locus-tag	class	description
SynA1528_RS00005	COG0592	DNA-directed DNA polymerase activity
SynA1528_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1528_RS00020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynA1528_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1528_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynA1528_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1528_RS00055	COG0552	protein localization to endoplasmic reticulum
SynA1528_RS00060	COG2208	phosphoserine phosphatase activity
SynA1528_RS00065	COG0165	Argininosuccinate lyase
SynA1528_RS00070	COG0724	RNA recognition motif
SynA1528_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1528_RS00080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1528_RS00085	COG2081	HI0933 family
SynA1528_RS00090	COG1459	type II secretion system
SynA1528_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynA1528_RS00110	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynA1528_RS00115	COG0484	heat shock protein binding
SynA1528_RS00125	COG1162	GTPase activity
SynA1528_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynA1528_RS00135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynA1528_RS00140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynA1528_RS00145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1528_RS00150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynA1528_RS00155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1528_RS00160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynA1528_RS00165	COG0511	ligase activity, forming carbon-carbon bonds
SynA1528_RS00170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynA1528_RS00235	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynA1528_RS00240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynA1528_RS00240	COG0519	Catalyzes the synthesis of GMP from XMP
SynA1528_RS00255	COG0768	penicillin binding
SynA1528_RS00260	COG0438	transferase activity, transferring glycosyl groups
SynA1528_RS00265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1528_RS00275	COG2022	thiamine diphosphate biosynthetic process
SynA1528_RS00290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynA1528_RS00295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynA1528_RS00300	COG2385	sporulation resulting in formation of a cellular spore
SynA1528_RS00305	COG1215	transferase activity, transferring glycosyl groups
SynA1528_RS00315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynA1528_RS00325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynA1528_RS00330	COG0740	serine-type endopeptidase activity
SynA1528_RS00335	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynA1528_RS00340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynA1528_RS00345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynA1528_RS00350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynA1528_RS00360	COG0527	aspartate kinase activity
SynA1528_RS00370	COG2082	Precorrin-8x methylmutase
SynA1528_RS00375	COG0037	tRNA processing
SynA1528_RS00395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynA1528_RS00400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynA1528_RS00410	COG0556	nucleotide-excision repair
SynA1528_RS00425	COG0463	Glycosyl transferase, family 2
SynA1528_RS00490	COG0653	protein targeting
SynA1528_RS00505	COG1045	serine acetyltransferase
SynA1528_RS00510	COG1725	Transcriptional regulator
SynA1528_RS00520	COG0297	glycogen (starch) synthase activity
SynA1528_RS00525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynA1528_RS00530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynA1528_RS00535	COG1372	Participates in initiation and elongation during chromosome replication
SynA1528_RS00535	COG0187	DNA topoisomerase II activity
SynA1528_RS00545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1528_RS00550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1528_RS00555	COG0386	Belongs to the glutathione peroxidase family
SynA1528_RS00560	COG2239	Acts as a magnesium transporter
SynA1528_RS00565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1528_RS00585	COG1194	a g-specific adenine glycosylase
SynA1528_RS00600	COG0802	atpase or kinase
SynA1528_RS00605	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynA1528_RS00610	COG0586	Pfam SNARE associated Golgi protein
SynA1528_RS00615	COG0629	single-stranded DNA binding
SynA1528_RS00640	COG0745	RESPONSE REGULATOR receiver
SynA1528_RS00645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynA1528_RS00665	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynA1528_RS00670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynA1528_RS00705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynA1528_RS00710	COG2255	four-way junction helicase activity
SynA1528_RS00720	COG1473	amidohydrolase
SynA1528_RS00735	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynA1528_RS00770	COG0028	Belongs to the TPP enzyme family
SynA1528_RS00795	COG0535	radical SAM domain protein
SynA1528_RS00800	COG1088	dTDP-glucose 4,6-dehydratase activity
SynA1528_RS00805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SynA1528_RS00805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SynA1528_RS00810	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SynA1528_RS00820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynA1528_RS00840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynA1528_RS00845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynA1528_RS00850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA1528_RS00855	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1528_RS00860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynA1528_RS00865	COG0662	Cupin 2, conserved barrel domain protein
SynA1528_RS00865	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynA1528_RS00890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynA1528_RS00900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1528_RS00905	COG0571	ribonuclease III activity
SynA1528_RS00930	COG0058	SHG alpha-glucan phosphorylase activity
SynA1528_RS00935	COG0475	glutathione-regulated potassium exporter activity
SynA1528_RS00955	COG0277	FAD linked oxidase domain protein
SynA1528_RS00965	COG0247	lactate metabolic process
SynA1528_RS00970	COG0538	isocitrate dehydrogenase activity
SynA1528_RS00975	COG0463	Glycosyl transferase, family 2
SynA1528_RS00995	COG5398	heme oxygenase
SynA1528_RS01005	COG1132	(ABC) transporter
SynA1528_RS01010	COG0438	transferase activity, transferring glycosyl groups
SynA1528_RS01015	COG0438	transferase activity, transferring glycosyl groups
SynA1528_RS01020	COG0438	transferase activity, transferring glycosyl groups
SynA1528_RS01025	COG0438	transferase activity, transferring glycosyl groups
SynA1528_RS01040	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynA1528_RS01060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynA1528_RS01070	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynA1528_RS01075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynA1528_RS01075	COG0517	IMP dehydrogenase activity
SynA1528_RS01080	COG0617	tRNA 3'-terminal CCA addition
SynA1528_RS01080	COG0517	IMP dehydrogenase activity
SynA1528_RS01080	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynA1528_RS01090	COG0709	Synthesizes selenophosphate from selenide and ATP
SynA1528_RS01095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1528_RS01105	COG2274	protein secretion by the type I secretion system
SynA1528_RS01115	COG0438	transferase activity, transferring glycosyl groups
SynA1528_RS01120	COG0124	histidyl-tRNA synthetase
SynA1528_RS01125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1528_RS01130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynA1528_RS01160	COG4447	cellulose binding
SynA1528_RS01165	COG1773	rubredoxin
SynA1528_RS01170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1528_RS01175	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1528_RS01180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1528_RS01185	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynA1528_RS01190	COG3842	ATPase activity
SynA1528_RS01200	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1528_RS01200	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1528_RS01205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SynA1528_RS01210	COG4988	ABC transporter
SynA1528_RS01215	COG0494	nUDIX hydrolase
SynA1528_RS01220	COG0415	Belongs to the DNA photolyase family
SynA1528_RS01250	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynA1528_RS01255	COG0131	Imidazoleglycerol-phosphate dehydratase
SynA1528_RS01260	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynA1528_RS01265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynA1528_RS01285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1528_RS01290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1528_RS01300	COG0354	folic acid binding
SynA1528_RS01305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynA1528_RS01320	COG1253	flavin adenine dinucleotide binding
SynA1528_RS01325	COG0673	inositol 2-dehydrogenase activity
SynA1528_RS01345	COG0343	queuine tRNA-ribosyltransferase activity
SynA1528_RS01355	COG2205	protein histidine kinase activity
SynA1528_RS01370	COG0138	bifunctional purine biosynthesis protein purh
SynA1528_RS01385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynA1528_RS01390	COG0004	ammonium transporteR
SynA1528_RS01395	COG1489	DNA binding
SynA1528_RS01400	COG0728	peptidoglycan biosynthetic process
SynA1528_RS01425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynA1528_RS01430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1528_RS01435	COG1546	Belongs to the CinA family
SynA1528_RS01435	COG1058	Belongs to the CinA family
SynA1528_RS01440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynA1528_RS01445	COG0066	3-isopropylmalate dehydratase activity
SynA1528_RS01480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA1528_RS01485	COG0193	aminoacyl-tRNA hydrolase activity
SynA1528_RS01500	COG4372	Transposase
SynA1528_RS01505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1528_RS01510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynA1528_RS01520	COG0717	Belongs to the dCTP deaminase family
SynA1528_RS01530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA1528_RS01540	COG0741	lytic transglycosylase activity
SynA1528_RS01545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1528_RS01550	COG2971	BadF BadG BcrA BcrD
SynA1528_RS01560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynA1528_RS01580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynA1528_RS01595	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynA1528_RS01650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1528_RS01665	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynA1528_RS01670	COG2094	Belongs to the DNA glycosylase MPG family
SynA1528_RS01675	COG0540	Belongs to the ATCase OTCase family
SynA1528_RS01700	COG3536	Protein conserved in bacteria
SynA1528_RS01705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynA1528_RS01720	COG0529	Catalyzes the synthesis of activated sulfate
SynA1528_RS01720	COG2046	Belongs to the sulfate adenylyltransferase family
SynA1528_RS01725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1528_RS01730	COG0800	Aldolase
SynA1528_RS01740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynA1528_RS01775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1528_RS01795	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynA1528_RS01800	COG0719	Fe-S assembly protein
SynA1528_RS01805	COG0396	ATPase activity
SynA1528_RS01810	COG0719	Fe-S assembly protein
SynA1528_RS01815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynA1528_RS01830	COG0242	peptide deformylase activity
SynA1528_RS01845	COG0606	chelatase, subunit chli
SynA1528_RS01850	COG0537	adenosine 5'-monophosphoramidase activity
SynA1528_RS01855	COG4178	(ABC) transporter
SynA1528_RS01875	COG0515	serine threonine protein kinase
SynA1528_RS01890	COG0439	Biotin carboxylase
SynA1528_RS01900	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1528_RS01905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1528_RS01920	COG1196	nuclear chromosome segregation
SynA1528_RS01940	COG0116	Belongs to the methyltransferase superfamily
SynA1528_RS02100	COG0300	oxidoreductase activity
SynA1528_RS02115	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SynA1528_RS02150	COG2089	acid synthase
SynA1528_RS02170	COG1083	cytidylyl-transferase
SynA1528_RS02185	COG3562	capsule polysaccharide
SynA1528_RS02195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA1528_RS02210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynA1528_RS02220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynA1528_RS02225	COG1333	cytochrome c biogenesis protein
SynA1528_RS02235	COG0772	Belongs to the SEDS family
SynA1528_RS02270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1528_RS02275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1528_RS02285	COG0356	it plays a direct role in the translocation of protons across the membrane
SynA1528_RS02290	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1528_RS02295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1528_RS02300	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1528_RS02305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1528_RS02310	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynA1528_RS02315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynA1528_RS02325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1528_RS02335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1528_RS02340	COG3012	SEC-C Motif Domain Protein
SynA1528_RS02350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1528_RS02350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynA1528_RS02355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynA1528_RS02360	COG1160	GTP binding
SynA1528_RS02365	COG1253	flavin adenine dinucleotide binding
SynA1528_RS02370	COG0006	proline dipeptidase activity
SynA1528_RS02375	COG0387	Pfam Sodium calcium exchanger
SynA1528_RS02390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynA1528_RS02395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynA1528_RS02400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynA1528_RS02405	COG0459	protein refolding
SynA1528_RS02430	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynA1528_RS02435	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynA1528_RS02450	COG0443	Heat shock 70 kDa protein
SynA1528_RS02485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynA1528_RS02505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynA1528_RS02510	COG2264	protein methyltransferase activity
SynA1528_RS02525	COG2010	Cytochrome c
SynA1528_RS02530	COG1234	tRNA 3'-trailer cleavage
SynA1528_RS02535	COG2385	sporulation resulting in formation of a cellular spore
SynA1528_RS02540	COG0363	glucosamine-6-phosphate deaminase activity
SynA1528_RS02555	COG0217	transcriptional regulatory protein
SynA1528_RS02560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynA1528_RS02565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1528_RS02570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynA1528_RS02575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynA1528_RS02585	COG4251	negative regulation of phosphorylation
SynA1528_RS02590	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynA1528_RS02595	COG5002	protein histidine kinase activity
SynA1528_RS02600	COG0151	Belongs to the GarS family
SynA1528_RS02610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynA1528_RS02620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynA1528_RS02625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynA1528_RS02630	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1528_RS02635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1528_RS02640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1528_RS02655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynA1528_RS02680	COG2197	response regulator
SynA1528_RS02690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynA1528_RS02695	COG0284	orotidine-5'-phosphate decarboxylase activity
SynA1528_RS02700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynA1528_RS02735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynA1528_RS02740	COG2211	Major facilitator Superfamily
SynA1528_RS02760	COG0776	regulation of translation
SynA1528_RS02765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1528_RS02785	COG1053	succinate dehydrogenase
SynA1528_RS02820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynA1528_RS02830	COG0195	Participates in both transcription termination and antitermination
SynA1528_RS02835	COG0779	Required for maturation of 30S ribosomal subunits
SynA1528_RS02850	COG0641	radical SAM
SynA1528_RS02865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1528_RS02870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynA1528_RS02875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynA1528_RS02880	COG0268	Binds directly to 16S ribosomal RNA
SynA1528_RS02885	COG0084	hydrolase, TatD family'
SynA1528_RS02890	COG0085	RNA polymerase activity
SynA1528_RS02895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1528_RS02900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1528_RS02910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynA1528_RS02925	COG1134	teichoic acid transport
SynA1528_RS02960	COG0357	Ribosomal RNA small subunit methyltransferase G
SynA1528_RS02965	COG0484	heat shock protein binding
SynA1528_RS02975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynA1528_RS02990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynA1528_RS02990	COG4106	trans-aconitate 2-methyltransferase activity
SynA1528_RS03010	COG0385	Bile acid
SynA1528_RS03015	COG4581	dead DEAH box helicase
SynA1528_RS03020	COG0114	fumarate hydratase activity
SynA1528_RS03040	COG1216	Glycosyl transferase, family 2
SynA1528_RS03040	COG0438	transferase activity, transferring glycosyl groups
SynA1528_RS03060	COG0438	transferase activity, transferring glycosyl groups
SynA1528_RS03060	COG1216	Glycosyl transferase, family 2
SynA1528_RS03095	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynA1528_RS03110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1528_RS03120	COG1160	GTP binding
SynA1528_RS03125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynA1528_RS03135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynA1528_RS03140	COG1799	cell septum assembly
SynA1528_RS03145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynA1528_RS03150	COG0438	transferase activity, transferring glycosyl groups
SynA1528_RS03160	COG1381	Involved in DNA repair and RecF pathway recombination
SynA1528_RS03165	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynA1528_RS03170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynA1528_RS03175	COG0321	lipoyl(octanoyl) transferase activity
SynA1528_RS03180	COG1022	Amp-dependent synthetase and ligase
SynA1528_RS03190	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA1528_RS03195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynA1528_RS03235	COG2217	Heavy metal translocating P-type atpase
SynA1528_RS03235	COG2608	mercury ion transmembrane transporter activity
SynA1528_RS03250	COG2119	membrane
SynA1528_RS03260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1528_RS03290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1528_RS03295	COG0440	acetolactate synthase activity
SynA1528_RS03300	COG2267	carboxylic ester hydrolase activity
SynA1528_RS03325	COG2226	methyltransferase
SynA1528_RS03335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynA1528_RS03340	COG0492	ferredoxin-NADP+ reductase activity
SynA1528_RS03380	COG0429	hydrolase of the alpha beta-hydrolase fold
SynA1528_RS03395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynA1528_RS03400	COG0733	neurotransmitter:sodium symporter activity
SynA1528_RS03410	COG0215	cysteine-tRNA ligase activity
SynA1528_RS03415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1528_RS03415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1528_RS03425	COG0012	GTP binding
SynA1528_RS03430	COG2814	Major facilitator Superfamily
SynA1528_RS03440	COG0601	transmembrane transport
SynA1528_RS03455	COG0460	homoserine dehydrogenase
SynA1528_RS03460	COG2166	iron-sulfur cluster assembly
SynA1528_RS03470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynA1528_RS03475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynA1528_RS03480	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1528_RS03495	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynA1528_RS03500	COG2010	Cytochrome c
SynA1528_RS03510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynA1528_RS03515	COG3118	belongs to the thioredoxin family
SynA1528_RS03520	COG0516	GMP reductase activity
SynA1528_RS03530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1528_RS03535	COG0644	oxidoreductase
SynA1528_RS03540	COG1543	Belongs to the glycosyl hydrolase 57 family
SynA1528_RS03545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynA1528_RS03550	COG0395	ABC-type sugar transport system, permease component
SynA1528_RS03570	COG0011	TIGRFAM Protein of
SynA1528_RS03580	COG0564	pseudouridine synthase activity
SynA1528_RS03595	COG1480	7TM receptor with intracellular HD hydrolase
SynA1528_RS03600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynA1528_RS03620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA1528_RS03630	COG0406	alpha-ribazole phosphatase activity
SynA1528_RS03635	COG1254	Belongs to the acylphosphatase family
SynA1528_RS03640	COG1797	cobyrinic acid a,c-diamide synthase activity
SynA1528_RS03650	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynA1528_RS03670	COG2205	protein histidine kinase activity
SynA1528_RS03685	COG0308	aminopeptidase N
SynA1528_RS03705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1528_RS03745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA1528_RS03785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynA1528_RS03795	COG2197	response regulator
SynA1528_RS03800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA1528_RS03815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynA1528_RS03830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynA1528_RS03835	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1528_RS03840	COG0473	3-isopropylmalate dehydrogenase activity
SynA1528_RS03845	COG3954	Phosphoribulokinase
SynA1528_RS03855	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynA1528_RS03860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynA1528_RS03870	COG0673	inositol 2-dehydrogenase activity
SynA1528_RS03875	COG0191	fructose-bisphosphate aldolase activity
SynA1528_RS03880	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1528_RS03885	COG0047	phosphoribosylformylglycinamidine synthase activity
SynA1528_RS03890	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1528_RS03900	COG0668	transmembrane transport
SynA1528_RS03910	COG0640	Transcriptional regulator
SynA1528_RS03915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1528_RS04000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA1528_RS04015	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1528_RS04025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynA1528_RS04030	COG1429	ligase activity, forming nitrogen-metal bonds
SynA1528_RS04040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynA1528_RS04045	COG0149	triose-phosphate isomerase activity
SynA1528_RS04055	COG1132	(ABC) transporter
SynA1528_RS04065	COG1115	amino acid carrier protein
SynA1528_RS04075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynA1528_RS04085	COG0799	negative regulation of ribosome biogenesis
SynA1528_RS04125	COG0659	secondary active sulfate transmembrane transporter activity
SynA1528_RS04135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynA1528_RS04140	COG4597	amino acid ABC transporter
SynA1528_RS04145	COG0765	amino acid transport
SynA1528_RS04190	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynA1528_RS04225	COG0625	glutathione transferase activity
SynA1528_RS04255	COG1799	cell septum assembly
SynA1528_RS04270	COG0735	belongs to the Fur family
SynA1528_RS04285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynA1528_RS04330	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynA1528_RS04360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynA1528_RS04370	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynA1528_RS04390	COG0745	RESPONSE REGULATOR receiver
SynA1528_RS04400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynA1528_RS04405	COG0271	Belongs to the BolA IbaG family
SynA1528_RS04420	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynA1528_RS04440	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynA1528_RS04450	COG1074	ATP-dependent DNA helicase activity
SynA1528_RS04455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA1528_RS04465	COG0513	Belongs to the DEAD box helicase family
SynA1528_RS04480	COG0724	RNA recognition motif
SynA1528_RS04485	COG1132	(ABC) transporter
SynA1528_RS04490	COG0589	response to stress
SynA1528_RS04490	COG0475	glutathione-regulated potassium exporter activity
SynA1528_RS04505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynA1528_RS04510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1528_RS04535	COG1054	Belongs to the UPF0176 family
SynA1528_RS04540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynA1528_RS04545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynA1528_RS04550	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynA1528_RS04555	COG0019	diaminopimelate decarboxylase activity
SynA1528_RS04565	COG0542	response to heat
SynA1528_RS04570	COG0371	Dehydrogenase
SynA1528_RS04575	COG2267	carboxylic ester hydrolase activity
SynA1528_RS04585	COG0575	Belongs to the CDS family
SynA1528_RS04590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA1528_RS04595	COG1982	Orn Lys Arg decarboxylase major
SynA1528_RS04600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1528_RS04610	COG0745	RESPONSE REGULATOR receiver
SynA1528_RS04615	COG5002	protein histidine kinase activity
SynA1528_RS04620	COG1187	pseudouridine synthase activity
SynA1528_RS04630	COG1640	4-alpha-glucanotransferase
SynA1528_RS04650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynA1528_RS04675	COG1121	(ABC) transporter
SynA1528_RS04700	COG0701	Predicted permease
SynA1528_RS04745	COG0644	oxidoreductase
SynA1528_RS04780	COG2144	transferase activity, transferring acyl groups
SynA1528_RS04810	COG0681	Belongs to the peptidase S26 family
SynA1528_RS04815	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynA1528_RS04820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynA1528_RS04825	COG1376	ErfK ybiS ycfS ynhG family protein
SynA1528_RS04830	COG0297	glycogen (starch) synthase activity
SynA1528_RS04840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynA1528_RS04845	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynA1528_RS04865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynA1528_RS04870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynA1528_RS04875	COG2045	Belongs to the ComB family
SynA1528_RS04885	COG0860	N-Acetylmuramoyl-L-alanine amidase
SynA1528_RS04890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynA1528_RS04895	COG0142	geranyltranstransferase activity
SynA1528_RS04900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynA1528_RS04905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynA1528_RS04915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1528_RS04920	COG2176	DNA-directed DNA polymerase activity
SynA1528_RS04935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1528_RS04955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1528_RS04965	COG1132	(ABC) transporter
SynA1528_RS04975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1528_RS04980	COG0505	Belongs to the CarA family
SynA1528_RS04990	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynA1528_RS04995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1528_RS05005	COG0154	amidase activity
SynA1528_RS05010	COG0587	DNA-directed DNA polymerase activity
SynA1528_RS05020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynA1528_RS05025	COG0632	four-way junction helicase activity
SynA1528_RS05030	COG1006	Multisubunit Na H antiporter MnhC subunit
SynA1528_RS05035	COG1007	ATP synthesis coupled electron transport
SynA1528_RS05060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1528_RS05065	COG1809	phosphosulfolactate synthase activity
SynA1528_RS05070	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SynA1528_RS05090	COG0358	DNA primase activity
SynA1528_RS05095	COG0798	PFAM Bile acid sodium symporter
SynA1528_RS05115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1528_RS05135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynA1528_RS05150	COG0792	nuclease activity
SynA1528_RS05195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynA1528_RS05200	COG1611	Belongs to the LOG family
SynA1528_RS05270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynA1528_RS05275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynA1528_RS05285	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA1528_RS05285	COG0022	dehydrogenase e1 component
SynA1528_RS05290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1528_RS05295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1528_RS05330	COG0628	permease
SynA1528_RS05340	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynA1528_RS05345	COG0515	serine threonine protein kinase
SynA1528_RS05375	COG0174	glutamine synthetase
SynA1528_RS05385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynA1528_RS05405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynA1528_RS05425	COG0612	Peptidase, M16
SynA1528_RS05455	COG1216	Glycosyl transferase, family 2
SynA1528_RS05460	COG0052	Belongs to the universal ribosomal protein uS2 family
SynA1528_RS05465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynA1528_RS05475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynA1528_RS05480	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynA1528_RS05485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1528_RS05490	COG0751	glycine-tRNA ligase activity
SynA1528_RS05500	COG0644	oxidoreductase
SynA1528_RS05510	COG0826	peptidase U32
SynA1528_RS05515	COG1217	gtp-binding protein TYPA
SynA1528_RS05540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynA1528_RS05565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynA1528_RS05570	COG1494	fructose-1,6-bisphosphatase
SynA1528_RS05575	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynA1528_RS05580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1528_RS05585	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynA1528_RS05590	COG0363	glucosamine-6-phosphate deaminase activity
SynA1528_RS05605	COG0129	dihydroxy-acid dehydratase activity
SynA1528_RS05615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynA1528_RS05695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynA1528_RS05700	COG4106	trans-aconitate 2-methyltransferase activity
SynA1528_RS05705	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynA1528_RS05725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynA1528_RS05730	COG1129	ABC transporter
SynA1528_RS05740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SynA1528_RS05750	COG1836	PFAM Integral membrane protein DUF92
SynA1528_RS05780	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynA1528_RS05785	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynA1528_RS05790	COG0436	Aminotransferase
SynA1528_RS05800	COG1573	uracil-dna glycosylase
SynA1528_RS05805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynA1528_RS05810	COG0793	Belongs to the peptidase S41A family
SynA1528_RS05820	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynA1528_RS05845	COG0861	Integral membrane protein TerC family
SynA1528_RS05865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynA1528_RS05875	COG0312	modulator of DNA gyrase
SynA1528_RS05880	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynA1528_RS05895	COG0163	prenyltransferase activity
SynA1528_RS05900	COG0557	exoribonuclease II activity
SynA1528_RS05905	COG2119	membrane
SynA1528_RS05910	COG2119	membrane
SynA1528_RS05925	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynA1528_RS05925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynA1528_RS05945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynA1528_RS05950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1528_RS05955	COG1615	UPF0182 protein
SynA1528_RS05960	COG0450	alkyl hydroperoxide reductase
SynA1528_RS05970	COG0739	heme binding
SynA1528_RS05975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynA1528_RS06010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA1528_RS06020	COG0557	exoribonuclease II activity
SynA1528_RS06025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynA1528_RS06030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynA1528_RS06035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA1528_RS06035	COG0072	phenylalanine-tRNA ligase activity
SynA1528_RS06040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynA1528_RS06100	COG0646	methionine synthase
SynA1528_RS06100	COG1410	methionine synthase
SynA1528_RS06105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynA1528_RS06125	COG1981	membrane
SynA1528_RS06130	COG3046	protein related to deoxyribodipyrimidine photolyase
SynA1528_RS06140	COG0322	excinuclease ABC activity
SynA1528_RS06150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynA1528_RS06180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynA1528_RS06190	COG0495	leucyl-tRNA aminoacylation
SynA1528_RS06195	COG0166	Belongs to the GPI family
SynA1528_RS06225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynA1528_RS06230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynA1528_RS06235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1528_RS06235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1528_RS06240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1528_RS06245	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynA1528_RS06250	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynA1528_RS06260	COG0484	heat shock protein binding
SynA1528_RS06265	COG0443	Heat shock 70 kDa protein
SynA1528_RS06270	COG0573	inorganic phosphate transmembrane transporter activity
SynA1528_RS06275	COG0581	inorganic phosphate transmembrane transporter activity
SynA1528_RS06280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynA1528_RS06295	COG0483	inositol monophosphate 1-phosphatase activity
SynA1528_RS06300	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynA1528_RS06310	COG0326	Molecular chaperone. Has ATPase activity
SynA1528_RS06315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynA1528_RS06320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1528_RS06325	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynA1528_RS06330	COG1653	transport
SynA1528_RS06345	COG3842	ATPase activity
SynA1528_RS06350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA1528_RS06375	COG0644	oxidoreductase
SynA1528_RS06380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynA1528_RS06385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynA1528_RS06410	COG0469	pyruvate kinase activity
SynA1528_RS06415	COG1136	(ABC) transporter
SynA1528_RS06415	COG0577	efflux transmembrane transporter activity
SynA1528_RS06420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1528_RS06435	COG0740	serine-type endopeptidase activity
SynA1528_RS06455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1528_RS06480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynA1528_RS06485	COG1175	transmembrane transport
SynA1528_RS06490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynA1528_RS06545	COG1793	dna ligase
SynA1528_RS06555	COG1201	RNA secondary structure unwinding
SynA1528_RS06570	COG2059	Chromate
SynA1528_RS06610	COG2226	methyltransferase
SynA1528_RS06645	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynA1528_RS06655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1528_RS06685	COG1121	(ABC) transporter
SynA1528_RS06695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynA1528_RS06700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1528_RS06805	COG0724	RNA recognition motif
SynA1528_RS06835	COG0463	Glycosyl transferase, family 2
SynA1528_RS06950	COG0405	Gamma-glutamyltransferase
SynA1528_RS07045	COG2124	cytochrome p450
SynA1528_RS07075	COG0010	Belongs to the arginase family
SynA1528_RS07080	COG0375	protein maturation
SynA1528_RS07095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA1528_RS07100	COG1116	anion transmembrane transporter activity
SynA1528_RS07120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SynA1528_RS07215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynA1528_RS07255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1528_RS07385	COG0180	Tryptophanyl-tRNA synthetase
SynA1528_RS07400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynA1528_RS07410	COG0837	glucose binding
SynA1528_RS07415	COG0083	homoserine kinase activity
SynA1528_RS07420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1528_RS07425	COG0339	signal peptide processing
SynA1528_RS07440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynA1528_RS07480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynA1528_RS07485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynA1528_RS07495	COG3794	PFAM blue (type 1) copper domain protein
SynA1528_RS07525	COG0542	response to heat
SynA1528_RS07530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SynA1528_RS07540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynA1528_RS07540	COG0140	phosphoribosyl-ATP diphosphatase activity
SynA1528_RS07560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1528_RS07595	COG2010	Cytochrome c
SynA1528_RS07610	COG0159	tryptophan synthase activity
SynA1528_RS07635	COG0418	dihydroorotase activity
SynA1528_RS07640	COG0659	secondary active sulfate transmembrane transporter activity
SynA1528_RS07665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynA1528_RS07670	COG1845	cytochrome c oxidase, subunit III
SynA1528_RS07685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1528_RS07705	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynA1528_RS07710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1528_RS07725	COG0456	acetyltransferase
SynA1528_RS07730	COG1132	(ABC) transporter
SynA1528_RS07735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynA1528_RS07740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynA1528_RS07745	COG3842	ATPase activity
SynA1528_RS07750	COG0251	oxidation-reduction process
SynA1528_RS07785	COG0330	HflC and HflK could
SynA1528_RS07805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1528_RS07825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynA1528_RS07830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1528_RS07835	COG2135	peptidase activity
SynA1528_RS07850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1528_RS07850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1528_RS07895	COG0745	RESPONSE REGULATOR receiver
SynA1528_RS07900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1528_RS07905	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynA1528_RS07910	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynA1528_RS08010	COG0196	riboflavin kinase activity
SynA1528_RS08015	COG0352	thiamine-phosphate diphosphorylase activity
SynA1528_RS08035	COG1691	(AIR) carboxylase
SynA1528_RS08045	COG0336	Belongs to the RNA methyltransferase TrmD family
SynA1528_RS08060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynA1528_RS08065	COG3527	Alpha-acetolactate decarboxylase
SynA1528_RS08075	COG0670	Belongs to the BI1 family
SynA1528_RS08080	COG1702	phosphate starvation-inducible protein PhoH
SynA1528_RS08085	COG0228	four-way junction DNA binding
SynA1528_RS08090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynA1528_RS08100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynA1528_RS08105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1528_RS08110	COG0482	sulfurtransferase activity
SynA1528_RS08115	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynA1528_RS08185	COG0134	indole-3-glycerol-phosphate synthase activity
SynA1528_RS08190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1528_RS08195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1528_RS08210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynA1528_RS08215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA1528_RS08220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA1528_RS08225	COG0285	dihydrofolate synthase activity
SynA1528_RS08255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1528_RS08260	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynA1528_RS08275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynA1528_RS08285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynA1528_RS08290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynA1528_RS08295	COG4956	integral membrane protein (PIN domain superfamily)
SynA1528_RS08300	COG0740	serine-type endopeptidase activity
SynA1528_RS08305	COG0740	serine-type endopeptidase activity
SynA1528_RS08310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynA1528_RS08315	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynA1528_RS08320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynA1528_RS08345	COG0752	glycyl-tRNA synthetase alpha subunit
SynA1528_RS08355	COG2226	methyltransferase
SynA1528_RS08360	COG0107	imidazoleglycerol-phosphate synthase activity
SynA1528_RS08370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1528_RS08375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynA1528_RS08380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynA1528_RS08380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1528_RS08385	COG3695	enzyme binding
SynA1528_RS08390	COG0545	Peptidyl-prolyl cis-trans isomerase
SynA1528_RS08395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1528_RS08415	COG5002	protein histidine kinase activity
SynA1528_RS08460	COG0481	GTPase activity
SynA1528_RS08470	COG0579	oxidoreductase
SynA1528_RS08475	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynA1528_RS08500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1528_RS08520	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SynA1528_RS08540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynA1528_RS08550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynA1528_RS08555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynA1528_RS08585	COG3239	Fatty acid desaturase
SynA1528_RS08625	COG0424	maF-like protein
SynA1528_RS08635	COG1492	cobalamin metabolic process
SynA1528_RS08665	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1528_RS08670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1528_RS08675	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1528_RS08700	COG4451	ribulose bisphosphate carboxylase, small
SynA1528_RS08705	COG1850	ribulose-bisphosphate carboxylase activity
SynA1528_RS08710	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1528_RS08715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1528_RS08720	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1528_RS08730	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1528_RS08735	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1528_RS08740	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynA1528_RS08765	COG0730	response to heat
SynA1528_RS08770	COG0095	Lipoate-protein ligase
SynA1528_RS08775	COG1994	Peptidase M50
SynA1528_RS08775	COG0517	IMP dehydrogenase activity
SynA1528_RS08780	COG0135	phosphoribosylanthranilate isomerase activity
SynA1528_RS08785	COG0302	gtp cyclohydrolase
SynA1528_RS08790	COG0300	oxidoreductase activity
SynA1528_RS08795	COG0825	malonyl-CoA metabolic process
SynA1528_RS08800	COG5322	oxidoreductase activity
SynA1528_RS08805	COG3396	Phenylacetate-CoA oxygenase
SynA1528_RS08815	COG0539	negative regulation of cytoplasmic translation
SynA1528_RS08830	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynA1528_RS08850	COG0028	Belongs to the TPP enzyme family
SynA1528_RS08860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1528_RS08870	COG2226	methyltransferase
SynA1528_RS08885	COG0528	UMP kinase activity
SynA1528_RS08890	COG0233	cytoplasmic translational termination
SynA1528_RS08895	COG0644	oxidoreductase
SynA1528_RS08900	COG0415	Belongs to the DNA photolyase family
SynA1528_RS08910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynA1528_RS08915	COG0768	penicillin binding
SynA1528_RS08930	COG0588	phosphoglycerate mutase activity
SynA1528_RS08940	COG0681	Belongs to the peptidase S26 family
SynA1528_RS08960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1528_RS08970	COG0442	prolyl-tRNA aminoacylation
SynA1528_RS08980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynA1528_RS08985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynA1528_RS09000	COG0629	single-stranded DNA binding
SynA1528_RS09015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynA1528_RS09025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynA1528_RS09030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1528_RS09040	COG0181	hydroxymethylbilane synthase activity
SynA1528_RS09055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1528_RS09145	COG0432	Pfam Uncharacterised protein family UPF0047
SynA1528_RS09150	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynA1528_RS09155	COG0523	cobalamin synthesis protein
SynA1528_RS09165	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA1528_RS09190	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynA1528_RS09195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1528_RS09215	COG0708	Exodeoxyribonuclease III
SynA1528_RS09220	COG0277	FAD linked oxidase domain protein
SynA1528_RS09225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynA1528_RS09235	COG0295	cytidine deaminase activity
SynA1528_RS09245	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynA1528_RS09270	COG1666	GTP binding
SynA1528_RS09285	COG0857	belongs to the CobB CobQ family
SynA1528_RS09295	COG3000	fatty acid hydroxylase
SynA1528_RS09295	COG0300	oxidoreductase activity
SynA1528_RS09300	COG0024	Methionine aminopeptidase
SynA1528_RS09310	COG0335	large ribosomal subunit rRNA binding
SynA1528_RS09330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1528_RS09360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1528_RS09365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynA1528_RS09380	COG0194	GDP metabolic process
SynA1528_RS09385	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynA1528_RS09390	COG0805	protein transport
SynA1528_RS09400	COG0723	plastoquinol--plastocyanin reductase activity
SynA1528_RS09405	COG0739	heme binding
SynA1528_RS09410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynA1528_RS09415	COG2875	Belongs to the precorrin methyltransferase family
SynA1528_RS09430	COG0248	Ppx GppA phosphatase
SynA1528_RS09435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1528_RS09440	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1528_RS09445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynA1528_RS09460	COG1028	Short-chain dehydrogenase reductase Sdr
SynA1528_RS09470	COG0459	protein refolding
SynA1528_RS09475	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynA1528_RS09495	COG0109	protoheme IX farnesyltransferase activity
SynA1528_RS09500	COG1612	heme a metabolic process
SynA1528_RS09505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynA1528_RS09515	COG1845	cytochrome c oxidase, subunit III
SynA1528_RS09545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynA1528_RS09560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynA1528_RS09565	COG1007	ATP synthesis coupled electron transport
SynA1528_RS09570	COG0577	efflux transmembrane transporter activity
SynA1528_RS09570	COG1136	(ABC) transporter
SynA1528_RS09595	COG0739	heme binding
SynA1528_RS09600	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynA1528_RS09600	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynA1528_RS09605	COG0436	Aminotransferase
SynA1528_RS09610	COG3118	belongs to the thioredoxin family
SynA1528_RS09615	COG1842	Phage shock protein A
SynA1528_RS09625	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynA1528_RS09635	COG0697	spore germination
SynA1528_RS09640	COG0616	signal peptide processing
SynA1528_RS09655	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynA1528_RS09660	COG0594	ribonuclease P activity
SynA1528_RS09670	COG0706	membrane insertase activity
SynA1528_RS09690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynA1528_RS09695	COG0750	zinc metalloprotease
SynA1528_RS09700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynA1528_RS09705	COG1185	polyribonucleotide nucleotidyltransferase activity
SynA1528_RS09715	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynA1528_RS09760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SynA1528_RS09845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynA1528_RS09850	COG2226	methyltransferase
SynA1528_RS09860	COG4176	ABC-type proline glycine betaine transport system permease component
SynA1528_RS09865	COG2113	Glycine betaine
SynA1528_RS09900	COG2988	succinylglutamate desuccinylase activity
SynA1528_RS09905	COG0435	Glutathione S-transferase
SynA1528_RS09915	COG0488	(ABC) transporter
SynA1528_RS09930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynA1528_RS09935	COG3842	ATPase activity
SynA1528_RS09945	COG1193	negative regulation of DNA recombination
SynA1528_RS09955	COG0113	porphobilinogen synthase activity
SynA1528_RS09960	COG0484	heat shock protein binding
SynA1528_RS09965	COG4243	Vitamin k epoxide reductase
SynA1528_RS09970	COG0659	secondary active sulfate transmembrane transporter activity
SynA1528_RS10025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynA1528_RS10045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynA1528_RS10050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynA1528_RS10060	COG1012	belongs to the aldehyde dehydrogenase family
SynA1528_RS10065	COG0741	lytic transglycosylase activity
SynA1528_RS10065	COG1388	LysM domain
SynA1528_RS10085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynA1528_RS10090	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynA1528_RS10095	COG0235	Class ii aldolase
SynA1528_RS10100	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynA1528_RS10135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1528_RS10140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1528_RS10145	COG0793	Belongs to the peptidase S41A family
SynA1528_RS10150	COG1078	dGTPase activity
SynA1528_RS10155	COG0850	regulation of cytokinetic process
SynA1528_RS10160	COG2894	cell division
SynA1528_RS10165	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynA1528_RS10185	COG0009	L-threonylcarbamoyladenylate synthase
SynA1528_RS10190	COG2890	protein-(glutamine-N5) methyltransferase activity
SynA1528_RS10195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1528_RS10195	COG0758	DNA mediated transformation
SynA1528_RS10230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynA1528_RS10235	COG0539	negative regulation of cytoplasmic translation
SynA1528_RS10240	COG0546	phosphoglycolate phosphatase activity
SynA1528_RS10245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynA1528_RS10265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA1528_RS10300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1528_RS10465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynA1528_RS10470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynA1528_RS10470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynA1528_RS10475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA1528_RS10480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynA1528_RS10520	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynA1528_RS10540	COG0408	coproporphyrinogen oxidase activity
SynA1528_RS10545	COG0489	protein tyrosine kinase activity
SynA1528_RS10550	COG0772	Belongs to the SEDS family
SynA1528_RS10565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynA1528_RS10575	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynA1528_RS10590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynA1528_RS10595	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynA1528_RS10600	COG1606	tRNA processing
SynA1528_RS10605	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynA1528_RS10620	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynA1528_RS10625	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynA1528_RS10655	COG3001	Fructosamine kinase
SynA1528_RS10660	COG1233	COG1233 Phytoene dehydrogenase and related
SynA1528_RS10685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynA1528_RS10700	COG3854	ATPases associated with a variety of cellular activities
SynA1528_RS10715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynA1528_RS10720	COG0088	Forms part of the polypeptide exit tunnel
SynA1528_RS10725	COG0089	rRNA binding
SynA1528_RS10730	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynA1528_RS10735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynA1528_RS10740	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynA1528_RS10745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynA1528_RS10750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynA1528_RS10755	COG0255	Belongs to the universal ribosomal protein uL29 family
SynA1528_RS10760	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynA1528_RS10765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynA1528_RS10770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynA1528_RS10775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynA1528_RS10780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynA1528_RS10785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynA1528_RS10790	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynA1528_RS10795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynA1528_RS10800	COG0200	Binds to the 23S rRNA
SynA1528_RS10805	COG0201	protein transport
SynA1528_RS10810	COG0563	adenylate kinase activity
SynA1528_RS10815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynA1528_RS10820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynA1528_RS10825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynA1528_RS10830	COG0202	RNA polymerase activity
SynA1528_RS10835	COG0203	ribosomal protein L17
SynA1528_RS10840	COG0101	tRNA pseudouridine synthase activity
SynA1528_RS10845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynA1528_RS10850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynA1528_RS10855	COG0254	rRNA binding
SynA1528_RS10860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynA1528_RS10870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynA1528_RS10925	COG1205	dead DEAH box helicase
SynA1528_RS10925	COG1111	helicase
SynA1528_RS10930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynA1528_RS10980	COG0463	Glycosyl transferase, family 2
SynA1528_RS11020	COG2885	chlorophyll binding
SynA1528_RS11025	COG2885	chlorophyll binding
SynA1528_RS11045	COG3659	wide pore channel activity
SynA1528_RS11075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1528_RS11085	COG0069	glutamate synthase activity
SynA1528_RS11085	COG0070	glutamate synthase
SynA1528_RS11085	COG0067	glutamate synthase
SynA1528_RS11100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynA1528_RS11105	COG0049	tRNA binding
SynA1528_RS11110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynA1528_RS11115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynA1528_RS11120	COG0051	transcription antitermination factor activity, RNA binding
SynA1528_RS11125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynA1528_RS11130	COG2226	methyltransferase
SynA1528_RS11135	COG0077	Prephenate dehydratase
SynA1528_RS11135	COG1605	Chorismate mutase
SynA1528_RS11145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynA1528_RS11150	COG1530	ribonuclease E activity
SynA1528_RS11160	COG0436	Aminotransferase
SynA1528_RS11165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1528_RS11190	COG0033	Phosphoglucomutase
SynA1528_RS11200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynA1528_RS11210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynA1528_RS11230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1528_RS11235	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynA1528_RS11240	COG0175	sulfate reduction
SynA1528_RS11245	COG1252	NADH dehydrogenase
SynA1528_RS11250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynA1528_RS11255	COG0471	metal ion transport
SynA1528_RS11255	COG3273	potassium ion transport
SynA1528_RS11260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynA1528_RS11265	COG0569	domain protein
SynA1528_RS11270	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynA1528_RS11295	COG0488	(ABC) transporter
SynA1528_RS11305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1528_RS11320	COG1643	Atp-dependent helicase
SynA1528_RS11325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1528_RS11335	COG1570	exodeoxyribonuclease VII activity
SynA1528_RS11340	COG1722	exodeoxyribonuclease VII activity
SynA1528_RS11400	COG1968	undecaprenyl-diphosphatase activity
SynA1528_RS11410	COG1555	photosystem II stabilization
SynA1528_RS11415	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynA1528_RS11420	COG4243	Vitamin k epoxide reductase
SynA1528_RS11425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1528_RS11440	COG1032	radical SAM domain protein
SynA1528_RS11470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynA1528_RS11500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynA1528_RS11505	COG1472	Belongs to the glycosyl hydrolase 3 family
SynA1528_RS11510	COG0457	Tetratricopeptide repeat
SynA1528_RS11510	COG0463	Glycosyl transferase, family 2
SynA1528_RS11515	COG1587	Uroporphyrinogen-III synthase
SynA1528_RS11530	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1528_RS11535	COG0316	Belongs to the HesB IscA family
SynA1528_RS11555	COG1090	epimerase
SynA1528_RS11575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1528_RS11580	COG3659	wide pore channel activity
SynA1528_RS11585	COG3659	wide pore channel activity
SynA1528_RS11590	COG3659	wide pore channel activity
SynA1528_RS11595	COG3659	wide pore channel activity
SynA1528_RS11630	COG1122	ATPase activity
SynA1528_RS11640	COG0745	RESPONSE REGULATOR receiver
SynA1528_RS11650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynA1528_RS11655	COG2217	Heavy metal translocating P-type atpase
SynA1528_RS11660	COG3063	Type IV pilus biogenesis stability protein PilW
SynA1528_RS11665	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynA1528_RS11675	COG0416	fatty acid biosynthetic process
SynA1528_RS11680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynA1528_RS11685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynA1528_RS11700	COG1214	PFAM Peptidase M22, glycoprotease
SynA1528_RS11710	COG0617	tRNA 3'-terminal CCA addition
SynA1528_RS11715	COG0724	RNA recognition motif
SynA1528_RS11720	COG1562	ergosterol biosynthetic process
SynA1528_RS11725	COG0493	'glutamate synthase
SynA1528_RS11725	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1528_RS11740	COG0583	DNA-binding transcription factor activity
SynA1528_RS11750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1528_RS11755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1528_RS11770	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynA1528_RS11780	COG2197	response regulator
SynA1528_RS11795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1528_RS11800	COG0713	ATP synthesis coupled electron transport
SynA1528_RS11810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1528_RS11815	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynA1528_RS11820	COG0372	Belongs to the citrate synthase family
SynA1528_RS11825	COG2062	phosphohistidine phosphatase, SixA
SynA1528_RS11840	COG1420	regulation of RNA biosynthetic process
SynA1528_RS11845	COG0133	tryptophan synthase activity
SynA1528_RS11850	COG0023	Translation Initiation Factor
SynA1528_RS11855	COG0529	Catalyzes the synthesis of activated sulfate
SynA1528_RS11860	COG0628	permease
SynA1528_RS11865	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynA1528_RS11875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1528_RS11880	COG0564	pseudouridine synthase activity
SynA1528_RS11885	COG0745	RESPONSE REGULATOR receiver
SynA1528_RS11895	COG1104	cysteine desulfurase activity
SynA1528_RS11905	COG0275	rRNA processing
SynA1528_RS11910	COG0649	NAD binding
SynA1528_RS11920	COG0824	Thioesterase
SynA1528_RS11935	COG0318	PFAM AMP-dependent synthetase and ligase
SynA1528_RS11945	COG1575	Belongs to the MenA family. Type 1 subfamily
SynA1528_RS11965	COG0667	Aldo Keto reductase
SynA1528_RS11980	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynA1528_RS11985	COG0189	ligase activity
SynA1528_RS11990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA1528_RS12005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynA1528_RS12010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynA1528_RS12015	COG0512	Glutamine amidotransferase of anthranilate synthase
SynA1528_RS12025	COG0252	asparaginase activity
SynA1528_RS12030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA1528_RS12035	COG0018	arginyl-trna synthetase
SynA1528_RS12040	COG0157	Belongs to the NadC ModD family
SynA1528_RS12050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynA1528_RS12060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynA1528_RS12065	COG4172	Belongs to the ABC transporter superfamily
SynA1528_RS12080	COG2197	response regulator
SynA1528_RS12090	COG0564	pseudouridine synthase activity
SynA1528_RS12095	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynA1528_RS12100	COG0126	phosphoglycerate kinase activity
SynA1528_RS12115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynA1528_RS12120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA1528_RS12125	COG0167	dihydroorotate dehydrogenase activity
SynA1528_RS12130	COG0328	RNA-DNA hybrid ribonuclease activity
SynA1528_RS12140	COG0222	ribosome binding
SynA1528_RS12145	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynA1528_RS12155	COG0081	regulation of translation
SynA1528_RS12160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynA1528_RS12165	COG0250	Participates in transcription elongation, termination and antitermination
SynA1528_RS12170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynA1528_RS12175	COG0542	response to heat
SynA1528_RS12180	COG0346	lactoylglutathione lyase activity
SynA1528_RS12185	COG0148	phosphopyruvate hydratase activity
SynA1528_RS12190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1528_RS12205	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynA1528_RS12210	COG0237	dephospho-CoA kinase activity
SynA1528_RS12220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1528_RS12225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynA1528_RS12225	COG2022	thiamine diphosphate biosynthetic process
SynA1528_RS12245	COG0105	UTP biosynthetic process
SynA1528_RS12250	COG1166	arginine decarboxylase activity
SynA1528_RS12275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynA1528_RS12285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynA1528_RS12300	COG0071	Belongs to the small heat shock protein (HSP20) family
SynA1528_RS12310	COG0426	domain, Protein
SynA1528_RS12310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1528_RS12315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1528_RS12315	COG0426	domain, Protein
SynA1528_RS12320	COG1773	rubredoxin
SynA1528_RS12330	COG1733	regulation of RNA biosynthetic process
SynA1528_RS12340	COG1741	Belongs to the pirin family
SynA1528_RS12355	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA1528_RS12355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA1528_RS12360	COG0509	glycine decarboxylation via glycine cleavage system
SynA1528_RS12365	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynA1528_RS12375	COG0359	binds to the 23S rRNA
SynA1528_RS12380	COG1372	Participates in initiation and elongation during chromosome replication
SynA1528_RS12380	COG1372	Participates in initiation and elongation during chromosome replication
SynA1528_RS12380	COG0305	Participates in initiation and elongation during chromosome replication
SynA1528_RS12380	COG0305	Participates in initiation and elongation during chromosome replication
SynA1528_RS12385	COG0445	tRNA wobble uridine modification
SynA1528_RS12420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1528_RS12445	COG0398	Pfam SNARE associated Golgi protein
SynA1528_RS12465	COG0525	valine-tRNA ligase activity
SynA1528_RS12505	COG4221	oxidoreductase activity
SynA1528_RS12560	COG3956	TIGRFAM MazG family protein
SynA1528_RS12570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynA1528_RS12575	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynA1528_RS12580	COG0010	Belongs to the arginase family
SynA1528_RS12595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynA1528_RS12600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynA1528_RS12605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1528_RS12610	COG0783	Belongs to the Dps family
SynA1528_RS12615	COG0504	CTP synthase activity
SynA1528_RS12620	COG0602	queuosine metabolic process
SynA1528_RS12635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SynA1528_RS12640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynA1528_RS12660	COG0366	Alpha amylase catalytic
SynA1528_RS12665	COG0463	Glycosyl transferase, family 2
SynA1528_RS12725	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynA1528_RS12730	COG0830	nickel cation binding
SynA1528_RS12735	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynA1528_RS12740	COG0829	nickel cation binding
SynA1528_RS12745	COG0831	urea catabolic process
SynA1528_RS12750	COG0832	Belongs to the urease beta subunit family
SynA1528_RS12755	COG0804	urea catabolic process
SynA1528_RS12775	COG0367	asparagine synthase
SynA1528_RS12780	COG0540	Belongs to the ATCase OTCase family
SynA1528_RS12795	COG2308	Evidence 4 Homologs of previously reported genes of
SynA1528_RS12815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynA1528_RS12820	COG0746	molybdenum cofactor guanylyltransferase activity
SynA1528_RS12830	COG0243	molybdopterin cofactor binding
SynA1528_RS12850	COG0315	cyclic pyranopterin monophosphate synthase activity
SynA1528_RS12855	COG0303	'Molybdopterin
SynA1528_RS12870	COG0314	molybdopterin synthase activity
SynA1528_RS12880	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynA1528_RS12885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynA1528_RS12895	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1528_RS12905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1528_RS12910	COG1121	(ABC) transporter
SynA1528_RS12915	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA1528_RS12920	COG0523	cobalamin synthesis protein
SynA1528_RS12935	COG1116	anion transmembrane transporter activity
SynA1528_RS12940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA1528_RS12945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SynA1528_RS12945	COG1116	anion transmembrane transporter activity
SynA1528_RS12950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA1528_RS12960	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynA1528_RS12970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1528_RS12985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynA1528_RS12990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1528_RS12995	COG0170	dolichyl monophosphate biosynthetic process
SynA1528_RS13005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynA1528_RS13010	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynA1528_RS13020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1528_RS13030	COG0788	formyltetrahydrofolate deformylase activity
SynA1528_RS13050	COG0443	Heat shock 70 kDa protein
SynA1528_RS13055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynA1528_RS13065	COG0360	Binds together with S18 to 16S ribosomal RNA
SynA1528_RS13075	COG0137	argininosuccinate synthase activity
SynA1528_RS13090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1528_RS13105	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynA1528_RS13110	COG0438	transferase activity, transferring glycosyl groups
SynA1528_RS13120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynA1528_RS13125	COG0497	DNA recombination
SynA1528_RS13130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1528_RS13140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine