locus-tag	class	description
H8F25_RS00010	COG0464	growth
H8F25_RS00025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F25_RS00030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F25_RS00040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F25_RS00065	COG4451	ribulose bisphosphate carboxylase, small
H8F25_RS00070	COG1850	ribulose-bisphosphate carboxylase activity
H8F25_RS00075	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F25_RS00090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8F25_RS00095	COG0123	including yeast histone deacetylase and acetoin utilization protein
H8F25_RS00100	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F25_RS00115	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F25_RS00125	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H8F25_RS00160	COG0095	Lipoate-protein ligase
H8F25_RS00165	COG0517	IMP dehydrogenase activity
H8F25_RS00165	COG1994	Peptidase M50
H8F25_RS00170	COG0135	phosphoribosylanthranilate isomerase activity
H8F25_RS00185	COG0825	malonyl-CoA metabolic process
H8F25_RS00190	COG5322	oxidoreductase activity
H8F25_RS00195	COG3396	Phenylacetate-CoA oxygenase
H8F25_RS00205	COG0539	negative regulation of cytoplasmic translation
H8F25_RS00225	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H8F25_RS00230	COG0308	aminopeptidase N
H8F25_RS00250	COG2205	protein histidine kinase activity
H8F25_RS00270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8F25_RS00275	COG3409	Peptidoglycan-binding domain 1 protein
H8F25_RS00275	COG3429	Glucose-6-phosphate dehydrogenase subunit
H8F25_RS00280	COG1797	cobyrinic acid a,c-diamide synthase activity
H8F25_RS00285	COG1254	Belongs to the acylphosphatase family
H8F25_RS00295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F25_RS00305	COG0142	geranyltranstransferase activity
H8F25_RS00310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8F25_RS00315	COG1480	7TM receptor with intracellular HD hydrolase
H8F25_RS00325	COG4095	Psort location CytoplasmicMembrane, score
H8F25_RS00350	COG0395	ABC-type sugar transport system, permease component
H8F25_RS00360	COG0406	alpha-ribazole phosphatase activity
H8F25_RS00375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8F25_RS00380	COG1543	Belongs to the glycosyl hydrolase 57 family
H8F25_RS00390	COG1126	abc transporter atp-binding protein
H8F25_RS00395	COG0765	amino acid transport
H8F25_RS00400	COG4597	amino acid ABC transporter
H8F25_RS00405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8F25_RS00410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8F25_RS00415	COG5001	Diguanylate cyclase
H8F25_RS00420	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8F25_RS00430	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F25_RS00435	COG3706	GGDEF domain
H8F25_RS00435	COG4251	negative regulation of phosphorylation
H8F25_RS00435	COG5001	Diguanylate cyclase
H8F25_RS00435	COG2203	Gaf domain
H8F25_RS00445	COG0784	Response regulator, receiver
H8F25_RS00445	COG4191	Histidine kinase
H8F25_RS00460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F25_RS00465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8F25_RS00475	COG0531	amino acid
H8F25_RS00480	COG0471	metal ion transport
H8F25_RS00480	COG3273	potassium ion transport
H8F25_RS00485	COG0586	Pfam SNARE associated Golgi protein
H8F25_RS00500	COG0418	dihydroorotase activity
H8F25_RS00530	COG1132	(ABC) transporter
H8F25_RS00550	COG0535	radical SAM domain protein
H8F25_RS00555	COG0281	malic enzyme
H8F25_RS00560	COG0284	orotidine-5'-phosphate decarboxylase activity
H8F25_RS00560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8F25_RS00590	COG3039	Transposase
H8F25_RS00595	COG1216	Glycosyl transferase, family 2
H8F25_RS00610	COG0438	transferase activity, transferring glycosyl groups
H8F25_RS00620	COG0561	phosphatase activity
H8F25_RS00620	COG3100	YcgL domain-containing protein
H8F25_RS00680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F25_RS00700	COG0674	pyruvate-flavodoxin oxidoreductase activity
H8F25_RS00700	COG1013	pyruvate-flavodoxin oxidoreductase activity
H8F25_RS00700	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H8F25_RS00700	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8F25_RS00705	COG0298	carbon dioxide binding
H8F25_RS00725	COG1902	pentaerythritol trinitrate reductase activity
H8F25_RS00740	COG0375	protein maturation
H8F25_RS00750	COG3259	Nickel-dependent hydrogenase
H8F25_RS00790	COG0159	tryptophan synthase activity
H8F25_RS00820	COG2010	Cytochrome c
H8F25_RS00850	COG3339	Conserved Protein
H8F25_RS00855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F25_RS00870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F25_RS00875	COG1121	(ABC) transporter
H8F25_RS00890	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8F25_RS00890	COG0140	phosphoribosyl-ATP diphosphatase activity
H8F25_RS00895	COG0720	synthase
H8F25_RS00905	COG0523	cobalamin synthesis protein
H8F25_RS00920	COG1840	ABC-type Fe3 transport system, periplasmic component
H8F25_RS00925	COG4176	ABC-type proline glycine betaine transport system permease component
H8F25_RS00930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F25_RS00935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8F25_RS00940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8F25_RS00965	COG1201	RNA secondary structure unwinding
H8F25_RS00990	COG0625	glutathione transferase activity
H8F25_RS01010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8F25_RS01025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8F25_RS01035	COG2197	response regulator
H8F25_RS01040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8F25_RS01045	COG0114	fumarate hydratase activity
H8F25_RS01055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8F25_RS01070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8F25_RS01085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8F25_RS01090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F25_RS01095	COG0473	3-isopropylmalate dehydrogenase activity
H8F25_RS01100	COG3954	Phosphoribulokinase
H8F25_RS01110	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8F25_RS01115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8F25_RS01125	COG0673	inositol 2-dehydrogenase activity
H8F25_RS01130	COG0191	fructose-bisphosphate aldolase activity
H8F25_RS01140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8F25_RS01145	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8F25_RS01190	COG0450	alkyl hydroperoxide reductase
H8F25_RS01195	COG0047	phosphoribosylformylglycinamidine synthase activity
H8F25_RS01200	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8F25_RS01225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8F25_RS01235	COG0129	dihydroxy-acid dehydratase activity
H8F25_RS01250	COG0363	glucosamine-6-phosphate deaminase activity
H8F25_RS01255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H8F25_RS01260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F25_RS01265	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8F25_RS01270	COG1494	fructose-1,6-bisphosphatase
H8F25_RS01275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H8F25_RS01285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8F25_RS01310	COG1217	gtp-binding protein TYPA
H8F25_RS01320	COG0644	oxidoreductase
H8F25_RS01325	COG0751	glycine-tRNA ligase activity
H8F25_RS01330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F25_RS01340	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8F25_RS01345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8F25_RS01355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8F25_RS01360	COG0052	Belongs to the universal ribosomal protein uS2 family
H8F25_RS01365	COG1216	Glycosyl transferase, family 2
H8F25_RS01375	COG1136	(ABC) transporter
H8F25_RS01415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8F25_RS01420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8F25_RS01425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8F25_RS01440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8F25_RS01450	COG0174	glutamine synthetase
H8F25_RS01470	COG0745	RESPONSE REGULATOR receiver
H8F25_RS01490	COG1132	(ABC) transporter
H8F25_RS01495	COG2274	protein secretion by the type I secretion system
H8F25_RS01500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8F25_RS01530	COG2442	InterPro IPR007367
H8F25_RS01565	COG0789	Transcriptional regulator
H8F25_RS01595	COG2217	Heavy metal translocating P-type atpase
H8F25_RS01650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F25_RS01765	COG0745	RESPONSE REGULATOR receiver
H8F25_RS01770	COG5002	protein histidine kinase activity
H8F25_RS01830	COG0464	growth
H8F25_RS01925	COG0582	viral genome integration into host DNA
H8F25_RS01945	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
H8F25_RS02115	COG3706	GGDEF domain
H8F25_RS02120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8F25_RS02125	COG4106	trans-aconitate 2-methyltransferase activity
H8F25_RS02130	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8F25_RS02145	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8F25_RS02150	COG1136	(ABC) transporter
H8F25_RS02170	COG1836	PFAM Integral membrane protein DUF92
H8F25_RS02185	COG0436	Aminotransferase
H8F25_RS02190	COG1573	uracil-dna glycosylase
H8F25_RS02195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8F25_RS02200	COG0793	Belongs to the peptidase S41A family
H8F25_RS02215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8F25_RS02225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F25_RS02245	COG0513	Belongs to the DEAD box helicase family
H8F25_RS02275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F25_RS02280	COG3119	arylsulfatase activity
H8F25_RS02320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8F25_RS02330	COG0312	modulator of DNA gyrase
H8F25_RS02335	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H8F25_RS02350	COG0163	prenyltransferase activity
H8F25_RS02355	COG0557	exoribonuclease II activity
H8F25_RS02380	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H8F25_RS02380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8F25_RS02385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8F25_RS02400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8F25_RS02405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F25_RS02435	COG2197	response regulator
H8F25_RS02445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H8F25_RS02450	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H8F25_RS02500	COG0347	Belongs to the P(II) protein family
H8F25_RS02505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8F25_RS02540	COG0515	serine threonine protein kinase
H8F25_RS02550	COG0628	permease
H8F25_RS02565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8F25_RS02570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8F25_RS02575	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8F25_RS02575	COG0022	dehydrogenase e1 component
H8F25_RS02585	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8F25_RS02590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8F25_RS02615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8F25_RS02640	COG2119	membrane
H8F25_RS02655	COG3706	GGDEF domain
H8F25_RS02685	COG0659	secondary active sulfate transmembrane transporter activity
H8F25_RS02695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H8F25_RS02705	COG3659	wide pore channel activity
H8F25_RS02710	COG1528	Iron-storage protein
H8F25_RS02730	COG0701	Predicted permease
H8F25_RS02735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F25_RS02740	COG5001	Diguanylate cyclase
H8F25_RS02805	COG2267	carboxylic ester hydrolase activity
H8F25_RS02875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8F25_RS02895	COG0076	glutamate decarboxylase activity
H8F25_RS02900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F25_RS02925	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8F25_RS02930	COG0271	Belongs to the BolA IbaG family
H8F25_RS02945	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8F25_RS02970	COG1074	ATP-dependent DNA helicase activity
H8F25_RS02975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F25_RS02980	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H8F25_RS02980	COG0662	Cupin 2, conserved barrel domain protein
H8F25_RS02985	COG0513	Belongs to the DEAD box helicase family
H8F25_RS03000	COG0724	RNA recognition motif
H8F25_RS03005	COG1132	(ABC) transporter
H8F25_RS03015	COG1285	pathogenesis
H8F25_RS03065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8F25_RS03075	COG4413	Urea transporter
H8F25_RS03080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8F25_RS03105	COG0475	glutathione-regulated potassium exporter activity
H8F25_RS03125	COG1741	Belongs to the pirin family
H8F25_RS03140	COG0724	RNA recognition motif
H8F25_RS03155	COG0778	Nitroreductase
H8F25_RS03180	COG1484	DNA-dependent DNA replication
H8F25_RS03225	COG3039	Transposase
H8F25_RS03230	COG3039	Transposase
H8F25_RS03245	COG2226	methyltransferase
H8F25_RS03275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F25_RS03300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8F25_RS03305	COG0149	triose-phosphate isomerase activity
H8F25_RS03310	COG2501	S4 domain
H8F25_RS03315	COG1132	(ABC) transporter
H8F25_RS03330	COG1122	ATPase activity
H8F25_RS03335	COG4120	Belongs to the binding-protein-dependent transport system permease family
H8F25_RS03350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8F25_RS03360	COG0799	negative regulation of ribosome biogenesis
H8F25_RS03415	COG3706	GGDEF domain
H8F25_RS03425	COG3588	fructose-bisphosphate aldolase
H8F25_RS03430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H8F25_RS03465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8F25_RS03475	COG0514	ATP-dependent DNA helicase (RecQ)
H8F25_RS03490	COG1175	transmembrane transport
H8F25_RS03495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H8F25_RS03525	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8F25_RS03540	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H8F25_RS03555	COG0740	serine-type endopeptidase activity
H8F25_RS03560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F25_RS03570	COG1136	(ABC) transporter
H8F25_RS03570	COG0577	efflux transmembrane transporter activity
H8F25_RS03575	COG0469	pyruvate kinase activity
H8F25_RS03600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8F25_RS03605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8F25_RS03645	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H8F25_RS03645	COG2066	Belongs to the glutaminase family
H8F25_RS03675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H8F25_RS03680	COG3842	ATPase activity
H8F25_RS03685	COG0395	ABC-type sugar transport system, permease component
H8F25_RS03695	COG1653	transport
H8F25_RS03715	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H8F25_RS03720	COG0483	inositol monophosphate 1-phosphatase activity
H8F25_RS03745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8F25_RS03750	COG0581	inorganic phosphate transmembrane transporter activity
H8F25_RS03755	COG0573	inorganic phosphate transmembrane transporter activity
H8F25_RS03765	COG0484	heat shock protein binding
H8F25_RS03775	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H8F25_RS03780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8F25_RS03785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F25_RS03790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8F25_RS03790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8F25_RS03795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8F25_RS03800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8F25_RS03825	COG0166	Belongs to the GPI family
H8F25_RS03835	COG0495	leucyl-tRNA aminoacylation
H8F25_RS03845	COG3039	Transposase
H8F25_RS03855	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8F25_RS03860	COG1104	cysteine desulfurase activity
H8F25_RS03875	COG2027	D-alanyl-D-alanine carboxypeptidase
H8F25_RS03885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8F25_RS03890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F25_RS03890	COG0426	domain, Protein
H8F25_RS03895	COG0322	excinuclease ABC activity
H8F25_RS03905	COG3046	protein related to deoxyribodipyrimidine photolyase
H8F25_RS03910	COG1981	membrane
H8F25_RS03930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8F25_RS03935	COG1410	methionine synthase
H8F25_RS03935	COG0646	methionine synthase
H8F25_RS03980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8F25_RS03990	COG2385	sporulation resulting in formation of a cellular spore
H8F25_RS04025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8F25_RS04030	COG0072	phenylalanine-tRNA ligase activity
H8F25_RS04035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H8F25_RS04040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8F25_RS04045	COG0557	exoribonuclease II activity
H8F25_RS04050	COG0445	tRNA wobble uridine modification
H8F25_RS04055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F25_RS04090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8F25_RS04095	COG0739	heme binding
H8F25_RS04145	COG0011	TIGRFAM Protein of
H8F25_RS04190	COG4191	Histidine kinase
H8F25_RS04190	COG0784	Response regulator, receiver
H8F25_RS04200	COG1484	DNA-dependent DNA replication
H8F25_RS04220	COG1525	nuclease
H8F25_RS04235	COG1819	glycosyl
H8F25_RS04250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F25_RS04265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8F25_RS04355	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H8F25_RS04385	COG3039	Transposase
H8F25_RS04410	COG1598	PFAM Uncharacterised protein family UPF0150
H8F25_RS04435	COG3447	MASE1 domain protein
H8F25_RS04435	COG5001	Diguanylate cyclase
H8F25_RS04435	COG5002	protein histidine kinase activity
H8F25_RS04535	COG3550	peptidyl-serine autophosphorylation
H8F25_RS04550	COG3328	transposase activity
H8F25_RS04590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F25_RS04605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F25_RS04620	COG1484	DNA-dependent DNA replication
H8F25_RS04650	COG3039	Transposase
H8F25_RS04665	COG2226	methyltransferase
H8F25_RS04725	COG0745	RESPONSE REGULATOR receiver
H8F25_RS04730	COG5002	protein histidine kinase activity
H8F25_RS04765	COG3039	Transposase
H8F25_RS04775	COG0723	plastoquinol--plastocyanin reductase activity
H8F25_RS04810	COG1294	oxidase, subunit
H8F25_RS04815	COG1271	oxidase subunit
H8F25_RS04850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8F25_RS04865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F25_RS04870	COG0842	Transport permease protein
H8F25_RS04870	COG1129	ABC transporter
H8F25_RS04880	COG0842	Transport permease protein
H8F25_RS04880	COG1129	ABC transporter
H8F25_RS04885	COG0842	Transport permease protein
H8F25_RS04915	COG0789	Transcriptional regulator
H8F25_RS04935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8F25_RS04955	COG5001	Diguanylate cyclase
H8F25_RS04955	COG3300	MHYT domain
H8F25_RS04965	COG5001	Diguanylate cyclase
H8F25_RS04970	COG0484	heat shock protein binding
H8F25_RS04980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F25_RS04995	COG3706	GGDEF domain
H8F25_RS05005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F25_RS05010	COG3039	Transposase
H8F25_RS05030	COG0358	DNA primase activity
H8F25_RS05050	COG0632	four-way junction helicase activity
H8F25_RS05055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8F25_RS05065	COG0587	DNA-directed DNA polymerase activity
H8F25_RS05070	COG0154	amidase activity
H8F25_RS05085	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H8F25_RS05095	COG0505	Belongs to the CarA family
H8F25_RS05100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8F25_RS05110	COG1132	(ABC) transporter
H8F25_RS05120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F25_RS05185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8F25_RS05200	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
H8F25_RS05215	COG1187	pseudouridine synthase activity
H8F25_RS05220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F25_RS05230	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F25_RS05235	COG1982	Orn Lys Arg decarboxylase major
H8F25_RS05240	COG2242	protein methyltransferase activity
H8F25_RS05240	COG2241	protein methyltransferase activity
H8F25_RS05245	COG0575	Belongs to the CDS family
H8F25_RS05265	COG0596	Alpha beta hydrolase
H8F25_RS05270	COG0371	Dehydrogenase
H8F25_RS05275	COG0542	response to heat
H8F25_RS05285	COG0019	diaminopimelate decarboxylase activity
H8F25_RS05290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H8F25_RS05295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8F25_RS05300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8F25_RS05305	COG1054	Belongs to the UPF0176 family
H8F25_RS05340	COG0475	glutathione-regulated potassium exporter activity
H8F25_RS05350	COG0651	ATP synthesis coupled electron transport
H8F25_RS05380	COG0659	secondary active sulfate transmembrane transporter activity
H8F25_RS05395	COG0347	Belongs to the P(II) protein family
H8F25_RS05405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F25_RS05415	COG0076	glutamate decarboxylase activity
H8F25_RS05445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8F25_RS05465	COG0574	Belongs to the PEP-utilizing enzyme family
H8F25_RS05465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8F25_RS05480	COG0028	Belongs to the TPP enzyme family
H8F25_RS05490	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F25_RS05505	COG0528	UMP kinase activity
H8F25_RS05510	COG0233	cytoplasmic translational termination
H8F25_RS05525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8F25_RS05530	COG0768	penicillin binding
H8F25_RS05550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8F25_RS05585	COG0442	prolyl-tRNA aminoacylation
H8F25_RS05595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8F25_RS05600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F25_RS05605	COG2099	Precorrin-6x reductase
H8F25_RS05610	COG0629	single-stranded DNA binding
H8F25_RS05625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8F25_RS05635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8F25_RS05640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F25_RS05665	COG0181	hydroxymethylbilane synthase activity
H8F25_RS05680	COG1376	ErfK ybiS ycfS ynhG family protein
H8F25_RS05690	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H8F25_RS05740	COG0745	RESPONSE REGULATOR receiver
H8F25_RS05745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8F25_RS05750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8F25_RS05755	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8F25_RS05765	COG0196	riboflavin kinase activity
H8F25_RS05790	COG1691	(AIR) carboxylase
H8F25_RS05800	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8F25_RS05815	COG0336	Belongs to the RNA methyltransferase TrmD family
H8F25_RS05855	COG0489	protein tyrosine kinase activity
H8F25_RS05885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F25_RS05905	COG0297	glycogen (starch) synthase activity
H8F25_RS05910	COG1132	(ABC) transporter
H8F25_RS05925	COG0438	transferase activity, transferring glycosyl groups
H8F25_RS05935	COG3039	Transposase
H8F25_RS05965	COG1215	transferase activity, transferring glycosyl groups
H8F25_RS05975	COG1216	Glycosyl transferase, family 2
H8F25_RS05980	COG0438	transferase activity, transferring glycosyl groups
H8F25_RS05990	COG1215	transferase activity, transferring glycosyl groups
H8F25_RS06080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8F25_RS06085	COG3039	Transposase
H8F25_RS06110	COG0438	transferase activity, transferring glycosyl groups
H8F25_RS06150	COG3039	Transposase
H8F25_RS06160	COG3039	Transposase
H8F25_RS06185	COG1132	(ABC) transporter
H8F25_RS06205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8F25_RS06255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8F25_RS06260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F25_RS06265	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H8F25_RS06275	COG0670	Belongs to the BI1 family
H8F25_RS06280	COG1702	phosphate starvation-inducible protein PhoH
H8F25_RS06295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8F25_RS06305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8F25_RS06310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F25_RS06315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8F25_RS06315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8F25_RS06320	COG0482	sulfurtransferase activity
H8F25_RS06325	COG1492	cobalamin metabolic process
H8F25_RS06340	COG0424	maF-like protein
H8F25_RS06360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F25_RS06365	COG0440	acetolactate synthase activity
H8F25_RS06400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H8F25_RS06405	COG0492	ferredoxin-NADP+ reductase activity
H8F25_RS06455	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8F25_RS06485	COG0215	cysteine-tRNA ligase activity
H8F25_RS06495	COG1088	dTDP-glucose 4,6-dehydratase activity
H8F25_RS06515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F25_RS06515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F25_RS06540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8F25_RS06565	COG0335	large ribosomal subunit rRNA binding
H8F25_RS06575	COG0024	Methionine aminopeptidase
H8F25_RS06580	COG0300	oxidoreductase activity
H8F25_RS06580	COG3000	fatty acid hydroxylase
H8F25_RS06585	COG0857	belongs to the CobB CobQ family
H8F25_RS06600	COG0330	HflC and HflK could
H8F25_RS06610	COG1666	GTP binding
H8F25_RS06640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8F25_RS06760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8F25_RS06765	COG0277	FAD linked oxidase domain protein
H8F25_RS06770	COG0730	response to heat
H8F25_RS06785	COG1959	2 iron, 2 sulfur cluster binding
H8F25_RS06805	COG3039	Transposase
H8F25_RS06810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F25_RS06810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F25_RS06815	COG0668	transmembrane transport
H8F25_RS06830	COG2135	peptidase activity
H8F25_RS06835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F25_RS06840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8F25_RS06845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8F25_RS06880	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8F25_RS06905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H8F25_RS06920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8F25_RS06935	COG0415	Belongs to the DNA photolyase family
H8F25_RS06940	COG0765	amino acid transport
H8F25_RS06955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8F25_RS06995	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H8F25_RS07030	COG1322	Protein conserved in bacteria
H8F25_RS07075	COG1022	Amp-dependent synthetase and ligase
H8F25_RS07080	COG0321	lipoyl(octanoyl) transferase activity
H8F25_RS07085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8F25_RS07090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H8F25_RS07095	COG1381	Involved in DNA repair and RecF pathway recombination
H8F25_RS07105	COG0438	transferase activity, transferring glycosyl groups
H8F25_RS07125	COG0697	spore germination
H8F25_RS07130	COG0616	signal peptide processing
H8F25_RS07145	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H8F25_RS07150	COG0594	ribonuclease P activity
H8F25_RS07160	COG0706	membrane insertase activity
H8F25_RS07170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F25_RS07180	COG1523	belongs to the glycosyl hydrolase 13 family
H8F25_RS07190	COG0776	regulation of translation
H8F25_RS07205	COG1028	Short-chain dehydrogenase reductase Sdr
H8F25_RS07255	COG0640	Transcriptional regulator
H8F25_RS07260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F25_RS07285	COG5001	Diguanylate cyclase
H8F25_RS07305	COG3039	Transposase
H8F25_RS07325	COG0477	Major facilitator Superfamily
H8F25_RS07330	COG5001	Diguanylate cyclase
H8F25_RS07330	COG3706	GGDEF domain
H8F25_RS07330	COG4251	negative regulation of phosphorylation
H8F25_RS07330	COG2203	Gaf domain
H8F25_RS07350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8F25_RS07360	COG0195	Participates in both transcription termination and antitermination
H8F25_RS07365	COG0779	Required for maturation of 30S ribosomal subunits
H8F25_RS07375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H8F25_RS07380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F25_RS07385	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8F25_RS07390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F25_RS07400	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H8F25_RS07405	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H8F25_RS07420	COG0443	Heat shock 70 kDa protein
H8F25_RS07440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8F25_RS07460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8F25_RS07465	COG2264	protein methyltransferase activity
H8F25_RS07480	COG2010	Cytochrome c
H8F25_RS07485	COG1234	tRNA 3'-trailer cleavage
H8F25_RS07490	COG2247	cell wall binding repeat
H8F25_RS07490	COG2385	sporulation resulting in formation of a cellular spore
H8F25_RS07495	COG0363	glucosamine-6-phosphate deaminase activity
H8F25_RS07500	COG0217	transcriptional regulatory protein
H8F25_RS07505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8F25_RS07510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8F25_RS07515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8F25_RS07530	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8F25_RS07535	COG5002	protein histidine kinase activity
H8F25_RS07540	COG0151	Belongs to the GarS family
H8F25_RS07560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8F25_RS07565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8F25_RS07570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F25_RS07580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F25_RS07595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8F25_RS07615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8F25_RS07635	COG0284	orotidine-5'-phosphate decarboxylase activity
H8F25_RS07645	COG1231	oxidoreductase activity
H8F25_RS07665	COG1842	Phage shock protein A
H8F25_RS07670	COG3118	belongs to the thioredoxin family
H8F25_RS07675	COG0436	Aminotransferase
H8F25_RS07685	COG0739	heme binding
H8F25_RS07690	COG1136	(ABC) transporter
H8F25_RS07695	COG1007	ATP synthesis coupled electron transport
H8F25_RS07700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8F25_RS07715	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8F25_RS07750	COG1845	cytochrome c oxidase, subunit III
H8F25_RS07755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8F25_RS07770	COG0109	protoheme IX farnesyltransferase activity
H8F25_RS07790	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H8F25_RS07800	COG0459	protein refolding
H8F25_RS07810	COG1028	Short-chain dehydrogenase reductase Sdr
H8F25_RS07825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8F25_RS07840	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F25_RS07860	COG0351	phosphomethylpyrimidine kinase
H8F25_RS07865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F25_RS07920	COG0579	oxidoreductase
H8F25_RS07945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8F25_RS07950	COG0739	heme binding
H8F25_RS07955	COG0723	plastoquinol--plastocyanin reductase activity
H8F25_RS07970	COG0805	protein transport
H8F25_RS07980	COG0194	GDP metabolic process
H8F25_RS07995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8F25_RS08000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F25_RS08015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F25_RS08020	COG0012	GTP binding
H8F25_RS08050	COG0601	transmembrane transport
H8F25_RS08065	COG0460	homoserine dehydrogenase
H8F25_RS08070	COG2166	iron-sulfur cluster assembly
H8F25_RS08085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8F25_RS08090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8F25_RS08105	COG0402	S-adenosylhomocysteine deaminase activity
H8F25_RS08120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8F25_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
H8F25_RS08140	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F25_RS08155	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H8F25_RS08160	COG2010	Cytochrome c
H8F25_RS08175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8F25_RS08180	COG1611	Belongs to the LOG family
H8F25_RS08185	COG3118	belongs to the thioredoxin family
H8F25_RS08190	COG0516	GMP reductase activity
H8F25_RS08195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8F25_RS08205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8F25_RS08210	COG2226	methyltransferase
H8F25_RS08230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F25_RS08235	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8F25_RS08245	COG0740	serine-type endopeptidase activity
H8F25_RS08250	COG0740	serine-type endopeptidase activity
H8F25_RS08260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8F25_RS08265	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8F25_RS08275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H8F25_RS08290	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8F25_RS08295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F25_RS08300	COG2066	Belongs to the glutaminase family
H8F25_RS08300	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H8F25_RS08305	COG4948	Mandelate Racemase Muconate Lactonizing
H8F25_RS08340	COG0285	dihydrofolate synthase activity
H8F25_RS08345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8F25_RS08350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8F25_RS08355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8F25_RS08370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F25_RS08375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F25_RS08380	COG0134	indole-3-glycerol-phosphate synthase activity
H8F25_RS08395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H8F25_RS08400	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8F25_RS08410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8F25_RS08415	COG1104	cysteine desulfurase activity
H8F25_RS08430	COG3039	Transposase
H8F25_RS08450	COG1132	(ABC) transporter
H8F25_RS08460	COG0438	transferase activity, transferring glycosyl groups
H8F25_RS08470	COG1216	Glycosyl transferase, family 2
H8F25_RS08470	COG0463	Glycosyl transferase, family 2
H8F25_RS08540	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H8F25_RS08545	COG1218	3'(2'),5'-bisphosphate nucleotidase
H8F25_RS08550	COG2124	cytochrome p450
H8F25_RS08565	COG1185	polyribonucleotide nucleotidyltransferase activity
H8F25_RS08575	COG0750	zinc metalloprotease
H8F25_RS08580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8F25_RS08605	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8F25_RS08635	COG3039	Transposase
H8F25_RS08675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8F25_RS08690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8F25_RS08705	COG0582	viral genome integration into host DNA
H8F25_RS08735	COG3039	Transposase
H8F25_RS08755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F25_RS08770	COG0148	phosphopyruvate hydratase activity
H8F25_RS08780	COG0542	response to heat
H8F25_RS08785	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8F25_RS08790	COG0250	Participates in transcription elongation, termination and antitermination
H8F25_RS08795	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8F25_RS08800	COG0081	regulation of translation
H8F25_RS08805	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8F25_RS08810	COG0222	ribosome binding
H8F25_RS08830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8F25_RS08850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F25_RS08865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F25_RS08865	COG0426	domain, Protein
H8F25_RS08870	COG0426	domain, Protein
H8F25_RS08870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F25_RS08890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8F25_RS08890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8F25_RS08895	COG0509	glycine decarboxylation via glycine cleavage system
H8F25_RS08915	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H8F25_RS08940	COG0359	binds to the 23S rRNA
H8F25_RS08945	COG1372	Participates in initiation and elongation during chromosome replication
H8F25_RS08945	COG0305	Participates in initiation and elongation during chromosome replication
H8F25_RS08945	COG1372	Participates in initiation and elongation during chromosome replication
H8F25_RS08945	COG0305	Participates in initiation and elongation during chromosome replication
H8F25_RS08950	COG0445	tRNA wobble uridine modification
H8F25_RS08990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F25_RS09005	COG0577	efflux transmembrane transporter activity
H8F25_RS09005	COG1136	(ABC) transporter
H8F25_RS09010	COG0598	Magnesium transport protein CorA
H8F25_RS09025	COG0398	Pfam SNARE associated Golgi protein
H8F25_RS09070	COG3706	GGDEF domain
H8F25_RS09070	COG5001	Diguanylate cyclase
H8F25_RS09070	COG2203	Gaf domain
H8F25_RS09070	COG4251	negative regulation of phosphorylation
H8F25_RS09075	COG0525	valine-tRNA ligase activity
H8F25_RS09080	COG5001	Diguanylate cyclase
H8F25_RS09080	COG5002	protein histidine kinase activity
H8F25_RS09115	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H8F25_RS09115	COG3264	Mechanosensitive ion channel
H8F25_RS09125	COG2326	polyphosphate kinase activity
H8F25_RS09130	COG5001	Diguanylate cyclase
H8F25_RS09130	COG3300	MHYT domain
H8F25_RS09155	COG0464	growth
H8F25_RS09175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F25_RS09200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F25_RS09210	COG1111	helicase
H8F25_RS09210	COG1205	dead DEAH box helicase
H8F25_RS09215	COG0210	DNA helicase
H8F25_RS09315	COG3956	TIGRFAM MazG family protein
H8F25_RS09320	COG0288	reversible hydration of carbon dioxide
H8F25_RS09330	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H8F25_RS09335	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8F25_RS09340	COG0010	Belongs to the arginase family
H8F25_RS09355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8F25_RS09360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8F25_RS09365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F25_RS09370	COG1598	PFAM Uncharacterised protein family UPF0150
H8F25_RS09430	COG3039	Transposase
H8F25_RS09485	COG0010	Belongs to the arginase family
H8F25_RS09490	COG0375	protein maturation
H8F25_RS09505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8F25_RS09510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8F25_RS09515	COG1116	anion transmembrane transporter activity
H8F25_RS09535	COG0783	Belongs to the Dps family
H8F25_RS09570	COG0602	queuosine metabolic process
H8F25_RS09585	COG0602	queuosine metabolic process
H8F25_RS09600	COG4574	serine-type endopeptidase inhibitor activity
H8F25_RS09605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8F25_RS09615	COG0823	Involved in the tonB-independent uptake of proteins
H8F25_RS09615	COG1506	peptidase
H8F25_RS09640	COG0411	ABC transporter
H8F25_RS09645	COG1172	Belongs to the binding-protein-dependent transport system permease family
H8F25_RS09660	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H8F25_RS09665	COG0830	nickel cation binding
H8F25_RS09670	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H8F25_RS09675	COG0829	nickel cation binding
H8F25_RS09680	COG0831	urea catabolic process
H8F25_RS09685	COG0832	Belongs to the urease beta subunit family
H8F25_RS09690	COG0804	urea catabolic process
H8F25_RS09700	COG2308	Evidence 4 Homologs of previously reported genes of
H8F25_RS09715	COG0058	SHG alpha-glucan phosphorylase activity
H8F25_RS09725	COG3706	GGDEF domain
H8F25_RS09745	COG3437	response regulator, receiver
H8F25_RS09760	COG3321	synthase
H8F25_RS09760	COG0604	alcohol dehydrogenase
H8F25_RS09760	COG0604	alcohol dehydrogenase
H8F25_RS09760	COG3321	synthase
H8F25_RS09760	COG1028	Short-chain dehydrogenase reductase Sdr
H8F25_RS09760	COG1028	Short-chain dehydrogenase reductase Sdr
H8F25_RS09770	COG3039	Transposase
H8F25_RS09775	COG0604	alcohol dehydrogenase
H8F25_RS09775	COG3321	synthase
H8F25_RS09780	COG1136	(ABC) transporter
H8F25_RS09825	COG3706	GGDEF domain
H8F25_RS09845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8F25_RS09845	COG1648	precorrin-2 dehydrogenase activity
H8F25_RS09850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F25_RS09880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H8F25_RS09895	COG0628	permease
H8F25_RS09905	COG0529	Catalyzes the synthesis of activated sulfate
H8F25_RS09910	COG0750	zinc metalloprotease
H8F25_RS09920	COG0023	Translation Initiation Factor
H8F25_RS09940	COG0133	tryptophan synthase activity
H8F25_RS09950	COG1420	regulation of RNA biosynthetic process
H8F25_RS09955	COG1054	Belongs to the UPF0176 family
H8F25_RS09965	COG2062	phosphohistidine phosphatase, SixA
H8F25_RS09970	COG0372	Belongs to the citrate synthase family
H8F25_RS09975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8F25_RS09980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F25_RS09985	COG0839	Belongs to the complex I subunit 6 family
H8F25_RS09990	COG0713	ATP synthesis coupled electron transport
H8F25_RS09995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8F25_RS10010	COG2197	response regulator
H8F25_RS10020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8F25_RS10035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F25_RS10055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F25_RS10065	COG0583	DNA-binding transcription factor activity
H8F25_RS10110	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H8F25_RS10110	COG0493	'glutamate synthase
H8F25_RS10115	COG1562	ergosterol biosynthetic process
H8F25_RS10130	COG0617	tRNA 3'-terminal CCA addition
H8F25_RS10155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8F25_RS10160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8F25_RS10165	COG0416	fatty acid biosynthetic process
H8F25_RS10170	COG0745	RESPONSE REGULATOR receiver
H8F25_RS10175	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H8F25_RS10180	COG3063	Type IV pilus biogenesis stability protein PilW
H8F25_RS10185	COG2217	Heavy metal translocating P-type atpase
H8F25_RS10190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8F25_RS10200	COG0745	RESPONSE REGULATOR receiver
H8F25_RS10210	COG1122	ATPase activity
H8F25_RS10230	COG3659	wide pore channel activity
H8F25_RS10235	COG3659	wide pore channel activity
H8F25_RS10315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H8F25_RS10320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H8F25_RS10325	COG2226	methyltransferase
H8F25_RS10335	COG1090	epimerase
H8F25_RS10355	COG0316	Belongs to the HesB IscA family
H8F25_RS10360	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H8F25_RS10375	COG1587	Uroporphyrinogen-III synthase
H8F25_RS10385	COG1472	Belongs to the glycosyl hydrolase 3 family
H8F25_RS10390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8F25_RS10415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8F25_RS10450	COG1032	radical SAM domain protein
H8F25_RS10465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F25_RS10470	COG4243	Vitamin k epoxide reductase
H8F25_RS10475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H8F25_RS10480	COG1555	photosystem II stabilization
H8F25_RS10490	COG1968	undecaprenyl-diphosphatase activity
H8F25_RS10550	COG2144	transferase activity, transferring acyl groups
H8F25_RS10575	COG2072	flavoprotein involved in K transport
H8F25_RS10580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8F25_RS10585	COG0459	protein refolding
H8F25_RS10590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H8F25_RS10595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8F25_RS10600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8F25_RS10620	COG1402	creatininase
H8F25_RS10625	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8F25_RS10650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8F25_RS10655	COG1716	ATPase activity
H8F25_RS10655	COG5001	Diguanylate cyclase
H8F25_RS10695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8F25_RS10710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8F25_RS10735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8F25_RS10750	COG0484	heat shock protein binding
H8F25_RS10760	COG0113	porphobilinogen synthase activity
H8F25_RS10780	COG1193	negative regulation of DNA recombination
H8F25_RS10785	COG3842	ATPase activity
H8F25_RS10790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8F25_RS10805	COG0488	(ABC) transporter
H8F25_RS10820	COG2988	succinylglutamate desuccinylase activity
H8F25_RS10835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8F25_RS10840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8F25_RS10880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F25_RS10900	COG3536	Protein conserved in bacteria
H8F25_RS10910	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F25_RS10925	COG0540	Belongs to the ATCase OTCase family
H8F25_RS10930	COG2094	Belongs to the DNA glycosylase MPG family
H8F25_RS10950	COG4115	mRNA cleavage
H8F25_RS10955	COG2161	toxin-antitoxin pair type II binding
H8F25_RS10985	COG2205	protein histidine kinase activity
H8F25_RS10990	COG0745	RESPONSE REGULATOR receiver
H8F25_RS11020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F25_RS11030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F25_RS11030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8F25_RS11035	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8F25_RS11040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F25_RS11050	COG0107	imidazoleglycerol-phosphate synthase activity
H8F25_RS11060	COG2226	methyltransferase
H8F25_RS11065	COG0752	glycyl-tRNA synthetase alpha subunit
H8F25_RS11080	COG3039	Transposase
H8F25_RS11095	COG0367	asparagine synthase
H8F25_RS11100	COG0540	Belongs to the ATCase OTCase family
H8F25_RS11115	COG0659	secondary active sulfate transmembrane transporter activity
H8F25_RS11140	COG4221	oxidoreductase activity
H8F25_RS11175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8F25_RS11190	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8F25_RS11215	COG1111	helicase
H8F25_RS11215	COG1205	dead DEAH box helicase
H8F25_RS11235	COG3039	Transposase
H8F25_RS11260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H8F25_RS11275	COG4260	virion core protein, lumpy skin disease virus
H8F25_RS11295	COG0237	dephospho-CoA kinase activity
H8F25_RS11300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8F25_RS11305	COG2022	thiamine diphosphate biosynthetic process
H8F25_RS11305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F25_RS11310	COG4067	protein conserved in archaea
H8F25_RS11310	COG0189	ligase activity
H8F25_RS11335	COG1803	Methylglyoxal synthase
H8F25_RS11340	COG0105	UTP biosynthetic process
H8F25_RS11365	COG2161	toxin-antitoxin pair type II binding
H8F25_RS11390	COG1166	arginine decarboxylase activity
H8F25_RS11405	COG0328	RNA-DNA hybrid ribonuclease activity
H8F25_RS11410	COG0167	dihydroorotate dehydrogenase activity
H8F25_RS11430	COG4796	Type ii and iii secretion system protein
H8F25_RS11460	COG0714	Associated with various cellular activities
H8F25_RS11470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8F25_RS11515	COG0126	phosphoglycerate kinase activity
H8F25_RS11520	COG0589	response to stress
H8F25_RS11530	COG0564	pseudouridine synthase activity
H8F25_RS11575	COG4172	Belongs to the ABC transporter superfamily
H8F25_RS11580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8F25_RS11625	COG0157	Belongs to the NadC ModD family
H8F25_RS11640	COG0641	radical SAM
H8F25_RS11645	COG0242	peptide deformylase activity
H8F25_RS11655	COG0018	arginyl-trna synthetase
H8F25_RS11665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F25_RS11680	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8F25_RS11685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8F25_RS11710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8F25_RS11715	COG0189	ligase activity
H8F25_RS11730	COG1575	Belongs to the MenA family. Type 1 subfamily
H8F25_RS11800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F25_RS11815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8F25_RS11820	COG0511	ligase activity, forming carbon-carbon bonds
H8F25_RS11825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8F25_RS11830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F25_RS11835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8F25_RS11855	COG0463	Glycosyl transferase, family 2
H8F25_RS11880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F25_RS11885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8F25_RS11890	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8F25_RS11895	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8F25_RS11900	COG1162	GTPase activity
H8F25_RS11910	COG0484	heat shock protein binding
H8F25_RS11915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8F25_RS11920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8F25_RS11930	COG1459	type II secretion system
H8F25_RS11935	COG2081	HI0933 family
H8F25_RS11940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F25_RS11945	COG0724	RNA recognition motif
H8F25_RS11950	COG0165	Argininosuccinate lyase
H8F25_RS11955	COG2208	phosphoserine phosphatase activity
H8F25_RS11960	COG0552	protein localization to endoplasmic reticulum
H8F25_RS11965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F25_RS11980	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8F25_RS11990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8F25_RS11995	COG0438	transferase activity, transferring glycosyl groups
H8F25_RS12000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H8F25_RS12005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8F25_RS12015	COG0592	DNA-directed DNA polymerase activity
H8F25_RS12020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8F25_RS12030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F25_RS12050	COG0037	tRNA processing
H8F25_RS12060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H8F25_RS12065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8F25_RS12070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8F25_RS12075	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8F25_RS12080	COG0740	serine-type endopeptidase activity
H8F25_RS12085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8F25_RS12095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H8F25_RS12100	COG1215	transferase activity, transferring glycosyl groups
H8F25_RS12105	COG2385	sporulation resulting in formation of a cellular spore
H8F25_RS12110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H8F25_RS12115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H8F25_RS12130	COG2022	thiamine diphosphate biosynthetic process
H8F25_RS12150	COG0768	penicillin binding
H8F25_RS12165	COG0519	Catalyzes the synthesis of GMP from XMP
H8F25_RS12165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8F25_RS12170	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
H8F25_RS12190	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8F25_RS12200	COG0673	inositol 2-dehydrogenase activity
H8F25_RS12225	COG2072	flavoprotein involved in K transport
H8F25_RS12235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H8F25_RS12250	COG0673	inositol 2-dehydrogenase activity
H8F25_RS12275	COG0438	transferase activity, transferring glycosyl groups
H8F25_RS12280	COG0649	NAD binding
H8F25_RS12320	COG0745	RESPONSE REGULATOR receiver
H8F25_RS12325	COG0564	pseudouridine synthase activity
H8F25_RS12335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8F25_RS12360	COG5001	Diguanylate cyclase
H8F25_RS12360	COG3300	MHYT domain
H8F25_RS12365	COG1053	succinate dehydrogenase
H8F25_RS12385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8F25_RS12390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F25_RS12395	COG0170	dolichyl monophosphate biosynthetic process
H8F25_RS12410	COG1335	isochorismatase
H8F25_RS12415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8F25_RS12425	COG1049	propionate catabolic process, 2-methylcitrate cycle
H8F25_RS12450	COG0788	formyltetrahydrofolate deformylase activity
H8F25_RS12460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F25_RS12465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8F25_RS12470	COG0443	Heat shock 70 kDa protein
H8F25_RS12475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F25_RS12495	COG0137	argininosuccinate synthase activity
H8F25_RS12510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F25_RS12525	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8F25_RS12540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8F25_RS12555	COG0497	DNA recombination
H8F25_RS12580	COG2082	Precorrin-8x methylmutase
H8F25_RS12590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8F25_RS12600	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8F25_RS12605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F25_RS12675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8F25_RS12685	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H8F25_RS12735	COG0653	protein targeting
H8F25_RS12750	COG1045	serine acetyltransferase
H8F25_RS12755	COG1725	Transcriptional regulator
H8F25_RS12760	COG0412	Dienelactone hydrolase
H8F25_RS12770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8F25_RS12775	COG0187	DNA topoisomerase II activity
H8F25_RS12775	COG1372	Participates in initiation and elongation during chromosome replication
H8F25_RS12785	COG0386	Belongs to the glutathione peroxidase family
H8F25_RS12790	COG2239	Acts as a magnesium transporter
H8F25_RS12795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F25_RS12830	COG0802	atpase or kinase
H8F25_RS12840	COG0586	Pfam SNARE associated Golgi protein
H8F25_RS12845	COG0629	single-stranded DNA binding
H8F25_RS12850	COG1077	Cell shape determining protein MreB Mrl
H8F25_RS12875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8F25_RS12890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8F25_RS12910	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H8F25_RS12915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F25_RS12925	COG0515	serine threonine protein kinase
H8F25_RS12930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8F25_RS12935	COG2255	four-way junction helicase activity
H8F25_RS12945	COG1473	amidohydrolase
H8F25_RS12960	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8F25_RS12965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8F25_RS12970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8F25_RS12975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8F25_RS12980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F25_RS12985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8F25_RS12995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8F25_RS13005	COG0571	ribonuclease III activity
H8F25_RS13040	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H8F25_RS13135	COG3039	Transposase
H8F25_RS13180	COG3039	Transposase
H8F25_RS13250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F25_RS13275	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H8F25_RS13295	COG1487	ribonuclease activity
H8F25_RS13380	COG0058	SHG alpha-glucan phosphorylase activity
H8F25_RS13385	COG0475	glutathione-regulated potassium exporter activity
H8F25_RS13400	COG2755	lipolytic protein G-D-S-L family
H8F25_RS13400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8F25_RS13405	COG0277	FAD linked oxidase domain protein
H8F25_RS13420	COG0247	lactate metabolic process
H8F25_RS13435	COG0538	isocitrate dehydrogenase activity
H8F25_RS13450	COG5398	heme oxygenase
H8F25_RS13470	COG1132	(ABC) transporter
H8F25_RS13495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8F25_RS13495	COG2755	lipolytic protein G-D-S-L family
H8F25_RS13500	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8F25_RS13510	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8F25_RS13545	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H8F25_RS13565	COG0617	tRNA 3'-terminal CCA addition
H8F25_RS13575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8F25_RS13585	COG0124	histidyl-tRNA synthetase
H8F25_RS13610	COG4447	cellulose binding
H8F25_RS13615	COG1773	rubredoxin
H8F25_RS13620	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F25_RS13625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F25_RS13635	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H8F25_RS13640	COG3842	ATPase activity
H8F25_RS13655	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F25_RS13655	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F25_RS13660	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8F25_RS13670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8F25_RS13675	COG0494	nUDIX hydrolase
H8F25_RS13680	COG0415	Belongs to the DNA photolyase family
H8F25_RS13700	COG2226	methyltransferase
H8F25_RS13710	COG0415	Belongs to the DNA photolyase family
H8F25_RS13725	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8F25_RS13740	COG2072	flavoprotein involved in K transport
H8F25_RS13755	COG0318	PFAM AMP-dependent synthetase and ligase
H8F25_RS13760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8F25_RS13775	COG0131	Imidazoleglycerol-phosphate dehydratase
H8F25_RS13790	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H8F25_RS13815	COG1487	ribonuclease activity
H8F25_RS13825	COG1073	alpha beta
H8F25_RS13830	COG0242	peptide deformylase activity
H8F25_RS13845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H8F25_RS13860	COG0537	adenosine 5'-monophosphoramidase activity
H8F25_RS13865	COG4178	(ABC) transporter
H8F25_RS13870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F25_RS13885	COG0515	serine threonine protein kinase
H8F25_RS13900	COG0439	Biotin carboxylase
H8F25_RS13910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F25_RS13915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F25_RS13925	COG1196	nuclear chromosome segregation
H8F25_RS13940	COG0116	Belongs to the methyltransferase superfamily
H8F25_RS13950	COG0393	Putative heavy-metal-binding
H8F25_RS13955	COG0717	Belongs to the dCTP deaminase family
H8F25_RS13965	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8F25_RS13970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F25_RS13975	COG4372	Transposase
H8F25_RS13990	COG0193	aminoacyl-tRNA hydrolase activity
H8F25_RS13995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8F25_RS14025	COG0066	3-isopropylmalate dehydratase activity
H8F25_RS14040	COG1058	Belongs to the CinA family
H8F25_RS14040	COG1546	Belongs to the CinA family
H8F25_RS14045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F25_RS14050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8F25_RS14075	COG0728	peptidoglycan biosynthetic process
H8F25_RS14080	COG1489	DNA binding
H8F25_RS14085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8F25_RS14100	COG0138	bifunctional purine biosynthesis protein purh
H8F25_RS14125	COG0343	queuine tRNA-ribosyltransferase activity
H8F25_RS14155	COG0673	inositol 2-dehydrogenase activity
H8F25_RS14160	COG1253	flavin adenine dinucleotide binding
H8F25_RS14165	COG1051	belongs to the nudix hydrolase family
H8F25_RS14205	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8F25_RS14210	COG0235	Class ii aldolase
H8F25_RS14215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8F25_RS14230	COG0514	ATP-dependent DNA helicase (RecQ)
H8F25_RS14240	COG1012	belongs to the aldehyde dehydrogenase family
H8F25_RS14265	COG5001	Diguanylate cyclase
H8F25_RS14310	COG3039	Transposase
H8F25_RS14315	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F25_RS14325	COG3093	addiction module antidote protein HigA
H8F25_RS14350	COG4804	nuclease activity
H8F25_RS14355	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H8F25_RS14390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8F25_RS14410	COG2203	Gaf domain
H8F25_RS14410	COG5001	Diguanylate cyclase
H8F25_RS14410	COG3706	GGDEF domain
H8F25_RS14410	COG4251	negative regulation of phosphorylation
H8F25_RS14430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F25_RS14440	COG1160	GTP binding
H8F25_RS14445	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H8F25_RS14455	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8F25_RS14460	COG1799	cell septum assembly
H8F25_RS14465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8F25_RS14470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H8F25_RS14485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8F25_RS14490	COG2211	Major facilitator Superfamily
H8F25_RS14515	COG3311	Transcriptional regulator
H8F25_RS14550	COG1201	RNA secondary structure unwinding
H8F25_RS14595	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H8F25_RS14600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F25_RS14635	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8F25_RS14660	COG0436	Aminotransferase
H8F25_RS14675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8F25_RS14685	COG1605	Chorismate mutase
H8F25_RS14685	COG0077	Prephenate dehydratase
H8F25_RS14690	COG2226	methyltransferase
H8F25_RS14700	COG0051	transcription antitermination factor activity, RNA binding
H8F25_RS14705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8F25_RS14715	COG0049	tRNA binding
H8F25_RS14720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8F25_RS14735	COG0070	glutamate synthase
H8F25_RS14735	COG0069	glutamate synthase activity
H8F25_RS14735	COG0067	glutamate synthase
H8F25_RS14745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8F25_RS14765	COG2885	chlorophyll binding
H8F25_RS14770	COG2885	chlorophyll binding
H8F25_RS14795	COG0463	Glycosyl transferase, family 2
H8F25_RS14815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8F25_RS14825	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8F25_RS14830	COG0254	rRNA binding
H8F25_RS14835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8F25_RS14840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H8F25_RS14845	COG0101	tRNA pseudouridine synthase activity
H8F25_RS14850	COG0203	ribosomal protein L17
H8F25_RS14855	COG0202	RNA polymerase activity
H8F25_RS14860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H8F25_RS14865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H8F25_RS14870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H8F25_RS14875	COG0563	adenylate kinase activity
H8F25_RS14880	COG0201	protein transport
H8F25_RS14885	COG0200	Binds to the 23S rRNA
H8F25_RS14890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H8F25_RS14895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8F25_RS14900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8F25_RS14905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8F25_RS14910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8F25_RS14915	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8F25_RS14920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H8F25_RS14925	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8F25_RS14935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8F25_RS14940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8F25_RS14945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H8F25_RS14950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8F25_RS14955	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8F25_RS14960	COG0089	rRNA binding
H8F25_RS14965	COG0088	Forms part of the polypeptide exit tunnel
H8F25_RS14970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8F25_RS14980	COG3263	regulation of cellular component size
H8F25_RS14990	COG3854	ATPases associated with a variety of cellular activities
H8F25_RS15005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8F25_RS15030	COG1233	COG1233 Phytoene dehydrogenase and related
H8F25_RS15040	COG3001	Fructosamine kinase
H8F25_RS15070	COG2197	response regulator
H8F25_RS15080	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H8F25_RS15085	COG1606	tRNA processing
H8F25_RS15090	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8F25_RS15095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8F25_RS15105	COG0454	-acetyltransferase
H8F25_RS15110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8F25_RS15115	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H8F25_RS15120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8F25_RS15135	COG0772	Belongs to the SEDS family
H8F25_RS15140	COG0489	protein tyrosine kinase activity
H8F25_RS15145	COG0408	coproporphyrinogen oxidase activity
H8F25_RS15240	COG0667	Aldo Keto reductase
H8F25_RS15250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8F25_RS15255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8F25_RS15260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8F25_RS15260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8F25_RS15265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8F25_RS15325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8F25_RS15340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F25_RS15370	COG1215	transferase activity, transferring glycosyl groups
H8F25_RS15400	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8F25_RS15420	COG0314	molybdopterin synthase activity
H8F25_RS15425	COG0303	'Molybdopterin
H8F25_RS15430	COG0315	cyclic pyranopterin monophosphate synthase activity
H8F25_RS15450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F25_RS15455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F25_RS15460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F25_RS15510	COG3639	organic phosphonate transmembrane transporter activity
H8F25_RS15515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8F25_RS15515	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H8F25_RS15520	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H8F25_RS15530	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H8F25_RS15550	COG0745	RESPONSE REGULATOR receiver
H8F25_RS15560	COG1253	flavin adenine dinucleotide binding
H8F25_RS15565	COG3039	Transposase
H8F25_RS15570	COG1253	flavin adenine dinucleotide binding
H8F25_RS15585	COG0009	L-threonylcarbamoyladenylate synthase
H8F25_RS15595	COG0758	DNA mediated transformation
H8F25_RS15605	COG0589	response to stress
H8F25_RS15630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8F25_RS15635	COG0539	negative regulation of cytoplasmic translation
H8F25_RS15640	COG0546	phosphoglycolate phosphatase activity
H8F25_RS15645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8F25_RS15650	COG1070	Carbohydrate kinase
H8F25_RS15660	COG1040	competence protein
H8F25_RS15690	COG0730	response to heat
H8F25_RS15700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8F25_RS15740	COG2223	nitrite transmembrane transporter activity
H8F25_RS15745	COG0243	molybdopterin cofactor binding
H8F25_RS15755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8F25_RS15760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F25_RS15790	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8F25_RS15795	COG2894	cell division
H8F25_RS15815	COG0850	regulation of cytokinetic process
H8F25_RS15820	COG1078	dGTPase activity
H8F25_RS15825	COG0793	Belongs to the peptidase S41A family
H8F25_RS15830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8F25_RS15835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8F25_RS15885	COG1722	exodeoxyribonuclease VII activity
H8F25_RS15890	COG1570	exodeoxyribonuclease VII activity
H8F25_RS15905	COG1643	Atp-dependent helicase
H8F25_RS15920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F25_RS15940	COG0488	(ABC) transporter
H8F25_RS15960	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H8F25_RS15965	COG0569	domain protein
H8F25_RS15970	COG0450	alkyl hydroperoxide reductase
H8F25_RS15975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8F25_RS15985	COG1252	NADH dehydrogenase
H8F25_RS15990	COG0175	sulfate reduction
H8F25_RS15995	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8F25_RS16000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F25_RS16035	COG2066	Belongs to the glutaminase family
H8F25_RS16040	COG0786	glutamate:sodium symporter activity
H8F25_RS16045	COG3039	Transposase
H8F25_RS16055	COG0786	glutamate:sodium symporter activity
H8F25_RS16065	COG0033	Phosphoglucomutase
H8F25_RS16105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F25_RS16125	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
H8F25_RS16130	COG0719	Fe-S assembly protein
H8F25_RS16135	COG0396	ATPase activity
H8F25_RS16140	COG0719	Fe-S assembly protein
H8F25_RS16145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8F25_RS16165	COG0717	Belongs to the dCTP deaminase family
H8F25_RS16185	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8F25_RS16190	COG2226	methyltransferase
H8F25_RS16195	COG0604	alcohol dehydrogenase
H8F25_RS16205	COG0501	Belongs to the peptidase M48B family
H8F25_RS16210	COG1028	Short-chain dehydrogenase reductase Sdr
H8F25_RS16210	COG3347	Dehydrogenase
H8F25_RS16215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8F25_RS16220	COG0268	Binds directly to 16S ribosomal RNA
H8F25_RS16225	COG0084	hydrolase, TatD family'
H8F25_RS16235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8F25_RS16240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8F25_RS16245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F25_RS16290	COG0357	Ribosomal RNA small subunit methyltransferase G
H8F25_RS16295	COG0484	heat shock protein binding
H8F25_RS16305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8F25_RS16320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8F25_RS16325	COG2226	methyltransferase
H8F25_RS16335	COG0156	8-amino-7-oxononanoate synthase activity
H8F25_RS16350	COG4581	dead DEAH box helicase
H8F25_RS16355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8F25_RS16370	COG0457	Tetratricopeptide repeat
H8F25_RS16370	COG0515	serine threonine protein kinase
H8F25_RS16385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8F25_RS16400	COG0006	proline dipeptidase activity
H8F25_RS16405	COG1253	flavin adenine dinucleotide binding
H8F25_RS16410	COG1160	GTP binding
H8F25_RS16415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8F25_RS16420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F25_RS16420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8F25_RS16475	COG0686	Belongs to the AlaDH PNT family
H8F25_RS16480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F25_RS16490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F25_RS16520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8F25_RS16530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8F25_RS16535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8F25_RS16555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F25_RS16560	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F25_RS16580	COG0772	Belongs to the SEDS family
H8F25_RS16590	COG1333	cytochrome c biogenesis protein
H8F25_RS16595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8F25_RS16600	COG0347	Belongs to the P(II) protein family
H8F25_RS16615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H8F25_RS16620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8F25_RS16640	COG1429	ligase activity, forming nitrogen-metal bonds
H8F25_RS16645	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H8F25_RS16650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8F25_RS16660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F25_RS16665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8F25_RS16675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8F25_RS16705	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H8F25_RS16755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F25_RS16770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8F25_RS16780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8F25_RS16785	COG0142	geranyltranstransferase activity
H8F25_RS16790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H8F25_RS16805	COG2045	Belongs to the ComB family
H8F25_RS16810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H8F25_RS16820	COG0644	oxidoreductase
H8F25_RS16830	COG0668	transmembrane transport
H8F25_RS16835	COG1177	transmembrane transport
H8F25_RS16840	COG1176	ABC-type spermidine putrescine transport system, permease component I
H8F25_RS16855	COG0708	Exodeoxyribonuclease III
H8F25_RS16875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F25_RS16880	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H8F25_RS16890	COG0735	belongs to the Fur family
H8F25_RS16905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F25_RS16910	COG0745	RESPONSE REGULATOR receiver
H8F25_RS16915	COG5002	protein histidine kinase activity
H8F25_RS16925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8F25_RS16930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F25_RS16935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F25_RS16940	COG0259	pyridoxamine-phosphate oxidase activity
H8F25_RS16945	COG0500	methyltransferase
H8F25_RS16970	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H8F25_RS16975	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H8F25_RS16995	COG0598	Magnesium transport protein CorA
H8F25_RS17000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8F25_RS17030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8F25_RS17045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F25_RS17055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8F25_RS17065	COG0297	glycogen (starch) synthase activity
H8F25_RS17075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H8F25_RS17080	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H8F25_RS17090	COG0681	Belongs to the peptidase S26 family
H8F25_RS17105	COG0428	transporter
H8F25_RS17125	COG0180	Tryptophanyl-tRNA synthetase
H8F25_RS17140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8F25_RS17145	COG0837	glucose binding
H8F25_RS17150	COG0083	homoserine kinase activity
H8F25_RS17155	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F25_RS17160	COG0339	signal peptide processing
H8F25_RS17185	COG3012	SEC-C Motif Domain Protein
H8F25_RS17215	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8F25_RS17220	COG1940	carbohydrate kinase activity
H8F25_RS17255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8F25_RS17265	COG0004	ammonium transporteR
H8F25_RS17290	COG1196	nuclear chromosome segregation
H8F25_RS17290	COG3264	Mechanosensitive ion channel
H8F25_RS17300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8F25_RS17310	COG2010	Cytochrome c
H8F25_RS17350	COG0542	response to heat
H8F25_RS17360	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8F25_RS17370	COG0432	Pfam Uncharacterised protein family UPF0047
H8F25_RS17405	COG1799	cell septum assembly
H8F25_RS17410	COG0251	oxidation-reduction process
H8F25_RS17420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8F25_RS17425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8F25_RS17430	COG1132	(ABC) transporter
H8F25_RS17435	COG0596	Alpha beta hydrolase
H8F25_RS17440	COG0456	acetyltransferase
H8F25_RS17445	COG0463	Glycosyl transferase, family 2
H8F25_RS17455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain