locus-tag	class	description
SynBMKMC1_RS00005	COG0592	DNA-directed DNA polymerase activity
SynBMKMC1_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynBMKMC1_RS00020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynBMKMC1_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynBMKMC1_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynBMKMC1_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynBMKMC1_RS00055	COG0552	protein localization to endoplasmic reticulum
SynBMKMC1_RS00060	COG2208	phosphoserine phosphatase activity
SynBMKMC1_RS00065	COG0165	Argininosuccinate lyase
SynBMKMC1_RS00070	COG0724	RNA recognition motif
SynBMKMC1_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynBMKMC1_RS00085	COG2081	HI0933 family
SynBMKMC1_RS00090	COG1459	type II secretion system
SynBMKMC1_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynBMKMC1_RS00105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynBMKMC1_RS00110	COG0484	heat shock protein binding
SynBMKMC1_RS00120	COG1162	GTPase activity
SynBMKMC1_RS00125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynBMKMC1_RS00130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynBMKMC1_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynBMKMC1_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynBMKMC1_RS00145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynBMKMC1_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynBMKMC1_RS00155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynBMKMC1_RS00160	COG0511	ligase activity, forming carbon-carbon bonds
SynBMKMC1_RS00165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynBMKMC1_RS00235	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynBMKMC1_RS00240	COG0519	Catalyzes the synthesis of GMP from XMP
SynBMKMC1_RS00240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynBMKMC1_RS00255	COG0768	penicillin binding
SynBMKMC1_RS00260	COG0438	transferase activity, transferring glycosyl groups
SynBMKMC1_RS00265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynBMKMC1_RS00275	COG2022	thiamine diphosphate biosynthetic process
SynBMKMC1_RS00290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynBMKMC1_RS00295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynBMKMC1_RS00300	COG2385	sporulation resulting in formation of a cellular spore
SynBMKMC1_RS00305	COG1215	transferase activity, transferring glycosyl groups
SynBMKMC1_RS00310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynBMKMC1_RS00320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynBMKMC1_RS00325	COG0740	serine-type endopeptidase activity
SynBMKMC1_RS00330	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynBMKMC1_RS00335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynBMKMC1_RS00340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynBMKMC1_RS00345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynBMKMC1_RS00355	COG0037	tRNA processing
SynBMKMC1_RS00390	COG2801	Transposase and inactivated derivatives
SynBMKMC1_RS00445	COG0556	nucleotide-excision repair
SynBMKMC1_RS00460	COG2082	Precorrin-8x methylmutase
SynBMKMC1_RS00465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynBMKMC1_RS00475	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynBMKMC1_RS00490	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SynBMKMC1_RS00500	COG1091	dTDP-4-dehydrorhamnose reductase activity
SynBMKMC1_RS00505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynBMKMC1_RS00530	COG0653	protein targeting
SynBMKMC1_RS00535	COG0438	transferase activity, transferring glycosyl groups
SynBMKMC1_RS00535	COG1216	Glycosyl transferase, family 2
SynBMKMC1_RS00595	COG1045	serine acetyltransferase
SynBMKMC1_RS00600	COG1725	Transcriptional regulator
SynBMKMC1_RS00610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynBMKMC1_RS00615	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynBMKMC1_RS00620	COG1372	Participates in initiation and elongation during chromosome replication
SynBMKMC1_RS00620	COG0187	DNA topoisomerase II activity
SynBMKMC1_RS00630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynBMKMC1_RS00635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynBMKMC1_RS00640	COG0386	Belongs to the glutathione peroxidase family
SynBMKMC1_RS00645	COG2239	Acts as a magnesium transporter
SynBMKMC1_RS00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynBMKMC1_RS00680	COG0477	Major facilitator Superfamily
SynBMKMC1_RS00715	COG1070	Carbohydrate kinase
SynBMKMC1_RS00725	COG0802	atpase or kinase
SynBMKMC1_RS00730	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynBMKMC1_RS00735	COG0586	Pfam SNARE associated Golgi protein
SynBMKMC1_RS00740	COG0629	single-stranded DNA binding
SynBMKMC1_RS00765	COG0745	RESPONSE REGULATOR receiver
SynBMKMC1_RS00770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynBMKMC1_RS00790	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynBMKMC1_RS00795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynBMKMC1_RS00800	COG1357	PFAM Pentapeptide repeats (8 copies)
SynBMKMC1_RS00800	COG0515	serine threonine protein kinase
SynBMKMC1_RS00805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynBMKMC1_RS00810	COG2255	four-way junction helicase activity
SynBMKMC1_RS00820	COG1473	amidohydrolase
SynBMKMC1_RS00835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynBMKMC1_RS00845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynBMKMC1_RS00850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynBMKMC1_RS00855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynBMKMC1_RS00860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynBMKMC1_RS00865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynBMKMC1_RS00870	COG0662	Cupin 2, conserved barrel domain protein
SynBMKMC1_RS00870	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynBMKMC1_RS00875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynBMKMC1_RS00885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynBMKMC1_RS00900	COG0571	ribonuclease III activity
SynBMKMC1_RS00925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynBMKMC1_RS00930	COG0058	SHG alpha-glucan phosphorylase activity
SynBMKMC1_RS00935	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SynBMKMC1_RS00940	COG0475	glutathione-regulated potassium exporter activity
SynBMKMC1_RS00960	COG0277	FAD linked oxidase domain protein
SynBMKMC1_RS00970	COG0247	lactate metabolic process
SynBMKMC1_RS00980	COG0538	isocitrate dehydrogenase activity
SynBMKMC1_RS00985	COG0463	Glycosyl transferase, family 2
SynBMKMC1_RS01000	COG5398	heme oxygenase
SynBMKMC1_RS01015	COG0438	transferase activity, transferring glycosyl groups
SynBMKMC1_RS01025	COG0438	transferase activity, transferring glycosyl groups
SynBMKMC1_RS01030	COG0438	transferase activity, transferring glycosyl groups
SynBMKMC1_RS01050	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynBMKMC1_RS01060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynBMKMC1_RS01065	COG0517	IMP dehydrogenase activity
SynBMKMC1_RS01065	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynBMKMC1_RS01065	COG0617	tRNA 3'-terminal CCA addition
SynBMKMC1_RS01080	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynBMKMC1_RS01100	COG0709	Synthesizes selenophosphate from selenide and ATP
SynBMKMC1_RS01105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynBMKMC1_RS01115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynBMKMC1_RS01150	COG0438	transferase activity, transferring glycosyl groups
SynBMKMC1_RS01205	COG0438	transferase activity, transferring glycosyl groups
SynBMKMC1_RS01225	COG0489	protein tyrosine kinase activity
SynBMKMC1_RS01305	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynBMKMC1_RS01310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynBMKMC1_RS01345	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynBMKMC1_RS01350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynBMKMC1_RS01360	COG3039	Transposase
SynBMKMC1_RS01365	COG1132	(ABC) transporter
SynBMKMC1_RS01370	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynBMKMC1_RS01390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynBMKMC1_RS01425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynBMKMC1_RS01455	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynBMKMC1_RS01460	COG0367	asparagine synthase
SynBMKMC1_RS01470	COG3039	Transposase
SynBMKMC1_RS01480	COG0438	transferase activity, transferring glycosyl groups
SynBMKMC1_RS01495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynBMKMC1_RS01525	COG0297	glycogen (starch) synthase activity
SynBMKMC1_RS01535	COG0494	nUDIX hydrolase
SynBMKMC1_RS01600	COG0124	histidyl-tRNA synthetase
SynBMKMC1_RS01605	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynBMKMC1_RS01640	COG4447	cellulose binding
SynBMKMC1_RS01645	COG1773	rubredoxin
SynBMKMC1_RS01650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynBMKMC1_RS01655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynBMKMC1_RS01660	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynBMKMC1_RS01665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynBMKMC1_RS01680	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynBMKMC1_RS01680	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynBMKMC1_RS01690	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SynBMKMC1_RS01695	COG0494	nUDIX hydrolase
SynBMKMC1_RS01700	COG0415	Belongs to the DNA photolyase family
SynBMKMC1_RS01705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SynBMKMC1_RS01730	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynBMKMC1_RS01735	COG0131	Imidazoleglycerol-phosphate dehydratase
SynBMKMC1_RS01740	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynBMKMC1_RS01755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynBMKMC1_RS01775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynBMKMC1_RS01780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynBMKMC1_RS01795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynBMKMC1_RS01810	COG1253	flavin adenine dinucleotide binding
SynBMKMC1_RS01815	COG0673	inositol 2-dehydrogenase activity
SynBMKMC1_RS01835	COG0343	queuine tRNA-ribosyltransferase activity
SynBMKMC1_RS01840	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynBMKMC1_RS01860	COG0138	bifunctional purine biosynthesis protein purh
SynBMKMC1_RS01875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynBMKMC1_RS01880	COG0004	ammonium transporteR
SynBMKMC1_RS01885	COG1489	DNA binding
SynBMKMC1_RS01890	COG0728	peptidoglycan biosynthetic process
SynBMKMC1_RS01915	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynBMKMC1_RS01920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynBMKMC1_RS01925	COG1546	Belongs to the CinA family
SynBMKMC1_RS01925	COG1058	Belongs to the CinA family
SynBMKMC1_RS01930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynBMKMC1_RS01935	COG0066	3-isopropylmalate dehydratase activity
SynBMKMC1_RS01970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynBMKMC1_RS01975	COG0193	aminoacyl-tRNA hydrolase activity
SynBMKMC1_RS01990	COG4372	Transposase
SynBMKMC1_RS01995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynBMKMC1_RS02000	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynBMKMC1_RS02010	COG0717	Belongs to the dCTP deaminase family
SynBMKMC1_RS02020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynBMKMC1_RS02030	COG0741	lytic transglycosylase activity
SynBMKMC1_RS02040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynBMKMC1_RS02055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynBMKMC1_RS02075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynBMKMC1_RS02095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynBMKMC1_RS02110	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynBMKMC1_RS02115	COG2094	Belongs to the DNA glycosylase MPG family
SynBMKMC1_RS02120	COG0540	Belongs to the ATCase OTCase family
SynBMKMC1_RS02145	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynBMKMC1_RS02160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynBMKMC1_RS02175	COG2046	Belongs to the sulfate adenylyltransferase family
SynBMKMC1_RS02175	COG0529	Catalyzes the synthesis of activated sulfate
SynBMKMC1_RS02180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynBMKMC1_RS02185	COG0800	Aldolase
SynBMKMC1_RS02195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynBMKMC1_RS02200	COG0737	Belongs to the 5'-nucleotidase family
SynBMKMC1_RS02210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynBMKMC1_RS02215	COG2226	methyltransferase
SynBMKMC1_RS02220	COG4175	Glycine betaine
SynBMKMC1_RS02225	COG4176	ABC-type proline glycine betaine transport system permease component
SynBMKMC1_RS02230	COG2113	Glycine betaine
SynBMKMC1_RS02235	COG0385	Bile acid
SynBMKMC1_RS02245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynBMKMC1_RS02255	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynBMKMC1_RS02260	COG0436	Aminotransferase
SynBMKMC1_RS02270	COG1530	ribonuclease E activity
SynBMKMC1_RS02275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynBMKMC1_RS02290	COG2226	methyltransferase
SynBMKMC1_RS02295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynBMKMC1_RS02300	COG0051	transcription antitermination factor activity, RNA binding
SynBMKMC1_RS02305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynBMKMC1_RS02310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynBMKMC1_RS02315	COG0049	tRNA binding
SynBMKMC1_RS02320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynBMKMC1_RS02335	COG0067	glutamate synthase
SynBMKMC1_RS02335	COG0069	glutamate synthase activity
SynBMKMC1_RS02335	COG0070	glutamate synthase
SynBMKMC1_RS02365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynBMKMC1_RS02385	COG2885	chlorophyll binding
SynBMKMC1_RS02390	COG2885	chlorophyll binding
SynBMKMC1_RS02425	COG0463	Glycosyl transferase, family 2
SynBMKMC1_RS02450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynBMKMC1_RS02460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynBMKMC1_RS02465	COG0254	rRNA binding
SynBMKMC1_RS02470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynBMKMC1_RS02475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynBMKMC1_RS02480	COG0101	tRNA pseudouridine synthase activity
SynBMKMC1_RS02485	COG0203	ribosomal protein L17
SynBMKMC1_RS02490	COG0202	RNA polymerase activity
SynBMKMC1_RS02495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynBMKMC1_RS02500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynBMKMC1_RS02505	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynBMKMC1_RS02510	COG0563	adenylate kinase activity
SynBMKMC1_RS02515	COG0201	protein transport
SynBMKMC1_RS02520	COG0200	Binds to the 23S rRNA
SynBMKMC1_RS02525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynBMKMC1_RS02530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynBMKMC1_RS02535	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynBMKMC1_RS02540	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynBMKMC1_RS02545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynBMKMC1_RS02550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynBMKMC1_RS02555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynBMKMC1_RS02560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynBMKMC1_RS02565	COG0255	Belongs to the universal ribosomal protein uL29 family
SynBMKMC1_RS02570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynBMKMC1_RS02575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynBMKMC1_RS02580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynBMKMC1_RS02585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynBMKMC1_RS02590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynBMKMC1_RS02595	COG0089	rRNA binding
SynBMKMC1_RS02600	COG0088	Forms part of the polypeptide exit tunnel
SynBMKMC1_RS02605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynBMKMC1_RS02620	COG3854	ATPases associated with a variety of cellular activities
SynBMKMC1_RS02635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynBMKMC1_RS02655	COG0287	Prephenate dehydrogenase
SynBMKMC1_RS02665	COG3001	Fructosamine kinase
SynBMKMC1_RS02685	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynBMKMC1_RS02690	COG1606	tRNA processing
SynBMKMC1_RS02695	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynBMKMC1_RS02700	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynBMKMC1_RS02715	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynBMKMC1_RS02720	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynBMKMC1_RS02725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynBMKMC1_RS02740	COG0772	Belongs to the SEDS family
SynBMKMC1_RS02745	COG0489	protein tyrosine kinase activity
SynBMKMC1_RS02750	COG0408	coproporphyrinogen oxidase activity
SynBMKMC1_RS02800	COG0667	Aldo Keto reductase
SynBMKMC1_RS02810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynBMKMC1_RS02815	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynBMKMC1_RS02820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynBMKMC1_RS02820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynBMKMC1_RS02825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynBMKMC1_RS02830	COG1413	lyase activity
SynBMKMC1_RS02915	COG0237	dephospho-CoA kinase activity
SynBMKMC1_RS02935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynBMKMC1_RS02975	COG1070	Carbohydrate kinase
SynBMKMC1_RS02980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynBMKMC1_RS02985	COG0546	phosphoglycolate phosphatase activity
SynBMKMC1_RS02990	COG0539	negative regulation of cytoplasmic translation
SynBMKMC1_RS03020	COG0589	response to stress
SynBMKMC1_RS03035	COG2890	protein-(glutamine-N5) methyltransferase activity
SynBMKMC1_RS03040	COG0009	L-threonylcarbamoyladenylate synthase
SynBMKMC1_RS03060	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynBMKMC1_RS03065	COG2894	cell division
SynBMKMC1_RS03070	COG0850	regulation of cytokinetic process
SynBMKMC1_RS03075	COG1078	dGTPase activity
SynBMKMC1_RS03080	COG0793	Belongs to the peptidase S41A family
SynBMKMC1_RS03085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynBMKMC1_RS03090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynBMKMC1_RS03095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SynBMKMC1_RS03130	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynBMKMC1_RS03135	COG0235	Class ii aldolase
SynBMKMC1_RS03140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynBMKMC1_RS03155	COG0514	ATP-dependent DNA helicase (RecQ)
SynBMKMC1_RS03160	COG1388	LysM domain
SynBMKMC1_RS03160	COG1705	Flagellar rod assembly protein muramidase FlgJ
SynBMKMC1_RS03165	COG1012	belongs to the aldehyde dehydrogenase family
SynBMKMC1_RS03175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynBMKMC1_RS03180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynBMKMC1_RS03200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynBMKMC1_RS03220	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynBMKMC1_RS03240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynBMKMC1_RS03255	COG1376	ErfK ybiS ycfS ynhG family protein
SynBMKMC1_RS03260	COG1160	GTP binding
SynBMKMC1_RS03265	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynBMKMC1_RS03275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynBMKMC1_RS03280	COG1799	cell septum assembly
SynBMKMC1_RS03285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynBMKMC1_RS03290	COG0438	transferase activity, transferring glycosyl groups
SynBMKMC1_RS03300	COG1381	Involved in DNA repair and RecF pathway recombination
SynBMKMC1_RS03305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynBMKMC1_RS03310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynBMKMC1_RS03315	COG0321	lipoyl(octanoyl) transferase activity
SynBMKMC1_RS03320	COG1022	Amp-dependent synthetase and ligase
SynBMKMC1_RS03335	COG0531	amino acid
SynBMKMC1_RS03340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynBMKMC1_RS03350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynBMKMC1_RS03370	COG3239	Fatty acid desaturase
SynBMKMC1_RS03380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynBMKMC1_RS03395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynBMKMC1_RS03405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynBMKMC1_RS03415	COG1104	cysteine desulfurase activity
SynBMKMC1_RS03440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynBMKMC1_RS03445	COG0579	oxidoreductase
SynBMKMC1_RS03460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynBMKMC1_RS03475	COG2095	MarC family integral membrane protein
SynBMKMC1_RS03480	COG0181	hydroxymethylbilane synthase activity
SynBMKMC1_RS03490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynBMKMC1_RS03495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynBMKMC1_RS03505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynBMKMC1_RS03520	COG0629	single-stranded DNA binding
SynBMKMC1_RS03530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynBMKMC1_RS03535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynBMKMC1_RS03545	COG0442	prolyl-tRNA aminoacylation
SynBMKMC1_RS03555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynBMKMC1_RS03575	COG0681	Belongs to the peptidase S26 family
SynBMKMC1_RS03580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SynBMKMC1_RS03600	COG0768	penicillin binding
SynBMKMC1_RS03605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynBMKMC1_RS03615	COG0415	Belongs to the DNA photolyase family
SynBMKMC1_RS03625	COG0233	cytoplasmic translational termination
SynBMKMC1_RS03630	COG0528	UMP kinase activity
SynBMKMC1_RS03645	COG2226	methyltransferase
SynBMKMC1_RS03655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynBMKMC1_RS03660	COG0028	Belongs to the TPP enzyme family
SynBMKMC1_RS03680	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynBMKMC1_RS03695	COG0539	negative regulation of cytoplasmic translation
SynBMKMC1_RS03705	COG3396	Phenylacetate-CoA oxygenase
SynBMKMC1_RS03710	COG5322	oxidoreductase activity
SynBMKMC1_RS03715	COG0825	malonyl-CoA metabolic process
SynBMKMC1_RS03720	COG4221	oxidoreductase activity
SynBMKMC1_RS03725	COG0302	gtp cyclohydrolase
SynBMKMC1_RS03735	COG0135	phosphoribosylanthranilate isomerase activity
SynBMKMC1_RS03740	COG1994	Peptidase M50
SynBMKMC1_RS03740	COG0517	IMP dehydrogenase activity
SynBMKMC1_RS03745	COG0095	Lipoate-protein ligase
SynBMKMC1_RS03750	COG0730	response to heat
SynBMKMC1_RS03785	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynBMKMC1_RS03790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynBMKMC1_RS03795	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynBMKMC1_RS03810	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynBMKMC1_RS03815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynBMKMC1_RS03820	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynBMKMC1_RS03825	COG1850	ribulose-bisphosphate carboxylase activity
SynBMKMC1_RS03830	COG4451	ribulose bisphosphate carboxylase, small
SynBMKMC1_RS03855	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynBMKMC1_RS03860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynBMKMC1_RS03865	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynBMKMC1_RS03895	COG0251	oxidation-reduction process
SynBMKMC1_RS03900	COG3842	ATPase activity
SynBMKMC1_RS03905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynBMKMC1_RS03910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynBMKMC1_RS03915	COG1132	(ABC) transporter
SynBMKMC1_RS03925	COG0456	acetyltransferase
SynBMKMC1_RS03940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynBMKMC1_RS03945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynBMKMC1_RS03965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynBMKMC1_RS03970	COG0811	peptide transport
SynBMKMC1_RS04000	COG1845	cytochrome c oxidase, subunit III
SynBMKMC1_RS04005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynBMKMC1_RS04010	COG2010	Cytochrome c
SynBMKMC1_RS04010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynBMKMC1_RS04030	COG0659	secondary active sulfate transmembrane transporter activity
SynBMKMC1_RS04035	COG0418	dihydroorotase activity
SynBMKMC1_RS04075	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynBMKMC1_RS04075	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynBMKMC1_RS04100	COG0159	tryptophan synthase activity
SynBMKMC1_RS04115	COG2010	Cytochrome c
SynBMKMC1_RS04145	COG3339	Conserved Protein
SynBMKMC1_RS04150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynBMKMC1_RS04165	COG1376	ErfK ybiS ycfS ynhG family protein
SynBMKMC1_RS04170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynBMKMC1_RS04170	COG0140	phosphoribosyl-ATP diphosphatase activity
SynBMKMC1_RS04180	COG0542	response to heat
SynBMKMC1_RS04200	COG3794	PFAM blue (type 1) copper domain protein
SynBMKMC1_RS04210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynBMKMC1_RS04215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynBMKMC1_RS04255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynBMKMC1_RS04290	COG0339	signal peptide processing
SynBMKMC1_RS04295	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynBMKMC1_RS04300	COG0083	homoserine kinase activity
SynBMKMC1_RS04305	COG0837	glucose binding
SynBMKMC1_RS04315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynBMKMC1_RS04335	COG0180	Tryptophanyl-tRNA synthetase
SynBMKMC1_RS04375	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynBMKMC1_RS04380	COG0154	amidase activity
SynBMKMC1_RS04405	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynBMKMC1_RS04410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynBMKMC1_RS04440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynBMKMC1_RS04450	COG2226	methyltransferase
SynBMKMC1_RS04480	COG3781	membrane
SynBMKMC1_RS04500	COG1064	alcohol dehydrogenase
SynBMKMC1_RS04535	COG2084	Dehydrogenase
SynBMKMC1_RS04705	COG0484	heat shock protein binding
SynBMKMC1_RS04745	COG0405	Gamma-glutamyltransferase
SynBMKMC1_RS04760	COG3961	Belongs to the TPP enzyme family
SynBMKMC1_RS04765	COG1454	alcohol dehydrogenase
SynBMKMC1_RS04785	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SynBMKMC1_RS04790	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SynBMKMC1_RS04795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynBMKMC1_RS04815	COG0668	transmembrane transport
SynBMKMC1_RS04860	COG4221	oxidoreductase activity
SynBMKMC1_RS04900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SynBMKMC1_RS04915	COG3657	addiction module killer protein
SynBMKMC1_RS04920	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynBMKMC1_RS04930	COG2337	Toxic component of a toxin-antitoxin (TA) module
SynBMKMC1_RS04955	COG3153	acetyltransferase
SynBMKMC1_RS05030	COG0671	phosphoesterase, PA-phosphatase related
SynBMKMC1_RS05055	COG2361	Protein of unknown function DUF86
SynBMKMC1_RS05130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynBMKMC1_RS05165	COG1598	PFAM Uncharacterised protein family UPF0150
SynBMKMC1_RS05185	COG0537	adenosine 5'-monophosphoramidase activity
SynBMKMC1_RS05215	COG0189	ligase activity
SynBMKMC1_RS05215	COG4067	protein conserved in archaea
SynBMKMC1_RS05285	COG2124	cytochrome p450
SynBMKMC1_RS05305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SynBMKMC1_RS05320	COG0459	protein refolding
SynBMKMC1_RS05395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynBMKMC1_RS05465	COG0300	oxidoreductase activity
SynBMKMC1_RS05570	COG0651	ATP synthesis coupled electron transport
SynBMKMC1_RS05575	COG1006	Multisubunit Na H antiporter MnhC subunit
SynBMKMC1_RS05610	COG1121	(ABC) transporter
SynBMKMC1_RS05615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynBMKMC1_RS05630	COG2010	Cytochrome c
SynBMKMC1_RS05635	COG0701	Predicted permease
SynBMKMC1_RS05650	COG1121	(ABC) transporter
SynBMKMC1_RS05655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynBMKMC1_RS05670	COG3659	wide pore channel activity
SynBMKMC1_RS05785	COG0523	cobalamin synthesis protein
SynBMKMC1_RS05845	COG2132	Multicopper oxidase
SynBMKMC1_RS05860	COG5002	protein histidine kinase activity
SynBMKMC1_RS05910	COG0681	Belongs to the peptidase S26 family
SynBMKMC1_RS05915	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynBMKMC1_RS05925	COG1376	ErfK ybiS ycfS ynhG family protein
SynBMKMC1_RS05930	COG0297	glycogen (starch) synthase activity
SynBMKMC1_RS05940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynBMKMC1_RS05950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynBMKMC1_RS05960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynBMKMC1_RS05965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynBMKMC1_RS05970	COG2045	Belongs to the ComB family
SynBMKMC1_RS05985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynBMKMC1_RS05990	COG0142	geranyltranstransferase activity
SynBMKMC1_RS05995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynBMKMC1_RS06000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynBMKMC1_RS06010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynBMKMC1_RS06015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SynBMKMC1_RS06030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynBMKMC1_RS06045	COG2146	nitrite reductase [NAD(P)H] activity
SynBMKMC1_RS06060	COG0189	ligase activity
SynBMKMC1_RS06085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynBMKMC1_RS06095	COG1132	(ABC) transporter
SynBMKMC1_RS06105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynBMKMC1_RS06110	COG0505	Belongs to the CarA family
SynBMKMC1_RS06120	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynBMKMC1_RS06125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynBMKMC1_RS06135	COG0154	amidase activity
SynBMKMC1_RS06140	COG0587	DNA-directed DNA polymerase activity
SynBMKMC1_RS06150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynBMKMC1_RS06155	COG0632	four-way junction helicase activity
SynBMKMC1_RS06170	COG0358	DNA primase activity
SynBMKMC1_RS06175	COG0798	PFAM Bile acid sodium symporter
SynBMKMC1_RS06205	COG2197	response regulator
SynBMKMC1_RS06235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynBMKMC1_RS06250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynBMKMC1_RS06255	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynBMKMC1_RS06255	COG2308	Evidence 4 Homologs of previously reported genes of
SynBMKMC1_RS06280	COG0861	Integral membrane protein TerC family
SynBMKMC1_RS06300	COG0513	Belongs to the DEAD box helicase family
SynBMKMC1_RS06305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynBMKMC1_RS06315	COG0312	modulator of DNA gyrase
SynBMKMC1_RS06320	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynBMKMC1_RS06335	COG0163	prenyltransferase activity
SynBMKMC1_RS06340	COG0557	exoribonuclease II activity
SynBMKMC1_RS06350	COG2119	membrane
SynBMKMC1_RS06370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynBMKMC1_RS06370	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynBMKMC1_RS06390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynBMKMC1_RS06395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynBMKMC1_RS06400	COG1615	UPF0182 protein
SynBMKMC1_RS06405	COG0450	alkyl hydroperoxide reductase
SynBMKMC1_RS06420	COG0739	heme binding
SynBMKMC1_RS06425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynBMKMC1_RS06460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynBMKMC1_RS06475	COG0129	dihydroxy-acid dehydratase activity
SynBMKMC1_RS06485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynBMKMC1_RS06500	COG2211	Major facilitator Superfamily
SynBMKMC1_RS06525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynBMKMC1_RS06530	COG0047	phosphoribosylformylglycinamidine synthase activity
SynBMKMC1_RS06535	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynBMKMC1_RS06545	COG0191	fructose-bisphosphate aldolase activity
SynBMKMC1_RS06550	COG0673	inositol 2-dehydrogenase activity
SynBMKMC1_RS06560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynBMKMC1_RS06565	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynBMKMC1_RS06575	COG3954	Phosphoribulokinase
SynBMKMC1_RS06580	COG0473	3-isopropylmalate dehydrogenase activity
SynBMKMC1_RS06585	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynBMKMC1_RS06590	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynBMKMC1_RS06605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynBMKMC1_RS06620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynBMKMC1_RS06625	COG2197	response regulator
SynBMKMC1_RS06635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynBMKMC1_RS06640	COG1090	epimerase
SynBMKMC1_RS06660	COG1376	ErfK ybiS ycfS ynhG family protein
SynBMKMC1_RS06685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynBMKMC1_RS06710	COG3659	wide pore channel activity
SynBMKMC1_RS06715	COG1119	ATPase activity
SynBMKMC1_RS06725	COG1051	belongs to the nudix hydrolase family
SynBMKMC1_RS06760	COG1201	RNA secondary structure unwinding
SynBMKMC1_RS06765	COG1793	dna ligase
SynBMKMC1_RS06775	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SynBMKMC1_RS06775	COG1793	dna ligase
SynBMKMC1_RS06810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynBMKMC1_RS06815	COG1175	transmembrane transport
SynBMKMC1_RS06820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynBMKMC1_RS06845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynBMKMC1_RS06870	COG0740	serine-type endopeptidase activity
SynBMKMC1_RS06875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynBMKMC1_RS06880	COG1136	(ABC) transporter
SynBMKMC1_RS06880	COG0577	efflux transmembrane transporter activity
SynBMKMC1_RS06885	COG0469	pyruvate kinase activity
SynBMKMC1_RS06905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynBMKMC1_RS06910	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynBMKMC1_RS06935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynBMKMC1_RS06940	COG0598	Magnesium transport protein CorA
SynBMKMC1_RS06950	COG3842	ATPase activity
SynBMKMC1_RS06965	COG1653	transport
SynBMKMC1_RS06970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynBMKMC1_RS06975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynBMKMC1_RS06980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynBMKMC1_RS06985	COG0326	Molecular chaperone. Has ATPase activity
SynBMKMC1_RS06995	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynBMKMC1_RS07000	COG0483	inositol monophosphate 1-phosphatase activity
SynBMKMC1_RS07005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynBMKMC1_RS07015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynBMKMC1_RS07020	COG0581	inorganic phosphate transmembrane transporter activity
SynBMKMC1_RS07025	COG0573	inorganic phosphate transmembrane transporter activity
SynBMKMC1_RS07030	COG0443	Heat shock 70 kDa protein
SynBMKMC1_RS07035	COG0484	heat shock protein binding
SynBMKMC1_RS07045	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynBMKMC1_RS07050	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynBMKMC1_RS07055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynBMKMC1_RS07060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynBMKMC1_RS07060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynBMKMC1_RS07065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynBMKMC1_RS07070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynBMKMC1_RS07095	COG0166	Belongs to the GPI family
SynBMKMC1_RS07100	COG0495	leucyl-tRNA aminoacylation
SynBMKMC1_RS07110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynBMKMC1_RS07115	COG1104	cysteine desulfurase activity
SynBMKMC1_RS07140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynBMKMC1_RS07145	COG0322	excinuclease ABC activity
SynBMKMC1_RS07155	COG3046	protein related to deoxyribodipyrimidine photolyase
SynBMKMC1_RS07160	COG1981	membrane
SynBMKMC1_RS07180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynBMKMC1_RS07185	COG1410	methionine synthase
SynBMKMC1_RS07185	COG0646	methionine synthase
SynBMKMC1_RS07210	COG2385	sporulation resulting in formation of a cellular spore
SynBMKMC1_RS07245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynBMKMC1_RS07250	COG0072	phenylalanine-tRNA ligase activity
SynBMKMC1_RS07250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynBMKMC1_RS07255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynBMKMC1_RS07260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynBMKMC1_RS07265	COG0557	exoribonuclease II activity
SynBMKMC1_RS07280	COG0363	glucosamine-6-phosphate deaminase activity
SynBMKMC1_RS07285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynBMKMC1_RS07290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynBMKMC1_RS07295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynBMKMC1_RS07300	COG1494	fructose-1,6-bisphosphatase
SynBMKMC1_RS07305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynBMKMC1_RS07315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynBMKMC1_RS07340	COG1217	gtp-binding protein TYPA
SynBMKMC1_RS07345	COG0826	peptidase U32
SynBMKMC1_RS07355	COG0644	oxidoreductase
SynBMKMC1_RS07360	COG0751	glycine-tRNA ligase activity
SynBMKMC1_RS07365	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynBMKMC1_RS07370	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynBMKMC1_RS07375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynBMKMC1_RS07385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynBMKMC1_RS07390	COG0052	Belongs to the universal ribosomal protein uS2 family
SynBMKMC1_RS07395	COG1216	Glycosyl transferase, family 2
SynBMKMC1_RS07405	COG1136	(ABC) transporter
SynBMKMC1_RS07405	COG0577	efflux transmembrane transporter activity
SynBMKMC1_RS07425	COG0612	Peptidase, M16
SynBMKMC1_RS07445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynBMKMC1_RS07450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynBMKMC1_RS07470	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynBMKMC1_RS07480	COG0174	glutamine synthetase
SynBMKMC1_RS07490	COG2226	methyltransferase
SynBMKMC1_RS07515	COG0515	serine threonine protein kinase
SynBMKMC1_RS07520	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynBMKMC1_RS07530	COG0628	permease
SynBMKMC1_RS07540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynBMKMC1_RS07540	COG0426	domain, Protein
SynBMKMC1_RS07550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynBMKMC1_RS07555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynBMKMC1_RS07560	COG0022	dehydrogenase e1 component
SynBMKMC1_RS07560	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynBMKMC1_RS07570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynBMKMC1_RS07575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynBMKMC1_RS07580	COG0572	uridine kinase
SynBMKMC1_RS07605	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynBMKMC1_RS07620	COG0271	Belongs to the BolA IbaG family
SynBMKMC1_RS07625	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynBMKMC1_RS07635	COG0745	RESPONSE REGULATOR receiver
SynBMKMC1_RS07650	COG1233	COG1233 Phytoene dehydrogenase and related
SynBMKMC1_RS07660	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynBMKMC1_RS07670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynBMKMC1_RS07710	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynBMKMC1_RS07720	COG0735	belongs to the Fur family
SynBMKMC1_RS07730	COG1799	cell septum assembly
SynBMKMC1_RS07765	COG0420	3'-5' exonuclease activity
SynBMKMC1_RS07785	COG0477	Major facilitator Superfamily
SynBMKMC1_RS07795	COG2873	o-acetylhomoserine
SynBMKMC1_RS07800	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynBMKMC1_RS07835	COG0765	amino acid transport
SynBMKMC1_RS07845	COG4597	amino acid ABC transporter
SynBMKMC1_RS07850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynBMKMC1_RS07860	COG0659	secondary active sulfate transmembrane transporter activity
SynBMKMC1_RS07900	COG0799	negative regulation of ribosome biogenesis
SynBMKMC1_RS07910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynBMKMC1_RS07920	COG1115	amino acid carrier protein
SynBMKMC1_RS07930	COG1132	(ABC) transporter
SynBMKMC1_RS07935	COG2501	S4 domain
SynBMKMC1_RS07940	COG0149	triose-phosphate isomerase activity
SynBMKMC1_RS07945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynBMKMC1_RS07955	COG1429	ligase activity, forming nitrogen-metal bonds
SynBMKMC1_RS07960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynBMKMC1_RS07970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynBMKMC1_RS07975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynBMKMC1_RS07985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynBMKMC1_RS08065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynBMKMC1_RS08070	COG0640	Transcriptional regulator
SynBMKMC1_RS08110	COG3639	organic phosphonate transmembrane transporter activity
SynBMKMC1_RS08115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynBMKMC1_RS08115	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynBMKMC1_RS08120	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynBMKMC1_RS08125	COG0436	Aminotransferase
SynBMKMC1_RS08135	COG1573	uracil-dna glycosylase
SynBMKMC1_RS08140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynBMKMC1_RS08145	COG0793	Belongs to the peptidase S41A family
SynBMKMC1_RS08165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynBMKMC1_RS08180	COG1191	sigma factor activity
SynBMKMC1_RS08185	COG1836	PFAM Integral membrane protein DUF92
SynBMKMC1_RS08210	COG1122	ATPase activity
SynBMKMC1_RS08215	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynBMKMC1_RS08230	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynBMKMC1_RS08235	COG4106	trans-aconitate 2-methyltransferase activity
SynBMKMC1_RS08240	COG0668	transmembrane transport
SynBMKMC1_RS08280	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynBMKMC1_RS08285	COG1074	ATP-dependent DNA helicase activity
SynBMKMC1_RS08290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynBMKMC1_RS08300	COG0513	Belongs to the DEAD box helicase family
SynBMKMC1_RS08315	COG0724	RNA recognition motif
SynBMKMC1_RS08325	COG1132	(ABC) transporter
SynBMKMC1_RS08330	COG0589	response to stress
SynBMKMC1_RS08330	COG0475	glutathione-regulated potassium exporter activity
SynBMKMC1_RS08370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynBMKMC1_RS08375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynBMKMC1_RS08390	COG1054	Belongs to the UPF0176 family
SynBMKMC1_RS08395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynBMKMC1_RS08400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynBMKMC1_RS08405	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynBMKMC1_RS08410	COG0019	diaminopimelate decarboxylase activity
SynBMKMC1_RS08415	COG0456	acetyltransferase
SynBMKMC1_RS08420	COG0542	response to heat
SynBMKMC1_RS08425	COG0371	Dehydrogenase
SynBMKMC1_RS08430	COG0596	Alpha beta hydrolase
SynBMKMC1_RS08430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SynBMKMC1_RS08430	COG2226	methyltransferase
SynBMKMC1_RS08440	COG0575	Belongs to the CDS family
SynBMKMC1_RS08445	COG1982	Orn Lys Arg decarboxylase major
SynBMKMC1_RS08455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynBMKMC1_RS08465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynBMKMC1_RS08470	COG0745	RESPONSE REGULATOR receiver
SynBMKMC1_RS08475	COG5002	protein histidine kinase activity
SynBMKMC1_RS08480	COG1187	pseudouridine synthase activity
SynBMKMC1_RS08490	COG1640	4-alpha-glucanotransferase
SynBMKMC1_RS08495	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SynBMKMC1_RS08510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynBMKMC1_RS08520	COG0308	aminopeptidase N
SynBMKMC1_RS08535	COG2205	protein histidine kinase activity
SynBMKMC1_RS08550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SynBMKMC1_RS08555	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynBMKMC1_RS08560	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynBMKMC1_RS08560	COG3409	Peptidoglycan-binding domain 1 protein
SynBMKMC1_RS08565	COG1797	cobyrinic acid a,c-diamide synthase activity
SynBMKMC1_RS08570	COG1254	Belongs to the acylphosphatase family
SynBMKMC1_RS08575	COG0406	alpha-ribazole phosphatase activity
SynBMKMC1_RS08595	COG0142	geranyltranstransferase activity
SynBMKMC1_RS08600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynBMKMC1_RS08605	COG1480	7TM receptor with intracellular HD hydrolase
SynBMKMC1_RS08610	COG0564	pseudouridine synthase activity
SynBMKMC1_RS08630	COG0011	TIGRFAM Protein of
SynBMKMC1_RS08650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynBMKMC1_RS08675	COG0395	ABC-type sugar transport system, permease component
SynBMKMC1_RS08680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynBMKMC1_RS08685	COG1543	Belongs to the glycosyl hydrolase 57 family
SynBMKMC1_RS08690	COG0644	oxidoreductase
SynBMKMC1_RS08695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynBMKMC1_RS08705	COG0516	GMP reductase activity
SynBMKMC1_RS08710	COG3118	belongs to the thioredoxin family
SynBMKMC1_RS08715	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynBMKMC1_RS08725	COG2010	Cytochrome c
SynBMKMC1_RS08745	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynBMKMC1_RS08750	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynBMKMC1_RS08755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynBMKMC1_RS08770	COG2166	iron-sulfur cluster assembly
SynBMKMC1_RS08775	COG0460	homoserine dehydrogenase
SynBMKMC1_RS08790	COG0601	transmembrane transport
SynBMKMC1_RS08810	COG4095	Psort location CytoplasmicMembrane, score
SynBMKMC1_RS08820	COG0012	GTP binding
SynBMKMC1_RS08825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynBMKMC1_RS08830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynBMKMC1_RS08830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynBMKMC1_RS08835	COG0215	cysteine-tRNA ligase activity
SynBMKMC1_RS08850	COG0733	neurotransmitter:sodium symporter activity
SynBMKMC1_RS08855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynBMKMC1_RS08910	COG0492	ferredoxin-NADP+ reductase activity
SynBMKMC1_RS08915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynBMKMC1_RS08925	COG1187	pseudouridine synthase activity
SynBMKMC1_RS08930	COG2226	methyltransferase
SynBMKMC1_RS08940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynBMKMC1_RS08955	COG2267	carboxylic ester hydrolase activity
SynBMKMC1_RS08960	COG0440	acetolactate synthase activity
SynBMKMC1_RS08965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynBMKMC1_RS09035	COG0424	maF-like protein
SynBMKMC1_RS09045	COG1492	cobalamin metabolic process
SynBMKMC1_RS09070	COG0432	Pfam Uncharacterised protein family UPF0047
SynBMKMC1_RS09075	COG0477	Major facilitator Superfamily
SynBMKMC1_RS09115	COG1970	mechanosensitive ion channel activity
SynBMKMC1_RS09170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynBMKMC1_RS09195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynBMKMC1_RS09200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynBMKMC1_RS09215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynBMKMC1_RS09215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynBMKMC1_RS09285	COG3119	arylsulfatase activity
SynBMKMC1_RS09290	COG3119	arylsulfatase activity
SynBMKMC1_RS09320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynBMKMC1_RS09375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynBMKMC1_RS09380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynBMKMC1_RS09385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynBMKMC1_RS09390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynBMKMC1_RS09400	COG0196	riboflavin kinase activity
SynBMKMC1_RS09405	COG0352	thiamine-phosphate diphosphorylase activity
SynBMKMC1_RS09430	COG1691	(AIR) carboxylase
SynBMKMC1_RS09450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynBMKMC1_RS09460	COG0670	Belongs to the BI1 family
SynBMKMC1_RS09465	COG1702	phosphate starvation-inducible protein PhoH
SynBMKMC1_RS09470	COG0228	four-way junction DNA binding
SynBMKMC1_RS09475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynBMKMC1_RS09490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynBMKMC1_RS09495	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynBMKMC1_RS09500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynBMKMC1_RS09505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynBMKMC1_RS09505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynBMKMC1_RS09510	COG0482	sulfurtransferase activity
SynBMKMC1_RS09515	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynBMKMC1_RS09530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynBMKMC1_RS09535	COG0134	indole-3-glycerol-phosphate synthase activity
SynBMKMC1_RS09540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynBMKMC1_RS09545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynBMKMC1_RS09560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynBMKMC1_RS09565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynBMKMC1_RS09570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynBMKMC1_RS09575	COG0285	dihydrofolate synthase activity
SynBMKMC1_RS09580	COG1357	PFAM Pentapeptide repeats (8 copies)
SynBMKMC1_RS09610	COG4948	Mandelate Racemase Muconate Lactonizing
SynBMKMC1_RS09615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynBMKMC1_RS09620	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynBMKMC1_RS09635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynBMKMC1_RS09645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynBMKMC1_RS09655	COG4956	integral membrane protein (PIN domain superfamily)
SynBMKMC1_RS09660	COG0740	serine-type endopeptidase activity
SynBMKMC1_RS09665	COG0740	serine-type endopeptidase activity
SynBMKMC1_RS09670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynBMKMC1_RS09675	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynBMKMC1_RS09700	COG0752	glycyl-tRNA synthetase alpha subunit
SynBMKMC1_RS09710	COG2226	methyltransferase
SynBMKMC1_RS09720	COG0107	imidazoleglycerol-phosphate synthase activity
SynBMKMC1_RS09730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynBMKMC1_RS09735	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynBMKMC1_RS09740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynBMKMC1_RS09740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynBMKMC1_RS09745	COG3659	wide pore channel activity
SynBMKMC1_RS09760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynBMKMC1_RS09765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynBMKMC1_RS09780	COG5002	protein histidine kinase activity
SynBMKMC1_RS09790	COG2205	protein histidine kinase activity
SynBMKMC1_RS09815	COG0745	RESPONSE REGULATOR receiver
SynBMKMC1_RS09820	COG5002	protein histidine kinase activity
SynBMKMC1_RS09850	COG0481	GTPase activity
SynBMKMC1_RS09855	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynBMKMC1_RS09865	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynBMKMC1_RS09870	COG0523	cobalamin synthesis protein
SynBMKMC1_RS09880	COG1840	ABC-type Fe3 transport system, periplasmic component
SynBMKMC1_RS09900	COG2271	Major facilitator Superfamily
SynBMKMC1_RS09910	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynBMKMC1_RS09940	COG0277	FAD linked oxidase domain protein
SynBMKMC1_RS09945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynBMKMC1_RS09955	COG1666	GTP binding
SynBMKMC1_RS09970	COG0330	HflC and HflK could
SynBMKMC1_RS09985	COG0857	belongs to the CobB CobQ family
SynBMKMC1_RS09995	COG3000	fatty acid hydroxylase
SynBMKMC1_RS09995	COG0300	oxidoreductase activity
SynBMKMC1_RS10000	COG0024	Methionine aminopeptidase
SynBMKMC1_RS10010	COG0335	large ribosomal subunit rRNA binding
SynBMKMC1_RS10030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynBMKMC1_RS10035	COG3263	regulation of cellular component size
SynBMKMC1_RS10060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynBMKMC1_RS10065	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynBMKMC1_RS10080	COG0194	GDP metabolic process
SynBMKMC1_RS10085	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynBMKMC1_RS10090	COG0805	protein transport
SynBMKMC1_RS10100	COG0723	plastoquinol--plastocyanin reductase activity
SynBMKMC1_RS10105	COG3258	Cytochrome c
SynBMKMC1_RS10110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynBMKMC1_RS10115	COG2875	Belongs to the precorrin methyltransferase family
SynBMKMC1_RS10130	COG0248	Ppx GppA phosphatase
SynBMKMC1_RS10135	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynBMKMC1_RS10140	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynBMKMC1_RS10145	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynBMKMC1_RS10155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynBMKMC1_RS10160	COG1028	Short-chain dehydrogenase reductase Sdr
SynBMKMC1_RS10170	COG0459	protein refolding
SynBMKMC1_RS10180	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynBMKMC1_RS10200	COG0109	protoheme IX farnesyltransferase activity
SynBMKMC1_RS10205	COG1612	heme a metabolic process
SynBMKMC1_RS10220	COG1845	cytochrome c oxidase, subunit III
SynBMKMC1_RS10255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynBMKMC1_RS10270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynBMKMC1_RS10275	COG1007	ATP synthesis coupled electron transport
SynBMKMC1_RS10280	COG0577	efflux transmembrane transporter activity
SynBMKMC1_RS10280	COG1136	(ABC) transporter
SynBMKMC1_RS10285	COG0745	RESPONSE REGULATOR receiver
SynBMKMC1_RS10290	COG0739	heme binding
SynBMKMC1_RS10295	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynBMKMC1_RS10295	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynBMKMC1_RS10300	COG0436	Aminotransferase
SynBMKMC1_RS10305	COG3118	belongs to the thioredoxin family
SynBMKMC1_RS10310	COG1842	Phage shock protein A
SynBMKMC1_RS10320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynBMKMC1_RS10325	COG0438	transferase activity, transferring glycosyl groups
SynBMKMC1_RS10330	COG0697	spore germination
SynBMKMC1_RS10335	COG0616	signal peptide processing
SynBMKMC1_RS10350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynBMKMC1_RS10355	COG0594	ribonuclease P activity
SynBMKMC1_RS10365	COG0706	membrane insertase activity
SynBMKMC1_RS10375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynBMKMC1_RS10385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynBMKMC1_RS10390	COG0750	zinc metalloprotease
SynBMKMC1_RS10395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynBMKMC1_RS10400	COG1185	polyribonucleotide nucleotidyltransferase activity
SynBMKMC1_RS10410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynBMKMC1_RS10755	COG1523	belongs to the glycosyl hydrolase 13 family
SynBMKMC1_RS10765	COG0776	regulation of translation
SynBMKMC1_RS10770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynBMKMC1_RS10915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SynBMKMC1_RS10965	COG2234	aminopeptidase activity
SynBMKMC1_RS11035	COG1715	Restriction endonuclease
SynBMKMC1_RS11050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynBMKMC1_RS11170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynBMKMC1_RS11170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynBMKMC1_RS11185	COG3039	Transposase
SynBMKMC1_RS11285	COG1061	Type III restriction enzyme res subunit
SynBMKMC1_RS11345	COG3311	Transcriptional regulator
SynBMKMC1_RS11350	COG1569	PIN domain
SynBMKMC1_RS11365	COG2211	Major facilitator Superfamily
SynBMKMC1_RS11370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynBMKMC1_RS11385	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynBMKMC1_RS11425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynBMKMC1_RS11440	COG0284	orotidine-5'-phosphate decarboxylase activity
SynBMKMC1_RS11460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynBMKMC1_RS11485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynBMKMC1_RS11500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynBMKMC1_RS11510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynBMKMC1_RS11515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynBMKMC1_RS11520	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynBMKMC1_RS11530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynBMKMC1_RS11540	COG0151	Belongs to the GarS family
SynBMKMC1_RS11545	COG5002	protein histidine kinase activity
SynBMKMC1_RS11550	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynBMKMC1_RS11555	COG4251	negative regulation of phosphorylation
SynBMKMC1_RS11565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynBMKMC1_RS11570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynBMKMC1_RS11585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynBMKMC1_RS11590	COG0217	transcriptional regulatory protein
SynBMKMC1_RS11600	COG0363	glucosamine-6-phosphate deaminase activity
SynBMKMC1_RS11605	COG2385	sporulation resulting in formation of a cellular spore
SynBMKMC1_RS11610	COG1234	tRNA 3'-trailer cleavage
SynBMKMC1_RS11615	COG2010	Cytochrome c
SynBMKMC1_RS11630	COG2264	protein methyltransferase activity
SynBMKMC1_RS11635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynBMKMC1_RS11655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynBMKMC1_RS11705	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynBMKMC1_RS11710	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynBMKMC1_RS11725	COG0459	protein refolding
SynBMKMC1_RS11730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynBMKMC1_RS11735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynBMKMC1_RS11740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynBMKMC1_RS11755	COG0387	Pfam Sodium calcium exchanger
SynBMKMC1_RS11760	COG0006	proline dipeptidase activity
SynBMKMC1_RS11765	COG1253	flavin adenine dinucleotide binding
SynBMKMC1_RS11770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynBMKMC1_RS11775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynBMKMC1_RS11780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynBMKMC1_RS11780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynBMKMC1_RS11790	COG3012	SEC-C Motif Domain Protein
SynBMKMC1_RS11795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynBMKMC1_RS11805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynBMKMC1_RS11815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynBMKMC1_RS11820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynBMKMC1_RS11825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynBMKMC1_RS11830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynBMKMC1_RS11835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynBMKMC1_RS11840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynBMKMC1_RS11845	COG0356	it plays a direct role in the translocation of protons across the membrane
SynBMKMC1_RS11855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynBMKMC1_RS11860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynBMKMC1_RS11880	COG0772	Belongs to the SEDS family
SynBMKMC1_RS11885	COG4232	protein-disulfide reductase activity
SynBMKMC1_RS11890	COG1333	cytochrome c biogenesis protein
SynBMKMC1_RS11895	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynBMKMC1_RS11910	COG0347	Belongs to the P(II) protein family
SynBMKMC1_RS11925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynBMKMC1_RS11935	COG0114	fumarate hydratase activity
SynBMKMC1_RS11940	COG4581	dead DEAH box helicase
SynBMKMC1_RS11945	COG0385	Bile acid
SynBMKMC1_RS11950	COG0156	8-amino-7-oxononanoate synthase activity
SynBMKMC1_RS11965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynBMKMC1_RS11965	COG4106	trans-aconitate 2-methyltransferase activity
SynBMKMC1_RS11980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynBMKMC1_RS11995	COG0357	Ribosomal RNA small subunit methyltransferase G
SynBMKMC1_RS12025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SynBMKMC1_RS12030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynBMKMC1_RS12040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynBMKMC1_RS12045	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynBMKMC1_RS12050	COG0085	RNA polymerase activity
SynBMKMC1_RS12055	COG0084	hydrolase, TatD family'
SynBMKMC1_RS12060	COG0268	Binds directly to 16S ribosomal RNA
SynBMKMC1_RS12065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynBMKMC1_RS12070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynBMKMC1_RS12075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynBMKMC1_RS12085	COG2197	response regulator
SynBMKMC1_RS12115	COG0641	radical SAM
SynBMKMC1_RS12125	COG0779	Required for maturation of 30S ribosomal subunits
SynBMKMC1_RS12130	COG0195	Participates in both transcription termination and antitermination
SynBMKMC1_RS12140	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynBMKMC1_RS12195	COG2988	succinylglutamate desuccinylase activity
SynBMKMC1_RS12210	COG0488	(ABC) transporter
SynBMKMC1_RS12230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynBMKMC1_RS12235	COG3842	ATPase activity
SynBMKMC1_RS12240	COG1193	negative regulation of DNA recombination
SynBMKMC1_RS12255	COG0113	porphobilinogen synthase activity
SynBMKMC1_RS12260	COG0484	heat shock protein binding
SynBMKMC1_RS12270	COG0659	secondary active sulfate transmembrane transporter activity
SynBMKMC1_RS12275	COG0431	NADPH-dependent FMN reductase
SynBMKMC1_RS12290	COG0300	oxidoreductase activity
SynBMKMC1_RS12380	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SynBMKMC1_RS12385	COG0732	type I restriction modification DNA specificity domain
SynBMKMC1_RS12390	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SynBMKMC1_RS12400	COG1715	Restriction endonuclease
SynBMKMC1_RS12415	COG0116	Belongs to the methyltransferase superfamily
SynBMKMC1_RS12435	COG1196	nuclear chromosome segregation
SynBMKMC1_RS12445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynBMKMC1_RS12450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynBMKMC1_RS12460	COG0439	Biotin carboxylase
SynBMKMC1_RS12475	COG0515	serine threonine protein kinase
SynBMKMC1_RS12495	COG4178	(ABC) transporter
SynBMKMC1_RS12500	COG0537	adenosine 5'-monophosphoramidase activity
SynBMKMC1_RS12505	COG0606	chelatase, subunit chli
SynBMKMC1_RS12510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynBMKMC1_RS12525	COG0242	peptide deformylase activity
SynBMKMC1_RS12535	COG0235	Class ii aldolase
SynBMKMC1_RS12540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynBMKMC1_RS12555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynBMKMC1_RS12560	COG0719	Fe-S assembly protein
SynBMKMC1_RS12565	COG0396	ATPase activity
SynBMKMC1_RS12570	COG0719	Fe-S assembly protein
SynBMKMC1_RS12575	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynBMKMC1_RS12580	COG1830	Aldolase
SynBMKMC1_RS12600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynBMKMC1_RS12615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SynBMKMC1_RS12635	COG0033	Phosphoglucomutase
SynBMKMC1_RS12645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynBMKMC1_RS12675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynBMKMC1_RS12680	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynBMKMC1_RS12685	COG0175	sulfate reduction
SynBMKMC1_RS12690	COG1252	NADH dehydrogenase
SynBMKMC1_RS12695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynBMKMC1_RS12700	COG0471	metal ion transport
SynBMKMC1_RS12700	COG3273	potassium ion transport
SynBMKMC1_RS12705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynBMKMC1_RS12710	COG0569	domain protein
SynBMKMC1_RS12715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynBMKMC1_RS12740	COG0488	(ABC) transporter
SynBMKMC1_RS12750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynBMKMC1_RS12765	COG1643	Atp-dependent helicase
SynBMKMC1_RS12770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynBMKMC1_RS12780	COG1570	exodeoxyribonuclease VII activity
SynBMKMC1_RS12785	COG1722	exodeoxyribonuclease VII activity
SynBMKMC1_RS12830	COG0483	inositol monophosphate 1-phosphatase activity
SynBMKMC1_RS12845	COG1968	undecaprenyl-diphosphatase activity
SynBMKMC1_RS12855	COG1555	photosystem II stabilization
SynBMKMC1_RS12860	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynBMKMC1_RS12870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynBMKMC1_RS12885	COG1032	radical SAM domain protein
SynBMKMC1_RS12915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynBMKMC1_RS12940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynBMKMC1_RS12950	COG0463	Glycosyl transferase, family 2
SynBMKMC1_RS12955	COG1587	Uroporphyrinogen-III synthase
SynBMKMC1_RS12970	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynBMKMC1_RS12975	COG0316	Belongs to the HesB IscA family
SynBMKMC1_RS12995	COG1090	epimerase
SynBMKMC1_RS13015	COG0484	heat shock protein binding
SynBMKMC1_RS13020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynBMKMC1_RS13025	COG3659	wide pore channel activity
SynBMKMC1_RS13030	COG3659	wide pore channel activity
SynBMKMC1_RS13060	COG1122	ATPase activity
SynBMKMC1_RS13070	COG0745	RESPONSE REGULATOR receiver
SynBMKMC1_RS13080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynBMKMC1_RS13085	COG2217	Heavy metal translocating P-type atpase
SynBMKMC1_RS13090	COG3063	Type IV pilus biogenesis stability protein PilW
SynBMKMC1_RS13095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynBMKMC1_RS13105	COG0416	fatty acid biosynthetic process
SynBMKMC1_RS13110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynBMKMC1_RS13115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynBMKMC1_RS13130	COG1214	PFAM Peptidase M22, glycoprotease
SynBMKMC1_RS13140	COG0617	tRNA 3'-terminal CCA addition
SynBMKMC1_RS13150	COG1562	ergosterol biosynthetic process
SynBMKMC1_RS13155	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynBMKMC1_RS13155	COG0493	'glutamate synthase
SynBMKMC1_RS13170	COG0583	DNA-binding transcription factor activity
SynBMKMC1_RS13180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynBMKMC1_RS13185	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynBMKMC1_RS13195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynBMKMC1_RS13220	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynBMKMC1_RS13225	COG0713	ATP synthesis coupled electron transport
SynBMKMC1_RS13230	COG0839	Belongs to the complex I subunit 6 family
SynBMKMC1_RS13235	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynBMKMC1_RS13240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynBMKMC1_RS13245	COG0372	Belongs to the citrate synthase family
SynBMKMC1_RS13250	COG2062	phosphohistidine phosphatase, SixA
SynBMKMC1_RS13265	COG1420	regulation of RNA biosynthetic process
SynBMKMC1_RS13275	COG0133	tryptophan synthase activity
SynBMKMC1_RS13280	COG2226	methyltransferase
SynBMKMC1_RS13285	COG0023	Translation Initiation Factor
SynBMKMC1_RS13290	COG0529	Catalyzes the synthesis of activated sulfate
SynBMKMC1_RS13295	COG0628	permease
SynBMKMC1_RS13300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynBMKMC1_RS13310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynBMKMC1_RS13320	COG0564	pseudouridine synthase activity
SynBMKMC1_RS13325	COG0745	RESPONSE REGULATOR receiver
SynBMKMC1_RS13335	COG1104	cysteine desulfurase activity
SynBMKMC1_RS13345	COG0275	rRNA processing
SynBMKMC1_RS13350	COG0649	NAD binding
SynBMKMC1_RS13355	COG0824	Thioesterase
SynBMKMC1_RS13370	COG1575	Belongs to the MenA family. Type 1 subfamily
SynBMKMC1_RS13380	COG0189	ligase activity
SynBMKMC1_RS13385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynBMKMC1_RS13410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynBMKMC1_RS13415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynBMKMC1_RS13420	COG0512	Glutamine amidotransferase of anthranilate synthase
SynBMKMC1_RS13430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynBMKMC1_RS13450	COG0252	asparaginase activity
SynBMKMC1_RS13460	COG0018	arginyl-trna synthetase
SynBMKMC1_RS13465	COG0157	Belongs to the NadC ModD family
SynBMKMC1_RS13480	COG0242	peptide deformylase activity
SynBMKMC1_RS13485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynBMKMC1_RS13500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynBMKMC1_RS13505	COG4172	Belongs to the ABC transporter superfamily
SynBMKMC1_RS13525	COG0564	pseudouridine synthase activity
SynBMKMC1_RS13535	COG0589	response to stress
SynBMKMC1_RS13540	COG0126	phosphoglycerate kinase activity
SynBMKMC1_RS13550	COG2084	Dehydrogenase
SynBMKMC1_RS13560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynBMKMC1_RS13565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynBMKMC1_RS13595	COG0167	dihydroorotate dehydrogenase activity
SynBMKMC1_RS13610	COG0222	ribosome binding
SynBMKMC1_RS13615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynBMKMC1_RS13620	COG0081	regulation of translation
SynBMKMC1_RS13625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynBMKMC1_RS13630	COG0250	Participates in transcription elongation, termination and antitermination
SynBMKMC1_RS13635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynBMKMC1_RS13640	COG0542	response to heat
SynBMKMC1_RS13650	COG0148	phosphopyruvate hydratase activity
SynBMKMC1_RS13655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynBMKMC1_RS13670	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynBMKMC1_RS13675	COG0237	dephospho-CoA kinase activity
SynBMKMC1_RS13680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynBMKMC1_RS13685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynBMKMC1_RS13685	COG2022	thiamine diphosphate biosynthetic process
SynBMKMC1_RS13695	COG0105	UTP biosynthetic process
SynBMKMC1_RS13700	COG1166	arginine decarboxylase activity
SynBMKMC1_RS13715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynBMKMC1_RS13725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynBMKMC1_RS13750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynBMKMC1_RS13750	COG0426	domain, Protein
SynBMKMC1_RS13755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynBMKMC1_RS13755	COG0426	domain, Protein
SynBMKMC1_RS13765	COG1741	Belongs to the pirin family
SynBMKMC1_RS13790	COG0509	glycine decarboxylation via glycine cleavage system
SynBMKMC1_RS13795	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynBMKMC1_RS13815	COG0359	binds to the 23S rRNA
SynBMKMC1_RS13820	COG0305	Participates in initiation and elongation during chromosome replication
SynBMKMC1_RS13820	COG1372	Participates in initiation and elongation during chromosome replication
SynBMKMC1_RS13820	COG1372	Participates in initiation and elongation during chromosome replication
SynBMKMC1_RS13820	COG0305	Participates in initiation and elongation during chromosome replication
SynBMKMC1_RS13825	COG0445	tRNA wobble uridine modification
SynBMKMC1_RS13865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynBMKMC1_RS13880	COG0398	Pfam SNARE associated Golgi protein
SynBMKMC1_RS13895	COG0668	transmembrane transport
SynBMKMC1_RS13915	COG0525	valine-tRNA ligase activity
SynBMKMC1_RS13925	COG3264	Mechanosensitive ion channel
SynBMKMC1_RS13925	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynBMKMC1_RS13945	COG4221	oxidoreductase activity
SynBMKMC1_RS13970	COG3956	TIGRFAM MazG family protein
SynBMKMC1_RS13980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynBMKMC1_RS13995	COG0010	Belongs to the arginase family
SynBMKMC1_RS14010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynBMKMC1_RS14015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynBMKMC1_RS14020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynBMKMC1_RS14025	COG0783	Belongs to the Dps family
SynBMKMC1_RS14030	COG0504	CTP synthase activity
SynBMKMC1_RS14035	COG0602	queuosine metabolic process
SynBMKMC1_RS14045	COG4574	serine-type endopeptidase inhibitor activity
SynBMKMC1_RS14050	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynBMKMC1_RS14055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynBMKMC1_RS14065	COG0531	amino acid
SynBMKMC1_RS14075	COG0366	Alpha amylase catalytic
SynBMKMC1_RS14080	COG0463	Glycosyl transferase, family 2
SynBMKMC1_RS14115	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynBMKMC1_RS14120	COG0830	nickel cation binding
SynBMKMC1_RS14125	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynBMKMC1_RS14130	COG0829	nickel cation binding
SynBMKMC1_RS14135	COG0831	urea catabolic process
SynBMKMC1_RS14140	COG0832	Belongs to the urease beta subunit family
SynBMKMC1_RS14145	COG0804	urea catabolic process
SynBMKMC1_RS14160	COG0367	asparagine synthase
SynBMKMC1_RS14165	COG0540	Belongs to the ATCase OTCase family
SynBMKMC1_RS14180	COG2308	Evidence 4 Homologs of previously reported genes of
SynBMKMC1_RS14200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynBMKMC1_RS14205	COG0746	molybdenum cofactor guanylyltransferase activity
SynBMKMC1_RS14210	COG2223	nitrite transmembrane transporter activity
SynBMKMC1_RS14215	COG0243	molybdopterin cofactor binding
SynBMKMC1_RS14235	COG0315	cyclic pyranopterin monophosphate synthase activity
SynBMKMC1_RS14240	COG0303	'Molybdopterin
SynBMKMC1_RS14245	COG0314	molybdopterin synthase activity
SynBMKMC1_RS14250	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SynBMKMC1_RS14255	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynBMKMC1_RS14260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynBMKMC1_RS14275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynBMKMC1_RS14285	COG2116	formate transmembrane transporter activity
SynBMKMC1_RS14295	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynBMKMC1_RS14305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynBMKMC1_RS14320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynBMKMC1_RS14325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynBMKMC1_RS14330	COG0170	dolichyl monophosphate biosynthetic process
SynBMKMC1_RS14340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynBMKMC1_RS14345	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynBMKMC1_RS14365	COG0788	formyltetrahydrofolate deformylase activity
SynBMKMC1_RS14390	COG0443	Heat shock 70 kDa protein
SynBMKMC1_RS14395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynBMKMC1_RS14405	COG0360	Binds together with S18 to 16S ribosomal RNA
SynBMKMC1_RS14415	COG0137	argininosuccinate synthase activity
SynBMKMC1_RS14430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynBMKMC1_RS14450	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynBMKMC1_RS14455	COG0438	transferase activity, transferring glycosyl groups
SynBMKMC1_RS14465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynBMKMC1_RS14470	COG0497	DNA recombination
SynBMKMC1_RS14475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynBMKMC1_RS14485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine