locus-tag	class	description
I1E95_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I1E95_RS00010	COG0464	growth
I1E95_RS00025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_RS00030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I1E95_RS00040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1E95_RS00065	COG4451	ribulose bisphosphate carboxylase, small
I1E95_RS00070	COG1850	ribulose-bisphosphate carboxylase activity
I1E95_RS00075	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1E95_RS00080	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
I1E95_RS00085	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
I1E95_RS00090	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
I1E95_RS00130	COG0730	response to heat
I1E95_RS00135	COG0095	Lipoate-protein ligase
I1E95_RS00140	COG1994	Peptidase M50
I1E95_RS00140	COG0517	IMP dehydrogenase activity
I1E95_RS00145	COG0135	phosphoribosylanthranilate isomerase activity
I1E95_RS00155	COG4221	oxidoreductase activity
I1E95_RS00160	COG0825	malonyl-CoA metabolic process
I1E95_RS00165	COG5322	oxidoreductase activity
I1E95_RS00170	COG3396	Phenylacetate-CoA oxygenase
I1E95_RS00180	COG0539	negative regulation of cytoplasmic translation
I1E95_RS00195	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I1E95_RS00210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1E95_RS00215	COG0745	RESPONSE REGULATOR receiver
I1E95_RS00245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I1E95_RS00250	COG0530	calcium, potassium:sodium antiporter activity
I1E95_RS00255	COG0659	secondary active sulfate transmembrane transporter activity
I1E95_RS00260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_RS00270	COG0523	cobalamin synthesis protein
I1E95_RS00275	COG3659	wide pore channel activity
I1E95_RS00300	COG2132	Multicopper oxidase
I1E95_RS00310	COG1121	(ABC) transporter
I1E95_RS00315	COG3328	transposase activity
I1E95_RS00325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1E95_RS00340	COG0701	Predicted permease
I1E95_RS00350	COG0140	phosphoribosyl-ATP diphosphatase activity
I1E95_RS00350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I1E95_RS00370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_RS00375	COG3339	Conserved Protein
I1E95_RS00410	COG2010	Cytochrome c
I1E95_RS00440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I1E95_RS00450	COG0159	tryptophan synthase activity
I1E95_RS00480	COG3328	transposase activity
I1E95_RS00485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1E95_RS00485	COG0300	oxidoreductase activity
I1E95_RS00485	COG3321	synthase
I1E95_RS00485	COG4221	oxidoreductase activity
I1E95_RS00495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I1E95_RS00505	COG0242	peptide deformylase activity
I1E95_RS00515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1E95_RS00520	COG0463	Glycosyl transferase, family 2
I1E95_RS00535	COG0415	Belongs to the DNA photolyase family
I1E95_RS00545	COG0659	secondary active sulfate transmembrane transporter activity
I1E95_RS00610	COG2226	methyltransferase
I1E95_RS00615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I1E95_RS00630	COG0668	transmembrane transport
I1E95_RS00665	COG3328	transposase activity
I1E95_RS00700	COG0586	Pfam SNARE associated Golgi protein
I1E95_RS00720	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1E95_RS00725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I1E95_RS00770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_RS00775	COG1231	oxidoreductase activity
I1E95_RS00805	COG0786	glutamate:sodium symporter activity
I1E95_RS00810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I1E95_RS00830	COG0739	heme binding
I1E95_RS00860	COG1054	Belongs to the UPF0176 family
I1E95_RS00865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I1E95_RS00870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I1E95_RS00875	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I1E95_RS00880	COG0019	diaminopimelate decarboxylase activity
I1E95_RS00890	COG0542	response to heat
I1E95_RS00895	COG0371	Dehydrogenase
I1E95_RS00900	COG0596	Alpha beta hydrolase
I1E95_RS00900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I1E95_RS00900	COG2226	methyltransferase
I1E95_RS00915	COG0575	Belongs to the CDS family
I1E95_RS00925	COG1982	Orn Lys Arg decarboxylase major
I1E95_RS00930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1E95_RS00950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_RS00955	COG1187	pseudouridine synthase activity
I1E95_RS00965	COG1640	4-alpha-glucanotransferase
I1E95_RS00970	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
I1E95_RS00985	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I1E95_RS00995	COG0308	aminopeptidase N
I1E95_RS01015	COG2205	protein histidine kinase activity
I1E95_RS01035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I1E95_RS01040	COG3429	Glucose-6-phosphate dehydrogenase subunit
I1E95_RS01040	COG3409	Peptidoglycan-binding domain 1 protein
I1E95_RS01045	COG1797	cobyrinic acid a,c-diamide synthase activity
I1E95_RS01050	COG1254	Belongs to the acylphosphatase family
I1E95_RS01075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I1E95_RS01080	COG1480	7TM receptor with intracellular HD hydrolase
I1E95_RS01085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_RS01120	COG0799	negative regulation of ribosome biogenesis
I1E95_RS01130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I1E95_RS01150	COG1132	(ABC) transporter
I1E95_RS01160	COG0149	triose-phosphate isomerase activity
I1E95_RS01165	COG0277	FAD linked oxidase domain protein
I1E95_RS01170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I1E95_RS01180	COG0559	Belongs to the binding-protein-dependent transport system permease family
I1E95_RS01210	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I1E95_RS01215	COG2045	Belongs to the ComB family
I1E95_RS01230	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I1E95_RS01235	COG0142	geranyltranstransferase activity
I1E95_RS01255	COG4106	trans-aconitate 2-methyltransferase activity
I1E95_RS01345	COG3046	protein related to deoxyribodipyrimidine photolyase
I1E95_RS01365	COG3328	transposase activity
I1E95_RS01385	COG1881	PFAM PEBP family protein
I1E95_RS01485	COG3328	transposase activity
I1E95_RS01490	COG5002	protein histidine kinase activity
I1E95_RS01505	COG3588	fructose-bisphosphate aldolase
I1E95_RS01525	COG1793	dna ligase
I1E95_RS01525	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I1E95_RS01595	COG1793	dna ligase
I1E95_RS01605	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I1E95_RS01625	COG1201	RNA secondary structure unwinding
I1E95_RS01655	COG3829	transcription factor binding
I1E95_RS01660	COG0625	glutathione transferase activity
I1E95_RS01675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I1E95_RS01690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I1E95_RS01700	COG2197	response regulator
I1E95_RS01705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1E95_RS01710	COG0114	fumarate hydratase activity
I1E95_RS01730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I1E95_RS01745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I1E95_RS01760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I1E95_RS01765	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I1E95_RS01770	COG0473	3-isopropylmalate dehydrogenase activity
I1E95_RS01775	COG3954	Phosphoribulokinase
I1E95_RS01785	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I1E95_RS01790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I1E95_RS01800	COG0673	inositol 2-dehydrogenase activity
I1E95_RS01805	COG0191	fructose-bisphosphate aldolase activity
I1E95_RS01815	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I1E95_RS01820	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I1E95_RS01830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_RS01835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I1E95_RS01850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1E95_RS01855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I1E95_RS01855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I1E95_RS01870	COG2119	membrane
I1E95_RS01880	COG0557	exoribonuclease II activity
I1E95_RS01885	COG0163	prenyltransferase activity
I1E95_RS01900	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I1E95_RS01905	COG0312	modulator of DNA gyrase
I1E95_RS01915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I1E95_RS01920	COG2326	polyphosphate kinase activity
I1E95_RS01945	COG1269	ATP hydrolysis coupled proton transport
I1E95_RS01965	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I1E95_RS01970	COG0513	Belongs to the DEAD box helicase family
I1E95_RS01995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1E95_RS02000	COG0281	malic enzyme
I1E95_RS02005	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I1E95_RS02095	COG0443	Heat shock 70 kDa protein
I1E95_RS02115	COG3328	transposase activity
I1E95_RS02130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_RS02145	COG3328	transposase activity
I1E95_RS02190	COG3328	transposase activity
I1E95_RS02235	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I1E95_RS02240	COG1233	COG1233 Phytoene dehydrogenase and related
I1E95_RS02265	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I1E95_RS02270	COG0271	Belongs to the BolA IbaG family
I1E95_RS02285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I1E95_RS02305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I1E95_RS02310	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I1E95_RS02320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1E95_RS02340	COG0513	Belongs to the DEAD box helicase family
I1E95_RS02355	COG0724	RNA recognition motif
I1E95_RS02360	COG1132	(ABC) transporter
I1E95_RS02385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I1E95_RS02390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I1E95_RS02425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1E95_RS02430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1E95_RS02445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1E95_RS02450	COG2176	DNA-directed DNA polymerase activity
I1E95_RS02460	COG1283	sodium-dependent phosphate transmembrane transporter activity
I1E95_RS02470	COG0598	Magnesium transport protein CorA
I1E95_RS02520	COG1122	ATPase activity
I1E95_RS02530	COG1064	alcohol dehydrogenase
I1E95_RS02570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_RS02580	COG3848	Pyruvate phosphate dikinase
I1E95_RS02580	COG0574	Belongs to the PEP-utilizing enzyme family
I1E95_RS02590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_RS02590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1E95_RS02595	COG2326	polyphosphate kinase activity
I1E95_RS02600	COG0300	oxidoreductase activity
I1E95_RS02605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1E95_RS02615	COG1132	(ABC) transporter
I1E95_RS02625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I1E95_RS02630	COG0505	Belongs to the CarA family
I1E95_RS02640	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I1E95_RS02645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1E95_RS02655	COG0154	amidase activity
I1E95_RS02660	COG0587	DNA-directed DNA polymerase activity
I1E95_RS02670	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I1E95_RS02675	COG0632	four-way junction helicase activity
I1E95_RS02685	COG0076	glutamate decarboxylase activity
I1E95_RS02695	COG0358	DNA primase activity
I1E95_RS02765	COG0069	glutamate synthase activity
I1E95_RS02785	COG1484	DNA-dependent DNA replication
I1E95_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
I1E95_RS02840	COG2890	protein-(glutamine-N5) methyltransferase activity
I1E95_RS02855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I1E95_RS02860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I1E95_RS02875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I1E95_RS02900	COG1836	PFAM Integral membrane protein DUF92
I1E95_RS02915	COG3639	organic phosphonate transmembrane transporter activity
I1E95_RS02920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1E95_RS02920	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I1E95_RS02930	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I1E95_RS02935	COG0436	Aminotransferase
I1E95_RS02940	COG1573	uracil-dna glycosylase
I1E95_RS02945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I1E95_RS02950	COG0793	Belongs to the peptidase S41A family
I1E95_RS02960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I1E95_RS02975	COG0861	Integral membrane protein TerC family
I1E95_RS02985	COG2119	membrane
I1E95_RS03000	COG0395	ABC-type sugar transport system, permease component
I1E95_RS03005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1E95_RS03015	COG1543	Belongs to the glycosyl hydrolase 57 family
I1E95_RS03025	COG0589	response to stress
I1E95_RS03030	COG0644	oxidoreductase
I1E95_RS03035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I1E95_RS03050	COG0516	GMP reductase activity
I1E95_RS03055	COG3118	belongs to the thioredoxin family
I1E95_RS03060	COG1611	Belongs to the LOG family
I1E95_RS03065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I1E95_RS03080	COG2010	Cytochrome c
I1E95_RS03085	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I1E95_RS03100	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I1E95_RS03105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I1E95_RS03110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I1E95_RS03125	COG2166	iron-sulfur cluster assembly
I1E95_RS03130	COG0460	homoserine dehydrogenase
I1E95_RS03140	COG0747	negative chemotaxis
I1E95_RS03145	COG0601	transmembrane transport
I1E95_RS03170	COG0012	GTP binding
I1E95_RS03180	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I1E95_RS03190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_RS03195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I1E95_RS03210	COG0194	GDP metabolic process
I1E95_RS03215	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I1E95_RS03220	COG0805	protein transport
I1E95_RS03230	COG0723	plastoquinol--plastocyanin reductase activity
I1E95_RS03235	COG0739	heme binding
I1E95_RS03240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I1E95_RS03260	COG0248	Ppx GppA phosphatase
I1E95_RS03265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I1E95_RS03275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I1E95_RS03290	COG1028	Short-chain dehydrogenase reductase Sdr
I1E95_RS03300	COG0459	protein refolding
I1E95_RS03305	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I1E95_RS03325	COG0109	protoheme IX farnesyltransferase activity
I1E95_RS03340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I1E95_RS03345	COG1845	cytochrome c oxidase, subunit III
I1E95_RS03380	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I1E95_RS03395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I1E95_RS03400	COG1007	ATP synthesis coupled electron transport
I1E95_RS03405	COG0577	efflux transmembrane transporter activity
I1E95_RS03405	COG1136	(ABC) transporter
I1E95_RS03410	COG0739	heme binding
I1E95_RS03415	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I1E95_RS03415	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I1E95_RS03420	COG0436	Aminotransferase
I1E95_RS03425	COG3118	belongs to the thioredoxin family
I1E95_RS03430	COG1842	Phage shock protein A
I1E95_RS03445	COG0438	transferase activity, transferring glycosyl groups
I1E95_RS03450	COG0697	spore germination
I1E95_RS03455	COG0616	signal peptide processing
I1E95_RS03470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I1E95_RS03475	COG0594	ribonuclease P activity
I1E95_RS03485	COG0706	membrane insertase activity
I1E95_RS03495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_RS03500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I1E95_RS03505	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I1E95_RS03525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I1E95_RS03530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I1E95_RS03545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I1E95_RS03555	COG0134	indole-3-glycerol-phosphate synthase activity
I1E95_RS03560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1E95_RS03565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1E95_RS03580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I1E95_RS03585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I1E95_RS03590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I1E95_RS03595	COG0285	dihydrofolate synthase activity
I1E95_RS03610	COG1228	amidohydrolase
I1E95_RS03630	COG4948	Mandelate Racemase Muconate Lactonizing
I1E95_RS03635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1E95_RS03640	COG1181	Belongs to the D-alanine--D-alanine ligase family
I1E95_RS03655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I1E95_RS03665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I1E95_RS03670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I1E95_RS03675	COG4956	integral membrane protein (PIN domain superfamily)
I1E95_RS03680	COG0740	serine-type endopeptidase activity
I1E95_RS03685	COG0740	serine-type endopeptidase activity
I1E95_RS03700	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I1E95_RS03705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I1E95_RS03785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I1E95_RS03795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1E95_RS03800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_RS03810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I1E95_RS03815	COG1429	ligase activity, forming nitrogen-metal bonds
I1E95_RS03820	COG0435	Glutathione S-transferase
I1E95_RS03825	COG0778	Nitroreductase
I1E95_RS03830	COG1028	Short-chain dehydrogenase reductase Sdr
I1E95_RS03835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I1E95_RS03840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1E95_RS03850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I1E95_RS03865	COG1649	PFAM Uncharacterised BCR, COG1649
I1E95_RS03870	COG1959	2 iron, 2 sulfur cluster binding
I1E95_RS03890	COG0842	Transport permease protein
I1E95_RS03895	COG1129	ABC transporter
I1E95_RS03895	COG0842	Transport permease protein
I1E95_RS03900	COG1131	(ABC) transporter
I1E95_RS03905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I1E95_RS03920	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I1E95_RS03935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I1E95_RS03940	COG1136	(ABC) transporter
I1E95_RS03945	COG1136	(ABC) transporter
I1E95_RS03945	COG0577	efflux transmembrane transporter activity
I1E95_RS03950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I1E95_RS03955	COG0531	amino acid
I1E95_RS03980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1E95_RS04010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1E95_RS04035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I1E95_RS04050	COG0318	PFAM AMP-dependent synthetase and ligase
I1E95_RS04075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1E95_RS04180	COG0723	plastoquinol--plastocyanin reductase activity
I1E95_RS04220	COG3328	transposase activity
I1E95_RS04230	COG1872	DUF167
I1E95_RS04265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I1E95_RS04365	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I1E95_RS04505	COG3328	transposase activity
I1E95_RS04550	COG3328	transposase activity
I1E95_RS04630	COG3328	transposase activity
I1E95_RS04655	COG0582	viral genome integration into host DNA
I1E95_RS04665	COG3237	CsbD-like
I1E95_RS04675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1E95_RS04695	COG0752	glycyl-tRNA synthetase alpha subunit
I1E95_RS04720	COG2226	methyltransferase
I1E95_RS04730	COG0107	imidazoleglycerol-phosphate synthase activity
I1E95_RS04740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I1E95_RS04745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I1E95_RS04750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I1E95_RS04750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I1E95_RS04755	COG3695	enzyme binding
I1E95_RS04760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1E95_RS04765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1E95_RS04780	COG0714	Associated with various cellular activities
I1E95_RS04850	COG3328	transposase activity
I1E95_RS04860	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1E95_RS04865	COG3657	addiction module killer protein
I1E95_RS04885	COG2226	methyltransferase
I1E95_RS04900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I1E95_RS04905	COG0719	Fe-S assembly protein
I1E95_RS04910	COG0396	ATPase activity
I1E95_RS04915	COG0719	Fe-S assembly protein
I1E95_RS04920	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
I1E95_RS04945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I1E95_RS04980	COG0033	Phosphoglucomutase
I1E95_RS05005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I1E95_RS05030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1E95_RS05035	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I1E95_RS05040	COG0175	sulfate reduction
I1E95_RS05045	COG1252	NADH dehydrogenase
I1E95_RS05055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I1E95_RS05060	COG0471	metal ion transport
I1E95_RS05060	COG3273	potassium ion transport
I1E95_RS05065	COG0450	alkyl hydroperoxide reductase
I1E95_RS05070	COG0569	domain protein
I1E95_RS05075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I1E95_RS05100	COG0488	(ABC) transporter
I1E95_RS05115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1E95_RS05130	COG1643	Atp-dependent helicase
I1E95_RS05135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_RS05145	COG1570	exodeoxyribonuclease VII activity
I1E95_RS05200	COG0483	inositol monophosphate 1-phosphatase activity
I1E95_RS05220	COG1968	undecaprenyl-diphosphatase activity
I1E95_RS05230	COG1555	photosystem II stabilization
I1E95_RS05235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I1E95_RS05240	COG4243	Vitamin k epoxide reductase
I1E95_RS05245	COG0434	BtpA family
I1E95_RS05250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1E95_RS05265	COG1032	radical SAM domain protein
I1E95_RS05295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I1E95_RS05320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I1E95_RS05325	COG1472	Belongs to the glycosyl hydrolase 3 family
I1E95_RS05330	COG0463	Glycosyl transferase, family 2
I1E95_RS05330	COG0457	Tetratricopeptide repeat
I1E95_RS05335	COG1587	Uroporphyrinogen-III synthase
I1E95_RS05350	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I1E95_RS05355	COG0316	Belongs to the HesB IscA family
I1E95_RS05375	COG1090	epimerase
I1E95_RS05385	COG0484	heat shock protein binding
I1E95_RS05390	COG3659	wide pore channel activity
I1E95_RS05395	COG3659	wide pore channel activity
I1E95_RS05425	COG1122	ATPase activity
I1E95_RS05435	COG0745	RESPONSE REGULATOR receiver
I1E95_RS05440	COG0470	DNA polymerase III
I1E95_RS05445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I1E95_RS05450	COG2217	Heavy metal translocating P-type atpase
I1E95_RS05455	COG0457	Tetratricopeptide repeat
I1E95_RS05460	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I1E95_RS05465	COG0745	RESPONSE REGULATOR receiver
I1E95_RS05470	COG0416	fatty acid biosynthetic process
I1E95_RS05475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I1E95_RS05480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I1E95_RS05495	COG1214	PFAM Peptidase M22, glycoprotease
I1E95_RS05505	COG0617	tRNA 3'-terminal CCA addition
I1E95_RS05510	COG0724	RNA recognition motif
I1E95_RS05520	COG1562	ergosterol biosynthetic process
I1E95_RS05525	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I1E95_RS05525	COG0493	'glutamate synthase
I1E95_RS05540	COG0583	DNA-binding transcription factor activity
I1E95_RS05550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I1E95_RS05555	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_RS05570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I1E95_RS05590	COG2954	triphosphatase activity
I1E95_RS05595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I1E95_RS05605	COG0839	Belongs to the complex I subunit 6 family
I1E95_RS05610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_RS05615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I1E95_RS05620	COG0372	Belongs to the citrate synthase family
I1E95_RS05625	COG2062	phosphohistidine phosphatase, SixA
I1E95_RS05635	COG1054	Belongs to the UPF0176 family
I1E95_RS05640	COG1420	regulation of RNA biosynthetic process
I1E95_RS05650	COG0133	tryptophan synthase activity
I1E95_RS05660	COG0023	Translation Initiation Factor
I1E95_RS05665	COG0529	Catalyzes the synthesis of activated sulfate
I1E95_RS05670	COG0628	permease
I1E95_RS05680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I1E95_RS05685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I1E95_RS05690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1E95_RS05695	COG0067	glutamate synthase
I1E95_RS05695	COG0069	glutamate synthase activity
I1E95_RS05695	COG0070	glutamate synthase
I1E95_RS05715	COG0049	tRNA binding
I1E95_RS05720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I1E95_RS05725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I1E95_RS05730	COG0051	transcription antitermination factor activity, RNA binding
I1E95_RS05740	COG2226	methyltransferase
I1E95_RS05745	COG0077	Prephenate dehydratase
I1E95_RS05745	COG1605	Chorismate mutase
I1E95_RS05755	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I1E95_RS05760	COG1530	ribonuclease E activity
I1E95_RS05770	COG0436	Aminotransferase
I1E95_RS05775	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I1E95_RS05790	COG3328	transposase activity
I1E95_RS05800	COG3328	transposase activity
I1E95_RS05820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1E95_RS05825	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I1E95_RS05840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I1E95_RS05850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_RS05855	COG0529	Catalyzes the synthesis of activated sulfate
I1E95_RS05855	COG2046	Belongs to the sulfate adenylyltransferase family
I1E95_RS05870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I1E95_RS05875	COG3536	Protein conserved in bacteria
I1E95_RS05885	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
I1E95_RS05900	COG0540	Belongs to the ATCase OTCase family
I1E95_RS05905	COG2094	Belongs to the DNA glycosylase MPG family
I1E95_RS05920	COG1402	creatininase
I1E95_RS05925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I1E95_RS05940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I1E95_RS05945	COG0640	Transcriptional regulator
I1E95_RS05950	COG0798	PFAM Bile acid sodium symporter
I1E95_RS05955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1E95_RS05960	COG5002	protein histidine kinase activity
I1E95_RS05965	COG0745	RESPONSE REGULATOR receiver
I1E95_RS05970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_RS06015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I1E95_RS06050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I1E95_RS06075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1E95_RS06090	COG0717	Belongs to the dCTP deaminase family
I1E95_RS06100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_RS06105	COG4372	Transposase
I1E95_RS06120	COG0193	aminoacyl-tRNA hydrolase activity
I1E95_RS06125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I1E95_RS06155	COG0066	3-isopropylmalate dehydratase activity
I1E95_RS06160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I1E95_RS06170	COG1058	Belongs to the CinA family
I1E95_RS06170	COG1546	Belongs to the CinA family
I1E95_RS06175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I1E95_RS06180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I1E95_RS06205	COG0728	peptidoglycan biosynthetic process
I1E95_RS06210	COG1489	DNA binding
I1E95_RS06215	COG0004	ammonium transporteR
I1E95_RS06220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I1E95_RS06235	COG0138	bifunctional purine biosynthesis protein purh
I1E95_RS06250	COG2205	protein histidine kinase activity
I1E95_RS06255	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I1E95_RS06260	COG0343	queuine tRNA-ribosyltransferase activity
I1E95_RS06280	COG0673	inositol 2-dehydrogenase activity
I1E95_RS06285	COG1253	flavin adenine dinucleotide binding
I1E95_RS06290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I1E95_RS06295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_RS06300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1E95_RS06305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1E95_RS06310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I1E95_RS06330	COG3328	transposase activity
I1E95_RS06350	COG1484	DNA-dependent DNA replication
I1E95_RS06355	COG3328	transposase activity
I1E95_RS06375	COG3328	transposase activity
I1E95_RS06380	COG0463	Glycosyl transferase, family 2
I1E95_RS06390	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I1E95_RS06405	COG1473	amidohydrolase
I1E95_RS06430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I1E95_RS06475	COG2826	transposase and inactivated derivatives, IS30 family
I1E95_RS06480	COG2801	Transposase and inactivated derivatives
I1E95_RS06485	COG3328	transposase activity
I1E95_RS06510	COG1132	(ABC) transporter
I1E95_RS06540	COG0617	tRNA 3'-terminal CCA addition
I1E95_RS06545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I1E95_RS06550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I1E95_RS06560	COG5398	heme oxygenase
I1E95_RS06570	COG0538	isocitrate dehydrogenase activity
I1E95_RS06575	COG0247	lactate metabolic process
I1E95_RS06585	COG0277	FAD linked oxidase domain protein
I1E95_RS06640	COG0668	transmembrane transport
I1E95_RS06690	COG0071	Belongs to the small heat shock protein (HSP20) family
I1E95_RS06700	COG3119	arylsulfatase activity
I1E95_RS06705	COG1116	anion transmembrane transporter activity
I1E95_RS06710	COG1116	anion transmembrane transporter activity
I1E95_RS06710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1E95_RS06715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1E95_RS06720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1E95_RS06730	COG0347	Belongs to the P(II) protein family
I1E95_RS06740	COG0426	domain, Protein
I1E95_RS06740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1E95_RS06745	COG0426	domain, Protein
I1E95_RS06745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1E95_RS06755	COG1902	pentaerythritol trinitrate reductase activity
I1E95_RS06760	COG1741	Belongs to the pirin family
I1E95_RS06785	COG0509	glycine decarboxylation via glycine cleavage system
I1E95_RS06790	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I1E95_RS06810	COG0359	binds to the 23S rRNA
I1E95_RS06815	COG1372	Participates in initiation and elongation during chromosome replication
I1E95_RS06815	COG1372	Participates in initiation and elongation during chromosome replication
I1E95_RS06815	COG0305	Participates in initiation and elongation during chromosome replication
I1E95_RS06815	COG0305	Participates in initiation and elongation during chromosome replication
I1E95_RS06840	COG0445	tRNA wobble uridine modification
I1E95_RS06880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I1E95_RS06890	COG0398	Pfam SNARE associated Golgi protein
I1E95_RS06915	COG1970	mechanosensitive ion channel activity
I1E95_RS06925	COG0525	valine-tRNA ligase activity
I1E95_RS06985	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I1E95_RS07000	COG3264	Mechanosensitive ion channel
I1E95_RS07000	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I1E95_RS07005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1E95_RS07005	COG1116	anion transmembrane transporter activity
I1E95_RS07010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1E95_RS07015	COG1116	anion transmembrane transporter activity
I1E95_RS07020	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I1E95_RS07035	COG2144	transferase activity, transferring acyl groups
I1E95_RS07060	COG2072	flavoprotein involved in K transport
I1E95_RS07070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I1E95_RS07085	COG0625	glutathione transferase activity
I1E95_RS07110	COG2217	Heavy metal translocating P-type atpase
I1E95_RS07125	COG2226	methyltransferase
I1E95_RS07140	COG0303	'Molybdopterin
I1E95_RS07145	COG0315	cyclic pyranopterin monophosphate synthase activity
I1E95_RS07155	COG1595	DNA-templated transcription, initiation
I1E95_RS07170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1E95_RS07185	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I1E95_RS07190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_RS07195	COG0170	dolichyl monophosphate biosynthetic process
I1E95_RS07205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I1E95_RS07210	COG1049	propionate catabolic process, 2-methylcitrate cycle
I1E95_RS07235	COG0788	formyltetrahydrofolate deformylase activity
I1E95_RS07250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1E95_RS07255	COG0443	Heat shock 70 kDa protein
I1E95_RS07260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I1E95_RS07270	COG0360	Binds together with S18 to 16S ribosomal RNA
I1E95_RS07280	COG0137	argininosuccinate synthase activity
I1E95_RS07295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I1E95_RS07310	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I1E95_RS07325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I1E95_RS07330	COG0497	DNA recombination
I1E95_RS07335	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1E95_RS07345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I1E95_RS07350	COG0592	DNA-directed DNA polymerase activity
I1E95_RS07365	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I1E95_RS07370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I1E95_RS07380	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I1E95_RS07395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I1E95_RS07400	COG0552	protein localization to endoplasmic reticulum
I1E95_RS07405	COG2208	phosphoserine phosphatase activity
I1E95_RS07410	COG0165	Argininosuccinate lyase
I1E95_RS07415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I1E95_RS07420	COG2081	HI0933 family
I1E95_RS07445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I1E95_RS07450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I1E95_RS07455	COG0484	heat shock protein binding
I1E95_RS07470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I1E95_RS07475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I1E95_RS07480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I1E95_RS07485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I1E95_RS07490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I1E95_RS07495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1E95_RS07500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I1E95_RS07505	COG0511	ligase activity, forming carbon-carbon bonds
I1E95_RS07510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I1E95_RS07595	COG0402	S-adenosylhomocysteine deaminase activity
I1E95_RS07600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I1E95_RS07600	COG0784	Response regulator, receiver
I1E95_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
I1E95_RS07695	COG3328	transposase activity
I1E95_RS07875	COG1061	Type III restriction enzyme res subunit
I1E95_RS07950	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I1E95_RS07955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I1E95_RS07955	COG0519	Catalyzes the synthesis of GMP from XMP
I1E95_RS07970	COG0768	penicillin binding
I1E95_RS07975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I1E95_RS07975	COG0438	transferase activity, transferring glycosyl groups
I1E95_RS07990	COG2022	thiamine diphosphate biosynthetic process
I1E95_RS08005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I1E95_RS08010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I1E95_RS08015	COG2385	sporulation resulting in formation of a cellular spore
I1E95_RS08020	COG1215	transferase activity, transferring glycosyl groups
I1E95_RS08025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I1E95_RS08035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I1E95_RS08040	COG0740	serine-type endopeptidase activity
I1E95_RS08045	COG0544	peptidyl-prolyl cis-trans isomerase activity
I1E95_RS08050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I1E95_RS08055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1E95_RS08060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I1E95_RS08070	COG0037	tRNA processing
I1E95_RS08085	COG0556	nucleotide-excision repair
I1E95_RS08090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I1E95_RS08115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I1E95_RS08125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I1E95_RS08130	COG0438	transferase activity, transferring glycosyl groups
I1E95_RS08185	COG3328	transposase activity
I1E95_RS08220	COG3328	transposase activity
I1E95_RS08235	COG0653	protein targeting
I1E95_RS08245	COG1725	Transcriptional regulator
I1E95_RS08255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I1E95_RS08260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I1E95_RS08265	COG1372	Participates in initiation and elongation during chromosome replication
I1E95_RS08265	COG0187	DNA topoisomerase II activity
I1E95_RS08280	COG0386	Belongs to the glutathione peroxidase family
I1E95_RS08285	COG2239	Acts as a magnesium transporter
I1E95_RS08290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_RS08310	COG0802	atpase or kinase
I1E95_RS08315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I1E95_RS08320	COG0586	Pfam SNARE associated Golgi protein
I1E95_RS08325	COG0629	single-stranded DNA binding
I1E95_RS08350	COG0745	RESPONSE REGULATOR receiver
I1E95_RS08355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I1E95_RS08380	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I1E95_RS08385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I1E95_RS08395	COG0515	serine threonine protein kinase
I1E95_RS08395	COG3266	domain, Protein
I1E95_RS08400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I1E95_RS08405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1E95_RS08435	COG0411	ABC transporter
I1E95_RS08455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I1E95_RS08460	COG0830	nickel cation binding
I1E95_RS08465	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I1E95_RS08470	COG0829	nickel cation binding
I1E95_RS08475	COG2211	Major facilitator Superfamily
I1E95_RS08485	COG0832	Belongs to the urease beta subunit family
I1E95_RS08495	COG2308	Evidence 4 Homologs of previously reported genes of
I1E95_RS08510	COG0058	SHG alpha-glucan phosphorylase activity
I1E95_RS08520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I1E95_RS08525	COG0709	Synthesizes selenophosphate from selenide and ATP
I1E95_RS08530	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I1E95_RS08530	COG0662	Cupin 2, conserved barrel domain protein
I1E95_RS08535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I1E95_RS08545	COG0571	ribonuclease III activity
I1E95_RS08570	COG0058	SHG alpha-glucan phosphorylase activity
I1E95_RS08575	COG0475	glutathione-regulated potassium exporter activity
I1E95_RS08595	COG0010	Belongs to the arginase family
I1E95_RS08600	COG0375	protein maturation
I1E95_RS08625	COG1116	anion transmembrane transporter activity
I1E95_RS08660	COG1653	transport
I1E95_RS08665	COG1175	transmembrane transport
I1E95_RS08670	COG0395	ABC-type sugar transport system, permease component
I1E95_RS08675	COG3842	ATPase activity
I1E95_RS08710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1E95_RS08740	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1E95_RS08750	COG1704	LemA family
I1E95_RS08805	COG3956	TIGRFAM MazG family protein
I1E95_RS08825	COG0010	Belongs to the arginase family
I1E95_RS08845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I1E95_RS08850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_RS08855	COG0783	Belongs to the Dps family
I1E95_RS08860	COG0504	CTP synthase activity
I1E95_RS08875	COG0602	queuosine metabolic process
I1E95_RS08880	COG0124	histidyl-tRNA synthetase
I1E95_RS08885	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I1E95_RS08920	COG4447	cellulose binding
I1E95_RS08925	COG1773	rubredoxin
I1E95_RS08930	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_RS08935	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_RS08945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I1E95_RS08950	COG3842	ATPase activity
I1E95_RS08960	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I1E95_RS08960	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I1E95_RS08990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1E95_RS09005	COG3328	transposase activity
I1E95_RS09020	COG0644	oxidoreductase
I1E95_RS09025	COG2890	protein-(glutamine-N5) methyltransferase activity
I1E95_RS09040	COG0598	Magnesium transport protein CorA
I1E95_RS09055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1E95_RS09065	COG1032	radical SAM domain protein
I1E95_RS09100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1E95_RS09130	COG2345	Transcriptional regulator
I1E95_RS09135	COG0154	amidase activity
I1E95_RS09175	COG0556	nucleotide-excision repair
I1E95_RS09185	COG3328	transposase activity
I1E95_RS09225	COG2361	Protein of unknown function DUF86
I1E95_RS09290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_RS09295	COG2124	cytochrome p450
I1E95_RS09305	COG4413	Urea transporter
I1E95_RS09355	COG0071	Belongs to the small heat shock protein (HSP20) family
I1E95_RS09360	COG1231	oxidoreductase activity
I1E95_RS09370	COG2226	methyltransferase
I1E95_RS09385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I1E95_RS09390	COG0494	nUDIX hydrolase
I1E95_RS09395	COG0415	Belongs to the DNA photolyase family
I1E95_RS09425	COG0415	Belongs to the DNA photolyase family
I1E95_RS09430	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I1E95_RS09440	COG0131	Imidazoleglycerol-phosphate dehydratase
I1E95_RS09445	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I1E95_RS09475	COG3264	Mechanosensitive ion channel
I1E95_RS09475	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I1E95_RS09505	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I1E95_RS09510	COG3119	arylsulfatase activity
I1E95_RS09520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I1E95_RS09525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I1E95_RS09535	COG0354	folic acid binding
I1E95_RS09540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I1E95_RS09595	COG3328	transposase activity
I1E95_RS09625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I1E95_RS09640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1E95_RS09645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I1E95_RS09655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1E95_RS09660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1E95_RS09665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1E95_RS09665	COG1116	anion transmembrane transporter activity
I1E95_RS09670	COG1116	anion transmembrane transporter activity
I1E95_RS09675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_RS09680	COG0243	molybdopterin cofactor binding
I1E95_RS09695	COG0746	molybdenum cofactor guanylyltransferase activity
I1E95_RS09700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I1E95_RS09745	COG2814	Major facilitator Superfamily
I1E95_RS09760	COG0438	transferase activity, transferring glycosyl groups
I1E95_RS09765	COG0561	phosphatase activity
I1E95_RS09765	COG3100	YcgL domain-containing protein
I1E95_RS09780	COG0521	Mo-molybdopterin cofactor biosynthetic process
I1E95_RS09790	COG1597	lipid kinase activity
I1E95_RS09790	COG1803	Methylglyoxal synthase
I1E95_RS09795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I1E95_RS09805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I1E95_RS09810	COG2066	Belongs to the glutaminase family
I1E95_RS09810	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I1E95_RS09825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_RS09845	COG1166	arginine decarboxylase activity
I1E95_RS09915	COG0105	UTP biosynthetic process
I1E95_RS09925	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I1E95_RS09940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1E95_RS09940	COG2022	thiamine diphosphate biosynthetic process
I1E95_RS09960	COG0237	dephospho-CoA kinase activity
I1E95_RS09965	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I1E95_RS09980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1E95_RS09985	COG0148	phosphopyruvate hydratase activity
I1E95_RS09990	COG0346	lactoylglutathione lyase activity
I1E95_RS09995	COG0542	response to heat
I1E95_RS10000	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I1E95_RS10005	COG0250	Participates in transcription elongation, termination and antitermination
I1E95_RS10010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I1E95_RS10015	COG0081	regulation of translation
I1E95_RS10020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I1E95_RS10025	COG0222	ribosome binding
I1E95_RS10040	COG0167	dihydroorotate dehydrogenase activity
I1E95_RS10075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I1E95_RS10085	COG2084	Dehydrogenase
I1E95_RS10100	COG0589	response to stress
I1E95_RS10105	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I1E95_RS10110	COG0564	pseudouridine synthase activity
I1E95_RS10115	COG0038	chloride channel
I1E95_RS10120	COG4172	Belongs to the ABC transporter superfamily
I1E95_RS10125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I1E95_RS10160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I1E95_RS10165	COG0157	Belongs to the NadC ModD family
I1E95_RS10185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I1E95_RS10210	COG0641	radical SAM
I1E95_RS10215	COG0018	arginyl-trna synthetase
I1E95_RS10220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1E95_RS10235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I1E95_RS10240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I1E95_RS10255	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I1E95_RS10260	COG0189	ligase activity
I1E95_RS10270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1E95_RS10280	COG1575	Belongs to the MenA family. Type 1 subfamily
I1E95_RS10310	COG0824	Thioesterase
I1E95_RS10315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I1E95_RS10330	COG0275	rRNA processing
I1E95_RS10340	COG1104	cysteine desulfurase activity
I1E95_RS10350	COG0745	RESPONSE REGULATOR receiver
I1E95_RS10355	COG0564	pseudouridine synthase activity
I1E95_RS10365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I1E95_RS10385	COG2885	chlorophyll binding
I1E95_RS10390	COG2885	chlorophyll binding
I1E95_RS10415	COG0463	Glycosyl transferase, family 2
I1E95_RS10420	COG0791	NLP P60 protein
I1E95_RS10435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I1E95_RS10445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I1E95_RS10450	COG0254	rRNA binding
I1E95_RS10455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I1E95_RS10465	COG0101	tRNA pseudouridine synthase activity
I1E95_RS10470	COG0203	ribosomal protein L17
I1E95_RS10475	COG0202	RNA polymerase activity
I1E95_RS10485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I1E95_RS10490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I1E95_RS10495	COG0563	adenylate kinase activity
I1E95_RS10500	COG0201	protein transport
I1E95_RS10505	COG0200	Binds to the 23S rRNA
I1E95_RS10510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I1E95_RS10515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I1E95_RS10520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I1E95_RS10525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I1E95_RS10530	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I1E95_RS10535	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I1E95_RS10540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I1E95_RS10545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I1E95_RS10550	COG0255	Belongs to the universal ribosomal protein uL29 family
I1E95_RS10555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I1E95_RS10560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I1E95_RS10565	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I1E95_RS10570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I1E95_RS10575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I1E95_RS10580	COG0089	rRNA binding
I1E95_RS10585	COG0088	Forms part of the polypeptide exit tunnel
I1E95_RS10590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I1E95_RS10605	COG3854	ATPases associated with a variety of cellular activities
I1E95_RS10650	COG3001	Fructosamine kinase
I1E95_RS10670	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I1E95_RS10675	COG1606	tRNA processing
I1E95_RS10680	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I1E95_RS10685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I1E95_RS10695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I1E95_RS10700	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I1E95_RS10705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1E95_RS10720	COG0772	Belongs to the SEDS family
I1E95_RS10725	COG0489	protein tyrosine kinase activity
I1E95_RS10730	COG0408	coproporphyrinogen oxidase activity
I1E95_RS10785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I1E95_RS10790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I1E95_RS10790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I1E95_RS10795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I1E95_RS10840	COG5398	heme oxygenase
I1E95_RS10910	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_RS10925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I1E95_RS10940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I1E95_RS10980	COG1070	Carbohydrate kinase
I1E95_RS10995	COG0539	negative regulation of cytoplasmic translation
I1E95_RS11040	COG2890	protein-(glutamine-N5) methyltransferase activity
I1E95_RS11045	COG0009	L-threonylcarbamoyladenylate synthase
I1E95_RS11085	COG0651	ATP synthesis coupled electron transport
I1E95_RS11090	COG1006	Multisubunit Na H antiporter MnhC subunit
I1E95_RS11100	COG3328	transposase activity
I1E95_RS11115	COG4566	intracellular signal transduction
I1E95_RS11120	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I1E95_RS11125	COG2894	cell division
I1E95_RS11145	COG0850	regulation of cytokinetic process
I1E95_RS11150	COG1078	dGTPase activity
I1E95_RS11155	COG0793	Belongs to the peptidase S41A family
I1E95_RS11160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I1E95_RS11165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I1E95_RS11200	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I1E95_RS11205	COG0235	Class ii aldolase
I1E95_RS11210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I1E95_RS11225	COG0514	ATP-dependent DNA helicase (RecQ)
I1E95_RS11230	COG1705	Flagellar rod assembly protein muramidase FlgJ
I1E95_RS11230	COG1388	LysM domain
I1E95_RS11235	COG1012	belongs to the aldehyde dehydrogenase family
I1E95_RS11250	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I1E95_RS11275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I1E95_RS11285	COG1160	GTP binding
I1E95_RS11290	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I1E95_RS11300	COG3328	transposase activity
I1E95_RS11305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I1E95_RS11310	COG1799	cell septum assembly
I1E95_RS11315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I1E95_RS11320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I1E95_RS11335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I1E95_RS11340	COG2211	Major facilitator Superfamily
I1E95_RS11350	COG1523	belongs to the glycosyl hydrolase 13 family
I1E95_RS11360	COG0776	regulation of translation
I1E95_RS11390	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I1E95_RS11390	COG0674	pyruvate-flavodoxin oxidoreductase activity
I1E95_RS11390	COG1013	pyruvate-flavodoxin oxidoreductase activity
I1E95_RS11390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I1E95_RS11395	COG0298	carbon dioxide binding
I1E95_RS11400	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I1E95_RS11405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I1E95_RS11410	COG0375	protein maturation
I1E95_RS11420	COG3259	Nickel-dependent hydrogenase
I1E95_RS11430	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_RS11475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I1E95_RS11480	COG1218	3'(2'),5'-bisphosphate nucleotidase
I1E95_RS11490	COG1185	polyribonucleotide nucleotidyltransferase activity
I1E95_RS11500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I1E95_RS11505	COG0750	zinc metalloprotease
I1E95_RS11515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I1E95_RS11520	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I1E95_RS11525	COG0481	GTPase activity
I1E95_RS11570	COG4795	General secretion pathway protein
I1E95_RS11595	COG3328	transposase activity
I1E95_RS11610	COG3328	transposase activity
I1E95_RS11615	COG4968	Prepilin-type N-terminal cleavage methylation domain
I1E95_RS11630	COG0745	RESPONSE REGULATOR receiver
I1E95_RS11635	COG3328	transposase activity
I1E95_RS11690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I1E95_RS11695	COG0598	Magnesium transport protein CorA
I1E95_RS11700	COG1028	Short-chain dehydrogenase reductase Sdr
I1E95_RS11700	COG3347	Dehydrogenase
I1E95_RS11715	COG0242	peptide deformylase activity
I1E95_RS11730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I1E95_RS11735	COG0606	chelatase, subunit chli
I1E95_RS11740	COG0537	adenosine 5'-monophosphoramidase activity
I1E95_RS11745	COG4178	(ABC) transporter
I1E95_RS11765	COG0515	serine threonine protein kinase
I1E95_RS11780	COG0439	Biotin carboxylase
I1E95_RS11795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1E95_RS11805	COG1196	nuclear chromosome segregation
I1E95_RS11825	COG0116	Belongs to the methyltransferase superfamily
I1E95_RS11840	COG3328	transposase activity
I1E95_RS11935	COG4243	Vitamin k epoxide reductase
I1E95_RS11940	COG0484	heat shock protein binding
I1E95_RS11945	COG0113	porphobilinogen synthase activity
I1E95_RS11955	COG1193	negative regulation of DNA recombination
I1E95_RS11960	COG3842	ATPase activity
I1E95_RS11965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I1E95_RS11975	COG0488	(ABC) transporter
I1E95_RS11985	COG0435	Glutathione S-transferase
I1E95_RS11990	COG2988	succinylglutamate desuccinylase activity
I1E95_RS12035	COG3266	domain, Protein
I1E95_RS12035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I1E95_RS12045	COG0195	Participates in both transcription termination and antitermination
I1E95_RS12050	COG0779	Required for maturation of 30S ribosomal subunits
I1E95_RS12060	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I1E95_RS12065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1E95_RS12070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I1E95_RS12075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I1E95_RS12085	COG0084	hydrolase, TatD family'
I1E95_RS12095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I1E95_RS12100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I1E95_RS12105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_RS12110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I1E95_RS12115	COG2223	nitrite transmembrane transporter activity
I1E95_RS12145	COG0357	Ribosomal RNA small subunit methyltransferase G
I1E95_RS12150	COG0484	heat shock protein binding
I1E95_RS12160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I1E95_RS12170	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I1E95_RS12175	COG2226	methyltransferase
I1E95_RS12185	COG0156	8-amino-7-oxononanoate synthase activity
I1E95_RS12190	COG4581	dead DEAH box helicase
I1E95_RS12195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I1E95_RS12205	COG0347	Belongs to the P(II) protein family
I1E95_RS12215	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I1E95_RS12230	COG0772	Belongs to the SEDS family
I1E95_RS12250	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I1E95_RS12255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1E95_RS12275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I1E95_RS12280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I1E95_RS12290	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I1E95_RS12295	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I1E95_RS12305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1E95_RS12315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1E95_RS12320	COG0686	Belongs to the AlaDH PNT family
I1E95_RS12325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1E95_RS12325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I1E95_RS12330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I1E95_RS12335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I1E95_RS12340	COG1253	flavin adenine dinucleotide binding
I1E95_RS12345	COG0006	proline dipeptidase activity
I1E95_RS12390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1E95_RS12405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I1E95_RS12410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I1E95_RS12415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I1E95_RS12420	COG0459	protein refolding
I1E95_RS12435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I1E95_RS12440	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I1E95_RS12455	COG0443	Heat shock 70 kDa protein
I1E95_RS12490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I1E95_RS12510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I1E95_RS12515	COG2264	protein methyltransferase activity
I1E95_RS12530	COG2010	Cytochrome c
I1E95_RS12535	COG1234	tRNA 3'-trailer cleavage
I1E95_RS12540	COG2385	sporulation resulting in formation of a cellular spore
I1E95_RS12545	COG0363	glucosamine-6-phosphate deaminase activity
I1E95_RS12550	COG0217	transcriptional regulatory protein
I1E95_RS12555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I1E95_RS12560	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I1E95_RS12565	COG0500	methyltransferase
I1E95_RS12570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I1E95_RS12575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I1E95_RS12585	COG4251	negative regulation of phosphorylation
I1E95_RS12590	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I1E95_RS12595	COG5002	protein histidine kinase activity
I1E95_RS12600	COG0151	Belongs to the GarS family
I1E95_RS12620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I1E95_RS12625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I1E95_RS12630	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I1E95_RS12635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I1E95_RS12640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1E95_RS12655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I1E95_RS12680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I1E95_RS12685	COG0284	orotidine-5'-phosphate decarboxylase activity
I1E95_RS12690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I1E95_RS12700	COG0438	transferase activity, transferring glycosyl groups
I1E95_RS12710	COG1381	Involved in DNA repair and RecF pathway recombination
I1E95_RS12715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I1E95_RS12720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I1E95_RS12725	COG0321	lipoyl(octanoyl) transferase activity
I1E95_RS12730	COG1022	Amp-dependent synthetase and ligase
I1E95_RS12740	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1E95_RS12745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I1E95_RS12750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I1E95_RS12765	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I1E95_RS12775	COG0724	RNA recognition motif
I1E95_RS12785	COG1799	cell septum assembly
I1E95_RS12815	COG0366	Alpha amylase catalytic
I1E95_RS12830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I1E95_RS12835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I1E95_RS12840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_RS12885	COG0628	permease
I1E95_RS12915	COG0668	transmembrane transport
I1E95_RS12920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1E95_RS12920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1E95_RS12950	COG0745	RESPONSE REGULATOR receiver
I1E95_RS12955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I1E95_RS12960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I1E95_RS12965	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I1E95_RS12975	COG0196	riboflavin kinase activity
I1E95_RS12980	COG0352	thiamine-phosphate diphosphorylase activity
I1E95_RS12995	COG1691	(AIR) carboxylase
I1E95_RS13005	COG0336	Belongs to the RNA methyltransferase TrmD family
I1E95_RS13015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I1E95_RS13025	COG0670	Belongs to the BI1 family
I1E95_RS13030	COG1702	phosphate starvation-inducible protein PhoH
I1E95_RS13040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I1E95_RS13050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I1E95_RS13055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_RS13060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I1E95_RS13060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I1E95_RS13065	COG0482	sulfurtransferase activity
I1E95_RS13075	COG1492	cobalamin metabolic process
I1E95_RS13085	COG0424	maF-like protein
I1E95_RS13110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1E95_RS13115	COG0440	acetolactate synthase activity
I1E95_RS13120	COG2267	carboxylic ester hydrolase activity
I1E95_RS13135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1E95_RS13150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I1E95_RS13155	COG0492	ferredoxin-NADP+ reductase activity
I1E95_RS13175	COG0702	epimerase
I1E95_RS13190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I1E95_RS13200	COG0215	cysteine-tRNA ligase activity
I1E95_RS13210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1E95_RS13210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1E95_RS13225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I1E95_RS13245	COG0335	large ribosomal subunit rRNA binding
I1E95_RS13255	COG0024	Methionine aminopeptidase
I1E95_RS13260	COG3000	fatty acid hydroxylase
I1E95_RS13260	COG0300	oxidoreductase activity
I1E95_RS13270	COG0857	belongs to the CobB CobQ family
I1E95_RS13285	COG0330	HflC and HflK could
I1E95_RS13295	COG1666	GTP binding
I1E95_RS13310	COG0405	Gamma-glutamyltransferase
I1E95_RS13355	COG0129	dihydroxy-acid dehydratase activity
I1E95_RS13370	COG0363	glucosamine-6-phosphate deaminase activity
I1E95_RS13375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I1E95_RS13380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I1E95_RS13385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I1E95_RS13390	COG1494	fructose-1,6-bisphosphatase
I1E95_RS13395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I1E95_RS13400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I1E95_RS13425	COG1217	gtp-binding protein TYPA
I1E95_RS13435	COG0644	oxidoreductase
I1E95_RS13440	COG0751	glycine-tRNA ligase activity
I1E95_RS13445	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1E95_RS13455	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I1E95_RS13460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I1E95_RS13470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I1E95_RS13475	COG0052	Belongs to the universal ribosomal protein uS2 family
I1E95_RS13480	COG1216	Glycosyl transferase, family 2
I1E95_RS13510	COG0612	Peptidase, M16
I1E95_RS13530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I1E95_RS13535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1E95_RS13555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I1E95_RS13565	COG0174	glutamine synthetase
I1E95_RS13570	COG2226	methyltransferase
I1E95_RS13595	COG0515	serine threonine protein kinase
I1E95_RS13600	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I1E95_RS13610	COG0628	permease
I1E95_RS13625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1E95_RS13630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1E95_RS13635	COG0022	dehydrogenase e1 component
I1E95_RS13645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I1E95_RS13650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I1E95_RS13675	COG4555	ABC transporter
I1E95_RS13725	COG3128	pkhd-type hydroxylase
I1E95_RS13740	COG0514	ATP-dependent DNA helicase (RecQ)
I1E95_RS13750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I1E95_RS13770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I1E95_RS13785	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I1E95_RS13800	COG0740	serine-type endopeptidase activity
I1E95_RS13810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_RS13820	COG1136	(ABC) transporter
I1E95_RS13820	COG0577	efflux transmembrane transporter activity
I1E95_RS13825	COG0469	pyruvate kinase activity
I1E95_RS13850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I1E95_RS13855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I1E95_RS13885	COG0668	transmembrane transport
I1E95_RS13890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1E95_RS13895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I1E95_RS13920	COG0483	inositol monophosphate 1-phosphatase activity
I1E95_RS13925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1E95_RS13935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I1E95_RS13940	COG0581	inorganic phosphate transmembrane transporter activity
I1E95_RS13945	COG0573	inorganic phosphate transmembrane transporter activity
I1E95_RS13950	COG0443	Heat shock 70 kDa protein
I1E95_RS13955	COG0484	heat shock protein binding
I1E95_RS13965	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I1E95_RS13970	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I1E95_RS13975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1E95_RS13980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1E95_RS13980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1E95_RS13985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I1E95_RS13990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I1E95_RS14015	COG0166	Belongs to the GPI family
I1E95_RS14020	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I1E95_RS14025	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I1E95_RS14030	COG0495	leucyl-tRNA aminoacylation
I1E95_RS14040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I1E95_RS14060	COG2027	D-alanyl-D-alanine carboxypeptidase
I1E95_RS14070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I1E95_RS14075	COG0426	domain, Protein
I1E95_RS14075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1E95_RS14080	COG0322	excinuclease ABC activity
I1E95_RS14085	COG1981	membrane
I1E95_RS14090	COG0613	PHP domain protein
I1E95_RS14105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I1E95_RS14110	COG1410	methionine synthase
I1E95_RS14110	COG0646	methionine synthase
I1E95_RS14135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I1E95_RS14145	COG2385	sporulation resulting in formation of a cellular spore
I1E95_RS14180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I1E95_RS14185	COG0072	phenylalanine-tRNA ligase activity
I1E95_RS14185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1E95_RS14190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I1E95_RS14195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I1E95_RS14200	COG0557	exoribonuclease II activity
I1E95_RS14210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1E95_RS14245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I1E95_RS14265	COG0450	alkyl hydroperoxide reductase
I1E95_RS14270	COG0047	phosphoribosylformylglycinamidine synthase activity
I1E95_RS14275	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I1E95_RS14295	COG1357	PFAM Pentapeptide repeats (8 copies)
I1E95_RS14300	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I1E95_RS14305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I1E95_RS14315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1E95_RS14320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I1E95_RS14330	COG0297	glycogen (starch) synthase activity
I1E95_RS14335	COG1376	ErfK ybiS ycfS ynhG family protein
I1E95_RS14375	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I1E95_RS14380	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I1E95_RS14385	COG0681	Belongs to the peptidase S26 family
I1E95_RS14400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1E95_RS14405	COG1121	(ABC) transporter
I1E95_RS14410	COG0803	Belongs to the bacterial solute-binding protein 9 family
I1E95_RS14435	COG0180	Tryptophanyl-tRNA synthetase
I1E95_RS14455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I1E95_RS14460	COG0837	glucose binding
I1E95_RS14465	COG0083	homoserine kinase activity
I1E95_RS14470	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_RS14475	COG0339	signal peptide processing
I1E95_RS14490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I1E95_RS14495	COG1940	carbohydrate kinase activity
I1E95_RS14530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I1E95_RS14535	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I1E95_RS14545	COG3794	PFAM blue (type 1) copper domain protein
I1E95_RS14550	COG2010	Cytochrome c
I1E95_RS14575	COG0542	response to heat
I1E95_RS14590	COG0438	transferase activity, transferring glycosyl groups
I1E95_RS14620	COG0463	Glycosyl transferase, family 2
I1E95_RS14625	COG3328	transposase activity
I1E95_RS14655	COG2226	methyltransferase
I1E95_RS14675	COG0463	Glycosyl transferase, family 2
I1E95_RS14700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I1E95_RS14715	COG0546	phosphoglycolate phosphatase activity
I1E95_RS14720	COG3962	Belongs to the TPP enzyme family
I1E95_RS14745	COG3328	transposase activity
I1E95_RS14775	COG2801	Transposase and inactivated derivatives
I1E95_RS15035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1E95_RS15040	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I1E95_RS15055	COG3273	potassium ion transport
I1E95_RS15055	COG0471	metal ion transport
I1E95_RS15090	COG3328	transposase activity
I1E95_RS15095	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I1E95_RS15110	COG1088	dTDP-glucose 4,6-dehydratase activity
I1E95_RS15145	COG0708	Exodeoxyribonuclease III
I1E95_RS15165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1E95_RS15170	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I1E95_RS15180	COG0735	belongs to the Fur family
I1E95_RS15200	COG1840	ABC-type Fe3 transport system, periplasmic component
I1E95_RS15210	COG0432	Pfam Uncharacterised protein family UPF0047
I1E95_RS15235	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I1E95_RS15240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I1E95_RS15255	COG0181	hydroxymethylbilane synthase activity
I1E95_RS15270	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I1E95_RS15275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1E95_RS15280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I1E95_RS15290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I1E95_RS15315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1E95_RS15330	COG0442	prolyl-tRNA aminoacylation
I1E95_RS15340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I1E95_RS15355	COG1393	Belongs to the ArsC family
I1E95_RS15375	COG0588	phosphoglycerate mutase activity
I1E95_RS15390	COG0768	penicillin binding
I1E95_RS15395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I1E95_RS15405	COG0644	oxidoreductase
I1E95_RS15410	COG0233	cytoplasmic translational termination
I1E95_RS15415	COG0528	UMP kinase activity
I1E95_RS15430	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1E95_RS15440	COG0028	Belongs to the TPP enzyme family
I1E95_RS15465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I1E95_RS15465	COG0574	Belongs to the PEP-utilizing enzyme family
I1E95_RS15470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1E95_RS15475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I1E95_RS15485	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1E95_RS15495	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I1E95_RS15505	COG0347	Belongs to the P(II) protein family
I1E95_RS15515	COG1126	abc transporter atp-binding protein
I1E95_RS15520	COG0765	amino acid transport
I1E95_RS15525	COG4597	amino acid ABC transporter
I1E95_RS15530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1E95_RS15535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I1E95_RS15540	COG0418	dihydroorotase activity
I1E95_RS15550	COG0284	orotidine-5'-phosphate decarboxylase activity
I1E95_RS15550	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I1E95_RS15560	COG1053	succinate dehydrogenase
I1E95_RS15570	COG2199	diguanylate cyclase activity
I1E95_RS15580	COG2154	pterin-4-alpha-carbinolamine dehydratase
I1E95_RS15595	COG1752	Esterase of the alpha-beta hydrolase superfamily
I1E95_RS15620	COG3328	transposase activity
I1E95_RS15650	COG3328	transposase activity
I1E95_RS15660	COG0412	Dienelactone hydrolase
I1E95_RS15665	COG3328	transposase activity
I1E95_RS15670	COG0412	Dienelactone hydrolase
I1E95_RS15690	COG3328	transposase activity
I1E95_RS15720	COG3328	transposase activity
I1E95_RS15750	COG3328	transposase activity
I1E95_RS15815	COG3328	transposase activity
I1E95_RS15820	COG3328	transposase activity
I1E95_RS15825	COG3328	transposase activity
I1E95_RS15840	COG3328	transposase activity
I1E95_RS15845	COG3328	transposase activity
I1E95_RS15975	COG1111	helicase
I1E95_RS15975	COG1205	dead DEAH box helicase
I1E95_RS16020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1E95_RS16045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1E95_RS16095	COG0535	radical SAM domain protein
I1E95_RS16110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I1E95_RS16155	COG1061	Type III restriction enzyme res subunit
I1E95_RS16350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I1E95_RS16365	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I1E95_RS16440	COG0596	Alpha beta hydrolase
I1E95_RS16445	COG3263	regulation of cellular component size
I1E95_RS16465	COG3328	transposase activity
I1E95_RS16470	COG3328	transposase activity
I1E95_RS16485	COG2963	transposase activity
I1E95_RS16490	COG2801	Transposase and inactivated derivatives
I1E95_RS16535	COG0804	urea catabolic process
I1E95_RS16575	COG3328	transposase activity
I1E95_RS16595	COG2135	peptidase activity
I1E95_RS16600	COG0419	ATPase involved in DNA repair
I1E95_RS16605	COG0420	3'-5' exonuclease activity
I1E95_RS16620	COG0251	oxidation-reduction process
I1E95_RS16625	COG3842	ATPase activity
I1E95_RS16630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1E95_RS16635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I1E95_RS16640	COG1132	(ABC) transporter
I1E95_RS16650	COG0456	acetyltransferase
I1E95_RS16665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain