locus-tag	class	description
SynA1560_RS00005	COG0592	DNA-directed DNA polymerase activity
SynA1560_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1560_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1560_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynA1560_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1560_RS00055	COG0552	protein localization to endoplasmic reticulum
SynA1560_RS00060	COG2208	phosphoserine phosphatase activity
SynA1560_RS00065	COG0165	Argininosuccinate lyase
SynA1560_RS00070	COG0724	RNA recognition motif
SynA1560_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1560_RS00085	COG2081	HI0933 family
SynA1560_RS00090	COG1459	type II secretion system
SynA1560_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynA1560_RS00105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynA1560_RS00110	COG0484	heat shock protein binding
SynA1560_RS00120	COG1162	GTPase activity
SynA1560_RS00125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynA1560_RS00130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynA1560_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynA1560_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1560_RS00145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynA1560_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1560_RS00155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynA1560_RS00160	COG0511	ligase activity, forming carbon-carbon bonds
SynA1560_RS00165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynA1560_RS00225	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynA1560_RS00230	COG0519	Catalyzes the synthesis of GMP from XMP
SynA1560_RS00230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynA1560_RS00250	COG0438	transferase activity, transferring glycosyl groups
SynA1560_RS00250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynA1560_RS00255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1560_RS00265	COG2022	thiamine diphosphate biosynthetic process
SynA1560_RS00280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynA1560_RS00285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynA1560_RS00290	COG2385	sporulation resulting in formation of a cellular spore
SynA1560_RS00295	COG1215	transferase activity, transferring glycosyl groups
SynA1560_RS00300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynA1560_RS00315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynA1560_RS00320	COG0740	serine-type endopeptidase activity
SynA1560_RS00325	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynA1560_RS00330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynA1560_RS00335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynA1560_RS00340	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynA1560_RS00350	COG0037	tRNA processing
SynA1560_RS00375	COG0556	nucleotide-excision repair
SynA1560_RS00380	COG0527	aspartate kinase activity
SynA1560_RS00390	COG2082	Precorrin-8x methylmutase
SynA1560_RS00400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynA1560_RS00410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynA1560_RS00425	COG1086	Polysaccharide biosynthesis protein
SynA1560_RS00430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SynA1560_RS00435	COG1083	cytidylyl-transferase
SynA1560_RS00440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SynA1560_RS00455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynA1560_RS00460	COG2089	acid synthase
SynA1560_RS00470	COG2192	nodulation
SynA1560_RS00510	COG1091	dTDP-4-dehydrorhamnose reductase activity
SynA1560_RS00515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynA1560_RS00525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1560_RS00530	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynA1560_RS00575	COG0859	PFAM glycosyl transferase family 9
SynA1560_RS00595	COG0438	transferase activity, transferring glycosyl groups
SynA1560_RS00605	COG0438	transferase activity, transferring glycosyl groups
SynA1560_RS00655	COG0297	glycogen (starch) synthase activity
SynA1560_RS00670	COG1216	Glycosyl transferase, family 2
SynA1560_RS00675	COG0438	transferase activity, transferring glycosyl groups
SynA1560_RS00710	COG0653	protein targeting
SynA1560_RS00715	COG1045	serine acetyltransferase
SynA1560_RS00720	COG1725	Transcriptional regulator
SynA1560_RS00730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynA1560_RS00735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynA1560_RS00740	COG1372	Participates in initiation and elongation during chromosome replication
SynA1560_RS00740	COG0187	DNA topoisomerase II activity
SynA1560_RS00750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1560_RS00755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1560_RS00765	COG0386	Belongs to the glutathione peroxidase family
SynA1560_RS00770	COG2239	Acts as a magnesium transporter
SynA1560_RS00775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1560_RS00785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynA1560_RS00790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynA1560_RS00810	COG4638	Rieske (2fe-2S)
SynA1560_RS00815	COG1116	anion transmembrane transporter activity
SynA1560_RS00820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA1560_RS00835	COG0375	protein maturation
SynA1560_RS00840	COG0010	Belongs to the arginase family
SynA1560_RS00850	COG1194	a g-specific adenine glycosylase
SynA1560_RS00855	COG4413	Urea transporter
SynA1560_RS00880	COG0802	atpase or kinase
SynA1560_RS00885	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynA1560_RS00890	COG0586	Pfam SNARE associated Golgi protein
SynA1560_RS00895	COG0629	single-stranded DNA binding
SynA1560_RS00925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynA1560_RS00945	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynA1560_RS00950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynA1560_RS00955	COG0515	serine threonine protein kinase
SynA1560_RS00960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynA1560_RS00965	COG2255	four-way junction helicase activity
SynA1560_RS00975	COG1473	amidohydrolase
SynA1560_RS00990	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynA1560_RS01005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1560_RS01010	COG0463	Glycosyl transferase, family 2
SynA1560_RS01020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynA1560_RS01025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynA1560_RS01030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA1560_RS01035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1560_RS01040	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynA1560_RS01045	COG1088	dTDP-glucose 4,6-dehydratase activity
SynA1560_RS01050	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynA1560_RS01050	COG0662	Cupin 2, conserved barrel domain protein
SynA1560_RS01055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynA1560_RS01065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1560_RS01070	COG0571	ribonuclease III activity
SynA1560_RS01100	COG0058	SHG alpha-glucan phosphorylase activity
SynA1560_RS01105	COG0475	glutathione-regulated potassium exporter activity
SynA1560_RS01125	COG0277	FAD linked oxidase domain protein
SynA1560_RS01135	COG0247	lactate metabolic process
SynA1560_RS01140	COG0538	isocitrate dehydrogenase activity
SynA1560_RS01145	COG0463	Glycosyl transferase, family 2
SynA1560_RS01165	COG5398	heme oxygenase
SynA1560_RS01180	COG0438	transferase activity, transferring glycosyl groups
SynA1560_RS01185	COG0438	transferase activity, transferring glycosyl groups
SynA1560_RS01190	COG0438	transferase activity, transferring glycosyl groups
SynA1560_RS01195	COG0438	transferase activity, transferring glycosyl groups
SynA1560_RS01205	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynA1560_RS01215	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynA1560_RS01225	COG1215	transferase activity, transferring glycosyl groups
SynA1560_RS01230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynA1560_RS01230	COG0517	IMP dehydrogenase activity
SynA1560_RS01230	COG0617	tRNA 3'-terminal CCA addition
SynA1560_RS01235	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynA1560_RS01240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynA1560_RS01240	COG0517	IMP dehydrogenase activity
SynA1560_RS01255	COG0709	Synthesizes selenophosphate from selenide and ATP
SynA1560_RS01260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1560_RS01265	COG0124	histidyl-tRNA synthetase
SynA1560_RS01270	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynA1560_RS01300	COG4447	cellulose binding
SynA1560_RS01305	COG1773	rubredoxin
SynA1560_RS01310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1560_RS01315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1560_RS01320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1560_RS01325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynA1560_RS01330	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SynA1560_RS01335	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SynA1560_RS01340	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1560_RS01340	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1560_RS01355	COG0494	nUDIX hydrolase
SynA1560_RS01360	COG0415	Belongs to the DNA photolyase family
SynA1560_RS01390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynA1560_RS01400	COG0131	Imidazoleglycerol-phosphate dehydratase
SynA1560_RS01405	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynA1560_RS01415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynA1560_RS01435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1560_RS01440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1560_RS01455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynA1560_RS01470	COG1253	flavin adenine dinucleotide binding
SynA1560_RS01495	COG0343	queuine tRNA-ribosyltransferase activity
SynA1560_RS01500	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynA1560_RS01505	COG2205	protein histidine kinase activity
SynA1560_RS01520	COG0138	bifunctional purine biosynthesis protein purh
SynA1560_RS01540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynA1560_RS01545	COG0004	ammonium transporteR
SynA1560_RS01550	COG1489	DNA binding
SynA1560_RS01555	COG0728	peptidoglycan biosynthetic process
SynA1560_RS01580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynA1560_RS01585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1560_RS01590	COG1546	Belongs to the CinA family
SynA1560_RS01590	COG1058	Belongs to the CinA family
SynA1560_RS01595	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynA1560_RS01600	COG0066	3-isopropylmalate dehydratase activity
SynA1560_RS01635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA1560_RS01640	COG0193	aminoacyl-tRNA hydrolase activity
SynA1560_RS01655	COG4372	Transposase
SynA1560_RS01660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1560_RS01665	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynA1560_RS01675	COG0717	Belongs to the dCTP deaminase family
SynA1560_RS01685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA1560_RS01705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1560_RS01720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynA1560_RS01740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynA1560_RS01760	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1560_RS01775	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynA1560_RS01810	COG2094	Belongs to the DNA glycosylase MPG family
SynA1560_RS01815	COG0540	Belongs to the ATCase OTCase family
SynA1560_RS01840	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1560_RS01850	COG3536	Protein conserved in bacteria
SynA1560_RS01855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynA1560_RS01870	COG2046	Belongs to the sulfate adenylyltransferase family
SynA1560_RS01870	COG0529	Catalyzes the synthesis of activated sulfate
SynA1560_RS01875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1560_RS01890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynA1560_RS01900	COG0385	Bile acid
SynA1560_RS01925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1560_RS01930	COG0436	Aminotransferase
SynA1560_RS01940	COG1530	ribonuclease E activity
SynA1560_RS01945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynA1560_RS01955	COG0077	Prephenate dehydratase
SynA1560_RS01960	COG2226	methyltransferase
SynA1560_RS01965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynA1560_RS01970	COG0051	transcription antitermination factor activity, RNA binding
SynA1560_RS01975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynA1560_RS01980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynA1560_RS01985	COG0049	tRNA binding
SynA1560_RS01990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynA1560_RS02005	COG0069	glutamate synthase activity
SynA1560_RS02005	COG0067	glutamate synthase
SynA1560_RS02005	COG0070	glutamate synthase
SynA1560_RS02015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1560_RS02035	COG2885	chlorophyll binding
SynA1560_RS02040	COG2885	chlorophyll binding
SynA1560_RS02075	COG0463	Glycosyl transferase, family 2
SynA1560_RS02095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynA1560_RS02105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynA1560_RS02115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynA1560_RS02120	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynA1560_RS02125	COG0101	tRNA pseudouridine synthase activity
SynA1560_RS02130	COG0203	ribosomal protein L17
SynA1560_RS02135	COG0202	RNA polymerase activity
SynA1560_RS02140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynA1560_RS02145	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynA1560_RS02150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynA1560_RS02155	COG0563	adenylate kinase activity
SynA1560_RS02160	COG0201	protein transport
SynA1560_RS02165	COG0200	Binds to the 23S rRNA
SynA1560_RS02170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynA1560_RS02175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynA1560_RS02180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynA1560_RS02185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynA1560_RS02190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynA1560_RS02195	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynA1560_RS02200	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynA1560_RS02205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynA1560_RS02210	COG0255	Belongs to the universal ribosomal protein uL29 family
SynA1560_RS02215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynA1560_RS02220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynA1560_RS02225	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynA1560_RS02230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynA1560_RS02235	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynA1560_RS02240	COG0089	rRNA binding
SynA1560_RS02245	COG0088	Forms part of the polypeptide exit tunnel
SynA1560_RS02250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynA1560_RS02265	COG3854	ATPases associated with a variety of cellular activities
SynA1560_RS02280	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynA1560_RS02300	COG0287	Prephenate dehydrogenase
SynA1560_RS02310	COG3001	Fructosamine kinase
SynA1560_RS02330	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynA1560_RS02335	COG1606	tRNA processing
SynA1560_RS02340	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynA1560_RS02345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynA1560_RS02360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynA1560_RS02365	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynA1560_RS02370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynA1560_RS02385	COG0772	Belongs to the SEDS family
SynA1560_RS02390	COG0489	protein tyrosine kinase activity
SynA1560_RS02395	COG0408	coproporphyrinogen oxidase activity
SynA1560_RS02440	COG0667	Aldo Keto reductase
SynA1560_RS02450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynA1560_RS02455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA1560_RS02460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynA1560_RS02460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynA1560_RS02465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynA1560_RS02625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1560_RS02665	COG1070	Carbohydrate kinase
SynA1560_RS02670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynA1560_RS02680	COG0539	negative regulation of cytoplasmic translation
SynA1560_RS02685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynA1560_RS02720	COG0758	DNA mediated transformation
SynA1560_RS02720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1560_RS02725	COG2890	protein-(glutamine-N5) methyltransferase activity
SynA1560_RS02730	COG0009	L-threonylcarbamoyladenylate synthase
SynA1560_RS02745	COG2197	response regulator
SynA1560_RS02750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynA1560_RS02755	COG2894	cell division
SynA1560_RS02760	COG0850	regulation of cytokinetic process
SynA1560_RS02765	COG1078	dGTPase activity
SynA1560_RS02770	COG0793	Belongs to the peptidase S41A family
SynA1560_RS02775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1560_RS02780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1560_RS02835	COG1570	exodeoxyribonuclease VII activity
SynA1560_RS02845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1560_RS02850	COG1643	Atp-dependent helicase
SynA1560_RS02865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1560_RS02870	COG0488	(ABC) transporter
SynA1560_RS02890	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynA1560_RS02895	COG0569	domain protein
SynA1560_RS02900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynA1560_RS02905	COG3273	potassium ion transport
SynA1560_RS02905	COG0471	metal ion transport
SynA1560_RS02910	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynA1560_RS02915	COG1252	NADH dehydrogenase
SynA1560_RS02920	COG0175	sulfate reduction
SynA1560_RS02925	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynA1560_RS02930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1560_RS02955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynA1560_RS02965	COG0033	Phosphoglucomutase
SynA1560_RS03005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1560_RS03025	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynA1560_RS03030	COG0719	Fe-S assembly protein
SynA1560_RS03035	COG0396	ATPase activity
SynA1560_RS03040	COG0719	Fe-S assembly protein
SynA1560_RS03045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynA1560_RS03055	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynA1560_RS03060	COG0235	Class ii aldolase
SynA1560_RS03070	COG0242	peptide deformylase activity
SynA1560_RS03085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynA1560_RS03095	COG0606	chelatase, subunit chli
SynA1560_RS03100	COG0537	adenosine 5'-monophosphoramidase activity
SynA1560_RS03105	COG4178	(ABC) transporter
SynA1560_RS03125	COG0515	serine threonine protein kinase
SynA1560_RS03140	COG0439	Biotin carboxylase
SynA1560_RS03155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1560_RS03165	COG1196	nuclear chromosome segregation
SynA1560_RS03185	COG0116	Belongs to the methyltransferase superfamily
SynA1560_RS03270	COG0492	ferredoxin-NADP+ reductase activity
SynA1560_RS03275	COG0716	FMN binding
SynA1560_RS03290	COG0659	secondary active sulfate transmembrane transporter activity
SynA1560_RS03300	COG0484	heat shock protein binding
SynA1560_RS03305	COG0113	porphobilinogen synthase activity
SynA1560_RS03315	COG1193	negative regulation of DNA recombination
SynA1560_RS03320	COG3842	ATPase activity
SynA1560_RS03325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynA1560_RS03345	COG0488	(ABC) transporter
SynA1560_RS03355	COG0435	Glutathione S-transferase
SynA1560_RS03360	COG2988	succinylglutamate desuccinylase activity
SynA1560_RS03410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynA1560_RS03420	COG0195	Participates in both transcription termination and antitermination
SynA1560_RS03425	COG0779	Required for maturation of 30S ribosomal subunits
SynA1560_RS03430	COG0641	radical SAM
SynA1560_RS03450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1560_RS03455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynA1560_RS03460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynA1560_RS03465	COG0268	Binds directly to 16S ribosomal RNA
SynA1560_RS03470	COG0084	hydrolase, TatD family'
SynA1560_RS03475	COG0085	RNA polymerase activity
SynA1560_RS03480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1560_RS03485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1560_RS03495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynA1560_RS03530	COG0357	Ribosomal RNA small subunit methyltransferase G
SynA1560_RS03545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynA1560_RS03560	COG4106	trans-aconitate 2-methyltransferase activity
SynA1560_RS03560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynA1560_RS03575	COG0156	8-amino-7-oxononanoate synthase activity
SynA1560_RS03580	COG0385	Bile acid
SynA1560_RS03585	COG4581	dead DEAH box helicase
SynA1560_RS03590	COG0114	fumarate hydratase activity
SynA1560_RS03600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynA1560_RS03615	COG0347	Belongs to the P(II) protein family
SynA1560_RS03625	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynA1560_RS03630	COG1333	cytochrome c biogenesis protein
SynA1560_RS03635	COG4232	protein-disulfide reductase activity
SynA1560_RS03640	COG0772	Belongs to the SEDS family
SynA1560_RS03660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1560_RS03665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1560_RS03675	COG0356	it plays a direct role in the translocation of protons across the membrane
SynA1560_RS03680	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1560_RS03685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1560_RS03690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1560_RS03695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1560_RS03700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynA1560_RS03705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynA1560_RS03715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1560_RS03725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1560_RS03730	COG3012	SEC-C Motif Domain Protein
SynA1560_RS03760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynA1560_RS03760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1560_RS03765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynA1560_RS03770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynA1560_RS03775	COG1253	flavin adenine dinucleotide binding
SynA1560_RS03780	COG0006	proline dipeptidase activity
SynA1560_RS03800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynA1560_RS03805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynA1560_RS03810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynA1560_RS03815	COG0459	protein refolding
SynA1560_RS03820	COG1970	mechanosensitive ion channel activity
SynA1560_RS03830	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynA1560_RS03835	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynA1560_RS03850	COG0443	Heat shock 70 kDa protein
SynA1560_RS03885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynA1560_RS03910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynA1560_RS03915	COG2264	protein methyltransferase activity
SynA1560_RS03930	COG2010	Cytochrome c
SynA1560_RS03935	COG1234	tRNA 3'-trailer cleavage
SynA1560_RS03940	COG2247	cell wall binding repeat
SynA1560_RS03940	COG2385	sporulation resulting in formation of a cellular spore
SynA1560_RS03945	COG0363	glucosamine-6-phosphate deaminase activity
SynA1560_RS03965	COG0217	transcriptional regulatory protein
SynA1560_RS03970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynA1560_RS03975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1560_RS03985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynA1560_RS03990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynA1560_RS04000	COG4251	negative regulation of phosphorylation
SynA1560_RS04005	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynA1560_RS04010	COG5002	protein histidine kinase activity
SynA1560_RS04015	COG0151	Belongs to the GarS family
SynA1560_RS04025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynA1560_RS04035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynA1560_RS04040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynA1560_RS04045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1560_RS04055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1560_RS04075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynA1560_RS04100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynA1560_RS04115	COG0284	orotidine-5'-phosphate decarboxylase activity
SynA1560_RS04125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynA1560_RS04140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynA1560_RS04145	COG2211	Major facilitator Superfamily
SynA1560_RS04165	COG0776	regulation of translation
SynA1560_RS04170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1560_RS04335	COG1231	oxidoreductase activity
SynA1560_RS04385	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynA1560_RS04395	COG1185	polyribonucleotide nucleotidyltransferase activity
SynA1560_RS04400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynA1560_RS04405	COG0750	zinc metalloprotease
SynA1560_RS04410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynA1560_RS04420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1560_RS04430	COG0706	membrane insertase activity
SynA1560_RS04440	COG0594	ribonuclease P activity
SynA1560_RS04445	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynA1560_RS04460	COG0616	signal peptide processing
SynA1560_RS04465	COG0697	spore germination
SynA1560_RS04485	COG1842	Phage shock protein A
SynA1560_RS04495	COG0436	Aminotransferase
SynA1560_RS04500	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynA1560_RS04500	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynA1560_RS04505	COG0739	heme binding
SynA1560_RS04510	COG0745	RESPONSE REGULATOR receiver
SynA1560_RS04515	COG1136	(ABC) transporter
SynA1560_RS04515	COG0577	efflux transmembrane transporter activity
SynA1560_RS04520	COG1007	ATP synthesis coupled electron transport
SynA1560_RS04525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynA1560_RS04540	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynA1560_RS04575	COG1845	cytochrome c oxidase, subunit III
SynA1560_RS04580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynA1560_RS04590	COG1612	heme a metabolic process
SynA1560_RS04595	COG0109	protoheme IX farnesyltransferase activity
SynA1560_RS04615	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynA1560_RS04625	COG0459	protein refolding
SynA1560_RS04635	COG1028	Short-chain dehydrogenase reductase Sdr
SynA1560_RS04640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynA1560_RS04650	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynA1560_RS04655	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1560_RS04660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1560_RS04665	COG0248	Ppx GppA phosphatase
SynA1560_RS04695	COG3258	Cytochrome c
SynA1560_RS04700	COG0723	plastoquinol--plastocyanin reductase activity
SynA1560_RS04710	COG0805	protein transport
SynA1560_RS04715	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynA1560_RS04720	COG0194	GDP metabolic process
SynA1560_RS04735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynA1560_RS04740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1560_RS04750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynA1560_RS04765	COG3263	regulation of cellular component size
SynA1560_RS04770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1560_RS04795	COG0335	large ribosomal subunit rRNA binding
SynA1560_RS04805	COG0024	Methionine aminopeptidase
SynA1560_RS04810	COG0300	oxidoreductase activity
SynA1560_RS04810	COG3000	fatty acid hydroxylase
SynA1560_RS04820	COG0857	belongs to the CobB CobQ family
SynA1560_RS04835	COG0330	HflC and HflK could
SynA1560_RS04845	COG1666	GTP binding
SynA1560_RS04855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynA1560_RS04860	COG0277	FAD linked oxidase domain protein
SynA1560_RS04885	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynA1560_RS04905	COG0523	cobalamin synthesis protein
SynA1560_RS04910	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynA1560_RS04920	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynA1560_RS04925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1560_RS04945	COG0181	hydroxymethylbilane synthase activity
SynA1560_RS05000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1560_RS05005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynA1560_RS05015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynA1560_RS05030	COG0629	single-stranded DNA binding
SynA1560_RS05035	COG2099	Precorrin-6x reductase
SynA1560_RS05045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynA1560_RS05050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynA1560_RS05060	COG0442	prolyl-tRNA aminoacylation
SynA1560_RS05075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1560_RS05095	COG0681	Belongs to the peptidase S26 family
SynA1560_RS05100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SynA1560_RS05120	COG0768	penicillin binding
SynA1560_RS05125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynA1560_RS05135	COG0415	Belongs to the DNA photolyase family
SynA1560_RS05145	COG0233	cytoplasmic translational termination
SynA1560_RS05150	COG0528	UMP kinase activity
SynA1560_RS05165	COG2226	methyltransferase
SynA1560_RS05175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1560_RS05180	COG0028	Belongs to the TPP enzyme family
SynA1560_RS05195	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynA1560_RS05200	COG1496	oxidoreductase activity
SynA1560_RS05210	COG0539	negative regulation of cytoplasmic translation
SynA1560_RS05220	COG3396	Phenylacetate-CoA oxygenase
SynA1560_RS05225	COG5322	oxidoreductase activity
SynA1560_RS05230	COG0825	malonyl-CoA metabolic process
SynA1560_RS05240	COG0302	gtp cyclohydrolase
SynA1560_RS05245	COG0135	phosphoribosylanthranilate isomerase activity
SynA1560_RS05250	COG1994	Peptidase M50
SynA1560_RS05250	COG0517	IMP dehydrogenase activity
SynA1560_RS05255	COG0095	Lipoate-protein ligase
SynA1560_RS05260	COG0730	response to heat
SynA1560_RS05300	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynA1560_RS05305	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1560_RS05310	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1560_RS05320	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1560_RS05325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1560_RS05330	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1560_RS05335	COG1850	ribulose-bisphosphate carboxylase activity
SynA1560_RS05340	COG4451	ribulose bisphosphate carboxylase, small
SynA1560_RS05365	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1560_RS05370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1560_RS05375	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1560_RS05400	COG0251	oxidation-reduction process
SynA1560_RS05410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynA1560_RS05415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynA1560_RS05420	COG1132	(ABC) transporter
SynA1560_RS05425	COG0596	Alpha beta hydrolase
SynA1560_RS05430	COG0456	acetyltransferase
SynA1560_RS05445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1560_RS05450	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynA1560_RS05470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1560_RS05485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynA1560_RS05505	COG0530	calcium, potassium:sodium antiporter activity
SynA1560_RS05510	COG0659	secondary active sulfate transmembrane transporter activity
SynA1560_RS05515	COG0418	dihydroorotase activity
SynA1560_RS05530	COG0251	oxidation-reduction process
SynA1560_RS05560	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynA1560_RS05560	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynA1560_RS05585	COG0159	tryptophan synthase activity
SynA1560_RS05600	COG2010	Cytochrome c
SynA1560_RS05625	COG3339	Conserved Protein
SynA1560_RS05630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1560_RS05650	COG1376	ErfK ybiS ycfS ynhG family protein
SynA1560_RS05660	COG0140	phosphoribosyl-ATP diphosphatase activity
SynA1560_RS05660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynA1560_RS05670	COG0823	Involved in the tonB-independent uptake of proteins
SynA1560_RS05670	COG1506	peptidase
SynA1560_RS05670	COG4946	Tricorn protease homolog
SynA1560_RS05680	COG0542	response to heat
SynA1560_RS05745	COG3794	PFAM blue (type 1) copper domain protein
SynA1560_RS05755	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynA1560_RS05760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynA1560_RS05800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynA1560_RS05805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SynA1560_RS05835	COG0339	signal peptide processing
SynA1560_RS05840	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1560_RS05845	COG0083	homoserine kinase activity
SynA1560_RS05850	COG0837	glucose binding
SynA1560_RS05860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynA1560_RS05880	COG0180	Tryptophanyl-tRNA synthetase
SynA1560_RS05905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1560_RS05915	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynA1560_RS05940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1560_RS05945	COG0351	phosphomethylpyrimidine kinase
SynA1560_RS05950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynA1560_RS06015	COG3781	membrane
SynA1560_RS06250	COG0590	tRNA wobble adenosine to inosine editing
SynA1560_RS06305	COG0484	heat shock protein binding
SynA1560_RS06390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1560_RS06410	COG0515	serine threonine protein kinase
SynA1560_RS06420	COG2072	flavoprotein involved in K transport
SynA1560_RS06445	COG2144	transferase activity, transferring acyl groups
SynA1560_RS06500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SynA1560_RS06540	COG2197	response regulator
SynA1560_RS06565	COG2124	cytochrome p450
SynA1560_RS06580	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynA1560_RS06605	COG0793	Belongs to the peptidase S41A family
SynA1560_RS06610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynA1560_RS06615	COG1573	uracil-dna glycosylase
SynA1560_RS06625	COG0436	Aminotransferase
SynA1560_RS06630	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynA1560_RS06635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA1560_RS06635	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynA1560_RS06640	COG3639	organic phosphonate transmembrane transporter activity
SynA1560_RS06675	COG0668	transmembrane transport
SynA1560_RS06680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1560_RS06735	COG1126	abc transporter atp-binding protein
SynA1560_RS06740	COG0765	amino acid transport
SynA1560_RS06750	COG4597	amino acid ABC transporter
SynA1560_RS06755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynA1560_RS06765	COG0659	secondary active sulfate transmembrane transporter activity
SynA1560_RS06805	COG0799	negative regulation of ribosome biogenesis
SynA1560_RS06815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynA1560_RS06825	COG1115	amino acid carrier protein
SynA1560_RS06835	COG1132	(ABC) transporter
SynA1560_RS06845	COG0149	triose-phosphate isomerase activity
SynA1560_RS06850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynA1560_RS06860	COG1429	ligase activity, forming nitrogen-metal bonds
SynA1560_RS06865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynA1560_RS06875	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1560_RS06880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynA1560_RS06890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA1560_RS06925	COG2205	protein histidine kinase activity
SynA1560_RS06955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynA1560_RS06960	COG1494	fructose-1,6-bisphosphatase
SynA1560_RS06965	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynA1560_RS06970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1560_RS06975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynA1560_RS06980	COG0363	glucosamine-6-phosphate deaminase activity
SynA1560_RS06995	COG0129	dihydroxy-acid dehydratase activity
SynA1560_RS07005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynA1560_RS07010	COG1357	PFAM Pentapeptide repeats (8 copies)
SynA1560_RS07050	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1560_RS07055	COG0047	phosphoribosylformylglycinamidine synthase activity
SynA1560_RS07060	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1560_RS07085	COG0191	fructose-bisphosphate aldolase activity
SynA1560_RS07090	COG3588	fructose-bisphosphate aldolase
SynA1560_RS07100	COG0673	inositol 2-dehydrogenase activity
SynA1560_RS07110	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynA1560_RS07115	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynA1560_RS07125	COG3954	Phosphoribulokinase
SynA1560_RS07130	COG0473	3-isopropylmalate dehydrogenase activity
SynA1560_RS07135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1560_RS07140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynA1560_RS07155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynA1560_RS07170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA1560_RS07175	COG2197	response regulator
SynA1560_RS07185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynA1560_RS07200	COG0516	GMP reductase activity
SynA1560_RS07200	COG0517	IMP dehydrogenase activity
SynA1560_RS07230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1560_RS07240	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynA1560_RS07335	COG1201	RNA secondary structure unwinding
SynA1560_RS07355	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynA1560_RS07370	COG1793	dna ligase
SynA1560_RS07380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SynA1560_RS07380	COG1793	dna ligase
SynA1560_RS07415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynA1560_RS07420	COG1175	transmembrane transport
SynA1560_RS07425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynA1560_RS07485	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1560_RS07510	COG0740	serine-type endopeptidase activity
SynA1560_RS07515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1560_RS07520	COG0577	efflux transmembrane transporter activity
SynA1560_RS07520	COG1136	(ABC) transporter
SynA1560_RS07525	COG0469	pyruvate kinase activity
SynA1560_RS07545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynA1560_RS07550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynA1560_RS07575	COG3842	ATPase activity
SynA1560_RS07590	COG1653	transport
SynA1560_RS07595	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynA1560_RS07600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1560_RS07605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynA1560_RS07610	COG0326	Molecular chaperone. Has ATPase activity
SynA1560_RS07620	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynA1560_RS07625	COG0483	inositol monophosphate 1-phosphatase activity
SynA1560_RS07640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynA1560_RS07645	COG0581	inorganic phosphate transmembrane transporter activity
SynA1560_RS07650	COG0573	inorganic phosphate transmembrane transporter activity
SynA1560_RS07655	COG0443	Heat shock 70 kDa protein
SynA1560_RS07660	COG0484	heat shock protein binding
SynA1560_RS07670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynA1560_RS07675	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynA1560_RS07680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1560_RS07685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1560_RS07685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1560_RS07690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynA1560_RS07695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynA1560_RS07720	COG0166	Belongs to the GPI family
SynA1560_RS07725	COG0495	leucyl-tRNA aminoacylation
SynA1560_RS07735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynA1560_RS07740	COG1104	cysteine desulfurase activity
SynA1560_RS07765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynA1560_RS07770	COG0322	excinuclease ABC activity
SynA1560_RS07780	COG3046	protein related to deoxyribodipyrimidine photolyase
SynA1560_RS07785	COG1981	membrane
SynA1560_RS07805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynA1560_RS07810	COG1410	methionine synthase
SynA1560_RS07810	COG0646	methionine synthase
SynA1560_RS07835	COG2385	sporulation resulting in formation of a cellular spore
SynA1560_RS07845	COG1191	sigma factor activity
SynA1560_RS07870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynA1560_RS07875	COG0072	phenylalanine-tRNA ligase activity
SynA1560_RS07875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA1560_RS07880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynA1560_RS07885	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynA1560_RS07890	COG0557	exoribonuclease II activity
SynA1560_RS07900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA1560_RS07930	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SynA1560_RS07935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynA1560_RS07955	COG0450	alkyl hydroperoxide reductase
SynA1560_RS07960	COG1615	UPF0182 protein
SynA1560_RS07965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1560_RS07970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynA1560_RS07985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynA1560_RS07990	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynA1560_RS07990	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynA1560_RS08010	COG2119	membrane
SynA1560_RS08020	COG0557	exoribonuclease II activity
SynA1560_RS08025	COG0163	prenyltransferase activity
SynA1560_RS08040	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynA1560_RS08045	COG0312	modulator of DNA gyrase
SynA1560_RS08055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynA1560_RS08060	COG0513	Belongs to the DEAD box helicase family
SynA1560_RS08080	COG0861	Integral membrane protein TerC family
SynA1560_RS08185	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynA1560_RS08210	COG0745	RESPONSE REGULATOR receiver
SynA1560_RS08220	COG0596	Alpha beta hydrolase
SynA1560_RS08225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynA1560_RS08230	COG0271	Belongs to the BolA IbaG family
SynA1560_RS08245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynA1560_RS08280	COG0735	belongs to the Fur family
SynA1560_RS08290	COG1799	cell septum assembly
SynA1560_RS08315	COG0420	3'-5' exonuclease activity
SynA1560_RS08355	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynA1560_RS08395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynA1560_RS08420	COG1217	gtp-binding protein TYPA
SynA1560_RS08425	COG0826	peptidase U32
SynA1560_RS08435	COG0644	oxidoreductase
SynA1560_RS08440	COG0751	glycine-tRNA ligase activity
SynA1560_RS08445	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1560_RS08450	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynA1560_RS08455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynA1560_RS08465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynA1560_RS08470	COG0052	Belongs to the universal ribosomal protein uS2 family
SynA1560_RS08475	COG1216	Glycosyl transferase, family 2
SynA1560_RS08505	COG0612	Peptidase, M16
SynA1560_RS08525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynA1560_RS08530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynA1560_RS08550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynA1560_RS08560	COG0174	glutamine synthetase
SynA1560_RS08570	COG2226	methyltransferase
SynA1560_RS08590	COG0515	serine threonine protein kinase
SynA1560_RS08595	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynA1560_RS08605	COG0628	permease
SynA1560_RS08630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1560_RS08635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1560_RS08640	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA1560_RS08640	COG0022	dehydrogenase e1 component
SynA1560_RS08650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynA1560_RS08655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynA1560_RS08660	COG0572	uridine kinase
SynA1560_RS08680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynA1560_RS08705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1560_RS08740	COG0358	DNA primase activity
SynA1560_RS08760	COG0632	four-way junction helicase activity
SynA1560_RS08765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynA1560_RS08775	COG0587	DNA-directed DNA polymerase activity
SynA1560_RS08780	COG0154	amidase activity
SynA1560_RS08790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1560_RS08795	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynA1560_RS08805	COG0505	Belongs to the CarA family
SynA1560_RS08810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1560_RS08815	COG1132	(ABC) transporter
SynA1560_RS08825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1560_RS08845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1560_RS08860	COG2176	DNA-directed DNA polymerase activity
SynA1560_RS08865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1560_RS08880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynA1560_RS08890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynA1560_RS08895	COG0142	geranyltranstransferase activity
SynA1560_RS08900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynA1560_RS08915	COG2045	Belongs to the ComB family
SynA1560_RS08920	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynA1560_RS08925	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA1560_RS08930	COG3128	pkhd-type hydroxylase
SynA1560_RS08940	COG3659	wide pore channel activity
SynA1560_RS08945	COG3659	wide pore channel activity
SynA1560_RS08950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynA1560_RS08960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1560_RS08965	COG4178	(ABC) transporter
SynA1560_RS08970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynA1560_RS08980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynA1560_RS08990	COG0297	glycogen (starch) synthase activity
SynA1560_RS08995	COG1376	ErfK ybiS ycfS ynhG family protein
SynA1560_RS09000	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynA1560_RS09005	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynA1560_RS09010	COG0681	Belongs to the peptidase S26 family
SynA1560_RS09025	COG0583	DNA-binding transcription factor activity
SynA1560_RS09030	COG3239	Fatty acid desaturase
SynA1560_RS09045	COG1231	oxidoreductase activity
SynA1560_RS09055	COG2132	Multicopper oxidase
SynA1560_RS09065	COG3961	Belongs to the TPP enzyme family
SynA1560_RS09190	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA1560_RS09195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1560_RS09200	COG1121	(ABC) transporter
SynA1560_RS09215	COG0701	Predicted permease
SynA1560_RS09220	COG2010	Cytochrome c
SynA1560_RS09235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1560_RS09240	COG1121	(ABC) transporter
SynA1560_RS09300	COG0583	DNA-binding transcription factor activity
SynA1560_RS09320	COG2032	superoxide dismutase activity
SynA1560_RS09395	COG0300	oxidoreductase activity
SynA1560_RS09440	COG2720	vancomycin resistance protein
SynA1560_RS09455	COG1191	sigma factor activity
SynA1560_RS09460	COG1836	PFAM Integral membrane protein DUF92
SynA1560_RS09490	COG1122	ATPase activity
SynA1560_RS09495	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynA1560_RS09515	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynA1560_RS09520	COG4106	trans-aconitate 2-methyltransferase activity
SynA1560_RS09525	COG0668	transmembrane transport
SynA1560_RS09530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynA1560_RS09625	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SynA1560_RS09710	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynA1560_RS09715	COG1074	ATP-dependent DNA helicase activity
SynA1560_RS09720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA1560_RS09730	COG0513	Belongs to the DEAD box helicase family
SynA1560_RS09740	COG0724	RNA recognition motif
SynA1560_RS09745	COG1132	(ABC) transporter
SynA1560_RS09750	COG0589	response to stress
SynA1560_RS09750	COG0475	glutathione-regulated potassium exporter activity
SynA1560_RS09790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynA1560_RS09795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1560_RS09810	COG1054	Belongs to the UPF0176 family
SynA1560_RS09815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynA1560_RS09820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynA1560_RS09825	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynA1560_RS09830	COG0019	diaminopimelate decarboxylase activity
SynA1560_RS09840	COG0542	response to heat
SynA1560_RS09845	COG0371	Dehydrogenase
SynA1560_RS09850	COG2267	carboxylic ester hydrolase activity
SynA1560_RS09860	COG0575	Belongs to the CDS family
SynA1560_RS09865	COG1982	Orn Lys Arg decarboxylase major
SynA1560_RS09870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1560_RS09880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1560_RS09885	COG0745	RESPONSE REGULATOR receiver
SynA1560_RS09890	COG5002	protein histidine kinase activity
SynA1560_RS09895	COG1187	pseudouridine synthase activity
SynA1560_RS09905	COG1640	4-alpha-glucanotransferase
SynA1560_RS09910	COG0702	epimerase
SynA1560_RS09925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynA1560_RS09945	COG0308	aminopeptidase N
SynA1560_RS09960	COG2205	protein histidine kinase activity
SynA1560_RS09975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SynA1560_RS09980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynA1560_RS09985	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynA1560_RS09985	COG3409	Peptidoglycan-binding domain 1 protein
SynA1560_RS09990	COG1797	cobyrinic acid a,c-diamide synthase activity
SynA1560_RS09995	COG1254	Belongs to the acylphosphatase family
SynA1560_RS10015	COG0142	geranyltranstransferase activity
SynA1560_RS10020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynA1560_RS10025	COG1480	7TM receptor with intracellular HD hydrolase
SynA1560_RS10030	COG0564	pseudouridine synthase activity
SynA1560_RS10050	COG0011	TIGRFAM Protein of
SynA1560_RS10070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1560_RS10090	COG0395	ABC-type sugar transport system, permease component
SynA1560_RS10095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynA1560_RS10100	COG1543	Belongs to the glycosyl hydrolase 57 family
SynA1560_RS10115	COG0644	oxidoreductase
SynA1560_RS10120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1560_RS10130	COG0516	GMP reductase activity
SynA1560_RS10135	COG3118	belongs to the thioredoxin family
SynA1560_RS10140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynA1560_RS10150	COG2010	Cytochrome c
SynA1560_RS10170	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1560_RS10175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynA1560_RS10190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynA1560_RS10200	COG2166	iron-sulfur cluster assembly
SynA1560_RS10205	COG0460	homoserine dehydrogenase
SynA1560_RS10215	COG0747	negative chemotaxis
SynA1560_RS10220	COG0601	transmembrane transport
SynA1560_RS10255	COG0012	GTP binding
SynA1560_RS10260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynA1560_RS10265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1560_RS10265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1560_RS10270	COG0215	cysteine-tRNA ligase activity
SynA1560_RS10285	COG0733	neurotransmitter:sodium symporter activity
SynA1560_RS10290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynA1560_RS10295	COG3411	Ferredoxin
SynA1560_RS10335	COG0492	ferredoxin-NADP+ reductase activity
SynA1560_RS10340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynA1560_RS10355	COG2226	methyltransferase
SynA1560_RS10365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1560_RS10385	COG0440	acetolactate synthase activity
SynA1560_RS10390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1560_RS10415	COG0424	maF-like protein
SynA1560_RS10435	COG2274	protein secretion by the type I secretion system
SynA1560_RS10450	COG1492	cobalamin metabolic process
SynA1560_RS10475	COG0432	Pfam Uncharacterised protein family UPF0047
SynA1560_RS10515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SynA1560_RS10545	COG2770	Histidine kinase
SynA1560_RS10545	COG2208	phosphoserine phosphatase activity
SynA1560_RS10615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1560_RS10630	COG1647	Serine aminopeptidase, S33
SynA1560_RS10660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynA1560_RS10665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1560_RS10675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1560_RS10675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1560_RS10715	COG3119	arylsulfatase activity
SynA1560_RS10720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynA1560_RS10755	COG0745	RESPONSE REGULATOR receiver
SynA1560_RS10760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1560_RS10775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynA1560_RS10780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynA1560_RS10790	COG0196	riboflavin kinase activity
SynA1560_RS10795	COG0352	thiamine-phosphate diphosphorylase activity
SynA1560_RS10820	COG1691	(AIR) carboxylase
SynA1560_RS10840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynA1560_RS10855	COG0670	Belongs to the BI1 family
SynA1560_RS10860	COG1702	phosphate starvation-inducible protein PhoH
SynA1560_RS10865	COG0228	four-way junction DNA binding
SynA1560_RS10870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynA1560_RS10880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynA1560_RS10885	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynA1560_RS10890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1560_RS10895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynA1560_RS10895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynA1560_RS10900	COG0482	sulfurtransferase activity
SynA1560_RS10905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynA1560_RS10935	COG1007	ATP synthesis coupled electron transport
SynA1560_RS10965	COG0134	indole-3-glycerol-phosphate synthase activity
SynA1560_RS10970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1560_RS10975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1560_RS10990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynA1560_RS11010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA1560_RS11015	COG0285	dihydrofolate synthase activity
SynA1560_RS11050	COG4948	Mandelate Racemase Muconate Lactonizing
SynA1560_RS11055	COG2066	Belongs to the glutaminase family
SynA1560_RS11055	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SynA1560_RS11060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1560_RS11065	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynA1560_RS11080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynA1560_RS11090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynA1560_RS11095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynA1560_RS11100	COG4956	integral membrane protein (PIN domain superfamily)
SynA1560_RS11105	COG0740	serine-type endopeptidase activity
SynA1560_RS11110	COG0740	serine-type endopeptidase activity
SynA1560_RS11115	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynA1560_RS11125	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynA1560_RS11155	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynA1560_RS11180	COG0752	glycyl-tRNA synthetase alpha subunit
SynA1560_RS11190	COG2226	methyltransferase
SynA1560_RS11200	COG0107	imidazoleglycerol-phosphate synthase activity
SynA1560_RS11210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1560_RS11215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynA1560_RS11220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynA1560_RS11220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1560_RS11225	COG3695	enzyme binding
SynA1560_RS11235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1560_RS11245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SynA1560_RS11250	COG4999	Histidine kinase
SynA1560_RS11250	COG3850	Histidine kinase
SynA1560_RS11250	COG3437	response regulator, receiver
SynA1560_RS11250	COG2205	protein histidine kinase activity
SynA1560_RS11260	COG2205	protein histidine kinase activity
SynA1560_RS11285	COG0745	RESPONSE REGULATOR receiver
SynA1560_RS11325	COG0481	GTPase activity
SynA1560_RS11340	COG0579	oxidoreductase
SynA1560_RS11345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynA1560_RS11355	COG1104	cysteine desulfurase activity
SynA1560_RS11360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynA1560_RS11395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1560_RS11405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynA1560_RS11410	COG0531	amino acid
SynA1560_RS11415	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA1560_RS11425	COG1022	Amp-dependent synthetase and ligase
SynA1560_RS11430	COG0321	lipoyl(octanoyl) transferase activity
SynA1560_RS11435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynA1560_RS11440	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynA1560_RS11445	COG1381	Involved in DNA repair and RecF pathway recombination
SynA1560_RS11455	COG0438	transferase activity, transferring glycosyl groups
SynA1560_RS11460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynA1560_RS11465	COG1799	cell septum assembly
SynA1560_RS11480	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynA1560_RS11485	COG1160	GTP binding
SynA1560_RS11490	COG1376	ErfK ybiS ycfS ynhG family protein
SynA1560_RS11505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1560_RS11520	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynA1560_RS11540	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynA1560_RS11560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynA1560_RS11565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynA1560_RS11575	COG1012	belongs to the aldehyde dehydrogenase family
SynA1560_RS11580	COG3942	CHAP domain
SynA1560_RS11580	COG1388	LysM domain
SynA1560_RS11600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynA1560_RS11605	COG0235	Class ii aldolase
SynA1560_RS11610	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynA1560_RS11640	COG0483	inositol monophosphate 1-phosphatase activity
SynA1560_RS11655	COG1968	undecaprenyl-diphosphatase activity
SynA1560_RS11665	COG1555	photosystem II stabilization
SynA1560_RS11670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynA1560_RS11675	COG4243	Vitamin k epoxide reductase
SynA1560_RS11680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1560_RS11695	COG1032	radical SAM domain protein
SynA1560_RS11720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynA1560_RS11745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynA1560_RS11750	COG1472	Belongs to the glycosyl hydrolase 3 family
SynA1560_RS11755	COG0457	Tetratricopeptide repeat
SynA1560_RS11755	COG0463	Glycosyl transferase, family 2
SynA1560_RS11760	COG1587	Uroporphyrinogen-III synthase
SynA1560_RS11775	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1560_RS11780	COG0316	Belongs to the HesB IscA family
SynA1560_RS11800	COG1090	epimerase
SynA1560_RS11805	COG3263	regulation of cellular component size
SynA1560_RS11820	COG0484	heat shock protein binding
SynA1560_RS11825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1560_RS11830	COG3659	wide pore channel activity
SynA1560_RS11840	COG1216	Glycosyl transferase, family 2
SynA1560_RS11870	COG1122	ATPase activity
SynA1560_RS11880	COG0745	RESPONSE REGULATOR receiver
SynA1560_RS11890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynA1560_RS11895	COG2217	Heavy metal translocating P-type atpase
SynA1560_RS11900	COG3063	Type IV pilus biogenesis stability protein PilW
SynA1560_RS11905	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynA1560_RS11915	COG0416	fatty acid biosynthetic process
SynA1560_RS11920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynA1560_RS11925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynA1560_RS11940	COG1214	PFAM Peptidase M22, glycoprotease
SynA1560_RS11950	COG0617	tRNA 3'-terminal CCA addition
SynA1560_RS12010	COG2894	cell division
SynA1560_RS12020	COG1562	ergosterol biosynthetic process
SynA1560_RS12035	COG2205	protein histidine kinase activity
SynA1560_RS12035	COG2198	Histidine kinase
SynA1560_RS12035	COG0784	Response regulator, receiver
SynA1560_RS12040	COG0493	'glutamate synthase
SynA1560_RS12040	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1560_RS12055	COG0583	DNA-binding transcription factor activity
SynA1560_RS12065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1560_RS12070	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1560_RS12085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynA1560_RS12095	COG2197	response regulator
SynA1560_RS12105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1560_RS12110	COG0713	ATP synthesis coupled electron transport
SynA1560_RS12115	COG0839	Belongs to the complex I subunit 6 family
SynA1560_RS12120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1560_RS12125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynA1560_RS12130	COG0372	Belongs to the citrate synthase family
SynA1560_RS12135	COG2062	phosphohistidine phosphatase, SixA
SynA1560_RS12150	COG1420	regulation of RNA biosynthetic process
SynA1560_RS12155	COG0133	tryptophan synthase activity
SynA1560_RS12160	COG2226	methyltransferase
SynA1560_RS12165	COG0023	Translation Initiation Factor
SynA1560_RS12170	COG0529	Catalyzes the synthesis of activated sulfate
SynA1560_RS12175	COG0628	permease
SynA1560_RS12185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynA1560_RS12195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1560_RS12200	COG0564	pseudouridine synthase activity
SynA1560_RS12205	COG0745	RESPONSE REGULATOR receiver
SynA1560_RS12225	COG0275	rRNA processing
SynA1560_RS12230	COG0649	NAD binding
SynA1560_RS12240	COG0824	Thioesterase
SynA1560_RS12265	COG1575	Belongs to the MenA family. Type 1 subfamily
SynA1560_RS12280	COG0189	ligase activity
SynA1560_RS12285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA1560_RS12300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynA1560_RS12305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynA1560_RS12310	COG0512	Glutamine amidotransferase of anthranilate synthase
SynA1560_RS12365	COG0252	asparaginase activity
SynA1560_RS12375	COG0018	arginyl-trna synthetase
SynA1560_RS12395	COG0157	Belongs to the NadC ModD family
SynA1560_RS12405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynA1560_RS12415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynA1560_RS12420	COG4172	Belongs to the ABC transporter superfamily
SynA1560_RS12430	COG0564	pseudouridine synthase activity
SynA1560_RS12440	COG0589	response to stress
SynA1560_RS12445	COG0126	phosphoglycerate kinase activity
SynA1560_RS12465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynA1560_RS12470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA1560_RS12500	COG0167	dihydroorotate dehydrogenase activity
SynA1560_RS12505	COG0328	RNA-DNA hybrid ribonuclease activity
SynA1560_RS12515	COG0222	ribosome binding
SynA1560_RS12520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynA1560_RS12525	COG0081	regulation of translation
SynA1560_RS12530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynA1560_RS12535	COG0250	Participates in transcription elongation, termination and antitermination
SynA1560_RS12540	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynA1560_RS12545	COG0542	response to heat
SynA1560_RS12550	COG0346	lactoylglutathione lyase activity
SynA1560_RS12555	COG0148	phosphopyruvate hydratase activity
SynA1560_RS12560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1560_RS12575	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynA1560_RS12580	COG0237	dephospho-CoA kinase activity
SynA1560_RS12590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1560_RS12600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynA1560_RS12600	COG2022	thiamine diphosphate biosynthetic process
SynA1560_RS12605	COG0105	UTP biosynthetic process
SynA1560_RS12610	COG1166	arginine decarboxylase activity
SynA1560_RS12675	COG2274	protein secretion by the type I secretion system
SynA1560_RS12700	COG0668	transmembrane transport
SynA1560_RS12720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynA1560_RS12730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynA1560_RS12755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1560_RS12755	COG0426	domain, Protein
SynA1560_RS12760	COG0426	domain, Protein
SynA1560_RS12760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1560_RS12765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1560_RS12765	COG1773	rubredoxin
SynA1560_RS12775	COG1741	Belongs to the pirin family
SynA1560_RS12795	COG0509	glycine decarboxylation via glycine cleavage system
SynA1560_RS12800	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynA1560_RS12820	COG0359	binds to the 23S rRNA
SynA1560_RS12825	COG1372	Participates in initiation and elongation during chromosome replication
SynA1560_RS12825	COG0305	Participates in initiation and elongation during chromosome replication
SynA1560_RS12825	COG1372	Participates in initiation and elongation during chromosome replication
SynA1560_RS12825	COG0305	Participates in initiation and elongation during chromosome replication
SynA1560_RS12855	COG0445	tRNA wobble uridine modification
SynA1560_RS12895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1560_RS12910	COG0398	Pfam SNARE associated Golgi protein
SynA1560_RS12925	COG0668	transmembrane transport
SynA1560_RS12945	COG0525	valine-tRNA ligase activity
SynA1560_RS12955	COG3264	Mechanosensitive ion channel
SynA1560_RS12955	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynA1560_RS12975	COG1028	Short-chain dehydrogenase reductase Sdr
SynA1560_RS13050	COG3956	TIGRFAM MazG family protein
SynA1560_RS13055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynA1560_RS13065	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynA1560_RS13070	COG0010	Belongs to the arginase family
SynA1560_RS13085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynA1560_RS13090	COG2770	Histidine kinase
SynA1560_RS13090	COG2208	phosphoserine phosphatase activity
SynA1560_RS13130	COG2770	Histidine kinase
SynA1560_RS13130	COG2208	phosphoserine phosphatase activity
SynA1560_RS13140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynA1560_RS13145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1560_RS13150	COG0783	Belongs to the Dps family
SynA1560_RS13155	COG0504	CTP synthase activity
SynA1560_RS13160	COG0602	queuosine metabolic process
SynA1560_RS13165	COG4942	peptidase
SynA1560_RS13170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SynA1560_RS13185	COG4574	serine-type endopeptidase inhibitor activity
SynA1560_RS13190	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynA1560_RS13210	COG3769	mannosylglycerate metabolic process
SynA1560_RS13215	COG0366	Alpha amylase catalytic
SynA1560_RS13255	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynA1560_RS13260	COG0830	nickel cation binding
SynA1560_RS13265	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynA1560_RS13270	COG0829	nickel cation binding
SynA1560_RS13275	COG0831	urea catabolic process
SynA1560_RS13280	COG0832	Belongs to the urease beta subunit family
SynA1560_RS13285	COG0804	urea catabolic process
SynA1560_RS13290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynA1560_RS13315	COG0367	asparagine synthase
SynA1560_RS13320	COG0540	Belongs to the ATCase OTCase family
SynA1560_RS13335	COG2308	Evidence 4 Homologs of previously reported genes of
SynA1560_RS13355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynA1560_RS13365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynA1560_RS13370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynA1560_RS13385	COG0243	molybdopterin cofactor binding
SynA1560_RS13400	COG0315	cyclic pyranopterin monophosphate synthase activity
SynA1560_RS13405	COG0303	'Molybdopterin
SynA1560_RS13420	COG0314	molybdopterin synthase activity
SynA1560_RS13430	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynA1560_RS13435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynA1560_RS13450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1560_RS13455	COG2116	formate transmembrane transporter activity
SynA1560_RS13465	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynA1560_RS13475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1560_RS13490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynA1560_RS13495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1560_RS13500	COG0170	dolichyl monophosphate biosynthetic process
SynA1560_RS13510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynA1560_RS13515	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynA1560_RS13535	COG0788	formyltetrahydrofolate deformylase activity
SynA1560_RS13555	COG0443	Heat shock 70 kDa protein
SynA1560_RS13560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynA1560_RS13570	COG0360	Binds together with S18 to 16S ribosomal RNA
SynA1560_RS13580	COG0137	argininosuccinate synthase activity
SynA1560_RS13595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1560_RS13615	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynA1560_RS13620	COG0438	transferase activity, transferring glycosyl groups
SynA1560_RS13630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynA1560_RS13635	COG0497	DNA recombination
SynA1560_RS13640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1560_RS13650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine