locus-tag	class	description
H8F27_RS00030	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F27_RS00035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F27_RS00045	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F27_RS00075	COG4451	ribulose bisphosphate carboxylase, small
H8F27_RS00080	COG1850	ribulose-bisphosphate carboxylase activity
H8F27_RS00085	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F27_RS00100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8F27_RS00105	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8F27_RS00135	COG0730	response to heat
H8F27_RS00140	COG0095	Lipoate-protein ligase
H8F27_RS00145	COG1994	Peptidase M50
H8F27_RS00145	COG0517	IMP dehydrogenase activity
H8F27_RS00150	COG0135	phosphoribosylanthranilate isomerase activity
H8F27_RS00160	COG0302	gtp cyclohydrolase
H8F27_RS00165	COG1028	Short-chain dehydrogenase reductase Sdr
H8F27_RS00175	COG5322	oxidoreductase activity
H8F27_RS00180	COG3396	Phenylacetate-CoA oxygenase
H8F27_RS00190	COG0539	negative regulation of cytoplasmic translation
H8F27_RS00210	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H8F27_RS00225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8F27_RS00225	COG0574	Belongs to the PEP-utilizing enzyme family
H8F27_RS00245	COG0028	Belongs to the TPP enzyme family
H8F27_RS00255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F27_RS00280	COG0528	UMP kinase activity
H8F27_RS00285	COG0233	cytoplasmic translational termination
H8F27_RS00300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8F27_RS00305	COG0768	penicillin binding
H8F27_RS00320	COG0588	phosphoglycerate mutase activity
H8F27_RS00365	COG0442	prolyl-tRNA aminoacylation
H8F27_RS00375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8F27_RS00380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F27_RS00390	COG2099	Precorrin-6x reductase
H8F27_RS00410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8F27_RS00420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8F27_RS00425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F27_RS00435	COG0181	hydroxymethylbilane synthase activity
H8F27_RS00455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8F27_RS00460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H8F27_RS00570	COG0004	ammonium transporteR
H8F27_RS00590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8F27_RS00600	COG5002	protein histidine kinase activity
H8F27_RS00605	COG0745	RESPONSE REGULATOR receiver
H8F27_RS00610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F27_RS00635	COG0640	Transcriptional regulator
H8F27_RS00640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F27_RS00655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F27_RS00685	COG0561	phosphatase activity
H8F27_RS00685	COG3100	YcgL domain-containing protein
H8F27_RS00690	COG0438	transferase activity, transferring glycosyl groups
H8F27_RS00700	COG0395	ABC-type sugar transport system, permease component
H8F27_RS00710	COG1653	transport
H8F27_RS00720	COG3659	wide pore channel activity
H8F27_RS00735	COG0366	Alpha amylase catalytic
H8F27_RS00740	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H8F27_RS00745	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H8F27_RS00750	COG1484	DNA-dependent DNA replication
H8F27_RS00760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8F27_RS00780	COG2207	Transcriptional regulator
H8F27_RS00780	COG3708	Transcriptional regulator
H8F27_RS00785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H8F27_RS00795	COG0418	dihydroorotase activity
H8F27_RS00800	COG0284	orotidine-5'-phosphate decarboxylase activity
H8F27_RS00800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8F27_RS00805	COG3263	regulation of cellular component size
H8F27_RS00820	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H8F27_RS00825	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F27_RS00830	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F27_RS00845	COG0724	RNA recognition motif
H8F27_RS00870	COG1799	cell septum assembly
H8F27_RS00900	COG0475	glutathione-regulated potassium exporter activity
H8F27_RS00910	COG0659	secondary active sulfate transmembrane transporter activity
H8F27_RS00920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F27_RS00925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8F27_RS00935	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8F27_RS00945	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F27_RS01020	COG1215	transferase activity, transferring glycosyl groups
H8F27_RS01030	COG2176	DNA-directed DNA polymerase activity
H8F27_RS01035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F27_RS01045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8F27_RS01050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8F27_RS01055	COG0142	geranyltranstransferase activity
H8F27_RS01060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H8F27_RS01075	COG2045	Belongs to the ComB family
H8F27_RS01080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H8F27_RS01085	COG1959	2 iron, 2 sulfur cluster binding
H8F27_RS01215	COG4584	PFAM Integrase catalytic
H8F27_RS01245	COG0277	FAD linked oxidase domain protein
H8F27_RS01260	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F27_RS01280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8F27_RS01285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F27_RS01295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8F27_RS01305	COG0297	glycogen (starch) synthase activity
H8F27_RS01310	COG1376	ErfK ybiS ycfS ynhG family protein
H8F27_RS01315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H8F27_RS01320	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H8F27_RS01325	COG0681	Belongs to the peptidase S26 family
H8F27_RS01340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F27_RS01345	COG1121	(ABC) transporter
H8F27_RS01375	COG0180	Tryptophanyl-tRNA synthetase
H8F27_RS01390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8F27_RS01395	COG0837	glucose binding
H8F27_RS01400	COG0083	homoserine kinase activity
H8F27_RS01405	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F27_RS01410	COG0339	signal peptide processing
H8F27_RS01430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8F27_RS01435	COG1940	carbohydrate kinase activity
H8F27_RS01470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8F27_RS01475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8F27_RS01485	COG2010	Cytochrome c
H8F27_RS01500	COG0542	response to heat
H8F27_RS01515	COG0432	Pfam Uncharacterised protein family UPF0047
H8F27_RS01535	COG0415	Belongs to the DNA photolyase family
H8F27_RS01600	COG2197	response regulator
H8F27_RS01630	COG0281	malic enzyme
H8F27_RS01675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8F27_RS01690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F27_RS01700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8F27_RS01705	COG1429	ligase activity, forming nitrogen-metal bonds
H8F27_RS01725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8F27_RS01730	COG0149	triose-phosphate isomerase activity
H8F27_RS01740	COG1132	(ABC) transporter
H8F27_RS01760	COG1122	ATPase activity
H8F27_RS01775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8F27_RS01785	COG0799	negative regulation of ribosome biogenesis
H8F27_RS01835	COG0058	SHG alpha-glucan phosphorylase activity
H8F27_RS01865	COG0489	protein tyrosine kinase activity
H8F27_RS01880	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H8F27_RS01885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F27_RS01905	COG1480	7TM receptor with intracellular HD hydrolase
H8F27_RS01910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8F27_RS01925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F27_RS01940	COG1254	Belongs to the acylphosphatase family
H8F27_RS01945	COG1797	cobyrinic acid a,c-diamide synthase activity
H8F27_RS01950	COG3409	Peptidoglycan-binding domain 1 protein
H8F27_RS01950	COG3429	Glucose-6-phosphate dehydrogenase subunit
H8F27_RS01955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8F27_RS01975	COG2205	protein histidine kinase activity
H8F27_RS01990	COG0308	aminopeptidase N
H8F27_RS02000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8F27_RS02015	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
H8F27_RS02030	COG1187	pseudouridine synthase activity
H8F27_RS02035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F27_RS02060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F27_RS02065	COG1982	Orn Lys Arg decarboxylase major
H8F27_RS02070	COG2241	protein methyltransferase activity
H8F27_RS02070	COG2242	protein methyltransferase activity
H8F27_RS02075	COG0575	Belongs to the CDS family
H8F27_RS02085	COG0596	Alpha beta hydrolase
H8F27_RS02090	COG0371	Dehydrogenase
H8F27_RS02095	COG0542	response to heat
H8F27_RS02105	COG0019	diaminopimelate decarboxylase activity
H8F27_RS02110	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H8F27_RS02115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8F27_RS02120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8F27_RS02125	COG1054	Belongs to the UPF0176 family
H8F27_RS02135	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H8F27_RS02135	COG2066	Belongs to the glutaminase family
H8F27_RS02185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8F27_RS02200	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8F27_RS02200	COG0022	dehydrogenase e1 component
H8F27_RS02205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8F27_RS02210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8F27_RS02260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8F27_RS02265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8F27_RS02270	COG0569	domain protein
H8F27_RS02275	COG0586	Pfam SNARE associated Golgi protein
H8F27_RS02280	COG0471	metal ion transport
H8F27_RS02280	COG3273	potassium ion transport
H8F27_RS02285	COG1126	abc transporter atp-binding protein
H8F27_RS02290	COG0765	amino acid transport
H8F27_RS02295	COG4597	amino acid ABC transporter
H8F27_RS02300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8F27_RS02330	COG0159	tryptophan synthase activity
H8F27_RS02350	COG2010	Cytochrome c
H8F27_RS02400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F27_RS02415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F27_RS02420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8F27_RS02420	COG0140	phosphoribosyl-ATP diphosphatase activity
H8F27_RS02430	COG0789	Transcriptional regulator
H8F27_RS02440	COG3659	wide pore channel activity
H8F27_RS02460	COG0803	Belongs to the bacterial solute-binding protein 9 family
H8F27_RS02465	COG1121	(ABC) transporter
H8F27_RS02475	COG0701	Predicted permease
H8F27_RS02490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F27_RS02500	COG1121	(ABC) transporter
H8F27_RS02505	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H8F27_RS02520	COG3659	wide pore channel activity
H8F27_RS02525	COG0523	cobalamin synthesis protein
H8F27_RS02540	COG3659	wide pore channel activity
H8F27_RS02545	COG1840	ABC-type Fe3 transport system, periplasmic component
H8F27_RS02550	COG4176	ABC-type proline glycine betaine transport system permease component
H8F27_RS02585	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F27_RS02590	COG3119	arylsulfatase activity
H8F27_RS02610	COG0735	belongs to the Fur family
H8F27_RS02615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8F27_RS02630	COG2226	methyltransferase
H8F27_RS02660	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H8F27_RS02685	COG0708	Exodeoxyribonuclease III
H8F27_RS02695	COG0277	FAD linked oxidase domain protein
H8F27_RS02700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8F27_RS02715	COG0559	Belongs to the binding-protein-dependent transport system permease family
H8F27_RS02745	COG1666	GTP binding
H8F27_RS02760	COG0857	belongs to the CobB CobQ family
H8F27_RS02765	COG0300	oxidoreductase activity
H8F27_RS02765	COG3000	fatty acid hydroxylase
H8F27_RS02770	COG0024	Methionine aminopeptidase
H8F27_RS02775	COG0335	large ribosomal subunit rRNA binding
H8F27_RS02795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8F27_RS02825	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F27_RS02825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F27_RS02830	COG0215	cysteine-tRNA ligase activity
H8F27_RS02845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8F27_RS02900	COG0492	ferredoxin-NADP+ reductase activity
H8F27_RS02910	COG1187	pseudouridine synthase activity
H8F27_RS02920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F27_RS02940	COG0440	acetolactate synthase activity
H8F27_RS02945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F27_RS02985	COG1484	DNA-dependent DNA replication
H8F27_RS03030	COG0424	maF-like protein
H8F27_RS03040	COG2361	Protein of unknown function DUF86
H8F27_RS03050	COG0424	maF-like protein
H8F27_RS03060	COG1492	cobalamin metabolic process
H8F27_RS03070	COG0482	sulfurtransferase activity
H8F27_RS03075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8F27_RS03075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8F27_RS03080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F27_RS03085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8F27_RS03095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8F27_RS03100	COG0228	four-way junction DNA binding
H8F27_RS03110	COG0670	Belongs to the BI1 family
H8F27_RS03125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8F27_RS03140	COG0336	Belongs to the RNA methyltransferase TrmD family
H8F27_RS03150	COG0330	HflC and HflK could
H8F27_RS03160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8F27_RS03170	COG1691	(AIR) carboxylase
H8F27_RS03190	COG0196	riboflavin kinase activity
H8F27_RS03200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8F27_RS03205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8F27_RS03210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8F27_RS03215	COG0745	RESPONSE REGULATOR receiver
H8F27_RS03275	COG1012	belongs to the aldehyde dehydrogenase family
H8F27_RS03290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F27_RS03290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F27_RS03295	COG0668	transmembrane transport
H8F27_RS03310	COG2135	peptidase activity
H8F27_RS03315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F27_RS03330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8F27_RS03340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8F27_RS03385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8F27_RS03390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8F27_RS03395	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H8F27_RS03410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8F27_RS03430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F27_RS03440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8F27_RS03450	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8F27_RS03460	COG1022	Amp-dependent synthetase and ligase
H8F27_RS03470	COG0321	lipoyl(octanoyl) transferase activity
H8F27_RS03475	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8F27_RS03480	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H8F27_RS03485	COG1381	Involved in DNA repair and RecF pathway recombination
H8F27_RS03495	COG0438	transferase activity, transferring glycosyl groups
H8F27_RS03500	COG0284	orotidine-5'-phosphate decarboxylase activity
H8F27_RS03510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8F27_RS03520	COG2197	response regulator
H8F27_RS03530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F27_RS03620	COG1484	DNA-dependent DNA replication
H8F27_RS03630	COG3654	unkown
H8F27_RS03660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8F27_RS03680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8F27_RS03690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F27_RS03700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F27_RS03705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8F27_RS03710	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8F27_RS03720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8F27_RS03730	COG0151	Belongs to the GarS family
H8F27_RS03735	COG5002	protein histidine kinase activity
H8F27_RS03745	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8F27_RS03750	COG4251	negative regulation of phosphorylation
H8F27_RS03760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8F27_RS03765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8F27_RS03770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F27_RS03775	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8F27_RS03780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8F27_RS03785	COG0217	transcriptional regulatory protein
H8F27_RS03790	COG2267	carboxylic ester hydrolase activity
H8F27_RS03795	COG2267	carboxylic ester hydrolase activity
H8F27_RS03800	COG0363	glucosamine-6-phosphate deaminase activity
H8F27_RS03805	COG2385	sporulation resulting in formation of a cellular spore
H8F27_RS03805	COG2247	cell wall binding repeat
H8F27_RS03810	COG1234	tRNA 3'-trailer cleavage
H8F27_RS03815	COG2010	Cytochrome c
H8F27_RS03830	COG2264	protein methyltransferase activity
H8F27_RS03835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8F27_RS03855	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8F27_RS03885	COG0443	Heat shock 70 kDa protein
H8F27_RS03900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H8F27_RS03905	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H8F27_RS03930	COG0459	protein refolding
H8F27_RS03935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H8F27_RS03940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8F27_RS03945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8F27_RS03955	COG0745	RESPONSE REGULATOR receiver
H8F27_RS03965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8F27_RS03975	COG0006	proline dipeptidase activity
H8F27_RS03980	COG1253	flavin adenine dinucleotide binding
H8F27_RS03985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8F27_RS03990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8F27_RS03995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8F27_RS03995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F27_RS04000	COG0686	Belongs to the AlaDH PNT family
H8F27_RS04005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F27_RS04015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F27_RS04035	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8F27_RS04040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8F27_RS04045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8F27_RS04050	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8F27_RS04055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8F27_RS04075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F27_RS04080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F27_RS04100	COG0772	Belongs to the SEDS family
H8F27_RS04110	COG1333	cytochrome c biogenesis protein
H8F27_RS04115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8F27_RS04120	COG0347	Belongs to the P(II) protein family
H8F27_RS04135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H8F27_RS04145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8F27_RS04150	COG4581	dead DEAH box helicase
H8F27_RS04155	COG0156	8-amino-7-oxononanoate synthase activity
H8F27_RS04170	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8F27_RS04185	COG0484	heat shock protein binding
H8F27_RS04190	COG0357	Ribosomal RNA small subunit methyltransferase G
H8F27_RS04215	COG2223	nitrite transmembrane transporter activity
H8F27_RS04220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8F27_RS04225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F27_RS04230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8F27_RS04235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8F27_RS04240	COG0085	RNA polymerase activity
H8F27_RS04245	COG0084	hydrolase, TatD family'
H8F27_RS04250	COG0268	Binds directly to 16S ribosomal RNA
H8F27_RS04255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8F27_RS04260	COG0432	Pfam Uncharacterised protein family UPF0047
H8F27_RS04265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8F27_RS04270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F27_RS04275	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H8F27_RS04285	COG0779	Required for maturation of 30S ribosomal subunits
H8F27_RS04290	COG0195	Participates in both transcription termination and antitermination
H8F27_RS04300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8F27_RS04340	COG2988	succinylglutamate desuccinylase activity
H8F27_RS04355	COG0488	(ABC) transporter
H8F27_RS04365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8F27_RS04370	COG3842	ATPase activity
H8F27_RS04395	COG1193	negative regulation of DNA recombination
H8F27_RS04420	COG0113	porphobilinogen synthase activity
H8F27_RS04425	COG0484	heat shock protein binding
H8F27_RS04430	COG4243	Vitamin k epoxide reductase
H8F27_RS04440	COG4095	Psort location CytoplasmicMembrane, score
H8F27_RS04450	COG0300	oxidoreductase activity
H8F27_RS04460	COG0116	Belongs to the methyltransferase superfamily
H8F27_RS04475	COG1196	nuclear chromosome segregation
H8F27_RS04485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F27_RS04490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F27_RS04500	COG0439	Biotin carboxylase
H8F27_RS04515	COG0515	serine threonine protein kinase
H8F27_RS04535	COG4178	(ABC) transporter
H8F27_RS04540	COG0537	adenosine 5'-monophosphoramidase activity
H8F27_RS04550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H8F27_RS04565	COG0242	peptide deformylase activity
H8F27_RS04580	COG0235	Class ii aldolase
H8F27_RS04585	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8F27_RS04600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8F27_RS04605	COG0719	Fe-S assembly protein
H8F27_RS04610	COG0396	ATPase activity
H8F27_RS04615	COG0719	Fe-S assembly protein
H8F27_RS04620	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
H8F27_RS04640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F27_RS04685	COG0033	Phosphoglucomutase
H8F27_RS04720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F27_RS04750	COG3263	regulation of cellular component size
H8F27_RS04830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F27_RS04835	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8F27_RS04840	COG0175	sulfate reduction
H8F27_RS04845	COG1252	NADH dehydrogenase
H8F27_RS04855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8F27_RS04860	COG0450	alkyl hydroperoxide reductase
H8F27_RS04865	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H8F27_RS04885	COG0488	(ABC) transporter
H8F27_RS04900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F27_RS04915	COG1643	Atp-dependent helicase
H8F27_RS04925	COG1570	exodeoxyribonuclease VII activity
H8F27_RS04975	COG0483	inositol monophosphate 1-phosphatase activity
H8F27_RS04995	COG1968	undecaprenyl-diphosphatase activity
H8F27_RS05005	COG1555	photosystem II stabilization
H8F27_RS05010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H8F27_RS05015	COG4243	Vitamin k epoxide reductase
H8F27_RS05020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F27_RS05030	COG1032	radical SAM domain protein
H8F27_RS05060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8F27_RS05085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8F27_RS05090	COG1472	Belongs to the glycosyl hydrolase 3 family
H8F27_RS05105	COG0457	Tetratricopeptide repeat
H8F27_RS05105	COG0463	Glycosyl transferase, family 2
H8F27_RS05110	COG1587	Uroporphyrinogen-III synthase
H8F27_RS05120	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H8F27_RS05125	COG0316	Belongs to the HesB IscA family
H8F27_RS05145	COG1090	epimerase
H8F27_RS05165	COG0484	heat shock protein binding
H8F27_RS05170	COG3659	wide pore channel activity
H8F27_RS05185	COG1122	ATPase activity
H8F27_RS05195	COG0745	RESPONSE REGULATOR receiver
H8F27_RS05200	COG0470	DNA polymerase III
H8F27_RS05205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8F27_RS05210	COG2217	Heavy metal translocating P-type atpase
H8F27_RS05215	COG0457	Tetratricopeptide repeat
H8F27_RS05250	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H8F27_RS05255	COG0745	RESPONSE REGULATOR receiver
H8F27_RS05260	COG0416	fatty acid biosynthetic process
H8F27_RS05265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8F27_RS05270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8F27_RS05295	COG0617	tRNA 3'-terminal CCA addition
H8F27_RS05305	COG2267	carboxylic ester hydrolase activity
H8F27_RS05310	COG1562	ergosterol biosynthetic process
H8F27_RS05315	COG0493	'glutamate synthase
H8F27_RS05315	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H8F27_RS05330	COG0583	DNA-binding transcription factor activity
H8F27_RS05340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F27_RS05345	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F27_RS05360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8F27_RS05380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8F27_RS05385	COG0713	ATP synthesis coupled electron transport
H8F27_RS05390	COG0839	Belongs to the complex I subunit 6 family
H8F27_RS05400	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8F27_RS05405	COG0372	Belongs to the citrate synthase family
H8F27_RS05410	COG2062	phosphohistidine phosphatase, SixA
H8F27_RS05425	COG1420	regulation of RNA biosynthetic process
H8F27_RS05445	COG1598	PFAM Uncharacterised protein family UPF0150
H8F27_RS05455	COG0174	glutamine synthetase
H8F27_RS05460	COG0133	tryptophan synthase activity
H8F27_RS05505	COG0529	Catalyzes the synthesis of activated sulfate
H8F27_RS05510	COG0628	permease
H8F27_RS05515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H8F27_RS05535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F27_RS05540	COG1461	Dihydroxyacetone kinase
H8F27_RS05555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8F27_RS05565	COG2376	Dihydroxyacetone kinase
H8F27_RS05595	COG0564	pseudouridine synthase activity
H8F27_RS05600	COG0745	RESPONSE REGULATOR receiver
H8F27_RS05610	COG1104	cysteine desulfurase activity
H8F27_RS05620	COG1487	ribonuclease activity
H8F27_RS05635	COG0275	rRNA processing
H8F27_RS05645	COG0649	NAD binding
H8F27_RS05660	COG0824	Thioesterase
H8F27_RS05685	COG1575	Belongs to the MenA family. Type 1 subfamily
H8F27_RS05695	COG0189	ligase activity
H8F27_RS05700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8F27_RS05720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8F27_RS05725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8F27_RS05740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F27_RS05745	COG1177	transmembrane transport
H8F27_RS05750	COG1176	ABC-type spermidine putrescine transport system, permease component I
H8F27_RS05765	COG1231	oxidoreductase activity
H8F27_RS05785	COG0018	arginyl-trna synthetase
H8F27_RS05805	COG0157	Belongs to the NadC ModD family
H8F27_RS05825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8F27_RS05845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8F27_RS05850	COG4172	Belongs to the ABC transporter superfamily
H8F27_RS05860	COG0564	pseudouridine synthase activity
H8F27_RS05875	COG0589	response to stress
H8F27_RS05880	COG0126	phosphoglycerate kinase activity
H8F27_RS05920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8F27_RS05925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F27_RS05960	COG0167	dihydroorotate dehydrogenase activity
H8F27_RS05965	COG0328	RNA-DNA hybrid ribonuclease activity
H8F27_RS05975	COG0222	ribosome binding
H8F27_RS05980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8F27_RS05985	COG0765	amino acid transport
H8F27_RS05990	COG0081	regulation of translation
H8F27_RS05995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8F27_RS06000	COG0250	Participates in transcription elongation, termination and antitermination
H8F27_RS06005	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8F27_RS06010	COG0542	response to heat
H8F27_RS06015	COG0346	lactoylglutathione lyase activity
H8F27_RS06020	COG0148	phosphopyruvate hydratase activity
H8F27_RS06025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F27_RS06040	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H8F27_RS06045	COG0237	dephospho-CoA kinase activity
H8F27_RS06115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8F27_RS06125	COG2022	thiamine diphosphate biosynthetic process
H8F27_RS06125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F27_RS06215	COG1484	DNA-dependent DNA replication
H8F27_RS06240	COG3328	transposase activity
H8F27_RS06250	COG3328	transposase activity
H8F27_RS06260	COG0110	maltose O-acetyltransferase activity
H8F27_RS06270	COG1484	DNA-dependent DNA replication
H8F27_RS06285	COG0105	UTP biosynthetic process
H8F27_RS06315	COG1166	arginine decarboxylase activity
H8F27_RS06330	COG2198	Histidine kinase
H8F27_RS06330	COG0643	Histidine kinase
H8F27_RS06335	COG0840	transmembrane signaling receptor activity
H8F27_RS06340	COG0835	chemotaxis
H8F27_RS06345	COG0840	transmembrane signaling receptor activity
H8F27_RS06350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8F27_RS06355	COG2201	protein-glutamate methylesterase activity
H8F27_RS06370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F27_RS06420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8F27_RS06425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F27_RS06450	COG0071	Belongs to the small heat shock protein (HSP20) family
H8F27_RS06460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F27_RS06460	COG0426	domain, Protein
H8F27_RS06485	COG0426	domain, Protein
H8F27_RS06485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F27_RS06500	COG0577	efflux transmembrane transporter activity
H8F27_RS06500	COG1136	(ABC) transporter
H8F27_RS06505	COG1773	rubredoxin
H8F27_RS06515	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8F27_RS06515	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8F27_RS06520	COG0509	glycine decarboxylation via glycine cleavage system
H8F27_RS06525	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H8F27_RS06545	COG0359	binds to the 23S rRNA
H8F27_RS06550	COG0305	Participates in initiation and elongation during chromosome replication
H8F27_RS06550	COG1372	Participates in initiation and elongation during chromosome replication
H8F27_RS06550	COG0305	Participates in initiation and elongation during chromosome replication
H8F27_RS06550	COG1372	Participates in initiation and elongation during chromosome replication
H8F27_RS06565	COG0445	tRNA wobble uridine modification
H8F27_RS06610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F27_RS06620	COG0398	Pfam SNARE associated Golgi protein
H8F27_RS06630	COG1028	Short-chain dehydrogenase reductase Sdr
H8F27_RS06635	COG1028	Short-chain dehydrogenase reductase Sdr
H8F27_RS06640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8F27_RS06650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8F27_RS06655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8F27_RS06690	COG0525	valine-tRNA ligase activity
H8F27_RS06695	COG2113	Glycine betaine
H8F27_RS06700	COG4176	ABC-type proline glycine betaine transport system permease component
H8F27_RS06705	COG4175	Glycine betaine
H8F27_RS06710	COG2226	methyltransferase
H8F27_RS06715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8F27_RS06745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8F27_RS06750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8F27_RS06765	COG3956	TIGRFAM MazG family protein
H8F27_RS06775	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8F27_RS06790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8F27_RS06795	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8F27_RS06810	COG0783	Belongs to the Dps family
H8F27_RS06815	COG0504	CTP synthase activity
H8F27_RS06820	COG0602	queuosine metabolic process
H8F27_RS06825	COG4574	serine-type endopeptidase inhibitor activity
H8F27_RS06830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8F27_RS06855	COG0411	ABC transporter
H8F27_RS06875	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H8F27_RS06880	COG0830	nickel cation binding
H8F27_RS06885	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H8F27_RS06890	COG0829	nickel cation binding
H8F27_RS06900	COG0832	Belongs to the urease beta subunit family
H8F27_RS06905	COG0804	urea catabolic process
H8F27_RS06910	COG2308	Evidence 4 Homologs of previously reported genes of
H8F27_RS06935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8F27_RS06945	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F27_RS06960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8F27_RS06970	COG0243	molybdopterin cofactor binding
H8F27_RS06975	COG2223	nitrite transmembrane transporter activity
H8F27_RS06995	COG0730	response to heat
H8F27_RS07015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8F27_RS07035	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8F27_RS07045	COG0314	molybdopterin synthase activity
H8F27_RS07065	COG0315	cyclic pyranopterin monophosphate synthase activity
H8F27_RS07075	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8F27_RS07080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F27_RS07085	COG0170	dolichyl monophosphate biosynthetic process
H8F27_RS07090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8F27_RS07095	COG1049	propionate catabolic process, 2-methylcitrate cycle
H8F27_RS07110	COG0788	formyltetrahydrofolate deformylase activity
H8F27_RS07120	COG2022	thiamine diphosphate biosynthetic process
H8F27_RS07120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F27_RS07125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8F27_RS07130	COG0443	Heat shock 70 kDa protein
H8F27_RS07135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F27_RS07145	COG0360	Binds together with S18 to 16S ribosomal RNA
H8F27_RS07155	COG0137	argininosuccinate synthase activity
H8F27_RS07170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F27_RS07195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8F27_RS07200	COG0497	DNA recombination
H8F27_RS07205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F27_RS07215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8F27_RS07220	COG0592	DNA-directed DNA polymerase activity
H8F27_RS07235	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H8F27_RS07240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8F27_RS07250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8F27_RS07265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F27_RS07270	COG0552	protein localization to endoplasmic reticulum
H8F27_RS07275	COG2208	phosphoserine phosphatase activity
H8F27_RS07280	COG0165	Argininosuccinate lyase
H8F27_RS07285	COG0724	RNA recognition motif
H8F27_RS07290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F27_RS07295	COG2081	HI0933 family
H8F27_RS07300	COG1459	type II secretion system
H8F27_RS07310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8F27_RS07315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8F27_RS07320	COG0484	heat shock protein binding
H8F27_RS07330	COG1162	GTPase activity
H8F27_RS07335	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8F27_RS07345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8F27_RS07350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F27_RS07365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F27_RS07375	COG0511	ligase activity, forming carbon-carbon bonds
H8F27_RS07380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8F27_RS07390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8F27_RS07400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F27_RS07450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F27_RS07475	COG1484	DNA-dependent DNA replication
H8F27_RS07495	COG3039	Transposase
H8F27_RS07545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8F27_RS07545	COG0519	Catalyzes the synthesis of GMP from XMP
H8F27_RS07560	COG0768	penicillin binding
H8F27_RS07565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8F27_RS07565	COG0438	transferase activity, transferring glycosyl groups
H8F27_RS07575	COG2022	thiamine diphosphate biosynthetic process
H8F27_RS07590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H8F27_RS07595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H8F27_RS07600	COG2385	sporulation resulting in formation of a cellular spore
H8F27_RS07605	COG1215	transferase activity, transferring glycosyl groups
H8F27_RS07610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H8F27_RS07620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8F27_RS07625	COG0740	serine-type endopeptidase activity
H8F27_RS07630	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8F27_RS07635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8F27_RS07640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8F27_RS07645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H8F27_RS07655	COG0037	tRNA processing
H8F27_RS07670	COG0556	nucleotide-excision repair
H8F27_RS07675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F27_RS07680	COG0527	aspartate kinase activity
H8F27_RS07690	COG2082	Precorrin-8x methylmutase
H8F27_RS07695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8F27_RS07705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8F27_RS07725	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H8F27_RS07740	COG1088	dTDP-glucose 4,6-dehydratase activity
H8F27_RS07830	COG2337	Toxic component of a toxin-antitoxin (TA) module
H8F27_RS07910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8F27_RS08055	COG1216	Glycosyl transferase, family 2
H8F27_RS08100	COG3344	reverse transcriptase
H8F27_RS08195	COG3344	reverse transcriptase
H8F27_RS08200	COG3344	reverse transcriptase
H8F27_RS08325	COG0653	protein targeting
H8F27_RS08340	COG1045	serine acetyltransferase
H8F27_RS08350	COG1725	Transcriptional regulator
H8F27_RS08355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8F27_RS08360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8F27_RS08365	COG0187	DNA topoisomerase II activity
H8F27_RS08365	COG1372	Participates in initiation and elongation during chromosome replication
H8F27_RS08375	COG0386	Belongs to the glutathione peroxidase family
H8F27_RS08380	COG2239	Acts as a magnesium transporter
H8F27_RS08385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F27_RS08390	COG2376	Dihydroxyacetone kinase
H8F27_RS08410	COG0802	atpase or kinase
H8F27_RS08415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8F27_RS08420	COG0629	single-stranded DNA binding
H8F27_RS08445	COG0745	RESPONSE REGULATOR receiver
H8F27_RS08450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8F27_RS08470	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H8F27_RS08475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8F27_RS08485	COG0515	serine threonine protein kinase
H8F27_RS08495	COG2255	four-way junction helicase activity
H8F27_RS08505	COG1473	amidohydrolase
H8F27_RS08520	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8F27_RS08530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8F27_RS08535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8F27_RS08540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8F27_RS08545	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F27_RS08550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8F27_RS08555	COG0662	Cupin 2, conserved barrel domain protein
H8F27_RS08555	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H8F27_RS08560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8F27_RS08570	COG0571	ribonuclease III activity
H8F27_RS08585	COG0582	viral genome integration into host DNA
H8F27_RS08590	COG3617	BRO family, N-terminal domain
H8F27_RS08630	COG1061	Type III restriction enzyme res subunit
H8F27_RS08675	COG2226	methyltransferase
H8F27_RS08795	COG0720	synthase
H8F27_RS08830	COG0343	queuine tRNA-ribosyltransferase activity
H8F27_RS08835	COG0514	ATP-dependent DNA helicase (RecQ)
H8F27_RS08850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8F27_RS08855	COG0602	queuosine metabolic process
H8F27_RS08950	COG0058	SHG alpha-glucan phosphorylase activity
H8F27_RS08955	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H8F27_RS08960	COG0475	glutathione-regulated potassium exporter activity
H8F27_RS08980	COG0277	FAD linked oxidase domain protein
H8F27_RS08995	COG0247	lactate metabolic process
H8F27_RS09000	COG0538	isocitrate dehydrogenase activity
H8F27_RS09020	COG5398	heme oxygenase
H8F27_RS09035	COG0617	tRNA 3'-terminal CCA addition
H8F27_RS09040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H8F27_RS09045	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8F27_RS09050	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8F27_RS09060	COG0709	Synthesizes selenophosphate from selenide and ATP
H8F27_RS09065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8F27_RS09070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8F27_RS09085	COG0124	histidyl-tRNA synthetase
H8F27_RS09095	COG0131	Imidazoleglycerol-phosphate dehydratase
H8F27_RS09100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F27_RS09110	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8F27_RS09135	COG0415	Belongs to the DNA photolyase family
H8F27_RS09140	COG0494	nUDIX hydrolase
H8F27_RS09155	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F27_RS09155	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F27_RS09165	COG3842	ATPase activity
H8F27_RS09170	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H8F27_RS09185	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F27_RS09190	COG1773	rubredoxin
H8F27_RS09195	COG4447	cellulose binding
H8F27_RS09225	COG1519	Transferase
H8F27_RS09230	COG1663	tetraacyldisaccharide 4'-kinase activity
H8F27_RS09235	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F27_RS09240	COG1132	(ABC) transporter
H8F27_RS09245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8F27_RS09250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8F27_RS09255	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H8F27_RS09260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8F27_RS09265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8F27_RS09275	COG0354	folic acid binding
H8F27_RS09280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8F27_RS09295	COG1253	flavin adenine dinucleotide binding
H8F27_RS09300	COG0673	inositol 2-dehydrogenase activity
H8F27_RS09310	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8F27_RS09320	COG0343	queuine tRNA-ribosyltransferase activity
H8F27_RS09330	COG2205	protein histidine kinase activity
H8F27_RS09345	COG0138	bifunctional purine biosynthesis protein purh
H8F27_RS09360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8F27_RS09365	COG1489	DNA binding
H8F27_RS09370	COG0728	peptidoglycan biosynthetic process
H8F27_RS09395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8F27_RS09400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F27_RS09405	COG1058	Belongs to the CinA family
H8F27_RS09405	COG1546	Belongs to the CinA family
H8F27_RS09410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8F27_RS09415	COG0066	3-isopropylmalate dehydratase activity
H8F27_RS09450	COG0193	aminoacyl-tRNA hydrolase activity
H8F27_RS09465	COG4372	Transposase
H8F27_RS09470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F27_RS09480	COG0717	Belongs to the dCTP deaminase family
H8F27_RS09490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8F27_RS09530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8F27_RS09550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8F27_RS09570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8F27_RS09600	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
H8F27_RS09610	COG2094	Belongs to the DNA glycosylase MPG family
H8F27_RS09620	COG0540	Belongs to the ATCase OTCase family
H8F27_RS09635	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H8F27_RS09645	COG3536	Protein conserved in bacteria
H8F27_RS09650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8F27_RS09665	COG2046	Belongs to the sulfate adenylyltransferase family
H8F27_RS09665	COG0529	Catalyzes the synthesis of activated sulfate
H8F27_RS09670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F27_RS09680	COG1943	Transposase
H8F27_RS09725	COG1943	Transposase
H8F27_RS09740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8F27_RS09755	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H8F27_RS09760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F27_RS09770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8F27_RS09775	COG0436	Aminotransferase
H8F27_RS09800	COG1530	ribonuclease E activity
H8F27_RS09805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8F27_RS09815	COG0077	Prephenate dehydratase
H8F27_RS09815	COG1605	Chorismate mutase
H8F27_RS09820	COG2226	methyltransferase
H8F27_RS09830	COG0051	transcription antitermination factor activity, RNA binding
H8F27_RS09835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8F27_RS09840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8F27_RS09845	COG0049	tRNA binding
H8F27_RS09850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8F27_RS09865	COG0070	glutamate synthase
H8F27_RS09865	COG0069	glutamate synthase activity
H8F27_RS09865	COG0067	glutamate synthase
H8F27_RS09870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8F27_RS09890	COG2885	chlorophyll binding
H8F27_RS09895	COG2885	chlorophyll binding
H8F27_RS09915	COG0463	Glycosyl transferase, family 2
H8F27_RS09950	COG1484	DNA-dependent DNA replication
H8F27_RS09960	COG3344	reverse transcriptase
H8F27_RS09970	COG3328	transposase activity
H8F27_RS10040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8F27_RS10050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8F27_RS10055	COG0254	rRNA binding
H8F27_RS10060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8F27_RS10065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H8F27_RS10070	COG0101	tRNA pseudouridine synthase activity
H8F27_RS10080	COG0202	RNA polymerase activity
H8F27_RS10085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H8F27_RS10090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H8F27_RS10095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H8F27_RS10100	COG0563	adenylate kinase activity
H8F27_RS10105	COG0201	protein transport
H8F27_RS10110	COG0200	Binds to the 23S rRNA
H8F27_RS10115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H8F27_RS10125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8F27_RS10130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8F27_RS10135	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8F27_RS10140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8F27_RS10145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H8F27_RS10150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8F27_RS10155	COG0255	Belongs to the universal ribosomal protein uL29 family
H8F27_RS10160	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8F27_RS10165	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8F27_RS10170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H8F27_RS10175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8F27_RS10180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8F27_RS10185	COG0089	rRNA binding
H8F27_RS10190	COG0088	Forms part of the polypeptide exit tunnel
H8F27_RS10195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8F27_RS10210	COG3854	ATPases associated with a variety of cellular activities
H8F27_RS10225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8F27_RS10255	COG3001	Fructosamine kinase
H8F27_RS10275	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H8F27_RS10280	COG1606	tRNA processing
H8F27_RS10285	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8F27_RS10290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8F27_RS10305	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8F27_RS10310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H8F27_RS10315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8F27_RS10330	COG0772	Belongs to the SEDS family
H8F27_RS10335	COG0489	protein tyrosine kinase activity
H8F27_RS10340	COG0408	coproporphyrinogen oxidase activity
H8F27_RS10380	COG3344	reverse transcriptase
H8F27_RS10410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8F27_RS10415	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8F27_RS10420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8F27_RS10420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8F27_RS10425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8F27_RS10440	COG5398	heme oxygenase
H8F27_RS10455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F27_RS10605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8F27_RS10615	COG0539	negative regulation of cytoplasmic translation
H8F27_RS10620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8F27_RS10650	COG0824	Thioesterase
H8F27_RS10660	COG2890	protein-(glutamine-N5) methyltransferase activity
H8F27_RS10685	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8F27_RS10690	COG2894	cell division
H8F27_RS10705	COG2059	Chromate
H8F27_RS10710	COG0850	regulation of cytokinetic process
H8F27_RS10715	COG1078	dGTPase activity
H8F27_RS10720	COG0793	Belongs to the peptidase S41A family
H8F27_RS10725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8F27_RS10730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8F27_RS10760	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8F27_RS10770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8F27_RS10785	COG0514	ATP-dependent DNA helicase (RecQ)
H8F27_RS10790	COG3942	CHAP domain
H8F27_RS10790	COG1388	LysM domain
H8F27_RS10795	COG1012	belongs to the aldehyde dehydrogenase family
H8F27_RS10825	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8F27_RS10865	COG1484	DNA-dependent DNA replication
H8F27_RS10875	COG1230	cation diffusion facilitator family transporter
H8F27_RS10900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F27_RS10910	COG1160	GTP binding
H8F27_RS10915	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H8F27_RS10925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8F27_RS10930	COG1799	cell septum assembly
H8F27_RS10935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8F27_RS10940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H8F27_RS10955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8F27_RS10960	COG2211	Major facilitator Superfamily
H8F27_RS10975	COG1569	PIN domain
H8F27_RS10980	COG3311	Transcriptional regulator
H8F27_RS11080	COG1061	Type III restriction enzyme res subunit
H8F27_RS11130	COG0840	transmembrane signaling receptor activity
H8F27_RS11160	COG0674	pyruvate-flavodoxin oxidoreductase activity
H8F27_RS11160	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H8F27_RS11160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8F27_RS11160	COG1013	pyruvate-flavodoxin oxidoreductase activity
H8F27_RS11175	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H8F27_RS11195	COG0375	protein maturation
H8F27_RS11305	COG3259	Nickel-dependent hydrogenase
H8F27_RS11355	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
H8F27_RS11385	COG0776	regulation of translation
H8F27_RS11395	COG1523	belongs to the glycosyl hydrolase 13 family
H8F27_RS11425	COG1484	DNA-dependent DNA replication
H8F27_RS11505	COG1484	DNA-dependent DNA replication
H8F27_RS11585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H8F27_RS11590	COG1218	3'(2'),5'-bisphosphate nucleotidase
H8F27_RS11595	COG1185	polyribonucleotide nucleotidyltransferase activity
H8F27_RS11605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8F27_RS11610	COG0750	zinc metalloprotease
H8F27_RS11615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8F27_RS11625	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8F27_RS11690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F27_RS11705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H8F27_RS11710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8F27_RS11710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F27_RS11720	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F27_RS11730	COG0107	imidazoleglycerol-phosphate synthase activity
H8F27_RS11740	COG2226	methyltransferase
H8F27_RS11745	COG5001	Diguanylate cyclase
H8F27_RS11750	COG0752	glycyl-tRNA synthetase alpha subunit
H8F27_RS11830	COG1484	DNA-dependent DNA replication
H8F27_RS11850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H8F27_RS11860	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H8F27_RS11865	COG0732	type I restriction modification DNA specificity domain
H8F27_RS11870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F27_RS11925	COG1435	thymidine kinase activity
H8F27_RS11960	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8F27_RS11965	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8F27_RS11980	COG0740	serine-type endopeptidase activity
H8F27_RS11985	COG0740	serine-type endopeptidase activity
H8F27_RS12000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8F27_RS12010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H8F27_RS12025	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8F27_RS12030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F27_RS12035	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H8F27_RS12035	COG2066	Belongs to the glutaminase family
H8F27_RS12040	COG4948	Mandelate Racemase Muconate Lactonizing
H8F27_RS12080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8F27_RS12085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8F27_RS12090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8F27_RS12105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F27_RS12110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F27_RS12115	COG0134	indole-3-glycerol-phosphate synthase activity
H8F27_RS12120	COG0644	oxidoreductase
H8F27_RS12130	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8F27_RS12140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8F27_RS12145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8F27_RS12165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F27_RS12175	COG0706	membrane insertase activity
H8F27_RS12185	COG0594	ribonuclease P activity
H8F27_RS12190	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H8F27_RS12205	COG0616	signal peptide processing
H8F27_RS12210	COG0697	spore germination
H8F27_RS12230	COG2337	Toxic component of a toxin-antitoxin (TA) module
H8F27_RS12280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H8F27_RS12290	COG1842	Phage shock protein A
H8F27_RS12295	COG3118	belongs to the thioredoxin family
H8F27_RS12300	COG0436	Aminotransferase
H8F27_RS12310	COG0739	heme binding
H8F27_RS12360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F27_RS12375	COG1136	(ABC) transporter
H8F27_RS12375	COG0577	efflux transmembrane transporter activity
H8F27_RS12385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8F27_RS12400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8F27_RS12435	COG1845	cytochrome c oxidase, subunit III
H8F27_RS12440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8F27_RS12470	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H8F27_RS12475	COG0459	protein refolding
H8F27_RS12485	COG1028	Short-chain dehydrogenase reductase Sdr
H8F27_RS12495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8F27_RS12500	COG1619	proteins homologs of microcin C7 resistance protein MccF
H8F27_RS12505	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F27_RS12510	COG0248	Ppx GppA phosphatase
H8F27_RS12525	COG0579	oxidoreductase
H8F27_RS12535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8F27_RS12540	COG3258	Cytochrome c
H8F27_RS12545	COG0723	plastoquinol--plastocyanin reductase activity
H8F27_RS12555	COG0805	protein transport
H8F27_RS12565	COG0194	GDP metabolic process
H8F27_RS12580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8F27_RS12585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F27_RS12605	COG0012	GTP binding
H8F27_RS12615	COG2337	Toxic component of a toxin-antitoxin (TA) module
H8F27_RS12645	COG0601	transmembrane transport
H8F27_RS12660	COG0460	homoserine dehydrogenase
H8F27_RS12665	COG2166	iron-sulfur cluster assembly
H8F27_RS12680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8F27_RS12685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8F27_RS12690	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H8F27_RS12710	COG2010	Cytochrome c
H8F27_RS12725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8F27_RS12730	COG1611	Belongs to the LOG family
H8F27_RS12735	COG3118	belongs to the thioredoxin family
H8F27_RS12740	COG0516	GMP reductase activity
H8F27_RS12755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8F27_RS12770	COG0644	oxidoreductase
H8F27_RS12775	COG1543	Belongs to the glycosyl hydrolase 57 family
H8F27_RS12780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8F27_RS12785	COG0395	ABC-type sugar transport system, permease component
H8F27_RS12815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8F27_RS12835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8F27_RS12845	COG1233	COG1233 Phytoene dehydrogenase and related
H8F27_RS12855	COG0076	glutamate decarboxylase activity
H8F27_RS12880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8F27_RS12885	COG0271	Belongs to the BolA IbaG family
H8F27_RS12900	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8F27_RS12915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8F27_RS12920	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H8F27_RS12925	COG1074	ATP-dependent DNA helicase activity
H8F27_RS12930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F27_RS12940	COG0513	Belongs to the DEAD box helicase family
H8F27_RS12955	COG0724	RNA recognition motif
H8F27_RS12960	COG1132	(ABC) transporter
H8F27_RS12970	COG1285	pathogenesis
H8F27_RS13005	COG1484	DNA-dependent DNA replication
H8F27_RS13035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8F27_RS13040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8F27_RS13130	COG2119	membrane
H8F27_RS13135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F27_RS13150	COG1053	succinate dehydrogenase
H8F27_RS13160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8F27_RS13185	COG0358	DNA primase activity
H8F27_RS13200	COG0632	four-way junction helicase activity
H8F27_RS13205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8F27_RS13215	COG0587	DNA-directed DNA polymerase activity
H8F27_RS13220	COG0154	amidase activity
H8F27_RS13230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F27_RS13235	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H8F27_RS13245	COG0505	Belongs to the CarA family
H8F27_RS13250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8F27_RS13260	COG1132	(ABC) transporter
H8F27_RS13270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F27_RS13305	COG3039	Transposase
H8F27_RS13335	COG1132	(ABC) transporter
H8F27_RS13375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F27_RS13400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F27_RS13450	COG3344	reverse transcriptase
H8F27_RS13470	COG0438	transferase activity, transferring glycosyl groups
H8F27_RS13520	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H8F27_RS13525	COG0515	serine threonine protein kinase
H8F27_RS13545	COG2226	methyltransferase
H8F27_RS13555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F27_RS13630	COG3344	reverse transcriptase
H8F27_RS13650	COG3328	transposase activity
H8F27_RS13655	COG0297	glycogen (starch) synthase activity
H8F27_RS13670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8F27_RS13690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8F27_RS13695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8F27_RS13715	COG0612	Peptidase, M16
H8F27_RS13725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F27_RS13745	COG1216	Glycosyl transferase, family 2
H8F27_RS13750	COG0052	Belongs to the universal ribosomal protein uS2 family
H8F27_RS13755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8F27_RS13765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8F27_RS13770	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8F27_RS13775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F27_RS13780	COG0751	glycine-tRNA ligase activity
H8F27_RS13785	COG0644	oxidoreductase
H8F27_RS13795	COG1217	gtp-binding protein TYPA
H8F27_RS13810	COG1137	ATPase activity
H8F27_RS13820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8F27_RS13825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H8F27_RS13830	COG1494	fructose-1,6-bisphosphatase
H8F27_RS13835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8F27_RS13840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8F27_RS13845	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H8F27_RS13850	COG0363	glucosamine-6-phosphate deaminase activity
H8F27_RS13865	COG0129	dihydroxy-acid dehydratase activity
H8F27_RS13875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8F27_RS13910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8F27_RS13915	COG0047	phosphoribosylformylglycinamidine synthase activity
H8F27_RS13920	COG0450	alkyl hydroperoxide reductase
H8F27_RS13940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8F27_RS13970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F27_RS13980	COG0557	exoribonuclease II activity
H8F27_RS13985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8F27_RS13990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H8F27_RS13995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F27_RS13995	COG0072	phenylalanine-tRNA ligase activity
H8F27_RS14000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8F27_RS14025	COG1191	sigma factor activity
H8F27_RS14035	COG2385	sporulation resulting in formation of a cellular spore
H8F27_RS14045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8F27_RS14070	COG0646	methionine synthase
H8F27_RS14070	COG1410	methionine synthase
H8F27_RS14075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8F27_RS14090	COG0613	PHP domain protein
H8F27_RS14095	COG1981	membrane
H8F27_RS14100	COG3046	protein related to deoxyribodipyrimidine photolyase
H8F27_RS14115	COG0322	excinuclease ABC activity
H8F27_RS14120	COG0426	domain, Protein
H8F27_RS14120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F27_RS14125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8F27_RS14155	COG1104	cysteine desulfurase activity
H8F27_RS14160	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8F27_RS14170	COG0495	leucyl-tRNA aminoacylation
H8F27_RS14185	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8F27_RS14230	COG0166	Belongs to the GPI family
H8F27_RS14245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F27_RS14255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8F27_RS14260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8F27_RS14265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8F27_RS14265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8F27_RS14270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F27_RS14275	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8F27_RS14280	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H8F27_RS14290	COG0484	heat shock protein binding
H8F27_RS14300	COG0573	inorganic phosphate transmembrane transporter activity
H8F27_RS14305	COG0581	inorganic phosphate transmembrane transporter activity
H8F27_RS14310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8F27_RS14320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F27_RS14325	COG0483	inositol monophosphate 1-phosphatase activity
H8F27_RS14330	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H8F27_RS14350	COG0326	Molecular chaperone. Has ATPase activity
H8F27_RS14360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H8F27_RS14365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F27_RS14390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8F27_RS14395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8F27_RS14420	COG0469	pyruvate kinase activity
H8F27_RS14425	COG1136	(ABC) transporter
H8F27_RS14425	COG0577	efflux transmembrane transporter activity
H8F27_RS14435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F27_RS14440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F27_RS14445	COG0740	serine-type endopeptidase activity
H8F27_RS14460	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H8F27_RS14475	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8F27_RS14490	COG0778	Nitroreductase
H8F27_RS14500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H8F27_RS14505	COG1175	transmembrane transport
H8F27_RS14515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8F27_RS14550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F27_RS14580	COG0651	ATP synthesis coupled electron transport
H8F27_RS14620	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
H8F27_RS14640	COG5001	Diguanylate cyclase
H8F27_RS14650	COG0516	GMP reductase activity
H8F27_RS14710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8F27_RS14745	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8F27_RS14785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8F27_RS14795	COG2197	response regulator
H8F27_RS14800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8F27_RS14805	COG0114	fumarate hydratase activity
H8F27_RS14815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8F27_RS14825	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8F27_RS14840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8F27_RS14855	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8F27_RS14860	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F27_RS14865	COG0473	3-isopropylmalate dehydrogenase activity
H8F27_RS14870	COG3954	Phosphoribulokinase
H8F27_RS14880	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8F27_RS14885	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8F27_RS14895	COG0673	inositol 2-dehydrogenase activity
H8F27_RS14900	COG0191	fructose-bisphosphate aldolase activity
H8F27_RS14915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8F27_RS14920	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8F27_RS14930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8F27_RS14955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8F27_RS14955	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H8F27_RS14985	COG0557	exoribonuclease II activity
H8F27_RS14990	COG0163	prenyltransferase activity
H8F27_RS15005	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H8F27_RS15010	COG0312	modulator of DNA gyrase
H8F27_RS15020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8F27_RS15030	COG0513	Belongs to the DEAD box helicase family
H8F27_RS15040	COG0861	Integral membrane protein TerC family
H8F27_RS15060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8F27_RS15085	COG0793	Belongs to the peptidase S41A family
H8F27_RS15090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8F27_RS15095	COG1573	uracil-dna glycosylase
H8F27_RS15100	COG0436	Aminotransferase
H8F27_RS15105	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H8F27_RS15115	COG4413	Urea transporter
H8F27_RS15140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8F27_RS15140	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H8F27_RS15145	COG3639	organic phosphonate transmembrane transporter activity
H8F27_RS15155	COG1191	sigma factor activity
H8F27_RS15160	COG1836	PFAM Integral membrane protein DUF92
H8F27_RS15170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8F27_RS15180	COG1122	ATPase activity
H8F27_RS15185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8F27_RS15200	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8F27_RS15205	COG4106	trans-aconitate 2-methyltransferase activity
H8F27_RS15210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8F27_RS15305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F27_RS15320	COG0121	glutamine amidotransferase
H8F27_RS15325	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8F27_RS15330	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8F27_RS15350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8F27_RS15360	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H8F27_RS15365	COG4208	sulfate ABC transporter
H8F27_RS15405	COG1598	PFAM Uncharacterised protein family UPF0150
H8F27_RS15455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F27_RS15475	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H8F27_RS15525	COG1484	DNA-dependent DNA replication
H8F27_RS15535	COG5002	protein histidine kinase activity
H8F27_RS15535	COG5001	Diguanylate cyclase
H8F27_RS15560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8F27_RS15565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F27_RS15570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8F27_RS15590	COG0745	RESPONSE REGULATOR receiver
H8F27_RS15680	COG1741	Belongs to the pirin family
H8F27_RS15740	COG5002	protein histidine kinase activity
H8F27_RS15745	COG0745	RESPONSE REGULATOR receiver
H8F27_RS15780	COG1201	RNA secondary structure unwinding
H8F27_RS15795	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F27_RS15800	COG3657	addiction module killer protein
H8F27_RS15805	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8F27_RS15805	COG1793	dna ligase
H8F27_RS15825	COG0625	glutathione transferase activity
H8F27_RS15885	COG2124	cytochrome p450
H8F27_RS15895	COG2890	protein-(glutamine-N5) methyltransferase activity
H8F27_RS15930	COG3328	transposase activity
H8F27_RS15965	COG3328	transposase activity
H8F27_RS15975	COG0659	secondary active sulfate transmembrane transporter activity
H8F27_RS15985	COG0011	TIGRFAM Protein of
H8F27_RS16000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F27_RS16020	COG0647	UMP catabolic process
H8F27_RS16025	COG1484	DNA-dependent DNA replication
H8F27_RS16125	COG1484	DNA-dependent DNA replication
H8F27_RS16220	COG1484	DNA-dependent DNA replication
H8F27_RS16230	COG0210	DNA helicase
H8F27_RS16240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F27_RS16265	COG1484	DNA-dependent DNA replication
H8F27_RS16390	COG1525	nuclease
H8F27_RS16405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F27_RS16410	COG1484	DNA-dependent DNA replication
H8F27_RS16440	COG3550	peptidyl-serine autophosphorylation
H8F27_RS16465	COG0210	DNA helicase
H8F27_RS16480	COG1715	Restriction endonuclease
H8F27_RS16610	COG0352	thiamine-phosphate diphosphorylase activity
H8F27_RS16645	COG1484	DNA-dependent DNA replication
H8F27_RS16675	COG1819	glycosyl
H8F27_RS16685	COG0463	Glycosyl transferase, family 2
H8F27_RS16715	COG1525	nuclease
H8F27_RS16805	COG1111	helicase
H8F27_RS16805	COG1205	dead DEAH box helicase
H8F27_RS16810	COG0210	DNA helicase
H8F27_RS16820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F27_RS16860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F27_RS16880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F27_RS16975	COG1518	maintenance of DNA repeat elements
H8F27_RS16975	COG1468	defense response to virus
H8F27_RS17110	COG1468	defense response to virus
H8F27_RS17110	COG1518	maintenance of DNA repeat elements
H8F27_RS17210	COG1484	DNA-dependent DNA replication
H8F27_RS17295	COG0251	oxidation-reduction process
H8F27_RS17300	COG3842	ATPase activity
H8F27_RS17305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8F27_RS17310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8F27_RS17315	COG1132	(ABC) transporter
H8F27_RS17320	COG0456	acetyltransferase
H8F27_RS17340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain