locus-tag	class	description
H8F26_RS00025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F26_RS00030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F26_RS00040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F26_RS00045	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
H8F26_RS00065	COG4451	ribulose bisphosphate carboxylase, small
H8F26_RS00070	COG1850	ribulose-bisphosphate carboxylase activity
H8F26_RS00075	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F26_RS00090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8F26_RS00095	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F26_RS00100	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F26_RS00105	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F26_RS00110	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H8F26_RS00135	COG0730	response to heat
H8F26_RS00140	COG0095	Lipoate-protein ligase
H8F26_RS00145	COG0517	IMP dehydrogenase activity
H8F26_RS00145	COG1994	Peptidase M50
H8F26_RS00150	COG0135	phosphoribosylanthranilate isomerase activity
H8F26_RS00160	COG0302	gtp cyclohydrolase
H8F26_RS00170	COG0825	malonyl-CoA metabolic process
H8F26_RS00175	COG5322	oxidoreductase activity
H8F26_RS00180	COG3396	Phenylacetate-CoA oxygenase
H8F26_RS00190	COG0539	negative regulation of cytoplasmic translation
H8F26_RS00205	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H8F26_RS00220	COG0737	Belongs to the 5'-nucleotidase family
H8F26_RS00225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8F26_RS00225	COG0574	Belongs to the PEP-utilizing enzyme family
H8F26_RS00245	COG0028	Belongs to the TPP enzyme family
H8F26_RS00255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F26_RS00275	COG0528	UMP kinase activity
H8F26_RS00280	COG0233	cytoplasmic translational termination
H8F26_RS00285	COG0644	oxidoreductase
H8F26_RS00295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8F26_RS00315	COG0588	phosphoglycerate mutase activity
H8F26_RS00325	COG0681	Belongs to the peptidase S26 family
H8F26_RS00345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F26_RS00350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8F26_RS00360	COG0442	prolyl-tRNA aminoacylation
H8F26_RS00370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8F26_RS00375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F26_RS00405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8F26_RS00415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8F26_RS00420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F26_RS00425	COG1215	transferase activity, transferring glycosyl groups
H8F26_RS00445	COG0181	hydroxymethylbilane synthase activity
H8F26_RS00465	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H8F26_RS00470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F26_RS00505	COG3706	GGDEF domain
H8F26_RS00510	COG0426	domain, Protein
H8F26_RS00510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F26_RS00515	COG0284	orotidine-5'-phosphate decarboxylase activity
H8F26_RS00520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8F26_RS00530	COG2197	response regulator
H8F26_RS00545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8F26_RS00560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F26_RS00570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F26_RS00575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8F26_RS00580	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8F26_RS00590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8F26_RS00600	COG0151	Belongs to the GarS family
H8F26_RS00605	COG5002	protein histidine kinase activity
H8F26_RS00610	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8F26_RS00625	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8F26_RS00630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8F26_RS00635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F26_RS00640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8F26_RS00645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8F26_RS00650	COG0217	transcriptional regulatory protein
H8F26_RS00655	COG0363	glucosamine-6-phosphate deaminase activity
H8F26_RS00660	COG2385	sporulation resulting in formation of a cellular spore
H8F26_RS00665	COG1234	tRNA 3'-trailer cleavage
H8F26_RS00670	COG2010	Cytochrome c
H8F26_RS00685	COG2264	protein methyltransferase activity
H8F26_RS00690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8F26_RS00710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8F26_RS00735	COG0443	Heat shock 70 kDa protein
H8F26_RS00750	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H8F26_RS00775	COG0459	protein refolding
H8F26_RS00780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H8F26_RS00785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8F26_RS00790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8F26_RS00800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8F26_RS00850	COG0006	proline dipeptidase activity
H8F26_RS00855	COG1253	flavin adenine dinucleotide binding
H8F26_RS00860	COG1160	GTP binding
H8F26_RS00865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8F26_RS00870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8F26_RS00870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F26_RS00875	COG0686	Belongs to the AlaDH PNT family
H8F26_RS00880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F26_RS00890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F26_RS00900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8F26_RS00905	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8F26_RS00915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8F26_RS00920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8F26_RS00940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F26_RS00945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F26_RS00965	COG0772	Belongs to the SEDS family
H8F26_RS00980	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8F26_RS00985	COG0347	Belongs to the P(II) protein family
H8F26_RS01005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H8F26_RS01015	COG1088	dTDP-glucose 4,6-dehydratase activity
H8F26_RS01025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H8F26_RS01030	COG4581	dead DEAH box helicase
H8F26_RS01035	COG0385	Bile acid
H8F26_RS01040	COG0156	8-amino-7-oxononanoate synthase activity
H8F26_RS01055	COG4106	trans-aconitate 2-methyltransferase activity
H8F26_RS01055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8F26_RS01060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8F26_RS01075	COG0357	Ribosomal RNA small subunit methyltransferase G
H8F26_RS01115	COG2223	nitrite transmembrane transporter activity
H8F26_RS01120	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8F26_RS01130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8F26_RS01135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8F26_RS01140	COG0085	RNA polymerase activity
H8F26_RS01145	COG0084	hydrolase, TatD family'
H8F26_RS01150	COG0268	Binds directly to 16S ribosomal RNA
H8F26_RS01155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8F26_RS01160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8F26_RS01165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F26_RS01170	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H8F26_RS01180	COG0779	Required for maturation of 30S ribosomal subunits
H8F26_RS01185	COG0195	Participates in both transcription termination and antitermination
H8F26_RS01195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8F26_RS01225	COG0484	heat shock protein binding
H8F26_RS01240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8F26_RS01250	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS01290	COG2274	protein secretion by the type I secretion system
H8F26_RS01305	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS01305	COG1216	Glycosyl transferase, family 2
H8F26_RS01335	COG2988	succinylglutamate desuccinylase activity
H8F26_RS01340	COG0435	Glutathione S-transferase
H8F26_RS01350	COG0488	(ABC) transporter
H8F26_RS01365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8F26_RS01370	COG3842	ATPase activity
H8F26_RS01375	COG1193	negative regulation of DNA recombination
H8F26_RS01385	COG0113	porphobilinogen synthase activity
H8F26_RS01390	COG0484	heat shock protein binding
H8F26_RS01450	COG1484	DNA-dependent DNA replication
H8F26_RS01480	COG2755	lipolytic protein G-D-S-L family
H8F26_RS01480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8F26_RS01515	COG0408	coproporphyrinogen oxidase activity
H8F26_RS01520	COG0489	protein tyrosine kinase activity
H8F26_RS01525	COG0772	Belongs to the SEDS family
H8F26_RS01540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8F26_RS01545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H8F26_RS01550	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8F26_RS01565	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8F26_RS01570	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8F26_RS01575	COG1606	tRNA processing
H8F26_RS01580	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H8F26_RS01605	COG3001	Fructosamine kinase
H8F26_RS01650	COG3854	ATPases associated with a variety of cellular activities
H8F26_RS01665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8F26_RS01670	COG0088	Forms part of the polypeptide exit tunnel
H8F26_RS01675	COG0089	rRNA binding
H8F26_RS01685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8F26_RS01690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H8F26_RS01695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8F26_RS01705	COG0255	Belongs to the universal ribosomal protein uL29 family
H8F26_RS01710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8F26_RS01715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H8F26_RS01720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8F26_RS01725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8F26_RS01730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8F26_RS01735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8F26_RS01740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8F26_RS01745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H8F26_RS01750	COG0200	Binds to the 23S rRNA
H8F26_RS01755	COG0201	protein transport
H8F26_RS01760	COG0563	adenylate kinase activity
H8F26_RS01765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H8F26_RS01770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H8F26_RS01775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H8F26_RS01780	COG0202	RNA polymerase activity
H8F26_RS01790	COG0101	tRNA pseudouridine synthase activity
H8F26_RS01795	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H8F26_RS01800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8F26_RS01810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8F26_RS01820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8F26_RS01840	COG0463	Glycosyl transferase, family 2
H8F26_RS01855	COG2885	chlorophyll binding
H8F26_RS01860	COG2885	chlorophyll binding
H8F26_RS01880	COG5001	Diguanylate cyclase
H8F26_RS01880	COG3447	MASE1 domain protein
H8F26_RS01880	COG5002	protein histidine kinase activity
H8F26_RS01890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8F26_RS01895	COG0070	glutamate synthase
H8F26_RS01895	COG0069	glutamate synthase activity
H8F26_RS01895	COG0067	glutamate synthase
H8F26_RS01910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8F26_RS01915	COG0049	tRNA binding
H8F26_RS01920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8F26_RS01925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8F26_RS01930	COG0051	transcription antitermination factor activity, RNA binding
H8F26_RS01940	COG2226	methyltransferase
H8F26_RS01945	COG0077	Prephenate dehydratase
H8F26_RS01945	COG1605	Chorismate mutase
H8F26_RS01955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8F26_RS01960	COG1530	ribonuclease E activity
H8F26_RS01970	COG0436	Aminotransferase
H8F26_RS01975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8F26_RS01985	COG5002	protein histidine kinase activity
H8F26_RS02040	COG3328	transposase activity
H8F26_RS02060	COG3328	transposase activity
H8F26_RS02100	COG3386	PFAM SMP-30 Gluconolaconase
H8F26_RS02130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F26_RS02170	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8F26_RS02175	COG0800	Aldolase
H8F26_RS02180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F26_RS02185	COG2046	Belongs to the sulfate adenylyltransferase family
H8F26_RS02185	COG0529	Catalyzes the synthesis of activated sulfate
H8F26_RS02200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8F26_RS02205	COG3536	Protein conserved in bacteria
H8F26_RS02230	COG1484	DNA-dependent DNA replication
H8F26_RS02265	COG3551	Protein conserved in bacteria
H8F26_RS02325	COG3321	synthase
H8F26_RS02325	COG0604	alcohol dehydrogenase
H8F26_RS02380	COG2801	Transposase and inactivated derivatives
H8F26_RS02435	COG1484	DNA-dependent DNA replication
H8F26_RS02455	COG3328	transposase activity
H8F26_RS02550	COG3321	synthase
H8F26_RS02550	COG0604	alcohol dehydrogenase
H8F26_RS02615	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F26_RS02630	COG0540	Belongs to the ATCase OTCase family
H8F26_RS02635	COG2094	Belongs to the DNA glycosylase MPG family
H8F26_RS02670	COG3328	transposase activity
H8F26_RS02680	COG2094	Belongs to the DNA glycosylase MPG family
H8F26_RS02700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8F26_RS02720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8F26_RS02740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8F26_RS02755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8F26_RS02765	COG0741	lytic transglycosylase activity
H8F26_RS02780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8F26_RS02790	COG0717	Belongs to the dCTP deaminase family
H8F26_RS02800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F26_RS02810	COG4372	Transposase
H8F26_RS02825	COG0193	aminoacyl-tRNA hydrolase activity
H8F26_RS02830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8F26_RS02865	COG0066	3-isopropylmalate dehydratase activity
H8F26_RS02870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8F26_RS02875	COG2860	membrane
H8F26_RS02880	COG3224	Antibiotic biosynthesis monooxygenase
H8F26_RS02885	COG1546	Belongs to the CinA family
H8F26_RS02885	COG1058	Belongs to the CinA family
H8F26_RS02890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F26_RS02895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8F26_RS02945	COG0728	peptidoglycan biosynthetic process
H8F26_RS02950	COG1489	DNA binding
H8F26_RS02955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8F26_RS02970	COG0138	bifunctional purine biosynthesis protein purh
H8F26_RS02990	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H8F26_RS02995	COG0343	queuine tRNA-ribosyltransferase activity
H8F26_RS03015	COG0673	inositol 2-dehydrogenase activity
H8F26_RS03020	COG1253	flavin adenine dinucleotide binding
H8F26_RS03025	COG0318	PFAM AMP-dependent synthetase and ligase
H8F26_RS03095	COG3300	MHYT domain
H8F26_RS03095	COG5001	Diguanylate cyclase
H8F26_RS03110	COG1216	Glycosyl transferase, family 2
H8F26_RS03245	COG2026	Addiction module toxin, RelE StbE family
H8F26_RS03305	COG0402	S-adenosylhomocysteine deaminase activity
H8F26_RS03310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H8F26_RS03310	COG0784	Response regulator, receiver
H8F26_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
H8F26_RS03365	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H8F26_RS03385	COG0673	inositol 2-dehydrogenase activity
H8F26_RS03395	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8F26_RS03405	COG2267	carboxylic ester hydrolase activity
H8F26_RS03435	COG0519	Catalyzes the synthesis of GMP from XMP
H8F26_RS03435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8F26_RS03450	COG0768	penicillin binding
H8F26_RS03470	COG2022	thiamine diphosphate biosynthetic process
H8F26_RS03485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H8F26_RS03490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H8F26_RS03500	COG1215	transferase activity, transferring glycosyl groups
H8F26_RS03505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H8F26_RS03515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8F26_RS03520	COG0740	serine-type endopeptidase activity
H8F26_RS03525	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8F26_RS03530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8F26_RS03535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8F26_RS03540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H8F26_RS03550	COG0037	tRNA processing
H8F26_RS03565	COG0556	nucleotide-excision repair
H8F26_RS03575	COG0527	aspartate kinase activity
H8F26_RS03585	COG2082	Precorrin-8x methylmutase
H8F26_RS03590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8F26_RS03600	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8F26_RS03605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F26_RS03610	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H8F26_RS03615	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS03630	COG1215	transferase activity, transferring glycosyl groups
H8F26_RS03705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F26_RS03725	COG0454	-acetyltransferase
H8F26_RS03730	COG0297	glycogen (starch) synthase activity
H8F26_RS03735	COG0653	protein targeting
H8F26_RS03750	COG1045	serine acetyltransferase
H8F26_RS03755	COG1725	Transcriptional regulator
H8F26_RS03770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8F26_RS03775	COG0187	DNA topoisomerase II activity
H8F26_RS03775	COG1372	Participates in initiation and elongation during chromosome replication
H8F26_RS03785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8F26_RS03790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8F26_RS03795	COG0386	Belongs to the glutathione peroxidase family
H8F26_RS03810	COG2239	Acts as a magnesium transporter
H8F26_RS03815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F26_RS03820	COG0174	glutamine synthetase
H8F26_RS03850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F26_RS03855	COG0802	atpase or kinase
H8F26_RS03860	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8F26_RS03865	COG0629	single-stranded DNA binding
H8F26_RS03890	COG0745	RESPONSE REGULATOR receiver
H8F26_RS03895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8F26_RS03920	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H8F26_RS03925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F26_RS03935	COG0515	serine threonine protein kinase
H8F26_RS03955	COG1473	amidohydrolase
H8F26_RS03970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8F26_RS03990	COG1372	Participates in initiation and elongation during chromosome replication
H8F26_RS03990	COG0305	Participates in initiation and elongation during chromosome replication
H8F26_RS03990	COG0305	Participates in initiation and elongation during chromosome replication
H8F26_RS03990	COG1372	Participates in initiation and elongation during chromosome replication
H8F26_RS03995	COG0359	binds to the 23S rRNA
H8F26_RS04015	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H8F26_RS04020	COG0509	glycine decarboxylation via glycine cleavage system
H8F26_RS04045	COG3328	transposase activity
H8F26_RS04055	COG1773	rubredoxin
H8F26_RS04055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F26_RS04060	COG0426	domain, Protein
H8F26_RS04060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F26_RS04070	COG0426	domain, Protein
H8F26_RS04070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F26_RS04090	COG1648	precorrin-2 dehydrogenase activity
H8F26_RS04090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8F26_RS04105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F26_RS04115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8F26_RS04125	COG0243	molybdopterin cofactor binding
H8F26_RS04130	COG2223	nitrite transmembrane transporter activity
H8F26_RS04145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8F26_RS04180	COG3657	addiction module killer protein
H8F26_RS04185	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F26_RS04240	COG3328	transposase activity
H8F26_RS04260	COG1597	lipid kinase activity
H8F26_RS04260	COG1803	Methylglyoxal synthase
H8F26_RS04265	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8F26_RS04280	COG0590	tRNA wobble adenosine to inosine editing
H8F26_RS04290	COG0314	molybdopterin synthase activity
H8F26_RS04295	COG0730	response to heat
H8F26_RS04320	COG0561	phosphatase activity
H8F26_RS04320	COG3100	YcgL domain-containing protein
H8F26_RS04325	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS04330	COG0303	'Molybdopterin
H8F26_RS04335	COG0393	Putative heavy-metal-binding
H8F26_RS04340	COG0315	cyclic pyranopterin monophosphate synthase activity
H8F26_RS04350	COG1053	succinate dehydrogenase
H8F26_RS04365	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8F26_RS04370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F26_RS04375	COG0170	dolichyl monophosphate biosynthetic process
H8F26_RS04385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8F26_RS04390	COG1049	propionate catabolic process, 2-methylcitrate cycle
H8F26_RS04450	COG0788	formyltetrahydrofolate deformylase activity
H8F26_RS04460	COG2022	thiamine diphosphate biosynthetic process
H8F26_RS04460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F26_RS04465	COG0443	Heat shock 70 kDa protein
H8F26_RS04470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F26_RS04500	COG2124	cytochrome p450
H8F26_RS04515	COG0457	Tetratricopeptide repeat
H8F26_RS04515	COG0463	Glycosyl transferase, family 2
H8F26_RS04535	COG0137	argininosuccinate synthase activity
H8F26_RS04550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F26_RS04565	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8F26_RS04570	COG1316	TRANSCRIPTIONal
H8F26_RS04580	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS04630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8F26_RS04650	COG0497	DNA recombination
H8F26_RS04655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F26_RS04665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8F26_RS04670	COG0592	DNA-directed DNA polymerase activity
H8F26_RS04685	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H8F26_RS04690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8F26_RS04700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8F26_RS04715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F26_RS04720	COG0552	protein localization to endoplasmic reticulum
H8F26_RS04725	COG2208	phosphoserine phosphatase activity
H8F26_RS04730	COG0165	Argininosuccinate lyase
H8F26_RS04735	COG0724	RNA recognition motif
H8F26_RS04740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F26_RS04745	COG2081	HI0933 family
H8F26_RS04750	COG1459	type II secretion system
H8F26_RS04760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8F26_RS04765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8F26_RS04770	COG0484	heat shock protein binding
H8F26_RS04780	COG1162	GTPase activity
H8F26_RS04785	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8F26_RS04790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8F26_RS04795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8F26_RS04800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F26_RS04805	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8F26_RS04810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F26_RS04815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8F26_RS04820	COG0511	ligase activity, forming carbon-carbon bonds
H8F26_RS04825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8F26_RS04850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F26_RS04885	COG0071	Belongs to the small heat shock protein (HSP20) family
H8F26_RS04895	COG3328	transposase activity
H8F26_RS04930	COG3328	transposase activity
H8F26_RS05000	COG2217	Heavy metal translocating P-type atpase
H8F26_RS05010	COG2132	Multicopper oxidase
H8F26_RS05030	COG2226	methyltransferase
H8F26_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
H8F26_RS05065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8F26_RS05070	COG0354	folic acid binding
H8F26_RS05080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8F26_RS05085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8F26_RS05095	COG1595	DNA-templated transcription, initiation
H8F26_RS05130	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H8F26_RS05140	COG0131	Imidazoleglycerol-phosphate dehydratase
H8F26_RS05150	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8F26_RS05175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8F26_RS05175	COG0189	ligase activity
H8F26_RS05185	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8F26_RS05185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8F26_RS05200	COG0415	Belongs to the DNA photolyase family
H8F26_RS05210	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F26_RS05210	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F26_RS05220	COG3842	ATPase activity
H8F26_RS05225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H8F26_RS05230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F26_RS05235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F26_RS05240	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F26_RS05245	COG1773	rubredoxin
H8F26_RS05250	COG4447	cellulose binding
H8F26_RS05280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F26_RS05285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8F26_RS05290	COG0124	histidyl-tRNA synthetase
H8F26_RS05295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8F26_RS05300	COG0709	Synthesizes selenophosphate from selenide and ATP
H8F26_RS05305	COG0617	tRNA 3'-terminal CCA addition
H8F26_RS05315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8F26_RS05330	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8F26_RS05350	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS05355	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS05375	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS05390	COG5398	heme oxygenase
H8F26_RS05400	COG0538	isocitrate dehydrogenase activity
H8F26_RS05405	COG0247	lactate metabolic process
H8F26_RS05410	COG0435	Glutathione S-transferase
H8F26_RS05420	COG0277	FAD linked oxidase domain protein
H8F26_RS05445	COG0475	glutathione-regulated potassium exporter activity
H8F26_RS05450	COG0058	SHG alpha-glucan phosphorylase activity
H8F26_RS05470	COG0390	transport system, permease component
H8F26_RS05475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8F26_RS05510	COG0571	ribonuclease III activity
H8F26_RS05520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8F26_RS05535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8F26_RS05540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F26_RS05545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8F26_RS05550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8F26_RS05555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8F26_RS05570	COG2124	cytochrome p450
H8F26_RS05580	COG2133	pyrroloquinoline quinone binding
H8F26_RS05600	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H8F26_RS05605	COG0445	tRNA wobble uridine modification
H8F26_RS05645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F26_RS05660	COG0398	Pfam SNARE associated Golgi protein
H8F26_RS05665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8F26_RS05675	COG1970	mechanosensitive ion channel activity
H8F26_RS05750	COG1970	mechanosensitive ion channel activity
H8F26_RS05795	COG0525	valine-tRNA ligase activity
H8F26_RS05815	COG2226	methyltransferase
H8F26_RS05825	COG3264	Mechanosensitive ion channel
H8F26_RS05825	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H8F26_RS05830	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F26_RS05850	COG5001	Diguanylate cyclase
H8F26_RS05855	COG3300	MHYT domain
H8F26_RS05855	COG5001	Diguanylate cyclase
H8F26_RS05875	COG0058	SHG alpha-glucan phosphorylase activity
H8F26_RS05890	COG2308	Evidence 4 Homologs of previously reported genes of
H8F26_RS05900	COG0804	urea catabolic process
H8F26_RS05905	COG0832	Belongs to the urease beta subunit family
H8F26_RS05910	COG0831	urea catabolic process
H8F26_RS05920	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H8F26_RS05925	COG0830	nickel cation binding
H8F26_RS05930	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H8F26_RS05950	COG0411	ABC transporter
H8F26_RS05965	COG0823	Involved in the tonB-independent uptake of proteins
H8F26_RS05965	COG1506	peptidase
H8F26_RS05975	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8F26_RS05980	COG4574	serine-type endopeptidase inhibitor activity
H8F26_RS05985	COG0602	queuosine metabolic process
H8F26_RS05995	COG0783	Belongs to the Dps family
H8F26_RS06005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8F26_RS06015	COG1051	belongs to the nudix hydrolase family
H8F26_RS06020	COG1028	Short-chain dehydrogenase reductase Sdr
H8F26_RS06025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8F26_RS06025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8F26_RS06030	COG1215	transferase activity, transferring glycosyl groups
H8F26_RS06035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8F26_RS06040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8F26_RS06055	COG0010	Belongs to the arginase family
H8F26_RS06060	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8F26_RS06070	COG3956	TIGRFAM MazG family protein
H8F26_RS06130	COG3300	MHYT domain
H8F26_RS06130	COG5001	Diguanylate cyclase
H8F26_RS06245	COG2205	protein histidine kinase activity
H8F26_RS06245	COG0784	Response regulator, receiver
H8F26_RS06245	COG5002	protein histidine kinase activity
H8F26_RS06250	COG3437	response regulator, receiver
H8F26_RS06295	COG3706	GGDEF domain
H8F26_RS06295	COG4251	negative regulation of phosphorylation
H8F26_RS06295	COG5001	Diguanylate cyclase
H8F26_RS06295	COG2203	Gaf domain
H8F26_RS06300	COG5002	protein histidine kinase activity
H8F26_RS06300	COG2205	protein histidine kinase activity
H8F26_RS06300	COG0784	Response regulator, receiver
H8F26_RS06370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F26_RS06380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8F26_RS06405	COG0415	Belongs to the DNA photolyase family
H8F26_RS06415	COG0628	permease
H8F26_RS06435	COG0475	glutathione-regulated potassium exporter activity
H8F26_RS06445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F26_RS06455	COG1231	oxidoreductase activity
H8F26_RS06470	COG0641	radical SAM
H8F26_RS06485	COG0157	Belongs to the NadC ModD family
H8F26_RS06490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8F26_RS06510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8F26_RS06515	COG4172	Belongs to the ABC transporter superfamily
H8F26_RS06530	COG0564	pseudouridine synthase activity
H8F26_RS06540	COG0589	response to stress
H8F26_RS06545	COG0126	phosphoglycerate kinase activity
H8F26_RS06590	COG2084	Dehydrogenase
H8F26_RS06595	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H8F26_RS06605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8F26_RS06610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F26_RS06615	COG0714	Associated with various cellular activities
H8F26_RS06665	COG0167	dihydroorotate dehydrogenase activity
H8F26_RS06670	COG0328	RNA-DNA hybrid ribonuclease activity
H8F26_RS06680	COG0222	ribosome binding
H8F26_RS06685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8F26_RS06695	COG0765	amino acid transport
H8F26_RS06700	COG0081	regulation of translation
H8F26_RS06705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8F26_RS06710	COG0250	Participates in transcription elongation, termination and antitermination
H8F26_RS06715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8F26_RS06720	COG0542	response to heat
H8F26_RS06725	COG0346	lactoylglutathione lyase activity
H8F26_RS06730	COG0148	phosphopyruvate hydratase activity
H8F26_RS06735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F26_RS06755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8F26_RS06755	COG2755	lipolytic protein G-D-S-L family
H8F26_RS06765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H8F26_RS06770	COG4260	virion core protein, lumpy skin disease virus
H8F26_RS06780	COG0237	dephospho-CoA kinase activity
H8F26_RS06795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8F26_RS06800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F26_RS06800	COG2022	thiamine diphosphate biosynthetic process
H8F26_RS06805	COG0105	UTP biosynthetic process
H8F26_RS06810	COG1166	arginine decarboxylase activity
H8F26_RS06830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F26_RS06875	COG2226	methyltransferase
H8F26_RS06895	COG2144	transferase activity, transferring acyl groups
H8F26_RS06955	COG1028	Short-chain dehydrogenase reductase Sdr
H8F26_RS06995	COG1119	ATPase activity
H8F26_RS07010	COG1799	cell septum assembly
H8F26_RS07020	COG0529	Catalyzes the synthesis of activated sulfate
H8F26_RS07025	COG0628	permease
H8F26_RS07030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H8F26_RS07040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F26_RS07055	COG0564	pseudouridine synthase activity
H8F26_RS07070	COG1104	cysteine desulfurase activity
H8F26_RS07080	COG0275	rRNA processing
H8F26_RS07085	COG0649	NAD binding
H8F26_RS07100	COG0824	Thioesterase
H8F26_RS07115	COG0318	PFAM AMP-dependent synthetase and ligase
H8F26_RS07125	COG1575	Belongs to the MenA family. Type 1 subfamily
H8F26_RS07135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F26_RS07140	COG0189	ligase activity
H8F26_RS07145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8F26_RS07165	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8F26_RS07170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8F26_RS07185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F26_RS07255	COG1484	DNA-dependent DNA replication
H8F26_RS07260	COG3328	transposase activity
H8F26_RS07265	COG0018	arginyl-trna synthetase
H8F26_RS07270	COG2116	formate transmembrane transporter activity
H8F26_RS07275	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H8F26_RS07285	COG2376	Dihydroxyacetone kinase
H8F26_RS07295	COG0023	Translation Initiation Factor
H8F26_RS07305	COG0133	tryptophan synthase activity
H8F26_RS07315	COG1420	regulation of RNA biosynthetic process
H8F26_RS07320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8F26_RS07330	COG2062	phosphohistidine phosphatase, SixA
H8F26_RS07335	COG0372	Belongs to the citrate synthase family
H8F26_RS07340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8F26_RS07350	COG0839	Belongs to the complex I subunit 6 family
H8F26_RS07355	COG0713	ATP synthesis coupled electron transport
H8F26_RS07360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8F26_RS07370	COG2197	response regulator
H8F26_RS07380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8F26_RS07395	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F26_RS07400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F26_RS07410	COG0583	DNA-binding transcription factor activity
H8F26_RS07425	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H8F26_RS07425	COG0493	'glutamate synthase
H8F26_RS07430	COG1562	ergosterol biosynthetic process
H8F26_RS07445	COG0617	tRNA 3'-terminal CCA addition
H8F26_RS07455	COG1214	PFAM Peptidase M22, glycoprotease
H8F26_RS07470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8F26_RS07475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8F26_RS07480	COG0416	fatty acid biosynthetic process
H8F26_RS07485	COG0745	RESPONSE REGULATOR receiver
H8F26_RS07490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H8F26_RS07495	COG3063	Type IV pilus biogenesis stability protein PilW
H8F26_RS07500	COG2217	Heavy metal translocating P-type atpase
H8F26_RS07505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8F26_RS07515	COG0745	RESPONSE REGULATOR receiver
H8F26_RS07525	COG1122	ATPase activity
H8F26_RS07570	COG3659	wide pore channel activity
H8F26_RS07575	COG3659	wide pore channel activity
H8F26_RS07580	COG0484	heat shock protein binding
H8F26_RS07595	COG1090	epimerase
H8F26_RS07615	COG0316	Belongs to the HesB IscA family
H8F26_RS07620	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H8F26_RS07635	COG1587	Uroporphyrinogen-III synthase
H8F26_RS07640	COG1472	Belongs to the glycosyl hydrolase 3 family
H8F26_RS07645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8F26_RS07670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8F26_RS07700	COG1032	radical SAM domain protein
H8F26_RS07715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F26_RS07720	COG4243	Vitamin k epoxide reductase
H8F26_RS07725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H8F26_RS07730	COG1555	photosystem II stabilization
H8F26_RS07740	COG1968	undecaprenyl-diphosphatase activity
H8F26_RS07810	COG1570	exodeoxyribonuclease VII activity
H8F26_RS07820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F26_RS07835	COG1643	Atp-dependent helicase
H8F26_RS07850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F26_RS07865	COG0488	(ABC) transporter
H8F26_RS07895	COG0569	domain protein
H8F26_RS07900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8F26_RS07905	COG0450	alkyl hydroperoxide reductase
H8F26_RS07910	COG0471	metal ion transport
H8F26_RS07910	COG3273	potassium ion transport
H8F26_RS07915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8F26_RS07925	COG1252	NADH dehydrogenase
H8F26_RS07930	COG0175	sulfate reduction
H8F26_RS07935	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8F26_RS07940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F26_RS07960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F26_RS07965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8F26_RS08000	COG0033	Phosphoglucomutase
H8F26_RS08025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8F26_RS08040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F26_RS08060	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
H8F26_RS08065	COG0719	Fe-S assembly protein
H8F26_RS08070	COG0396	ATPase activity
H8F26_RS08075	COG0719	Fe-S assembly protein
H8F26_RS08080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8F26_RS08110	COG2197	response regulator
H8F26_RS08120	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8F26_RS08135	COG3347	Dehydrogenase
H8F26_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
H8F26_RS08200	COG0562	UDP-galactopyranose mutase
H8F26_RS08315	COG0242	peptide deformylase activity
H8F26_RS08330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H8F26_RS08345	COG0537	adenosine 5'-monophosphoramidase activity
H8F26_RS08350	COG4178	(ABC) transporter
H8F26_RS08370	COG0515	serine threonine protein kinase
H8F26_RS08385	COG0439	Biotin carboxylase
H8F26_RS08395	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F26_RS08400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F26_RS08410	COG1196	nuclear chromosome segregation
H8F26_RS08425	COG0116	Belongs to the methyltransferase superfamily
H8F26_RS08515	COG1196	nuclear chromosome segregation
H8F26_RS08550	COG1715	Restriction endonuclease
H8F26_RS08565	COG2602	Beta-lactamase
H8F26_RS08580	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H8F26_RS08655	COG4974	Belongs to the 'phage' integrase family
H8F26_RS08665	COG2337	Toxic component of a toxin-antitoxin (TA) module
H8F26_RS08685	COG3328	transposase activity
H8F26_RS08710	COG1484	DNA-dependent DNA replication
H8F26_RS08725	COG2755	lipolytic protein G-D-S-L family
H8F26_RS08725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8F26_RS08760	COG0667	Aldo Keto reductase
H8F26_RS08770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8F26_RS08775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8F26_RS08780	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8F26_RS08780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8F26_RS08785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8F26_RS08790	COG1413	lyase activity
H8F26_RS08810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8F26_RS08830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F26_RS08865	COG1070	Carbohydrate kinase
H8F26_RS08870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8F26_RS08880	COG0539	negative regulation of cytoplasmic translation
H8F26_RS08885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8F26_RS08910	COG0589	response to stress
H8F26_RS08920	COG0758	DNA mediated transformation
H8F26_RS08925	COG2890	protein-(glutamine-N5) methyltransferase activity
H8F26_RS08930	COG0009	L-threonylcarbamoyladenylate synthase
H8F26_RS08940	COG3706	GGDEF domain
H8F26_RS08960	COG3706	GGDEF domain
H8F26_RS08960	COG4251	negative regulation of phosphorylation
H8F26_RS08960	COG5001	Diguanylate cyclase
H8F26_RS08960	COG2203	Gaf domain
H8F26_RS08985	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8F26_RS08990	COG2894	cell division
H8F26_RS09005	COG2059	Chromate
H8F26_RS09010	COG0850	regulation of cytokinetic process
H8F26_RS09015	COG1078	dGTPase activity
H8F26_RS09020	COG0793	Belongs to the peptidase S41A family
H8F26_RS09025	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8F26_RS09030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8F26_RS09065	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8F26_RS09070	COG0235	Class ii aldolase
H8F26_RS09075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8F26_RS09090	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H8F26_RS09095	COG1653	transport
H8F26_RS09110	COG3842	ATPase activity
H8F26_RS09120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H8F26_RS09125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8F26_RS09130	COG0514	ATP-dependent DNA helicase (RecQ)
H8F26_RS09135	COG1388	LysM domain
H8F26_RS09135	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8F26_RS09140	COG1012	belongs to the aldehyde dehydrogenase family
H8F26_RS09150	COG2205	protein histidine kinase activity
H8F26_RS09150	COG0784	Response regulator, receiver
H8F26_RS09175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F26_RS09190	COG3328	transposase activity
H8F26_RS09230	COG3550	peptidyl-serine autophosphorylation
H8F26_RS09255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8F26_RS09255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F26_RS09260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8F26_RS09270	COG3328	transposase activity
H8F26_RS09345	COG0202	RNA polymerase activity
H8F26_RS09350	COG0443	Heat shock 70 kDa protein
H8F26_RS09360	COG2361	Protein of unknown function DUF86
H8F26_RS09370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F26_RS09450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F26_RS09465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F26_RS09545	COG3328	transposase activity
H8F26_RS09595	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F26_RS09620	COG0297	glycogen (starch) synthase activity
H8F26_RS09625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F26_RS09630	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8F26_RS09640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8F26_RS09650	COG0740	serine-type endopeptidase activity
H8F26_RS09655	COG0740	serine-type endopeptidase activity
H8F26_RS09660	COG4956	integral membrane protein (PIN domain superfamily)
H8F26_RS09665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8F26_RS09670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8F26_RS09680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H8F26_RS09695	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8F26_RS09700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F26_RS09705	COG2066	Belongs to the glutaminase family
H8F26_RS09705	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H8F26_RS09710	COG4948	Mandelate Racemase Muconate Lactonizing
H8F26_RS09750	COG0285	dihydrofolate synthase activity
H8F26_RS09755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8F26_RS09760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8F26_RS09765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8F26_RS09780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F26_RS09785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F26_RS09790	COG0134	indole-3-glycerol-phosphate synthase activity
H8F26_RS09795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H8F26_RS09800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8F26_RS09810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8F26_RS09815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8F26_RS09830	COG0306	phosphate transporter
H8F26_RS09850	COG0706	membrane insertase activity
H8F26_RS09860	COG0594	ribonuclease P activity
H8F26_RS09865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H8F26_RS09880	COG0616	signal peptide processing
H8F26_RS09885	COG0697	spore germination
H8F26_RS09890	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS09905	COG1842	Phage shock protein A
H8F26_RS09910	COG3118	belongs to the thioredoxin family
H8F26_RS09915	COG0436	Aminotransferase
H8F26_RS09920	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H8F26_RS09920	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H8F26_RS09925	COG0739	heme binding
H8F26_RS09930	COG1136	(ABC) transporter
H8F26_RS09940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8F26_RS09955	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8F26_RS09990	COG1845	cytochrome c oxidase, subunit III
H8F26_RS09995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8F26_RS10010	COG0109	protoheme IX farnesyltransferase activity
H8F26_RS10025	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H8F26_RS10030	COG0459	protein refolding
H8F26_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
H8F26_RS10045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8F26_RS10055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8F26_RS10065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F26_RS10080	COG0482	sulfurtransferase activity
H8F26_RS10085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8F26_RS10085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8F26_RS10090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F26_RS10095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8F26_RS10105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8F26_RS10115	COG1702	phosphate starvation-inducible protein PhoH
H8F26_RS10120	COG0670	Belongs to the BI1 family
H8F26_RS10130	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8F26_RS10140	COG0336	Belongs to the RNA methyltransferase TrmD family
H8F26_RS10150	COG1691	(AIR) carboxylase
H8F26_RS10170	COG0196	riboflavin kinase activity
H8F26_RS10180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8F26_RS10185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8F26_RS10190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8F26_RS10195	COG0745	RESPONSE REGULATOR receiver
H8F26_RS10210	COG0651	ATP synthesis coupled electron transport
H8F26_RS10260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F26_RS10260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F26_RS10265	COG0668	transmembrane transport
H8F26_RS10280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F26_RS10285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8F26_RS10290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8F26_RS10320	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8F26_RS10350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H8F26_RS10360	COG1185	polyribonucleotide nucleotidyltransferase activity
H8F26_RS10365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H8F26_RS10370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8F26_RS10375	COG0750	zinc metalloprotease
H8F26_RS10380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8F26_RS10385	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8F26_RS10435	COG0347	Belongs to the P(II) protein family
H8F26_RS10445	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8F26_RS10455	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F26_RS10460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F26_RS10470	COG0586	Pfam SNARE associated Golgi protein
H8F26_RS10475	COG2205	protein histidine kinase activity
H8F26_RS10485	COG1126	abc transporter atp-binding protein
H8F26_RS10490	COG0765	amino acid transport
H8F26_RS10495	COG4597	amino acid ABC transporter
H8F26_RS10500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8F26_RS10505	COG0530	calcium, potassium:sodium antiporter activity
H8F26_RS10510	COG0371	Dehydrogenase
H8F26_RS10515	COG0596	Alpha beta hydrolase
H8F26_RS10550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8F26_RS10560	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H8F26_RS10565	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H8F26_RS10570	COG0298	carbon dioxide binding
H8F26_RS10575	COG1013	pyruvate-flavodoxin oxidoreductase activity
H8F26_RS10575	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8F26_RS10575	COG0674	pyruvate-flavodoxin oxidoreductase activity
H8F26_RS10575	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H8F26_RS10580	COG0167	dihydroorotate dehydrogenase activity
H8F26_RS10585	COG0409	Hydrogenase expression formation protein
H8F26_RS10600	COG0579	oxidoreductase
H8F26_RS10610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8F26_RS10615	COG0739	heme binding
H8F26_RS10620	COG0723	plastoquinol--plastocyanin reductase activity
H8F26_RS10630	COG0805	protein transport
H8F26_RS10635	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H8F26_RS10640	COG0194	GDP metabolic process
H8F26_RS10655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8F26_RS10660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F26_RS10670	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H8F26_RS10680	COG0012	GTP binding
H8F26_RS10750	COG0601	transmembrane transport
H8F26_RS10765	COG0460	homoserine dehydrogenase
H8F26_RS10770	COG2166	iron-sulfur cluster assembly
H8F26_RS10785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8F26_RS10790	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8F26_RS10795	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F26_RS10815	COG2010	Cytochrome c
H8F26_RS10830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8F26_RS10835	COG1611	Belongs to the LOG family
H8F26_RS10840	COG3118	belongs to the thioredoxin family
H8F26_RS10845	COG0516	GMP reductase activity
H8F26_RS10860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8F26_RS10865	COG0644	oxidoreductase
H8F26_RS10870	COG1543	Belongs to the glycosyl hydrolase 57 family
H8F26_RS10880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8F26_RS10885	COG0395	ABC-type sugar transport system, permease component
H8F26_RS10905	COG1480	7TM receptor with intracellular HD hydrolase
H8F26_RS10920	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H8F26_RS10940	COG1254	Belongs to the acylphosphatase family
H8F26_RS10945	COG1797	cobyrinic acid a,c-diamide synthase activity
H8F26_RS10950	COG3429	Glucose-6-phosphate dehydrogenase subunit
H8F26_RS10950	COG3409	Peptidoglycan-binding domain 1 protein
H8F26_RS10955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8F26_RS10975	COG2205	protein histidine kinase activity
H8F26_RS10990	COG0308	aminopeptidase N
H8F26_RS11000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8F26_RS11015	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
H8F26_RS11020	COG1640	4-alpha-glucanotransferase
H8F26_RS11030	COG1187	pseudouridine synthase activity
H8F26_RS11035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F26_RS11045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F26_RS11050	COG1982	Orn Lys Arg decarboxylase major
H8F26_RS11055	COG2242	protein methyltransferase activity
H8F26_RS11055	COG2241	protein methyltransferase activity
H8F26_RS11060	COG0575	Belongs to the CDS family
H8F26_RS11090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F26_RS11105	COG0375	protein maturation
H8F26_RS11115	COG3259	Nickel-dependent hydrogenase
H8F26_RS11145	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F26_RS11200	COG0776	regulation of translation
H8F26_RS11210	COG1523	belongs to the glycosyl hydrolase 13 family
H8F26_RS11230	COG1215	transferase activity, transferring glycosyl groups
H8F26_RS11255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H8F26_RS11325	COG1064	alcohol dehydrogenase
H8F26_RS11330	COG1233	COG1233 Phytoene dehydrogenase and related
H8F26_RS11355	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8F26_RS11360	COG0271	Belongs to the BolA IbaG family
H8F26_RS11375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8F26_RS11390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8F26_RS11400	COG1074	ATP-dependent DNA helicase activity
H8F26_RS11405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F26_RS11415	COG0513	Belongs to the DEAD box helicase family
H8F26_RS11425	COG0724	RNA recognition motif
H8F26_RS11435	COG1132	(ABC) transporter
H8F26_RS11490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8F26_RS11495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8F26_RS11500	COG2205	protein histidine kinase activity
H8F26_RS11505	COG0745	RESPONSE REGULATOR receiver
H8F26_RS11520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F26_RS11525	COG3695	enzyme binding
H8F26_RS11530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F26_RS11530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8F26_RS11535	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8F26_RS11540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F26_RS11550	COG0107	imidazoleglycerol-phosphate synthase activity
H8F26_RS11560	COG2226	methyltransferase
H8F26_RS11565	COG0752	glycyl-tRNA synthetase alpha subunit
H8F26_RS11585	COG3328	transposase activity
H8F26_RS11620	COG3328	transposase activity
H8F26_RS11665	COG1484	DNA-dependent DNA replication
H8F26_RS11695	COG2192	nodulation
H8F26_RS11710	COG3328	transposase activity
H8F26_RS11795	COG3328	transposase activity
H8F26_RS11810	COG3328	transposase activity
H8F26_RS11840	COG0523	cobalamin synthesis protein
H8F26_RS11870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F26_RS11875	COG1121	(ABC) transporter
H8F26_RS11880	COG0803	Belongs to the bacterial solute-binding protein 9 family
H8F26_RS11885	COG0140	phosphoribosyl-ATP diphosphatase activity
H8F26_RS11885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8F26_RS11910	COG0523	cobalamin synthesis protein
H8F26_RS12010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F26_RS12020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F26_RS12040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F26_RS12065	COG0121	glutamine amidotransferase
H8F26_RS12080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8F26_RS12085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8F26_RS12135	COG2226	methyltransferase
H8F26_RS12140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F26_RS12160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F26_RS12180	COG1136	(ABC) transporter
H8F26_RS12180	COG0577	efflux transmembrane transporter activity
H8F26_RS12235	COG1484	DNA-dependent DNA replication
H8F26_RS12310	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H8F26_RS12320	COG3328	transposase activity
H8F26_RS12365	COG0500	methyltransferase
H8F26_RS12410	COG1054	Belongs to the UPF0176 family
H8F26_RS12415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8F26_RS12420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8F26_RS12425	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H8F26_RS12430	COG0019	diaminopimelate decarboxylase activity
H8F26_RS12440	COG0542	response to heat
H8F26_RS12495	COG0724	RNA recognition motif
H8F26_RS12515	COG0730	response to heat
H8F26_RS12520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8F26_RS12545	COG2326	polyphosphate kinase activity
H8F26_RS12570	COG0531	amino acid
H8F26_RS12595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F26_RS12655	COG2211	Major facilitator Superfamily
H8F26_RS12660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8F26_RS12675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H8F26_RS12680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8F26_RS12685	COG1799	cell septum assembly
H8F26_RS12690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8F26_RS12700	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H8F26_RS12705	COG1160	GTP binding
H8F26_RS12715	COG0477	Major facilitator Superfamily
H8F26_RS12730	COG3527	Alpha-acetolactate decarboxylase
H8F26_RS12735	COG0028	Belongs to the TPP enzyme family
H8F26_RS12750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F26_RS12760	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8F26_RS12765	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8F26_RS12765	COG2918	glutathione biosynthetic process
H8F26_RS12780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8F26_RS12795	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS12810	COG1381	Involved in DNA repair and RecF pathway recombination
H8F26_RS12815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H8F26_RS12820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8F26_RS12825	COG0321	lipoyl(octanoyl) transferase activity
H8F26_RS12830	COG1022	Amp-dependent synthetase and ligase
H8F26_RS12845	COG0531	amino acid
H8F26_RS12850	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8F26_RS12855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8F26_RS12870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H8F26_RS12875	COG1492	cobalamin metabolic process
H8F26_RS12885	COG0424	maF-like protein
H8F26_RS12910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F26_RS12915	COG0440	acetolactate synthase activity
H8F26_RS12920	COG2267	carboxylic ester hydrolase activity
H8F26_RS12925	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H8F26_RS12970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H8F26_RS12975	COG0492	ferredoxin-NADP+ reductase activity
H8F26_RS13000	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8F26_RS13025	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8F26_RS13035	COG0733	neurotransmitter:sodium symporter activity
H8F26_RS13090	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS13090	COG1216	Glycosyl transferase, family 2
H8F26_RS13115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F26_RS13120	COG0463	Glycosyl transferase, family 2
H8F26_RS13125	COG1216	Glycosyl transferase, family 2
H8F26_RS13125	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS13145	COG2089	acid synthase
H8F26_RS13150	COG1083	cytidylyl-transferase
H8F26_RS13200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8F26_RS13215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8F26_RS13285	COG0531	amino acid
H8F26_RS13355	COG3093	addiction module antidote protein HigA
H8F26_RS13370	COG2337	Toxic component of a toxin-antitoxin (TA) module
H8F26_RS13400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H8F26_RS13470	COG3093	addiction module antidote protein HigA
H8F26_RS13520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8F26_RS13535	COG0733	neurotransmitter:sodium symporter activity
H8F26_RS13555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F26_RS13580	COG3754	Rhamnan synthesis protein F
H8F26_RS13590	COG0489	protein tyrosine kinase activity
H8F26_RS13640	COG1132	(ABC) transporter
H8F26_RS13690	COG3328	transposase activity
H8F26_RS13705	COG3328	transposase activity
H8F26_RS13730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F26_RS13735	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS13740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8F26_RS13810	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS13830	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS13855	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS13890	COG0438	transferase activity, transferring glycosyl groups
H8F26_RS13950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F26_RS14010	COG0215	cysteine-tRNA ligase activity
H8F26_RS14015	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H8F26_RS14020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F26_RS14030	COG0475	glutathione-regulated potassium exporter activity
H8F26_RS14030	COG0589	response to stress
H8F26_RS14065	COG0367	asparagine synthase
H8F26_RS14070	COG0540	Belongs to the ATCase OTCase family
H8F26_RS14100	COG0799	negative regulation of ribosome biogenesis
H8F26_RS14110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8F26_RS14135	COG1132	(ABC) transporter
H8F26_RS14140	COG2501	S4 domain
H8F26_RS14145	COG0149	triose-phosphate isomerase activity
H8F26_RS14150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8F26_RS14165	COG1132	(ABC) transporter
H8F26_RS14195	COG0745	RESPONSE REGULATOR receiver
H8F26_RS14200	COG1429	ligase activity, forming nitrogen-metal bonds
H8F26_RS14205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8F26_RS14215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F26_RS14220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8F26_RS14230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8F26_RS14255	COG2326	polyphosphate kinase activity
H8F26_RS14300	COG0598	Magnesium transport protein CorA
H8F26_RS14320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F26_RS14325	COG0745	RESPONSE REGULATOR receiver
H8F26_RS14330	COG5002	protein histidine kinase activity
H8F26_RS14335	COG0659	secondary active sulfate transmembrane transporter activity
H8F26_RS14345	COG0659	secondary active sulfate transmembrane transporter activity
H8F26_RS14350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8F26_RS14365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F26_RS14370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F26_RS14390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8F26_RS14430	COG3128	pkhd-type hydroxylase
H8F26_RS14440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8F26_RS14455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8F26_RS14470	COG2199	diguanylate cyclase activity
H8F26_RS14480	COG0358	DNA primase activity
H8F26_RS14495	COG0632	four-way junction helicase activity
H8F26_RS14500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8F26_RS14510	COG0587	DNA-directed DNA polymerase activity
H8F26_RS14515	COG0154	amidase activity
H8F26_RS14530	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H8F26_RS14540	COG0505	Belongs to the CarA family
H8F26_RS14545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8F26_RS14555	COG1132	(ABC) transporter
H8F26_RS14565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F26_RS14615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F26_RS14670	COG2326	polyphosphate kinase activity
H8F26_RS14680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8F26_RS14685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8F26_RS14700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F26_RS14725	COG0142	geranyltranstransferase activity
H8F26_RS14730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H8F26_RS14745	COG2045	Belongs to the ComB family
H8F26_RS14750	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H8F26_RS14755	COG1959	2 iron, 2 sulfur cluster binding
H8F26_RS14765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8F26_RS14770	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H8F26_RS14770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F26_RS14775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F26_RS14785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8F26_RS14795	COG0297	glycogen (starch) synthase activity
H8F26_RS14800	COG1376	ErfK ybiS ycfS ynhG family protein
H8F26_RS14805	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H8F26_RS14810	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H8F26_RS14815	COG0681	Belongs to the peptidase S26 family
H8F26_RS14830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F26_RS14835	COG1121	(ABC) transporter
H8F26_RS14840	COG0803	Belongs to the bacterial solute-binding protein 9 family
H8F26_RS14870	COG0180	Tryptophanyl-tRNA synthetase
H8F26_RS14890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8F26_RS14895	COG0837	glucose binding
H8F26_RS14900	COG0083	homoserine kinase activity
H8F26_RS14905	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F26_RS14910	COG0339	signal peptide processing
H8F26_RS14925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8F26_RS14930	COG1940	carbohydrate kinase activity
H8F26_RS14965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8F26_RS14970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8F26_RS14980	COG2010	Cytochrome c
H8F26_RS15005	COG0542	response to heat
H8F26_RS15010	COG0432	Pfam Uncharacterised protein family UPF0047
H8F26_RS15025	COG1283	sodium-dependent phosphate transmembrane transporter activity
H8F26_RS15055	COG1741	Belongs to the pirin family
H8F26_RS15060	COG0281	malic enzyme
H8F26_RS15085	COG4942	peptidase
H8F26_RS15095	COG0347	Belongs to the P(II) protein family
H8F26_RS15100	COG0004	ammonium transporteR
H8F26_RS15115	COG0792	nuclease activity
H8F26_RS15125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8F26_RS15130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8F26_RS15140	COG0022	dehydrogenase e1 component
H8F26_RS15145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8F26_RS15150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8F26_RS15165	COG0628	permease
H8F26_RS15170	COG3310	Protein conserved in bacteria
H8F26_RS15175	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H8F26_RS15180	COG0515	serine threonine protein kinase
H8F26_RS15200	COG2226	methyltransferase
H8F26_RS15205	COG0174	glutamine synthetase
H8F26_RS15215	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8F26_RS15220	COG0590	tRNA wobble adenosine to inosine editing
H8F26_RS15220	COG0037	tRNA processing
H8F26_RS15235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8F26_RS15240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8F26_RS15260	COG0612	Peptidase, M16
H8F26_RS15280	COG1136	(ABC) transporter
H8F26_RS15290	COG1216	Glycosyl transferase, family 2
H8F26_RS15295	COG0052	Belongs to the universal ribosomal protein uS2 family
H8F26_RS15300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8F26_RS15310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8F26_RS15315	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8F26_RS15325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F26_RS15330	COG0751	glycine-tRNA ligase activity
H8F26_RS15335	COG0644	oxidoreductase
H8F26_RS15345	COG0826	peptidase U32
H8F26_RS15350	COG1217	gtp-binding protein TYPA
H8F26_RS15365	COG1137	ATPase activity
H8F26_RS15375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8F26_RS15380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H8F26_RS15385	COG1494	fructose-1,6-bisphosphatase
H8F26_RS15390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8F26_RS15395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F26_RS15400	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H8F26_RS15405	COG0363	glucosamine-6-phosphate deaminase activity
H8F26_RS15420	COG0129	dihydroxy-acid dehydratase activity
H8F26_RS15430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8F26_RS15455	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8F26_RS15460	COG0047	phosphoribosylformylglycinamidine synthase activity
H8F26_RS15465	COG1619	proteins homologs of microcin C7 resistance protein MccF
H8F26_RS15470	COG0450	alkyl hydroperoxide reductase
H8F26_RS15490	COG0484	heat shock protein binding
H8F26_RS15495	COG0076	glutamate decarboxylase activity
H8F26_RS15500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F26_RS15505	COG0640	Transcriptional regulator
H8F26_RS15635	COG1484	DNA-dependent DNA replication
H8F26_RS15700	COG0318	PFAM AMP-dependent synthetase and ligase
H8F26_RS15740	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
H8F26_RS15845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8F26_RS15870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F26_RS15875	COG1487	ribonuclease activity
H8F26_RS15895	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H8F26_RS15955	COG1484	DNA-dependent DNA replication
H8F26_RS15990	COG2361	Protein of unknown function DUF86
H8F26_RS16025	COG1487	ribonuclease activity
H8F26_RS16115	COG2105	PFAM AIG2 family protein
H8F26_RS16160	COG3328	transposase activity
H8F26_RS16165	COG0288	reversible hydration of carbon dioxide
H8F26_RS16265	COG1484	DNA-dependent DNA replication
H8F26_RS16335	COG0582	viral genome integration into host DNA
H8F26_RS16345	COG0739	heme binding
H8F26_RS16350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8F26_RS16385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F26_RS16400	COG0557	exoribonuclease II activity
H8F26_RS16405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8F26_RS16410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H8F26_RS16415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F26_RS16415	COG0072	phenylalanine-tRNA ligase activity
H8F26_RS16420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8F26_RS16450	COG2385	sporulation resulting in formation of a cellular spore
H8F26_RS16460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8F26_RS16485	COG0646	methionine synthase
H8F26_RS16485	COG1410	methionine synthase
H8F26_RS16490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8F26_RS16510	COG1981	membrane
H8F26_RS16540	COG0641	radical SAM
H8F26_RS16570	COG3046	protein related to deoxyribodipyrimidine photolyase
H8F26_RS16580	COG0322	excinuclease ABC activity
H8F26_RS16590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8F26_RS16600	COG2027	D-alanyl-D-alanine carboxypeptidase
H8F26_RS16615	COG1104	cysteine desulfurase activity
H8F26_RS16620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8F26_RS16630	COG0495	leucyl-tRNA aminoacylation
H8F26_RS16635	COG0166	Belongs to the GPI family
H8F26_RS16660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8F26_RS16665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8F26_RS16670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8F26_RS16670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8F26_RS16675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F26_RS16680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8F26_RS16695	COG0484	heat shock protein binding
H8F26_RS16700	COG0443	Heat shock 70 kDa protein
H8F26_RS16705	COG0573	inorganic phosphate transmembrane transporter activity
H8F26_RS16710	COG0581	inorganic phosphate transmembrane transporter activity
H8F26_RS16715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8F26_RS16730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F26_RS16735	COG0483	inositol monophosphate 1-phosphatase activity
H8F26_RS16740	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H8F26_RS16755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H8F26_RS16760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F26_RS16800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8F26_RS16805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8F26_RS16835	COG0469	pyruvate kinase activity
H8F26_RS16840	COG1136	(ABC) transporter
H8F26_RS16840	COG0577	efflux transmembrane transporter activity
H8F26_RS16850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F26_RS16855	COG0740	serine-type endopeptidase activity
H8F26_RS16875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8F26_RS16905	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H8F26_RS16910	COG1175	transmembrane transport
H8F26_RS16915	COG0514	ATP-dependent DNA helicase (RecQ)
H8F26_RS16920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8F26_RS16960	COG3588	fructose-bisphosphate aldolase
H8F26_RS16965	COG1793	dna ligase
H8F26_RS16965	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8F26_RS16980	COG0778	Nitroreductase
H8F26_RS17030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F26_RS17050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F26_RS17120	COG5398	heme oxygenase
H8F26_RS17160	COG3328	transposase activity
H8F26_RS17175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8F26_RS17195	COG0861	Integral membrane protein TerC family
H8F26_RS17205	COG0513	Belongs to the DEAD box helicase family
H8F26_RS17225	COG1252	NADH dehydrogenase
H8F26_RS17230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8F26_RS17240	COG0312	modulator of DNA gyrase
H8F26_RS17245	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H8F26_RS17260	COG0163	prenyltransferase activity
H8F26_RS17265	COG0557	exoribonuclease II activity
H8F26_RS17290	COG3300	MHYT domain
H8F26_RS17290	COG5001	Diguanylate cyclase
H8F26_RS17310	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H8F26_RS17310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8F26_RS17325	COG1132	(ABC) transporter
H8F26_RS17330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8F26_RS17335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F26_RS17350	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8F26_RS17355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8F26_RS17365	COG0191	fructose-bisphosphate aldolase activity
H8F26_RS17370	COG0673	inositol 2-dehydrogenase activity
H8F26_RS17380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8F26_RS17385	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8F26_RS17395	COG3954	Phosphoribulokinase
H8F26_RS17400	COG0473	3-isopropylmalate dehydrogenase activity
H8F26_RS17405	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F26_RS17410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8F26_RS17425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8F26_RS17440	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8F26_RS17460	COG3328	transposase activity
H8F26_RS17470	COG3447	MASE1 domain protein
H8F26_RS17470	COG5001	Diguanylate cyclase
H8F26_RS17470	COG5002	protein histidine kinase activity
H8F26_RS17475	COG0114	fumarate hydratase activity
H8F26_RS17480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8F26_RS17485	COG2197	response regulator
H8F26_RS17495	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8F26_RS17515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8F26_RS17550	COG1201	RNA secondary structure unwinding
H8F26_RS17555	COG1793	dna ligase
H8F26_RS17555	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8F26_RS17560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F26_RS17585	COG0577	efflux transmembrane transporter activity
H8F26_RS17585	COG1136	(ABC) transporter
H8F26_RS17610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8F26_RS17660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8F26_RS17695	COG3328	transposase activity
H8F26_RS17705	COG2112	serine threonine protein kinase
H8F26_RS17795	COG2234	aminopeptidase activity
H8F26_RS17830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F26_RS17835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F26_RS17855	COG1793	dna ligase
H8F26_RS17985	COG0159	tryptophan synthase activity
H8F26_RS18005	COG2010	Cytochrome c
H8F26_RS18045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F26_RS18060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F26_RS18065	COG1121	(ABC) transporter
H8F26_RS18080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8F26_RS18080	COG0140	phosphoribosyl-ATP diphosphatase activity
H8F26_RS18085	COG0720	synthase
H8F26_RS18090	COG0701	Predicted permease
H8F26_RS18110	COG3659	wide pore channel activity
H8F26_RS18125	COG0784	Response regulator, receiver
H8F26_RS18125	COG4191	Histidine kinase
H8F26_RS18130	COG3706	GGDEF domain
H8F26_RS18140	COG0523	cobalamin synthesis protein
H8F26_RS18155	COG1840	ABC-type Fe3 transport system, periplasmic component
H8F26_RS18175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F26_RS18180	COG0735	belongs to the Fur family
H8F26_RS18210	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H8F26_RS18215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F26_RS18235	COG0708	Exodeoxyribonuclease III
H8F26_RS18245	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8F26_RS18250	COG4251	negative regulation of phosphorylation
H8F26_RS18265	COG2119	membrane
H8F26_RS18275	COG1116	anion transmembrane transporter activity
H8F26_RS18280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8F26_RS18300	COG0375	protein maturation
H8F26_RS18305	COG0010	Belongs to the arginase family
H8F26_RS18325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8F26_RS18340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F26_RS18340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F26_RS18355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8F26_RS18370	COG0335	large ribosomal subunit rRNA binding
H8F26_RS18380	COG0024	Methionine aminopeptidase
H8F26_RS18385	COG0300	oxidoreductase activity
H8F26_RS18385	COG3000	fatty acid hydroxylase
H8F26_RS18395	COG0857	belongs to the CobB CobQ family
H8F26_RS18410	COG0330	HflC and HflK could
H8F26_RS18430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F26_RS18440	COG1666	GTP binding
H8F26_RS18490	COG0405	Gamma-glutamyltransferase
H8F26_RS18520	COG1845	cytochrome c oxidase, subunit III
H8F26_RS18595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8F26_RS18600	COG0277	FAD linked oxidase domain protein
H8F26_RS18650	COG1484	DNA-dependent DNA replication
H8F26_RS18680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8F26_RS18685	COG4106	trans-aconitate 2-methyltransferase activity
H8F26_RS18705	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8F26_RS18720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8F26_RS18725	COG1122	ATPase activity
H8F26_RS18745	COG1836	PFAM Integral membrane protein DUF92
H8F26_RS18750	COG1191	sigma factor activity
H8F26_RS18760	COG3639	organic phosphonate transmembrane transporter activity
H8F26_RS18765	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H8F26_RS18785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8F26_RS18805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H8F26_RS18810	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H8F26_RS18820	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H8F26_RS18825	COG0436	Aminotransferase
H8F26_RS18835	COG3328	transposase activity
H8F26_RS18850	COG1573	uracil-dna glycosylase
H8F26_RS18865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8F26_RS18870	COG0793	Belongs to the peptidase S41A family
H8F26_RS18885	COG1269	ATP hydrolysis coupled proton transport
H8F26_RS18905	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
H8F26_RS18915	COG0668	transmembrane transport
H8F26_RS18920	COG3264	Mechanosensitive ion channel
H8F26_RS18920	COG1196	nuclear chromosome segregation
H8F26_RS18935	COG2124	cytochrome p450
H8F26_RS18940	COG2124	cytochrome p450
H8F26_RS18960	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H8F26_RS19005	COG1230	cation diffusion facilitator family transporter
H8F26_RS19010	COG0300	oxidoreductase activity
H8F26_RS19025	COG0284	orotidine-5'-phosphate decarboxylase activity
H8F26_RS19025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8F26_RS19030	COG0418	dihydroorotase activity
H8F26_RS19040	COG0251	oxidation-reduction process
H8F26_RS19045	COG3842	ATPase activity
H8F26_RS19050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8F26_RS19055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8F26_RS19060	COG1132	(ABC) transporter
H8F26_RS19070	COG0456	acetyltransferase
H8F26_RS19075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain