locus-tag	class	description
SynA1840_RS00005	COG0592	DNA-directed DNA polymerase activity
SynA1840_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1840_RS00020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynA1840_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1840_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynA1840_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1840_RS00055	COG0552	protein localization to endoplasmic reticulum
SynA1840_RS00060	COG2208	phosphoserine phosphatase activity
SynA1840_RS00065	COG0165	Argininosuccinate lyase
SynA1840_RS00070	COG0724	RNA recognition motif
SynA1840_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1840_RS00080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1840_RS00085	COG2081	HI0933 family
SynA1840_RS00090	COG1459	type II secretion system
SynA1840_RS00105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynA1840_RS00110	COG0484	heat shock protein binding
SynA1840_RS00120	COG1162	GTPase activity
SynA1840_RS00125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynA1840_RS00130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynA1840_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynA1840_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1840_RS00145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynA1840_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1840_RS00155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynA1840_RS00160	COG0511	ligase activity, forming carbon-carbon bonds
SynA1840_RS00165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynA1840_RS00230	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynA1840_RS00235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynA1840_RS00235	COG0519	Catalyzes the synthesis of GMP from XMP
SynA1840_RS00250	COG0768	penicillin binding
SynA1840_RS00255	COG0438	transferase activity, transferring glycosyl groups
SynA1840_RS00260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1840_RS00270	COG2022	thiamine diphosphate biosynthetic process
SynA1840_RS00285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynA1840_RS00290	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynA1840_RS00295	COG2385	sporulation resulting in formation of a cellular spore
SynA1840_RS00300	COG1215	transferase activity, transferring glycosyl groups
SynA1840_RS00305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynA1840_RS00315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynA1840_RS00320	COG0740	serine-type endopeptidase activity
SynA1840_RS00325	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynA1840_RS00330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynA1840_RS00335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynA1840_RS00340	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynA1840_RS00360	COG2082	Precorrin-8x methylmutase
SynA1840_RS00365	COG0037	tRNA processing
SynA1840_RS00375	COG0556	nucleotide-excision repair
SynA1840_RS00380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynA1840_RS00400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynA1840_RS00425	COG0653	protein targeting
SynA1840_RS00445	COG1045	serine acetyltransferase
SynA1840_RS00450	COG1725	Transcriptional regulator
SynA1840_RS00455	COG0412	Dienelactone hydrolase
SynA1840_RS00460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynA1840_RS00465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynA1840_RS00470	COG1372	Participates in initiation and elongation during chromosome replication
SynA1840_RS00470	COG0187	DNA topoisomerase II activity
SynA1840_RS00480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1840_RS00485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA1840_RS00490	COG0386	Belongs to the glutathione peroxidase family
SynA1840_RS00500	COG2239	Acts as a magnesium transporter
SynA1840_RS00505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_RS00550	COG0802	atpase or kinase
SynA1840_RS00555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynA1840_RS00560	COG0586	Pfam SNARE associated Golgi protein
SynA1840_RS00565	COG0629	single-stranded DNA binding
SynA1840_RS00590	COG0745	RESPONSE REGULATOR receiver
SynA1840_RS00595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynA1840_RS00615	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynA1840_RS00620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynA1840_RS00630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynA1840_RS00635	COG2255	four-way junction helicase activity
SynA1840_RS00645	COG1473	amidohydrolase
SynA1840_RS00660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynA1840_RS00665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynA1840_RS00670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynA1840_RS00675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA1840_RS00680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_RS00685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynA1840_RS00690	COG0598	Magnesium transport protein CorA
SynA1840_RS00695	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynA1840_RS00695	COG0662	Cupin 2, conserved barrel domain protein
SynA1840_RS00700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynA1840_RS00710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1840_RS00715	COG0571	ribonuclease III activity
SynA1840_RS00745	COG0058	SHG alpha-glucan phosphorylase activity
SynA1840_RS00750	COG0475	glutathione-regulated potassium exporter activity
SynA1840_RS00770	COG0277	FAD linked oxidase domain protein
SynA1840_RS00780	COG0247	lactate metabolic process
SynA1840_RS00800	COG0538	isocitrate dehydrogenase activity
SynA1840_RS00805	COG0463	Glycosyl transferase, family 2
SynA1840_RS00825	COG5398	heme oxygenase
SynA1840_RS00835	COG1132	(ABC) transporter
SynA1840_RS00840	COG0438	transferase activity, transferring glycosyl groups
SynA1840_RS00845	COG0438	transferase activity, transferring glycosyl groups
SynA1840_RS00850	COG0438	transferase activity, transferring glycosyl groups
SynA1840_RS00875	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynA1840_RS00910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynA1840_RS00920	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynA1840_RS00925	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynA1840_RS00925	COG0517	IMP dehydrogenase activity
SynA1840_RS00930	COG0617	tRNA 3'-terminal CCA addition
SynA1840_RS00930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynA1840_RS00930	COG0517	IMP dehydrogenase activity
SynA1840_RS00940	COG0709	Synthesizes selenophosphate from selenide and ATP
SynA1840_RS00945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA1840_RS00955	COG2274	protein secretion by the type I secretion system
SynA1840_RS00965	COG0438	transferase activity, transferring glycosyl groups
SynA1840_RS00975	COG0124	histidyl-tRNA synthetase
SynA1840_RS00980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1840_RS00985	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynA1840_RS01015	COG4447	cellulose binding
SynA1840_RS01020	COG1773	rubredoxin
SynA1840_RS01025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_RS01030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_RS01035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_RS01040	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynA1840_RS01055	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1840_RS01055	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1840_RS01070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SynA1840_RS01075	COG1132	(ABC) transporter
SynA1840_RS01080	COG0494	nUDIX hydrolase
SynA1840_RS01085	COG0415	Belongs to the DNA photolyase family
SynA1840_RS01115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynA1840_RS01120	COG0131	Imidazoleglycerol-phosphate dehydratase
SynA1840_RS01125	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynA1840_RS01135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynA1840_RS01155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1840_RS01160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1840_RS01170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynA1840_RS01175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynA1840_RS01190	COG1253	flavin adenine dinucleotide binding
SynA1840_RS01195	COG0673	inositol 2-dehydrogenase activity
SynA1840_RS01215	COG0343	queuine tRNA-ribosyltransferase activity
SynA1840_RS01225	COG2205	protein histidine kinase activity
SynA1840_RS01240	COG0138	bifunctional purine biosynthesis protein purh
SynA1840_RS01255	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynA1840_RS01260	COG0004	ammonium transporteR
SynA1840_RS01265	COG1489	DNA binding
SynA1840_RS01270	COG0728	peptidoglycan biosynthetic process
SynA1840_RS01295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynA1840_RS01300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1840_RS01305	COG1058	Belongs to the CinA family
SynA1840_RS01305	COG1546	Belongs to the CinA family
SynA1840_RS01310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynA1840_RS01315	COG0066	3-isopropylmalate dehydratase activity
SynA1840_RS01350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA1840_RS01355	COG0193	aminoacyl-tRNA hydrolase activity
SynA1840_RS01370	COG4372	Transposase
SynA1840_RS01375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1840_RS01380	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynA1840_RS01390	COG0717	Belongs to the dCTP deaminase family
SynA1840_RS01400	COG3118	belongs to the thioredoxin family
SynA1840_RS01405	COG0739	heme binding
SynA1840_RS01405	COG1196	nuclear chromosome segregation
SynA1840_RS01405	COG0741	lytic transglycosylase activity
SynA1840_RS01410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA1840_RS01415	COG2971	BadF BadG BcrA BcrD
SynA1840_RS01425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynA1840_RS01445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynA1840_RS01465	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1840_RS01470	COG1402	creatininase
SynA1840_RS01480	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynA1840_RS01490	COG2094	Belongs to the DNA glycosylase MPG family
SynA1840_RS01495	COG0540	Belongs to the ATCase OTCase family
SynA1840_RS01530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynA1840_RS01545	COG2046	Belongs to the sulfate adenylyltransferase family
SynA1840_RS01545	COG0529	Catalyzes the synthesis of activated sulfate
SynA1840_RS01550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_RS01555	COG0800	Aldolase
SynA1840_RS01565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynA1840_RS01595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1840_RS01615	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynA1840_RS01620	COG0719	Fe-S assembly protein
SynA1840_RS01625	COG0396	ATPase activity
SynA1840_RS01630	COG0719	Fe-S assembly protein
SynA1840_RS01635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynA1840_RS01645	COG0242	peptide deformylase activity
SynA1840_RS01665	COG0606	chelatase, subunit chli
SynA1840_RS01670	COG0537	adenosine 5'-monophosphoramidase activity
SynA1840_RS01675	COG4178	(ABC) transporter
SynA1840_RS01695	COG0515	serine threonine protein kinase
SynA1840_RS01710	COG0439	Biotin carboxylase
SynA1840_RS01720	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1840_RS01725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1840_RS01740	COG1196	nuclear chromosome segregation
SynA1840_RS01765	COG0116	Belongs to the methyltransferase superfamily
SynA1840_RS01845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1840_RS01925	COG2089	acid synthase
SynA1840_RS01945	COG1083	cytidylyl-transferase
SynA1840_RS01955	COG3562	capsule polysaccharide
SynA1840_RS01965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA1840_RS01980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynA1840_RS02060	COG0489	protein tyrosine kinase activity
SynA1840_RS02075	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynA1840_RS02080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA1840_RS02085	COG1132	(ABC) transporter
SynA1840_RS02090	COG1086	Polysaccharide biosynthesis protein
SynA1840_RS02105	COG2089	acid synthase
SynA1840_RS02120	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynA1840_RS02125	COG0463	Glycosyl transferase, family 2
SynA1840_RS02135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynA1840_RS02160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynA1840_RS02170	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SynA1840_RS02195	COG1215	transferase activity, transferring glycosyl groups
SynA1840_RS02225	COG0438	transferase activity, transferring glycosyl groups
SynA1840_RS02225	COG0297	glycogen (starch) synthase activity
SynA1840_RS02250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1840_RS02270	COG0347	Belongs to the P(II) protein family
SynA1840_RS02275	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynA1840_RS02315	COG1333	cytochrome c biogenesis protein
SynA1840_RS02335	COG0772	Belongs to the SEDS family
SynA1840_RS02405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1840_RS02410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1840_RS02420	COG0356	it plays a direct role in the translocation of protons across the membrane
SynA1840_RS02425	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1840_RS02430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1840_RS02435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA1840_RS02440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA1840_RS02445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynA1840_RS02450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynA1840_RS02460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1840_RS02470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1840_RS02475	COG3012	SEC-C Motif Domain Protein
SynA1840_RS02485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynA1840_RS02485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA1840_RS02490	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynA1840_RS02495	COG1160	GTP binding
SynA1840_RS02500	COG1253	flavin adenine dinucleotide binding
SynA1840_RS02505	COG0006	proline dipeptidase activity
SynA1840_RS02530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynA1840_RS02535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynA1840_RS02540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynA1840_RS02545	COG0459	protein refolding
SynA1840_RS02570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynA1840_RS02575	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynA1840_RS02590	COG0443	Heat shock 70 kDa protein
SynA1840_RS02625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynA1840_RS02645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynA1840_RS02650	COG2264	protein methyltransferase activity
SynA1840_RS02665	COG2010	Cytochrome c
SynA1840_RS02670	COG1234	tRNA 3'-trailer cleavage
SynA1840_RS02675	COG2385	sporulation resulting in formation of a cellular spore
SynA1840_RS02680	COG0363	glucosamine-6-phosphate deaminase activity
SynA1840_RS02695	COG0217	transcriptional regulatory protein
SynA1840_RS02700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynA1840_RS02705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1840_RS02710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynA1840_RS02715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynA1840_RS02725	COG4251	negative regulation of phosphorylation
SynA1840_RS02730	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynA1840_RS02735	COG5002	protein histidine kinase activity
SynA1840_RS02740	COG0151	Belongs to the GarS family
SynA1840_RS02750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynA1840_RS02760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynA1840_RS02765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynA1840_RS02770	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1840_RS02775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1840_RS02780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1840_RS02795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynA1840_RS02825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynA1840_RS02840	COG0284	orotidine-5'-phosphate decarboxylase activity
SynA1840_RS02875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynA1840_RS02905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynA1840_RS02910	COG2211	Major facilitator Superfamily
SynA1840_RS02930	COG0776	regulation of translation
SynA1840_RS02935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1840_RS02960	COG1053	succinate dehydrogenase
SynA1840_RS02990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynA1840_RS03000	COG0195	Participates in both transcription termination and antitermination
SynA1840_RS03005	COG0779	Required for maturation of 30S ribosomal subunits
SynA1840_RS03020	COG0641	radical SAM
SynA1840_RS03035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1840_RS03040	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynA1840_RS03045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynA1840_RS03050	COG0268	Binds directly to 16S ribosomal RNA
SynA1840_RS03055	COG0084	hydrolase, TatD family'
SynA1840_RS03060	COG0085	RNA polymerase activity
SynA1840_RS03065	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1840_RS03070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA1840_RS03080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynA1840_RS03130	COG0357	Ribosomal RNA small subunit methyltransferase G
SynA1840_RS03135	COG0484	heat shock protein binding
SynA1840_RS03145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynA1840_RS03160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynA1840_RS03180	COG0385	Bile acid
SynA1840_RS03185	COG4581	dead DEAH box helicase
SynA1840_RS03190	COG0114	fumarate hydratase activity
SynA1840_RS03210	COG1216	Glycosyl transferase, family 2
SynA1840_RS03210	COG0438	transferase activity, transferring glycosyl groups
SynA1840_RS03235	COG1216	Glycosyl transferase, family 2
SynA1840_RS03235	COG0438	transferase activity, transferring glycosyl groups
SynA1840_RS03240	COG1088	dTDP-glucose 4,6-dehydratase activity
SynA1840_RS03270	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynA1840_RS03280	COG1215	transferase activity, transferring glycosyl groups
SynA1840_RS03285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA1840_RS03295	COG1160	GTP binding
SynA1840_RS03300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynA1840_RS03310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynA1840_RS03315	COG1799	cell septum assembly
SynA1840_RS03320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynA1840_RS03325	COG0438	transferase activity, transferring glycosyl groups
SynA1840_RS03335	COG1381	Involved in DNA repair and RecF pathway recombination
SynA1840_RS03340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynA1840_RS03345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynA1840_RS03350	COG0321	lipoyl(octanoyl) transferase activity
SynA1840_RS03355	COG1022	Amp-dependent synthetase and ligase
SynA1840_RS03365	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA1840_RS03370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynA1840_RS03375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1840_RS03405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1840_RS03410	COG0440	acetolactate synthase activity
SynA1840_RS03415	COG2267	carboxylic ester hydrolase activity
SynA1840_RS03440	COG2226	methyltransferase
SynA1840_RS03450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynA1840_RS03455	COG0492	ferredoxin-NADP+ reductase activity
SynA1840_RS03510	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynA1840_RS03515	COG0733	neurotransmitter:sodium symporter activity
SynA1840_RS03525	COG0215	cysteine-tRNA ligase activity
SynA1840_RS03550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1840_RS03550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA1840_RS03555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynA1840_RS03560	COG0012	GTP binding
SynA1840_RS03575	COG0601	transmembrane transport
SynA1840_RS03590	COG0460	homoserine dehydrogenase
SynA1840_RS03595	COG2166	iron-sulfur cluster assembly
SynA1840_RS03605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynA1840_RS03610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynA1840_RS03615	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA1840_RS03630	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynA1840_RS03635	COG2010	Cytochrome c
SynA1840_RS03640	COG0742	ribosomal rna small subunit methyltransferase
SynA1840_RS03645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynA1840_RS03650	COG3118	belongs to the thioredoxin family
SynA1840_RS03655	COG0516	GMP reductase activity
SynA1840_RS03665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA1840_RS03670	COG0644	oxidoreductase
SynA1840_RS03675	COG1543	Belongs to the glycosyl hydrolase 57 family
SynA1840_RS03680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynA1840_RS03685	COG0395	ABC-type sugar transport system, permease component
SynA1840_RS03710	COG0011	TIGRFAM Protein of
SynA1840_RS03720	COG0564	pseudouridine synthase activity
SynA1840_RS03730	COG1480	7TM receptor with intracellular HD hydrolase
SynA1840_RS03735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynA1840_RS03745	COG0142	geranyltranstransferase activity
SynA1840_RS03755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA1840_RS03765	COG0406	alpha-ribazole phosphatase activity
SynA1840_RS03770	COG1254	Belongs to the acylphosphatase family
SynA1840_RS03775	COG1797	cobyrinic acid a,c-diamide synthase activity
SynA1840_RS03785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynA1840_RS03805	COG2205	protein histidine kinase activity
SynA1840_RS03820	COG0308	aminopeptidase N
SynA1840_RS03830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1840_RS03865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA1840_RS03875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1840_RS03900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SynA1840_RS03910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynA1840_RS03920	COG2197	response regulator
SynA1840_RS03925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA1840_RS03940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynA1840_RS03955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynA1840_RS03960	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA1840_RS03965	COG0473	3-isopropylmalate dehydrogenase activity
SynA1840_RS03970	COG3954	Phosphoribulokinase
SynA1840_RS03980	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynA1840_RS03985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynA1840_RS03995	COG0673	inositol 2-dehydrogenase activity
SynA1840_RS04000	COG0191	fructose-bisphosphate aldolase activity
SynA1840_RS04005	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1840_RS04010	COG0047	phosphoribosylformylglycinamidine synthase activity
SynA1840_RS04015	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA1840_RS04025	COG0668	transmembrane transport
SynA1840_RS04035	COG0640	Transcriptional regulator
SynA1840_RS04040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA1840_RS04085	COG5002	protein histidine kinase activity
SynA1840_RS04120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA1840_RS04135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1840_RS04145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynA1840_RS04150	COG1429	ligase activity, forming nitrogen-metal bonds
SynA1840_RS04180	COG4974	Belongs to the 'phage' integrase family
SynA1840_RS04210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynA1840_RS04215	COG0149	triose-phosphate isomerase activity
SynA1840_RS04220	COG2501	S4 domain
SynA1840_RS04225	COG1132	(ABC) transporter
SynA1840_RS04240	COG1115	amino acid carrier protein
SynA1840_RS04250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynA1840_RS04260	COG0799	negative regulation of ribosome biogenesis
SynA1840_RS04300	COG0659	secondary active sulfate transmembrane transporter activity
SynA1840_RS04305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynA1840_RS04310	COG4597	amino acid ABC transporter
SynA1840_RS04315	COG0765	amino acid transport
SynA1840_RS04355	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynA1840_RS04390	COG0625	glutathione transferase activity
SynA1840_RS04420	COG1799	cell septum assembly
SynA1840_RS04435	COG0735	belongs to the Fur family
SynA1840_RS04450	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynA1840_RS04485	COG0259	pyridoxamine-phosphate oxidase activity
SynA1840_RS04495	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynA1840_RS04530	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynA1840_RS04540	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynA1840_RS04565	COG0745	RESPONSE REGULATOR receiver
SynA1840_RS04570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynA1840_RS04575	COG0271	Belongs to the BolA IbaG family
SynA1840_RS04590	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynA1840_RS04610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynA1840_RS04630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA1840_RS04640	COG0513	Belongs to the DEAD box helicase family
SynA1840_RS04655	COG0724	RNA recognition motif
SynA1840_RS04660	COG1132	(ABC) transporter
SynA1840_RS04665	COG0475	glutathione-regulated potassium exporter activity
SynA1840_RS04665	COG0589	response to stress
SynA1840_RS04680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynA1840_RS04685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1840_RS04710	COG1054	Belongs to the UPF0176 family
SynA1840_RS04715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynA1840_RS04720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynA1840_RS04725	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynA1840_RS04730	COG0019	diaminopimelate decarboxylase activity
SynA1840_RS04735	COG0456	acetyltransferase
SynA1840_RS04740	COG0542	response to heat
SynA1840_RS04745	COG0371	Dehydrogenase
SynA1840_RS04750	COG0596	Alpha beta hydrolase
SynA1840_RS04760	COG0575	Belongs to the CDS family
SynA1840_RS04765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA1840_RS04770	COG1982	Orn Lys Arg decarboxylase major
SynA1840_RS04775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1840_RS04785	COG0745	RESPONSE REGULATOR receiver
SynA1840_RS04790	COG5002	protein histidine kinase activity
SynA1840_RS04795	COG1187	pseudouridine synthase activity
SynA1840_RS05365	COG2274	protein secretion by the type I secretion system
SynA1840_RS05375	COG1640	4-alpha-glucanotransferase
SynA1840_RS05395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynA1840_RS05410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1840_RS05415	COG1121	(ABC) transporter
SynA1840_RS05440	COG0701	Predicted permease
SynA1840_RS05490	COG0681	Belongs to the peptidase S26 family
SynA1840_RS05495	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynA1840_RS05500	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynA1840_RS05510	COG0297	glycogen (starch) synthase activity
SynA1840_RS05520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynA1840_RS05525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynA1840_RS05535	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynA1840_RS05540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynA1840_RS05545	COG2045	Belongs to the ComB family
SynA1840_RS05555	COG0860	N-Acetylmuramoyl-L-alanine amidase
SynA1840_RS05560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynA1840_RS05565	COG0142	geranyltranstransferase activity
SynA1840_RS05570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynA1840_RS05575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynA1840_RS05585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1840_RS05590	COG2176	DNA-directed DNA polymerase activity
SynA1840_RS05600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA1840_RS05605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1840_RS05625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA1840_RS05635	COG1132	(ABC) transporter
SynA1840_RS05645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1840_RS05650	COG0505	Belongs to the CarA family
SynA1840_RS05660	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynA1840_RS05665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1840_RS05675	COG0154	amidase activity
SynA1840_RS05680	COG0587	DNA-directed DNA polymerase activity
SynA1840_RS05690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynA1840_RS05695	COG0632	four-way junction helicase activity
SynA1840_RS05710	COG0358	DNA primase activity
SynA1840_RS05715	COG0798	PFAM Bile acid sodium symporter
SynA1840_RS05740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1840_RS05755	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynA1840_RS05770	COG0792	nuclease activity
SynA1840_RS05775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynA1840_RS05780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynA1840_RS05790	COG0022	dehydrogenase e1 component
SynA1840_RS05790	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA1840_RS05795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1840_RS05800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA1840_RS05860	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynA1840_RS05865	COG0515	serine threonine protein kinase
SynA1840_RS05890	COG2226	methyltransferase
SynA1840_RS05895	COG0174	glutamine synthetase
SynA1840_RS05905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynA1840_RS05925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynA1840_RS05945	COG0612	Peptidase, M16
SynA1840_RS05975	COG1216	Glycosyl transferase, family 2
SynA1840_RS05980	COG0052	Belongs to the universal ribosomal protein uS2 family
SynA1840_RS05985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynA1840_RS05995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynA1840_RS06000	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynA1840_RS06005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1840_RS06010	COG0751	glycine-tRNA ligase activity
SynA1840_RS06015	COG0644	oxidoreductase
SynA1840_RS06025	COG0826	peptidase U32
SynA1840_RS06030	COG1217	gtp-binding protein TYPA
SynA1840_RS06055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynA1840_RS06060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynA1840_RS06065	COG1494	fructose-1,6-bisphosphatase
SynA1840_RS06070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynA1840_RS06075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1840_RS06080	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynA1840_RS06085	COG0363	glucosamine-6-phosphate deaminase activity
SynA1840_RS06100	COG0129	dihydroxy-acid dehydratase activity
SynA1840_RS06110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynA1840_RS06145	COG0300	oxidoreductase activity
SynA1840_RS06220	COG4974	Belongs to the 'phage' integrase family
SynA1840_RS06250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynA1840_RS06255	COG4106	trans-aconitate 2-methyltransferase activity
SynA1840_RS06260	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynA1840_RS06280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynA1840_RS06305	COG1836	PFAM Integral membrane protein DUF92
SynA1840_RS06335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynA1840_RS06340	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynA1840_RS06345	COG0436	Aminotransferase
SynA1840_RS06355	COG1573	uracil-dna glycosylase
SynA1840_RS06360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynA1840_RS06365	COG0793	Belongs to the peptidase S41A family
SynA1840_RS06375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynA1840_RS06390	COG0861	Integral membrane protein TerC family
SynA1840_RS06410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynA1840_RS06420	COG0312	modulator of DNA gyrase
SynA1840_RS06425	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynA1840_RS06440	COG0163	prenyltransferase activity
SynA1840_RS06445	COG0557	exoribonuclease II activity
SynA1840_RS06455	COG2119	membrane
SynA1840_RS06470	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynA1840_RS06470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynA1840_RS06490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynA1840_RS06495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_RS06500	COG1615	UPF0182 protein
SynA1840_RS06505	COG0450	alkyl hydroperoxide reductase
SynA1840_RS06515	COG0739	heme binding
SynA1840_RS06520	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynA1840_RS06555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA1840_RS06560	COG0445	tRNA wobble uridine modification
SynA1840_RS06565	COG0557	exoribonuclease II activity
SynA1840_RS06570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynA1840_RS06575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynA1840_RS06580	COG0072	phenylalanine-tRNA ligase activity
SynA1840_RS06580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA1840_RS06585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynA1840_RS06640	COG0646	methionine synthase
SynA1840_RS06640	COG1410	methionine synthase
SynA1840_RS06645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynA1840_RS06660	COG0613	PHP domain protein
SynA1840_RS06665	COG1981	membrane
SynA1840_RS06670	COG3046	protein related to deoxyribodipyrimidine photolyase
SynA1840_RS06680	COG0322	excinuclease ABC activity
SynA1840_RS06690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynA1840_RS06700	COG2027	D-alanyl-D-alanine carboxypeptidase
SynA1840_RS06720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynA1840_RS06730	COG0495	leucyl-tRNA aminoacylation
SynA1840_RS06735	COG0166	Belongs to the GPI family
SynA1840_RS06765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynA1840_RS06770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynA1840_RS06775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1840_RS06775	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA1840_RS06780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA1840_RS06785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynA1840_RS06790	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynA1840_RS06800	COG0484	heat shock protein binding
SynA1840_RS06805	COG0443	Heat shock 70 kDa protein
SynA1840_RS06810	COG0573	inorganic phosphate transmembrane transporter activity
SynA1840_RS06815	COG0581	inorganic phosphate transmembrane transporter activity
SynA1840_RS06820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynA1840_RS06830	COG0633	Ferredoxin
SynA1840_RS06835	COG0483	inositol monophosphate 1-phosphatase activity
SynA1840_RS06840	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynA1840_RS06850	COG0326	Molecular chaperone. Has ATPase activity
SynA1840_RS06855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynA1840_RS06860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1840_RS06865	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynA1840_RS06870	COG1653	transport
SynA1840_RS06890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA1840_RS06915	COG0644	oxidoreductase
SynA1840_RS06920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynA1840_RS06925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynA1840_RS06950	COG0469	pyruvate kinase activity
SynA1840_RS06955	COG1136	(ABC) transporter
SynA1840_RS06955	COG0577	efflux transmembrane transporter activity
SynA1840_RS06960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_RS06975	COG0740	serine-type endopeptidase activity
SynA1840_RS06990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1840_RS07020	COG1175	transmembrane transport
SynA1840_RS07025	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynA1840_RS07085	COG1793	dna ligase
SynA1840_RS07090	COG1201	RNA secondary structure unwinding
SynA1840_RS07100	COG2059	Chromate
SynA1840_RS07140	COG2226	methyltransferase
SynA1840_RS07175	COG1119	ATPase activity
SynA1840_RS07185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1840_RS07200	COG1121	(ABC) transporter
SynA1840_RS07205	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA1840_RS07210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynA1840_RS07215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA1840_RS07305	COG0724	RNA recognition motif
SynA1840_RS07400	COG2197	response regulator
SynA1840_RS07415	COG2197	response regulator
SynA1840_RS07445	COG1487	ribonuclease activity
SynA1840_RS07505	COG0405	Gamma-glutamyltransferase
SynA1840_RS07600	COG2124	cytochrome p450
SynA1840_RS07630	COG0010	Belongs to the arginase family
SynA1840_RS07635	COG0375	protein maturation
SynA1840_RS07650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA1840_RS07655	COG1116	anion transmembrane transporter activity
SynA1840_RS07660	COG4638	Rieske (2fe-2S)
SynA1840_RS07680	COG2144	transferase activity, transferring acyl groups
SynA1840_RS07705	COG2072	flavoprotein involved in K transport
SynA1840_RS07800	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynA1840_RS07840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1840_RS07965	COG0180	Tryptophanyl-tRNA synthetase
SynA1840_RS07980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynA1840_RS07990	COG0837	glucose binding
SynA1840_RS07995	COG0083	homoserine kinase activity
SynA1840_RS08000	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_RS08005	COG0339	signal peptide processing
SynA1840_RS08020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynA1840_RS08060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynA1840_RS08065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynA1840_RS08075	COG3794	PFAM blue (type 1) copper domain protein
SynA1840_RS08105	COG0542	response to heat
SynA1840_RS08110	COG0720	synthase
SynA1840_RS08115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynA1840_RS08115	COG0140	phosphoribosyl-ATP diphosphatase activity
SynA1840_RS08135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_RS08170	COG2010	Cytochrome c
SynA1840_RS08185	COG0159	tryptophan synthase activity
SynA1840_RS08210	COG0418	dihydroorotase activity
SynA1840_RS08215	COG0659	secondary active sulfate transmembrane transporter activity
SynA1840_RS08220	COG0530	calcium, potassium:sodium antiporter activity
SynA1840_RS08240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1840_RS08255	COG0037	tRNA processing
SynA1840_RS08260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynA1840_RS08265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1840_RS08280	COG0456	acetyltransferase
SynA1840_RS08285	COG1132	(ABC) transporter
SynA1840_RS08290	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynA1840_RS08295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynA1840_RS08300	COG3842	ATPase activity
SynA1840_RS08305	COG0251	oxidation-reduction process
SynA1840_RS08510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA1840_RS08530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynA1840_RS08535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_RS08540	COG2135	peptidase activity
SynA1840_RS08555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1840_RS08555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA1840_RS08600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1840_RS08605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynA1840_RS08610	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynA1840_RS08620	COG0196	riboflavin kinase activity
SynA1840_RS08625	COG0352	thiamine-phosphate diphosphorylase activity
SynA1840_RS08645	COG1691	(AIR) carboxylase
SynA1840_RS08655	COG0336	Belongs to the RNA methyltransferase TrmD family
SynA1840_RS08670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynA1840_RS08680	COG0670	Belongs to the BI1 family
SynA1840_RS08685	COG1702	phosphate starvation-inducible protein PhoH
SynA1840_RS08690	COG0228	four-way junction DNA binding
SynA1840_RS08695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynA1840_RS08705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynA1840_RS08710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_RS08715	COG0482	sulfurtransferase activity
SynA1840_RS08720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynA1840_RS08750	COG0134	indole-3-glycerol-phosphate synthase activity
SynA1840_RS08755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA1840_RS08760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1840_RS08775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynA1840_RS08780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA1840_RS08785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA1840_RS08790	COG0285	dihydrofolate synthase activity
SynA1840_RS08820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1840_RS08825	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynA1840_RS08840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynA1840_RS08850	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynA1840_RS08855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynA1840_RS08860	COG4956	integral membrane protein (PIN domain superfamily)
SynA1840_RS08865	COG0740	serine-type endopeptidase activity
SynA1840_RS08870	COG0740	serine-type endopeptidase activity
SynA1840_RS08875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynA1840_RS08880	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynA1840_RS08910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SynA1840_RS09005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA1840_RS09045	COG0752	glycyl-tRNA synthetase alpha subunit
SynA1840_RS09065	COG2226	methyltransferase
SynA1840_RS09070	COG0107	imidazoleglycerol-phosphate synthase activity
SynA1840_RS09080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1840_RS09085	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynA1840_RS09090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA1840_RS09090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynA1840_RS09095	COG3695	enzyme binding
SynA1840_RS09100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA1840_RS09125	COG0481	GTPase activity
SynA1840_RS09135	COG0579	oxidoreductase
SynA1840_RS09140	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynA1840_RS09155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynA1840_RS09175	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynA1840_RS09180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynA1840_RS09215	COG0424	maF-like protein
SynA1840_RS09225	COG1492	cobalamin metabolic process
SynA1840_RS09255	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_RS09260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1840_RS09265	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1840_RS09290	COG4451	ribulose bisphosphate carboxylase, small
SynA1840_RS09295	COG1850	ribulose-bisphosphate carboxylase activity
SynA1840_RS09300	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1840_RS09305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA1840_RS09310	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA1840_RS09320	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1840_RS09325	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA1840_RS09330	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynA1840_RS09355	COG0730	response to heat
SynA1840_RS09360	COG0095	Lipoate-protein ligase
SynA1840_RS09365	COG0517	IMP dehydrogenase activity
SynA1840_RS09365	COG1994	Peptidase M50
SynA1840_RS09370	COG0135	phosphoribosylanthranilate isomerase activity
SynA1840_RS09375	COG0302	gtp cyclohydrolase
SynA1840_RS09380	COG4221	oxidoreductase activity
SynA1840_RS09385	COG0825	malonyl-CoA metabolic process
SynA1840_RS09390	COG5322	oxidoreductase activity
SynA1840_RS09395	COG3396	Phenylacetate-CoA oxygenase
SynA1840_RS09405	COG0539	negative regulation of cytoplasmic translation
SynA1840_RS09415	COG1496	oxidoreductase activity
SynA1840_RS09420	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynA1840_RS09440	COG0028	Belongs to the TPP enzyme family
SynA1840_RS09445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1840_RS09455	COG2226	methyltransferase
SynA1840_RS09470	COG0528	UMP kinase activity
SynA1840_RS09475	COG0233	cytoplasmic translational termination
SynA1840_RS09495	COG0415	Belongs to the DNA photolyase family
SynA1840_RS09505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynA1840_RS09510	COG0768	penicillin binding
SynA1840_RS09525	COG0588	phosphoglycerate mutase activity
SynA1840_RS09535	COG0681	Belongs to the peptidase S26 family
SynA1840_RS09555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1840_RS09570	COG0442	prolyl-tRNA aminoacylation
SynA1840_RS09580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynA1840_RS09585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynA1840_RS09600	COG0629	single-stranded DNA binding
SynA1840_RS09615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynA1840_RS09625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynA1840_RS09630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_RS09640	COG0181	hydroxymethylbilane synthase activity
SynA1840_RS09655	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA1840_RS09680	COG0432	Pfam Uncharacterised protein family UPF0047
SynA1840_RS09685	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynA1840_RS09690	COG0523	cobalamin synthesis protein
SynA1840_RS09700	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA1840_RS09725	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynA1840_RS09730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_RS09750	COG0708	Exodeoxyribonuclease III
SynA1840_RS09755	COG0277	FAD linked oxidase domain protein
SynA1840_RS09760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynA1840_RS09780	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynA1840_RS09790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA1840_RS09795	COG1666	GTP binding
SynA1840_RS09810	COG0857	belongs to the CobB CobQ family
SynA1840_RS09820	COG3000	fatty acid hydroxylase
SynA1840_RS09820	COG0300	oxidoreductase activity
SynA1840_RS09825	COG0024	Methionine aminopeptidase
SynA1840_RS09835	COG0335	large ribosomal subunit rRNA binding
SynA1840_RS09855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA1840_RS09875	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynA1840_RS09885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1840_RS09890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynA1840_RS09905	COG0194	GDP metabolic process
SynA1840_RS09910	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynA1840_RS09915	COG0805	protein transport
SynA1840_RS09925	COG0723	plastoquinol--plastocyanin reductase activity
SynA1840_RS09930	COG0739	heme binding
SynA1840_RS09935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynA1840_RS09940	COG2875	Belongs to the precorrin methyltransferase family
SynA1840_RS09955	COG0248	Ppx GppA phosphatase
SynA1840_RS09960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA1840_RS09965	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA1840_RS09970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynA1840_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
SynA1840_RS09995	COG0459	protein refolding
SynA1840_RS10000	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynA1840_RS10020	COG0109	protoheme IX farnesyltransferase activity
SynA1840_RS10025	COG1612	heme a metabolic process
SynA1840_RS10030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynA1840_RS10040	COG1845	cytochrome c oxidase, subunit III
SynA1840_RS10070	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynA1840_RS10085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynA1840_RS10090	COG1007	ATP synthesis coupled electron transport
SynA1840_RS10095	COG1136	(ABC) transporter
SynA1840_RS10095	COG0577	efflux transmembrane transporter activity
SynA1840_RS10105	COG2205	protein histidine kinase activity
SynA1840_RS10115	COG0745	RESPONSE REGULATOR receiver
SynA1840_RS10120	COG0739	heme binding
SynA1840_RS10130	COG0436	Aminotransferase
SynA1840_RS10135	COG3118	belongs to the thioredoxin family
SynA1840_RS10140	COG1842	Phage shock protein A
SynA1840_RS10150	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynA1840_RS10160	COG0697	spore germination
SynA1840_RS10165	COG0616	signal peptide processing
SynA1840_RS10180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynA1840_RS10185	COG0594	ribonuclease P activity
SynA1840_RS10195	COG0706	membrane insertase activity
SynA1840_RS10205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA1840_RS10215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynA1840_RS10220	COG0750	zinc metalloprotease
SynA1840_RS10225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynA1840_RS10230	COG1185	polyribonucleotide nucleotidyltransferase activity
SynA1840_RS10240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynA1840_RS10330	COG0322	excinuclease ABC activity
SynA1840_RS10385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynA1840_RS10390	COG2226	methyltransferase
SynA1840_RS10400	COG4176	ABC-type proline glycine betaine transport system permease component
SynA1840_RS10405	COG2113	Glycine betaine
SynA1840_RS10435	COG2988	succinylglutamate desuccinylase activity
SynA1840_RS10440	COG0435	Glutathione S-transferase
SynA1840_RS10450	COG0488	(ABC) transporter
SynA1840_RS10465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynA1840_RS10470	COG3842	ATPase activity
SynA1840_RS10475	COG1193	negative regulation of DNA recombination
SynA1840_RS10485	COG0113	porphobilinogen synthase activity
SynA1840_RS10490	COG0484	heat shock protein binding
SynA1840_RS10495	COG4243	Vitamin k epoxide reductase
SynA1840_RS10500	COG0659	secondary active sulfate transmembrane transporter activity
SynA1840_RS10510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynA1840_RS10555	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynA1840_RS10585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynA1840_RS10590	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynA1840_RS10600	COG1012	belongs to the aldehyde dehydrogenase family
SynA1840_RS10605	COG0741	lytic transglycosylase activity
SynA1840_RS10605	COG1388	LysM domain
SynA1840_RS10625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynA1840_RS10630	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynA1840_RS10635	COG0235	Class ii aldolase
SynA1840_RS10640	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynA1840_RS10675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1840_RS10680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA1840_RS10685	COG0793	Belongs to the peptidase S41A family
SynA1840_RS10690	COG1078	dGTPase activity
SynA1840_RS10695	COG0850	regulation of cytokinetic process
SynA1840_RS10700	COG2894	cell division
SynA1840_RS10705	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynA1840_RS10725	COG0009	L-threonylcarbamoyladenylate synthase
SynA1840_RS10730	COG2890	protein-(glutamine-N5) methyltransferase activity
SynA1840_RS10735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1840_RS10735	COG0758	DNA mediated transformation
SynA1840_RS10770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynA1840_RS10775	COG0539	negative regulation of cytoplasmic translation
SynA1840_RS10780	COG0546	phosphoglycolate phosphatase activity
SynA1840_RS10785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynA1840_RS10790	COG1070	Carbohydrate kinase
SynA1840_RS10805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA1840_RS10840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA1840_RS11015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynA1840_RS11020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynA1840_RS11020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynA1840_RS11025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA1840_RS11030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynA1840_RS11040	COG4989	oxidoreductase activity
SynA1840_RS11070	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynA1840_RS11090	COG0408	coproporphyrinogen oxidase activity
SynA1840_RS11095	COG0489	protein tyrosine kinase activity
SynA1840_RS11100	COG0772	Belongs to the SEDS family
SynA1840_RS11115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynA1840_RS11125	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynA1840_RS11140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynA1840_RS11145	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynA1840_RS11150	COG1606	tRNA processing
SynA1840_RS11155	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynA1840_RS11175	COG3001	Fructosamine kinase
SynA1840_RS11180	COG1233	COG1233 Phytoene dehydrogenase and related
SynA1840_RS11205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynA1840_RS11220	COG3854	ATPases associated with a variety of cellular activities
SynA1840_RS11235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynA1840_RS11240	COG0088	Forms part of the polypeptide exit tunnel
SynA1840_RS11245	COG0089	rRNA binding
SynA1840_RS11250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynA1840_RS11255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynA1840_RS11260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynA1840_RS11265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynA1840_RS11270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynA1840_RS11275	COG0255	Belongs to the universal ribosomal protein uL29 family
SynA1840_RS11280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynA1840_RS11285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynA1840_RS11290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynA1840_RS11295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynA1840_RS11300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynA1840_RS11305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynA1840_RS11310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynA1840_RS11315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynA1840_RS11320	COG0200	Binds to the 23S rRNA
SynA1840_RS11325	COG0201	protein transport
SynA1840_RS11330	COG0563	adenylate kinase activity
SynA1840_RS11335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynA1840_RS11340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynA1840_RS11345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynA1840_RS11350	COG0202	RNA polymerase activity
SynA1840_RS11355	COG0203	ribosomal protein L17
SynA1840_RS11360	COG0101	tRNA pseudouridine synthase activity
SynA1840_RS11365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynA1840_RS11370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynA1840_RS11375	COG0254	rRNA binding
SynA1840_RS11380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynA1840_RS11390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynA1840_RS11410	COG0463	Glycosyl transferase, family 2
SynA1840_RS11450	COG2885	chlorophyll binding
SynA1840_RS11455	COG2885	chlorophyll binding
SynA1840_RS11485	COG3659	wide pore channel activity
SynA1840_RS11495	COG3128	pkhd-type hydroxylase
SynA1840_RS11500	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA1840_RS11530	COG3659	wide pore channel activity
SynA1840_RS11550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA1840_RS11560	COG0069	glutamate synthase activity
SynA1840_RS11560	COG0070	glutamate synthase
SynA1840_RS11560	COG0067	glutamate synthase
SynA1840_RS11575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynA1840_RS11580	COG0049	tRNA binding
SynA1840_RS11585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynA1840_RS11590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynA1840_RS11595	COG0051	transcription antitermination factor activity, RNA binding
SynA1840_RS11600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynA1840_RS11605	COG2226	methyltransferase
SynA1840_RS11610	COG1605	Chorismate mutase
SynA1840_RS11610	COG0077	Prephenate dehydratase
SynA1840_RS11620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynA1840_RS11625	COG1530	ribonuclease E activity
SynA1840_RS11635	COG0436	Aminotransferase
SynA1840_RS11640	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA1840_RS11670	COG0033	Phosphoglucomutase
SynA1840_RS11680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynA1840_RS11690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynA1840_RS11710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA1840_RS11715	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynA1840_RS11720	COG0175	sulfate reduction
SynA1840_RS11725	COG1252	NADH dehydrogenase
SynA1840_RS11730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynA1840_RS11735	COG3273	potassium ion transport
SynA1840_RS11735	COG0471	metal ion transport
SynA1840_RS11740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynA1840_RS11745	COG0569	domain protein
SynA1840_RS11750	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynA1840_RS11775	COG0488	(ABC) transporter
SynA1840_RS11785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA1840_RS11800	COG1643	Atp-dependent helicase
SynA1840_RS11805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA1840_RS11815	COG1570	exodeoxyribonuclease VII activity
SynA1840_RS11820	COG1722	exodeoxyribonuclease VII activity
SynA1840_RS11880	COG1968	undecaprenyl-diphosphatase activity
SynA1840_RS11890	COG1555	photosystem II stabilization
SynA1840_RS11895	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynA1840_RS11900	COG4243	Vitamin k epoxide reductase
SynA1840_RS11905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA1840_RS11920	COG1032	radical SAM domain protein
SynA1840_RS11950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynA1840_RS11975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynA1840_RS11980	COG1472	Belongs to the glycosyl hydrolase 3 family
SynA1840_RS11985	COG0457	Tetratricopeptide repeat
SynA1840_RS11985	COG0463	Glycosyl transferase, family 2
SynA1840_RS11990	COG1587	Uroporphyrinogen-III synthase
SynA1840_RS12005	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1840_RS12010	COG0316	Belongs to the HesB IscA family
SynA1840_RS12030	COG1090	epimerase
SynA1840_RS12050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA1840_RS12055	COG3659	wide pore channel activity
SynA1840_RS12060	COG3659	wide pore channel activity
SynA1840_RS12065	COG3659	wide pore channel activity
SynA1840_RS12070	COG3659	wide pore channel activity
SynA1840_RS12105	COG1122	ATPase activity
SynA1840_RS12115	COG0745	RESPONSE REGULATOR receiver
SynA1840_RS12125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynA1840_RS12130	COG2217	Heavy metal translocating P-type atpase
SynA1840_RS12135	COG3063	Type IV pilus biogenesis stability protein PilW
SynA1840_RS12140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynA1840_RS12150	COG0416	fatty acid biosynthetic process
SynA1840_RS12155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynA1840_RS12160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynA1840_RS12175	COG1214	PFAM Peptidase M22, glycoprotease
SynA1840_RS12185	COG0617	tRNA 3'-terminal CCA addition
SynA1840_RS12190	COG0724	RNA recognition motif
SynA1840_RS12195	COG1562	ergosterol biosynthetic process
SynA1840_RS12200	COG0493	'glutamate synthase
SynA1840_RS12200	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA1840_RS12215	COG0583	DNA-binding transcription factor activity
SynA1840_RS12225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA1840_RS12230	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_RS12245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynA1840_RS12255	COG2197	response regulator
SynA1840_RS12265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA1840_RS12270	COG0713	ATP synthesis coupled electron transport
SynA1840_RS12275	COG0839	Belongs to the complex I subunit 6 family
SynA1840_RS12280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA1840_RS12285	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynA1840_RS12290	COG0372	Belongs to the citrate synthase family
SynA1840_RS12295	COG2062	phosphohistidine phosphatase, SixA
SynA1840_RS12310	COG1420	regulation of RNA biosynthetic process
SynA1840_RS12315	COG0133	tryptophan synthase activity
SynA1840_RS12320	COG0023	Translation Initiation Factor
SynA1840_RS12325	COG0529	Catalyzes the synthesis of activated sulfate
SynA1840_RS12330	COG0628	permease
SynA1840_RS12335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynA1840_RS12340	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SynA1840_RS12345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA1840_RS12350	COG0564	pseudouridine synthase activity
SynA1840_RS12355	COG0745	RESPONSE REGULATOR receiver
SynA1840_RS12365	COG1104	cysteine desulfurase activity
SynA1840_RS12395	COG0275	rRNA processing
SynA1840_RS12400	COG0649	NAD binding
SynA1840_RS12410	COG0824	Thioesterase
SynA1840_RS12445	COG0318	PFAM AMP-dependent synthetase and ligase
SynA1840_RS12455	COG1575	Belongs to the MenA family. Type 1 subfamily
SynA1840_RS12465	COG0189	ligase activity
SynA1840_RS12470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA1840_RS12485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynA1840_RS12490	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynA1840_RS12495	COG0512	Glutamine amidotransferase of anthranilate synthase
SynA1840_RS12505	COG0252	asparaginase activity
SynA1840_RS12510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA1840_RS12515	COG0018	arginyl-trna synthetase
SynA1840_RS12520	COG0157	Belongs to the NadC ModD family
SynA1840_RS12535	COG1475	DNA binding
SynA1840_RS12545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynA1840_RS12555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynA1840_RS12560	COG4172	Belongs to the ABC transporter superfamily
SynA1840_RS12565	COG0564	pseudouridine synthase activity
SynA1840_RS12575	COG0589	response to stress
SynA1840_RS12580	COG0126	phosphoglycerate kinase activity
SynA1840_RS12600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynA1840_RS12605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA1840_RS12645	COG0167	dihydroorotate dehydrogenase activity
SynA1840_RS12650	COG0328	RNA-DNA hybrid ribonuclease activity
SynA1840_RS12660	COG0222	ribosome binding
SynA1840_RS12665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynA1840_RS12670	COG0081	regulation of translation
SynA1840_RS12675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynA1840_RS12680	COG0250	Participates in transcription elongation, termination and antitermination
SynA1840_RS12685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynA1840_RS12690	COG0542	response to heat
SynA1840_RS12695	COG0346	lactoylglutathione lyase activity
SynA1840_RS12700	COG0148	phosphopyruvate hydratase activity
SynA1840_RS12705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1840_RS12725	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynA1840_RS12730	COG0237	dephospho-CoA kinase activity
SynA1840_RS12740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA1840_RS12745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynA1840_RS12745	COG2022	thiamine diphosphate biosynthetic process
SynA1840_RS12750	COG0105	UTP biosynthetic process
SynA1840_RS12755	COG1166	arginine decarboxylase activity
SynA1840_RS12760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynA1840_RS12770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynA1840_RS12785	COG0071	Belongs to the small heat shock protein (HSP20) family
SynA1840_RS12795	COG0426	domain, Protein
SynA1840_RS12795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1840_RS12800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA1840_RS12800	COG0426	domain, Protein
SynA1840_RS12810	COG1733	regulation of RNA biosynthetic process
SynA1840_RS12820	COG1741	Belongs to the pirin family
SynA1840_RS12835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA1840_RS12835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA1840_RS12840	COG0509	glycine decarboxylation via glycine cleavage system
SynA1840_RS12845	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynA1840_RS12855	COG0359	binds to the 23S rRNA
SynA1840_RS12860	COG1372	Participates in initiation and elongation during chromosome replication
SynA1840_RS12860	COG0305	Participates in initiation and elongation during chromosome replication
SynA1840_RS12860	COG1372	Participates in initiation and elongation during chromosome replication
SynA1840_RS12860	COG0305	Participates in initiation and elongation during chromosome replication
SynA1840_RS12875	COG0445	tRNA wobble uridine modification
SynA1840_RS12910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA1840_RS12925	COG0398	Pfam SNARE associated Golgi protein
SynA1840_RS12945	COG0525	valine-tRNA ligase activity
SynA1840_RS12965	COG4221	oxidoreductase activity
SynA1840_RS13060	COG3956	TIGRFAM MazG family protein
SynA1840_RS13070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynA1840_RS13075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynA1840_RS13080	COG0010	Belongs to the arginase family
SynA1840_RS13090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynA1840_RS13095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynA1840_RS13105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_RS13110	COG0504	CTP synthase activity
SynA1840_RS13115	COG0602	queuosine metabolic process
SynA1840_RS13120	COG2084	Dehydrogenase
SynA1840_RS13125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynA1840_RS13145	COG0366	Alpha amylase catalytic
SynA1840_RS13150	COG0463	Glycosyl transferase, family 2
SynA1840_RS13190	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynA1840_RS13195	COG0830	nickel cation binding
SynA1840_RS13200	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynA1840_RS13205	COG0829	nickel cation binding
SynA1840_RS13210	COG0831	urea catabolic process
SynA1840_RS13215	COG0832	Belongs to the urease beta subunit family
SynA1840_RS13220	COG0804	urea catabolic process
SynA1840_RS13240	COG0367	asparagine synthase
SynA1840_RS13245	COG0540	Belongs to the ATCase OTCase family
SynA1840_RS13260	COG2308	Evidence 4 Homologs of previously reported genes of
SynA1840_RS13280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynA1840_RS13285	COG0746	molybdenum cofactor guanylyltransferase activity
SynA1840_RS13290	COG2223	nitrite transmembrane transporter activity
SynA1840_RS13295	COG0243	molybdopterin cofactor binding
SynA1840_RS13315	COG0315	cyclic pyranopterin monophosphate synthase activity
SynA1840_RS13335	COG0314	molybdopterin synthase activity
SynA1840_RS13345	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynA1840_RS13350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynA1840_RS13360	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA1840_RS13370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA1840_RS13375	COG1121	(ABC) transporter
SynA1840_RS13380	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA1840_RS13385	COG0523	cobalamin synthesis protein
SynA1840_RS13400	COG1116	anion transmembrane transporter activity
SynA1840_RS13405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA1840_RS13410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SynA1840_RS13410	COG1116	anion transmembrane transporter activity
SynA1840_RS13415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA1840_RS13425	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynA1840_RS13435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA1840_RS13450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynA1840_RS13455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA1840_RS13460	COG0170	dolichyl monophosphate biosynthetic process
SynA1840_RS13470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynA1840_RS13475	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynA1840_RS13495	COG0788	formyltetrahydrofolate deformylase activity
SynA1840_RS13515	COG0443	Heat shock 70 kDa protein
SynA1840_RS13520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynA1840_RS13530	COG0360	Binds together with S18 to 16S ribosomal RNA
SynA1840_RS13540	COG0137	argininosuccinate synthase activity
SynA1840_RS13555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA1840_RS13570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynA1840_RS13575	COG0438	transferase activity, transferring glycosyl groups
SynA1840_RS13585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynA1840_RS13590	COG0497	DNA recombination
SynA1840_RS13595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA1840_RS13605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine