locus-tag	class	description
SynA18461_RS00005	COG0592	DNA-directed DNA polymerase activity
SynA18461_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA18461_RS00020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynA18461_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA18461_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynA18461_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA18461_RS00055	COG0552	protein localization to endoplasmic reticulum
SynA18461_RS00060	COG2208	phosphoserine phosphatase activity
SynA18461_RS00065	COG0165	Argininosuccinate lyase
SynA18461_RS00070	COG0724	RNA recognition motif
SynA18461_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynA18461_RS00080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA18461_RS00085	COG2081	HI0933 family
SynA18461_RS00090	COG1459	type II secretion system
SynA18461_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynA18461_RS00105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynA18461_RS00110	COG0484	heat shock protein binding
SynA18461_RS00120	COG1162	GTPase activity
SynA18461_RS00125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynA18461_RS00130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynA18461_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynA18461_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA18461_RS00145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynA18461_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA18461_RS00155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynA18461_RS00160	COG0511	ligase activity, forming carbon-carbon bonds
SynA18461_RS00165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynA18461_RS00230	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynA18461_RS00235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynA18461_RS00235	COG0519	Catalyzes the synthesis of GMP from XMP
SynA18461_RS00250	COG0768	penicillin binding
SynA18461_RS00255	COG0438	transferase activity, transferring glycosyl groups
SynA18461_RS00260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA18461_RS00270	COG2022	thiamine diphosphate biosynthetic process
SynA18461_RS00285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynA18461_RS00290	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynA18461_RS00295	COG2385	sporulation resulting in formation of a cellular spore
SynA18461_RS00300	COG1215	transferase activity, transferring glycosyl groups
SynA18461_RS00305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynA18461_RS00315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynA18461_RS00320	COG0740	serine-type endopeptidase activity
SynA18461_RS00325	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynA18461_RS00330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynA18461_RS00335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynA18461_RS00340	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynA18461_RS00370	COG2082	Precorrin-8x methylmutase
SynA18461_RS00375	COG0037	tRNA processing
SynA18461_RS00385	COG0556	nucleotide-excision repair
SynA18461_RS00390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynA18461_RS00410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynA18461_RS00435	COG0653	protein targeting
SynA18461_RS00455	COG1045	serine acetyltransferase
SynA18461_RS00460	COG1725	Transcriptional regulator
SynA18461_RS00465	COG0412	Dienelactone hydrolase
SynA18461_RS00470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynA18461_RS00475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynA18461_RS00480	COG1372	Participates in initiation and elongation during chromosome replication
SynA18461_RS00480	COG0187	DNA topoisomerase II activity
SynA18461_RS00490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA18461_RS00495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynA18461_RS00500	COG0386	Belongs to the glutathione peroxidase family
SynA18461_RS00510	COG2239	Acts as a magnesium transporter
SynA18461_RS00515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_RS00535	COG0714	Associated with various cellular activities
SynA18461_RS00585	COG0802	atpase or kinase
SynA18461_RS00590	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynA18461_RS00595	COG0586	Pfam SNARE associated Golgi protein
SynA18461_RS00600	COG0629	single-stranded DNA binding
SynA18461_RS00625	COG0745	RESPONSE REGULATOR receiver
SynA18461_RS00630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynA18461_RS00650	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynA18461_RS00655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynA18461_RS00665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynA18461_RS00670	COG2255	four-way junction helicase activity
SynA18461_RS00680	COG1473	amidohydrolase
SynA18461_RS00695	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynA18461_RS00700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynA18461_RS00705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynA18461_RS00710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA18461_RS00715	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_RS00720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynA18461_RS00725	COG0598	Magnesium transport protein CorA
SynA18461_RS00735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynA18461_RS00745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_RS00750	COG0571	ribonuclease III activity
SynA18461_RS00775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynA18461_RS00780	COG0058	SHG alpha-glucan phosphorylase activity
SynA18461_RS00785	COG0475	glutathione-regulated potassium exporter activity
SynA18461_RS00805	COG0277	FAD linked oxidase domain protein
SynA18461_RS00815	COG0247	lactate metabolic process
SynA18461_RS00830	COG0538	isocitrate dehydrogenase activity
SynA18461_RS00835	COG0463	Glycosyl transferase, family 2
SynA18461_RS00845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SynA18461_RS00855	COG5398	heme oxygenase
SynA18461_RS00865	COG1132	(ABC) transporter
SynA18461_RS00870	COG0438	transferase activity, transferring glycosyl groups
SynA18461_RS00905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynA18461_RS00975	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynA18461_RS00985	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynA18461_RS00990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynA18461_RS00990	COG0517	IMP dehydrogenase activity
SynA18461_RS00995	COG0617	tRNA 3'-terminal CCA addition
SynA18461_RS00995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynA18461_RS00995	COG0517	IMP dehydrogenase activity
SynA18461_RS01005	COG0709	Synthesizes selenophosphate from selenide and ATP
SynA18461_RS01010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynA18461_RS01020	COG2274	protein secretion by the type I secretion system
SynA18461_RS01030	COG0438	transferase activity, transferring glycosyl groups
SynA18461_RS01040	COG0124	histidyl-tRNA synthetase
SynA18461_RS01045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynA18461_RS01050	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynA18461_RS01080	COG4447	cellulose binding
SynA18461_RS01085	COG1773	rubredoxin
SynA18461_RS01090	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_RS01095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_RS01100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_RS01105	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynA18461_RS01120	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA18461_RS01120	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA18461_RS01135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SynA18461_RS01140	COG1132	(ABC) transporter
SynA18461_RS01145	COG0494	nUDIX hydrolase
SynA18461_RS01150	COG0415	Belongs to the DNA photolyase family
SynA18461_RS01180	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynA18461_RS01185	COG0131	Imidazoleglycerol-phosphate dehydratase
SynA18461_RS01190	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynA18461_RS01200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynA18461_RS01220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA18461_RS01225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA18461_RS01235	COG0354	folic acid binding
SynA18461_RS01240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynA18461_RS01255	COG1253	flavin adenine dinucleotide binding
SynA18461_RS01260	COG0673	inositol 2-dehydrogenase activity
SynA18461_RS01280	COG0343	queuine tRNA-ribosyltransferase activity
SynA18461_RS01290	COG2205	protein histidine kinase activity
SynA18461_RS01305	COG0138	bifunctional purine biosynthesis protein purh
SynA18461_RS01320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynA18461_RS01325	COG0004	ammonium transporteR
SynA18461_RS01330	COG1489	DNA binding
SynA18461_RS01335	COG0728	peptidoglycan biosynthetic process
SynA18461_RS01360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynA18461_RS01365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA18461_RS01370	COG1058	Belongs to the CinA family
SynA18461_RS01370	COG1546	Belongs to the CinA family
SynA18461_RS01375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynA18461_RS01380	COG0066	3-isopropylmalate dehydratase activity
SynA18461_RS01415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA18461_RS01420	COG0193	aminoacyl-tRNA hydrolase activity
SynA18461_RS01435	COG4372	Transposase
SynA18461_RS01440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_RS01445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynA18461_RS01455	COG0717	Belongs to the dCTP deaminase family
SynA18461_RS01465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA18461_RS01470	COG0739	heme binding
SynA18461_RS01470	COG0741	lytic transglycosylase activity
SynA18461_RS01470	COG1196	nuclear chromosome segregation
SynA18461_RS01475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynA18461_RS01480	COG2971	BadF BadG BcrA BcrD
SynA18461_RS01490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynA18461_RS01510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynA18461_RS01530	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA18461_RS01535	COG1402	creatininase
SynA18461_RS01545	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynA18461_RS01550	COG2094	Belongs to the DNA glycosylase MPG family
SynA18461_RS01555	COG0540	Belongs to the ATCase OTCase family
SynA18461_RS01590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynA18461_RS01605	COG2046	Belongs to the sulfate adenylyltransferase family
SynA18461_RS01605	COG0529	Catalyzes the synthesis of activated sulfate
SynA18461_RS01610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_RS01615	COG0800	Aldolase
SynA18461_RS01625	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynA18461_RS01645	COG4974	Belongs to the 'phage' integrase family
SynA18461_RS01670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynA18461_RS01690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA18461_RS01710	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynA18461_RS01715	COG0719	Fe-S assembly protein
SynA18461_RS01720	COG0396	ATPase activity
SynA18461_RS01725	COG0719	Fe-S assembly protein
SynA18461_RS01730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynA18461_RS01740	COG0242	peptide deformylase activity
SynA18461_RS01760	COG0606	chelatase, subunit chli
SynA18461_RS01765	COG0537	adenosine 5'-monophosphoramidase activity
SynA18461_RS01770	COG4178	(ABC) transporter
SynA18461_RS01790	COG0515	serine threonine protein kinase
SynA18461_RS01805	COG0439	Biotin carboxylase
SynA18461_RS01815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA18461_RS01835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA18461_RS01850	COG1196	nuclear chromosome segregation
SynA18461_RS01875	COG0116	Belongs to the methyltransferase superfamily
SynA18461_RS02020	COG2089	acid synthase
SynA18461_RS02040	COG1083	cytidylyl-transferase
SynA18461_RS02050	COG3562	capsule polysaccharide
SynA18461_RS02060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynA18461_RS02075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynA18461_RS02110	COG2274	protein secretion by the type I secretion system
SynA18461_RS02130	COG0438	transferase activity, transferring glycosyl groups
SynA18461_RS02165	COG1132	(ABC) transporter
SynA18461_RS02170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SynA18461_RS02180	COG2089	acid synthase
SynA18461_RS02190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SynA18461_RS02200	COG2226	methyltransferase
SynA18461_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
SynA18461_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
SynA18461_RS02230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA18461_RS02240	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynA18461_RS02260	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynA18461_RS02295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA18461_RS02320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynA18461_RS02365	COG1333	cytochrome c biogenesis protein
SynA18461_RS02385	COG0772	Belongs to the SEDS family
SynA18461_RS02430	COG2161	toxin-antitoxin pair type II binding
SynA18461_RS02455	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA18461_RS02460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA18461_RS02470	COG0356	it plays a direct role in the translocation of protons across the membrane
SynA18461_RS02475	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA18461_RS02480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA18461_RS02485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynA18461_RS02490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynA18461_RS02495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynA18461_RS02500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynA18461_RS02510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA18461_RS02520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA18461_RS02525	COG3012	SEC-C Motif Domain Protein
SynA18461_RS02535	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynA18461_RS02535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynA18461_RS02540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynA18461_RS02545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynA18461_RS02550	COG1253	flavin adenine dinucleotide binding
SynA18461_RS02555	COG0006	proline dipeptidase activity
SynA18461_RS02575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynA18461_RS02580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynA18461_RS02585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynA18461_RS02590	COG0459	protein refolding
SynA18461_RS02610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynA18461_RS02615	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynA18461_RS02630	COG0443	Heat shock 70 kDa protein
SynA18461_RS02665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynA18461_RS02685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynA18461_RS02690	COG2264	protein methyltransferase activity
SynA18461_RS02705	COG2010	Cytochrome c
SynA18461_RS02710	COG1234	tRNA 3'-trailer cleavage
SynA18461_RS02715	COG2385	sporulation resulting in formation of a cellular spore
SynA18461_RS02720	COG0363	glucosamine-6-phosphate deaminase activity
SynA18461_RS02735	COG0217	transcriptional regulatory protein
SynA18461_RS02740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynA18461_RS02750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynA18461_RS02755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynA18461_RS02765	COG4251	negative regulation of phosphorylation
SynA18461_RS02770	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynA18461_RS02775	COG5002	protein histidine kinase activity
SynA18461_RS02780	COG0151	Belongs to the GarS family
SynA18461_RS02790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynA18461_RS02800	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynA18461_RS02805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynA18461_RS02810	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA18461_RS02815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA18461_RS02820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA18461_RS02835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynA18461_RS02855	COG2197	response regulator
SynA18461_RS02865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynA18461_RS02880	COG0284	orotidine-5'-phosphate decarboxylase activity
SynA18461_RS02915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynA18461_RS02940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynA18461_RS02945	COG2211	Major facilitator Superfamily
SynA18461_RS02965	COG0776	regulation of translation
SynA18461_RS02970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA18461_RS02990	COG1053	succinate dehydrogenase
SynA18461_RS03020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynA18461_RS03030	COG0195	Participates in both transcription termination and antitermination
SynA18461_RS03035	COG0779	Required for maturation of 30S ribosomal subunits
SynA18461_RS03050	COG0641	radical SAM
SynA18461_RS03070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA18461_RS03075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynA18461_RS03080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynA18461_RS03085	COG0268	Binds directly to 16S ribosomal RNA
SynA18461_RS03090	COG0084	hydrolase, TatD family'
SynA18461_RS03095	COG0085	RNA polymerase activity
SynA18461_RS03100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA18461_RS03105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynA18461_RS03115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynA18461_RS03160	COG0357	Ribosomal RNA small subunit methyltransferase G
SynA18461_RS03165	COG0484	heat shock protein binding
SynA18461_RS03175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynA18461_RS03190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynA18461_RS03210	COG0385	Bile acid
SynA18461_RS03215	COG4581	dead DEAH box helicase
SynA18461_RS03220	COG0114	fumarate hydratase activity
SynA18461_RS03240	COG0438	transferase activity, transferring glycosyl groups
SynA18461_RS03240	COG1216	Glycosyl transferase, family 2
SynA18461_RS03260	COG0438	transferase activity, transferring glycosyl groups
SynA18461_RS03260	COG1216	Glycosyl transferase, family 2
SynA18461_RS03265	COG1088	dTDP-glucose 4,6-dehydratase activity
SynA18461_RS03295	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynA18461_RS03305	COG1215	transferase activity, transferring glycosyl groups
SynA18461_RS03320	COG1160	GTP binding
SynA18461_RS03325	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynA18461_RS03335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynA18461_RS03340	COG1799	cell septum assembly
SynA18461_RS03345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynA18461_RS03350	COG0438	transferase activity, transferring glycosyl groups
SynA18461_RS03360	COG1381	Involved in DNA repair and RecF pathway recombination
SynA18461_RS03365	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynA18461_RS03370	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynA18461_RS03375	COG0321	lipoyl(octanoyl) transferase activity
SynA18461_RS03380	COG1022	Amp-dependent synthetase and ligase
SynA18461_RS03390	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA18461_RS03395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynA18461_RS03400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA18461_RS03430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA18461_RS03435	COG0440	acetolactate synthase activity
SynA18461_RS03440	COG2267	carboxylic ester hydrolase activity
SynA18461_RS03465	COG2226	methyltransferase
SynA18461_RS03475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynA18461_RS03480	COG0492	ferredoxin-NADP+ reductase activity
SynA18461_RS03535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynA18461_RS03540	COG0733	neurotransmitter:sodium symporter activity
SynA18461_RS03550	COG0215	cysteine-tRNA ligase activity
SynA18461_RS03560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA18461_RS03560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynA18461_RS03565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynA18461_RS03570	COG0012	GTP binding
SynA18461_RS03585	COG0601	transmembrane transport
SynA18461_RS03590	COG4533	DNA binding
SynA18461_RS03600	COG0460	homoserine dehydrogenase
SynA18461_RS03605	COG2166	iron-sulfur cluster assembly
SynA18461_RS03615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynA18461_RS03620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynA18461_RS03625	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynA18461_RS03640	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynA18461_RS03645	COG2010	Cytochrome c
SynA18461_RS03650	COG0742	ribosomal rna small subunit methyltransferase
SynA18461_RS03655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynA18461_RS03660	COG3118	belongs to the thioredoxin family
SynA18461_RS03665	COG0516	GMP reductase activity
SynA18461_RS03675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynA18461_RS03680	COG0644	oxidoreductase
SynA18461_RS03685	COG1543	Belongs to the glycosyl hydrolase 57 family
SynA18461_RS03690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynA18461_RS03695	COG0395	ABC-type sugar transport system, permease component
SynA18461_RS03720	COG0011	TIGRFAM Protein of
SynA18461_RS03730	COG0564	pseudouridine synthase activity
SynA18461_RS03740	COG1480	7TM receptor with intracellular HD hydrolase
SynA18461_RS03745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynA18461_RS03755	COG0142	geranyltranstransferase activity
SynA18461_RS03765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA18461_RS03775	COG0406	alpha-ribazole phosphatase activity
SynA18461_RS03780	COG1254	Belongs to the acylphosphatase family
SynA18461_RS03785	COG1797	cobyrinic acid a,c-diamide synthase activity
SynA18461_RS03795	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynA18461_RS03815	COG2205	protein histidine kinase activity
SynA18461_RS03830	COG0308	aminopeptidase N
SynA18461_RS03845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA18461_RS03880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA18461_RS03890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_RS03915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SynA18461_RS03925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynA18461_RS03935	COG2197	response regulator
SynA18461_RS03940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynA18461_RS03955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynA18461_RS03970	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynA18461_RS03975	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynA18461_RS03980	COG0473	3-isopropylmalate dehydrogenase activity
SynA18461_RS03985	COG3954	Phosphoribulokinase
SynA18461_RS03995	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynA18461_RS04000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynA18461_RS04010	COG0673	inositol 2-dehydrogenase activity
SynA18461_RS04015	COG0191	fructose-bisphosphate aldolase activity
SynA18461_RS04020	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA18461_RS04025	COG0047	phosphoribosylformylglycinamidine synthase activity
SynA18461_RS04030	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynA18461_RS04040	COG0668	transmembrane transport
SynA18461_RS04050	COG0640	Transcriptional regulator
SynA18461_RS04055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynA18461_RS04100	COG5002	protein histidine kinase activity
SynA18461_RS04135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA18461_RS04150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA18461_RS04160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynA18461_RS04165	COG1429	ligase activity, forming nitrogen-metal bonds
SynA18461_RS04175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynA18461_RS04180	COG0149	triose-phosphate isomerase activity
SynA18461_RS04185	COG2501	S4 domain
SynA18461_RS04190	COG1132	(ABC) transporter
SynA18461_RS04205	COG1115	amino acid carrier protein
SynA18461_RS04215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynA18461_RS04225	COG0799	negative regulation of ribosome biogenesis
SynA18461_RS04265	COG0659	secondary active sulfate transmembrane transporter activity
SynA18461_RS04270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynA18461_RS04275	COG4597	amino acid ABC transporter
SynA18461_RS04280	COG0765	amino acid transport
SynA18461_RS04320	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynA18461_RS04355	COG0625	glutathione transferase activity
SynA18461_RS04385	COG1799	cell septum assembly
SynA18461_RS04400	COG0735	belongs to the Fur family
SynA18461_RS04415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynA18461_RS04450	COG0259	pyridoxamine-phosphate oxidase activity
SynA18461_RS04460	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynA18461_RS04505	COG4106	trans-aconitate 2-methyltransferase activity
SynA18461_RS04615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynA18461_RS04625	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynA18461_RS04650	COG0745	RESPONSE REGULATOR receiver
SynA18461_RS04660	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynA18461_RS04665	COG0271	Belongs to the BolA IbaG family
SynA18461_RS04680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynA18461_RS04695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SynA18461_RS04700	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynA18461_RS04720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynA18461_RS04730	COG0513	Belongs to the DEAD box helicase family
SynA18461_RS04745	COG0724	RNA recognition motif
SynA18461_RS04750	COG1132	(ABC) transporter
SynA18461_RS04755	COG0475	glutathione-regulated potassium exporter activity
SynA18461_RS04755	COG0589	response to stress
SynA18461_RS04770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynA18461_RS04775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA18461_RS04800	COG1054	Belongs to the UPF0176 family
SynA18461_RS04805	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynA18461_RS04810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynA18461_RS04815	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynA18461_RS04820	COG0019	diaminopimelate decarboxylase activity
SynA18461_RS04825	COG0456	acetyltransferase
SynA18461_RS04830	COG0542	response to heat
SynA18461_RS04835	COG0371	Dehydrogenase
SynA18461_RS04840	COG0596	Alpha beta hydrolase
SynA18461_RS04850	COG0575	Belongs to the CDS family
SynA18461_RS04855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA18461_RS04860	COG1982	Orn Lys Arg decarboxylase major
SynA18461_RS04865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA18461_RS04875	COG0745	RESPONSE REGULATOR receiver
SynA18461_RS04880	COG5002	protein histidine kinase activity
SynA18461_RS04885	COG1187	pseudouridine synthase activity
SynA18461_RS05025	COG2274	protein secretion by the type I secretion system
SynA18461_RS05035	COG1640	4-alpha-glucanotransferase
SynA18461_RS05055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynA18461_RS05070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA18461_RS05075	COG1121	(ABC) transporter
SynA18461_RS05100	COG0701	Predicted permease
SynA18461_RS05205	COG0681	Belongs to the peptidase S26 family
SynA18461_RS05210	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynA18461_RS05215	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynA18461_RS05220	COG1376	ErfK ybiS ycfS ynhG family protein
SynA18461_RS05225	COG0297	glycogen (starch) synthase activity
SynA18461_RS05235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynA18461_RS05240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynA18461_RS05250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynA18461_RS05255	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynA18461_RS05260	COG2045	Belongs to the ComB family
SynA18461_RS05270	COG0860	N-Acetylmuramoyl-L-alanine amidase
SynA18461_RS05275	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynA18461_RS05280	COG0142	geranyltranstransferase activity
SynA18461_RS05285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynA18461_RS05290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynA18461_RS05300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA18461_RS05305	COG2176	DNA-directed DNA polymerase activity
SynA18461_RS05315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA18461_RS05320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_RS05340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynA18461_RS05350	COG1132	(ABC) transporter
SynA18461_RS05360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA18461_RS05365	COG0505	Belongs to the CarA family
SynA18461_RS05375	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynA18461_RS05380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA18461_RS05390	COG0154	amidase activity
SynA18461_RS05395	COG0587	DNA-directed DNA polymerase activity
SynA18461_RS05405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynA18461_RS05410	COG0632	four-way junction helicase activity
SynA18461_RS05425	COG0358	DNA primase activity
SynA18461_RS05430	COG0798	PFAM Bile acid sodium symporter
SynA18461_RS05455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA18461_RS05470	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynA18461_RS05540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynA18461_RS05545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynA18461_RS05555	COG0022	dehydrogenase e1 component
SynA18461_RS05555	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynA18461_RS05560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA18461_RS05565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynA18461_RS05620	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynA18461_RS05625	COG0515	serine threonine protein kinase
SynA18461_RS05650	COG2226	methyltransferase
SynA18461_RS05655	COG0174	glutamine synthetase
SynA18461_RS05665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynA18461_RS05685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynA18461_RS05705	COG0612	Peptidase, M16
SynA18461_RS05735	COG1216	Glycosyl transferase, family 2
SynA18461_RS05740	COG0052	Belongs to the universal ribosomal protein uS2 family
SynA18461_RS05745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynA18461_RS05755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynA18461_RS05760	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynA18461_RS05765	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA18461_RS05770	COG0751	glycine-tRNA ligase activity
SynA18461_RS05780	COG0644	oxidoreductase
SynA18461_RS05790	COG0826	peptidase U32
SynA18461_RS05795	COG1217	gtp-binding protein TYPA
SynA18461_RS05820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynA18461_RS05825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynA18461_RS05830	COG1494	fructose-1,6-bisphosphatase
SynA18461_RS05835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynA18461_RS05840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA18461_RS05845	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynA18461_RS05850	COG0363	glucosamine-6-phosphate deaminase activity
SynA18461_RS05865	COG0129	dihydroxy-acid dehydratase activity
SynA18461_RS05875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynA18461_RS05910	COG0300	oxidoreductase activity
SynA18461_RS06075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynA18461_RS06080	COG4106	trans-aconitate 2-methyltransferase activity
SynA18461_RS06085	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynA18461_RS06105	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynA18461_RS06130	COG1836	PFAM Integral membrane protein DUF92
SynA18461_RS06160	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynA18461_RS06165	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynA18461_RS06170	COG0436	Aminotransferase
SynA18461_RS06180	COG1573	uracil-dna glycosylase
SynA18461_RS06185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynA18461_RS06190	COG0793	Belongs to the peptidase S41A family
SynA18461_RS06200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynA18461_RS06220	COG0861	Integral membrane protein TerC family
SynA18461_RS06240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynA18461_RS06250	COG0312	modulator of DNA gyrase
SynA18461_RS06255	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynA18461_RS06270	COG0163	prenyltransferase activity
SynA18461_RS06275	COG0557	exoribonuclease II activity
SynA18461_RS06285	COG2119	membrane
SynA18461_RS06300	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynA18461_RS06300	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynA18461_RS06320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynA18461_RS06325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_RS06330	COG1615	UPF0182 protein
SynA18461_RS06335	COG0450	alkyl hydroperoxide reductase
SynA18461_RS06345	COG0739	heme binding
SynA18461_RS06350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynA18461_RS06385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA18461_RS06390	COG0445	tRNA wobble uridine modification
SynA18461_RS06395	COG0557	exoribonuclease II activity
SynA18461_RS06400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynA18461_RS06405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynA18461_RS06410	COG0072	phenylalanine-tRNA ligase activity
SynA18461_RS06410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynA18461_RS06415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynA18461_RS06475	COG1410	methionine synthase
SynA18461_RS06475	COG0646	methionine synthase
SynA18461_RS06480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynA18461_RS06500	COG1981	membrane
SynA18461_RS06505	COG3046	protein related to deoxyribodipyrimidine photolyase
SynA18461_RS06515	COG0322	excinuclease ABC activity
SynA18461_RS06525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynA18461_RS06535	COG2027	D-alanyl-D-alanine carboxypeptidase
SynA18461_RS06555	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynA18461_RS06565	COG0495	leucyl-tRNA aminoacylation
SynA18461_RS06570	COG0166	Belongs to the GPI family
SynA18461_RS06595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynA18461_RS06600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynA18461_RS06605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA18461_RS06605	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynA18461_RS06610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynA18461_RS06615	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynA18461_RS06620	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynA18461_RS06630	COG0484	heat shock protein binding
SynA18461_RS06635	COG0443	Heat shock 70 kDa protein
SynA18461_RS06640	COG0573	inorganic phosphate transmembrane transporter activity
SynA18461_RS06645	COG0581	inorganic phosphate transmembrane transporter activity
SynA18461_RS06650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynA18461_RS06675	COG0633	Ferredoxin
SynA18461_RS06680	COG0483	inositol monophosphate 1-phosphatase activity
SynA18461_RS06685	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynA18461_RS06695	COG0326	Molecular chaperone. Has ATPase activity
SynA18461_RS06700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynA18461_RS06705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA18461_RS06710	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynA18461_RS06715	COG1653	transport
SynA18461_RS06760	COG0644	oxidoreductase
SynA18461_RS06765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynA18461_RS06770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynA18461_RS06795	COG0469	pyruvate kinase activity
SynA18461_RS06800	COG1136	(ABC) transporter
SynA18461_RS06800	COG0577	efflux transmembrane transporter activity
SynA18461_RS06805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_RS06820	COG0740	serine-type endopeptidase activity
SynA18461_RS06835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA18461_RS06860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynA18461_RS06865	COG1175	transmembrane transport
SynA18461_RS06870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynA18461_RS06930	COG1793	dna ligase
SynA18461_RS06935	COG1201	RNA secondary structure unwinding
SynA18461_RS06945	COG2059	Chromate
SynA18461_RS06990	COG2226	methyltransferase
SynA18461_RS07025	COG1119	ATPase activity
SynA18461_RS07035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA18461_RS07050	COG1121	(ABC) transporter
SynA18461_RS07055	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA18461_RS07060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynA18461_RS07065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynA18461_RS07160	COG0724	RNA recognition motif
SynA18461_RS07255	COG2197	response regulator
SynA18461_RS07270	COG0189	ligase activity
SynA18461_RS07270	COG4067	protein conserved in archaea
SynA18461_RS07275	COG2197	response regulator
SynA18461_RS07320	COG0405	Gamma-glutamyltransferase
SynA18461_RS07415	COG2124	cytochrome p450
SynA18461_RS07445	COG0010	Belongs to the arginase family
SynA18461_RS07450	COG0375	protein maturation
SynA18461_RS07465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA18461_RS07470	COG1116	anion transmembrane transporter activity
SynA18461_RS07475	COG4638	Rieske (2fe-2S)
SynA18461_RS07495	COG2144	transferase activity, transferring acyl groups
SynA18461_RS07520	COG2072	flavoprotein involved in K transport
SynA18461_RS07535	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SynA18461_RS07615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynA18461_RS07655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA18461_RS07775	COG0180	Tryptophanyl-tRNA synthetase
SynA18461_RS07790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynA18461_RS07800	COG0837	glucose binding
SynA18461_RS07805	COG0083	homoserine kinase activity
SynA18461_RS07810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_RS07815	COG0339	signal peptide processing
SynA18461_RS07830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynA18461_RS07870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynA18461_RS07875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynA18461_RS07885	COG3794	PFAM blue (type 1) copper domain protein
SynA18461_RS07915	COG0542	response to heat
SynA18461_RS07920	COG0720	synthase
SynA18461_RS07925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynA18461_RS07925	COG0140	phosphoribosyl-ATP diphosphatase activity
SynA18461_RS07945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_RS07980	COG2010	Cytochrome c
SynA18461_RS07995	COG0159	tryptophan synthase activity
SynA18461_RS08020	COG0418	dihydroorotase activity
SynA18461_RS08025	COG0659	secondary active sulfate transmembrane transporter activity
SynA18461_RS08030	COG0530	calcium, potassium:sodium antiporter activity
SynA18461_RS08050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynA18461_RS08055	COG1845	cytochrome c oxidase, subunit III
SynA18461_RS08070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA18461_RS08085	COG0037	tRNA processing
SynA18461_RS08090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynA18461_RS08095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA18461_RS08110	COG0456	acetyltransferase
SynA18461_RS08115	COG1132	(ABC) transporter
SynA18461_RS08120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynA18461_RS08125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynA18461_RS08130	COG3842	ATPase activity
SynA18461_RS08135	COG0251	oxidation-reduction process
SynA18461_RS08285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynA18461_RS08305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynA18461_RS08310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_RS08315	COG2135	peptidase activity
SynA18461_RS08320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_RS08330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA18461_RS08330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynA18461_RS08375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA18461_RS08380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynA18461_RS08385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynA18461_RS08395	COG0196	riboflavin kinase activity
SynA18461_RS08400	COG0352	thiamine-phosphate diphosphorylase activity
SynA18461_RS08420	COG1691	(AIR) carboxylase
SynA18461_RS08430	COG0336	Belongs to the RNA methyltransferase TrmD family
SynA18461_RS08445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynA18461_RS08455	COG0670	Belongs to the BI1 family
SynA18461_RS08460	COG1702	phosphate starvation-inducible protein PhoH
SynA18461_RS08465	COG0228	four-way junction DNA binding
SynA18461_RS08470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynA18461_RS08480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynA18461_RS08485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_RS08490	COG0482	sulfurtransferase activity
SynA18461_RS08495	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynA18461_RS08525	COG0134	indole-3-glycerol-phosphate synthase activity
SynA18461_RS08530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynA18461_RS08535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA18461_RS08550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynA18461_RS08555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA18461_RS08560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynA18461_RS08565	COG0285	dihydrofolate synthase activity
SynA18461_RS08595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA18461_RS08600	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynA18461_RS08615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynA18461_RS08625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynA18461_RS08630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynA18461_RS08635	COG4956	integral membrane protein (PIN domain superfamily)
SynA18461_RS08640	COG0740	serine-type endopeptidase activity
SynA18461_RS08645	COG0740	serine-type endopeptidase activity
SynA18461_RS08650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynA18461_RS08655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynA18461_RS08735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA18461_RS08790	COG0752	glycyl-tRNA synthetase alpha subunit
SynA18461_RS08805	COG2226	methyltransferase
SynA18461_RS08810	COG0107	imidazoleglycerol-phosphate synthase activity
SynA18461_RS08820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA18461_RS08825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynA18461_RS08830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynA18461_RS08830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynA18461_RS08835	COG3695	enzyme binding
SynA18461_RS08840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynA18461_RS08865	COG4970	Tfp pilus assembly protein FimT
SynA18461_RS08880	COG0745	RESPONSE REGULATOR receiver
SynA18461_RS08920	COG0481	GTPase activity
SynA18461_RS08930	COG0579	oxidoreductase
SynA18461_RS08935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynA18461_RS08955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynA18461_RS08975	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynA18461_RS08980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynA18461_RS08995	COG0556	nucleotide-excision repair
SynA18461_RS09045	COG3239	Fatty acid desaturase
SynA18461_RS09075	COG0424	maF-like protein
SynA18461_RS09085	COG1492	cobalamin metabolic process
SynA18461_RS09115	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_RS09120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA18461_RS09125	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA18461_RS09150	COG4451	ribulose bisphosphate carboxylase, small
SynA18461_RS09155	COG1850	ribulose-bisphosphate carboxylase activity
SynA18461_RS09160	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA18461_RS09165	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynA18461_RS09170	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynA18461_RS09180	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA18461_RS09185	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynA18461_RS09190	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynA18461_RS09215	COG0730	response to heat
SynA18461_RS09220	COG0095	Lipoate-protein ligase
SynA18461_RS09225	COG0517	IMP dehydrogenase activity
SynA18461_RS09225	COG1994	Peptidase M50
SynA18461_RS09230	COG0135	phosphoribosylanthranilate isomerase activity
SynA18461_RS09235	COG0302	gtp cyclohydrolase
SynA18461_RS09240	COG0300	oxidoreductase activity
SynA18461_RS09245	COG0825	malonyl-CoA metabolic process
SynA18461_RS09250	COG5322	oxidoreductase activity
SynA18461_RS09255	COG3396	Phenylacetate-CoA oxygenase
SynA18461_RS09265	COG0539	negative regulation of cytoplasmic translation
SynA18461_RS09275	COG1496	oxidoreductase activity
SynA18461_RS09280	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynA18461_RS09300	COG0028	Belongs to the TPP enzyme family
SynA18461_RS09305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA18461_RS09315	COG2226	methyltransferase
SynA18461_RS09330	COG0528	UMP kinase activity
SynA18461_RS09335	COG0233	cytoplasmic translational termination
SynA18461_RS09350	COG0415	Belongs to the DNA photolyase family
SynA18461_RS09360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynA18461_RS09365	COG0768	penicillin binding
SynA18461_RS09380	COG0588	phosphoglycerate mutase activity
SynA18461_RS09410	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA18461_RS09425	COG0442	prolyl-tRNA aminoacylation
SynA18461_RS09435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynA18461_RS09440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynA18461_RS09455	COG0629	single-stranded DNA binding
SynA18461_RS09470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynA18461_RS09480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynA18461_RS09485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_RS09495	COG0181	hydroxymethylbilane synthase activity
SynA18461_RS09510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynA18461_RS09515	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynA18461_RS09535	COG0432	Pfam Uncharacterised protein family UPF0047
SynA18461_RS09540	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynA18461_RS09545	COG0523	cobalamin synthesis protein
SynA18461_RS09555	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA18461_RS09580	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynA18461_RS09585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_RS09605	COG0708	Exodeoxyribonuclease III
SynA18461_RS09610	COG0277	FAD linked oxidase domain protein
SynA18461_RS09615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynA18461_RS09625	COG0295	cytidine deaminase activity
SynA18461_RS09635	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynA18461_RS09645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA18461_RS09650	COG1666	GTP binding
SynA18461_RS09665	COG0857	belongs to the CobB CobQ family
SynA18461_RS09675	COG3000	fatty acid hydroxylase
SynA18461_RS09675	COG0300	oxidoreductase activity
SynA18461_RS09680	COG0024	Methionine aminopeptidase
SynA18461_RS09690	COG0335	large ribosomal subunit rRNA binding
SynA18461_RS09710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynA18461_RS09730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynA18461_RS09740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA18461_RS09745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynA18461_RS09760	COG0194	GDP metabolic process
SynA18461_RS09765	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynA18461_RS09770	COG0805	protein transport
SynA18461_RS09780	COG0723	plastoquinol--plastocyanin reductase activity
SynA18461_RS09785	COG0739	heme binding
SynA18461_RS09790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynA18461_RS09795	COG2875	Belongs to the precorrin methyltransferase family
SynA18461_RS09810	COG0248	Ppx GppA phosphatase
SynA18461_RS09820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynA18461_RS09825	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynA18461_RS09830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynA18461_RS09845	COG1028	Short-chain dehydrogenase reductase Sdr
SynA18461_RS09855	COG0459	protein refolding
SynA18461_RS09860	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynA18461_RS09880	COG0109	protoheme IX farnesyltransferase activity
SynA18461_RS09885	COG1612	heme a metabolic process
SynA18461_RS09890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynA18461_RS09900	COG1845	cytochrome c oxidase, subunit III
SynA18461_RS09930	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynA18461_RS09945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynA18461_RS09950	COG1007	ATP synthesis coupled electron transport
SynA18461_RS09955	COG0577	efflux transmembrane transporter activity
SynA18461_RS09955	COG1136	(ABC) transporter
SynA18461_RS09970	COG0436	Aminotransferase
SynA18461_RS09975	COG3118	belongs to the thioredoxin family
SynA18461_RS09980	COG1842	Phage shock protein A
SynA18461_RS09990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynA18461_RS10000	COG0697	spore germination
SynA18461_RS10005	COG0616	signal peptide processing
SynA18461_RS10020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynA18461_RS10025	COG0594	ribonuclease P activity
SynA18461_RS10035	COG0706	membrane insertase activity
SynA18461_RS10045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynA18461_RS10055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynA18461_RS10060	COG0750	zinc metalloprotease
SynA18461_RS10065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynA18461_RS10070	COG1185	polyribonucleotide nucleotidyltransferase activity
SynA18461_RS10080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynA18461_RS10205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynA18461_RS10210	COG2226	methyltransferase
SynA18461_RS10220	COG4176	ABC-type proline glycine betaine transport system permease component
SynA18461_RS10225	COG2113	Glycine betaine
SynA18461_RS10250	COG2988	succinylglutamate desuccinylase activity
SynA18461_RS10255	COG0435	Glutathione S-transferase
SynA18461_RS10265	COG0488	(ABC) transporter
SynA18461_RS10280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynA18461_RS10295	COG1193	negative regulation of DNA recombination
SynA18461_RS10305	COG0113	porphobilinogen synthase activity
SynA18461_RS10310	COG0484	heat shock protein binding
SynA18461_RS10315	COG4243	Vitamin k epoxide reductase
SynA18461_RS10320	COG0659	secondary active sulfate transmembrane transporter activity
SynA18461_RS10330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynA18461_RS10365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynA18461_RS10390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynA18461_RS10395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynA18461_RS10405	COG1012	belongs to the aldehyde dehydrogenase family
SynA18461_RS10410	COG1388	LysM domain
SynA18461_RS10410	COG0741	lytic transglycosylase activity
SynA18461_RS10430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynA18461_RS10435	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynA18461_RS10440	COG0235	Class ii aldolase
SynA18461_RS10445	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynA18461_RS10480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA18461_RS10485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynA18461_RS10490	COG0793	Belongs to the peptidase S41A family
SynA18461_RS10495	COG1078	dGTPase activity
SynA18461_RS10500	COG0850	regulation of cytokinetic process
SynA18461_RS10505	COG2894	cell division
SynA18461_RS10510	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynA18461_RS10530	COG0009	L-threonylcarbamoyladenylate synthase
SynA18461_RS10535	COG2890	protein-(glutamine-N5) methyltransferase activity
SynA18461_RS10540	COG0758	DNA mediated transformation
SynA18461_RS10540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA18461_RS10575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynA18461_RS10580	COG0539	negative regulation of cytoplasmic translation
SynA18461_RS10585	COG0546	phosphoglycolate phosphatase activity
SynA18461_RS10590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynA18461_RS10595	COG1070	Carbohydrate kinase
SynA18461_RS10610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynA18461_RS10685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynA18461_RS10850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynA18461_RS10855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynA18461_RS10855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynA18461_RS10860	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynA18461_RS10865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynA18461_RS10875	COG4989	oxidoreductase activity
SynA18461_RS10905	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynA18461_RS10925	COG0408	coproporphyrinogen oxidase activity
SynA18461_RS10930	COG0489	protein tyrosine kinase activity
SynA18461_RS10935	COG0772	Belongs to the SEDS family
SynA18461_RS10950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynA18461_RS10960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynA18461_RS10975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynA18461_RS10980	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynA18461_RS10985	COG1606	tRNA processing
SynA18461_RS10990	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynA18461_RS11010	COG3001	Fructosamine kinase
SynA18461_RS11015	COG1233	COG1233 Phytoene dehydrogenase and related
SynA18461_RS11040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynA18461_RS11055	COG3854	ATPases associated with a variety of cellular activities
SynA18461_RS11070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynA18461_RS11075	COG0088	Forms part of the polypeptide exit tunnel
SynA18461_RS11080	COG0089	rRNA binding
SynA18461_RS11085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynA18461_RS11090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynA18461_RS11095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynA18461_RS11100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynA18461_RS11105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynA18461_RS11110	COG0255	Belongs to the universal ribosomal protein uL29 family
SynA18461_RS11115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynA18461_RS11120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynA18461_RS11125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynA18461_RS11130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynA18461_RS11135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynA18461_RS11140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynA18461_RS11145	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynA18461_RS11150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynA18461_RS11155	COG0200	Binds to the 23S rRNA
SynA18461_RS11160	COG0201	protein transport
SynA18461_RS11165	COG0563	adenylate kinase activity
SynA18461_RS11170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynA18461_RS11175	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynA18461_RS11180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynA18461_RS11185	COG0202	RNA polymerase activity
SynA18461_RS11190	COG0203	ribosomal protein L17
SynA18461_RS11195	COG0101	tRNA pseudouridine synthase activity
SynA18461_RS11200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynA18461_RS11205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynA18461_RS11210	COG0254	rRNA binding
SynA18461_RS11215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynA18461_RS11225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynA18461_RS11270	COG0463	Glycosyl transferase, family 2
SynA18461_RS11310	COG2885	chlorophyll binding
SynA18461_RS11315	COG2885	chlorophyll binding
SynA18461_RS11345	COG3659	wide pore channel activity
SynA18461_RS11355	COG3128	pkhd-type hydroxylase
SynA18461_RS11360	COG1840	ABC-type Fe3 transport system, periplasmic component
SynA18461_RS11380	COG3659	wide pore channel activity
SynA18461_RS11400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynA18461_RS11410	COG0070	glutamate synthase
SynA18461_RS11410	COG0069	glutamate synthase activity
SynA18461_RS11410	COG0067	glutamate synthase
SynA18461_RS11425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynA18461_RS11430	COG0049	tRNA binding
SynA18461_RS11435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynA18461_RS11440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynA18461_RS11445	COG0051	transcription antitermination factor activity, RNA binding
SynA18461_RS11450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynA18461_RS11455	COG2226	methyltransferase
SynA18461_RS11470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynA18461_RS11475	COG1530	ribonuclease E activity
SynA18461_RS11485	COG0436	Aminotransferase
SynA18461_RS11490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynA18461_RS11520	COG0033	Phosphoglucomutase
SynA18461_RS11530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynA18461_RS11540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynA18461_RS11560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynA18461_RS11565	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynA18461_RS11570	COG0175	sulfate reduction
SynA18461_RS11575	COG1252	NADH dehydrogenase
SynA18461_RS11580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynA18461_RS11585	COG3273	potassium ion transport
SynA18461_RS11585	COG0471	metal ion transport
SynA18461_RS11590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynA18461_RS11595	COG0569	domain protein
SynA18461_RS11600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynA18461_RS11625	COG0488	(ABC) transporter
SynA18461_RS11635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynA18461_RS11650	COG1643	Atp-dependent helicase
SynA18461_RS11655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynA18461_RS11665	COG1570	exodeoxyribonuclease VII activity
SynA18461_RS11670	COG1722	exodeoxyribonuclease VII activity
SynA18461_RS11730	COG1968	undecaprenyl-diphosphatase activity
SynA18461_RS11740	COG1555	photosystem II stabilization
SynA18461_RS11745	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynA18461_RS11750	COG4243	Vitamin k epoxide reductase
SynA18461_RS11755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynA18461_RS11770	COG1032	radical SAM domain protein
SynA18461_RS11800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynA18461_RS11825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynA18461_RS11830	COG1472	Belongs to the glycosyl hydrolase 3 family
SynA18461_RS11835	COG0457	Tetratricopeptide repeat
SynA18461_RS11835	COG0463	Glycosyl transferase, family 2
SynA18461_RS11840	COG1587	Uroporphyrinogen-III synthase
SynA18461_RS11855	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA18461_RS11860	COG0316	Belongs to the HesB IscA family
SynA18461_RS11880	COG1090	epimerase
SynA18461_RS11900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynA18461_RS11905	COG3659	wide pore channel activity
SynA18461_RS11910	COG3659	wide pore channel activity
SynA18461_RS11920	COG3659	wide pore channel activity
SynA18461_RS11960	COG1122	ATPase activity
SynA18461_RS11970	COG0745	RESPONSE REGULATOR receiver
SynA18461_RS11980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynA18461_RS11985	COG2217	Heavy metal translocating P-type atpase
SynA18461_RS11990	COG3063	Type IV pilus biogenesis stability protein PilW
SynA18461_RS11995	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynA18461_RS12005	COG0416	fatty acid biosynthetic process
SynA18461_RS12010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynA18461_RS12015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynA18461_RS12030	COG1214	PFAM Peptidase M22, glycoprotease
SynA18461_RS12040	COG0617	tRNA 3'-terminal CCA addition
SynA18461_RS12050	COG1562	ergosterol biosynthetic process
SynA18461_RS12055	COG0493	'glutamate synthase
SynA18461_RS12055	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynA18461_RS12070	COG0583	DNA-binding transcription factor activity
SynA18461_RS12080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynA18461_RS12085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_RS12100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynA18461_RS12110	COG2197	response regulator
SynA18461_RS12120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynA18461_RS12125	COG0713	ATP synthesis coupled electron transport
SynA18461_RS12130	COG0839	Belongs to the complex I subunit 6 family
SynA18461_RS12135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynA18461_RS12140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynA18461_RS12145	COG0372	Belongs to the citrate synthase family
SynA18461_RS12150	COG2062	phosphohistidine phosphatase, SixA
SynA18461_RS12165	COG1420	regulation of RNA biosynthetic process
SynA18461_RS12170	COG0133	tryptophan synthase activity
SynA18461_RS12175	COG0023	Translation Initiation Factor
SynA18461_RS12180	COG0529	Catalyzes the synthesis of activated sulfate
SynA18461_RS12185	COG0628	permease
SynA18461_RS12190	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynA18461_RS12195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SynA18461_RS12200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynA18461_RS12205	COG0564	pseudouridine synthase activity
SynA18461_RS12210	COG0745	RESPONSE REGULATOR receiver
SynA18461_RS12220	COG1104	cysteine desulfurase activity
SynA18461_RS12250	COG0275	rRNA processing
SynA18461_RS12255	COG0649	NAD binding
SynA18461_RS12265	COG0824	Thioesterase
SynA18461_RS12290	COG1575	Belongs to the MenA family. Type 1 subfamily
SynA18461_RS12300	COG0189	ligase activity
SynA18461_RS12305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynA18461_RS12320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynA18461_RS12325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynA18461_RS12330	COG0512	Glutamine amidotransferase of anthranilate synthase
SynA18461_RS12340	COG0252	asparaginase activity
SynA18461_RS12345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA18461_RS12350	COG0018	arginyl-trna synthetase
SynA18461_RS12355	COG0157	Belongs to the NadC ModD family
SynA18461_RS12370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynA18461_RS12380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynA18461_RS12385	COG4172	Belongs to the ABC transporter superfamily
SynA18461_RS12390	COG0564	pseudouridine synthase activity
SynA18461_RS12400	COG0589	response to stress
SynA18461_RS12405	COG0126	phosphoglycerate kinase activity
SynA18461_RS12425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynA18461_RS12430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynA18461_RS12460	COG0167	dihydroorotate dehydrogenase activity
SynA18461_RS12465	COG0328	RNA-DNA hybrid ribonuclease activity
SynA18461_RS12475	COG0222	ribosome binding
SynA18461_RS12480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynA18461_RS12485	COG0081	regulation of translation
SynA18461_RS12490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynA18461_RS12495	COG0250	Participates in transcription elongation, termination and antitermination
SynA18461_RS12500	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynA18461_RS12505	COG0542	response to heat
SynA18461_RS12510	COG0346	lactoylglutathione lyase activity
SynA18461_RS12515	COG0148	phosphopyruvate hydratase activity
SynA18461_RS12520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA18461_RS12540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynA18461_RS12545	COG0237	dephospho-CoA kinase activity
SynA18461_RS12555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynA18461_RS12560	COG2022	thiamine diphosphate biosynthetic process
SynA18461_RS12560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynA18461_RS12580	COG0105	UTP biosynthetic process
SynA18461_RS12590	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SynA18461_RS12605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynA18461_RS12620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynA18461_RS12630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynA18461_RS12660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA18461_RS12660	COG0426	domain, Protein
SynA18461_RS12665	COG0426	domain, Protein
SynA18461_RS12665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynA18461_RS12675	COG1733	regulation of RNA biosynthetic process
SynA18461_RS12685	COG1741	Belongs to the pirin family
SynA18461_RS12700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA18461_RS12700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynA18461_RS12705	COG0509	glycine decarboxylation via glycine cleavage system
SynA18461_RS12710	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynA18461_RS12720	COG0359	binds to the 23S rRNA
SynA18461_RS12725	COG0305	Participates in initiation and elongation during chromosome replication
SynA18461_RS12725	COG1372	Participates in initiation and elongation during chromosome replication
SynA18461_RS12725	COG1372	Participates in initiation and elongation during chromosome replication
SynA18461_RS12725	COG0305	Participates in initiation and elongation during chromosome replication
SynA18461_RS12740	COG0445	tRNA wobble uridine modification
SynA18461_RS12775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynA18461_RS12795	COG0398	Pfam SNARE associated Golgi protein
SynA18461_RS12815	COG0525	valine-tRNA ligase activity
SynA18461_RS12835	COG4221	oxidoreductase activity
SynA18461_RS12995	COG3956	TIGRFAM MazG family protein
SynA18461_RS13005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynA18461_RS13010	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynA18461_RS13015	COG0010	Belongs to the arginase family
SynA18461_RS13025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynA18461_RS13030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynA18461_RS13040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_RS13045	COG0504	CTP synthase activity
SynA18461_RS13050	COG0602	queuosine metabolic process
SynA18461_RS13055	COG2084	Dehydrogenase
SynA18461_RS13060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynA18461_RS13080	COG0366	Alpha amylase catalytic
SynA18461_RS13085	COG0463	Glycosyl transferase, family 2
SynA18461_RS13125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynA18461_RS13130	COG0830	nickel cation binding
SynA18461_RS13135	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynA18461_RS13140	COG0829	nickel cation binding
SynA18461_RS13145	COG0831	urea catabolic process
SynA18461_RS13150	COG0832	Belongs to the urease beta subunit family
SynA18461_RS13155	COG0804	urea catabolic process
SynA18461_RS13175	COG0367	asparagine synthase
SynA18461_RS13180	COG0540	Belongs to the ATCase OTCase family
SynA18461_RS13195	COG2308	Evidence 4 Homologs of previously reported genes of
SynA18461_RS13215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynA18461_RS13220	COG0746	molybdenum cofactor guanylyltransferase activity
SynA18461_RS13225	COG2223	nitrite transmembrane transporter activity
SynA18461_RS13230	COG0243	molybdopterin cofactor binding
SynA18461_RS13250	COG0315	cyclic pyranopterin monophosphate synthase activity
SynA18461_RS13255	COG0303	'Molybdopterin
SynA18461_RS13270	COG0314	molybdopterin synthase activity
SynA18461_RS13280	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynA18461_RS13285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynA18461_RS13295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynA18461_RS13305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynA18461_RS13310	COG1121	(ABC) transporter
SynA18461_RS13315	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynA18461_RS13320	COG0523	cobalamin synthesis protein
SynA18461_RS13335	COG1116	anion transmembrane transporter activity
SynA18461_RS13340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynA18461_RS13345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SynA18461_RS13345	COG1116	anion transmembrane transporter activity
SynA18461_RS13350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynA18461_RS13360	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynA18461_RS13370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynA18461_RS13385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynA18461_RS13390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynA18461_RS13395	COG0170	dolichyl monophosphate biosynthetic process
SynA18461_RS13405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynA18461_RS13410	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynA18461_RS13415	COG0038	chloride channel
SynA18461_RS13430	COG0788	formyltetrahydrofolate deformylase activity
SynA18461_RS13445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynA18461_RS13450	COG0443	Heat shock 70 kDa protein
SynA18461_RS13455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynA18461_RS13465	COG0360	Binds together with S18 to 16S ribosomal RNA
SynA18461_RS13475	COG0137	argininosuccinate synthase activity
SynA18461_RS13490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynA18461_RS13505	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynA18461_RS13510	COG0438	transferase activity, transferring glycosyl groups
SynA18461_RS13520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynA18461_RS13525	COG0497	DNA recombination
SynA18461_RS13530	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynA18461_RS13540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine