locus-tag	class	description
SynA1544_RS00005	COG0592	DNA-directed DNA polymerase activity
SynA1544_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1544_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1544_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynA1544_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1544_RS00055	COG0552	protein localization to endoplasmic reticulum
SynA1544_RS00060	COG2208	phosphoserine phosphatase activity
SynA1544_RS00065	COG0165	Argininosuccinate lyase
SynA1544_RS00070	COG0724	RNA recognition motif
SynA1544_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1544_RS00085	COG2081	HI0933 family
SynA1544_RS00090	COG1459	type II secretion system
SynA1544_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynA1544_RS00105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynA1544_RS00110	COG0484	heat shock protein binding
SynA1544_RS00120	COG1162	GTPase activity
SynA1544_RS00125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynA1544_RS00130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynA1544_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynA1544_RS00145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1544_RS00150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynA1544_RS00155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1544_RS00160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynA1544_RS00165	COG0511	ligase activity, forming carbon-carbon bonds
SynA1544_RS00170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynA1544_RS00235	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynA1544_RS00240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynA1544_RS00240	COG0519	Catalyzes the synthesis of GMP from XMP
SynA1544_RS00260	COG0768	penicillin binding
SynA1544_RS00265	COG0438	transferase activity, transferring glycosyl groups
SynA1544_RS00270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1544_RS00280	COG2022	thiamine diphosphate biosynthetic process
SynA1544_RS00295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynA1544_RS00300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynA1544_RS00305	COG2385	sporulation resulting in formation of a cellular spore
SynA1544_RS00310	COG1215	transferase activity, transferring glycosyl groups
SynA1544_RS00315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynA1544_RS00325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynA1544_RS00330	COG0740	serine-type endopeptidase activity
SynA1544_RS00335	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynA1544_RS00340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynA1544_RS00345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynA1544_RS00350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynA1544_RS00370	COG2082	Precorrin-8x methylmutase
SynA1544_RS00375	COG0037	tRNA processing
SynA1544_RS00390	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynA1544_RS00410	COG0556	nucleotide-excision repair
SynA1544_RS00420	COG0653	protein targeting
SynA1544_RS00430	COG1045	serine acetyltransferase
SynA1544_RS00435	COG1725	Transcriptional regulator
SynA1544_RS00440	COG0412	Dienelactone hydrolase
SynA1544_RS00445	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynA1544_RS00450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynA1544_RS00455	COG1372	Participates in initiation and elongation during chromosome replication
SynA1544_RS00455	COG0187	DNA topoisomerase II activity
SynA1544_RS00465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1544_RS00470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1544_RS00475	COG0386	Belongs to the glutathione peroxidase family
SynA1544_RS00480	COG2239	Acts as a magnesium transporter
SynA1544_RS00485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1544_RS00490	COG0596	Alpha beta hydrolase
SynA1544_RS00495	COG1194	a g-specific adenine glycosylase
SynA1544_RS00505	COG0802	atpase or kinase
SynA1544_RS00510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynA1544_RS00515	COG0586	Pfam SNARE associated Golgi protein
SynA1544_RS00520	COG0629	single-stranded DNA binding
SynA1544_RS00530	COG1792	Involved in formation and maintenance of cell shape
SynA1544_RS00550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynA1544_RS00570	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynA1544_RS00575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynA1544_RS00580	COG0515	serine threonine protein kinase
SynA1544_RS00585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynA1544_RS00590	COG2255	four-way junction helicase activity
SynA1544_RS00600	COG1473	amidohydrolase
SynA1544_RS00615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynA1544_RS00620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynA1544_RS00625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynA1544_RS00630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA1544_RS00635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1544_RS00640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynA1544_RS00645	COG0662	Cupin 2, conserved barrel domain protein
SynA1544_RS00645	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynA1544_RS00650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynA1544_RS00660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1544_RS00665	COG0571	ribonuclease III activity
SynA1544_RS00695	COG0058	SHG alpha-glucan phosphorylase activity
SynA1544_RS00700	COG0475	glutathione-regulated potassium exporter activity
SynA1544_RS00720	COG0277	FAD linked oxidase domain protein
SynA1544_RS00730	COG0247	lactate metabolic process
SynA1544_RS00740	COG0538	isocitrate dehydrogenase activity
SynA1544_RS00755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SynA1544_RS00765	COG5398	heme oxygenase
SynA1544_RS00775	COG1132	(ABC) transporter
SynA1544_RS00780	COG0438	transferase activity, transferring glycosyl groups
SynA1544_RS00785	COG0438	transferase activity, transferring glycosyl groups
SynA1544_RS00790	COG0438	transferase activity, transferring glycosyl groups
SynA1544_RS00795	COG0438	transferase activity, transferring glycosyl groups
SynA1544_RS00810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynA1544_RS00835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynA1544_RS00840	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynA1544_RS00845	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynA1544_RS00845	COG0517	IMP dehydrogenase activity
SynA1544_RS00850	COG0517	IMP dehydrogenase activity
SynA1544_RS00850	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynA1544_RS00850	COG0617	tRNA 3'-terminal CCA addition
SynA1544_RS00860	COG0709	Synthesizes selenophosphate from selenide and ATP
SynA1544_RS00865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1544_RS00875	COG2274	protein secretion by the type I secretion system
SynA1544_RS00880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynA1544_RS00890	COG1215	transferase activity, transferring glycosyl groups
SynA1544_RS00895	COG0124	histidyl-tRNA synthetase
SynA1544_RS00900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1544_RS00905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynA1544_RS00935	COG4447	cellulose binding
SynA1544_RS00940	COG1773	rubredoxin
SynA1544_RS00945	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1544_RS00950	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1544_RS00955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1544_RS00960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynA1544_RS00965	COG3842	ATPase activity
SynA1544_RS00975	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1544_RS00975	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1544_RS00995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SynA1544_RS01000	COG0494	nUDIX hydrolase
SynA1544_RS01005	COG0415	Belongs to the DNA photolyase family
SynA1544_RS01035	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynA1544_RS01040	COG0131	Imidazoleglycerol-phosphate dehydratase
SynA1544_RS01045	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynA1544_RS01060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynA1544_RS01080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1544_RS01085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1544_RS01095	COG0354	folic acid binding
SynA1544_RS01100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynA1544_RS01115	COG1253	flavin adenine dinucleotide binding
SynA1544_RS01135	COG0673	inositol 2-dehydrogenase activity
SynA1544_RS01145	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SynA1544_RS01155	COG0343	queuine tRNA-ribosyltransferase activity
SynA1544_RS01160	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynA1544_RS01180	COG0138	bifunctional purine biosynthesis protein purh
SynA1544_RS01195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynA1544_RS01200	COG0004	ammonium transporteR
SynA1544_RS01205	COG1489	DNA binding
SynA1544_RS01210	COG0728	peptidoglycan biosynthetic process
SynA1544_RS01235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynA1544_RS01240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1544_RS01245	COG1058	Belongs to the CinA family
SynA1544_RS01245	COG1546	Belongs to the CinA family
SynA1544_RS01250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynA1544_RS01255	COG0066	3-isopropylmalate dehydratase activity
SynA1544_RS01290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA1544_RS01295	COG0193	aminoacyl-tRNA hydrolase activity
SynA1544_RS01310	COG4372	Transposase
SynA1544_RS01315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1544_RS01320	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynA1544_RS01330	COG0717	Belongs to the dCTP deaminase family
SynA1544_RS01340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA1544_RS01345	COG0741	lytic transglycosylase activity
SynA1544_RS01350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1544_RS01365	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynA1544_RS01385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynA1544_RS01405	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1544_RS01425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynA1544_RS01430	COG2094	Belongs to the DNA glycosylase MPG family
SynA1544_RS01435	COG0540	Belongs to the ATCase OTCase family
SynA1544_RS01465	COG3536	Protein conserved in bacteria
SynA1544_RS01470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynA1544_RS01485	COG0529	Catalyzes the synthesis of activated sulfate
SynA1544_RS01485	COG2046	Belongs to the sulfate adenylyltransferase family
SynA1544_RS01490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1544_RS01505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynA1544_RS01530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1544_RS01540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1544_RS01545	COG0436	Aminotransferase
SynA1544_RS01555	COG1530	ribonuclease E activity
SynA1544_RS01560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynA1544_RS01575	COG2226	methyltransferase
SynA1544_RS01580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynA1544_RS01585	COG0051	transcription antitermination factor activity, RNA binding
SynA1544_RS01590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynA1544_RS01595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynA1544_RS01600	COG0049	tRNA binding
SynA1544_RS01605	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynA1544_RS01610	COG0316	Belongs to the HesB IscA family
SynA1544_RS01620	COG0067	glutamate synthase
SynA1544_RS01620	COG0070	glutamate synthase
SynA1544_RS01620	COG0069	glutamate synthase activity
SynA1544_RS01630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1544_RS01650	COG2885	chlorophyll binding
SynA1544_RS01655	COG2885	chlorophyll binding
SynA1544_RS01690	COG0463	Glycosyl transferase, family 2
SynA1544_RS01710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynA1544_RS01720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynA1544_RS01725	COG0254	rRNA binding
SynA1544_RS01730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynA1544_RS01735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynA1544_RS01740	COG0101	tRNA pseudouridine synthase activity
SynA1544_RS01745	COG0203	ribosomal protein L17
SynA1544_RS01750	COG0202	RNA polymerase activity
SynA1544_RS01755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynA1544_RS01760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynA1544_RS01765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynA1544_RS01770	COG0563	adenylate kinase activity
SynA1544_RS01775	COG0201	protein transport
SynA1544_RS01780	COG0200	Binds to the 23S rRNA
SynA1544_RS01785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynA1544_RS01790	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynA1544_RS01795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynA1544_RS01800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynA1544_RS01805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynA1544_RS01810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynA1544_RS01815	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynA1544_RS01820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynA1544_RS01825	COG0255	Belongs to the universal ribosomal protein uL29 family
SynA1544_RS01830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynA1544_RS01835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynA1544_RS01840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynA1544_RS01845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynA1544_RS01850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynA1544_RS01855	COG0089	rRNA binding
SynA1544_RS01860	COG0088	Forms part of the polypeptide exit tunnel
SynA1544_RS01865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynA1544_RS01880	COG3854	ATPases associated with a variety of cellular activities
SynA1544_RS01895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynA1544_RS01920	COG1233	COG1233 Phytoene dehydrogenase and related
SynA1544_RS01945	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynA1544_RS01950	COG1606	tRNA processing
SynA1544_RS01955	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynA1544_RS01960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynA1544_RS01975	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynA1544_RS01980	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynA1544_RS01985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynA1544_RS02000	COG0772	Belongs to the SEDS family
SynA1544_RS02005	COG0489	protein tyrosine kinase activity
SynA1544_RS02010	COG0408	coproporphyrinogen oxidase activity
SynA1544_RS02030	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynA1544_RS02070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynA1544_RS02075	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA1544_RS02080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynA1544_RS02080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynA1544_RS02085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynA1544_RS02090	COG1413	lyase activity
SynA1544_RS02200	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1544_RS02250	COG1070	Carbohydrate kinase
SynA1544_RS02255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynA1544_RS02265	COG0539	negative regulation of cytoplasmic translation
SynA1544_RS02270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynA1544_RS02295	COG0589	response to stress
SynA1544_RS02305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1544_RS02305	COG0758	DNA mediated transformation
SynA1544_RS02310	COG2890	protein-(glutamine-N5) methyltransferase activity
SynA1544_RS02315	COG0009	L-threonylcarbamoyladenylate synthase
SynA1544_RS02335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynA1544_RS02340	COG2894	cell division
SynA1544_RS02345	COG0850	regulation of cytokinetic process
SynA1544_RS02350	COG1078	dGTPase activity
SynA1544_RS02355	COG0793	Belongs to the peptidase S41A family
SynA1544_RS02360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1544_RS02365	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1544_RS02430	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynA1544_RS02435	COG0235	Class ii aldolase
SynA1544_RS02440	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynA1544_RS02445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynA1544_RS02460	COG0514	ATP-dependent DNA helicase (RecQ)
SynA1544_RS02470	COG1012	belongs to the aldehyde dehydrogenase family
SynA1544_RS02480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynA1544_RS02505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynA1544_RS02515	COG0659	secondary active sulfate transmembrane transporter activity
SynA1544_RS02520	COG4243	Vitamin k epoxide reductase
SynA1544_RS02525	COG0484	heat shock protein binding
SynA1544_RS02530	COG0113	porphobilinogen synthase activity
SynA1544_RS02540	COG1193	negative regulation of DNA recombination
SynA1544_RS02545	COG3842	ATPase activity
SynA1544_RS02550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynA1544_RS02565	COG0488	(ABC) transporter
SynA1544_RS02575	COG0435	Glutathione S-transferase
SynA1544_RS02580	COG2988	succinylglutamate desuccinylase activity
SynA1544_RS02935	COG1061	Type III restriction enzyme res subunit
SynA1544_RS03025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynA1544_RS03045	COG1185	polyribonucleotide nucleotidyltransferase activity
SynA1544_RS03050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynA1544_RS03055	COG0750	zinc metalloprotease
SynA1544_RS03060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynA1544_RS03070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1544_RS03080	COG0706	membrane insertase activity
SynA1544_RS03090	COG0594	ribonuclease P activity
SynA1544_RS03095	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynA1544_RS03110	COG0616	signal peptide processing
SynA1544_RS03115	COG0697	spore germination
SynA1544_RS03125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynA1544_RS03140	COG1842	Phage shock protein A
SynA1544_RS03145	COG3118	belongs to the thioredoxin family
SynA1544_RS03150	COG0436	Aminotransferase
SynA1544_RS03155	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynA1544_RS03155	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynA1544_RS03160	COG0739	heme binding
SynA1544_RS03165	COG0745	RESPONSE REGULATOR receiver
SynA1544_RS03180	COG2205	protein histidine kinase activity
SynA1544_RS03190	COG0577	efflux transmembrane transporter activity
SynA1544_RS03190	COG1136	(ABC) transporter
SynA1544_RS03195	COG1007	ATP synthesis coupled electron transport
SynA1544_RS03200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynA1544_RS03215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynA1544_RS03245	COG1845	cytochrome c oxidase, subunit III
SynA1544_RS03255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynA1544_RS03260	COG1612	heme a metabolic process
SynA1544_RS03265	COG0109	protoheme IX farnesyltransferase activity
SynA1544_RS03290	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynA1544_RS03305	COG1028	Short-chain dehydrogenase reductase Sdr
SynA1544_RS03320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynA1544_RS03325	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1544_RS03330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1544_RS03335	COG0248	Ppx GppA phosphatase
SynA1544_RS03355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynA1544_RS03360	COG0739	heme binding
SynA1544_RS03365	COG0723	plastoquinol--plastocyanin reductase activity
SynA1544_RS03375	COG0805	protein transport
SynA1544_RS03380	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynA1544_RS03385	COG0194	GDP metabolic process
SynA1544_RS03400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynA1544_RS03405	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1544_RS03415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynA1544_RS03435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1544_RS03455	COG0335	large ribosomal subunit rRNA binding
SynA1544_RS03465	COG0024	Methionine aminopeptidase
SynA1544_RS03470	COG0300	oxidoreductase activity
SynA1544_RS03470	COG3000	fatty acid hydroxylase
SynA1544_RS03480	COG0857	belongs to the CobB CobQ family
SynA1544_RS03495	COG1666	GTP binding
SynA1544_RS03520	COG1201	RNA secondary structure unwinding
SynA1544_RS03530	COG0202	RNA polymerase activity
SynA1544_RS03540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SynA1544_RS03545	COG0732	type I restriction modification DNA specificity domain
SynA1544_RS03555	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SynA1544_RS03565	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynA1544_RS03575	COG0295	cytidine deaminase activity
SynA1544_RS03585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynA1544_RS03590	COG0277	FAD linked oxidase domain protein
SynA1544_RS03595	COG0708	Exodeoxyribonuclease III
SynA1544_RS03615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1544_RS03620	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynA1544_RS03640	COG3842	ATPase activity
SynA1544_RS03650	COG0523	cobalamin synthesis protein
SynA1544_RS03655	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynA1544_RS03660	COG0432	Pfam Uncharacterised protein family UPF0047
SynA1544_RS03675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1544_RS03690	COG0181	hydroxymethylbilane synthase activity
SynA1544_RS03700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1544_RS03705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynA1544_RS03715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynA1544_RS03745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynA1544_RS03750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynA1544_RS03760	COG0442	prolyl-tRNA aminoacylation
SynA1544_RS03775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1544_RS03805	COG0588	phosphoglycerate mutase activity
SynA1544_RS03820	COG0768	penicillin binding
SynA1544_RS03825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynA1544_RS03840	COG0415	Belongs to the DNA photolyase family
SynA1544_RS03850	COG0233	cytoplasmic translational termination
SynA1544_RS03855	COG0528	UMP kinase activity
SynA1544_RS03870	COG2226	methyltransferase
SynA1544_RS03880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1544_RS03885	COG0028	Belongs to the TPP enzyme family
SynA1544_RS03905	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynA1544_RS03920	COG0539	negative regulation of cytoplasmic translation
SynA1544_RS03930	COG3396	Phenylacetate-CoA oxygenase
SynA1544_RS03935	COG5322	oxidoreductase activity
SynA1544_RS03940	COG0825	malonyl-CoA metabolic process
SynA1544_RS03950	COG0302	gtp cyclohydrolase
SynA1544_RS03955	COG0135	phosphoribosylanthranilate isomerase activity
SynA1544_RS03960	COG1994	Peptidase M50
SynA1544_RS03960	COG0517	IMP dehydrogenase activity
SynA1544_RS03965	COG0095	Lipoate-protein ligase
SynA1544_RS03970	COG0730	response to heat
SynA1544_RS03995	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynA1544_RS04000	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1544_RS04005	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1544_RS04020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1544_RS04025	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1544_RS04030	COG1850	ribulose-bisphosphate carboxylase activity
SynA1544_RS04035	COG4451	ribulose bisphosphate carboxylase, small
SynA1544_RS04060	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1544_RS04065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1544_RS04070	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1544_RS04100	COG1492	cobalamin metabolic process
SynA1544_RS04110	COG0424	maF-like protein
SynA1544_RS04120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynA1544_RS04125	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynA1544_RS04135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynA1544_RS04165	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynA1544_RS04170	COG0579	oxidoreductase
SynA1544_RS04180	COG0481	GTPase activity
SynA1544_RS04220	COG0745	RESPONSE REGULATOR receiver
SynA1544_RS04250	COG5002	protein histidine kinase activity
SynA1544_RS04250	COG3850	Histidine kinase
SynA1544_RS04255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SynA1544_RS04270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1544_RS04275	COG3695	enzyme binding
SynA1544_RS04280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynA1544_RS04280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1544_RS04285	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynA1544_RS04290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1544_RS04300	COG0107	imidazoleglycerol-phosphate synthase activity
SynA1544_RS04305	COG2226	methyltransferase
SynA1544_RS04315	COG0752	glycyl-tRNA synthetase alpha subunit
SynA1544_RS04330	COG0582	viral genome integration into host DNA
SynA1544_RS04400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynA1544_RS04405	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynA1544_RS04410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynA1544_RS04415	COG0740	serine-type endopeptidase activity
SynA1544_RS04420	COG0740	serine-type endopeptidase activity
SynA1544_RS04425	COG4956	integral membrane protein (PIN domain superfamily)
SynA1544_RS04430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynA1544_RS04435	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynA1544_RS04445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynA1544_RS04460	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynA1544_RS04465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1544_RS04470	COG4948	Mandelate Racemase Muconate Lactonizing
SynA1544_RS04500	COG1357	PFAM Pentapeptide repeats (8 copies)
SynA1544_RS04505	COG0285	dihydrofolate synthase activity
SynA1544_RS04510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA1544_RS04515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA1544_RS04520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynA1544_RS04535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1544_RS04540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1544_RS04545	COG0134	indole-3-glycerol-phosphate synthase activity
SynA1544_RS04550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynA1544_RS04565	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynA1544_RS04570	COG0482	sulfurtransferase activity
SynA1544_RS04575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynA1544_RS04575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynA1544_RS04580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1544_RS04585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynA1544_RS04595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynA1544_RS04600	COG0228	four-way junction DNA binding
SynA1544_RS04605	COG1702	phosphate starvation-inducible protein PhoH
SynA1544_RS04610	COG0670	Belongs to the BI1 family
SynA1544_RS04625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynA1544_RS04640	COG0336	Belongs to the RNA methyltransferase TrmD family
SynA1544_RS04660	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynA1544_RS04670	COG1691	(AIR) carboxylase
SynA1544_RS04690	COG0352	thiamine-phosphate diphosphorylase activity
SynA1544_RS04695	COG0196	riboflavin kinase activity
SynA1544_RS04705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynA1544_RS04710	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynA1544_RS04715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1544_RS04760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1544_RS04760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1544_RS04770	COG2135	peptidase activity
SynA1544_RS04775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1544_RS04780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynA1544_RS04795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1544_RS04835	COG0582	viral genome integration into host DNA
SynA1544_RS04865	COG0251	oxidation-reduction process
SynA1544_RS04870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynA1544_RS04875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynA1544_RS04880	COG1132	(ABC) transporter
SynA1544_RS04885	COG0456	acetyltransferase
SynA1544_RS04900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1544_RS04905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynA1544_RS04925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1544_RS04935	COG1845	cytochrome c oxidase, subunit III
SynA1544_RS04940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynA1544_RS04945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynA1544_RS04965	COG0659	secondary active sulfate transmembrane transporter activity
SynA1544_RS04970	COG0418	dihydroorotase activity
SynA1544_RS04995	COG0159	tryptophan synthase activity
SynA1544_RS05010	COG2010	Cytochrome c
SynA1544_RS05045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1544_RS05065	COG0140	phosphoribosyl-ATP diphosphatase activity
SynA1544_RS05065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynA1544_RS05075	COG0542	response to heat
SynA1544_RS05105	COG3794	PFAM blue (type 1) copper domain protein
SynA1544_RS05115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynA1544_RS05120	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynA1544_RS05160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynA1544_RS05175	COG0339	signal peptide processing
SynA1544_RS05180	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1544_RS05185	COG0083	homoserine kinase activity
SynA1544_RS05190	COG0837	glucose binding
SynA1544_RS05200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynA1544_RS05215	COG0180	Tryptophanyl-tRNA synthetase
SynA1544_RS05335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynA1544_RS05420	COG1116	anion transmembrane transporter activity
SynA1544_RS05425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA1544_RS05440	COG0375	protein maturation
SynA1544_RS05445	COG0010	Belongs to the arginase family
SynA1544_RS05480	COG0484	heat shock protein binding
SynA1544_RS05550	COG0189	ligase activity
SynA1544_RS05550	COG4067	protein conserved in archaea
SynA1544_RS05595	COG2801	Transposase and inactivated derivatives
SynA1544_RS05630	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynA1544_RS05635	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynA1544_RS05715	COG0798	PFAM Bile acid sodium symporter
SynA1544_RS05735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SynA1544_RS05765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1544_RS05790	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynA1544_RS05805	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynA1544_RS05830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynA1544_RS05835	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SynA1544_RS05845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynA1544_RS05850	COG3829	transcription factor binding
SynA1544_RS05880	COG2132	Multicopper oxidase
SynA1544_RS05895	COG5002	protein histidine kinase activity
SynA1544_RS05935	COG0681	Belongs to the peptidase S26 family
SynA1544_RS05940	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynA1544_RS05945	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynA1544_RS05950	COG1376	ErfK ybiS ycfS ynhG family protein
SynA1544_RS05955	COG0297	glycogen (starch) synthase activity
SynA1544_RS05965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynA1544_RS05970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynA1544_RS05980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynA1544_RS05985	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynA1544_RS05990	COG2045	Belongs to the ComB family
SynA1544_RS06000	COG0860	N-Acetylmuramoyl-L-alanine amidase
SynA1544_RS06005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynA1544_RS06010	COG0142	geranyltranstransferase activity
SynA1544_RS06015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynA1544_RS06020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynA1544_RS06030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1544_RS06035	COG2176	DNA-directed DNA polymerase activity
SynA1544_RS06055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1544_RS06075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1544_RS06090	COG1132	(ABC) transporter
SynA1544_RS06095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1544_RS06100	COG0505	Belongs to the CarA family
SynA1544_RS06110	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynA1544_RS06115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1544_RS06125	COG0154	amidase activity
SynA1544_RS06130	COG0587	DNA-directed DNA polymerase activity
SynA1544_RS06140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynA1544_RS06145	COG0632	four-way junction helicase activity
SynA1544_RS06160	COG0358	DNA primase activity
SynA1544_RS06220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynA1544_RS06235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1544_RS06260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynA1544_RS06275	COG0792	nuclease activity
SynA1544_RS06280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynA1544_RS06285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynA1544_RS06295	COG0022	dehydrogenase e1 component
SynA1544_RS06295	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA1544_RS06300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1544_RS06305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1544_RS06330	COG0628	permease
SynA1544_RS06340	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynA1544_RS06345	COG0515	serine threonine protein kinase
SynA1544_RS06370	COG2226	methyltransferase
SynA1544_RS06375	COG0174	glutamine synthetase
SynA1544_RS06385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynA1544_RS06405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynA1544_RS06425	COG0612	Peptidase, M16
SynA1544_RS06455	COG1216	Glycosyl transferase, family 2
SynA1544_RS06460	COG0052	Belongs to the universal ribosomal protein uS2 family
SynA1544_RS06465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynA1544_RS06475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynA1544_RS06480	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynA1544_RS06485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1544_RS06490	COG0751	glycine-tRNA ligase activity
SynA1544_RS06500	COG0644	oxidoreductase
SynA1544_RS06510	COG0826	peptidase U32
SynA1544_RS06515	COG1217	gtp-binding protein TYPA
SynA1544_RS06540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynA1544_RS06550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynA1544_RS06555	COG1494	fructose-1,6-bisphosphatase
SynA1544_RS06560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynA1544_RS06565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1544_RS06570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynA1544_RS06575	COG0363	glucosamine-6-phosphate deaminase activity
SynA1544_RS06590	COG0129	dihydroxy-acid dehydratase activity
SynA1544_RS06600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynA1544_RS06605	COG1357	PFAM Pentapeptide repeats (8 copies)
SynA1544_RS06635	COG0300	oxidoreductase activity
SynA1544_RS06665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynA1544_RS06675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynA1544_RS06690	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynA1544_RS06695	COG1122	ATPase activity
SynA1544_RS06715	COG1836	PFAM Integral membrane protein DUF92
SynA1544_RS06745	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynA1544_RS06750	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynA1544_RS06755	COG0436	Aminotransferase
SynA1544_RS06765	COG1573	uracil-dna glycosylase
SynA1544_RS06770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynA1544_RS06775	COG0793	Belongs to the peptidase S41A family
SynA1544_RS06785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynA1544_RS06810	COG0861	Integral membrane protein TerC family
SynA1544_RS06825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynA1544_RS06840	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynA1544_RS06855	COG0163	prenyltransferase activity
SynA1544_RS06860	COG0557	exoribonuclease II activity
SynA1544_RS06870	COG2119	membrane
SynA1544_RS06885	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynA1544_RS06885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynA1544_RS06890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynA1544_RS06905	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynA1544_RS06910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1544_RS06915	COG1615	UPF0182 protein
SynA1544_RS06920	COG0450	alkyl hydroperoxide reductase
SynA1544_RS06935	COG0739	heme binding
SynA1544_RS06940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynA1544_RS06975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA1544_RS06985	COG0557	exoribonuclease II activity
SynA1544_RS06990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynA1544_RS06995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynA1544_RS07000	COG0072	phenylalanine-tRNA ligase activity
SynA1544_RS07005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynA1544_RS07045	COG2385	sporulation resulting in formation of a cellular spore
SynA1544_RS07070	COG1410	methionine synthase
SynA1544_RS07070	COG0646	methionine synthase
SynA1544_RS07075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynA1544_RS07095	COG1981	membrane
SynA1544_RS07100	COG3046	protein related to deoxyribodipyrimidine photolyase
SynA1544_RS07110	COG0322	excinuclease ABC activity
SynA1544_RS07120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynA1544_RS07130	COG2027	D-alanyl-D-alanine carboxypeptidase
SynA1544_RS07145	COG1104	cysteine desulfurase activity
SynA1544_RS07150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynA1544_RS07160	COG0495	leucyl-tRNA aminoacylation
SynA1544_RS07165	COG0166	Belongs to the GPI family
SynA1544_RS07175	COG2095	MarC family integral membrane protein
SynA1544_RS07235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynA1544_RS07240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynA1544_RS07245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1544_RS07245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1544_RS07250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1544_RS07255	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynA1544_RS07260	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynA1544_RS07270	COG0484	heat shock protein binding
SynA1544_RS07275	COG0443	Heat shock 70 kDa protein
SynA1544_RS07280	COG0573	inorganic phosphate transmembrane transporter activity
SynA1544_RS07285	COG0581	inorganic phosphate transmembrane transporter activity
SynA1544_RS07290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynA1544_RS07305	COG0483	inositol monophosphate 1-phosphatase activity
SynA1544_RS07310	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynA1544_RS07320	COG0326	Molecular chaperone. Has ATPase activity
SynA1544_RS07325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynA1544_RS07330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1544_RS07335	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynA1544_RS07340	COG1653	transport
SynA1544_RS07345	COG1175	transmembrane transport
SynA1544_RS07360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA1544_RS07385	COG0446	pyridine nucleotide-disulphide oxidoreductase
SynA1544_RS07390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynA1544_RS07395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynA1544_RS07405	COG0762	integral membrane protein
SynA1544_RS07420	COG0469	pyruvate kinase activity
SynA1544_RS07425	COG1136	(ABC) transporter
SynA1544_RS07425	COG0577	efflux transmembrane transporter activity
SynA1544_RS07430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1544_RS07445	COG0740	serine-type endopeptidase activity
SynA1544_RS07465	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1544_RS07500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynA1544_RS07505	COG1175	transmembrane transport
SynA1544_RS07510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynA1544_RS07540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SynA1544_RS07565	COG1793	dna ligase
SynA1544_RS07570	COG1201	RNA secondary structure unwinding
SynA1544_RS07650	COG2226	methyltransferase
SynA1544_RS07700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1544_RS07710	COG1121	(ABC) transporter
SynA1544_RS07715	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA1544_RS07720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynA1544_RS07740	COG0572	uridine kinase
SynA1544_RS07830	COG0724	RNA recognition motif
SynA1544_RS07840	COG0463	Glycosyl transferase, family 2
SynA1544_RS07925	COG2124	cytochrome p450
SynA1544_RS08030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynA1544_RS08050	COG1111	helicase
SynA1544_RS08050	COG1205	dead DEAH box helicase
SynA1544_RS08110	COG0537	adenosine 5'-monophosphoramidase activity
SynA1544_RS08135	COG1598	PFAM Uncharacterised protein family UPF0150
SynA1544_RS08195	COG1051	belongs to the nudix hydrolase family
SynA1544_RS08295	COG2361	Protein of unknown function DUF86
SynA1544_RS08320	COG0668	transmembrane transport
SynA1544_RS08325	COG2124	cytochrome p450
SynA1544_RS08330	COG1454	alcohol dehydrogenase
SynA1544_RS08340	COG2124	cytochrome p450
SynA1544_RS08345	COG2124	cytochrome p450
SynA1544_RS08410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynA1544_RS08455	COG0590	tRNA wobble adenosine to inosine editing
SynA1544_RS08505	COG0405	Gamma-glutamyltransferase
SynA1544_RS08550	COG2197	response regulator
SynA1544_RS08615	COG3659	wide pore channel activity
SynA1544_RS08625	COG3128	pkhd-type hydroxylase
SynA1544_RS08630	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA1544_RS08640	COG3659	wide pore channel activity
SynA1544_RS08695	COG0701	Predicted permease
SynA1544_RS08720	COG1121	(ABC) transporter
SynA1544_RS08725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1544_RS08745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynA1544_RS08765	COG1640	4-alpha-glucanotransferase
SynA1544_RS08775	COG1187	pseudouridine synthase activity
SynA1544_RS08780	COG5002	protein histidine kinase activity
SynA1544_RS08785	COG0745	RESPONSE REGULATOR receiver
SynA1544_RS08795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1544_RS08800	COG1982	Orn Lys Arg decarboxylase major
SynA1544_RS08805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA1544_RS08810	COG0575	Belongs to the CDS family
SynA1544_RS08820	COG2267	carboxylic ester hydrolase activity
SynA1544_RS08825	COG0371	Dehydrogenase
SynA1544_RS08830	COG0542	response to heat
SynA1544_RS08840	COG0019	diaminopimelate decarboxylase activity
SynA1544_RS08845	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynA1544_RS08850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynA1544_RS08855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynA1544_RS08865	COG1054	Belongs to the UPF0176 family
SynA1544_RS08880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1544_RS08885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynA1544_RS08900	COG0475	glutathione-regulated potassium exporter activity
SynA1544_RS08900	COG0589	response to stress
SynA1544_RS08905	COG1132	(ABC) transporter
SynA1544_RS08915	COG0724	RNA recognition motif
SynA1544_RS08930	COG0513	Belongs to the DEAD box helicase family
SynA1544_RS08940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA1544_RS08955	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynA1544_RS08975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynA1544_RS08990	COG0271	Belongs to the BolA IbaG family
SynA1544_RS08995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynA1544_RS09005	COG0745	RESPONSE REGULATOR receiver
SynA1544_RS09035	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynA1544_RS09045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynA1544_RS09130	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynA1544_RS09235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynA1544_RS09250	COG0735	belongs to the Fur family
SynA1544_RS09325	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynA1544_RS09355	COG1126	abc transporter atp-binding protein
SynA1544_RS09360	COG0765	amino acid transport
SynA1544_RS09365	COG4597	amino acid ABC transporter
SynA1544_RS09370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynA1544_RS09380	COG0659	secondary active sulfate transmembrane transporter activity
SynA1544_RS09420	COG0799	negative regulation of ribosome biogenesis
SynA1544_RS09430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynA1544_RS09440	COG1115	amino acid carrier protein
SynA1544_RS09450	COG1132	(ABC) transporter
SynA1544_RS09460	COG0149	triose-phosphate isomerase activity
SynA1544_RS09465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynA1544_RS09475	COG1429	ligase activity, forming nitrogen-metal bonds
SynA1544_RS09480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynA1544_RS09490	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1544_RS09495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynA1544_RS09505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA1544_RS09555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynA1544_RS09575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1544_RS09580	COG0640	Transcriptional regulator
SynA1544_RS09590	COG0668	transmembrane transport
SynA1544_RS09605	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1544_RS09610	COG0047	phosphoribosylformylglycinamidine synthase activity
SynA1544_RS09615	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1544_RS09625	COG0191	fructose-bisphosphate aldolase activity
SynA1544_RS09630	COG0673	inositol 2-dehydrogenase activity
SynA1544_RS09640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynA1544_RS09645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynA1544_RS09655	COG3954	Phosphoribulokinase
SynA1544_RS09660	COG0473	3-isopropylmalate dehydrogenase activity
SynA1544_RS09665	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1544_RS09670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynA1544_RS09685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynA1544_RS09700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA1544_RS09705	COG2197	response regulator
SynA1544_RS09715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynA1544_RS09750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1544_RS09755	COG0717	Belongs to the dCTP deaminase family
SynA1544_RS09800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1544_RS09810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA1544_RS09870	COG0308	aminopeptidase N
SynA1544_RS09885	COG2205	protein histidine kinase activity
SynA1544_RS09900	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SynA1544_RS09905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynA1544_RS09915	COG1797	cobyrinic acid a,c-diamide synthase activity
SynA1544_RS09920	COG1254	Belongs to the acylphosphatase family
SynA1544_RS09935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA1544_RS09955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynA1544_RS09960	COG1480	7TM receptor with intracellular HD hydrolase
SynA1544_RS09965	COG0564	pseudouridine synthase activity
SynA1544_RS09975	COG0011	TIGRFAM Protein of
SynA1544_RS10005	COG0395	ABC-type sugar transport system, permease component
SynA1544_RS10010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynA1544_RS10015	COG1543	Belongs to the glycosyl hydrolase 57 family
SynA1544_RS10020	COG0644	oxidoreductase
SynA1544_RS10025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1544_RS10030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1544_RS10035	COG0516	GMP reductase activity
SynA1544_RS10040	COG3118	belongs to the thioredoxin family
SynA1544_RS10045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynA1544_RS10050	COG0742	ribosomal rna small subunit methyltransferase
SynA1544_RS10055	COG2010	Cytochrome c
SynA1544_RS10060	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynA1544_RS10075	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1544_RS10080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynA1544_RS10085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynA1544_RS10095	COG2166	iron-sulfur cluster assembly
SynA1544_RS10100	COG0460	homoserine dehydrogenase
SynA1544_RS10110	COG0747	negative chemotaxis
SynA1544_RS10115	COG0601	transmembrane transport
SynA1544_RS10135	COG0012	GTP binding
SynA1544_RS10140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynA1544_RS10145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1544_RS10145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1544_RS10150	COG0215	cysteine-tRNA ligase activity
SynA1544_RS10160	COG0463	Glycosyl transferase, family 2
SynA1544_RS10175	COG0733	neurotransmitter:sodium symporter activity
SynA1544_RS10180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynA1544_RS10185	COG3411	Ferredoxin
SynA1544_RS10235	COG0492	ferredoxin-NADP+ reductase activity
SynA1544_RS10240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynA1544_RS10245	COG1187	pseudouridine synthase activity
SynA1544_RS10250	COG2226	methyltransferase
SynA1544_RS10280	COG0440	acetolactate synthase activity
SynA1544_RS10285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1544_RS10315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1544_RS10320	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynA1544_RS10335	COG1022	Amp-dependent synthetase and ligase
SynA1544_RS10340	COG0321	lipoyl(octanoyl) transferase activity
SynA1544_RS10345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynA1544_RS10350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynA1544_RS10355	COG1381	Involved in DNA repair and RecF pathway recombination
SynA1544_RS10365	COG0438	transferase activity, transferring glycosyl groups
SynA1544_RS10385	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynA1544_RS10395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynA1544_RS10400	COG1799	cell septum assembly
SynA1544_RS10405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynA1544_RS10415	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynA1544_RS10420	COG1160	GTP binding
SynA1544_RS10425	COG1376	ErfK ybiS ycfS ynhG family protein
SynA1544_RS10440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1544_RS10445	COG0438	transferase activity, transferring glycosyl groups
SynA1544_RS10445	COG1216	Glycosyl transferase, family 2
SynA1544_RS10465	COG1088	dTDP-glucose 4,6-dehydratase activity
SynA1544_RS10495	COG0114	fumarate hydratase activity
SynA1544_RS10500	COG4581	dead DEAH box helicase
SynA1544_RS10510	COG0385	Bile acid
SynA1544_RS10515	COG0156	8-amino-7-oxononanoate synthase activity
SynA1544_RS10530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynA1544_RS10545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynA1544_RS10560	COG0357	Ribosomal RNA small subunit methyltransferase G
SynA1544_RS10595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynA1544_RS10600	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1544_RS10605	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1544_RS10610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1544_RS10615	COG0085	RNA polymerase activity
SynA1544_RS10620	COG0084	hydrolase, TatD family'
SynA1544_RS10625	COG0268	Binds directly to 16S ribosomal RNA
SynA1544_RS10630	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynA1544_RS10635	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynA1544_RS10640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1544_RS10655	COG0641	radical SAM
SynA1544_RS10670	COG0779	Required for maturation of 30S ribosomal subunits
SynA1544_RS10675	COG0195	Participates in both transcription termination and antitermination
SynA1544_RS10685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynA1544_RS10715	COG1053	succinate dehydrogenase
SynA1544_RS10735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1544_RS10740	COG0776	regulation of translation
SynA1544_RS10865	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1544_RS10865	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1544_RS10890	COG1487	ribonuclease activity
SynA1544_RS10910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynA1544_RS11010	COG0058	SHG alpha-glucan phosphorylase activity
SynA1544_RS11045	COG2010	Cytochrome c
SynA1544_RS11075	COG0523	cobalamin synthesis protein
SynA1544_RS11140	COG0058	SHG alpha-glucan phosphorylase activity
SynA1544_RS11155	COG2337	Toxic component of a toxin-antitoxin (TA) module
SynA1544_RS11235	COG3550	peptidyl-serine autophosphorylation
SynA1544_RS11250	COG1715	Restriction endonuclease
SynA1544_RS11325	COG4115	mRNA cleavage
SynA1544_RS11495	COG2211	Major facilitator Superfamily
SynA1544_RS11500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynA1544_RS11515	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynA1544_RS11520	COG0284	orotidine-5'-phosphate decarboxylase activity
SynA1544_RS11525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynA1544_RS11550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynA1544_RS11590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1544_RS11600	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1544_RS11605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynA1544_RS11610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynA1544_RS11620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynA1544_RS11630	COG0151	Belongs to the GarS family
SynA1544_RS11635	COG5002	protein histidine kinase activity
SynA1544_RS11640	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynA1544_RS11645	COG4251	negative regulation of phosphorylation
SynA1544_RS11655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynA1544_RS11660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynA1544_RS11670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynA1544_RS11675	COG0217	transcriptional regulatory protein
SynA1544_RS11700	COG0363	glucosamine-6-phosphate deaminase activity
SynA1544_RS11710	COG1234	tRNA 3'-trailer cleavage
SynA1544_RS11715	COG2010	Cytochrome c
SynA1544_RS11730	COG2264	protein methyltransferase activity
SynA1544_RS11735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynA1544_RS11755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynA1544_RS11790	COG0443	Heat shock 70 kDa protein
SynA1544_RS11805	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynA1544_RS11810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynA1544_RS11855	COG0459	protein refolding
SynA1544_RS11860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynA1544_RS11865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynA1544_RS11870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynA1544_RS11885	COG0006	proline dipeptidase activity
SynA1544_RS11890	COG1253	flavin adenine dinucleotide binding
SynA1544_RS11895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynA1544_RS11900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynA1544_RS11905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynA1544_RS11905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1544_RS11915	COG0686	Belongs to the AlaDH PNT family
SynA1544_RS11920	COG3012	SEC-C Motif Domain Protein
SynA1544_RS11925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1544_RS11935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1544_RS11945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynA1544_RS11950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynA1544_RS11955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1544_RS11960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1544_RS11965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1544_RS11970	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1544_RS11975	COG0356	it plays a direct role in the translocation of protons across the membrane
SynA1544_RS11985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1544_RS11990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1544_RS12020	COG0772	Belongs to the SEDS family
SynA1544_RS12035	COG1333	cytochrome c biogenesis protein
SynA1544_RS12050	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynA1544_RS12095	COG1333	cytochrome c biogenesis protein
SynA1544_RS12105	COG2337	Toxic component of a toxin-antitoxin (TA) module
SynA1544_RS12150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynA1544_RS12155	COG0347	Belongs to the P(II) protein family
SynA1544_RS12170	COG0494	nUDIX hydrolase
SynA1544_RS12180	COG0297	glycogen (starch) synthase activity
SynA1544_RS12200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynA1544_RS12250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1544_RS12255	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynA1544_RS12270	COG0489	protein tyrosine kinase activity
SynA1544_RS12290	COG0297	glycogen (starch) synthase activity
SynA1544_RS12360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynA1544_RS12375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA1544_RS12385	COG3562	capsule polysaccharide
SynA1544_RS12395	COG1083	cytidylyl-transferase
SynA1544_RS12415	COG2089	acid synthase
SynA1544_RS12465	COG2095	MarC family integral membrane protein
SynA1544_RS12525	COG0116	Belongs to the methyltransferase superfamily
SynA1544_RS12550	COG1196	nuclear chromosome segregation
SynA1544_RS12560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1544_RS12575	COG0439	Biotin carboxylase
SynA1544_RS12590	COG0515	serine threonine protein kinase
SynA1544_RS12605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1544_RS12610	COG4178	(ABC) transporter
SynA1544_RS12615	COG0537	adenosine 5'-monophosphoramidase activity
SynA1544_RS12620	COG0606	chelatase, subunit chli
SynA1544_RS12640	COG0242	peptide deformylase activity
SynA1544_RS12650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynA1544_RS12655	COG0719	Fe-S assembly protein
SynA1544_RS12660	COG0396	ATPase activity
SynA1544_RS12665	COG0719	Fe-S assembly protein
SynA1544_RS12670	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynA1544_RS12690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1544_RS12710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1544_RS12730	COG0033	Phosphoglucomutase
SynA1544_RS12740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynA1544_RS12750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynA1544_RS12765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1544_RS12770	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynA1544_RS12775	COG0175	sulfate reduction
SynA1544_RS12780	COG1252	NADH dehydrogenase
SynA1544_RS12785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynA1544_RS12790	COG0471	metal ion transport
SynA1544_RS12790	COG3273	potassium ion transport
SynA1544_RS12795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynA1544_RS12800	COG0569	domain protein
SynA1544_RS12805	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynA1544_RS12830	COG0488	(ABC) transporter
SynA1544_RS12840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1544_RS12870	COG1570	exodeoxyribonuclease VII activity
SynA1544_RS12920	COG0483	inositol monophosphate 1-phosphatase activity
SynA1544_RS12935	COG1968	undecaprenyl-diphosphatase activity
SynA1544_RS12945	COG1555	photosystem II stabilization
SynA1544_RS12950	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynA1544_RS12955	COG4243	Vitamin k epoxide reductase
SynA1544_RS12960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1544_RS12975	COG1032	radical SAM domain protein
SynA1544_RS13000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynA1544_RS13025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynA1544_RS13030	COG1472	Belongs to the glycosyl hydrolase 3 family
SynA1544_RS13035	COG0463	Glycosyl transferase, family 2
SynA1544_RS13035	COG0457	Tetratricopeptide repeat
SynA1544_RS13040	COG1587	Uroporphyrinogen-III synthase
SynA1544_RS13055	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1544_RS13060	COG0316	Belongs to the HesB IscA family
SynA1544_RS13085	COG1090	epimerase
SynA1544_RS13100	COG0484	heat shock protein binding
SynA1544_RS13105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1544_RS13110	COG3659	wide pore channel activity
SynA1544_RS13115	COG3659	wide pore channel activity
SynA1544_RS13165	COG1122	ATPase activity
SynA1544_RS13175	COG0745	RESPONSE REGULATOR receiver
SynA1544_RS13190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynA1544_RS13195	COG2217	Heavy metal translocating P-type atpase
SynA1544_RS13200	COG3063	Type IV pilus biogenesis stability protein PilW
SynA1544_RS13205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynA1544_RS13215	COG0416	fatty acid biosynthetic process
SynA1544_RS13220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynA1544_RS13225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynA1544_RS13230	COG0318	PFAM AMP-dependent synthetase and ligase
SynA1544_RS13230	COG0204	Acyl-transferase
SynA1544_RS13240	COG1214	PFAM Peptidase M22, glycoprotease
SynA1544_RS13250	COG0617	tRNA 3'-terminal CCA addition
SynA1544_RS13255	COG0724	RNA recognition motif
SynA1544_RS13260	COG1562	ergosterol biosynthetic process
SynA1544_RS13265	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1544_RS13265	COG0493	'glutamate synthase
SynA1544_RS13280	COG0583	DNA-binding transcription factor activity
SynA1544_RS13290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1544_RS13295	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1544_RS13310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynA1544_RS13320	COG2197	response regulator
SynA1544_RS13330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1544_RS13335	COG0713	ATP synthesis coupled electron transport
SynA1544_RS13340	COG0839	Belongs to the complex I subunit 6 family
SynA1544_RS13345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1544_RS13350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynA1544_RS13355	COG0372	Belongs to the citrate synthase family
SynA1544_RS13370	COG1054	Belongs to the UPF0176 family
SynA1544_RS13375	COG1420	regulation of RNA biosynthetic process
SynA1544_RS13380	COG0133	tryptophan synthase activity
SynA1544_RS13385	COG0023	Translation Initiation Factor
SynA1544_RS13390	COG0529	Catalyzes the synthesis of activated sulfate
SynA1544_RS13415	COG0628	permease
SynA1544_RS13425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynA1544_RS13435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1544_RS13445	COG0564	pseudouridine synthase activity
SynA1544_RS13450	COG0745	RESPONSE REGULATOR receiver
SynA1544_RS13460	COG1104	cysteine desulfurase activity
SynA1544_RS13465	COG0275	rRNA processing
SynA1544_RS13470	COG0649	NAD binding
SynA1544_RS13485	COG0824	Thioesterase
SynA1544_RS13490	COG0318	PFAM AMP-dependent synthetase and ligase
SynA1544_RS13500	COG1575	Belongs to the MenA family. Type 1 subfamily
SynA1544_RS13510	COG0189	ligase activity
SynA1544_RS13515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA1544_RS13530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynA1544_RS13535	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynA1544_RS13550	COG0252	asparaginase activity
SynA1544_RS13555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA1544_RS13565	COG0018	arginyl-trna synthetase
SynA1544_RS13570	COG0157	Belongs to the NadC ModD family
SynA1544_RS13575	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynA1544_RS13585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynA1544_RS13590	COG4172	Belongs to the ABC transporter superfamily
SynA1544_RS13595	COG0564	pseudouridine synthase activity
SynA1544_RS13600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynA1544_RS13605	COG0126	phosphoglycerate kinase activity
SynA1544_RS13625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynA1544_RS13630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA1544_RS13660	COG0167	dihydroorotate dehydrogenase activity
SynA1544_RS13665	COG0328	RNA-DNA hybrid ribonuclease activity
SynA1544_RS13675	COG0222	ribosome binding
SynA1544_RS13680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynA1544_RS13685	COG0081	regulation of translation
SynA1544_RS13690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynA1544_RS13695	COG0250	Participates in transcription elongation, termination and antitermination
SynA1544_RS13700	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynA1544_RS13705	COG0542	response to heat
SynA1544_RS13710	COG0346	lactoylglutathione lyase activity
SynA1544_RS13715	COG0148	phosphopyruvate hydratase activity
SynA1544_RS13720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1544_RS13755	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynA1544_RS13760	COG0237	dephospho-CoA kinase activity
SynA1544_RS13775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1544_RS13780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynA1544_RS13780	COG2022	thiamine diphosphate biosynthetic process
SynA1544_RS13785	COG0105	UTP biosynthetic process
SynA1544_RS13790	COG1166	arginine decarboxylase activity
SynA1544_RS13795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynA1544_RS13805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynA1544_RS13830	COG0426	domain, Protein
SynA1544_RS13830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1544_RS13840	COG0426	domain, Protein
SynA1544_RS13840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1544_RS13845	COG1773	rubredoxin
SynA1544_RS13855	COG1741	Belongs to the pirin family
SynA1544_RS13870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA1544_RS13870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA1544_RS13875	COG0509	glycine decarboxylation via glycine cleavage system
SynA1544_RS13880	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynA1544_RS13890	COG0359	binds to the 23S rRNA
SynA1544_RS13895	COG1372	Participates in initiation and elongation during chromosome replication
SynA1544_RS13895	COG0305	Participates in initiation and elongation during chromosome replication
SynA1544_RS13895	COG0305	Participates in initiation and elongation during chromosome replication
SynA1544_RS13895	COG1372	Participates in initiation and elongation during chromosome replication
SynA1544_RS13900	COG0445	tRNA wobble uridine modification
SynA1544_RS13935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1544_RS13945	COG0398	Pfam SNARE associated Golgi protein
SynA1544_RS13965	COG0525	valine-tRNA ligase activity
SynA1544_RS13995	COG4221	oxidoreductase activity
SynA1544_RS14030	COG3956	TIGRFAM MazG family protein
SynA1544_RS14035	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynA1544_RS14040	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynA1544_RS14045	COG0010	Belongs to the arginase family
SynA1544_RS14060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynA1544_RS14065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynA1544_RS14070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1544_RS14075	COG0504	CTP synthase activity
SynA1544_RS14080	COG0602	queuosine metabolic process
SynA1544_RS14085	COG2084	Dehydrogenase
SynA1544_RS14090	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynA1544_RS14110	COG0366	Alpha amylase catalytic
SynA1544_RS14115	COG0463	Glycosyl transferase, family 2
SynA1544_RS14160	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynA1544_RS14165	COG0830	nickel cation binding
SynA1544_RS14170	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynA1544_RS14175	COG0829	nickel cation binding
SynA1544_RS14180	COG0831	urea catabolic process
SynA1544_RS14185	COG0832	Belongs to the urease beta subunit family
SynA1544_RS14190	COG0804	urea catabolic process
SynA1544_RS14195	COG0519	Catalyzes the synthesis of GMP from XMP
SynA1544_RS14195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynA1544_RS14220	COG0367	asparagine synthase
SynA1544_RS14225	COG0540	Belongs to the ATCase OTCase family
SynA1544_RS14235	COG2308	Evidence 4 Homologs of previously reported genes of
SynA1544_RS14255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynA1544_RS14260	COG0746	molybdenum cofactor guanylyltransferase activity
SynA1544_RS14265	COG2223	nitrite transmembrane transporter activity
SynA1544_RS14270	COG0243	molybdopterin cofactor binding
SynA1544_RS14290	COG0315	cyclic pyranopterin monophosphate synthase activity
SynA1544_RS14310	COG0314	molybdopterin synthase activity
SynA1544_RS14320	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynA1544_RS14325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynA1544_RS14340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1544_RS14350	COG2116	formate transmembrane transporter activity
SynA1544_RS14360	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynA1544_RS14375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1544_RS14390	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynA1544_RS14395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1544_RS14400	COG0170	dolichyl monophosphate biosynthetic process
SynA1544_RS14405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynA1544_RS14410	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynA1544_RS14435	COG0788	formyltetrahydrofolate deformylase activity
SynA1544_RS14450	COG0443	Heat shock 70 kDa protein
SynA1544_RS14455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynA1544_RS14465	COG0360	Binds together with S18 to 16S ribosomal RNA
SynA1544_RS14475	COG0137	argininosuccinate synthase activity
SynA1544_RS14490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1544_RS14515	COG1376	ErfK ybiS ycfS ynhG family protein
SynA1544_RS14520	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynA1544_RS14525	COG0438	transferase activity, transferring glycosyl groups
SynA1544_RS14535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynA1544_RS14540	COG0497	DNA recombination
SynA1544_RS14545	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1544_RS14555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine