase activity
BRW62_RS08865	COG5001	Diguanylate cyclase
BRW62_RS08870	COG0789	Transcriptional regulator
BRW62_RS08910	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRW62_RS08915	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BRW62_RS08930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRW62_RS08930	COG0646	methionine synthase
BRW62_RS08945	COG2205	protein histidine kinase activity
BRW62_RS08945	COG0784	Response regulator, receiver
BRW62_RS08945	COG5002	protein histidine kinase activity
BRW62_RS08950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRW62_RS08950	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BRW62_RS08955	COG1192	Involved in chromosome partitioning
BRW62_RS08965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRW62_RS08985	COG0482	sulfurtransferase activity
BRW62_RS08990	COG0724	RNA recognition motif
BRW62_RS08995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BRW62_RS09000	COG2255	four-way junction helicase activity
BRW62_RS09005	COG2204	response regulator
BRW62_RS09020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRW62_RS09035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BRW62_RS09045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BRW62_RS09050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BRW62_RS09065	COG3411	Ferredoxin
BRW62_RS09070	COG3842	ATPase activity
BRW62_RS09095	COG1741	Belongs to the pirin family
BRW62_RS09115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BRW62_RS09120	COG0312	modulator of DNA gyrase
BRW62_RS09155	COG0460	homoserine dehydrogenase
BRW62_RS09165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRW62_RS09170	COG2052	Domain of unknown function (DUF370)
BRW62_RS09175	COG0484	heat shock protein binding
BRW62_RS09180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRW62_RS09185	COG0484	heat shock protein binding
BRW62_RS09190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BRW62_RS09195	COG0515	serine threonine protein kinase
BRW62_RS09195	COG1357	PFAM Pentapeptide repeats (8 copies)
BRW62_RS09210	COG1473	amidohydrolase
BRW62_RS09230	COG4372	Transposase
BRW62_RS09240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BRW62_RS09260	COG1162	GTPase activity
BRW62_RS09270	COG0582	viral genome integration into host DNA
BRW62_RS09310	COG1166	arginine decarboxylase activity
BRW62_RS09325	COG0445	tRNA wobble uridine modification
BRW62_RS09330	COG0829	nickel cation binding
BRW62_RS09355	COG0483	inositol monophosphate 1-phosphatase activity
BRW62_RS09360	COG0017	Asparaginyl-tRNA synthetase
BRW62_RS09365	COG1193	negative regulation of DNA recombination
BRW62_RS09385	COG0569	domain protein
BRW62_RS09410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRW62_RS09415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRW62_RS09420	COG1305	Transglutaminase-like
BRW62_RS09440	COG0165	Argininosuccinate lyase
BRW62_RS09445	COG5398	heme oxygenase
BRW62_RS09515	COG0784	Response regulator, receiver
BRW62_RS09515	COG2205	protein histidine kinase activity
BRW62_RS09515	COG5002	protein histidine kinase activity
BRW62_RS09520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRW62_RS09525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRW62_RS09530	COG0339	signal peptide processing
BRW62_RS09540	COG1792	Involved in formation and maintenance of cell shape
BRW62_RS09550	COG1132	(ABC) transporter
BRW62_RS09600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRW62_RS09610	COG1304	FMN binding
BRW62_RS09620	COG0121	glutamine amidotransferase
BRW62_RS09630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BRW62_RS09635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BRW62_RS09640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BRW62_RS09640	COG1116	anion transmembrane transporter activity
BRW62_RS09645	COG1116	anion transmembrane transporter activity
BRW62_RS09650	COG0243	molybdopterin cofactor binding
BRW62_RS09655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BRW62_RS09665	COG0848	biopolymer transport protein
BRW62_RS09680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRW62_RS09685	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW62_RS09695	COG0484	heat shock protein binding
BRW62_RS09700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BRW62_RS09700	COG0426	domain, Protein
BRW62_RS09705	COG0426	domain, Protein
BRW62_RS09705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BRW62_RS09710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BRW62_RS09715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BRW62_RS09715	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BRW62_RS09730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRW62_RS09755	COG0515	serine threonine protein kinase
BRW62_RS09755	COG1357	PFAM Pentapeptide repeats (8 copies)
BRW62_RS09760	COG1429	ligase activity, forming nitrogen-metal bonds
BRW62_RS09770	COG2048	Heterodisulfide reductase, subunit B
BRW62_RS09775	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BRW62_RS09785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BRW62_RS09795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRW62_RS09795	COG0574	Belongs to the PEP-utilizing enzyme family
BRW62_RS09800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRW62_RS09805	COG1555	photosystem II stabilization
BRW62_RS09810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BRW62_RS09815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BRW62_RS09835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BRW62_RS09840	COG2852	Protein conserved in bacteria
BRW62_RS09890	COG1285	pathogenesis
BRW62_RS09905	COG0189	ligase activity
BRW62_RS09910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BRW62_RS09920	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW62_RS09955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BRW62_RS09960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRW62_RS09965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BRW62_RS09970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRW62_RS09975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BRW62_RS09980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BRW62_RS09985	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BRW62_RS09990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BRW62_RS09995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BRW62_RS10025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRW62_RS10040	COG2217	Heavy metal translocating P-type atpase
BRW62_RS10045	COG1836	PFAM Integral membrane protein DUF92
BRW62_RS10050	COG0463	Glycosyl transferase, family 2
BRW62_RS10055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRW62_RS10065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRW62_RS10075	COG0839	Belongs to the complex I subunit 6 family
BRW62_RS10080	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW62_RS10085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BRW62_RS10090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRW62_RS10105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRW62_RS10120	COG0668	transmembrane transport
BRW62_RS10125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BRW62_RS10130	COG0450	alkyl hydroperoxide reductase
BRW62_RS10150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRW62_RS10170	COG0514	ATP-dependent DNA helicase (RecQ)
BRW62_RS10175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BRW62_RS10210	COG0357	Ribosomal RNA small subunit methyltransferase G
BRW62_RS10220	COG0739	heme binding
BRW62_RS10245	COG0772	Belongs to the SEDS family
BRW62_RS10250	COG0159	tryptophan synthase activity
BRW62_RS10255	COG2831	hemolysin activation secretion protein
BRW62_RS10265	COG5002	protein histidine kinase activity
BRW62_RS10270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRW62_RS10275	COG1420	regulation of RNA biosynthetic process
BRW62_RS10315	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BRW62_RS10320	COG0358	DNA primase activity
BRW62_RS10330	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BRW62_RS10335	COG0084	hydrolase, TatD family'
BRW62_RS10340	COG0268	Binds directly to 16S ribosomal RNA
BRW62_RS10355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BRW62_RS10365	COG0113	porphobilinogen synthase activity
BRW62_RS10370	COG0431	NADPH-dependent FMN reductase
BRW62_RS10380	COG0484	heat shock protein binding
BRW62_RS10385	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRW62_RS10400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BRW62_RS10405	COG1122	ATPase activity
BRW62_RS10415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BRW62_RS10420	COG0850	regulation of cytokinetic process
BRW62_RS10430	COG0515	serine threonine protein kinase
BRW62_RS10445	COG2003	Belongs to the UPF0758 family
BRW62_RS10450	COG3659	wide pore channel activity
BRW62_RS10455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BRW62_RS10460	COG0297	glycogen (starch) synthase activity
BRW62_RS10470	COG1441	menaquinone biosynthetic process
BRW62_RS10480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRW62_RS10490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRW62_RS10490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRW62_RS10500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRW62_RS10515	COG0456	acetyltransferase
BRW62_RS10525	COG1575	Belongs to the MenA family. Type 1 subfamily
BRW62_RS10550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BRW62_RS10560	COG2217	Heavy metal translocating P-type atpase
BRW62_RS10565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRW62_RS10575	COG0154	amidase activity
BRW62_RS10585	COG2319	Wd-40 repeat
BRW62_RS10585	COG1672	PFAM Archaeal ATPase
BRW62_RS10610	COG0768	penicillin binding
BRW62_RS10620	COG0275	rRNA processing
BRW62_RS10635	COG0352	thiamine-phosphate diphosphorylase activity
BRW62_RS10640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRW62_RS10655	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BRW62_RS10670	COG0107	imidazoleglycerol-phosphate synthase activity
BRW62_RS10675	COG0632	four-way junction helicase activity
BRW62_RS10695	COG4956	integral membrane protein (PIN domain superfamily)
BRW62_RS10700	COG1215	transferase activity, transferring glycosyl groups
BRW62_RS10705	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRW62_RS10740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRW62_RS10745	COG0443	Heat shock 70 kDa protein
BRW62_RS10760	COG0300	oxidoreductase activity
BRW62_RS10765	COG1266	CAAX protease self-immunity
BRW62_RS10790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BRW62_RS10800	COG0515	serine threonine protein kinase
BRW62_RS10805	COG3266	domain, Protein
BRW62_RS10805	COG0515	serine threonine protein kinase
BRW62_RS10815	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BRW62_RS10820	COG0745	RESPONSE REGULATOR receiver
BRW62_RS10870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BRW62_RS10875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW62_RS10880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BRW62_RS10900	COG0058	SHG alpha-glucan phosphorylase activity
BRW62_RS10905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BRW62_RS10910	COG0564	pseudouridine synthase activity
BRW62_RS10915	COG0644	oxidoreductase
BRW62_RS10935	COG0504	CTP synthase activity
BRW62_RS10960	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRW62_RS10960	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRW62_RS10975	COG1285	pathogenesis
BRW62_RS10980	COG0577	efflux transmembrane transporter activity
BRW62_RS10980	COG1136	(ABC) transporter
BRW62_RS10985	COG0529	Catalyzes the synthesis of activated sulfate
BRW62_RS10990	COG0587	DNA-directed DNA polymerase activity
BRW62_RS11005	COG1573	uracil-dna glycosylase
BRW62_RS11020	COG0237	dephospho-CoA kinase activity
BRW62_RS11025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRW62_RS11030	COG1413	lyase activity
BRW62_RS11035	COG1413	lyase activity
BRW62_RS11040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BRW62_RS11045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BRW62_RS11050	COG0237	dephospho-CoA kinase activity
BRW62_RS11075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRW62_RS11085	COG0646	methionine synthase
BRW62_RS11085	COG1410	methionine synthase
BRW62_RS11090	COG0772	Belongs to the SEDS family
BRW62_RS11105	COG0778	Nitroreductase
BRW62_RS11110	COG3659	wide pore channel activity
BRW62_RS11130	COG0832	Belongs to the urease beta subunit family
BRW62_RS11190	COG2208	phosphoserine phosphatase activity
BRW62_RS11200	COG1381	Involved in DNA repair and RecF pathway recombination
BRW62_RS11210	COG1063	alcohol dehydrogenase
BRW62_RS11235	COG2884	Cell division ATP-binding protein ftsE
BRW62_RS11245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRW62_RS11250	COG0802	atpase or kinase
BRW62_RS11255	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BRW62_RS11270	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRW62_RS11285	COG0739	heme binding
BRW62_RS11290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BRW62_RS11315	COG0840	transmembrane signaling receptor activity
BRW62_RS11320	COG0643	Histidine kinase
BRW62_RS11320	COG2198	Histidine kinase
BRW62_RS11335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BRW62_RS11340	COG0583	DNA-binding transcription factor activity
BRW62_RS11370	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRW62_RS11375	COG0395	ABC-type sugar transport system, permease component
BRW62_RS11410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BRW62_RS11435	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BRW62_RS11460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BRW62_RS11470	COG0840	transmembrane signaling receptor activity
BRW62_RS11490	COG0450	alkyl hydroperoxide reductase
BRW62_RS11495	COG0765	amino acid transport
BRW62_RS11525	COG0438	transferase activity, transferring glycosyl groups
BRW62_RS11530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRW62_RS11550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BRW62_RS11555	COG0436	Aminotransferase
BRW62_RS11570	COG0131	Imidazoleglycerol-phosphate dehydratase
BRW62_RS11605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BRW62_RS11605	COG0758	DNA mediated transformation
BRW62_RS11610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW62_RS11615	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW62_RS11645	COG0629	single-stranded DNA binding
BRW62_RS11675	COG0250	Participates in transcription elongation, termination and antitermination
BRW62_RS11680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BRW62_RS11685	COG0081	regulation of translation
BRW62_RS11690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BRW62_RS11695	COG0222	ribosome binding
BRW62_RS11705	COG0384	phenazine biosynthesis protein PhzF
BRW62_RS11710	COG0105	UTP biosynthetic process
BRW62_RS11715	COG0861	Integral membrane protein TerC family
BRW62_RS11720	COG3977	Valine--pyruvate aminotransferase
BRW62_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
BRW62_RS11745	COG0739	heme binding
BRW62_RS11745	COG0741	lytic transglycosylase activity
BRW62_RS11745	COG1196	nuclear chromosome segregation
BRW62_RS11765	COG0589	response to stress
BRW62_RS11775	COG2010	Cytochrome c
BRW62_RS11785	COG2203	Gaf domain
BRW62_RS11785	COG3706	GGDEF domain
BRW62_RS11785	COG5001	Diguanylate cyclase
BRW62_RS11785	COG4251	negative regulation of phosphorylation
BRW62_RS11790	COG0667	Aldo Keto reductase
BRW62_RS11800	COG2099	Precorrin-6x reductase
BRW62_RS11805	COG0372	Belongs to the citrate synthase family
BRW62_RS11810	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BRW62_RS11815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRW62_RS11835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRW62_RS11840	COG0515	serine threonine protein kinase
BRW62_RS11855	COG4172	Belongs to the ABC transporter superfamily
BRW62_RS11870	COG0463	Glycosyl transferase, family 2
BRW62_RS11870	COG0457	Tetratricopeptide repeat
BRW62_RS11890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BRW62_RS11895	COG0237	dephospho-CoA kinase activity
BRW62_RS11895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BRW62_RS11905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BRW62_RS11925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BRW62_RS11940	COG0640	Transcriptional regulator
BRW62_RS12000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BRW62_RS12040	COG0628	permease
BRW62_RS12045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BRW62_RS12050	COG0681	Belongs to the peptidase S26 family
BRW62_RS12060	COG0330	HflC and HflK could
BRW62_RS12065	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRW62_RS12085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BRW62_RS12095	COG1982	Orn Lys Arg decarboxylase major
BRW62_RS12105	COG2226	methyltransferase
BRW62_RS12145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRW62_RS12170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BRW62_RS12175	COG0083	homoserine kinase activity
BRW62_RS12195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BRW62_RS12215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BRW62_RS12235	COG0129	dihydroxy-acid dehydratase activity
BRW62_RS12255	COG0180	Tryptophanyl-tRNA synthetase
BRW62_RS12280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BRW62_RS12285	COG1012	belongs to the aldehyde dehydrogenase family
BRW62_RS12285	COG1454	alcohol dehydrogenase
BRW62_RS12295	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BRW62_RS12300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRW62_RS12300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRW62_RS12330	COG0469	pyruvate kinase activity
BRW62_RS12340	COG1324	tolerance protein
BRW62_RS12385	COG2226	methyltransferase
BRW62_RS12400	COG0745	RESPONSE REGULATOR receiver
BRW62_RS12410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRW62_RS12425	COG0788	formyltetrahydrofolate deformylase activity
BRW62_RS12430	COG0009	L-threonylcarbamoyladenylate synthase
BRW62_RS12435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BRW62_RS12465	COG1045	serine acetyltransferase
BRW62_RS12470	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BRW62_RS12490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BRW62_RS12495	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BRW62_RS12500	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BRW62_RS12505	COG0765	amino acid transport
BRW62_RS12510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BRW62_RS12515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BRW62_RS12520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BRW62_RS12545	COG5002	protein histidine kinase activity
BRW62_RS12585	COG0651	ATP synthesis coupled electron transport
BRW62_RS12590	COG1006	Multisubunit Na H antiporter MnhC subunit
BRW62_RS12595	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW62_RS12605	COG3001	Fructosamine kinase
BRW62_RS12610	COG0124	histidyl-tRNA synthetase
BRW62_RS12630	COG0640	Transcriptional regulator
BRW62_RS12650	COG0745	RESPONSE REGULATOR receiver
BRW62_RS12655	COG1691	(AIR) carboxylase
BRW62_RS12670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRW62_RS12695	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRW62_RS12700	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRW62_RS12715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BRW62_RS12720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRW62_RS12745	COG0438	transferase activity, transferring glycosyl groups
BRW62_RS12780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRW62_RS12790	COG1090	epimerase
BRW62_RS12805	COG2045	Belongs to the ComB family
BRW62_RS12815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BRW62_RS12820	COG1132	(ABC) transporter
BRW62_RS12845	COG2205	protein histidine kinase activity
BRW62_RS12850	COG0523	cobalamin synthesis protein
BRW62_RS12880	COG0412	Dienelactone hydrolase
BRW62_RS12885	COG0469	pyruvate kinase activity
BRW62_RS12910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BRW62_RS12925	COG2252	PERMEase
BRW62_RS12955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BRW62_RS12970	COG0706	membrane insertase activity
BRW62_RS12975	COG0594	ribonuclease P activity
BRW62_RS12980	COG0230	Belongs to the bacterial ribosomal protein bL34 family