locus-tag	class	description
H8F24_RS00025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_RS00030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F24_RS00040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F24_RS00045	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
H8F24_RS00065	COG4451	ribulose bisphosphate carboxylase, small
H8F24_RS00070	COG1850	ribulose-bisphosphate carboxylase activity
H8F24_RS00075	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F24_RS00090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8F24_RS00095	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F24_RS00100	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F24_RS00105	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F24_RS00110	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H8F24_RS00135	COG0730	response to heat
H8F24_RS00140	COG0095	Lipoate-protein ligase
H8F24_RS00145	COG0517	IMP dehydrogenase activity
H8F24_RS00145	COG1994	Peptidase M50
H8F24_RS00150	COG0135	phosphoribosylanthranilate isomerase activity
H8F24_RS00160	COG0302	gtp cyclohydrolase
H8F24_RS00170	COG0825	malonyl-CoA metabolic process
H8F24_RS00175	COG5322	oxidoreductase activity
H8F24_RS00180	COG3396	Phenylacetate-CoA oxygenase
H8F24_RS00190	COG0539	negative regulation of cytoplasmic translation
H8F24_RS00205	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H8F24_RS00225	COG0737	Belongs to the 5'-nucleotidase family
H8F24_RS00230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8F24_RS00230	COG0574	Belongs to the PEP-utilizing enzyme family
H8F24_RS00250	COG0028	Belongs to the TPP enzyme family
H8F24_RS00260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_RS00280	COG0528	UMP kinase activity
H8F24_RS00285	COG0233	cytoplasmic translational termination
H8F24_RS00290	COG0644	oxidoreductase
H8F24_RS00300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8F24_RS00320	COG0588	phosphoglycerate mutase activity
H8F24_RS00330	COG0681	Belongs to the peptidase S26 family
H8F24_RS00350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F24_RS00355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8F24_RS00365	COG0442	prolyl-tRNA aminoacylation
H8F24_RS00375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8F24_RS00380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F24_RS00410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8F24_RS00420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8F24_RS00425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_RS00430	COG1215	transferase activity, transferring glycosyl groups
H8F24_RS00450	COG0181	hydroxymethylbilane synthase activity
H8F24_RS00470	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H8F24_RS00475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_RS00480	COG3659	wide pore channel activity
H8F24_RS00490	COG0786	glutamate:sodium symporter activity
H8F24_RS00500	COG2066	Belongs to the glutaminase family
H8F24_RS00540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F24_RS00580	COG0426	domain, Protein
H8F24_RS00580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F24_RS00585	COG0284	orotidine-5'-phosphate decarboxylase activity
H8F24_RS00590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8F24_RS00600	COG2197	response regulator
H8F24_RS00615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8F24_RS00635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F24_RS00645	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F24_RS00650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8F24_RS00655	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8F24_RS00665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8F24_RS00675	COG0151	Belongs to the GarS family
H8F24_RS00680	COG5002	protein histidine kinase activity
H8F24_RS00685	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8F24_RS00705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8F24_RS00710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F24_RS00715	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8F24_RS00720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8F24_RS00725	COG0217	transcriptional regulatory protein
H8F24_RS00730	COG0363	glucosamine-6-phosphate deaminase activity
H8F24_RS00735	COG2385	sporulation resulting in formation of a cellular spore
H8F24_RS00740	COG1234	tRNA 3'-trailer cleavage
H8F24_RS00745	COG2010	Cytochrome c
H8F24_RS00760	COG2264	protein methyltransferase activity
H8F24_RS00765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8F24_RS00785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8F24_RS00810	COG0443	Heat shock 70 kDa protein
H8F24_RS00825	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H8F24_RS00850	COG0459	protein refolding
H8F24_RS00855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H8F24_RS00860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8F24_RS00865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8F24_RS00875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8F24_RS00925	COG0006	proline dipeptidase activity
H8F24_RS00930	COG1253	flavin adenine dinucleotide binding
H8F24_RS00935	COG1160	GTP binding
H8F24_RS00940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8F24_RS00945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F24_RS00945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8F24_RS00950	COG0686	Belongs to the AlaDH PNT family
H8F24_RS00955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F24_RS00965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F24_RS00975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8F24_RS00980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8F24_RS00990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8F24_RS00995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8F24_RS01015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F24_RS01020	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F24_RS01040	COG0772	Belongs to the SEDS family
H8F24_RS01055	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8F24_RS01060	COG0347	Belongs to the P(II) protein family
H8F24_RS01075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H8F24_RS01085	COG1088	dTDP-glucose 4,6-dehydratase activity
H8F24_RS01095	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H8F24_RS01110	COG4581	dead DEAH box helicase
H8F24_RS01115	COG0385	Bile acid
H8F24_RS01120	COG0156	8-amino-7-oxononanoate synthase activity
H8F24_RS01135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8F24_RS01135	COG4106	trans-aconitate 2-methyltransferase activity
H8F24_RS01140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8F24_RS01155	COG0357	Ribosomal RNA small subunit methyltransferase G
H8F24_RS01185	COG2223	nitrite transmembrane transporter activity
H8F24_RS01190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8F24_RS01200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8F24_RS01205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8F24_RS01210	COG0085	RNA polymerase activity
H8F24_RS01215	COG0084	hydrolase, TatD family'
H8F24_RS01220	COG0268	Binds directly to 16S ribosomal RNA
H8F24_RS01225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8F24_RS01230	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8F24_RS01240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F24_RS01245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H8F24_RS01255	COG0779	Required for maturation of 30S ribosomal subunits
H8F24_RS01260	COG0195	Participates in both transcription termination and antitermination
H8F24_RS01270	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8F24_RS01300	COG0484	heat shock protein binding
H8F24_RS01315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8F24_RS01325	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS01365	COG2274	protein secretion by the type I secretion system
H8F24_RS01380	COG1216	Glycosyl transferase, family 2
H8F24_RS01380	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS01410	COG2988	succinylglutamate desuccinylase activity
H8F24_RS01415	COG0435	Glutathione S-transferase
H8F24_RS01425	COG0488	(ABC) transporter
H8F24_RS01440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8F24_RS01445	COG3842	ATPase activity
H8F24_RS01450	COG1193	negative regulation of DNA recombination
H8F24_RS01460	COG0113	porphobilinogen synthase activity
H8F24_RS01465	COG0484	heat shock protein binding
H8F24_RS01525	COG4974	Belongs to the 'phage' integrase family
H8F24_RS01640	COG0798	PFAM Bile acid sodium symporter
H8F24_RS01750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F24_RS01770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F24_RS01810	COG0288	reversible hydration of carbon dioxide
H8F24_RS01870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F24_RS01905	COG2801	Transposase and inactivated derivatives
H8F24_RS01945	COG3328	transposase activity
H8F24_RS02080	COG5002	protein histidine kinase activity
H8F24_RS02080	COG2198	Histidine kinase
H8F24_RS02080	COG0784	Response regulator, receiver
H8F24_RS02100	COG1012	belongs to the aldehyde dehydrogenase family
H8F24_RS02105	COG1388	LysM domain
H8F24_RS02105	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8F24_RS02110	COG0514	ATP-dependent DNA helicase (RecQ)
H8F24_RS02115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8F24_RS02120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H8F24_RS02130	COG3842	ATPase activity
H8F24_RS02145	COG1653	transport
H8F24_RS02150	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H8F24_RS02165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8F24_RS02170	COG0235	Class ii aldolase
H8F24_RS02180	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8F24_RS02220	COG1538	Outer membrane efflux protein
H8F24_RS02230	COG1968	undecaprenyl-diphosphatase activity
H8F24_RS02240	COG1555	photosystem II stabilization
H8F24_RS02245	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H8F24_RS02250	COG4243	Vitamin k epoxide reductase
H8F24_RS02255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F24_RS02270	COG1032	radical SAM domain protein
H8F24_RS02305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8F24_RS02330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8F24_RS02335	COG1472	Belongs to the glycosyl hydrolase 3 family
H8F24_RS02340	COG1587	Uroporphyrinogen-III synthase
H8F24_RS02355	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H8F24_RS02360	COG0316	Belongs to the HesB IscA family
H8F24_RS02380	COG1090	epimerase
H8F24_RS02395	COG0484	heat shock protein binding
H8F24_RS02400	COG3659	wide pore channel activity
H8F24_RS02405	COG3659	wide pore channel activity
H8F24_RS02450	COG1122	ATPase activity
H8F24_RS02460	COG0745	RESPONSE REGULATOR receiver
H8F24_RS02470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8F24_RS02475	COG2217	Heavy metal translocating P-type atpase
H8F24_RS02480	COG3063	Type IV pilus biogenesis stability protein PilW
H8F24_RS02485	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H8F24_RS02490	COG0745	RESPONSE REGULATOR receiver
H8F24_RS02495	COG0416	fatty acid biosynthetic process
H8F24_RS02500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8F24_RS02505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8F24_RS02520	COG1214	PFAM Peptidase M22, glycoprotease
H8F24_RS02530	COG0617	tRNA 3'-terminal CCA addition
H8F24_RS02545	COG1562	ergosterol biosynthetic process
H8F24_RS02550	COG0493	'glutamate synthase
H8F24_RS02550	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H8F24_RS02565	COG0583	DNA-binding transcription factor activity
H8F24_RS02575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F24_RS02580	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_RS02595	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8F24_RS02605	COG2197	response regulator
H8F24_RS02615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8F24_RS02620	COG0713	ATP synthesis coupled electron transport
H8F24_RS02625	COG0839	Belongs to the complex I subunit 6 family
H8F24_RS02635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8F24_RS02640	COG0372	Belongs to the citrate synthase family
H8F24_RS02645	COG2062	phosphohistidine phosphatase, SixA
H8F24_RS02655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8F24_RS02660	COG1420	regulation of RNA biosynthetic process
H8F24_RS02670	COG0133	tryptophan synthase activity
H8F24_RS02680	COG0023	Translation Initiation Factor
H8F24_RS02690	COG2376	Dihydroxyacetone kinase
H8F24_RS02700	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H8F24_RS02705	COG2116	formate transmembrane transporter activity
H8F24_RS02710	COG0018	arginyl-trna synthetase
H8F24_RS02725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F24_RS02740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8F24_RS02745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8F24_RS02780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8F24_RS02785	COG0189	ligase activity
H8F24_RS02790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_RS02800	COG1575	Belongs to the MenA family. Type 1 subfamily
H8F24_RS02810	COG0318	PFAM AMP-dependent synthetase and ligase
H8F24_RS02825	COG0824	Thioesterase
H8F24_RS02840	COG0649	NAD binding
H8F24_RS02845	COG0275	rRNA processing
H8F24_RS02855	COG1104	cysteine desulfurase activity
H8F24_RS02870	COG0564	pseudouridine synthase activity
H8F24_RS02885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F24_RS02895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H8F24_RS02900	COG0628	permease
H8F24_RS02905	COG0529	Catalyzes the synthesis of activated sulfate
H8F24_RS02915	COG1799	cell septum assembly
H8F24_RS02930	COG1119	ATPase activity
H8F24_RS02970	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_RS03030	COG2144	transferase activity, transferring acyl groups
H8F24_RS03050	COG2226	methyltransferase
H8F24_RS03090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_RS03115	COG0105	UTP biosynthetic process
H8F24_RS03120	COG2022	thiamine diphosphate biosynthetic process
H8F24_RS03120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F24_RS03125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8F24_RS03145	COG0237	dephospho-CoA kinase activity
H8F24_RS03155	COG4260	virion core protein, lumpy skin disease virus
H8F24_RS03160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H8F24_RS03175	COG2755	lipolytic protein G-D-S-L family
H8F24_RS03175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8F24_RS03185	COG2801	Transposase and inactivated derivatives
H8F24_RS03205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F24_RS03210	COG0148	phosphopyruvate hydratase activity
H8F24_RS03215	COG0346	lactoylglutathione lyase activity
H8F24_RS03220	COG0542	response to heat
H8F24_RS03225	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8F24_RS03235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8F24_RS03240	COG0081	regulation of translation
H8F24_RS03245	COG0765	amino acid transport
H8F24_RS03260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8F24_RS03265	COG0222	ribosome binding
H8F24_RS03275	COG0328	RNA-DNA hybrid ribonuclease activity
H8F24_RS03280	COG0167	dihydroorotate dehydrogenase activity
H8F24_RS03310	COG2801	Transposase and inactivated derivatives
H8F24_RS03350	COG0714	Associated with various cellular activities
H8F24_RS03355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F24_RS03360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8F24_RS03370	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H8F24_RS03375	COG2084	Dehydrogenase
H8F24_RS03420	COG0126	phosphoglycerate kinase activity
H8F24_RS03425	COG0589	response to stress
H8F24_RS03435	COG0564	pseudouridine synthase activity
H8F24_RS03450	COG4172	Belongs to the ABC transporter superfamily
H8F24_RS03455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8F24_RS03475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8F24_RS03480	COG0157	Belongs to the NadC ModD family
H8F24_RS03495	COG0641	radical SAM
H8F24_RS03510	COG1231	oxidoreductase activity
H8F24_RS03520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_RS03530	COG0475	glutathione-regulated potassium exporter activity
H8F24_RS03545	COG0628	permease
H8F24_RS03555	COG0415	Belongs to the DNA photolyase family
H8F24_RS03580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8F24_RS03590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F24_RS03660	COG2205	protein histidine kinase activity
H8F24_RS03660	COG5002	protein histidine kinase activity
H8F24_RS03660	COG0784	Response regulator, receiver
H8F24_RS03675	COG3437	response regulator, receiver
H8F24_RS03695	COG5002	protein histidine kinase activity
H8F24_RS03695	COG2205	protein histidine kinase activity
H8F24_RS03695	COG0784	Response regulator, receiver
H8F24_RS03770	COG2801	Transposase and inactivated derivatives
H8F24_RS03835	COG3447	MASE1 domain protein
H8F24_RS03835	COG5001	Diguanylate cyclase
H8F24_RS03835	COG5002	protein histidine kinase activity
H8F24_RS03885	COG3956	TIGRFAM MazG family protein
H8F24_RS03895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8F24_RS03900	COG0010	Belongs to the arginase family
H8F24_RS03915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8F24_RS03920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8F24_RS03925	COG1215	transferase activity, transferring glycosyl groups
H8F24_RS03930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8F24_RS03930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8F24_RS03935	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_RS03940	COG1051	belongs to the nudix hydrolase family
H8F24_RS03950	COG3328	transposase activity
H8F24_RS03955	COG3328	transposase activity
H8F24_RS03980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8F24_RS04005	COG2770	Histidine kinase
H8F24_RS04005	COG2208	phosphoserine phosphatase activity
H8F24_RS04035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8F24_RS04045	COG0783	Belongs to the Dps family
H8F24_RS04055	COG0602	queuosine metabolic process
H8F24_RS04060	COG4574	serine-type endopeptidase inhibitor activity
H8F24_RS04065	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8F24_RS04085	COG0411	ABC transporter
H8F24_RS04105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H8F24_RS04110	COG0830	nickel cation binding
H8F24_RS04115	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H8F24_RS04125	COG0831	urea catabolic process
H8F24_RS04130	COG0832	Belongs to the urease beta subunit family
H8F24_RS04135	COG0804	urea catabolic process
H8F24_RS04155	COG2308	Evidence 4 Homologs of previously reported genes of
H8F24_RS04170	COG0058	SHG alpha-glucan phosphorylase activity
H8F24_RS04190	COG5001	Diguanylate cyclase
H8F24_RS04190	COG3300	MHYT domain
H8F24_RS04195	COG5001	Diguanylate cyclase
H8F24_RS04215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F24_RS04220	COG3264	Mechanosensitive ion channel
H8F24_RS04220	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H8F24_RS04230	COG2226	methyltransferase
H8F24_RS04250	COG0525	valine-tRNA ligase activity
H8F24_RS04295	COG1970	mechanosensitive ion channel activity
H8F24_RS04375	COG1970	mechanosensitive ion channel activity
H8F24_RS04385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8F24_RS04390	COG0398	Pfam SNARE associated Golgi protein
H8F24_RS04405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F24_RS04445	COG0445	tRNA wobble uridine modification
H8F24_RS04450	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H8F24_RS04485	COG2124	cytochrome p450
H8F24_RS04500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8F24_RS04505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8F24_RS04510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8F24_RS04515	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_RS04520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8F24_RS04550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8F24_RS04560	COG0571	ribonuclease III activity
H8F24_RS04595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8F24_RS04600	COG0390	transport system, permease component
H8F24_RS04620	COG0058	SHG alpha-glucan phosphorylase activity
H8F24_RS04625	COG0475	glutathione-regulated potassium exporter activity
H8F24_RS04650	COG0277	FAD linked oxidase domain protein
H8F24_RS04660	COG0435	Glutathione S-transferase
H8F24_RS04665	COG0247	lactate metabolic process
H8F24_RS04670	COG0538	isocitrate dehydrogenase activity
H8F24_RS04680	COG5398	heme oxygenase
H8F24_RS04695	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS04715	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS04720	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS04740	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8F24_RS04755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8F24_RS04765	COG0617	tRNA 3'-terminal CCA addition
H8F24_RS04770	COG0709	Synthesizes selenophosphate from selenide and ATP
H8F24_RS04775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8F24_RS04780	COG0124	histidyl-tRNA synthetase
H8F24_RS04785	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8F24_RS04790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F24_RS04820	COG4447	cellulose binding
H8F24_RS04825	COG1773	rubredoxin
H8F24_RS04830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_RS04835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_RS04840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_RS04845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H8F24_RS04850	COG3842	ATPase activity
H8F24_RS04860	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F24_RS04860	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F24_RS04870	COG0415	Belongs to the DNA photolyase family
H8F24_RS04875	COG0189	ligase activity
H8F24_RS04875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8F24_RS04900	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8F24_RS04945	COG0131	Imidazoleglycerol-phosphate dehydratase
H8F24_RS04955	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H8F24_RS04980	COG1595	DNA-templated transcription, initiation
H8F24_RS04990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8F24_RS04995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8F24_RS05005	COG0354	folic acid binding
H8F24_RS05010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8F24_RS05030	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_RS05085	COG2226	methyltransferase
H8F24_RS05110	COG2217	Heavy metal translocating P-type atpase
H8F24_RS05165	COG0071	Belongs to the small heat shock protein (HSP20) family
H8F24_RS05205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F24_RS05230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8F24_RS05235	COG0511	ligase activity, forming carbon-carbon bonds
H8F24_RS05240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8F24_RS05245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F24_RS05250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8F24_RS05255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F24_RS05260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8F24_RS05265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8F24_RS05270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8F24_RS05275	COG1162	GTPase activity
H8F24_RS05285	COG0484	heat shock protein binding
H8F24_RS05290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8F24_RS05295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8F24_RS05305	COG1459	type II secretion system
H8F24_RS05315	COG2081	HI0933 family
H8F24_RS05320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F24_RS05325	COG0724	RNA recognition motif
H8F24_RS05330	COG0165	Argininosuccinate lyase
H8F24_RS05335	COG2208	phosphoserine phosphatase activity
H8F24_RS05340	COG0552	protein localization to endoplasmic reticulum
H8F24_RS05345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F24_RS05360	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8F24_RS05370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8F24_RS05375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H8F24_RS05390	COG0592	DNA-directed DNA polymerase activity
H8F24_RS05395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8F24_RS05405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F24_RS05410	COG0497	DNA recombination
H8F24_RS05425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8F24_RS05475	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS05485	COG1316	TRANSCRIPTIONal
H8F24_RS05490	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8F24_RS05505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F24_RS05520	COG0137	argininosuccinate synthase activity
H8F24_RS05540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F24_RS05545	COG0443	Heat shock 70 kDa protein
H8F24_RS05550	COG2022	thiamine diphosphate biosynthetic process
H8F24_RS05550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F24_RS05560	COG0788	formyltetrahydrofolate deformylase activity
H8F24_RS05595	COG1049	propionate catabolic process, 2-methylcitrate cycle
H8F24_RS05600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8F24_RS05610	COG0170	dolichyl monophosphate biosynthetic process
H8F24_RS05615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_RS05620	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8F24_RS05635	COG1053	succinate dehydrogenase
H8F24_RS05645	COG0315	cyclic pyranopterin monophosphate synthase activity
H8F24_RS05650	COG0393	Putative heavy-metal-binding
H8F24_RS05655	COG0303	'Molybdopterin
H8F24_RS05660	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS05665	COG0561	phosphatase activity
H8F24_RS05665	COG3100	YcgL domain-containing protein
H8F24_RS05675	COG0730	response to heat
H8F24_RS05680	COG0314	molybdopterin synthase activity
H8F24_RS05690	COG0590	tRNA wobble adenosine to inosine editing
H8F24_RS05725	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8F24_RS05735	COG1597	lipid kinase activity
H8F24_RS05735	COG1803	Methylglyoxal synthase
H8F24_RS05795	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F24_RS05800	COG3657	addiction module killer protein
H8F24_RS05815	COG4974	Belongs to the 'phage' integrase family
H8F24_RS05850	COG2801	Transposase and inactivated derivatives
H8F24_RS05880	COG1484	DNA-dependent DNA replication
H8F24_RS05935	COG4974	Belongs to the 'phage' integrase family
H8F24_RS06000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8F24_RS06010	COG2223	nitrite transmembrane transporter activity
H8F24_RS06015	COG0243	molybdopterin cofactor binding
H8F24_RS06025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8F24_RS06035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F24_RS06050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8F24_RS06050	COG1648	precorrin-2 dehydrogenase activity
H8F24_RS06070	COG0426	domain, Protein
H8F24_RS06070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F24_RS06080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F24_RS06080	COG0426	domain, Protein
H8F24_RS06085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F24_RS06085	COG1773	rubredoxin
H8F24_RS06105	COG0509	glycine decarboxylation via glycine cleavage system
H8F24_RS06110	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H8F24_RS06130	COG0359	binds to the 23S rRNA
H8F24_RS06135	COG1372	Participates in initiation and elongation during chromosome replication
H8F24_RS06135	COG0305	Participates in initiation and elongation during chromosome replication
H8F24_RS06135	COG0305	Participates in initiation and elongation during chromosome replication
H8F24_RS06135	COG1372	Participates in initiation and elongation during chromosome replication
H8F24_RS06190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8F24_RS06205	COG1473	amidohydrolase
H8F24_RS06225	COG0515	serine threonine protein kinase
H8F24_RS06225	COG1357	PFAM Pentapeptide repeats (8 copies)
H8F24_RS06235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F24_RS06240	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H8F24_RS06265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8F24_RS06270	COG0745	RESPONSE REGULATOR receiver
H8F24_RS06295	COG0629	single-stranded DNA binding
H8F24_RS06300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8F24_RS06305	COG0802	atpase or kinase
H8F24_RS06310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F24_RS06340	COG0174	glutamine synthetase
H8F24_RS06345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_RS06350	COG2239	Acts as a magnesium transporter
H8F24_RS06365	COG0386	Belongs to the glutathione peroxidase family
H8F24_RS06370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8F24_RS06375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8F24_RS06385	COG1372	Participates in initiation and elongation during chromosome replication
H8F24_RS06385	COG0187	DNA topoisomerase II activity
H8F24_RS06390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8F24_RS06405	COG1725	Transcriptional regulator
H8F24_RS06410	COG1045	serine acetyltransferase
H8F24_RS06425	COG0653	protein targeting
H8F24_RS06430	COG0297	glycogen (starch) synthase activity
H8F24_RS06435	COG0454	-acetyltransferase
H8F24_RS06455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F24_RS06525	COG1215	transferase activity, transferring glycosyl groups
H8F24_RS06540	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS06545	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H8F24_RS06550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F24_RS06555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8F24_RS06565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8F24_RS06570	COG2082	Precorrin-8x methylmutase
H8F24_RS06580	COG0527	aspartate kinase activity
H8F24_RS06590	COG0556	nucleotide-excision repair
H8F24_RS06605	COG0037	tRNA processing
H8F24_RS06615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H8F24_RS06620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8F24_RS06625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8F24_RS06630	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8F24_RS06635	COG0740	serine-type endopeptidase activity
H8F24_RS06640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8F24_RS06650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H8F24_RS06655	COG1215	transferase activity, transferring glycosyl groups
H8F24_RS06665	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H8F24_RS06670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H8F24_RS06690	COG2022	thiamine diphosphate biosynthetic process
H8F24_RS06710	COG0768	penicillin binding
H8F24_RS06725	COG0519	Catalyzes the synthesis of GMP from XMP
H8F24_RS06725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8F24_RS06840	COG1216	Glycosyl transferase, family 2
H8F24_RS07085	COG2026	Addiction module toxin, RelE StbE family
H8F24_RS07145	COG0402	S-adenosylhomocysteine deaminase activity
H8F24_RS07150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H8F24_RS07150	COG0784	Response regulator, receiver
H8F24_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_RS07220	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H8F24_RS07245	COG0673	inositol 2-dehydrogenase activity
H8F24_RS07255	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8F24_RS07265	COG2267	carboxylic ester hydrolase activity
H8F24_RS07270	COG0596	Alpha beta hydrolase
H8F24_RS07295	COG1484	DNA-dependent DNA replication
H8F24_RS07310	COG0402	S-adenosylhomocysteine deaminase activity
H8F24_RS07330	COG0402	S-adenosylhomocysteine deaminase activity
H8F24_RS07335	COG0784	Response regulator, receiver
H8F24_RS07335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H8F24_RS07420	COG3263	regulation of cellular component size
H8F24_RS07445	COG2801	Transposase and inactivated derivatives
H8F24_RS07450	COG3039	Transposase
H8F24_RS07525	COG0318	PFAM AMP-dependent synthetase and ligase
H8F24_RS07530	COG1253	flavin adenine dinucleotide binding
H8F24_RS07535	COG0673	inositol 2-dehydrogenase activity
H8F24_RS07555	COG0343	queuine tRNA-ribosyltransferase activity
H8F24_RS07560	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H8F24_RS07580	COG0138	bifunctional purine biosynthesis protein purh
H8F24_RS07595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8F24_RS07600	COG1489	DNA binding
H8F24_RS07605	COG0728	peptidoglycan biosynthetic process
H8F24_RS07650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8F24_RS07655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F24_RS07660	COG1058	Belongs to the CinA family
H8F24_RS07660	COG1546	Belongs to the CinA family
H8F24_RS07665	COG3224	Antibiotic biosynthesis monooxygenase
H8F24_RS07670	COG2860	membrane
H8F24_RS07675	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8F24_RS07680	COG0066	3-isopropylmalate dehydratase activity
H8F24_RS07715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8F24_RS07720	COG0193	aminoacyl-tRNA hydrolase activity
H8F24_RS07735	COG4372	Transposase
H8F24_RS07745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_RS07755	COG0717	Belongs to the dCTP deaminase family
H8F24_RS07770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8F24_RS07785	COG0741	lytic transglycosylase activity
H8F24_RS07795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8F24_RS07810	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8F24_RS07830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8F24_RS07850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8F24_RS07870	COG2094	Belongs to the DNA glycosylase MPG family
H8F24_RS07875	COG0540	Belongs to the ATCase OTCase family
H8F24_RS07890	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F24_RS07935	COG3536	Protein conserved in bacteria
H8F24_RS07940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8F24_RS07955	COG0529	Catalyzes the synthesis of activated sulfate
H8F24_RS07955	COG2046	Belongs to the sulfate adenylyltransferase family
H8F24_RS07960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F24_RS07965	COG0800	Aldolase
H8F24_RS07970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8F24_RS08005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F24_RS08010	COG3119	arylsulfatase activity
H8F24_RS08025	COG3386	PFAM SMP-30 Gluconolaconase
H8F24_RS08045	COG5002	protein histidine kinase activity
H8F24_RS08055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8F24_RS08060	COG0436	Aminotransferase
H8F24_RS08070	COG1530	ribonuclease E activity
H8F24_RS08075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8F24_RS08085	COG0077	Prephenate dehydratase
H8F24_RS08085	COG1605	Chorismate mutase
H8F24_RS08090	COG2226	methyltransferase
H8F24_RS08100	COG0051	transcription antitermination factor activity, RNA binding
H8F24_RS08105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8F24_RS08110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8F24_RS08115	COG0049	tRNA binding
H8F24_RS08120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8F24_RS08135	COG0067	glutamate synthase
H8F24_RS08135	COG0070	glutamate synthase
H8F24_RS08135	COG0069	glutamate synthase activity
H8F24_RS08140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8F24_RS08150	COG3447	MASE1 domain protein
H8F24_RS08150	COG5001	Diguanylate cyclase
H8F24_RS08150	COG5002	protein histidine kinase activity
H8F24_RS08170	COG2885	chlorophyll binding
H8F24_RS08175	COG2885	chlorophyll binding
H8F24_RS08190	COG0463	Glycosyl transferase, family 2
H8F24_RS08210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8F24_RS08220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8F24_RS08230	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8F24_RS08235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H8F24_RS08240	COG0101	tRNA pseudouridine synthase activity
H8F24_RS08250	COG0202	RNA polymerase activity
H8F24_RS08255	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H8F24_RS08260	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H8F24_RS08265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H8F24_RS08270	COG0563	adenylate kinase activity
H8F24_RS08275	COG0201	protein transport
H8F24_RS08280	COG0200	Binds to the 23S rRNA
H8F24_RS08285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H8F24_RS08290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8F24_RS08295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8F24_RS08300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8F24_RS08305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8F24_RS08310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8F24_RS08315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H8F24_RS08320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8F24_RS08325	COG0255	Belongs to the universal ribosomal protein uL29 family
H8F24_RS08335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8F24_RS08340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H8F24_RS08345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8F24_RS08355	COG0089	rRNA binding
H8F24_RS08360	COG0088	Forms part of the polypeptide exit tunnel
H8F24_RS08365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8F24_RS08380	COG3854	ATPases associated with a variety of cellular activities
H8F24_RS08425	COG3001	Fructosamine kinase
H8F24_RS08450	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H8F24_RS08455	COG1606	tRNA processing
H8F24_RS08465	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8F24_RS08470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8F24_RS08485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8F24_RS08490	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H8F24_RS08495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8F24_RS08505	COG2205	protein histidine kinase activity
H8F24_RS08510	COG0772	Belongs to the SEDS family
H8F24_RS08515	COG0489	protein tyrosine kinase activity
H8F24_RS08520	COG0408	coproporphyrinogen oxidase activity
H8F24_RS08565	COG0667	Aldo Keto reductase
H8F24_RS08575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8F24_RS08580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8F24_RS08585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8F24_RS08585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8F24_RS08590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8F24_RS08595	COG1413	lyase activity
H8F24_RS08630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8F24_RS08645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F24_RS08680	COG1070	Carbohydrate kinase
H8F24_RS08685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8F24_RS08695	COG0539	negative regulation of cytoplasmic translation
H8F24_RS08700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8F24_RS08725	COG0589	response to stress
H8F24_RS08735	COG0758	DNA mediated transformation
H8F24_RS08740	COG2890	protein-(glutamine-N5) methyltransferase activity
H8F24_RS08745	COG0009	L-threonylcarbamoyladenylate synthase
H8F24_RS08755	COG3706	GGDEF domain
H8F24_RS08760	COG5001	Diguanylate cyclase
H8F24_RS08760	COG4251	negative regulation of phosphorylation
H8F24_RS08760	COG3706	GGDEF domain
H8F24_RS08760	COG2203	Gaf domain
H8F24_RS08785	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8F24_RS08790	COG2894	cell division
H8F24_RS08805	COG2059	Chromate
H8F24_RS08810	COG0850	regulation of cytokinetic process
H8F24_RS08815	COG1078	dGTPase activity
H8F24_RS08820	COG0793	Belongs to the peptidase S41A family
H8F24_RS08825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8F24_RS08830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8F24_RS08885	COG1570	exodeoxyribonuclease VII activity
H8F24_RS08895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_RS08905	COG1643	Atp-dependent helicase
H8F24_RS08920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F24_RS08935	COG0488	(ABC) transporter
H8F24_RS08965	COG0569	domain protein
H8F24_RS08970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8F24_RS08975	COG0450	alkyl hydroperoxide reductase
H8F24_RS08980	COG0471	metal ion transport
H8F24_RS08980	COG3273	potassium ion transport
H8F24_RS08985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8F24_RS08995	COG1252	NADH dehydrogenase
H8F24_RS09000	COG0175	sulfate reduction
H8F24_RS09005	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8F24_RS09010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F24_RS09030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F24_RS09035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8F24_RS09070	COG0033	Phosphoglucomutase
H8F24_RS09095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8F24_RS09110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F24_RS09130	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
H8F24_RS09135	COG0719	Fe-S assembly protein
H8F24_RS09140	COG0396	ATPase activity
H8F24_RS09145	COG0719	Fe-S assembly protein
H8F24_RS09150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8F24_RS09180	COG2197	response regulator
H8F24_RS09190	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8F24_RS09205	COG3347	Dehydrogenase
H8F24_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_RS09275	COG0562	UDP-galactopyranose mutase
H8F24_RS09325	COG3328	transposase activity
H8F24_RS09370	COG3328	transposase activity
H8F24_RS09400	COG3328	transposase activity
H8F24_RS09440	COG3328	transposase activity
H8F24_RS09470	COG0242	peptide deformylase activity
H8F24_RS09485	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H8F24_RS09500	COG0537	adenosine 5'-monophosphoramidase activity
H8F24_RS09505	COG4178	(ABC) transporter
H8F24_RS09525	COG0515	serine threonine protein kinase
H8F24_RS09540	COG0439	Biotin carboxylase
H8F24_RS09550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F24_RS09555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F24_RS09565	COG1196	nuclear chromosome segregation
H8F24_RS09580	COG0116	Belongs to the methyltransferase superfamily
H8F24_RS09625	COG3550	peptidyl-serine autophosphorylation
H8F24_RS09650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F24_RS09650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8F24_RS09655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8F24_RS09665	COG3328	transposase activity
H8F24_RS09755	COG0202	RNA polymerase activity
H8F24_RS09765	COG2801	Transposase and inactivated derivatives
H8F24_RS09785	COG0443	Heat shock 70 kDa protein
H8F24_RS09795	COG2361	Protein of unknown function DUF86
H8F24_RS09805	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F24_RS09885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F24_RS09900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F24_RS09940	COG2801	Transposase and inactivated derivatives
H8F24_RS09955	COG0297	glycogen (starch) synthase activity
H8F24_RS09960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F24_RS09965	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8F24_RS09975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8F24_RS09985	COG0740	serine-type endopeptidase activity
H8F24_RS09990	COG0740	serine-type endopeptidase activity
H8F24_RS09995	COG4956	integral membrane protein (PIN domain superfamily)
H8F24_RS10000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8F24_RS10005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8F24_RS10015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H8F24_RS10030	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8F24_RS10035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F24_RS10040	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H8F24_RS10040	COG2066	Belongs to the glutaminase family
H8F24_RS10045	COG4948	Mandelate Racemase Muconate Lactonizing
H8F24_RS10090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8F24_RS10095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8F24_RS10100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8F24_RS10115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F24_RS10120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F24_RS10125	COG0134	indole-3-glycerol-phosphate synthase activity
H8F24_RS10130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H8F24_RS10135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8F24_RS10145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8F24_RS10150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8F24_RS10175	COG0306	phosphate transporter
H8F24_RS10195	COG0706	membrane insertase activity
H8F24_RS10205	COG0594	ribonuclease P activity
H8F24_RS10210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H8F24_RS10225	COG0616	signal peptide processing
H8F24_RS10230	COG0697	spore germination
H8F24_RS10235	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS10250	COG1842	Phage shock protein A
H8F24_RS10255	COG3118	belongs to the thioredoxin family
H8F24_RS10260	COG0436	Aminotransferase
H8F24_RS10265	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H8F24_RS10265	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H8F24_RS10270	COG0739	heme binding
H8F24_RS10275	COG1136	(ABC) transporter
H8F24_RS10285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8F24_RS10300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8F24_RS10340	COG1845	cytochrome c oxidase, subunit III
H8F24_RS10345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8F24_RS10360	COG0109	protoheme IX farnesyltransferase activity
H8F24_RS10375	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H8F24_RS10380	COG0459	protein refolding
H8F24_RS10390	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_RS10395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8F24_RS10405	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8F24_RS10415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F24_RS10430	COG0482	sulfurtransferase activity
H8F24_RS10435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8F24_RS10435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8F24_RS10440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_RS10445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8F24_RS10455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8F24_RS10465	COG1702	phosphate starvation-inducible protein PhoH
H8F24_RS10470	COG0670	Belongs to the BI1 family
H8F24_RS10480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8F24_RS10490	COG0336	Belongs to the RNA methyltransferase TrmD family
H8F24_RS10500	COG1691	(AIR) carboxylase
H8F24_RS10520	COG0196	riboflavin kinase activity
H8F24_RS10530	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8F24_RS10535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8F24_RS10540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8F24_RS10545	COG0745	RESPONSE REGULATOR receiver
H8F24_RS10560	COG0651	ATP synthesis coupled electron transport
H8F24_RS10610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F24_RS10610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F24_RS10615	COG0668	transmembrane transport
H8F24_RS10630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F24_RS10635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8F24_RS10640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8F24_RS10670	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8F24_RS10700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H8F24_RS10730	COG1185	polyribonucleotide nucleotidyltransferase activity
H8F24_RS10735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H8F24_RS10740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8F24_RS10745	COG0750	zinc metalloprotease
H8F24_RS10750	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8F24_RS10755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8F24_RS10805	COG0347	Belongs to the P(II) protein family
H8F24_RS10815	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8F24_RS10840	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_RS10850	COG0586	Pfam SNARE associated Golgi protein
H8F24_RS10860	COG2205	protein histidine kinase activity
H8F24_RS10870	COG1126	abc transporter atp-binding protein
H8F24_RS10875	COG0765	amino acid transport
H8F24_RS10880	COG4597	amino acid ABC transporter
H8F24_RS10885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8F24_RS10890	COG0530	calcium, potassium:sodium antiporter activity
H8F24_RS10895	COG0371	Dehydrogenase
H8F24_RS10900	COG0596	Alpha beta hydrolase
H8F24_RS10915	COG2203	Gaf domain
H8F24_RS10915	COG5001	Diguanylate cyclase
H8F24_RS10915	COG4251	negative regulation of phosphorylation
H8F24_RS10915	COG3706	GGDEF domain
H8F24_RS10940	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8F24_RS10950	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H8F24_RS10955	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H8F24_RS10960	COG0298	carbon dioxide binding
H8F24_RS10965	COG0674	pyruvate-flavodoxin oxidoreductase activity
H8F24_RS10965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8F24_RS10965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H8F24_RS10965	COG1013	pyruvate-flavodoxin oxidoreductase activity
H8F24_RS10970	COG0167	dihydroorotate dehydrogenase activity
H8F24_RS10975	COG0409	Hydrogenase expression formation protein
H8F24_RS10990	COG0579	oxidoreductase
H8F24_RS11000	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8F24_RS11005	COG0739	heme binding
H8F24_RS11010	COG0723	plastoquinol--plastocyanin reductase activity
H8F24_RS11020	COG0805	protein transport
H8F24_RS11025	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H8F24_RS11030	COG0194	GDP metabolic process
H8F24_RS11045	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8F24_RS11050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_RS11060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H8F24_RS11070	COG0012	GTP binding
H8F24_RS11105	COG0601	transmembrane transport
H8F24_RS11120	COG0460	homoserine dehydrogenase
H8F24_RS11125	COG2166	iron-sulfur cluster assembly
H8F24_RS11135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8F24_RS11140	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8F24_RS11145	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F24_RS11165	COG2010	Cytochrome c
H8F24_RS11180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8F24_RS11185	COG1611	Belongs to the LOG family
H8F24_RS11190	COG3118	belongs to the thioredoxin family
H8F24_RS11195	COG0516	GMP reductase activity
H8F24_RS11210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8F24_RS11215	COG0644	oxidoreductase
H8F24_RS11220	COG1543	Belongs to the glycosyl hydrolase 57 family
H8F24_RS11230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8F24_RS11235	COG0395	ABC-type sugar transport system, permease component
H8F24_RS11255	COG1480	7TM receptor with intracellular HD hydrolase
H8F24_RS11270	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H8F24_RS11290	COG1254	Belongs to the acylphosphatase family
H8F24_RS11295	COG1797	cobyrinic acid a,c-diamide synthase activity
H8F24_RS11300	COG3409	Peptidoglycan-binding domain 1 protein
H8F24_RS11300	COG3429	Glucose-6-phosphate dehydrogenase subunit
H8F24_RS11305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8F24_RS11330	COG2205	protein histidine kinase activity
H8F24_RS11345	COG0308	aminopeptidase N
H8F24_RS11355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8F24_RS11370	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
H8F24_RS11375	COG1640	4-alpha-glucanotransferase
H8F24_RS11385	COG1187	pseudouridine synthase activity
H8F24_RS11390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_RS11400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F24_RS11405	COG1982	Orn Lys Arg decarboxylase major
H8F24_RS11410	COG2241	protein methyltransferase activity
H8F24_RS11410	COG2242	protein methyltransferase activity
H8F24_RS11415	COG0575	Belongs to the CDS family
H8F24_RS11445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F24_RS11460	COG0375	protein maturation
H8F24_RS11470	COG3259	Nickel-dependent hydrogenase
H8F24_RS11500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_RS11550	COG0776	regulation of translation
H8F24_RS11560	COG1523	belongs to the glycosyl hydrolase 13 family
H8F24_RS11580	COG1215	transferase activity, transferring glycosyl groups
H8F24_RS11585	COG1472	Belongs to the glycosyl hydrolase 3 family
H8F24_RS11660	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H8F24_RS11670	COG1064	alcohol dehydrogenase
H8F24_RS11675	COG1233	COG1233 Phytoene dehydrogenase and related
H8F24_RS11700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8F24_RS11705	COG0271	Belongs to the BolA IbaG family
H8F24_RS11720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8F24_RS11735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8F24_RS11745	COG1074	ATP-dependent DNA helicase activity
H8F24_RS11750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F24_RS11760	COG0513	Belongs to the DEAD box helicase family
H8F24_RS11770	COG0724	RNA recognition motif
H8F24_RS11790	COG1132	(ABC) transporter
H8F24_RS11845	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8F24_RS11850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8F24_RS11855	COG2205	protein histidine kinase activity
H8F24_RS11860	COG0745	RESPONSE REGULATOR receiver
H8F24_RS11875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F24_RS11880	COG3695	enzyme binding
H8F24_RS11885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F24_RS11885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8F24_RS11890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8F24_RS11895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F24_RS11905	COG0107	imidazoleglycerol-phosphate synthase activity
H8F24_RS11915	COG2226	methyltransferase
H8F24_RS11920	COG0752	glycyl-tRNA synthetase alpha subunit
H8F24_RS11940	COG0582	viral genome integration into host DNA
H8F24_RS12100	COG5002	protein histidine kinase activity
H8F24_RS12105	COG0745	RESPONSE REGULATOR receiver
H8F24_RS12250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F24_RS12305	COG2217	Heavy metal translocating P-type atpase
H8F24_RS12335	COG0789	Transcriptional regulator
H8F24_RS12370	COG2442	InterPro IPR007367
H8F24_RS12405	COG2267	carboxylic ester hydrolase activity
H8F24_RS12425	COG1484	DNA-dependent DNA replication
H8F24_RS12515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F24_RS12525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F24_RS12540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F24_RS12565	COG0121	glutamine amidotransferase
H8F24_RS12575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8F24_RS12580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8F24_RS12625	COG2226	methyltransferase
H8F24_RS12630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_RS12650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F24_RS12660	COG1136	(ABC) transporter
H8F24_RS12660	COG0577	efflux transmembrane transporter activity
H8F24_RS12690	COG4584	PFAM Integrase catalytic
H8F24_RS12765	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H8F24_RS12790	COG3328	transposase activity
H8F24_RS12815	COG1054	Belongs to the UPF0176 family
H8F24_RS12820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8F24_RS12825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8F24_RS12830	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H8F24_RS12835	COG0019	diaminopimelate decarboxylase activity
H8F24_RS12845	COG0542	response to heat
H8F24_RS12900	COG0724	RNA recognition motif
H8F24_RS12925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8F24_RS12950	COG2326	polyphosphate kinase activity
H8F24_RS12955	COG2326	polyphosphate kinase activity
H8F24_RS12980	COG0531	amino acid
H8F24_RS13005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F24_RS13075	COG2211	Major facilitator Superfamily
H8F24_RS13080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8F24_RS13095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H8F24_RS13100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8F24_RS13105	COG1799	cell septum assembly
H8F24_RS13110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8F24_RS13120	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H8F24_RS13125	COG1160	GTP binding
H8F24_RS13135	COG0477	Major facilitator Superfamily
H8F24_RS13150	COG3527	Alpha-acetolactate decarboxylase
H8F24_RS13155	COG0028	Belongs to the TPP enzyme family
H8F24_RS13170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F24_RS13180	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8F24_RS13185	COG2918	glutathione biosynthetic process
H8F24_RS13185	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8F24_RS13200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8F24_RS13215	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS13230	COG1381	Involved in DNA repair and RecF pathway recombination
H8F24_RS13235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H8F24_RS13240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8F24_RS13245	COG0321	lipoyl(octanoyl) transferase activity
H8F24_RS13250	COG1022	Amp-dependent synthetase and ligase
H8F24_RS13265	COG0531	amino acid
H8F24_RS13270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8F24_RS13275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8F24_RS13290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H8F24_RS13295	COG1492	cobalamin metabolic process
H8F24_RS13305	COG0424	maF-like protein
H8F24_RS13335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F24_RS13340	COG0440	acetolactate synthase activity
H8F24_RS13345	COG2267	carboxylic ester hydrolase activity
H8F24_RS13350	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H8F24_RS13395	COG1187	pseudouridine synthase activity
H8F24_RS13400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H8F24_RS13405	COG0492	ferredoxin-NADP+ reductase activity
H8F24_RS13435	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8F24_RS13460	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8F24_RS13470	COG0733	neurotransmitter:sodium symporter activity
H8F24_RS13525	COG0489	protein tyrosine kinase activity
H8F24_RS13585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8F24_RS13640	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS13655	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS13665	COG0367	asparagine synthase
H8F24_RS13685	COG0438	transferase activity, transferring glycosyl groups
H8F24_RS13690	COG0110	maltose O-acetyltransferase activity
H8F24_RS13730	COG0656	L-ascorbic acid biosynthetic process
H8F24_RS13745	COG3039	Transposase
H8F24_RS13765	COG2942	2-epimerase
H8F24_RS13770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H8F24_RS13770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H8F24_RS13775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F24_RS13780	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8F24_RS13820	COG0297	glycogen (starch) synthase activity
H8F24_RS13825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F24_RS13935	COG0215	cysteine-tRNA ligase activity
H8F24_RS13940	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H8F24_RS13945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F24_RS13955	COG0475	glutathione-regulated potassium exporter activity
H8F24_RS13955	COG0589	response to stress
H8F24_RS13990	COG0367	asparagine synthase
H8F24_RS13995	COG0540	Belongs to the ATCase OTCase family
H8F24_RS14025	COG0799	negative regulation of ribosome biogenesis
H8F24_RS14035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8F24_RS14045	COG1115	amino acid carrier protein
H8F24_RS14060	COG1132	(ABC) transporter
H8F24_RS14065	COG2501	S4 domain
H8F24_RS14070	COG0149	triose-phosphate isomerase activity
H8F24_RS14075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8F24_RS14090	COG1132	(ABC) transporter
H8F24_RS14095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F24_RS14115	COG0745	RESPONSE REGULATOR receiver
H8F24_RS14120	COG1429	ligase activity, forming nitrogen-metal bonds
H8F24_RS14125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8F24_RS14135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F24_RS14140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8F24_RS14150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8F24_RS14220	COG0598	Magnesium transport protein CorA
H8F24_RS14240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_RS14245	COG0745	RESPONSE REGULATOR receiver
H8F24_RS14250	COG5002	protein histidine kinase activity
H8F24_RS14255	COG0659	secondary active sulfate transmembrane transporter activity
H8F24_RS14265	COG0659	secondary active sulfate transmembrane transporter activity
H8F24_RS14270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8F24_RS14285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F24_RS14295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F24_RS14315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8F24_RS14340	COG3128	pkhd-type hydroxylase
H8F24_RS14350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8F24_RS14365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8F24_RS14380	COG2199	diguanylate cyclase activity
H8F24_RS14390	COG0358	DNA primase activity
H8F24_RS14405	COG0632	four-way junction helicase activity
H8F24_RS14410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8F24_RS14420	COG0587	DNA-directed DNA polymerase activity
H8F24_RS14425	COG0154	amidase activity
H8F24_RS14440	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H8F24_RS14450	COG0505	Belongs to the CarA family
H8F24_RS14455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8F24_RS14465	COG1132	(ABC) transporter
H8F24_RS14475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F24_RS14510	COG0505	Belongs to the CarA family
H8F24_RS14525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F24_RS14550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8F24_RS14555	COG0798	PFAM Bile acid sodium symporter
H8F24_RS14590	COG3551	Protein conserved in bacteria
H8F24_RS14595	COG3039	Transposase
H8F24_RS14640	COG3321	synthase
H8F24_RS14640	COG0604	alcohol dehydrogenase
H8F24_RS14650	COG2801	Transposase and inactivated derivatives
H8F24_RS14720	COG1484	DNA-dependent DNA replication
H8F24_RS14775	COG1484	DNA-dependent DNA replication
H8F24_RS14835	COG3328	transposase activity
H8F24_RS14880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H8F24_RS14885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8F24_RS14900	COG2345	Transcriptional regulator
H8F24_RS14905	COG0154	amidase activity
H8F24_RS14990	COG2326	polyphosphate kinase activity
H8F24_RS15000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8F24_RS15005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8F24_RS15020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F24_RS15045	COG0142	geranyltranstransferase activity
H8F24_RS15050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H8F24_RS15065	COG2045	Belongs to the ComB family
H8F24_RS15070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H8F24_RS15075	COG1959	2 iron, 2 sulfur cluster binding
H8F24_RS15085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8F24_RS15090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F24_RS15090	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H8F24_RS15095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F24_RS15105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8F24_RS15115	COG0297	glycogen (starch) synthase activity
H8F24_RS15120	COG1376	ErfK ybiS ycfS ynhG family protein
H8F24_RS15125	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H8F24_RS15130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H8F24_RS15135	COG0681	Belongs to the peptidase S26 family
H8F24_RS15150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F24_RS15155	COG1121	(ABC) transporter
H8F24_RS15190	COG0180	Tryptophanyl-tRNA synthetase
H8F24_RS15210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8F24_RS15215	COG0837	glucose binding
H8F24_RS15220	COG0083	homoserine kinase activity
H8F24_RS15225	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F24_RS15230	COG0339	signal peptide processing
H8F24_RS15245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8F24_RS15250	COG1940	carbohydrate kinase activity
H8F24_RS15285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8F24_RS15290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8F24_RS15300	COG2010	Cytochrome c
H8F24_RS15325	COG0542	response to heat
H8F24_RS15330	COG0432	Pfam Uncharacterised protein family UPF0047
H8F24_RS15345	COG1283	sodium-dependent phosphate transmembrane transporter activity
H8F24_RS15375	COG1741	Belongs to the pirin family
H8F24_RS15380	COG0281	malic enzyme
H8F24_RS15405	COG4942	peptidase
H8F24_RS15415	COG0347	Belongs to the P(II) protein family
H8F24_RS15420	COG0004	ammonium transporteR
H8F24_RS15435	COG0792	nuclease activity
H8F24_RS15445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8F24_RS15450	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8F24_RS15460	COG0022	dehydrogenase e1 component
H8F24_RS15465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8F24_RS15470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8F24_RS15485	COG0628	permease
H8F24_RS15490	COG3310	Protein conserved in bacteria
H8F24_RS15495	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H8F24_RS15500	COG0515	serine threonine protein kinase
H8F24_RS15520	COG2226	methyltransferase
H8F24_RS15525	COG0174	glutamine synthetase
H8F24_RS15535	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8F24_RS15540	COG0037	tRNA processing
H8F24_RS15540	COG0590	tRNA wobble adenosine to inosine editing
H8F24_RS15555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8F24_RS15560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8F24_RS15580	COG0612	Peptidase, M16
H8F24_RS15600	COG1136	(ABC) transporter
H8F24_RS15610	COG1216	Glycosyl transferase, family 2
H8F24_RS15615	COG0052	Belongs to the universal ribosomal protein uS2 family
H8F24_RS15620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8F24_RS15630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8F24_RS15635	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8F24_RS15645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F24_RS15650	COG0751	glycine-tRNA ligase activity
H8F24_RS15655	COG0644	oxidoreductase
H8F24_RS15665	COG0826	peptidase U32
H8F24_RS15670	COG1217	gtp-binding protein TYPA
H8F24_RS15685	COG1137	ATPase activity
H8F24_RS15695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8F24_RS15700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H8F24_RS15705	COG1494	fructose-1,6-bisphosphatase
H8F24_RS15710	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8F24_RS15715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F24_RS15720	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H8F24_RS15725	COG0363	glucosamine-6-phosphate deaminase activity
H8F24_RS15740	COG0129	dihydroxy-acid dehydratase activity
H8F24_RS15750	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8F24_RS15780	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8F24_RS15785	COG0047	phosphoribosylformylglycinamidine synthase activity
H8F24_RS15790	COG1619	proteins homologs of microcin C7 resistance protein MccF
H8F24_RS15795	COG0450	alkyl hydroperoxide reductase
H8F24_RS15815	COG0484	heat shock protein binding
H8F24_RS15820	COG0076	glutamate decarboxylase activity
H8F24_RS15825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F24_RS15830	COG0640	Transcriptional regulator
H8F24_RS15835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F24_RS15890	COG1695	Transcriptional regulator
H8F24_RS15935	COG2361	Protein of unknown function DUF86
H8F24_RS15970	COG1487	ribonuclease activity
H8F24_RS16065	COG2105	PFAM AIG2 family protein
H8F24_RS16080	COG0739	heme binding
H8F24_RS16085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8F24_RS16120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F24_RS16135	COG0557	exoribonuclease II activity
H8F24_RS16140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8F24_RS16145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H8F24_RS16150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F24_RS16150	COG0072	phenylalanine-tRNA ligase activity
H8F24_RS16155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8F24_RS16185	COG2385	sporulation resulting in formation of a cellular spore
H8F24_RS16195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8F24_RS16220	COG1410	methionine synthase
H8F24_RS16220	COG0646	methionine synthase
H8F24_RS16225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8F24_RS16245	COG1981	membrane
H8F24_RS16255	COG0641	radical SAM
H8F24_RS16285	COG3046	protein related to deoxyribodipyrimidine photolyase
H8F24_RS16295	COG0322	excinuclease ABC activity
H8F24_RS16305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8F24_RS16315	COG2027	D-alanyl-D-alanine carboxypeptidase
H8F24_RS16330	COG1104	cysteine desulfurase activity
H8F24_RS16335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8F24_RS16345	COG0495	leucyl-tRNA aminoacylation
H8F24_RS16350	COG0166	Belongs to the GPI family
H8F24_RS16375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8F24_RS16380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8F24_RS16385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8F24_RS16385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8F24_RS16390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F24_RS16395	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8F24_RS16400	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H8F24_RS16410	COG0484	heat shock protein binding
H8F24_RS16415	COG0443	Heat shock 70 kDa protein
H8F24_RS16420	COG0573	inorganic phosphate transmembrane transporter activity
H8F24_RS16425	COG0581	inorganic phosphate transmembrane transporter activity
H8F24_RS16430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8F24_RS16445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F24_RS16450	COG0483	inositol monophosphate 1-phosphatase activity
H8F24_RS16455	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H8F24_RS16470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H8F24_RS16475	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F24_RS16515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8F24_RS16520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8F24_RS16530	COG0762	integral membrane protein
H8F24_RS16550	COG0469	pyruvate kinase activity
H8F24_RS16555	COG1136	(ABC) transporter
H8F24_RS16555	COG0577	efflux transmembrane transporter activity
H8F24_RS16565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F24_RS16570	COG0740	serine-type endopeptidase activity
H8F24_RS16590	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8F24_RS16650	COG3328	transposase activity
H8F24_RS16705	COG4584	PFAM Integrase catalytic
H8F24_RS16780	COG2801	Transposase and inactivated derivatives
H8F24_RS16785	COG2801	Transposase and inactivated derivatives
H8F24_RS16805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H8F24_RS16810	COG1175	transmembrane transport
H8F24_RS16815	COG0514	ATP-dependent DNA helicase (RecQ)
H8F24_RS16820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8F24_RS16860	COG3588	fructose-bisphosphate aldolase
H8F24_RS16865	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8F24_RS16865	COG1793	dna ligase
H8F24_RS16890	COG0778	Nitroreductase
H8F24_RS16920	COG0569	domain protein
H8F24_RS16920	COG0475	glutathione-regulated potassium exporter activity
H8F24_RS16925	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_RS16940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8F24_RS16965	COG0861	Integral membrane protein TerC family
H8F24_RS16975	COG0513	Belongs to the DEAD box helicase family
H8F24_RS16990	COG1252	NADH dehydrogenase
H8F24_RS16995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8F24_RS17005	COG0312	modulator of DNA gyrase
H8F24_RS17010	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H8F24_RS17025	COG0163	prenyltransferase activity
H8F24_RS17030	COG0557	exoribonuclease II activity
H8F24_RS17065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H8F24_RS17065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8F24_RS17085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8F24_RS17090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F24_RS17105	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8F24_RS17110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8F24_RS17120	COG0191	fructose-bisphosphate aldolase activity
H8F24_RS17125	COG0673	inositol 2-dehydrogenase activity
H8F24_RS17135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8F24_RS17140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8F24_RS17150	COG3954	Phosphoribulokinase
H8F24_RS17155	COG0473	3-isopropylmalate dehydrogenase activity
H8F24_RS17160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F24_RS17165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8F24_RS17180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8F24_RS17195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8F24_RS17205	COG3447	MASE1 domain protein
H8F24_RS17205	COG5002	protein histidine kinase activity
H8F24_RS17205	COG5001	Diguanylate cyclase
H8F24_RS17210	COG0114	fumarate hydratase activity
H8F24_RS17215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8F24_RS17220	COG2197	response regulator
H8F24_RS17230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8F24_RS17250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8F24_RS17280	COG1201	RNA secondary structure unwinding
H8F24_RS17285	COG1793	dna ligase
H8F24_RS17285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8F24_RS17290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F24_RS17315	COG1136	(ABC) transporter
H8F24_RS17315	COG0577	efflux transmembrane transporter activity
H8F24_RS17340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8F24_RS17390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8F24_RS17450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F24_RS17460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F24_RS17475	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
H8F24_RS17485	COG4245	von Willebrand factor, type A
H8F24_RS17495	COG2234	aminopeptidase activity
H8F24_RS17510	COG4456	Virulence-associated protein
H8F24_RS17560	COG1160	GTP binding
H8F24_RS17695	COG1484	DNA-dependent DNA replication
H8F24_RS17730	COG1028	Short-chain dehydrogenase reductase Sdr
H8F24_RS17805	COG1122	ATPase activity
H8F24_RS17845	COG0159	tryptophan synthase activity
H8F24_RS17865	COG2010	Cytochrome c
H8F24_RS17905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_RS17920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F24_RS17925	COG1121	(ABC) transporter
H8F24_RS17940	COG0140	phosphoribosyl-ATP diphosphatase activity
H8F24_RS17940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8F24_RS17945	COG0720	synthase
H8F24_RS17950	COG0701	Predicted permease
H8F24_RS17970	COG3659	wide pore channel activity
H8F24_RS17985	COG3706	GGDEF domain
H8F24_RS17995	COG0523	cobalamin synthesis protein
H8F24_RS18010	COG1840	ABC-type Fe3 transport system, periplasmic component
H8F24_RS18030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F24_RS18035	COG0735	belongs to the Fur family
H8F24_RS18075	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H8F24_RS18080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F24_RS18100	COG0708	Exodeoxyribonuclease III
H8F24_RS18110	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8F24_RS18115	COG4251	negative regulation of phosphorylation
H8F24_RS18130	COG2119	membrane
H8F24_RS18140	COG1116	anion transmembrane transporter activity
H8F24_RS18145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8F24_RS18165	COG0375	protein maturation
H8F24_RS18170	COG0010	Belongs to the arginase family
H8F24_RS18190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8F24_RS18205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F24_RS18205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F24_RS18220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8F24_RS18235	COG0335	large ribosomal subunit rRNA binding
H8F24_RS18245	COG0024	Methionine aminopeptidase
H8F24_RS18250	COG3000	fatty acid hydroxylase
H8F24_RS18250	COG0300	oxidoreductase activity
H8F24_RS18260	COG0857	belongs to the CobB CobQ family
H8F24_RS18275	COG0330	HflC and HflK could
H8F24_RS18300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F24_RS18310	COG1666	GTP binding
H8F24_RS18360	COG0405	Gamma-glutamyltransferase
H8F24_RS18390	COG1845	cytochrome c oxidase, subunit III
H8F24_RS18465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8F24_RS18470	COG0277	FAD linked oxidase domain protein
H8F24_RS18530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8F24_RS18535	COG4106	trans-aconitate 2-methyltransferase activity
H8F24_RS18550	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8F24_RS18565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8F24_RS18570	COG1122	ATPase activity
H8F24_RS18590	COG1836	PFAM Integral membrane protein DUF92
H8F24_RS18605	COG3639	organic phosphonate transmembrane transporter activity
H8F24_RS18610	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H8F24_RS18630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8F24_RS18640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H8F24_RS18645	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H8F24_RS18655	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H8F24_RS18660	COG0436	Aminotransferase
H8F24_RS18680	COG1573	uracil-dna glycosylase
H8F24_RS18695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8F24_RS18700	COG0793	Belongs to the peptidase S41A family
H8F24_RS18715	COG1269	ATP hydrolysis coupled proton transport
H8F24_RS18735	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
H8F24_RS18745	COG0668	transmembrane transport
H8F24_RS18750	COG1196	nuclear chromosome segregation
H8F24_RS18750	COG3264	Mechanosensitive ion channel
H8F24_RS18765	COG2124	cytochrome p450
H8F24_RS18785	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H8F24_RS18830	COG1230	cation diffusion facilitator family transporter
H8F24_RS18835	COG0300	oxidoreductase activity
H8F24_RS18850	COG0284	orotidine-5'-phosphate decarboxylase activity
H8F24_RS18850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8F24_RS18855	COG0418	dihydroorotase activity
H8F24_RS18865	COG0251	oxidation-reduction process
H8F24_RS18870	COG3842	ATPase activity
H8F24_RS18875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8F24_RS18880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8F24_RS18885	COG1132	(ABC) transporter
H8F24_RS18895	COG0456	acetyltransferase
H8F24_RS18900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain