locus-tag	class	description
KR49_RS00085	COG2135	peptidase activity
KR49_RS00090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR49_RS00095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KR49_RS00100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KR49_RS00130	COG0251	oxidation-reduction process
KR49_RS00140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KR49_RS00145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KR49_RS00150	COG1132	(ABC) transporter
KR49_RS00155	COG0456	acetyltransferase
KR49_RS00170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KR49_RS00175	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KR49_RS00195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KR49_RS00230	COG1845	cytochrome c oxidase, subunit III
KR49_RS00235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KR49_RS00255	COG0530	calcium, potassium:sodium antiporter activity
KR49_RS00260	COG0659	secondary active sulfate transmembrane transporter activity
KR49_RS00265	COG0418	dihydroorotase activity
KR49_RS00290	COG0159	tryptophan synthase activity
KR49_RS00340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_RS00355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KR49_RS00355	COG0140	phosphoribosyl-ATP diphosphatase activity
KR49_RS00370	COG0542	response to heat
KR49_RS00395	COG3794	PFAM blue (type 1) copper domain protein
KR49_RS00405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KR49_RS00410	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KR49_RS00450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KR49_RS00465	COG0339	signal peptide processing
KR49_RS00470	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_RS00475	COG0083	homoserine kinase activity
KR49_RS00480	COG0837	glucose binding
KR49_RS00490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KR49_RS00505	COG0180	Tryptophanyl-tRNA synthetase
KR49_RS00665	COG2124	cytochrome p450
KR49_RS00695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KR49_RS00775	COG4638	Rieske (2fe-2S)
KR49_RS00780	COG1116	anion transmembrane transporter activity
KR49_RS00785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KR49_RS00800	COG0375	protein maturation
KR49_RS00805	COG0010	Belongs to the arginase family
KR49_RS00830	COG2072	flavoprotein involved in K transport
KR49_RS00855	COG2144	transferase activity, transferring acyl groups
KR49_RS00880	COG0405	Gamma-glutamyltransferase
KR49_RS00905	COG1487	ribonuclease activity
KR49_RS00920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KR49_RS00925	COG1611	Belongs to the LOG family
KR49_RS00945	COG2234	aminopeptidase activity
KR49_RS00950	COG2304	oxidoreductase activity
KR49_RS00965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KR49_RS01045	COG4067	protein conserved in archaea
KR49_RS01045	COG0189	ligase activity
KR49_RS01060	COG2197	response regulator
KR49_RS01110	COG0724	RNA recognition motif
KR49_RS01185	COG2197	response regulator
KR49_RS01200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KR49_RS01205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KR49_RS01220	COG1121	(ABC) transporter
KR49_RS01250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KR49_RS01260	COG1119	ATPase activity
KR49_RS01320	COG2226	methyltransferase
KR49_RS01355	COG2059	Chromate
KR49_RS01360	COG1201	RNA secondary structure unwinding
KR49_RS01370	COG1793	dna ligase
KR49_RS01445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KR49_RS01450	COG1175	transmembrane transport
KR49_RS01455	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KR49_RS01475	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KR49_RS01495	COG0740	serine-type endopeptidase activity
KR49_RS01505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR49_RS01510	COG1136	(ABC) transporter
KR49_RS01510	COG0577	efflux transmembrane transporter activity
KR49_RS01515	COG0469	pyruvate kinase activity
KR49_RS01540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KR49_RS01545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KR49_RS01575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KR49_RS01585	COG3842	ATPase activity
KR49_RS01590	COG0395	ABC-type sugar transport system, permease component
KR49_RS01595	COG1175	transmembrane transport
KR49_RS01600	COG1653	transport
KR49_RS01605	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KR49_RS01610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KR49_RS01615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KR49_RS01620	COG0326	Molecular chaperone. Has ATPase activity
KR49_RS01635	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KR49_RS01640	COG0483	inositol monophosphate 1-phosphatase activity
KR49_RS01645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KR49_RS01655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KR49_RS01660	COG0581	inorganic phosphate transmembrane transporter activity
KR49_RS01665	COG0573	inorganic phosphate transmembrane transporter activity
KR49_RS01670	COG0443	Heat shock 70 kDa protein
KR49_RS01675	COG0484	heat shock protein binding
KR49_RS01685	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KR49_RS01690	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KR49_RS01695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KR49_RS01700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KR49_RS01700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KR49_RS01705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KR49_RS01710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KR49_RS01735	COG0166	Belongs to the GPI family
KR49_RS01740	COG0495	leucyl-tRNA aminoacylation
KR49_RS01750	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KR49_RS01755	COG1104	cysteine desulfurase activity
KR49_RS01770	COG2027	D-alanyl-D-alanine carboxypeptidase
KR49_RS01780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KR49_RS01790	COG0322	excinuclease ABC activity
KR49_RS01800	COG3046	protein related to deoxyribodipyrimidine photolyase
KR49_RS01805	COG1981	membrane
KR49_RS01810	COG0613	PHP domain protein
KR49_RS01825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KR49_RS01830	COG1410	methionine synthase
KR49_RS01830	COG0646	methionine synthase
KR49_RS01855	COG2385	sporulation resulting in formation of a cellular spore
KR49_RS01895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KR49_RS01900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KR49_RS01900	COG0072	phenylalanine-tRNA ligase activity
KR49_RS01905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KR49_RS01910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KR49_RS01915	COG0557	exoribonuclease II activity
KR49_RS01925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KR49_RS01960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KR49_RS01965	COG0739	heme binding
KR49_RS01980	COG0450	alkyl hydroperoxide reductase
KR49_RS01985	COG1615	UPF0182 protein
KR49_RS01990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR49_RS01995	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KR49_RS02010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KR49_RS02015	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KR49_RS02015	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KR49_RS02030	COG2119	membrane
KR49_RS02040	COG0557	exoribonuclease II activity
KR49_RS02045	COG0163	prenyltransferase activity
KR49_RS02060	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KR49_RS02065	COG0312	modulator of DNA gyrase
KR49_RS02075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KR49_RS02090	COG0861	Integral membrane protein TerC family
KR49_RS02135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KR49_RS02150	COG0793	Belongs to the peptidase S41A family
KR49_RS02155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KR49_RS02160	COG1573	uracil-dna glycosylase
KR49_RS02170	COG0436	Aminotransferase
KR49_RS02175	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
KR49_RS02200	COG1836	PFAM Integral membrane protein DUF92
KR49_RS02210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KR49_RS02220	COG1129	ABC transporter
KR49_RS02225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KR49_RS02240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KR49_RS02245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KR49_RS02250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KR49_RS02340	COG1357	PFAM Pentapeptide repeats (8 copies)
KR49_RS02345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KR49_RS02355	COG0129	dihydroxy-acid dehydratase activity
KR49_RS02370	COG0363	glucosamine-6-phosphate deaminase activity
KR49_RS02375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KR49_RS02380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR49_RS02385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KR49_RS02390	COG1494	fructose-1,6-bisphosphatase
KR49_RS02395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KR49_RS02400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KR49_RS02425	COG1217	gtp-binding protein TYPA
KR49_RS02430	COG0826	peptidase U32
KR49_RS02440	COG0644	oxidoreductase
KR49_RS02450	COG0751	glycine-tRNA ligase activity
KR49_RS02455	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KR49_RS02460	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KR49_RS02465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KR49_RS02475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KR49_RS02480	COG0052	Belongs to the universal ribosomal protein uS2 family
KR49_RS02485	COG1216	Glycosyl transferase, family 2
KR49_RS02510	COG0612	Peptidase, M16
KR49_RS02530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KR49_RS02535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KR49_RS02550	COG0590	tRNA wobble adenosine to inosine editing
KR49_RS02550	COG0037	tRNA processing
KR49_RS02555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KR49_RS02565	COG0174	glutamine synthetase
KR49_RS02570	COG2226	methyltransferase
KR49_RS02595	COG0515	serine threonine protein kinase
KR49_RS02600	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
KR49_RS02610	COG0628	permease
KR49_RS02615	COG0628	permease
KR49_RS02630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KR49_RS02635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KR49_RS02640	COG0022	dehydrogenase e1 component
KR49_RS02640	COG0508	dehydrogenase complex catalyzes the overall conversion of
KR49_RS02650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KR49_RS02655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KR49_RS02660	COG0792	nuclease activity
KR49_RS02675	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KR49_RS02695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KR49_RS02715	COG0798	PFAM Bile acid sodium symporter
KR49_RS02720	COG0358	DNA primase activity
KR49_RS02735	COG0632	four-way junction helicase activity
KR49_RS02740	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KR49_RS02750	COG0587	DNA-directed DNA polymerase activity
KR49_RS02755	COG0154	amidase activity
KR49_RS02765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KR49_RS02770	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KR49_RS02780	COG0505	Belongs to the CarA family
KR49_RS02785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KR49_RS02795	COG1132	(ABC) transporter
KR49_RS02805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KR49_RS02820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR49_RS02825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KR49_RS02835	COG2176	DNA-directed DNA polymerase activity
KR49_RS02840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KR49_RS02850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KR49_RS02855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KR49_RS02860	COG0142	geranyltranstransferase activity
KR49_RS02865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KR49_RS02870	COG0860	N-Acetylmuramoyl-L-alanine amidase
KR49_RS02880	COG2045	Belongs to the ComB family
KR49_RS02885	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KR49_RS02890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KR49_RS02900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KR49_RS02905	COG1803	Methylglyoxal synthase
KR49_RS02905	COG1597	lipid kinase activity
KR49_RS02915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KR49_RS02925	COG0297	glycogen (starch) synthase activity
KR49_RS02930	COG1376	ErfK ybiS ycfS ynhG family protein
KR49_RS02935	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KR49_RS02940	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KR49_RS02945	COG0681	Belongs to the peptidase S26 family
KR49_RS03030	COG0701	Predicted permease
KR49_RS03055	COG1121	(ABC) transporter
KR49_RS03075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KR49_RS03095	COG1640	4-alpha-glucanotransferase
KR49_RS03105	COG1187	pseudouridine synthase activity
KR49_RS03110	COG5002	protein histidine kinase activity
KR49_RS03115	COG0745	RESPONSE REGULATOR receiver
KR49_RS03125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KR49_RS03130	COG1982	Orn Lys Arg decarboxylase major
KR49_RS03135	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KR49_RS03140	COG0575	Belongs to the CDS family
KR49_RS03150	COG0596	Alpha beta hydrolase
KR49_RS03155	COG0371	Dehydrogenase
KR49_RS03160	COG0542	response to heat
KR49_RS03165	COG0456	acetyltransferase
KR49_RS03170	COG0019	diaminopimelate decarboxylase activity
KR49_RS03175	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KR49_RS03180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KR49_RS03185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KR49_RS03200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KR49_RS03205	COG1054	Belongs to the UPF0176 family
KR49_RS03230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KR49_RS03245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KR49_RS03260	COG0475	glutathione-regulated potassium exporter activity
KR49_RS03260	COG0589	response to stress
KR49_RS03265	COG1132	(ABC) transporter
KR49_RS03270	COG0724	RNA recognition motif
KR49_RS03285	COG0513	Belongs to the DEAD box helicase family
KR49_RS03315	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KR49_RS03335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KR49_RS03350	COG0271	Belongs to the BolA IbaG family
KR49_RS03355	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KR49_RS03365	COG0745	RESPONSE REGULATOR receiver
KR49_RS03380	COG1233	COG1233 Phytoene dehydrogenase and related
KR49_RS03390	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KR49_RS03535	COG0123	including yeast histone deacetylase and acetoin utilization protein
KR49_RS03575	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KR49_RS03585	COG0735	belongs to the Fur family
KR49_RS03600	COG1799	cell septum assembly
KR49_RS03660	COG2873	o-acetylhomoserine
KR49_RS03665	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KR49_RS03685	COG1126	abc transporter atp-binding protein
KR49_RS03690	COG0765	amino acid transport
KR49_RS03695	COG4597	amino acid ABC transporter
KR49_RS03700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KR49_RS03710	COG0659	secondary active sulfate transmembrane transporter activity
KR49_RS03750	COG0799	negative regulation of ribosome biogenesis
KR49_RS03760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KR49_RS03775	COG1115	amino acid carrier protein
KR49_RS03785	COG1132	(ABC) transporter
KR49_RS03790	COG2501	S4 domain
KR49_RS03795	COG0149	triose-phosphate isomerase activity
KR49_RS03800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KR49_RS03810	COG1429	ligase activity, forming nitrogen-metal bonds
KR49_RS03815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KR49_RS03825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KR49_RS03830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KR49_RS03840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KR49_RS03880	COG2326	polyphosphate kinase activity
KR49_RS03910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KR49_RS03915	COG0640	Transcriptional regulator
KR49_RS03925	COG0668	transmembrane transport
KR49_RS03940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KR49_RS03945	COG0047	phosphoribosylformylglycinamidine synthase activity
KR49_RS03950	COG1619	proteins homologs of microcin C7 resistance protein MccF
KR49_RS03970	COG0191	fructose-bisphosphate aldolase activity
KR49_RS03975	COG0673	inositol 2-dehydrogenase activity
KR49_RS03985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KR49_RS03990	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KR49_RS04000	COG3954	Phosphoribulokinase
KR49_RS04005	COG0473	3-isopropylmalate dehydrogenase activity
KR49_RS04010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KR49_RS04015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KR49_RS04030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KR49_RS04045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KR49_RS04050	COG2197	response regulator
KR49_RS04060	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KR49_RS04075	COG0517	IMP dehydrogenase activity
KR49_RS04085	COG1376	ErfK ybiS ycfS ynhG family protein
KR49_RS04180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR49_RS04190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KR49_RS04220	COG0308	aminopeptidase N
KR49_RS04240	COG2205	protein histidine kinase activity
KR49_RS04260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KR49_RS04270	COG1797	cobyrinic acid a,c-diamide synthase activity
KR49_RS04275	COG1254	Belongs to the acylphosphatase family
KR49_RS04285	COG0406	alpha-ribazole phosphatase activity
KR49_RS04300	COG0142	geranyltranstransferase activity
KR49_RS04310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KR49_RS04315	COG1480	7TM receptor with intracellular HD hydrolase
KR49_RS04325	COG0564	pseudouridine synthase activity
KR49_RS04335	COG0011	TIGRFAM Protein of
KR49_RS04365	COG0395	ABC-type sugar transport system, permease component
KR49_RS04370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KR49_RS04375	COG1543	Belongs to the glycosyl hydrolase 57 family
KR49_RS04380	COG0644	oxidoreductase
KR49_RS04385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KR49_RS04395	COG0516	GMP reductase activity
KR49_RS04400	COG3118	belongs to the thioredoxin family
KR49_RS04405	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KR49_RS04415	COG2010	Cytochrome c
KR49_RS04435	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KR49_RS04440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KR49_RS04470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KR49_RS04480	COG2166	iron-sulfur cluster assembly
KR49_RS04485	COG0460	homoserine dehydrogenase
KR49_RS04500	COG0601	transmembrane transport
KR49_RS04520	COG0012	GTP binding
KR49_RS04530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KR49_RS04530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KR49_RS04535	COG0215	cysteine-tRNA ligase activity
KR49_RS04545	COG0733	neurotransmitter:sodium symporter activity
KR49_RS04550	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KR49_RS04600	COG0492	ferredoxin-NADP+ reductase activity
KR49_RS04605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KR49_RS04615	COG2226	methyltransferase
KR49_RS04640	COG2267	carboxylic ester hydrolase activity
KR49_RS04645	COG0440	acetolactate synthase activity
KR49_RS04650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KR49_RS04670	COG0626	cystathionine gamma-synthase activity
KR49_RS04680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KR49_RS04685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KR49_RS04700	COG1022	Amp-dependent synthetase and ligase
KR49_RS04705	COG0321	lipoyl(octanoyl) transferase activity
KR49_RS04710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KR49_RS04715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KR49_RS04720	COG1381	Involved in DNA repair and RecF pathway recombination
KR49_RS04730	COG0438	transferase activity, transferring glycosyl groups
KR49_RS04735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KR49_RS04740	COG1799	cell septum assembly
KR49_RS04745	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KR49_RS04755	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KR49_RS04760	COG1160	GTP binding
KR49_RS04765	COG1376	ErfK ybiS ycfS ynhG family protein
KR49_RS04775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KR49_RS04790	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KR49_RS04885	COG0114	fumarate hydratase activity
KR49_RS04890	COG4581	dead DEAH box helicase
KR49_RS04900	COG0385	Bile acid
KR49_RS04905	COG0156	8-amino-7-oxononanoate synthase activity
KR49_RS04920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KR49_RS04930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KR49_RS04945	COG0357	Ribosomal RNA small subunit methyltransferase G
KR49_RS04980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KR49_RS04990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KR49_RS04995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KR49_RS05000	COG0085	RNA polymerase activity
KR49_RS05005	COG0084	hydrolase, TatD family'
KR49_RS05010	COG0268	Binds directly to 16S ribosomal RNA
KR49_RS05015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KR49_RS05020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KR49_RS05025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KR49_RS05040	COG0641	radical SAM
KR49_RS05055	COG0779	Required for maturation of 30S ribosomal subunits
KR49_RS05060	COG0195	Participates in both transcription termination and antitermination
KR49_RS05070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KR49_RS05135	COG1053	succinate dehydrogenase
KR49_RS05165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KR49_RS05170	COG0776	regulation of translation
KR49_RS05235	COG2211	Major facilitator Superfamily
KR49_RS05240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KR49_RS05280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KR49_RS05300	COG0284	orotidine-5'-phosphate decarboxylase activity
KR49_RS05310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KR49_RS05320	COG2197	response regulator
KR49_RS05345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KR49_RS05360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KR49_RS05365	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KR49_RS05370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KR49_RS05375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KR49_RS05380	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KR49_RS05390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KR49_RS05400	COG0151	Belongs to the GarS family
KR49_RS05405	COG5002	protein histidine kinase activity
KR49_RS05410	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KR49_RS05415	COG4251	negative regulation of phosphorylation
KR49_RS05425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KR49_RS05430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KR49_RS05435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KR49_RS05440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KR49_RS05445	COG0217	transcriptional regulatory protein
KR49_RS05460	COG0363	glucosamine-6-phosphate deaminase activity
KR49_RS05465	COG2385	sporulation resulting in formation of a cellular spore
KR49_RS05465	COG2247	cell wall binding repeat
KR49_RS05470	COG1234	tRNA 3'-trailer cleavage
KR49_RS05475	COG2010	Cytochrome c
KR49_RS05490	COG2264	protein methyltransferase activity
KR49_RS05495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KR49_RS05515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KR49_RS05550	COG0443	Heat shock 70 kDa protein
KR49_RS05565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KR49_RS05570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KR49_RS05585	COG0459	protein refolding
KR49_RS05590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KR49_RS05595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KR49_RS05600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KR49_RS05615	COG0387	Pfam Sodium calcium exchanger
KR49_RS05620	COG0006	proline dipeptidase activity
KR49_RS05625	COG1253	flavin adenine dinucleotide binding
KR49_RS05630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KR49_RS05635	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KR49_RS05640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KR49_RS05640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KR49_RS05650	COG3012	SEC-C Motif Domain Protein
KR49_RS05655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KR49_RS05665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KR49_RS05675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KR49_RS05680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KR49_RS05685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KR49_RS05690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KR49_RS05695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KR49_RS05700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KR49_RS05705	COG0356	it plays a direct role in the translocation of protons across the membrane
KR49_RS05715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KR49_RS05720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR49_RS05750	COG0772	Belongs to the SEDS family
KR49_RS05760	COG1333	cytochrome c biogenesis protein
KR49_RS05765	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KR49_RS05795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KR49_RS05815	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KR49_RS05825	COG1132	(ABC) transporter
KR49_RS05830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KR49_RS05850	COG0489	protein tyrosine kinase activity
KR49_RS05910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KR49_RS05925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KR49_RS05935	COG3562	capsule polysaccharide
KR49_RS05965	COG2089	acid synthase
KR49_RS06060	COG0116	Belongs to the methyltransferase superfamily
KR49_RS06085	COG1196	nuclear chromosome segregation
KR49_RS06100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KR49_RS06105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KR49_RS06115	COG0439	Biotin carboxylase
KR49_RS06130	COG0515	serine threonine protein kinase
KR49_RS06150	COG4178	(ABC) transporter
KR49_RS06155	COG0537	adenosine 5'-monophosphoramidase activity
KR49_RS06245	COG0242	peptide deformylase activity
KR49_RS06255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KR49_RS06260	COG0719	Fe-S assembly protein
KR49_RS06265	COG0396	ATPase activity
KR49_RS06270	COG0719	Fe-S assembly protein
KR49_RS06275	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
KR49_RS06295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR49_RS06335	COG0033	Phosphoglucomutase
KR49_RS06345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KR49_RS06355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KR49_RS06370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KR49_RS06375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KR49_RS06380	COG0175	sulfate reduction
KR49_RS06385	COG1252	NADH dehydrogenase
KR49_RS06390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KR49_RS06395	COG0471	metal ion transport
KR49_RS06395	COG3273	potassium ion transport
KR49_RS06400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KR49_RS06405	COG0569	domain protein
KR49_RS06410	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KR49_RS06430	COG0488	(ABC) transporter
KR49_RS06435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KR49_RS06450	COG1643	Atp-dependent helicase
KR49_RS06455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KR49_RS06460	COG1570	exodeoxyribonuclease VII activity
KR49_RS06465	COG1722	exodeoxyribonuclease VII activity
KR49_RS06510	COG0483	inositol monophosphate 1-phosphatase activity
KR49_RS06525	COG1968	undecaprenyl-diphosphatase activity
KR49_RS06535	COG1555	photosystem II stabilization
KR49_RS06540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KR49_RS06545	COG4243	Vitamin k epoxide reductase
KR49_RS06550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KR49_RS06565	COG1032	radical SAM domain protein
KR49_RS06595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KR49_RS06625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KR49_RS06630	COG1472	Belongs to the glycosyl hydrolase 3 family
KR49_RS06635	COG0457	Tetratricopeptide repeat
KR49_RS06635	COG0463	Glycosyl transferase, family 2
KR49_RS06640	COG1587	Uroporphyrinogen-III synthase
KR49_RS06655	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
KR49_RS06660	COG0316	Belongs to the HesB IscA family
KR49_RS06680	COG1090	epimerase
KR49_RS06695	COG0484	heat shock protein binding
KR49_RS06700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KR49_RS06705	COG3659	wide pore channel activity
KR49_RS06710	COG3659	wide pore channel activity
KR49_RS06725	COG1215	transferase activity, transferring glycosyl groups
KR49_RS06750	COG1122	ATPase activity
KR49_RS06760	COG0745	RESPONSE REGULATOR receiver
KR49_RS06770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KR49_RS06775	COG2217	Heavy metal translocating P-type atpase
KR49_RS06780	COG3063	Type IV pilus biogenesis stability protein PilW
KR49_RS06785	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KR49_RS06795	COG0416	fatty acid biosynthetic process
KR49_RS06800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KR49_RS06805	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KR49_RS06820	COG1214	PFAM Peptidase M22, glycoprotease
KR49_RS06830	COG0617	tRNA 3'-terminal CCA addition
KR49_RS06835	COG0724	RNA recognition motif
KR49_RS06840	COG1562	ergosterol biosynthetic process
KR49_RS06845	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
KR49_RS06845	COG0493	'glutamate synthase
KR49_RS06860	COG0583	DNA-binding transcription factor activity
KR49_RS06870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KR49_RS06875	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_RS06890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KR49_RS06900	COG2197	response regulator
KR49_RS06905	COG2954	triphosphatase activity
KR49_RS06910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KR49_RS06915	COG0713	ATP synthesis coupled electron transport
KR49_RS06925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_RS06930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KR49_RS06935	COG0372	Belongs to the citrate synthase family
KR49_RS06955	COG1420	regulation of RNA biosynthetic process
KR49_RS06960	COG0133	tryptophan synthase activity
KR49_RS06970	COG0023	Translation Initiation Factor
KR49_RS06975	COG0529	Catalyzes the synthesis of activated sulfate
KR49_RS06980	COG0628	permease
KR49_RS06985	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KR49_RS06995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KR49_RS07010	COG0564	pseudouridine synthase activity
KR49_RS07015	COG0745	RESPONSE REGULATOR receiver
KR49_RS07025	COG1104	cysteine desulfurase activity
KR49_RS07040	COG0275	rRNA processing
KR49_RS07045	COG0649	NAD binding
KR49_RS07050	COG0824	Thioesterase
KR49_RS07055	COG0318	PFAM AMP-dependent synthetase and ligase
KR49_RS07065	COG1575	Belongs to the MenA family. Type 1 subfamily
KR49_RS07075	COG0189	ligase activity
KR49_RS07080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KR49_RS07085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KR49_RS07090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KR49_RS07095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KR49_RS07115	COG0252	asparaginase activity
KR49_RS07120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KR49_RS07125	COG0018	arginyl-trna synthetase
KR49_RS07130	COG0157	Belongs to the NadC ModD family
KR49_RS07135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KR49_RS07145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KR49_RS07150	COG4172	Belongs to the ABC transporter superfamily
KR49_RS07155	COG0564	pseudouridine synthase activity
KR49_RS07160	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KR49_RS07165	COG0589	response to stress
KR49_RS07170	COG0126	phosphoglycerate kinase activity
KR49_RS07200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KR49_RS07205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KR49_RS07235	COG0167	dihydroorotate dehydrogenase activity
KR49_RS07240	COG0328	RNA-DNA hybrid ribonuclease activity
KR49_RS07250	COG0222	ribosome binding
KR49_RS07255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KR49_RS07260	COG0081	regulation of translation
KR49_RS07265	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KR49_RS07270	COG0250	Participates in transcription elongation, termination and antitermination
KR49_RS07275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KR49_RS07280	COG0542	response to heat
KR49_RS07285	COG0346	lactoylglutathione lyase activity
KR49_RS07290	COG0148	phosphopyruvate hydratase activity
KR49_RS07300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KR49_RS07335	COG3119	arylsulfatase activity
KR49_RS07345	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KR49_RS07350	COG0237	dephospho-CoA kinase activity
KR49_RS07360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KR49_RS07365	COG2022	thiamine diphosphate biosynthetic process
KR49_RS07365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KR49_RS07370	COG0105	UTP biosynthetic process
KR49_RS07375	COG1166	arginine decarboxylase activity
KR49_RS07380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KR49_RS07390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KR49_RS07415	COG0426	domain, Protein
KR49_RS07415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KR49_RS07420	COG0426	domain, Protein
KR49_RS07420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KR49_RS07425	COG1773	rubredoxin
KR49_RS07435	COG1741	Belongs to the pirin family
KR49_RS07450	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KR49_RS07450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KR49_RS07455	COG0509	glycine decarboxylation via glycine cleavage system
KR49_RS07460	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KR49_RS07470	COG0359	binds to the 23S rRNA
KR49_RS07475	COG0305	Participates in initiation and elongation during chromosome replication
KR49_RS07475	COG1372	Participates in initiation and elongation during chromosome replication
KR49_RS07475	COG0305	Participates in initiation and elongation during chromosome replication
KR49_RS07475	COG1372	Participates in initiation and elongation during chromosome replication
KR49_RS07485	COG0445	tRNA wobble uridine modification
KR49_RS07525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KR49_RS07540	COG0398	Pfam SNARE associated Golgi protein
KR49_RS07560	COG0525	valine-tRNA ligase activity
KR49_RS07565	COG2182	Extracellular solute-binding protein
KR49_RS07570	COG0668	transmembrane transport
KR49_RS07590	COG4221	oxidoreductase activity
KR49_RS07595	COG3604	Transcriptional regulator
KR49_RS07635	COG3956	TIGRFAM MazG family protein
KR49_RS07645	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KR49_RS07650	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KR49_RS07655	COG0010	Belongs to the arginase family
KR49_RS07670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KR49_RS07675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KR49_RS07680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_RS07685	COG0783	Belongs to the Dps family
KR49_RS07690	COG0504	CTP synthase activity
KR49_RS07695	COG0602	queuosine metabolic process
KR49_RS07710	COG1404	Belongs to the peptidase S8 family
KR49_RS07730	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KR49_RS07750	COG0366	Alpha amylase catalytic
KR49_RS07755	COG0463	Glycosyl transferase, family 2
KR49_RS07780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KR49_RS07815	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KR49_RS07820	COG0830	nickel cation binding
KR49_RS07825	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KR49_RS07830	COG0829	nickel cation binding
KR49_RS07835	COG0831	urea catabolic process
KR49_RS07840	COG0832	Belongs to the urease beta subunit family
KR49_RS07845	COG0804	urea catabolic process
KR49_RS07850	COG0505	Belongs to the CarA family
KR49_RS07855	COG2308	Evidence 4 Homologs of previously reported genes of
KR49_RS07875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KR49_RS07885	COG2223	nitrite transmembrane transporter activity
KR49_RS07890	COG0243	molybdopterin cofactor binding
KR49_RS07910	COG0315	cyclic pyranopterin monophosphate synthase activity
KR49_RS07915	COG0303	'Molybdopterin
KR49_RS07935	COG0521	Mo-molybdopterin cofactor biosynthetic process
KR49_RS07940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KR49_RS07950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KR49_RS07960	COG2116	formate transmembrane transporter activity
KR49_RS07970	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
KR49_RS07980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KR49_RS07995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KR49_RS08000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_RS08015	COG0170	dolichyl monophosphate biosynthetic process
KR49_RS08020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KR49_RS08025	COG1049	propionate catabolic process, 2-methylcitrate cycle
KR49_RS08035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KR49_RS08045	COG0788	formyltetrahydrofolate deformylase activity
KR49_RS08055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KR49_RS08065	COG0443	Heat shock 70 kDa protein
KR49_RS08070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KR49_RS08080	COG0360	Binds together with S18 to 16S ribosomal RNA
KR49_RS08090	COG0137	argininosuccinate synthase activity
KR49_RS08105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KR49_RS08115	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KR49_RS08120	COG0438	transferase activity, transferring glycosyl groups
KR49_RS08130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KR49_RS08135	COG0497	DNA recombination
KR49_RS08140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KR49_RS08150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KR49_RS08155	COG0592	DNA-directed DNA polymerase activity
KR49_RS08165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KR49_RS08170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KR49_RS08175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KR49_RS08185	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KR49_RS08200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KR49_RS08205	COG0552	protein localization to endoplasmic reticulum
KR49_RS08210	COG2208	phosphoserine phosphatase activity
KR49_RS08215	COG0165	Argininosuccinate lyase
KR49_RS08220	COG0724	RNA recognition motif
KR49_RS08225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KR49_RS08230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KR49_RS08235	COG2081	HI0933 family
KR49_RS08240	COG1459	type II secretion system
KR49_RS08250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KR49_RS08255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KR49_RS08260	COG0484	heat shock protein binding
KR49_RS08270	COG1162	GTPase activity
KR49_RS08275	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KR49_RS08280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KR49_RS08285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KR49_RS08290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KR49_RS08295	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KR49_RS08300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KR49_RS08305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KR49_RS08310	COG0511	ligase activity, forming carbon-carbon bonds
KR49_RS08315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KR49_RS08385	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
KR49_RS08390	COG0519	Catalyzes the synthesis of GMP from XMP
KR49_RS08390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KR49_RS08405	COG0768	penicillin binding
KR49_RS08410	COG0438	transferase activity, transferring glycosyl groups
KR49_RS08415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KR49_RS08425	COG2022	thiamine diphosphate biosynthetic process
KR49_RS08440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KR49_RS08445	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KR49_RS08450	COG2385	sporulation resulting in formation of a cellular spore
KR49_RS08450	COG2247	cell wall binding repeat
KR49_RS08455	COG1215	transferase activity, transferring glycosyl groups
KR49_RS08460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KR49_RS08470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KR49_RS08475	COG0740	serine-type endopeptidase activity
KR49_RS08480	COG0544	peptidyl-prolyl cis-trans isomerase activity
KR49_RS08490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KR49_RS08495	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KR49_RS08515	COG2082	Precorrin-8x methylmutase
KR49_RS08520	COG0037	tRNA processing
KR49_RS08535	COG0556	nucleotide-excision repair
KR49_RS08540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KR49_RS08550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KR49_RS08565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KR49_RS08635	COG0653	protein targeting
KR49_RS08655	COG1045	serine acetyltransferase
KR49_RS08660	COG1725	Transcriptional regulator
KR49_RS08665	COG0412	Dienelactone hydrolase
KR49_RS08670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KR49_RS08675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KR49_RS08680	COG0187	DNA topoisomerase II activity
KR49_RS08680	COG1372	Participates in initiation and elongation during chromosome replication
KR49_RS08690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KR49_RS08695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KR49_RS08705	COG0386	Belongs to the glutathione peroxidase family
KR49_RS08710	COG2239	Acts as a magnesium transporter
KR49_RS08715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_RS08720	COG0596	Alpha beta hydrolase
KR49_RS08730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KR49_RS08735	COG0802	atpase or kinase
KR49_RS08740	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KR49_RS08745	COG0586	Pfam SNARE associated Golgi protein
KR49_RS08750	COG0629	single-stranded DNA binding
KR49_RS08760	COG1792	Involved in formation and maintenance of cell shape
KR49_RS08775	COG0745	RESPONSE REGULATOR receiver
KR49_RS08780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KR49_RS08800	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KR49_RS08805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KR49_RS08810	COG3266	domain, Protein
KR49_RS08810	COG0515	serine threonine protein kinase
KR49_RS08815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KR49_RS08820	COG2255	four-way junction helicase activity
KR49_RS08830	COG1473	amidohydrolase
KR49_RS08850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KR49_RS08855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KR49_RS08860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KR49_RS08865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KR49_RS08870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_RS08875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KR49_RS08880	COG0598	Magnesium transport protein CorA
KR49_RS08890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KR49_RS08900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR49_RS08905	COG0571	ribonuclease III activity
KR49_RS08935	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KR49_RS08940	COG0058	SHG alpha-glucan phosphorylase activity
KR49_RS08945	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KR49_RS08950	COG0475	glutathione-regulated potassium exporter activity
KR49_RS08970	COG0277	FAD linked oxidase domain protein
KR49_RS08980	COG0247	lactate metabolic process
KR49_RS08990	COG0538	isocitrate dehydrogenase activity
KR49_RS08995	COG0463	Glycosyl transferase, family 2
KR49_RS09005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KR49_RS09015	COG5398	heme oxygenase
KR49_RS09030	COG0438	transferase activity, transferring glycosyl groups
KR49_RS09040	COG0438	transferase activity, transferring glycosyl groups
KR49_RS09045	COG0297	glycogen (starch) synthase activity
KR49_RS09065	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KR49_RS09070	COG0463	Glycosyl transferase, family 2
KR49_RS09090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KR49_RS09095	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KR49_RS09100	COG0517	IMP dehydrogenase activity
KR49_RS09100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KR49_RS09105	COG0517	IMP dehydrogenase activity
KR49_RS09105	COG0617	tRNA 3'-terminal CCA addition
KR49_RS09105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KR49_RS09115	COG0709	Synthesizes selenophosphate from selenide and ATP
KR49_RS09120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KR49_RS09130	COG2274	protein secretion by the type I secretion system
KR49_RS09140	COG0438	transferase activity, transferring glycosyl groups
KR49_RS09145	COG0124	histidyl-tRNA synthetase
KR49_RS09155	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KR49_RS09185	COG4447	cellulose binding
KR49_RS09190	COG1773	rubredoxin
KR49_RS09195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_RS09200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_RS09205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_RS09210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KR49_RS09215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KR49_RS09225	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KR49_RS09225	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KR49_RS09230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KR49_RS09235	COG0494	nUDIX hydrolase
KR49_RS09240	COG0415	Belongs to the DNA photolyase family
KR49_RS09270	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KR49_RS09275	COG0131	Imidazoleglycerol-phosphate dehydratase
KR49_RS09280	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
KR49_RS09290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KR49_RS09310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KR49_RS09315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KR49_RS09325	COG0354	folic acid binding
KR49_RS09330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KR49_RS09340	COG1253	flavin adenine dinucleotide binding
KR49_RS09345	COG0673	inositol 2-dehydrogenase activity
KR49_RS09365	COG0343	queuine tRNA-ribosyltransferase activity
KR49_RS09390	COG0138	bifunctional purine biosynthesis protein purh
KR49_RS09405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KR49_RS09410	COG0004	ammonium transporteR
KR49_RS09415	COG1489	DNA binding
KR49_RS09420	COG0728	peptidoglycan biosynthetic process
KR49_RS09445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KR49_RS09450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KR49_RS09455	COG1058	Belongs to the CinA family
KR49_RS09455	COG1546	Belongs to the CinA family
KR49_RS09460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KR49_RS09465	COG0066	3-isopropylmalate dehydratase activity
KR49_RS09500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KR49_RS09505	COG0193	aminoacyl-tRNA hydrolase activity
KR49_RS09520	COG4372	Transposase
KR49_RS09525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR49_RS09530	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KR49_RS09540	COG0717	Belongs to the dCTP deaminase family
KR49_RS09550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KR49_RS09560	COG0741	lytic transglycosylase activity
KR49_RS09570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KR49_RS09575	COG2971	BadF BadG BcrA BcrD
KR49_RS09585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KR49_RS09605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KR49_RS09625	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KR49_RS09640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KR49_RS09645	COG2094	Belongs to the DNA glycosylase MPG family
KR49_RS09650	COG0540	Belongs to the ATCase OTCase family
KR49_RS09675	COG3536	Protein conserved in bacteria
KR49_RS09680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KR49_RS09690	COG2046	Belongs to the sulfate adenylyltransferase family
KR49_RS09690	COG0529	Catalyzes the synthesis of activated sulfate
KR49_RS09695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR49_RS09700	COG0800	Aldolase
KR49_RS09710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KR49_RS09755	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KR49_RS09760	COG0436	Aminotransferase
KR49_RS09770	COG1530	ribonuclease E activity
KR49_RS09790	COG2226	methyltransferase
KR49_RS09795	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KR49_RS09800	COG0051	transcription antitermination factor activity, RNA binding
KR49_RS09805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KR49_RS09810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KR49_RS09815	COG0049	tRNA binding
KR49_RS09820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KR49_RS09835	COG0067	glutamate synthase
KR49_RS09835	COG0069	glutamate synthase activity
KR49_RS09835	COG0070	glutamate synthase
KR49_RS09845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KR49_RS09860	COG3659	wide pore channel activity
KR49_RS09875	COG1840	ABC-type Fe3 transport system, periplasmic component
KR49_RS09890	COG3659	wide pore channel activity
KR49_RS09895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KR49_RS09915	COG2885	chlorophyll binding
KR49_RS09920	COG2885	chlorophyll binding
KR49_RS09960	COG0463	Glycosyl transferase, family 2
KR49_RS09985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KR49_RS09995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KR49_RS10000	COG0254	rRNA binding
KR49_RS10005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KR49_RS10010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KR49_RS10015	COG0101	tRNA pseudouridine synthase activity
KR49_RS10020	COG0203	ribosomal protein L17
KR49_RS10025	COG0202	RNA polymerase activity
KR49_RS10030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KR49_RS10035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KR49_RS10040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KR49_RS10045	COG0563	adenylate kinase activity
KR49_RS10050	COG0201	protein transport
KR49_RS10055	COG0200	Binds to the 23S rRNA
KR49_RS10060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KR49_RS10075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KR49_RS10080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KR49_RS10085	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KR49_RS10090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KR49_RS10095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KR49_RS10100	COG0255	Belongs to the universal ribosomal protein uL29 family
KR49_RS10105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KR49_RS10110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KR49_RS10115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KR49_RS10120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KR49_RS10125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KR49_RS10130	COG0089	rRNA binding
KR49_RS10135	COG0088	Forms part of the polypeptide exit tunnel
KR49_RS10140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KR49_RS10155	COG3854	ATPases associated with a variety of cellular activities
KR49_RS10170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KR49_RS10200	COG3001	Fructosamine kinase
KR49_RS10220	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
KR49_RS10225	COG1606	tRNA processing
KR49_RS10230	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KR49_RS10235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KR49_RS10250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KR49_RS10260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KR49_RS10275	COG0772	Belongs to the SEDS family
KR49_RS10280	COG0489	protein tyrosine kinase activity
KR49_RS10285	COG0408	coproporphyrinogen oxidase activity
KR49_RS10305	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KR49_RS10335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KR49_RS10340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KR49_RS10345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KR49_RS10345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KR49_RS10350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KR49_RS10410	COG0237	dephospho-CoA kinase activity
KR49_RS10480	COG0237	dephospho-CoA kinase activity
KR49_RS10500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KR49_RS10535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KR49_RS10545	COG1070	Carbohydrate kinase
KR49_RS10550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KR49_RS10560	COG0539	negative regulation of cytoplasmic translation
KR49_RS10565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KR49_RS10600	COG0758	DNA mediated transformation
KR49_RS10600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KR49_RS10605	COG2890	protein-(glutamine-N5) methyltransferase activity
KR49_RS10620	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KR49_RS10625	COG2894	cell division
KR49_RS10630	COG0850	regulation of cytokinetic process
KR49_RS10635	COG1078	dGTPase activity
KR49_RS10640	COG0793	Belongs to the peptidase S41A family
KR49_RS10645	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KR49_RS10650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KR49_RS10685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KR49_RS10700	COG0514	ATP-dependent DNA helicase (RecQ)
KR49_RS10705	COG3942	CHAP domain
KR49_RS10705	COG1388	LysM domain
KR49_RS10710	COG1012	belongs to the aldehyde dehydrogenase family
KR49_RS10720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KR49_RS10745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KR49_RS10755	COG0659	secondary active sulfate transmembrane transporter activity
KR49_RS10765	COG0484	heat shock protein binding
KR49_RS10770	COG0113	porphobilinogen synthase activity
KR49_RS10780	COG1193	negative regulation of DNA recombination
KR49_RS10785	COG3842	ATPase activity
KR49_RS10790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KR49_RS10805	COG0488	(ABC) transporter
KR49_RS10815	COG0435	Glutathione S-transferase
KR49_RS10820	COG2988	succinylglutamate desuccinylase activity
KR49_RS10865	COG4176	ABC-type proline glycine betaine transport system permease component
KR49_RS10875	COG2226	methyltransferase
KR49_RS10880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KR49_RS10920	COG5183	chlorophyll binding
KR49_RS10920	COG2133	pyrroloquinoline quinone binding
KR49_RS10980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KR49_RS10990	COG1185	polyribonucleotide nucleotidyltransferase activity
KR49_RS10995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KR49_RS11000	COG0750	zinc metalloprotease
KR49_RS11005	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KR49_RS11020	COG0706	membrane insertase activity
KR49_RS11030	COG0594	ribonuclease P activity
KR49_RS11050	COG0616	signal peptide processing
KR49_RS11055	COG0697	spore germination
KR49_RS11060	COG0438	transferase activity, transferring glycosyl groups
KR49_RS11065	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KR49_RS11075	COG1842	Phage shock protein A
KR49_RS11080	COG3118	belongs to the thioredoxin family
KR49_RS11085	COG0436	Aminotransferase
KR49_RS11090	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KR49_RS11090	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KR49_RS11095	COG0739	heme binding
KR49_RS11100	COG0745	RESPONSE REGULATOR receiver
KR49_RS11110	COG0577	efflux transmembrane transporter activity
KR49_RS11110	COG1136	(ABC) transporter
KR49_RS11115	COG1007	ATP synthesis coupled electron transport
KR49_RS11120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KR49_RS11135	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KR49_RS11165	COG1845	cytochrome c oxidase, subunit III
KR49_RS11180	COG1612	heme a metabolic process
KR49_RS11185	COG0109	protoheme IX farnesyltransferase activity
KR49_RS11205	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KR49_RS11210	COG0459	protein refolding
KR49_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
KR49_RS11230	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KR49_RS11235	COG1619	proteins homologs of microcin C7 resistance protein MccF
KR49_RS11240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KR49_RS11245	COG0248	Ppx GppA phosphatase
KR49_RS11260	COG2875	Belongs to the precorrin methyltransferase family
KR49_RS11265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KR49_RS11270	COG0739	heme binding
KR49_RS11275	COG0723	plastoquinol--plastocyanin reductase activity
KR49_RS11285	COG0805	protein transport
KR49_RS11290	COG1293	RNA-binding protein homologous to eukaryotic snRNP
KR49_RS11295	COG0194	GDP metabolic process
KR49_RS11310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KR49_RS11315	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KR49_RS11345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KR49_RS11365	COG0335	large ribosomal subunit rRNA binding
KR49_RS11375	COG0024	Methionine aminopeptidase
KR49_RS11380	COG3000	fatty acid hydroxylase
KR49_RS11380	COG0300	oxidoreductase activity
KR49_RS11390	COG0857	belongs to the CobB CobQ family
KR49_RS11405	COG1666	GTP binding
KR49_RS11425	COG0295	cytidine deaminase activity
KR49_RS11435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KR49_RS11440	COG0277	FAD linked oxidase domain protein
KR49_RS11445	COG0708	Exodeoxyribonuclease III
KR49_RS11465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KR49_RS11470	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KR49_RS11495	COG1840	ABC-type Fe3 transport system, periplasmic component
KR49_RS11500	COG0523	cobalamin synthesis protein
KR49_RS11505	COG2154	pterin-4-alpha-carbinolamine dehydratase
KR49_RS11510	COG0432	Pfam Uncharacterised protein family UPF0047
KR49_RS11520	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KR49_RS11525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KR49_RS11540	COG0181	hydroxymethylbilane synthase activity
KR49_RS11560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_RS11565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KR49_RS11575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KR49_RS11590	COG0629	single-stranded DNA binding
KR49_RS11595	COG2099	Precorrin-6x reductase
KR49_RS11600	COG1324	tolerance protein
KR49_RS11605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KR49_RS11610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KR49_RS11620	COG0442	prolyl-tRNA aminoacylation
KR49_RS11635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KR49_RS11660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KR49_RS11665	COG0406	alpha-ribazole phosphatase activity
KR49_RS11680	COG0768	penicillin binding
KR49_RS11685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KR49_RS11700	COG0415	Belongs to the DNA photolyase family
KR49_RS11715	COG0233	cytoplasmic translational termination
KR49_RS11720	COG0528	UMP kinase activity
KR49_RS11735	COG2226	methyltransferase
KR49_RS11745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KR49_RS11750	COG0028	Belongs to the TPP enzyme family
KR49_RS11765	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KR49_RS11770	COG1496	oxidoreductase activity
KR49_RS11780	COG0539	negative regulation of cytoplasmic translation
KR49_RS11790	COG3396	Phenylacetate-CoA oxygenase
KR49_RS11795	COG5322	oxidoreductase activity
KR49_RS11800	COG0825	malonyl-CoA metabolic process
KR49_RS11805	COG4221	oxidoreductase activity
KR49_RS11810	COG0302	gtp cyclohydrolase
KR49_RS11820	COG0135	phosphoribosylanthranilate isomerase activity
KR49_RS11825	COG1994	Peptidase M50
KR49_RS11825	COG0517	IMP dehydrogenase activity
KR49_RS11835	COG0730	response to heat
KR49_RS11860	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
KR49_RS11865	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
KR49_RS11870	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
KR49_RS11880	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
KR49_RS11885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KR49_RS11890	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
KR49_RS11895	COG1850	ribulose-bisphosphate carboxylase activity
KR49_RS11900	COG4451	ribulose bisphosphate carboxylase, small
KR49_RS11925	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
KR49_RS11930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KR49_RS11935	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KR49_RS11965	COG1492	cobalamin metabolic process
KR49_RS11975	COG0424	maF-like protein
KR49_RS11980	COG0668	transmembrane transport
KR49_RS12005	COG0367	asparagine synthase
KR49_RS12010	COG0540	Belongs to the ATCase OTCase family
KR49_RS12020	COG3239	Fatty acid desaturase
KR49_RS12025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KR49_RS12030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KR49_RS12040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KR49_RS12045	COG0668	transmembrane transport
KR49_RS12070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KR49_RS12075	COG0579	oxidoreductase
KR49_RS12085	COG0481	GTPase activity
KR49_RS12115	COG0745	RESPONSE REGULATOR receiver
KR49_RS12145	COG5002	protein histidine kinase activity
KR49_RS12145	COG3850	Histidine kinase
KR49_RS12160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KR49_RS12175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KR49_RS12175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KR49_RS12180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KR49_RS12185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KR49_RS12195	COG0107	imidazoleglycerol-phosphate synthase activity
KR49_RS12205	COG2226	methyltransferase
KR49_RS12225	COG0752	glycyl-tRNA synthetase alpha subunit
KR49_RS12240	COG0582	viral genome integration into host DNA
KR49_RS12505	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KR49_RS12510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KR49_RS12515	COG0740	serine-type endopeptidase activity
KR49_RS12520	COG0740	serine-type endopeptidase activity
KR49_RS12525	COG4956	integral membrane protein (PIN domain superfamily)
KR49_RS12530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KR49_RS12535	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KR49_RS12550	COG1181	Belongs to the D-alanine--D-alanine ligase family
KR49_RS12555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KR49_RS12560	COG4948	Mandelate Racemase Muconate Lactonizing
KR49_RS12595	COG0285	dihydrofolate synthase activity
KR49_RS12600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KR49_RS12605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KR49_RS12610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KR49_RS12625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KR49_RS12630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KR49_RS12665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KR49_RS12670	COG0482	sulfurtransferase activity
KR49_RS12675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KR49_RS12680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KR49_RS12690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KR49_RS12695	COG0228	four-way junction DNA binding
KR49_RS12700	COG1702	phosphate starvation-inducible protein PhoH
KR49_RS12705	COG0670	Belongs to the BI1 family
KR49_RS12715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KR49_RS12730	COG0336	Belongs to the RNA methyltransferase TrmD family
KR49_RS12740	COG1691	(AIR) carboxylase
KR49_RS12755	COG0352	thiamine-phosphate diphosphorylase activity
KR49_RS12765	COG0196	riboflavin kinase activity
KR49_RS12775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KR49_RS12780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KR49_RS12785	COG3119	arylsulfatase activity
KR49_RS12790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KR49_RS12845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KR49_RS12850	COG0745	RESPONSE REGULATOR receiver
KR49_RS12890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KR49_RS12890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KR49_RS13075	COG4974	Belongs to the 'phage' integrase family
KR49_RS13095	COG5183	chlorophyll binding
KR49_RS13095	COG2133	pyrroloquinoline quinone binding
KR49_RS13275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KR49_RS13290	COG2226	methyltransferase
KR49_RS13295	COG3754	Rhamnan synthesis protein F
KR49_RS13370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KR49_RS13375	COG3128	pkhd-type hydroxylase
KR49_RS13415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KR49_RS13420	COG4968	Prepilin-type N-terminal cleavage methylation domain
KR49_RS13450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KR49_RS13460	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity