locus-tag	class	description
CYA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYA_RS00015	COG2226	methyltransferase
CYA_RS00020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_RS00025	COG0300	oxidoreductase activity
CYA_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYA_RS00040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYA_RS00050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CYA_RS00065	COG0515	serine threonine protein kinase
CYA_RS00085	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CYA_RS00095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CYA_RS00100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CYA_RS00105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CYA_RS00110	COG0012	GTP binding
CYA_RS00115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYA_RS00125	COG0633	Ferredoxin
CYA_RS00140	COG0735	belongs to the Fur family
CYA_RS00200	COG0515	serine threonine protein kinase
CYA_RS00220	COG0482	sulfurtransferase activity
CYA_RS00245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYA_RS00265	COG0709	Synthesizes selenophosphate from selenide and ATP
CYA_RS00270	COG0587	DNA-directed DNA polymerase activity
CYA_RS00350	COG0644	oxidoreductase
CYA_RS00360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYA_RS00365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYA_RS00375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CYA_RS00385	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYA_RS00395	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CYA_RS00400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYA_RS00410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CYA_RS00425	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CYA_RS00425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CYA_RS00430	COG1968	undecaprenyl-diphosphatase activity
CYA_RS00460	COG2226	methyltransferase
CYA_RS00480	COG0438	transferase activity, transferring glycosyl groups
CYA_RS00485	COG2208	phosphoserine phosphatase activity
CYA_RS00495	COG0165	Argininosuccinate lyase
CYA_RS00505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CYA_RS00515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYA_RS00520	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYA_RS00530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYA_RS00540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYA_RS00560	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CYA_RS00590	COG0724	RNA recognition motif
CYA_RS00595	COG0420	3'-5' exonuclease activity
CYA_RS00605	COG1166	arginine decarboxylase activity
CYA_RS00615	COG0443	Heat shock 70 kDa protein
CYA_RS00620	COG0484	heat shock protein binding
CYA_RS00625	COG0247	lactate metabolic process
CYA_RS00635	COG1022	Amp-dependent synthetase and ligase
CYA_RS00675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYA_RS00680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYA_RS00695	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CYA_RS00700	COG2884	Cell division ATP-binding protein ftsE
CYA_RS00705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYA_RS00715	COG0601	transmembrane transport
CYA_RS00720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYA_RS00725	COG1126	abc transporter atp-binding protein
CYA_RS00735	COG2177	Part of the ABC transporter FtsEX involved in
CYA_RS00770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CYA_RS00790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYA_RS00795	COG2226	methyltransferase
CYA_RS00800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYA_RS00810	COG0314	molybdopterin synthase activity
CYA_RS00815	COG0746	molybdenum cofactor guanylyltransferase activity
CYA_RS00815	COG0315	cyclic pyranopterin monophosphate synthase activity
CYA_RS00820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CYA_RS00825	COG0303	'Molybdopterin
CYA_RS00845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CYA_RS00855	COG0542	response to heat
CYA_RS00860	COG0557	exoribonuclease II activity
CYA_RS00865	COG0704	Plays a role in the regulation of phosphate uptake
CYA_RS00890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CYA_RS00910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CYA_RS00915	COG1132	(ABC) transporter
CYA_RS00920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CYA_RS00925	COG0505	Belongs to the CarA family
CYA_RS00950	COG2197	response regulator
CYA_RS00960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CYA_RS00975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CYA_RS00975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYA_RS00980	COG0322	excinuclease ABC activity
CYA_RS00990	COG0515	serine threonine protein kinase
CYA_RS00995	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYA_RS01000	COG0631	protein serine/threonine phosphatase activity
CYA_RS01005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYA_RS01010	COG3937	granule-associated protein
CYA_RS01015	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYA_RS01020	COG1413	lyase activity
CYA_RS01025	COG1413	lyase activity
CYA_RS01030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CYA_RS01045	COG0159	tryptophan synthase activity
CYA_RS01085	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CYA_RS01100	COG3000	fatty acid hydroxylase
CYA_RS01100	COG0300	oxidoreductase activity
CYA_RS01115	COG4106	trans-aconitate 2-methyltransferase activity
CYA_RS01120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYA_RS01125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CYA_RS01135	COG0181	hydroxymethylbilane synthase activity
CYA_RS01145	COG1215	transferase activity, transferring glycosyl groups
CYA_RS01150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CYA_RS01155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYA_RS01165	COG0501	Belongs to the peptidase M48B family
CYA_RS01180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CYA_RS01185	COG0785	Cytochrome C biogenesis protein
CYA_RS01190	COG1333	cytochrome c biogenesis protein
CYA_RS01195	COG3706	GGDEF domain
CYA_RS01195	COG4251	negative regulation of phosphorylation
CYA_RS01195	COG2203	Gaf domain
CYA_RS01195	COG5001	Diguanylate cyclase
CYA_RS01200	COG0277	FAD linked oxidase domain protein
CYA_RS01215	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CYA_RS01235	COG0366	Alpha amylase catalytic
CYA_RS01255	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CYA_RS01260	COG0747	negative chemotaxis
CYA_RS01270	COG0297	glycogen (starch) synthase activity
CYA_RS01290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CYA_RS01295	COG0242	peptide deformylase activity
CYA_RS01315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_RS01320	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYA_RS01325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CYA_RS01330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CYA_RS01335	COG0351	phosphomethylpyrimidine kinase
CYA_RS01345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CYA_RS01355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYA_RS01360	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CYA_RS01380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYA_RS01385	COG0445	tRNA wobble uridine modification
CYA_RS01390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYA_RS01395	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYA_RS01400	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CYA_RS01405	COG2094	Belongs to the DNA glycosylase MPG family
CYA_RS01420	COG0415	Belongs to the DNA photolyase family
CYA_RS01425	COG0776	regulation of translation
CYA_RS01445	COG0072	phenylalanine-tRNA ligase activity
CYA_RS01450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CYA_RS01455	COG1132	(ABC) transporter
CYA_RS01470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_RS01480	COG0126	phosphoglycerate kinase activity
CYA_RS01485	COG0493	'glutamate synthase
CYA_RS01485	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYA_RS01490	COG1562	ergosterol biosynthetic process
CYA_RS01500	COG1111	helicase
CYA_RS01500	COG1205	dead DEAH box helicase
CYA_RS01515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYA_RS01525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYA_RS01555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYA_RS01555	COG2022	thiamine diphosphate biosynthetic process
CYA_RS01565	COG0459	protein refolding
CYA_RS01570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYA_RS01580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CYA_RS01585	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CYA_RS01590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CYA_RS01600	COG0133	tryptophan synthase activity
CYA_RS01620	COG0443	Heat shock 70 kDa protein
CYA_RS01630	COG0561	phosphatase activity
CYA_RS01635	COG0210	DNA helicase
CYA_RS01635	COG0210	DNA helicase
CYA_RS01640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYA_RS01650	COG0431	NADPH-dependent FMN reductase
CYA_RS01680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYA_RS01685	COG0424	maF-like protein
CYA_RS01690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYA_RS01695	COG1254	Belongs to the acylphosphatase family
CYA_RS01700	COG1254	Belongs to the acylphosphatase family
CYA_RS01715	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYA_RS01715	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYA_RS01730	COG1077	Cell shape determining protein MreB Mrl
CYA_RS01745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_RS01755	COG0515	serine threonine protein kinase
CYA_RS01760	COG0483	inositol monophosphate 1-phosphatase activity
CYA_RS01765	COG1216	Glycosyl transferase, family 2
CYA_RS01770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CYA_RS01790	COG2912	Transglutaminase-like superfamily
CYA_RS01820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYA_RS01820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYA_RS01825	COG0166	Belongs to the GPI family
CYA_RS01830	COG3429	Glucose-6-phosphate dehydrogenase subunit
CYA_RS01830	COG3409	Peptidoglycan-binding domain 1 protein
CYA_RS01835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYA_RS01845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYA_RS01850	COG0656	L-ascorbic acid biosynthetic process
CYA_RS01875	COG0149	triose-phosphate isomerase activity
CYA_RS01890	COG0501	Belongs to the peptidase M48B family
CYA_RS01895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYA_RS01900	COG1132	(ABC) transporter
CYA_RS01910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CYA_RS01915	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CYA_RS01925	COG5398	heme oxygenase
CYA_RS01930	COG0085	RNA polymerase activity
CYA_RS01935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYA_RS01940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYA_RS01945	COG1573	uracil-dna glycosylase
CYA_RS01950	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CYA_RS01950	COG0351	phosphomethylpyrimidine kinase
CYA_RS01950	COG0352	thiamine-phosphate diphosphorylase activity
CYA_RS01955	COG5322	oxidoreductase activity
CYA_RS01960	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CYA_RS01980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CYA_RS01990	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CYA_RS01995	COG1959	2 iron, 2 sulfur cluster binding
CYA_RS02000	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CYA_RS02010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYA_RS02020	COG0475	glutathione-regulated potassium exporter activity
CYA_RS02025	COG1716	ATPase activity
CYA_RS02025	COG5001	Diguanylate cyclase
CYA_RS02110	COG1192	Involved in chromosome partitioning
CYA_RS02140	COG0779	Required for maturation of 30S ribosomal subunits
CYA_RS02145	COG0195	Participates in both transcription termination and antitermination
CYA_RS02150	COG0163	prenyltransferase activity
CYA_RS02160	COG2082	Precorrin-8x methylmutase
CYA_RS02180	COG1489	DNA binding
CYA_RS02185	COG0708	Exodeoxyribonuclease III
CYA_RS02190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYA_RS02195	COG4208	sulfate ABC transporter
CYA_RS02200	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CYA_RS02205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CYA_RS02210	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CYA_RS02220	COG1012	belongs to the aldehyde dehydrogenase family
CYA_RS02220	COG1454	alcohol dehydrogenase
CYA_RS02230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CYA_RS02245	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CYA_RS02250	COG0745	RESPONSE REGULATOR receiver
CYA_RS02255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CYA_RS02260	COG0596	Alpha beta hydrolase
CYA_RS02265	COG0509	glycine decarboxylation via glycine cleavage system
CYA_RS02280	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYA_RS02285	COG1230	cation diffusion facilitator family transporter
CYA_RS02300	COG0632	four-way junction helicase activity
CYA_RS02305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CYA_RS02310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_RS02325	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CYA_RS02345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYA_RS02350	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CYA_RS02370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYA_RS02370	COG0140	phosphoribosyl-ATP diphosphatase activity
CYA_RS02375	COG1649	PFAM Uncharacterised BCR, COG1649
CYA_RS02375	COG0726	polysaccharide deacetylase
CYA_RS02405	COG0724	RNA recognition motif
CYA_RS02410	COG0525	valine-tRNA ligase activity
CYA_RS02415	COG0789	Transcriptional regulator
CYA_RS02425	COG0575	Belongs to the CDS family
CYA_RS02430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CYA_RS02435	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_RS02480	COG1587	Uroporphyrinogen-III synthase
CYA_RS02490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYA_RS02490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYA_RS02495	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYA_RS02505	COG2226	methyltransferase
CYA_RS02510	COG0010	Belongs to the arginase family
CYA_RS02520	COG0450	alkyl hydroperoxide reductase
CYA_RS02540	COG1494	fructose-1,6-bisphosphatase
CYA_RS02545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CYA_RS02555	COG1217	gtp-binding protein TYPA
CYA_RS02565	COG1058	Belongs to the CinA family
CYA_RS02565	COG1546	Belongs to the CinA family
CYA_RS02570	COG0456	acetyltransferase
CYA_RS02590	COG0489	protein tyrosine kinase activity
CYA_RS02600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CYA_RS02615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CYA_RS02620	COG0271	Belongs to the BolA IbaG family
CYA_RS02625	COG1950	PFAM Membrane protein of
CYA_RS02630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CYA_RS02650	COG0237	dephospho-CoA kinase activity
CYA_RS02655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYA_RS02665	COG1606	tRNA processing
CYA_RS02695	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CYA_RS02700	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CYA_RS02710	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYA_RS02720	COG0799	negative regulation of ribosome biogenesis
CYA_RS02730	COG0481	GTPase activity
CYA_RS02740	COG0752	glycyl-tRNA synthetase alpha subunit
CYA_RS02765	COG0436	Aminotransferase
CYA_RS02775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CYA_RS02800	COG1191	sigma factor activity
CYA_RS02810	COG3328	transposase activity
CYA_RS02820	COG0832	Belongs to the urease beta subunit family
CYA_RS02820	COG0831	urea catabolic process
CYA_RS02825	COG0831	urea catabolic process
CYA_RS02825	COG0832	Belongs to the urease beta subunit family
CYA_RS02830	COG0804	urea catabolic process
CYA_RS02835	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CYA_RS02840	COG0830	nickel cation binding
CYA_RS02845	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CYA_RS02850	COG0829	nickel cation binding
CYA_RS02880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYA_RS02885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYA_RS02890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYA_RS02890	COG1116	anion transmembrane transporter activity
CYA_RS02895	COG1116	anion transmembrane transporter activity
CYA_RS02905	COG0243	molybdopterin cofactor binding
CYA_RS02920	COG0151	Belongs to the GarS family
CYA_RS02930	COG1078	dGTPase activity
CYA_RS02940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CYA_RS02945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYA_RS02950	COG0778	Nitroreductase
CYA_RS02960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYA_RS02970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CYA_RS02980	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CYA_RS02990	COG2205	protein histidine kinase activity
CYA_RS02995	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYA_RS03005	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_RS03010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYA_RS03035	COG0784	Response regulator, receiver
CYA_RS03040	COG0047	phosphoribosylformylglycinamidine synthase activity
CYA_RS03045	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYA_RS03055	COG2045	Belongs to the ComB family
CYA_RS03065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CYA_RS03085	COG0542	response to heat
CYA_RS03090	COG0740	serine-type endopeptidase activity
CYA_RS03100	COG0740	serine-type endopeptidase activity
CYA_RS03145	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYA_RS03160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYA_RS03165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYA_RS03170	COG2239	Acts as a magnesium transporter
CYA_RS03180	COG1285	pathogenesis
CYA_RS03185	COG2119	membrane
CYA_RS03190	COG0792	nuclease activity
CYA_RS03200	COG3688	RNA-binding protein containing a PIN domain
CYA_RS03210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CYA_RS03215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYA_RS03220	COG0765	amino acid transport
CYA_RS03230	COG1053	succinate dehydrogenase
CYA_RS03235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CYA_RS03245	COG1160	GTP binding
CYA_RS03250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYA_RS03275	COG3956	TIGRFAM MazG family protein
CYA_RS03295	COG0617	tRNA 3'-terminal CCA addition
CYA_RS03295	COG0517	IMP dehydrogenase activity
CYA_RS03295	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CYA_RS03300	COG0233	cytoplasmic translational termination
CYA_RS03305	COG2010	Cytochrome c
CYA_RS03315	COG2119	membrane
CYA_RS03325	COG0792	nuclease activity
CYA_RS03330	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CYA_RS03335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CYA_RS03340	COG0137	argininosuccinate synthase activity
CYA_RS03355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYA_RS03365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CYA_RS03370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYA_RS03375	COG0419	ATPase involved in DNA repair
CYA_RS03400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CYA_RS03410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CYA_RS03470	COG0564	pseudouridine synthase activity
CYA_RS03475	COG0574	Belongs to the PEP-utilizing enzyme family
CYA_RS03475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYA_RS03485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_RS03490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CYA_RS03500	COG0649	NAD binding
CYA_RS03510	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYA_RS03525	COG0829	nickel cation binding
CYA_RS03540	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CYA_RS03555	COG0552	protein localization to endoplasmic reticulum
CYA_RS03560	COG0788	formyltetrahydrofolate deformylase activity
CYA_RS03565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYA_RS03570	COG0653	protein targeting
CYA_RS03585	COG0826	peptidase U32
CYA_RS03595	COG2062	phosphohistidine phosphatase, SixA
CYA_RS03600	COG3118	belongs to the thioredoxin family
CYA_RS03610	COG0135	phosphoribosylanthranilate isomerase activity
CYA_RS03620	COG1187	pseudouridine synthase activity
CYA_RS03630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CYA_RS03645	COG0415	Belongs to the DNA photolyase family
CYA_RS03655	COG1305	Transglutaminase-like
CYA_RS03660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CYA_RS03665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYA_RS03675	COG0443	Heat shock 70 kDa protein
CYA_RS03680	COG0484	heat shock protein binding
CYA_RS03685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYA_RS03685	COG0425	Belongs to the sulfur carrier protein TusA family
CYA_RS03690	COG1162	GTPase activity
CYA_RS03710	COG2205	protein histidine kinase activity
CYA_RS03725	COG0328	RNA-DNA hybrid ribonuclease activity
CYA_RS03730	COG0857	belongs to the CobB CobQ family
CYA_RS03735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CYA_RS03740	COG0569	domain protein
CYA_RS03745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CYA_RS03750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYA_RS03755	COG0571	ribonuclease III activity
CYA_RS03810	COG0436	Aminotransferase
CYA_RS03825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYA_RS03835	COG1530	ribonuclease E activity
CYA_RS03840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYA_RS03920	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CYA_RS03950	COG0024	Methionine aminopeptidase
CYA_RS03955	COG0038	chloride channel
CYA_RS03960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYA_RS03965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYA_RS03970	COG4447	cellulose binding
CYA_RS03975	COG1773	rubredoxin
CYA_RS03980	COG5001	Diguanylate cyclase
CYA_RS03980	COG1716	ATPase activity
CYA_RS03985	COG0439	Biotin carboxylase
CYA_RS04000	COG0484	heat shock protein binding
CYA_RS04015	COG0010	Belongs to the arginase family
CYA_RS04020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CYA_RS04025	COG1799	cell septum assembly
CYA_RS04030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CYA_RS04035	COG1252	NADH dehydrogenase
CYA_RS04055	COG0408	coproporphyrinogen oxidase activity
CYA_RS04060	COG0400	carboxylic ester hydrolase activity
CYA_RS04095	COG1337	RAMP superfamily
CYA_RS04130	COG1468	defense response to virus
CYA_RS04130	COG1518	maintenance of DNA repeat elements
CYA_RS04150	COG1116	anion transmembrane transporter activity
CYA_RS04155	COG1116	anion transmembrane transporter activity
CYA_RS04155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYA_RS04160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYA_RS04165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYA_RS04175	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYA_RS04200	COG1366	Belongs to the anti-sigma-factor antagonist family
CYA_RS04215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYA_RS04230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CYA_RS04235	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CYA_RS04240	COG1660	Displays ATPase and GTPase activities
CYA_RS04245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYA_RS04250	COG0750	zinc metalloprotease
CYA_RS04255	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CYA_RS04260	COG4956	integral membrane protein (PIN domain superfamily)
CYA_RS04265	COG2205	protein histidine kinase activity
CYA_RS04265	COG3437	response regulator, receiver
CYA_RS04265	COG3850	Histidine kinase
CYA_RS04265	COG4999	Histidine kinase
CYA_RS04270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYA_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
CYA_RS04280	COG0616	signal peptide processing
CYA_RS04305	COG0268	Binds directly to 16S ribosomal RNA
CYA_RS04330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CYA_RS04365	COG1666	GTP binding
CYA_RS04370	COG0300	oxidoreductase activity
CYA_RS04375	COG1716	ATPase activity
CYA_RS04375	COG5001	Diguanylate cyclase
CYA_RS04385	COG0768	penicillin binding
CYA_RS04390	COG0776	regulation of translation
CYA_RS04395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYA_RS04410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYA_RS04420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CYA_RS04425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CYA_RS04430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CYA_RS04440	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CYA_RS04445	COG4178	(ABC) transporter
CYA_RS04450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYA_RS04485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CYA_RS04490	COG0772	Belongs to the SEDS family
CYA_RS04510	COG0596	Alpha beta hydrolase
CYA_RS04515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYA_RS04520	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CYA_RS04530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CYA_RS04540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYA_RS04545	COG0737	Belongs to the 5'-nucleotidase family
CYA_RS04550	COG4399	Belongs to the UPF0754 family
CYA_RS04565	COG0667	Aldo Keto reductase
CYA_RS04575	COG0745	RESPONSE REGULATOR receiver
CYA_RS04600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CYA_RS04605	COG0583	DNA-binding transcription factor activity
CYA_RS04610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYA_RS04635	COG0371	Dehydrogenase
CYA_RS04685	COG1982	Orn Lys Arg decarboxylase major
CYA_RS04690	COG1253	flavin adenine dinucleotide binding
CYA_RS04700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYA_RS04705	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CYA_RS04750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYA_RS04800	COG0672	)-iron permease
CYA_RS04805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYA_RS04820	COG3854	ATPases associated with a variety of cellular activities
CYA_RS04825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYA_RS04830	COG0745	RESPONSE REGULATOR receiver
CYA_RS04835	COG0617	tRNA 3'-terminal CCA addition
CYA_RS04840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYA_RS04870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CYA_RS04880	COG2308	Evidence 4 Homologs of previously reported genes of
CYA_RS04910	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYA_RS04915	COG1090	epimerase
CYA_RS04920	COG1131	(ABC) transporter
CYA_RS04925	COG0438	transferase activity, transferring glycosyl groups
CYA_RS04935	COG2226	methyltransferase
CYA_RS04940	COG2022	thiamine diphosphate biosynthetic process
CYA_RS04955	COG0737	Belongs to the 5'-nucleotidase family
CYA_RS04975	COG0105	UTP biosynthetic process
CYA_RS04980	COG1116	anion transmembrane transporter activity
CYA_RS05000	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CYA_RS05005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CYA_RS05010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CYA_RS05015	COG0768	penicillin binding
CYA_RS05025	COG1480	7TM receptor with intracellular HD hydrolase
CYA_RS05035	COG2091	lysine biosynthetic process via aminoadipic acid
CYA_RS05040	COG1316	TRANSCRIPTIONal
CYA_RS05045	COG0326	Molecular chaperone. Has ATPase activity
CYA_RS05050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CYA_RS05060	COG3046	protein related to deoxyribodipyrimidine photolyase
CYA_RS05065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CYA_RS05100	COG0802	atpase or kinase
CYA_RS05105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CYA_RS05110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CYA_RS05115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYA_RS05120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CYA_RS05120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYA_RS05125	COG2135	peptidase activity
CYA_RS05130	COG0366	Alpha amylase catalytic
CYA_RS05145	COG0460	homoserine dehydrogenase
CYA_RS05150	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CYA_RS05155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYA_RS05185	COG4206	TonB-dependent receptor
CYA_RS05215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CYA_RS05225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYA_RS05240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CYA_RS05240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CYA_RS05245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CYA_RS05250	COG0175	sulfate reduction
CYA_RS05260	COG0640	Transcriptional regulator
CYA_RS05290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CYA_RS05295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYA_RS05305	COG0484	heat shock protein binding
CYA_RS05310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CYA_RS05330	COG0702	epimerase
CYA_RS05355	COG0354	folic acid binding
CYA_RS05375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CYA_RS05390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CYA_RS05400	COG0723	plastoquinol--plastocyanin reductase activity
CYA_RS05405	COG0438	transferase activity, transferring glycosyl groups
CYA_RS05420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CYA_RS05425	COG0024	Methionine aminopeptidase
CYA_RS05430	COG0563	adenylate kinase activity
CYA_RS05435	COG0201	protein transport
CYA_RS05440	COG0200	Binds to the 23S rRNA
CYA_RS05445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CYA_RS05450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CYA_RS05455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CYA_RS05460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CYA_RS05465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CYA_RS05470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CYA_RS05475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CYA_RS05480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CYA_RS05485	COG0255	Belongs to the universal ribosomal protein uL29 family
CYA_RS05490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CYA_RS05495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CYA_RS05500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CYA_RS05505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CYA_RS05510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CYA_RS05515	COG0089	rRNA binding
CYA_RS05520	COG0088	Forms part of the polypeptide exit tunnel
CYA_RS05525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CYA_RS05565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CYA_RS05580	COG1797	cobyrinic acid a,c-diamide synthase activity
CYA_RS05595	COG0740	serine-type endopeptidase activity
CYA_RS05600	COG1850	ribulose-bisphosphate carboxylase activity
CYA_RS05610	COG4451	ribulose bisphosphate carboxylase, small
CYA_RS05615	COG1836	PFAM Integral membrane protein DUF92
CYA_RS05630	COG1702	phosphate starvation-inducible protein PhoH
CYA_RS05635	COG1011	Hydrolase
CYA_RS05640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYA_RS05650	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CYA_RS05655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYA_RS05675	COG1137	ATPase activity
CYA_RS05680	COG0469	pyruvate kinase activity
CYA_RS05695	COG0557	exoribonuclease II activity
CYA_RS05700	COG0745	RESPONSE REGULATOR receiver
CYA_RS05705	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
CYA_RS05710	COG0436	Aminotransferase
CYA_RS05715	COG1160	GTP binding
CYA_RS05720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CYA_RS05730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CYA_RS05735	COG2385	sporulation resulting in formation of a cellular spore
CYA_RS05735	COG2247	cell wall binding repeat
CYA_RS05755	COG0714	Associated with various cellular activities
CYA_RS05760	COG1959	2 iron, 2 sulfur cluster binding
CYA_RS05765	COG0539	negative regulation of cytoplasmic translation
CYA_RS05770	COG2911	Protein conserved in bacteria
CYA_RS05770	COG1361	Conserved repeat domain
CYA_RS05770	COG3266	domain, Protein
CYA_RS05775	COG3932	Exopolysaccharide synthesis, ExoD
CYA_RS05790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CYA_RS05795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CYA_RS05810	COG4372	Transposase
CYA_RS05825	COG0544	peptidyl-prolyl cis-trans isomerase activity
CYA_RS05835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYA_RS05845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYA_RS05850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CYA_RS05855	COG0346	lactoylglutathione lyase activity
CYA_RS05875	COG4948	Mandelate Racemase Muconate Lactonizing
CYA_RS05880	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CYA_RS05900	COG0193	aminoacyl-tRNA hydrolase activity
CYA_RS05915	COG0495	leucyl-tRNA aminoacylation
CYA_RS05920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CYA_RS05925	COG0572	uridine kinase
CYA_RS05930	COG0363	glucosamine-6-phosphate deaminase activity
CYA_RS05950	COG0850	regulation of cytokinetic process
CYA_RS05955	COG2894	cell division
CYA_RS05960	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CYA_RS05975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CYA_RS05985	COG0511	ligase activity, forming carbon-carbon bonds
CYA_RS05990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CYA_RS05995	COG1214	PFAM Peptidase M22, glycoprotease
CYA_RS06025	COG0805	protein transport
CYA_RS06030	COG0765	amino acid transport
CYA_RS06035	COG4597	amino acid ABC transporter
CYA_RS06040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYA_RS06045	COG1126	abc transporter atp-binding protein
CYA_RS06065	COG0159	tryptophan synthase activity
CYA_RS06090	COG0602	queuosine metabolic process
CYA_RS06110	COG1040	competence protein
CYA_RS06115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CYA_RS06120	COG0049	tRNA binding
CYA_RS06125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYA_RS06130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYA_RS06135	COG0051	transcription antitermination factor activity, RNA binding
CYA_RS06140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CYA_RS06160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYA_RS06165	COG0805	protein transport
CYA_RS06215	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CYA_RS06220	COG1429	ligase activity, forming nitrogen-metal bonds
CYA_RS06245	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYA_RS06260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CYA_RS06280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYA_RS06310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYA_RS06315	COG0697	spore germination
CYA_RS06320	COG0180	Tryptophanyl-tRNA synthetase
CYA_RS06330	COG0457	Tetratricopeptide repeat
CYA_RS06335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYA_RS06360	COG5002	protein histidine kinase activity
CYA_RS06385	COG0285	dihydrofolate synthase activity
CYA_RS06390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYA_RS06420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYA_RS06425	COG0492	ferredoxin-NADP+ reductase activity
CYA_RS06430	COG0174	glutamine synthetase
CYA_RS06440	COG1028	Short-chain dehydrogenase reductase Sdr
CYA_RS06445	COG0589	response to stress
CYA_RS06445	COG0475	glutathione-regulated potassium exporter activity
CYA_RS06455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CYA_RS06460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CYA_RS06465	COG0395	ABC-type sugar transport system, permease component
CYA_RS06470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CYA_RS06475	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYA_RS06525	COG0735	belongs to the Fur family
CYA_RS06535	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CYA_RS06540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYA_RS06575	COG0745	RESPONSE REGULATOR receiver
CYA_RS06580	COG1381	Involved in DNA repair and RecF pathway recombination
CYA_RS06585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CYA_RS06600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYA_RS06625	COG0723	plastoquinol--plastocyanin reductase activity
CYA_RS06630	COG0739	heme binding
CYA_RS06640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CYA_RS06645	COG0459	protein refolding
CYA_RS06655	COG0516	GMP reductase activity
CYA_RS06665	COG3659	wide pore channel activity
CYA_RS06670	COG3659	wide pore channel activity
CYA_RS06680	COG0659	secondary active sulfate transmembrane transporter activity
CYA_RS06685	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYA_RS06695	COG1929	Belongs to the glycerate kinase type-1 family
CYA_RS06705	COG0154	amidase activity
CYA_RS06730	COG0633	Ferredoxin
CYA_RS06795	COG3842	ATPase activity
CYA_RS06800	COG0071	Belongs to the small heat shock protein (HSP20) family
CYA_RS06810	COG1049	propionate catabolic process, 2-methylcitrate cycle
CYA_RS06815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CYA_RS06820	COG0254	rRNA binding
CYA_RS06825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CYA_RS06830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CYA_RS06835	COG0101	tRNA pseudouridine synthase activity
CYA_RS06840	COG0203	ribosomal protein L17
CYA_RS06845	COG0202	RNA polymerase activity
CYA_RS06850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CYA_RS06855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CYA_RS06860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CYA_RS06875	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CYA_RS06880	COG0673	inositol 2-dehydrogenase activity
CYA_RS06885	COG0730	response to heat
CYA_RS06890	COG0077	Prephenate dehydratase
CYA_RS06890	COG1605	Chorismate mutase
CYA_RS06900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CYA_RS06905	COG0616	signal peptide processing
CYA_RS06920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CYA_RS06925	COG0473	3-isopropylmalate dehydrogenase activity
CYA_RS06955	COG0717	Belongs to the dCTP deaminase family
CYA_RS06960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CYA_RS06970	COG0667	Aldo Keto reductase
CYA_RS06980	COG0504	CTP synthase activity
CYA_RS07000	COG1007	ATP synthesis coupled electron transport
CYA_RS07050	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CYA_RS07060	COG0431	NADPH-dependent FMN reductase
CYA_RS07075	COG0191	fructose-bisphosphate aldolase activity
CYA_RS07105	COG0534	Mate efflux family protein
CYA_RS07110	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CYA_RS07115	COG0004	ammonium transporteR
CYA_RS07120	COG0347	Belongs to the P(II) protein family
CYA_RS07140	COG1845	cytochrome c oxidase, subunit III
CYA_RS07145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYA_RS07155	COG1612	heme a metabolic process
CYA_RS07160	COG0109	protoheme IX farnesyltransferase activity
CYA_RS07170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYA_RS07175	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CYA_RS07190	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CYA_RS07195	COG1372	Participates in initiation and elongation during chromosome replication
CYA_RS07195	COG0187	DNA topoisomerase II activity
CYA_RS07200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CYA_RS07205	COG0330	HflC and HflK could
CYA_RS07225	COG0739	heme binding
CYA_RS07235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CYA_RS07245	COG0529	Catalyzes the synthesis of activated sulfate
CYA_RS07250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYA_RS07275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYA_RS07280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CYA_RS07285	COG0789	Transcriptional regulator
CYA_RS07290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYA_RS07300	COG1127	ABC transporter
CYA_RS07305	COG0861	Integral membrane protein TerC family
CYA_RS07310	COG1691	(AIR) carboxylase
CYA_RS07320	COG0305	Participates in initiation and elongation during chromosome replication
CYA_RS07320	COG1372	Participates in initiation and elongation during chromosome replication
CYA_RS07325	COG0359	binds to the 23S rRNA
CYA_RS07335	COG0573	inorganic phosphate transmembrane transporter activity
CYA_RS07340	COG0581	inorganic phosphate transmembrane transporter activity
CYA_RS07345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CYA_RS07360	COG2046	Belongs to the sulfate adenylyltransferase family
CYA_RS07375	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYA_RS07380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYA_RS07395	COG0402	S-adenosylhomocysteine deaminase activity
CYA_RS07410	COG0352	thiamine-phosphate diphosphorylase activity
CYA_RS07415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_RS07430	COG0537	adenosine 5'-monophosphoramidase activity
CYA_RS07435	COG2082	Precorrin-8x methylmutase
CYA_RS07445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYA_RS07445	COG0426	domain, Protein
CYA_RS07450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CYA_RS07460	COG1079	Belongs to the binding-protein-dependent transport system permease family
CYA_RS07465	COG4603	Belongs to the binding-protein-dependent transport system permease family
CYA_RS07470	COG3845	ABC transporter
CYA_RS07490	COG0402	S-adenosylhomocysteine deaminase activity
CYA_RS07500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CYA_RS07520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYA_RS07525	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_RS07545	COG0613	PHP domain protein
CYA_RS07550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYA_RS07565	COG3794	PFAM blue (type 1) copper domain protein
CYA_RS07595	COG1122	ATPase activity
CYA_RS07600	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CYA_RS07605	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CYA_RS07610	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CYA_RS07615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CYA_RS07615	COG4451	ribulose bisphosphate carboxylase, small
CYA_RS07620	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CYA_RS07625	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CYA_RS07640	COG0335	large ribosomal subunit rRNA binding
CYA_RS07645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYA_RS07650	COG0577	efflux transmembrane transporter activity
CYA_RS07650	COG1136	(ABC) transporter
CYA_RS07655	COG0083	homoserine kinase activity
CYA_RS07660	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CYA_RS07665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYA_RS07675	COG0739	heme binding
CYA_RS07680	COG1122	ATPase activity
CYA_RS07690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYA_RS07695	COG0713	ATP synthesis coupled electron transport
CYA_RS07710	COG0095	Lipoate-protein ligase
CYA_RS07725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CYA_RS07735	COG0052	Belongs to the universal ribosomal protein uS2 family
CYA_RS07740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CYA_RS07745	COG0402	S-adenosylhomocysteine deaminase activity
CYA_RS07750	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CYA_RS07770	COG0592	DNA-directed DNA polymerase activity
CYA_RS07780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYA_RS07785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CYA_RS07790	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CYA_RS07800	COG1234	tRNA 3'-trailer cleavage
CYA_RS07805	COG0316	Belongs to the HesB IscA family
CYA_RS07810	COG5002	protein histidine kinase activity
CYA_RS07820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYA_RS07825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYA_RS07825	COG0426	domain, Protein
CYA_RS07845	COG0406	alpha-ribazole phosphatase activity
CYA_RS07850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CYA_RS07855	COG1295	ribonuclease BN
CYA_RS07855	COG1959	2 iron, 2 sulfur cluster binding
CYA_RS07860	COG0009	L-threonylcarbamoyladenylate synthase
CYA_RS07865	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CYA_RS07875	COG0523	cobalamin synthesis protein
CYA_RS07890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CYA_RS07890	COG0519	Catalyzes the synthesis of GMP from XMP
CYA_RS07900	COG0357	Ribosomal RNA small subunit methyltransferase G
CYA_RS07905	COG0724	RNA recognition motif
CYA_RS07910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYA_RS07915	COG1121	(ABC) transporter
CYA_RS07920	COG0803	Belongs to the bacterial solute-binding protein 9 family
CYA_RS07925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CYA_RS07930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CYA_RS07935	COG0628	permease
CYA_RS07950	COG2010	Cytochrome c
CYA_RS07955	COG2010	Cytochrome c
CYA_RS07965	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CYA_RS07970	COG2003	Belongs to the UPF0758 family
CYA_RS07975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CYA_RS07985	COG2239	Acts as a magnesium transporter
CYA_RS07990	COG0644	oxidoreductase
CYA_RS07990	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CYA_RS08005	COG0129	dihydroxy-acid dehydratase activity
CYA_RS08010	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CYA_RS08015	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CYA_RS08025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CYA_RS08035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYA_RS08040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYA_RS08055	COG0006	proline dipeptidase activity
CYA_RS08085	COG0284	orotidine-5'-phosphate decarboxylase activity
CYA_RS08110	COG0798	PFAM Bile acid sodium symporter
CYA_RS08125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYA_RS08135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYA_RS08150	COG3118	belongs to the thioredoxin family
CYA_RS08155	COG0321	lipoyl(octanoyl) transferase activity
CYA_RS08170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYA_RS08175	COG0540	Belongs to the ATCase OTCase family
CYA_RS08180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CYA_RS08185	COG0573	inorganic phosphate transmembrane transporter activity
CYA_RS08190	COG0581	inorganic phosphate transmembrane transporter activity
CYA_RS08195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CYA_RS08205	COG0701	Predicted permease
CYA_RS08210	COG0372	Belongs to the citrate synthase family
CYA_RS08215	COG3688	RNA-binding protein containing a PIN domain
CYA_RS08220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYA_RS08240	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYA_RS08250	COG0527	aspartate kinase activity
CYA_RS08260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYA_RS08290	COG0651	ATP synthesis coupled electron transport
CYA_RS08295	COG1006	Multisubunit Na H antiporter MnhC subunit
CYA_RS08305	COG1846	Transcriptional regulator
CYA_RS08330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CYA_RS08335	COG1271	oxidase subunit
CYA_RS08340	COG1294	oxidase, subunit
CYA_RS08345	COG0668	transmembrane transport
CYA_RS08350	COG0456	acetyltransferase
CYA_RS08360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CYA_RS08375	COG0336	Belongs to the RNA methyltransferase TrmD family
CYA_RS08385	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CYA_RS08390	COG0250	Participates in transcription elongation, termination and antitermination
CYA_RS08395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CYA_RS08400	COG0081	regulation of translation
CYA_RS08405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CYA_RS08410	COG0222	ribosome binding
CYA_RS08415	COG0706	membrane insertase activity
CYA_RS08430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYA_RS08465	COG0793	Belongs to the peptidase S41A family
CYA_RS08470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYA_RS08475	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYA_RS08480	COG0473	3-isopropylmalate dehydrogenase activity
CYA_RS08485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYA_RS08505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CYA_RS08540	COG1615	UPF0182 protein
CYA_RS08550	COG2255	four-way junction helicase activity
CYA_RS08555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYA_RS08555	COG0237	dephospho-CoA kinase activity
CYA_RS08585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYA_RS08590	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYA_RS08600	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CYA_RS08610	COG1104	cysteine desulfurase activity
CYA_RS08615	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
CYA_RS08620	COG0535	radical SAM domain protein
CYA_RS08620	COG1433	Dinitrogenase iron-molybdenum cofactor
CYA_RS08630	COG0783	Belongs to the Dps family
CYA_RS08645	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYA_RS08650	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYA_RS08675	COG0633	Ferredoxin
CYA_RS08690	COG3585	molybdate ion transport
CYA_RS08695	COG0725	ABC transporter, periplasmic molybdate-binding protein
CYA_RS08715	COG1615	UPF0182 protein
CYA_RS08725	COG2255	four-way junction helicase activity
CYA_RS08730	COG0237	dephospho-CoA kinase activity
CYA_RS08730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYA_RS08755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYA_RS08760	COG1233	COG1233 Phytoene dehydrogenase and related
CYA_RS08765	COG1176	ABC-type spermidine putrescine transport system, permease component I
CYA_RS08770	COG3842	ATPase activity
CYA_RS08780	COG0233	cytoplasmic translational termination
CYA_RS08785	COG0617	tRNA 3'-terminal CCA addition
CYA_RS08785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CYA_RS08785	COG0517	IMP dehydrogenase activity
CYA_RS08790	COG4783	chaperone-mediated protein folding
CYA_RS08795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CYA_RS08800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CYA_RS08830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CYA_RS08835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYA_RS08840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYA_RS08850	COG1136	(ABC) transporter
CYA_RS08855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYA_RS08860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYA_RS08865	COG1357	PFAM Pentapeptide repeats (8 copies)
CYA_RS08865	COG0515	serine threonine protein kinase
CYA_RS08880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYA_RS08905	COG0745	RESPONSE REGULATOR receiver
CYA_RS08920	COG0739	heme binding
CYA_RS08925	COG0215	cysteine-tRNA ligase activity
CYA_RS08940	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CYA_RS08960	COG1957	nucleoside hydrolase
CYA_RS08965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYA_RS08970	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CYA_RS08975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CYA_RS08985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYA_RS09020	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_RS09030	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CYA_RS09035	COG1335	isochorismatase
CYA_RS09040	COG3845	ABC transporter
CYA_RS09050	COG0411	ABC transporter
CYA_RS09060	COG0559	Belongs to the binding-protein-dependent transport system permease family
CYA_RS09075	COG1196	nuclear chromosome segregation
CYA_RS09075	COG0739	heme binding
CYA_RS09075	COG0741	lytic transglycosylase activity
CYA_RS09085	COG0484	heat shock protein binding
CYA_RS09125	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYA_RS09150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CYA_RS09160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYA_RS09165	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CYA_RS09175	COG1070	Carbohydrate kinase
CYA_RS09180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYA_RS09215	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CYA_RS09225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYA_RS09240	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYA_RS09245	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYA_RS09255	COG4948	Mandelate Racemase Muconate Lactonizing
CYA_RS09265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CYA_RS09275	COG1459	type II secretion system
CYA_RS09285	COG0033	Phosphoglucomutase
CYA_RS09310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CYA_RS09315	COG1722	exodeoxyribonuclease VII activity
CYA_RS09320	COG1570	exodeoxyribonuclease VII activity
CYA_RS09345	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CYA_RS09350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYA_RS09375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYA_RS09405	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_RS09410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_RS09415	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYA_RS09465	COG3956	TIGRFAM MazG family protein
CYA_RS09490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CYA_RS09500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYA_RS09515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CYA_RS09530	COG0606	chelatase, subunit chli
CYA_RS09535	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYA_RS09555	COG0745	RESPONSE REGULATOR receiver
CYA_RS09580	COG1120	ATPase activity
CYA_RS09585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYA_RS09595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYA_RS09605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYA_RS09610	COG0728	peptidoglycan biosynthetic process
CYA_RS09620	COG1413	lyase activity
CYA_RS09645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CYA_RS09660	COG1136	(ABC) transporter
CYA_RS09665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CYA_RS09675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CYA_RS09680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CYA_RS09695	COG0484	heat shock protein binding
CYA_RS09700	COG4572	Cation transport regulator
CYA_RS09705	COG2234	aminopeptidase activity
CYA_RS09710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYA_RS09715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYA_RS09725	COG0312	modulator of DNA gyrase
CYA_RS09730	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CYA_RS09745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYA_RS09755	COG3781	membrane
CYA_RS09770	COG0297	glycogen (starch) synthase activity
CYA_RS09775	COG1543	Belongs to the glycosyl hydrolase 57 family
CYA_RS09780	COG0028	Belongs to the TPP enzyme family
CYA_RS09820	COG0659	secondary active sulfate transmembrane transporter activity
CYA_RS09840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CYA_RS09845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYA_RS09870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CYA_RS09875	COG1555	photosystem II stabilization
CYA_RS09880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYA_RS09880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYA_RS09910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CYA_RS09920	COG2226	methyltransferase
CYA_RS09935	COG1840	ABC-type Fe3 transport system, periplasmic component
CYA_RS09945	COG1178	ABC-type Fe3 transport system permease component
CYA_RS09950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CYA_RS09955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CYA_RS09960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYA_RS09965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYA_RS09970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYA_RS09975	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYA_RS09980	COG0356	it plays a direct role in the translocation of protons across the membrane
CYA_RS10000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CYA_RS10010	COG0783	Belongs to the Dps family
CYA_RS10015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYA_RS10030	COG0440	acetolactate synthase activity
CYA_RS10045	COG0837	glucose binding
CYA_RS10055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYA_RS10065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYA_RS10075	COG2211	Major facilitator Superfamily
CYA_RS10080	COG1027	Aspartate ammonia-lyase
CYA_RS10090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CYA_RS10095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYA_RS10100	COG2815	serine threonine protein kinase
CYA_RS10100	COG0515	serine threonine protein kinase
CYA_RS10105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYA_RS10110	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYA_RS10120	COG0825	malonyl-CoA metabolic process
CYA_RS10135	COG0784	Response regulator, receiver
CYA_RS10135	COG2198	Histidine kinase
CYA_RS10135	COG0643	Histidine kinase
CYA_RS10140	COG0840	transmembrane signaling receptor activity
CYA_RS10140	COG2203	Gaf domain
CYA_RS10165	COG0784	Response regulator, receiver
CYA_RS10205	COG0517	IMP dehydrogenase activity
CYA_RS10205	COG1994	Peptidase M50
CYA_RS10210	COG0612	Peptidase, M16
CYA_RS10225	COG0454	-acetyltransferase
CYA_RS10240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CYA_RS10250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYA_RS10255	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CYA_RS10260	COG0860	N-Acetylmuramoyl-L-alanine amidase
CYA_RS10285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CYA_RS10300	COG0719	Fe-S assembly protein
CYA_RS10305	COG1970	mechanosensitive ion channel activity
CYA_RS10310	COG0396	ATPase activity
CYA_RS10315	COG0719	Fe-S assembly protein
CYA_RS10345	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CYA_RS10350	COG0066	3-isopropylmalate dehydratase activity
CYA_RS10365	COG0469	pyruvate kinase activity
CYA_RS10400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CYA_RS10410	COG0189	ligase activity
CYA_RS10420	COG1185	polyribonucleotide nucleotidyltransferase activity
CYA_RS10445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYA_RS10450	COG1131	(ABC) transporter
CYA_RS10475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYA_RS10485	COG0517	IMP dehydrogenase activity
CYA_RS10485	COG1125	glycine betaine transport
CYA_RS10495	COG1191	sigma factor activity
CYA_RS10505	COG2720	vancomycin resistance protein
CYA_RS10510	COG2226	methyltransferase
CYA_RS10525	COG0110	maltose O-acetyltransferase activity
CYA_RS10545	COG1881	PFAM PEBP family protein
CYA_RS10565	COG0312	modulator of DNA gyrase
CYA_RS10585	COG0312	modulator of DNA gyrase
CYA_RS10590	COG1573	uracil-dna glycosylase
CYA_RS10595	COG2226	methyltransferase
CYA_RS10605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYA_RS10610	COG0393	Putative heavy-metal-binding
CYA_RS10615	COG0217	transcriptional regulatory protein
CYA_RS10630	COG0515	serine threonine protein kinase
CYA_RS10635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYA_RS10675	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CYA_RS10690	COG0681	Belongs to the peptidase S26 family
CYA_RS10695	COG0142	geranyltranstransferase activity
CYA_RS10700	COG1937	Protein conserved in bacteria
CYA_RS10710	COG0228	four-way junction DNA binding
CYA_RS10725	COG0107	imidazoleglycerol-phosphate synthase activity
CYA_RS10730	COG1218	3'(2'),5'-bisphosphate nucleotidase
CYA_RS10740	COG1842	Phage shock protein A
CYA_RS10760	COG1331	Highly conserved protein containing a thioredoxin domain
CYA_RS10765	COG0456	acetyltransferase
CYA_RS10785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CYA_RS10790	COG0275	rRNA processing
CYA_RS10800	COG2197	response regulator
CYA_RS10830	COG2133	pyrroloquinoline quinone binding
CYA_RS10890	COG0745	RESPONSE REGULATOR receiver
CYA_RS10925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYA_RS10930	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CYA_RS10935	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CYA_RS10940	COG0022	dehydrogenase e1 component
CYA_RS10940	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYA_RS10945	COG0668	transmembrane transport
CYA_RS10950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYA_RS10955	COG0358	DNA primase activity
CYA_RS10960	COG2010	Cytochrome c
CYA_RS10975	COG2372	response to copper ion
CYA_RS10980	COG1357	PFAM Pentapeptide repeats (8 copies)
CYA_RS10980	COG0515	serine threonine protein kinase
CYA_RS10990	COG3437	response regulator, receiver
CYA_RS11000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYA_RS11005	COG0442	prolyl-tRNA aminoacylation
CYA_RS11030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CYA_RS11035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYA_RS11060	COG5002	protein histidine kinase activity
CYA_RS11065	COG4221	oxidoreductase activity
CYA_RS11080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CYA_RS11110	COG0601	transmembrane transport
CYA_RS11125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CYA_RS11130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYA_RS11135	COG0416	fatty acid biosynthetic process
CYA_RS11145	COG0134	indole-3-glycerol-phosphate synthase activity
CYA_RS11160	COG2217	Heavy metal translocating P-type atpase
CYA_RS11165	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CYA_RS11180	COG0009	L-threonylcarbamoyladenylate synthase
CYA_RS11190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYA_RS11195	COG0539	negative regulation of cytoplasmic translation
CYA_RS11205	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CYA_RS11215	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYA_RS11225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CYA_RS11230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CYA_RS11240	COG2099	Precorrin-6x reductase
CYA_RS11245	COG0629	single-stranded DNA binding
CYA_RS11250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYA_RS11265	COG1304	FMN binding
CYA_RS11315	COG0196	riboflavin kinase activity
CYA_RS11320	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CYA_RS11330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYA_RS11335	COG1410	methionine synthase
CYA_RS11335	COG0646	methionine synthase
CYA_RS11340	COG1177	transmembrane transport
CYA_RS11345	COG2267	carboxylic ester hydrolase activity
CYA_RS11360	COG0583	DNA-binding transcription factor activity
CYA_RS11370	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CYA_RS11375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CYA_RS11380	COG0528	UMP kinase activity
CYA_RS11385	COG2119	membrane
CYA_RS11425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYA_RS11430	COG3845	ABC transporter
CYA_RS11445	COG3845	ABC transporter
CYA_RS11450	COG1640	4-alpha-glucanotransferase
CYA_RS11455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CYA_RS11470	COG1846	Transcriptional regulator
CYA_RS11480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CYA_RS11485	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CYA_RS11520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYA_RS11530	COG1575	Belongs to the MenA family. Type 1 subfamily
CYA_RS11550	COG0436	Aminotransferase
CYA_RS11555	COG0673	inositol 2-dehydrogenase activity
CYA_RS11570	COG0783	Belongs to the Dps family
CYA_RS11580	COG0463	Glycosyl transferase, family 2
CYA_RS11585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CYA_RS11610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYA_RS11610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYA_RS11620	COG1725	Transcriptional regulator
CYA_RS11635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CYA_RS11645	COG0559	Belongs to the binding-protein-dependent transport system permease family
CYA_RS11655	COG3119	arylsulfatase activity
CYA_RS11665	COG1028	Short-chain dehydrogenase reductase Sdr
CYA_RS11670	COG0405	Gamma-glutamyltransferase
CYA_RS11675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYA_RS11690	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CYA_RS11705	COG2264	protein methyltransferase activity
CYA_RS11715	COG0124	histidyl-tRNA synthetase
CYA_RS11745	COG0662	Cupin 2, conserved barrel domain protein
CYA_RS11745	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CYA_RS11770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYA_RS11780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYA_RS11790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYA_RS11790	COG0758	DNA mediated transformation
CYA_RS11795	COG2135	peptidase activity
CYA_RS11805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CYA_RS11810	COG1473	amidohydrolase
CYA_RS11835	COG0419	ATPase involved in DNA repair
CYA_RS11845	COG2885	chlorophyll binding
CYA_RS11850	COG2885	chlorophyll binding
CYA_RS11860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYA_RS11870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYA_RS11875	COG1121	(ABC) transporter
CYA_RS11880	COG0803	Belongs to the bacterial solute-binding protein 9 family
CYA_RS11880	COG3443	Belongs to the bacterial solute-binding protein 9 family
CYA_RS11885	COG2166	iron-sulfur cluster assembly
CYA_RS11890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CYA_RS11920	COG3751	2OG-Fe(II) oxygenase superfamily
CYA_RS11995	COG1505	serine-type exopeptidase activity
CYA_RS12000	COG0148	phosphopyruvate hydratase activity
CYA_RS12005	COG0589	response to stress
CYA_RS12010	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
CYA_RS12035	COG0556	nucleotide-excision repair
CYA_RS12045	COG0523	cobalamin synthesis protein
CYA_RS12055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CYA_RS12060	COG5002	protein histidine kinase activity
CYA_RS12100	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CYA_RS12115	COG1193	negative regulation of DNA recombination
CYA_RS12125	COG0832	Belongs to the urease beta subunit family
CYA_RS12145	COG1420	regulation of RNA biosynthetic process
CYA_RS12150	COG0037	tRNA processing
CYA_RS12155	COG2385	sporulation resulting in formation of a cellular spore
CYA_RS12165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CYA_RS12170	COG0251	oxidation-reduction process
CYA_RS12180	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
CYA_RS12190	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CYA_RS12200	COG0716	FMN binding
CYA_RS12215	COG3487	Iron-regulated protein
CYA_RS12230	COG3128	pkhd-type hydroxylase
CYA_RS12235	COG0398	Pfam SNARE associated Golgi protein
CYA_RS12240	COG4106	trans-aconitate 2-methyltransferase activity
CYA_RS12250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CYA_RS12255	COG4243	Vitamin k epoxide reductase
CYA_RS12265	COG0434	BtpA family
CYA_RS12270	COG0167	dihydroorotate dehydrogenase activity
CYA_RS12290	COG0497	DNA recombination
CYA_RS12305	COG0131	Imidazoleglycerol-phosphate dehydratase
CYA_RS12310	COG0514	ATP-dependent DNA helicase (RecQ)
CYA_RS12315	COG1472	Belongs to the glycosyl hydrolase 3 family
CYA_RS12320	COG2010	Cytochrome c
CYA_RS12325	COG0170	dolichyl monophosphate biosynthetic process
CYA_RS12340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYA_RS12370	COG2211	Major facilitator Superfamily
CYA_RS12375	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CYA_RS12385	COG0307	riboflavin synthase, alpha
CYA_RS12390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CYA_RS12400	COG0297	glycogen (starch) synthase activity
CYA_RS12430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYA_RS12430	COG0512	Glutamine amidotransferase of anthranilate synthase
CYA_RS12450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CYA_RS12455	COG5002	protein histidine kinase activity
CYA_RS12470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CYA_RS12470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CYA_RS12480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYA_RS12485	COG0484	heat shock protein binding
CYA_RS12500	COG0039	L-malate dehydrogenase activity
CYA_RS12505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CYA_RS12525	COG0483	inositol monophosphate 1-phosphatase activity
CYA_RS12540	COG1492	cobalamin metabolic process
CYA_RS12545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYA_RS12550	COG1324	tolerance protein
CYA_RS12555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CYA_RS12565	COG0003	Pfam Anion-transporting ATPase
CYA_RS12575	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CYA_RS12585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CYA_RS12615	COG2052	Domain of unknown function (DUF370)
CYA_RS12620	COG0194	GDP metabolic process
CYA_RS12630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CYA_RS12635	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CYA_RS12650	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CYA_RS12655	COG0070	glutamate synthase
CYA_RS12655	COG0069	glutamate synthase activity
CYA_RS12655	COG0067	glutamate synthase
CYA_RS12695	COG2226	methyltransferase
CYA_RS12695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYA_RS12695	COG0596	Alpha beta hydrolase
CYA_RS12705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYA_RS12760	COG0745	RESPONSE REGULATOR receiver
CYA_RS12770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYA_RS12780	COG0018	arginyl-trna synthetase
CYA_RS12785	COG2086	electron transfer activity
CYA_RS12790	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CYA_RS12795	COG0762	integral membrane protein
CYA_RS12820	COG0840	transmembrane signaling receptor activity
CYA_RS12820	COG2203	Gaf domain
CYA_RS12825	COG0784	Response regulator, receiver
CYA_RS12825	COG2198	Histidine kinase
CYA_RS12825	COG0643	Histidine kinase
CYA_RS12825	COG0784	Response regulator, receiver
CYA_RS12825	COG2198	Histidine kinase
CYA_RS12825	COG0643	Histidine kinase
CYA_RS12835	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CYA_RS12870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_RS12880	COG2385	sporulation resulting in formation of a cellular spore
CYA_RS12890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYA_RS12915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYA_RS12920	COG1090	epimerase
CYA_RS12930	COG0113	porphobilinogen synthase activity
CYA_RS12955	COG0483	inositol monophosphate 1-phosphatase activity
CYA_RS12970	COG2205	protein histidine kinase activity
CYA_RS12995	COG2203	Gaf domain
CYA_RS12995	COG5001	Diguanylate cyclase
CYA_RS12995	COG4251	negative regulation of phosphorylation
CYA_RS12995	COG3706	GGDEF domain
CYA_RS13000	COG0084	hydrolase, TatD family'
CYA_RS13015	COG3833	ABC-type maltose transport systems, permease component
CYA_RS13025	COG1175	transmembrane transport
CYA_RS13035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CYA_RS13055	COG0302	gtp cyclohydrolase
CYA_RS13060	COG0300	oxidoreductase activity
CYA_RS13075	COG2890	protein-(glutamine-N5) methyltransferase activity
CYA_RS13080	COG3852	Histidine kinase
CYA_RS13095	COG3118	belongs to the thioredoxin family
CYA_RS13110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYA_RS13135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYA_RS13140	COG0277	FAD linked oxidase domain protein
CYA_RS13145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYA_RS13150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CYA_RS13155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CYA_RS13165	COG0138	bifunctional purine biosynthesis protein purh
CYA_RS13170	COG0811	peptide transport
CYA_RS13175	COG0848	biopolymer transport protein
CYA_RS13180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYA_RS13185	COG0793	Belongs to the peptidase S41A family
CYA_RS13190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CYA_RS13200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYA_RS13200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYA_RS13220	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CYA_RS13220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CYA_RS13230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CYA_RS13240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CYA_RS13255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYA_RS13280	COG0343	queuine tRNA-ribosyltransferase activity
CYA_RS13320	COG0450	alkyl hydroperoxide reductase
CYA_RS13330	COG0668	transmembrane transport
CYA_RS13360	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CYA_RS13375	COG0515	serine threonine protein kinase
CYA_RS13380	COG0589	response to stress
CYA_RS13380	COG0475	glutathione-regulated potassium exporter activity
CYA_RS13385	COG0751	glycine-tRNA ligase activity
CYA_RS13390	COG3001	Fructosamine kinase
CYA_RS13405	COG2205	protein histidine kinase activity
CYA_RS13430	COG2217	Heavy metal translocating P-type atpase
CYA_RS13440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYA_RS13445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYA_RS13450	COG0360	Binds together with S18 to 16S ribosomal RNA
CYA_RS13455	COG0629	single-stranded DNA binding
CYA_RS13460	COG2866	Carboxypeptidase
CYA_RS13465	COG0589	response to stress
CYA_RS13485	COG1131	(ABC) transporter
CYA_RS13490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CYA_RS13495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CYA_RS13505	COG3447	MASE1 domain protein
CYA_RS13505	COG5001	Diguanylate cyclase
CYA_RS13505	COG5002	protein histidine kinase activity
CYA_RS13510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYA_RS13515	COG1129	ABC transporter
CYA_RS13530	COG0772	Belongs to the SEDS family
CYA_RS13535	COG1104	cysteine desulfurase activity
CYA_RS13545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYA_RS13550	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CYA_RS13555	COG0019	diaminopimelate decarboxylase activity
CYA_RS13570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYA_RS13575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CYA_RS13595	COG1196	nuclear chromosome segregation
CYA_RS13600	COG0594	ribonuclease P activity
CYA_RS13650	COG4968	Prepilin-type N-terminal cleavage methylation domain
CYA_RS13680	COG0237	dephospho-CoA kinase activity
CYA_RS13680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYA_RS13685	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CYA_RS13710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CYA_RS13735	COG3263	regulation of cellular component size
CYA_RS13750	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CYA_RS13790	COG5002	protein histidine kinase activity
CYA_RS13790	COG2205	protein histidine kinase activity
CYA_RS13790	COG0784	Response regulator, receiver
CYA_RS13805	COG0484	heat shock protein binding
CYA_RS13815	COG5002	protein histidine kinase activity
CYA_RS13820	COG0642	Histidine kinase
CYA_RS13850	COG5002	protein histidine kinase activity
CYA_RS13855	COG3264	Mechanosensitive ion channel
CYA_RS13855	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division