locus-tag	class	description
SYNC_RS00015	COG0592	DNA-directed DNA polymerase activity
SYNC_RS00025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYNC_RS00030	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYNC_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYNC_RS00045	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SYNC_RS00060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYNC_RS00065	COG0552	protein localization to endoplasmic reticulum
SYNC_RS00070	COG2208	phosphoserine phosphatase activity
SYNC_RS00075	COG0165	Argininosuccinate lyase
SYNC_RS00080	COG0724	RNA recognition motif
SYNC_RS00085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYNC_RS00090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNC_RS00095	COG2081	HI0933 family
SYNC_RS00105	COG1459	type II secretion system
SYNC_RS00115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYNC_RS00120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SYNC_RS00125	COG0484	heat shock protein binding
SYNC_RS00135	COG1162	GTPase activity
SYNC_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SYNC_RS00145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SYNC_RS00150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SYNC_RS00155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYNC_RS00160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SYNC_RS00165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNC_RS00170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SYNC_RS00175	COG0511	ligase activity, forming carbon-carbon bonds
SYNC_RS00180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SYNC_RS00205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYNC_RS00250	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SYNC_RS00255	COG0519	Catalyzes the synthesis of GMP from XMP
SYNC_RS00255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SYNC_RS00285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYNC_RS00285	COG0438	transferase activity, transferring glycosyl groups
SYNC_RS00290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNC_RS00300	COG2022	thiamine diphosphate biosynthetic process
SYNC_RS00315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SYNC_RS00320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SYNC_RS00325	COG2385	sporulation resulting in formation of a cellular spore
SYNC_RS00330	COG1215	transferase activity, transferring glycosyl groups
SYNC_RS00335	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYNC_RS00345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SYNC_RS00350	COG0740	serine-type endopeptidase activity
SYNC_RS00355	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYNC_RS00360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SYNC_RS00365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SYNC_RS00370	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SYNC_RS00380	COG0037	tRNA processing
SYNC_RS00395	COG0556	nucleotide-excision repair
SYNC_RS00415	COG2082	Precorrin-8x methylmutase
SYNC_RS00420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SYNC_RS00430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SYNC_RS00450	COG0438	transferase activity, transferring glycosyl groups
SYNC_RS00455	COG0653	protein targeting
SYNC_RS00460	COG1045	serine acetyltransferase
SYNC_RS00465	COG1725	Transcriptional regulator
SYNC_RS00475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SYNC_RS00480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYNC_RS00485	COG0187	DNA topoisomerase II activity
SYNC_RS00485	COG1372	Participates in initiation and elongation during chromosome replication
SYNC_RS00495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SYNC_RS00500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SYNC_RS00505	COG0386	Belongs to the glutathione peroxidase family
SYNC_RS00510	COG2239	Acts as a magnesium transporter
SYNC_RS00515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNC_RS00520	COG0596	Alpha beta hydrolase
SYNC_RS00525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SYNC_RS00530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYNC_RS00535	COG1194	a g-specific adenine glycosylase
SYNC_RS00540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SYNC_RS00550	COG0174	glutamine synthetase
SYNC_RS00560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SYNC_RS00565	COG0802	atpase or kinase
SYNC_RS00570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SYNC_RS00575	COG0586	Pfam SNARE associated Golgi protein
SYNC_RS00580	COG0629	single-stranded DNA binding
SYNC_RS00590	COG1792	Involved in formation and maintenance of cell shape
SYNC_RS00610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SYNC_RS00630	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SYNC_RS00635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SYNC_RS00640	COG0515	serine threonine protein kinase
SYNC_RS00640	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNC_RS00645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SYNC_RS00650	COG2255	four-way junction helicase activity
SYNC_RS00660	COG1473	amidohydrolase
SYNC_RS00675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SYNC_RS00680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SYNC_RS00685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYNC_RS00690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYNC_RS00700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SYNC_RS00745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYNC_RS00755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SYNC_RS00765	COG0489	protein tyrosine kinase activity
SYNC_RS00770	COG0671	phosphoesterase, PA-phosphatase related
SYNC_RS00770	COG2453	phosphatase
SYNC_RS00835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SYNC_RS00850	COG2089	acid synthase
SYNC_RS00860	COG0107	imidazoleglycerol-phosphate synthase activity
SYNC_RS00870	COG0367	asparagine synthase
SYNC_RS00875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYNC_RS00890	COG1083	cytidylyl-transferase
SYNC_RS00895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SYNC_RS00915	COG1028	Short-chain dehydrogenase reductase Sdr
SYNC_RS00930	COG0471	metal ion transport
SYNC_RS00930	COG3273	potassium ion transport
SYNC_RS00935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SYNC_RS00945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNC_RS00960	COG0571	ribonuclease III activity
SYNC_RS00970	COG1970	mechanosensitive ion channel activity
SYNC_RS00985	COG0058	SHG alpha-glucan phosphorylase activity
SYNC_RS00990	COG0475	glutathione-regulated potassium exporter activity
SYNC_RS01010	COG0277	FAD linked oxidase domain protein
SYNC_RS01025	COG0247	lactate metabolic process
SYNC_RS01030	COG0538	isocitrate dehydrogenase activity
SYNC_RS01040	COG5398	heme oxygenase
SYNC_RS01050	COG1132	(ABC) transporter
SYNC_RS01055	COG0438	transferase activity, transferring glycosyl groups
SYNC_RS01060	COG0438	transferase activity, transferring glycosyl groups
SYNC_RS01065	COG0438	transferase activity, transferring glycosyl groups
SYNC_RS01070	COG0438	transferase activity, transferring glycosyl groups
SYNC_RS01095	COG0617	tRNA 3'-terminal CCA addition
SYNC_RS01105	COG0709	Synthesizes selenophosphate from selenide and ATP
SYNC_RS01110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNC_RS01115	COG0124	histidyl-tRNA synthetase
SYNC_RS01120	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SYNC_RS01155	COG4447	cellulose binding
SYNC_RS01160	COG1773	rubredoxin
SYNC_RS01165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNC_RS01170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNC_RS01175	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNC_RS01180	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SYNC_RS01185	COG3842	ATPase activity
SYNC_RS01190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SYNC_RS01195	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNC_RS01195	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNC_RS01200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SYNC_RS01210	COG0415	Belongs to the DNA photolyase family
SYNC_RS01240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SYNC_RS01245	COG3781	membrane
SYNC_RS01250	COG0131	Imidazoleglycerol-phosphate dehydratase
SYNC_RS01255	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SYNC_RS01265	COG5002	protein histidine kinase activity
SYNC_RS01265	COG3850	Histidine kinase
SYNC_RS01275	COG0745	RESPONSE REGULATOR receiver
SYNC_RS01290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SYNC_RS01310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SYNC_RS01315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYNC_RS01325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYNC_RS01340	COG1253	flavin adenine dinucleotide binding
SYNC_RS01345	COG0673	inositol 2-dehydrogenase activity
SYNC_RS01360	COG0343	queuine tRNA-ribosyltransferase activity
SYNC_RS01365	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SYNC_RS01370	COG2205	protein histidine kinase activity
SYNC_RS01390	COG0138	bifunctional purine biosynthesis protein purh
SYNC_RS01405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SYNC_RS01410	COG0004	ammonium transporteR
SYNC_RS01415	COG1489	DNA binding
SYNC_RS01420	COG0728	peptidoglycan biosynthetic process
SYNC_RS01445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SYNC_RS01450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYNC_RS01455	COG1058	Belongs to the CinA family
SYNC_RS01455	COG1546	Belongs to the CinA family
SYNC_RS01460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYNC_RS01465	COG0066	3-isopropylmalate dehydratase activity
SYNC_RS01500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYNC_RS01505	COG0193	aminoacyl-tRNA hydrolase activity
SYNC_RS01520	COG4372	Transposase
SYNC_RS01525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNC_RS01530	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SYNC_RS01540	COG0717	Belongs to the dCTP deaminase family
SYNC_RS01550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYNC_RS01570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYNC_RS01585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SYNC_RS01610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SYNC_RS01630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYNC_RS01640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SYNC_RS01645	COG2094	Belongs to the DNA glycosylase MPG family
SYNC_RS01650	COG0540	Belongs to the ATCase OTCase family
SYNC_RS01685	COG3536	Protein conserved in bacteria
SYNC_RS01690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SYNC_RS01700	COG2046	Belongs to the sulfate adenylyltransferase family
SYNC_RS01700	COG0529	Catalyzes the synthesis of activated sulfate
SYNC_RS01705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNC_RS01720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SYNC_RS01730	COG0463	Glycosyl transferase, family 2
SYNC_RS01735	COG0366	Alpha amylase catalytic
SYNC_RS01750	COG0284	orotidine-5'-phosphate decarboxylase activity
SYNC_RS01750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SYNC_RS01770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNC_RS01780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYNC_RS01785	COG0436	Aminotransferase
SYNC_RS01795	COG1530	ribonuclease E activity
SYNC_RS01800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SYNC_RS01810	COG1605	Chorismate mutase
SYNC_RS01810	COG0077	Prephenate dehydratase
SYNC_RS01815	COG2226	methyltransferase
SYNC_RS01820	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYNC_RS01825	COG0051	transcription antitermination factor activity, RNA binding
SYNC_RS01830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SYNC_RS01835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYNC_RS01840	COG0049	tRNA binding
SYNC_RS01845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SYNC_RS01860	COG0070	glutamate synthase
SYNC_RS01860	COG0069	glutamate synthase activity
SYNC_RS01860	COG0067	glutamate synthase
SYNC_RS01870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYNC_RS01890	COG2885	chlorophyll binding
SYNC_RS01895	COG2885	chlorophyll binding
SYNC_RS01905	COG3239	Fatty acid desaturase
SYNC_RS01930	COG0463	Glycosyl transferase, family 2
SYNC_RS01950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SYNC_RS01960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYNC_RS01965	COG0254	rRNA binding
SYNC_RS01970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SYNC_RS01975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SYNC_RS01980	COG0101	tRNA pseudouridine synthase activity
SYNC_RS01985	COG0203	ribosomal protein L17
SYNC_RS01990	COG0202	RNA polymerase activity
SYNC_RS01995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SYNC_RS02000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SYNC_RS02010	COG0563	adenylate kinase activity
SYNC_RS02015	COG0201	protein transport
SYNC_RS02020	COG0200	Binds to the 23S rRNA
SYNC_RS02025	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SYNC_RS02030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SYNC_RS02035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SYNC_RS02040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SYNC_RS02045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SYNC_RS02050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SYNC_RS02055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SYNC_RS02060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SYNC_RS02065	COG0255	Belongs to the universal ribosomal protein uL29 family
SYNC_RS02070	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SYNC_RS02075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SYNC_RS02080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SYNC_RS02085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SYNC_RS02090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SYNC_RS02095	COG0089	rRNA binding
SYNC_RS02100	COG0088	Forms part of the polypeptide exit tunnel
SYNC_RS02105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SYNC_RS02120	COG3854	ATPases associated with a variety of cellular activities
SYNC_RS02135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SYNC_RS02155	COG0287	Prephenate dehydrogenase
SYNC_RS02165	COG3001	Fructosamine kinase
SYNC_RS02185	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SYNC_RS02190	COG1606	tRNA processing
SYNC_RS02195	COG0076	glutamate decarboxylase activity
SYNC_RS02200	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SYNC_RS02205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SYNC_RS02220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SYNC_RS02230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYNC_RS02245	COG0772	Belongs to the SEDS family
SYNC_RS02250	COG0489	protein tyrosine kinase activity
SYNC_RS02255	COG0408	coproporphyrinogen oxidase activity
SYNC_RS02300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNC_RS02315	COG0667	Aldo Keto reductase
SYNC_RS02325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SYNC_RS02330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SYNC_RS02335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SYNC_RS02335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SYNC_RS02340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYNC_RS02465	COG0237	dephospho-CoA kinase activity
SYNC_RS02485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNC_RS02540	COG1070	Carbohydrate kinase
SYNC_RS02545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SYNC_RS02555	COG0539	negative regulation of cytoplasmic translation
SYNC_RS02560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYNC_RS02585	COG0589	response to stress
SYNC_RS02600	COG2890	protein-(glutamine-N5) methyltransferase activity
SYNC_RS02605	COG0009	L-threonylcarbamoyladenylate synthase
SYNC_RS02615	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SYNC_RS02620	COG2894	cell division
SYNC_RS02625	COG0850	regulation of cytokinetic process
SYNC_RS02630	COG1078	dGTPase activity
SYNC_RS02635	COG0793	Belongs to the peptidase S41A family
SYNC_RS02640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SYNC_RS02645	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SYNC_RS02685	COG0659	secondary active sulfate transmembrane transporter activity
SYNC_RS02690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SYNC_RS02705	COG0514	ATP-dependent DNA helicase (RecQ)
SYNC_RS02715	COG1012	belongs to the aldehyde dehydrogenase family
SYNC_RS02725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SYNC_RS02730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SYNC_RS02775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SYNC_RS02800	COG2197	response regulator
SYNC_RS02805	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SYNC_RS02825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYNC_RS02840	COG1376	ErfK ybiS ycfS ynhG family protein
SYNC_RS02845	COG1160	GTP binding
SYNC_RS02850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SYNC_RS02860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SYNC_RS02865	COG1799	cell septum assembly
SYNC_RS02870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SYNC_RS02875	COG0438	transferase activity, transferring glycosyl groups
SYNC_RS02885	COG1381	Involved in DNA repair and RecF pathway recombination
SYNC_RS02890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SYNC_RS02895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SYNC_RS02900	COG0321	lipoyl(octanoyl) transferase activity
SYNC_RS02905	COG1022	Amp-dependent synthetase and ligase
SYNC_RS02975	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYNC_RS02980	COG0531	amino acid
SYNC_RS02985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SYNC_RS02990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYNC_RS03000	COG0626	cystathionine gamma-synthase activity
SYNC_RS03035	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SYNC_RS03040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SYNC_RS03050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYNC_RS03070	COG1104	cysteine desulfurase activity
SYNC_RS03095	COG0657	acetylesterase activity
SYNC_RS03110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SYNC_RS03115	COG0579	oxidoreductase
SYNC_RS03120	COG0371	Dehydrogenase
SYNC_RS03135	COG0481	GTPase activity
SYNC_RS03210	COG0745	RESPONSE REGULATOR receiver
SYNC_RS03245	COG5002	protein histidine kinase activity
SYNC_RS03260	COG3659	wide pore channel activity
SYNC_RS03270	COG1528	Iron-storage protein
SYNC_RS03275	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SYNC_RS03315	COG0678	peroxiredoxin activity
SYNC_RS03320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNC_RS03335	COG3695	enzyme binding
SYNC_RS03340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SYNC_RS03340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYNC_RS03345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYNC_RS03350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYNC_RS03360	COG0107	imidazoleglycerol-phosphate synthase activity
SYNC_RS03370	COG2226	methyltransferase
SYNC_RS03400	COG5002	protein histidine kinase activity
SYNC_RS03440	COG0752	glycyl-tRNA synthetase alpha subunit
SYNC_RS03470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SYNC_RS03475	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SYNC_RS03480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SYNC_RS03485	COG0740	serine-type endopeptidase activity
SYNC_RS03490	COG0740	serine-type endopeptidase activity
SYNC_RS03495	COG4956	integral membrane protein (PIN domain superfamily)
SYNC_RS03500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYNC_RS03505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SYNC_RS03510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SYNC_RS03525	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYNC_RS03530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNC_RS03535	COG4948	Mandelate Racemase Muconate Lactonizing
SYNC_RS03570	COG0285	dihydrofolate synthase activity
SYNC_RS03575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYNC_RS03585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYNC_RS03600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNC_RS03605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYNC_RS03610	COG0134	indole-3-glycerol-phosphate synthase activity
SYNC_RS03620	COG0681	Belongs to the peptidase S26 family
SYNC_RS03640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SYNC_RS03645	COG0482	sulfurtransferase activity
SYNC_RS03650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SYNC_RS03650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SYNC_RS03655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNC_RS03670	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYNC_RS03675	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SYNC_RS03685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SYNC_RS03690	COG0228	four-way junction DNA binding
SYNC_RS03695	COG1702	phosphate starvation-inducible protein PhoH
SYNC_RS03705	COG0477	Major facilitator Superfamily
SYNC_RS03715	COG3527	Alpha-acetolactate decarboxylase
SYNC_RS03720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SYNC_RS03730	COG0336	Belongs to the RNA methyltransferase TrmD family
SYNC_RS03740	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SYNC_RS03750	COG1691	(AIR) carboxylase
SYNC_RS03770	COG0352	thiamine-phosphate diphosphorylase activity
SYNC_RS03775	COG0196	riboflavin kinase activity
SYNC_RS03785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYNC_RS03790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SYNC_RS03805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNC_RS03815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYNC_RS03820	COG0745	RESPONSE REGULATOR receiver
SYNC_RS03880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYNC_RS03880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYNC_RS03885	COG0656	L-ascorbic acid biosynthetic process
SYNC_RS03895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNC_RS03900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SYNC_RS03905	COG2267	carboxylic ester hydrolase activity
SYNC_RS03920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYNC_RS04050	COG4948	Mandelate Racemase Muconate Lactonizing
SYNC_RS04105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYNC_RS04130	COG0477	Major facilitator Superfamily
SYNC_RS04145	COG0432	Pfam Uncharacterised protein family UPF0047
SYNC_RS04190	COG1492	cobalamin metabolic process
SYNC_RS04200	COG0424	maF-like protein
SYNC_RS04225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNC_RS04230	COG0440	acetolactate synthase activity
SYNC_RS04235	COG2267	carboxylic ester hydrolase activity
SYNC_RS04265	COG1187	pseudouridine synthase activity
SYNC_RS04275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SYNC_RS04325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SYNC_RS04330	COG0733	neurotransmitter:sodium symporter activity
SYNC_RS04345	COG0215	cysteine-tRNA ligase activity
SYNC_RS04365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYNC_RS04365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYNC_RS04370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYNC_RS04375	COG0012	GTP binding
SYNC_RS04405	COG0601	transmembrane transport
SYNC_RS04420	COG0460	homoserine dehydrogenase
SYNC_RS04425	COG2166	iron-sulfur cluster assembly
SYNC_RS04445	COG0288	reversible hydration of carbon dioxide
SYNC_RS04500	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SYNC_RS04505	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNC_RS04520	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SYNC_RS04525	COG2010	Cytochrome c
SYNC_RS04535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SYNC_RS04540	COG3118	belongs to the thioredoxin family
SYNC_RS04545	COG0516	GMP reductase activity
SYNC_RS04555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYNC_RS04560	COG0644	oxidoreductase
SYNC_RS04565	COG1543	Belongs to the glycosyl hydrolase 57 family
SYNC_RS04570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYNC_RS04575	COG0395	ABC-type sugar transport system, permease component
SYNC_RS04590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYNC_RS04630	COG0564	pseudouridine synthase activity
SYNC_RS04635	COG1480	7TM receptor with intracellular HD hydrolase
SYNC_RS04640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SYNC_RS04645	COG0142	geranyltranstransferase activity
SYNC_RS04670	COG0406	alpha-ribazole phosphatase activity
SYNC_RS04675	COG1254	Belongs to the acylphosphatase family
SYNC_RS04680	COG1797	cobyrinic acid a,c-diamide synthase activity
SYNC_RS04685	COG3429	Glucose-6-phosphate dehydrogenase subunit
SYNC_RS04685	COG3409	Peptidoglycan-binding domain 1 protein
SYNC_RS04690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SYNC_RS04710	COG2205	protein histidine kinase activity
SYNC_RS04725	COG0308	aminopeptidase N
SYNC_RS04735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SYNC_RS04755	COG1640	4-alpha-glucanotransferase
SYNC_RS04765	COG1187	pseudouridine synthase activity
SYNC_RS04770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNC_RS04780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNC_RS04785	COG1982	Orn Lys Arg decarboxylase major
SYNC_RS04790	COG0575	Belongs to the CDS family
SYNC_RS04800	COG0596	Alpha beta hydrolase
SYNC_RS04805	COG0371	Dehydrogenase
SYNC_RS04810	COG0542	response to heat
SYNC_RS04815	COG0456	acetyltransferase
SYNC_RS04820	COG0019	diaminopimelate decarboxylase activity
SYNC_RS04825	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SYNC_RS04830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SYNC_RS04835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYNC_RS04845	COG1054	Belongs to the UPF0176 family
SYNC_RS04860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYNC_RS04865	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SYNC_RS04900	COG0589	response to stress
SYNC_RS04900	COG0475	glutathione-regulated potassium exporter activity
SYNC_RS04905	COG1132	(ABC) transporter
SYNC_RS04910	COG0724	RNA recognition motif
SYNC_RS04920	COG0513	Belongs to the DEAD box helicase family
SYNC_RS04925	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SYNC_RS04925	COG0662	Cupin 2, conserved barrel domain protein
SYNC_RS04930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SYNC_RS04935	COG1074	ATP-dependent DNA helicase activity
SYNC_RS04940	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SYNC_RS04960	COG0385	Bile acid
SYNC_RS05240	COG2205	protein histidine kinase activity
SYNC_RS05245	COG0745	RESPONSE REGULATOR receiver
SYNC_RS05255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYNC_RS05265	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SYNC_RS05290	COG0745	RESPONSE REGULATOR receiver
SYNC_RS05295	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SYNC_RS05300	COG0271	Belongs to the BolA IbaG family
SYNC_RS05315	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SYNC_RS05350	COG0625	glutathione transferase activity
SYNC_RS05380	COG0735	belongs to the Fur family
SYNC_RS05390	COG1799	cell septum assembly
SYNC_RS05405	COG0625	glutathione transferase activity
SYNC_RS05450	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SYNC_RS05475	COG1126	abc transporter atp-binding protein
SYNC_RS05480	COG0765	amino acid transport
SYNC_RS05490	COG4597	amino acid ABC transporter
SYNC_RS05495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYNC_RS05505	COG0659	secondary active sulfate transmembrane transporter activity
SYNC_RS05560	COG0799	negative regulation of ribosome biogenesis
SYNC_RS05570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYNC_RS05580	COG1115	amino acid carrier protein
SYNC_RS05590	COG1132	(ABC) transporter
SYNC_RS05600	COG0149	triose-phosphate isomerase activity
SYNC_RS05605	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SYNC_RS05625	COG1132	(ABC) transporter
SYNC_RS05645	COG0745	RESPONSE REGULATOR receiver
SYNC_RS05650	COG1429	ligase activity, forming nitrogen-metal bonds
SYNC_RS05655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SYNC_RS05665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNC_RS05670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SYNC_RS05680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SYNC_RS05785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNC_RS05845	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SYNC_RS05850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNC_RS05865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SYNC_RS05875	COG4106	trans-aconitate 2-methyltransferase activity
SYNC_RS05880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SYNC_RS05895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SYNC_RS05900	COG1122	ATPase activity
SYNC_RS05910	COG0052	Belongs to the universal ribosomal protein uS2 family
SYNC_RS05915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SYNC_RS05925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SYNC_RS05930	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SYNC_RS05935	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYNC_RS05940	COG0751	glycine-tRNA ligase activity
SYNC_RS05945	COG0644	oxidoreductase
SYNC_RS05955	COG0826	peptidase U32
SYNC_RS05960	COG1217	gtp-binding protein TYPA
SYNC_RS05985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYNC_RS06010	COG0861	Integral membrane protein TerC family
SYNC_RS06030	COG0513	Belongs to the DEAD box helicase family
SYNC_RS06035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SYNC_RS06045	COG0312	modulator of DNA gyrase
SYNC_RS06050	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYNC_RS06065	COG0163	prenyltransferase activity
SYNC_RS06070	COG0557	exoribonuclease II activity
SYNC_RS06080	COG2119	membrane
SYNC_RS06100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYNC_RS06100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYNC_RS06120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SYNC_RS06125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNC_RS06130	COG1615	UPF0182 protein
SYNC_RS06135	COG0450	alkyl hydroperoxide reductase
SYNC_RS06150	COG0739	heme binding
SYNC_RS06155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SYNC_RS06190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNC_RS06205	COG0557	exoribonuclease II activity
SYNC_RS06210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SYNC_RS06215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SYNC_RS06220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNC_RS06220	COG0072	phenylalanine-tRNA ligase activity
SYNC_RS06225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SYNC_RS06250	COG1191	sigma factor activity
SYNC_RS06260	COG2385	sporulation resulting in formation of a cellular spore
SYNC_RS06285	COG0646	methionine synthase
SYNC_RS06285	COG1410	methionine synthase
SYNC_RS06290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYNC_RS06305	COG0613	PHP domain protein
SYNC_RS06310	COG1981	membrane
SYNC_RS06315	COG3046	protein related to deoxyribodipyrimidine photolyase
SYNC_RS06325	COG0322	excinuclease ABC activity
SYNC_RS06330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SYNC_RS06355	COG1104	cysteine desulfurase activity
SYNC_RS06360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SYNC_RS06385	COG0495	leucyl-tRNA aminoacylation
SYNC_RS06390	COG0166	Belongs to the GPI family
SYNC_RS06415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SYNC_RS06420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SYNC_RS06425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYNC_RS06425	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYNC_RS06430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNC_RS06435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SYNC_RS06440	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SYNC_RS06450	COG0484	heat shock protein binding
SYNC_RS06455	COG0443	Heat shock 70 kDa protein
SYNC_RS06460	COG0573	inorganic phosphate transmembrane transporter activity
SYNC_RS06465	COG0581	inorganic phosphate transmembrane transporter activity
SYNC_RS06470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYNC_RS06480	COG0633	Ferredoxin
SYNC_RS06485	COG0483	inositol monophosphate 1-phosphatase activity
SYNC_RS06490	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SYNC_RS06500	COG0326	Molecular chaperone. Has ATPase activity
SYNC_RS06505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SYNC_RS06510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYNC_RS06515	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SYNC_RS06520	COG1653	transport
SYNC_RS06535	COG3842	ATPase activity
SYNC_RS06560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SYNC_RS06565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SYNC_RS06585	COG0469	pyruvate kinase activity
SYNC_RS06590	COG1136	(ABC) transporter
SYNC_RS06590	COG0577	efflux transmembrane transporter activity
SYNC_RS06595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNC_RS06600	COG0740	serine-type endopeptidase activity
SYNC_RS06620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYNC_RS06625	COG2211	Major facilitator Superfamily
SYNC_RS06645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SYNC_RS06650	COG1175	transmembrane transport
SYNC_RS06655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SYNC_RS06685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SYNC_RS06690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SYNC_RS06690	COG1793	dna ligase
SYNC_RS06695	COG1793	dna ligase
SYNC_RS06700	COG1201	RNA secondary structure unwinding
SYNC_RS06770	COG0484	heat shock protein binding
SYNC_RS06795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYNC_RS06800	COG2124	cytochrome p450
SYNC_RS06805	COG2264	protein methyltransferase activity
SYNC_RS06830	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SYNC_RS06880	COG3829	transcription factor binding
SYNC_RS06940	COG2132	Multicopper oxidase
SYNC_RS06950	COG3961	Belongs to the TPP enzyme family
SYNC_RS06970	COG4232	protein-disulfide reductase activity
SYNC_RS06975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYNC_RS06980	COG1121	(ABC) transporter
SYNC_RS06985	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYNC_RS06990	COG3659	wide pore channel activity
SYNC_RS06995	COG3659	wide pore channel activity
SYNC_RS07030	COG0523	cobalamin synthesis protein
SYNC_RS07050	COG3300	MHYT domain
SYNC_RS07050	COG5001	Diguanylate cyclase
SYNC_RS07105	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SYNC_RS07115	COG1376	ErfK ybiS ycfS ynhG family protein
SYNC_RS07120	COG0297	glycogen (starch) synthase activity
SYNC_RS07130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SYNC_RS07140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SYNC_RS07160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SYNC_RS07165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNC_RS07175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNC_RS07185	COG3659	wide pore channel activity
SYNC_RS07195	COG3128	pkhd-type hydroxylase
SYNC_RS07200	COG1840	ABC-type Fe3 transport system, periplasmic component
SYNC_RS07205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SYNC_RS07210	COG2045	Belongs to the ComB family
SYNC_RS07225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SYNC_RS07230	COG0142	geranyltranstransferase activity
SYNC_RS07235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SYNC_RS07240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYNC_RS07255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYNC_RS07260	COG2176	DNA-directed DNA polymerase activity
SYNC_RS07280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SYNC_RS07285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SYNC_RS07305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SYNC_RS07315	COG0174	glutamine synthetase
SYNC_RS07350	COG2226	methyltransferase
SYNC_RS07375	COG0515	serine threonine protein kinase
SYNC_RS07380	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SYNC_RS07390	COG0628	permease
SYNC_RS07400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNC_RS07400	COG0426	domain, Protein
SYNC_RS07410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYNC_RS07415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYNC_RS07420	COG0022	dehydrogenase e1 component
SYNC_RS07420	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYNC_RS07430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SYNC_RS07435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SYNC_RS07445	COG0792	nuclease activity
SYNC_RS07465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SYNC_RS07490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYNC_RS07500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SYNC_RS07520	COG0358	DNA primase activity
SYNC_RS07560	COG0632	four-way junction helicase activity
SYNC_RS07565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SYNC_RS07575	COG0587	DNA-directed DNA polymerase activity
SYNC_RS07580	COG0154	amidase activity
SYNC_RS07590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNC_RS07595	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SYNC_RS07600	COG1366	Belongs to the anti-sigma-factor antagonist family
SYNC_RS07605	COG0505	Belongs to the CarA family
SYNC_RS07610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYNC_RS07615	COG1132	(ABC) transporter
SYNC_RS07625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNC_RS07665	COG0612	Peptidase, M16
SYNC_RS07700	COG1136	(ABC) transporter
SYNC_RS07705	COG1216	Glycosyl transferase, family 2
SYNC_RS07720	COG1836	PFAM Integral membrane protein DUF92
SYNC_RS07725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNC_RS07735	COG3639	organic phosphonate transmembrane transporter activity
SYNC_RS07740	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SYNC_RS07740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYNC_RS07745	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SYNC_RS07750	COG0436	Aminotransferase
SYNC_RS07760	COG1573	uracil-dna glycosylase
SYNC_RS07765	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SYNC_RS07770	COG0793	Belongs to the peptidase S41A family
SYNC_RS07785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SYNC_RS07800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SYNC_RS07805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SYNC_RS07810	COG1494	fructose-1,6-bisphosphatase
SYNC_RS07815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SYNC_RS07820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNC_RS07825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SYNC_RS07830	COG0363	glucosamine-6-phosphate deaminase activity
SYNC_RS07845	COG0129	dihydroxy-acid dehydratase activity
SYNC_RS07855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SYNC_RS07885	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYNC_RS07890	COG0047	phosphoribosylformylglycinamidine synthase activity
SYNC_RS07895	COG1619	proteins homologs of microcin C7 resistance protein MccF
SYNC_RS07900	COG0191	fructose-bisphosphate aldolase activity
SYNC_RS07905	COG3588	fructose-bisphosphate aldolase
SYNC_RS07910	COG0673	inositol 2-dehydrogenase activity
SYNC_RS07920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SYNC_RS07925	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SYNC_RS07935	COG3954	Phosphoribulokinase
SYNC_RS07940	COG0473	3-isopropylmalate dehydrogenase activity
SYNC_RS07945	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYNC_RS07950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SYNC_RS07965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SYNC_RS07980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYNC_RS07985	COG2197	response regulator
SYNC_RS07995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SYNC_RS08010	COG0517	IMP dehydrogenase activity
SYNC_RS08020	COG1376	ErfK ybiS ycfS ynhG family protein
SYNC_RS08045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SYNC_RS08100	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYNC_RS08110	COG1121	(ABC) transporter
SYNC_RS08125	COG0701	Predicted permease
SYNC_RS08130	COG2010	Cytochrome c
SYNC_RS08145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYNC_RS08150	COG1121	(ABC) transporter
SYNC_RS08190	COG2032	superoxide dismutase activity
SYNC_RS08330	COG0730	response to heat
SYNC_RS08370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNC_RS08440	COG3781	membrane
SYNC_RS08445	COG1012	belongs to the aldehyde dehydrogenase family
SYNC_RS08510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SYNC_RS08515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNC_RS08565	COG0180	Tryptophanyl-tRNA synthetase
SYNC_RS08580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SYNC_RS08590	COG0837	glucose binding
SYNC_RS08595	COG0083	homoserine kinase activity
SYNC_RS08600	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNC_RS08605	COG0339	signal peptide processing
SYNC_RS08635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SYNC_RS08640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYNC_RS08680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SYNC_RS08685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SYNC_RS08695	COG3794	PFAM blue (type 1) copper domain protein
SYNC_RS08730	COG0542	response to heat
SYNC_RS08740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SYNC_RS08740	COG0140	phosphoribosyl-ATP diphosphatase activity
SYNC_RS08755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNC_RS08795	COG0159	tryptophan synthase activity
SYNC_RS08850	COG0418	dihydroorotase activity
SYNC_RS08855	COG0659	secondary active sulfate transmembrane transporter activity
SYNC_RS08880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SYNC_RS08885	COG1845	cytochrome c oxidase, subunit III
SYNC_RS08895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYNC_RS08905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SYNC_RS08910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNC_RS08925	COG0456	acetyltransferase
SYNC_RS08935	COG1132	(ABC) transporter
SYNC_RS08940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SYNC_RS08945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYNC_RS08955	COG0251	oxidation-reduction process
SYNC_RS08985	COG0492	ferredoxin-NADP+ reductase activity
SYNC_RS08990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYNC_RS09005	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNC_RS09010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYNC_RS09015	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNC_RS09040	COG4451	ribulose bisphosphate carboxylase, small
SYNC_RS09045	COG1850	ribulose-bisphosphate carboxylase activity
SYNC_RS09050	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNC_RS09055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SYNC_RS09060	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNC_RS09075	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYNC_RS09080	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYNC_RS09085	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SYNC_RS09115	COG0730	response to heat
SYNC_RS09120	COG0095	Lipoate-protein ligase
SYNC_RS09125	COG1994	Peptidase M50
SYNC_RS09125	COG0517	IMP dehydrogenase activity
SYNC_RS09130	COG0135	phosphoribosylanthranilate isomerase activity
SYNC_RS09140	COG0302	gtp cyclohydrolase
SYNC_RS09150	COG0825	malonyl-CoA metabolic process
SYNC_RS09155	COG5322	oxidoreductase activity
SYNC_RS09160	COG3396	Phenylacetate-CoA oxygenase
SYNC_RS09170	COG0539	negative regulation of cytoplasmic translation
SYNC_RS09185	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SYNC_RS09200	COG0028	Belongs to the TPP enzyme family
SYNC_RS09205	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNC_RS09210	COG0582	viral genome integration into host DNA
SYNC_RS09215	COG2226	methyltransferase
SYNC_RS09225	COG0528	UMP kinase activity
SYNC_RS09230	COG0233	cytoplasmic translational termination
SYNC_RS09240	COG0415	Belongs to the DNA photolyase family
SYNC_RS09245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SYNC_RS09250	COG0768	penicillin binding
SYNC_RS09265	COG0588	phosphoglycerate mutase activity
SYNC_RS09275	COG0681	Belongs to the peptidase S26 family
SYNC_RS09285	COG1393	Belongs to the ArsC family
SYNC_RS09295	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SYNC_RS09310	COG0442	prolyl-tRNA aminoacylation
SYNC_RS09320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SYNC_RS09325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SYNC_RS09335	COG0629	single-stranded DNA binding
SYNC_RS09350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SYNC_RS09360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SYNC_RS09365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNC_RS09380	COG0181	hydroxymethylbilane synthase activity
SYNC_RS09395	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SYNC_RS09400	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SYNC_RS09420	COG2154	pterin-4-alpha-carbinolamine dehydratase
SYNC_RS09425	COG0523	cobalamin synthesis protein
SYNC_RS09440	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SYNC_RS09465	COG0708	Exodeoxyribonuclease III
SYNC_RS09470	COG0277	FAD linked oxidase domain protein
SYNC_RS09475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SYNC_RS09490	COG1666	GTP binding
SYNC_RS09545	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNC_RS09585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SYNC_RS09590	COG1218	3'(2'),5'-bisphosphate nucleotidase
SYNC_RS09595	COG1185	polyribonucleotide nucleotidyltransferase activity
SYNC_RS09600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SYNC_RS09605	COG0750	zinc metalloprotease
SYNC_RS09610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SYNC_RS09615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNC_RS09625	COG0706	membrane insertase activity
SYNC_RS09635	COG0594	ribonuclease P activity
SYNC_RS09640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SYNC_RS09655	COG0616	signal peptide processing
SYNC_RS09660	COG0697	spore germination
SYNC_RS09680	COG1842	Phage shock protein A
SYNC_RS09685	COG3118	belongs to the thioredoxin family
SYNC_RS09690	COG0436	Aminotransferase
SYNC_RS09695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SYNC_RS09695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SYNC_RS09700	COG0739	heme binding
SYNC_RS09705	COG0745	RESPONSE REGULATOR receiver
SYNC_RS09710	COG1136	(ABC) transporter
SYNC_RS09710	COG0577	efflux transmembrane transporter activity
SYNC_RS09715	COG1007	ATP synthesis coupled electron transport
SYNC_RS09720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SYNC_RS09735	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SYNC_RS09770	COG1845	cytochrome c oxidase, subunit III
SYNC_RS09775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SYNC_RS09785	COG1612	heme a metabolic process
SYNC_RS09790	COG0109	protoheme IX farnesyltransferase activity
SYNC_RS09810	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SYNC_RS09820	COG0459	protein refolding
SYNC_RS09825	COG1028	Short-chain dehydrogenase reductase Sdr
SYNC_RS09830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SYNC_RS09840	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SYNC_RS09845	COG1619	proteins homologs of microcin C7 resistance protein MccF
SYNC_RS09850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYNC_RS09855	COG0248	Ppx GppA phosphatase
SYNC_RS09875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SYNC_RS09880	COG0739	heme binding
SYNC_RS09885	COG0723	plastoquinol--plastocyanin reductase activity
SYNC_RS09895	COG0805	protein transport
SYNC_RS09900	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SYNC_RS09905	COG0194	GDP metabolic process
SYNC_RS09920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SYNC_RS09925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNC_RS09935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SYNC_RS09955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYNC_RS09975	COG0335	large ribosomal subunit rRNA binding
SYNC_RS09985	COG0024	Methionine aminopeptidase
SYNC_RS09990	COG0300	oxidoreductase activity
SYNC_RS09990	COG3000	fatty acid hydroxylase
SYNC_RS09995	COG0857	belongs to the CobB CobQ family
SYNC_RS10060	COG0776	regulation of translation
SYNC_RS10080	COG2211	Major facilitator Superfamily
SYNC_RS10085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYNC_RS10100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SYNC_RS10105	COG0284	orotidine-5'-phosphate decarboxylase activity
SYNC_RS10110	COG3386	PFAM SMP-30 Gluconolaconase
SYNC_RS10120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYNC_RS10130	COG2197	response regulator
SYNC_RS10145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SYNC_RS10155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNC_RS10165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYNC_RS10170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYNC_RS10175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SYNC_RS10185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SYNC_RS10195	COG0151	Belongs to the GarS family
SYNC_RS10200	COG5002	protein histidine kinase activity
SYNC_RS10205	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SYNC_RS10210	COG4251	negative regulation of phosphorylation
SYNC_RS10220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SYNC_RS10225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SYNC_RS10260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNC_RS10265	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SYNC_RS10270	COG0217	transcriptional regulatory protein
SYNC_RS10305	COG0363	glucosamine-6-phosphate deaminase activity
SYNC_RS10310	COG2385	sporulation resulting in formation of a cellular spore
SYNC_RS10310	COG2247	cell wall binding repeat
SYNC_RS10315	COG1234	tRNA 3'-trailer cleavage
SYNC_RS10320	COG2010	Cytochrome c
SYNC_RS10345	COG2264	protein methyltransferase activity
SYNC_RS10350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SYNC_RS10370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SYNC_RS10430	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SYNC_RS10435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SYNC_RS10455	COG0459	protein refolding
SYNC_RS10460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYNC_RS10465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SYNC_RS10470	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SYNC_RS10480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SYNC_RS10490	COG0387	Pfam Sodium calcium exchanger
SYNC_RS10495	COG0006	proline dipeptidase activity
SYNC_RS10500	COG1253	flavin adenine dinucleotide binding
SYNC_RS10505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNC_RS10510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SYNC_RS10515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SYNC_RS10515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNC_RS10520	COG0686	Belongs to the AlaDH PNT family
SYNC_RS10575	COG3012	SEC-C Motif Domain Protein
SYNC_RS10580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNC_RS10590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYNC_RS10600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SYNC_RS10605	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYNC_RS10610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYNC_RS10615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYNC_RS10620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYNC_RS10625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYNC_RS10630	COG0356	it plays a direct role in the translocation of protons across the membrane
SYNC_RS10640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNC_RS10645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNC_RS10665	COG0772	Belongs to the SEDS family
SYNC_RS10675	COG1333	cytochrome c biogenesis protein
SYNC_RS10680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SYNC_RS10690	COG0347	Belongs to the P(II) protein family
SYNC_RS10705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SYNC_RS10715	COG0114	fumarate hydratase activity
SYNC_RS10720	COG4581	dead DEAH box helicase
SYNC_RS10725	COG0156	8-amino-7-oxononanoate synthase activity
SYNC_RS10735	COG2226	methyltransferase
SYNC_RS10740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SYNC_RS10745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SYNC_RS10755	COG0484	heat shock protein binding
SYNC_RS10760	COG0357	Ribosomal RNA small subunit methyltransferase G
SYNC_RS10795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SYNC_RS10805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYNC_RS10810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYNC_RS10815	COG0085	RNA polymerase activity
SYNC_RS10820	COG0084	hydrolase, TatD family'
SYNC_RS10825	COG0268	Binds directly to 16S ribosomal RNA
SYNC_RS10830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SYNC_RS10835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SYNC_RS10840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNC_RS10850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYNC_RS10850	COG2205	protein histidine kinase activity
SYNC_RS10860	COG0641	radical SAM
SYNC_RS10870	COG0779	Required for maturation of 30S ribosomal subunits
SYNC_RS10875	COG0195	Participates in both transcription termination and antitermination
SYNC_RS10885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYNC_RS10900	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SYNC_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
SYNC_RS10950	COG2988	succinylglutamate desuccinylase activity
SYNC_RS10955	COG0435	Glutathione S-transferase
SYNC_RS10965	COG0488	(ABC) transporter
SYNC_RS10975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYNC_RS10980	COG3842	ATPase activity
SYNC_RS10985	COG1193	negative regulation of DNA recombination
SYNC_RS10995	COG0113	porphobilinogen synthase activity
SYNC_RS11000	COG0484	heat shock protein binding
SYNC_RS11010	COG0659	secondary active sulfate transmembrane transporter activity
SYNC_RS11110	COG2124	cytochrome p450
SYNC_RS11220	COG0116	Belongs to the methyltransferase superfamily
SYNC_RS11240	COG1196	nuclear chromosome segregation
SYNC_RS11250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNC_RS11265	COG0439	Biotin carboxylase
SYNC_RS11280	COG0515	serine threonine protein kinase
SYNC_RS11300	COG4178	(ABC) transporter
SYNC_RS11305	COG0537	adenosine 5'-monophosphoramidase activity
SYNC_RS11310	COG0606	chelatase, subunit chli
SYNC_RS11315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SYNC_RS11330	COG0242	peptide deformylase activity
SYNC_RS11340	COG0235	Class ii aldolase
SYNC_RS11345	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYNC_RS11355	COG2226	methyltransferase
SYNC_RS11360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYNC_RS11365	COG0719	Fe-S assembly protein
SYNC_RS11370	COG0396	ATPase activity
SYNC_RS11375	COG0719	Fe-S assembly protein
SYNC_RS11380	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SYNC_RS11400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNC_RS11415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SYNC_RS11440	COG2814	Major facilitator Superfamily
SYNC_RS11450	COG0033	Phosphoglucomutase
SYNC_RS11465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYNC_RS11485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYNC_RS11490	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SYNC_RS11495	COG0175	sulfate reduction
SYNC_RS11500	COG1252	NADH dehydrogenase
SYNC_RS11505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SYNC_RS11510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SYNC_RS11515	COG0569	domain protein
SYNC_RS11520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SYNC_RS11545	COG0488	(ABC) transporter
SYNC_RS11555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNC_RS11570	COG1643	Atp-dependent helicase
SYNC_RS11580	COG1570	exodeoxyribonuclease VII activity
SYNC_RS11630	COG0483	inositol monophosphate 1-phosphatase activity
SYNC_RS11645	COG1968	undecaprenyl-diphosphatase activity
SYNC_RS11655	COG1555	photosystem II stabilization
SYNC_RS11660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SYNC_RS11665	COG4243	Vitamin k epoxide reductase
SYNC_RS11670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNC_RS11685	COG1032	radical SAM domain protein
SYNC_RS11740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SYNC_RS11750	COG0463	Glycosyl transferase, family 2
SYNC_RS11750	COG0457	Tetratricopeptide repeat
SYNC_RS11755	COG1587	Uroporphyrinogen-III synthase
SYNC_RS11770	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYNC_RS11775	COG0316	Belongs to the HesB IscA family
SYNC_RS11795	COG1090	epimerase
SYNC_RS11810	COG0484	heat shock protein binding
SYNC_RS11815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYNC_RS11820	COG3659	wide pore channel activity
SYNC_RS11825	COG3659	wide pore channel activity
SYNC_RS11860	COG1122	ATPase activity
SYNC_RS11875	COG0745	RESPONSE REGULATOR receiver
SYNC_RS11885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SYNC_RS11890	COG2217	Heavy metal translocating P-type atpase
SYNC_RS11895	COG3063	Type IV pilus biogenesis stability protein PilW
SYNC_RS11900	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SYNC_RS11910	COG0416	fatty acid biosynthetic process
SYNC_RS11915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYNC_RS11920	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SYNC_RS11925	COG0204	Acyl-transferase
SYNC_RS11925	COG0318	PFAM AMP-dependent synthetase and ligase
SYNC_RS11935	COG1214	PFAM Peptidase M22, glycoprotease
SYNC_RS11945	COG0617	tRNA 3'-terminal CCA addition
SYNC_RS11955	COG1562	ergosterol biosynthetic process
SYNC_RS11960	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYNC_RS11960	COG0493	'glutamate synthase
SYNC_RS11975	COG0583	DNA-binding transcription factor activity
SYNC_RS11985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYNC_RS11990	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNC_RS12005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYNC_RS12015	COG2197	response regulator
SYNC_RS12025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYNC_RS12030	COG0713	ATP synthesis coupled electron transport
SYNC_RS12035	COG0839	Belongs to the complex I subunit 6 family
SYNC_RS12040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNC_RS12045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SYNC_RS12050	COG0372	Belongs to the citrate synthase family
SYNC_RS12070	COG1420	regulation of RNA biosynthetic process
SYNC_RS12085	COG0133	tryptophan synthase activity
SYNC_RS12095	COG0023	Translation Initiation Factor
SYNC_RS12100	COG0529	Catalyzes the synthesis of activated sulfate
SYNC_RS12105	COG0628	permease
SYNC_RS12110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SYNC_RS12120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNC_RS12125	COG0564	pseudouridine synthase activity
SYNC_RS12130	COG0745	RESPONSE REGULATOR receiver
SYNC_RS12155	COG0275	rRNA processing
SYNC_RS12160	COG0649	NAD binding
SYNC_RS12170	COG0824	Thioesterase
SYNC_RS12185	COG0318	PFAM AMP-dependent synthetase and ligase
SYNC_RS12195	COG1575	Belongs to the MenA family. Type 1 subfamily
SYNC_RS12205	COG0189	ligase activity
SYNC_RS12210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SYNC_RS12215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SYNC_RS12225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SYNC_RS12230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SYNC_RS12235	COG0512	Glutamine amidotransferase of anthranilate synthase
SYNC_RS12245	COG0252	asparaginase activity
SYNC_RS12250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYNC_RS12255	COG0018	arginyl-trna synthetase
SYNC_RS12265	COG1454	alcohol dehydrogenase
SYNC_RS12280	COG5001	Diguanylate cyclase
SYNC_RS12330	COG0154	amidase activity
SYNC_RS12365	COG0668	transmembrane transport
SYNC_RS12385	COG0157	Belongs to the NadC ModD family
SYNC_RS12405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNC_RS12415	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SYNC_RS12420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYNC_RS12425	COG4172	Belongs to the ABC transporter superfamily
SYNC_RS12435	COG0564	pseudouridine synthase activity
SYNC_RS12445	COG0589	response to stress
SYNC_RS12450	COG0126	phosphoglycerate kinase activity
SYNC_RS12460	COG2084	Dehydrogenase
SYNC_RS12470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYNC_RS12475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYNC_RS12485	COG1450	Type ii and iii secretion system protein
SYNC_RS12505	COG0167	dihydroorotate dehydrogenase activity
SYNC_RS12510	COG0328	RNA-DNA hybrid ribonuclease activity
SYNC_RS12520	COG0222	ribosome binding
SYNC_RS12525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SYNC_RS12530	COG0081	regulation of translation
SYNC_RS12535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SYNC_RS12540	COG0250	Participates in transcription elongation, termination and antitermination
SYNC_RS12545	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SYNC_RS12550	COG0542	response to heat
SYNC_RS12555	COG0346	lactoylglutathione lyase activity
SYNC_RS12560	COG0148	phosphopyruvate hydratase activity
SYNC_RS12565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNC_RS12580	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SYNC_RS12585	COG0237	dephospho-CoA kinase activity
SYNC_RS12595	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYNC_RS12600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNC_RS12600	COG2022	thiamine diphosphate biosynthetic process
SYNC_RS12605	COG0105	UTP biosynthetic process
SYNC_RS12610	COG1166	arginine decarboxylase activity
SYNC_RS12695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SYNC_RS12705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYNC_RS12730	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SYNC_RS12740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SYNC_RS12745	COG0426	domain, Protein
SYNC_RS12745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNC_RS12750	COG0426	domain, Protein
SYNC_RS12750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNC_RS12755	COG1773	rubredoxin
SYNC_RS12765	COG1741	Belongs to the pirin family
SYNC_RS12785	COG0509	glycine decarboxylation via glycine cleavage system
SYNC_RS12790	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SYNC_RS12810	COG0359	binds to the 23S rRNA
SYNC_RS12815	COG0305	Participates in initiation and elongation during chromosome replication
SYNC_RS12815	COG1372	Participates in initiation and elongation during chromosome replication
SYNC_RS12815	COG0305	Participates in initiation and elongation during chromosome replication
SYNC_RS12815	COG1372	Participates in initiation and elongation during chromosome replication
SYNC_RS12820	COG0445	tRNA wobble uridine modification
SYNC_RS12865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYNC_RS12875	COG0398	Pfam SNARE associated Golgi protein
SYNC_RS12885	COG0668	transmembrane transport
SYNC_RS12900	COG1131	(ABC) transporter
SYNC_RS12910	COG3264	Mechanosensitive ion channel
SYNC_RS12910	COG1196	nuclear chromosome segregation
SYNC_RS12920	COG3300	MHYT domain
SYNC_RS12920	COG5001	Diguanylate cyclase
SYNC_RS12935	COG0668	transmembrane transport
SYNC_RS12940	COG0525	valine-tRNA ligase activity
SYNC_RS12965	COG4221	oxidoreductase activity
SYNC_RS12990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNC_RS13020	COG3956	TIGRFAM MazG family protein
SYNC_RS13040	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SYNC_RS13045	COG0010	Belongs to the arginase family
SYNC_RS13050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYNC_RS13055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYNC_RS13060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNC_RS13065	COG0783	Belongs to the Dps family
SYNC_RS13075	COG0504	CTP synthase activity
SYNC_RS13080	COG0602	queuosine metabolic process
SYNC_RS13105	COG4574	serine-type endopeptidase inhibitor activity
SYNC_RS13110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SYNC_RS13125	COG0531	amino acid
SYNC_RS13155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SYNC_RS13160	COG0830	nickel cation binding
SYNC_RS13165	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SYNC_RS13170	COG0829	nickel cation binding
SYNC_RS13175	COG0831	urea catabolic process
SYNC_RS13180	COG0832	Belongs to the urease beta subunit family
SYNC_RS13185	COG0804	urea catabolic process
SYNC_RS13190	COG0505	Belongs to the CarA family
SYNC_RS13195	COG2308	Evidence 4 Homologs of previously reported genes of
SYNC_RS13215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYNC_RS13220	COG0746	molybdenum cofactor guanylyltransferase activity
SYNC_RS13225	COG2223	nitrite transmembrane transporter activity
SYNC_RS13230	COG0243	molybdopterin cofactor binding
SYNC_RS13245	COG0315	cyclic pyranopterin monophosphate synthase activity
SYNC_RS13250	COG0303	'Molybdopterin
SYNC_RS13255	COG0314	molybdopterin synthase activity
SYNC_RS13265	COG0521	Mo-molybdopterin cofactor biosynthetic process
SYNC_RS13270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYNC_RS13280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYNC_RS13285	COG2116	formate transmembrane transporter activity
SYNC_RS13295	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SYNC_RS13305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYNC_RS13315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SYNC_RS13320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNC_RS13325	COG0170	dolichyl monophosphate biosynthetic process
SYNC_RS13330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SYNC_RS13335	COG1049	propionate catabolic process, 2-methylcitrate cycle
SYNC_RS13360	COG0788	formyltetrahydrofolate deformylase activity
SYNC_RS13370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNC_RS13380	COG2755	lipolytic protein G-D-S-L family
SYNC_RS13380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SYNC_RS13390	COG0443	Heat shock 70 kDa protein
SYNC_RS13395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SYNC_RS13405	COG0360	Binds together with S18 to 16S ribosomal RNA
SYNC_RS13415	COG0137	argininosuccinate synthase activity
SYNC_RS13430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYNC_RS13450	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SYNC_RS13455	COG0438	transferase activity, transferring glycosyl groups
SYNC_RS13465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SYNC_RS13470	COG0497	DNA recombination
SYNC_RS13475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNC_RS13485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SYNC_RS13495	COG3321	synthase
SYNC_RS13495	COG0604	alcohol dehydrogenase
SYNC_RS13495	COG1028	Short-chain dehydrogenase reductase Sdr
SYNC_RS13500	COG2089	acid synthase
SYNC_RS13520	COG4968	Prepilin-type N-terminal cleavage methylation domain
SYNC_RS13550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNC_RS13570	COG3706	GGDEF domain
SYNC_RS13615	COG1404	Belongs to the peptidase S8 family