locus-tag	class	description
SynMINOS11_RS00005	COG0592	DNA-directed DNA polymerase activity
SynMINOS11_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynMINOS11_RS00020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynMINOS11_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynMINOS11_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynMINOS11_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynMINOS11_RS00055	COG0552	protein localization to endoplasmic reticulum
SynMINOS11_RS00060	COG2208	phosphoserine phosphatase activity
SynMINOS11_RS00065	COG0165	Argininosuccinate lyase
SynMINOS11_RS00070	COG0724	RNA recognition motif
SynMINOS11_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynMINOS11_RS00085	COG2081	HI0933 family
SynMINOS11_RS00090	COG1459	type II secretion system
SynMINOS11_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynMINOS11_RS00105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynMINOS11_RS00110	COG0484	heat shock protein binding
SynMINOS11_RS00125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynMINOS11_RS00130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynMINOS11_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynMINOS11_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynMINOS11_RS00145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynMINOS11_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMINOS11_RS00155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynMINOS11_RS00160	COG0511	ligase activity, forming carbon-carbon bonds
SynMINOS11_RS00165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynMINOS11_RS00190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynMINOS11_RS00210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynMINOS11_RS00250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynMINOS11_RS00250	COG0519	Catalyzes the synthesis of GMP from XMP
SynMINOS11_RS00270	COG0768	penicillin binding
SynMINOS11_RS00275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynMINOS11_RS00275	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_RS00280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynMINOS11_RS00290	COG2022	thiamine diphosphate biosynthetic process
SynMINOS11_RS00305	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynMINOS11_RS00310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynMINOS11_RS00315	COG2385	sporulation resulting in formation of a cellular spore
SynMINOS11_RS00320	COG1215	transferase activity, transferring glycosyl groups
SynMINOS11_RS00325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynMINOS11_RS00335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynMINOS11_RS00340	COG0740	serine-type endopeptidase activity
SynMINOS11_RS00345	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynMINOS11_RS00350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynMINOS11_RS00355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynMINOS11_RS00360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynMINOS11_RS00370	COG0037	tRNA processing
SynMINOS11_RS00380	COG0556	nucleotide-excision repair
SynMINOS11_RS00385	COG0527	aspartate kinase activity
SynMINOS11_RS00395	COG2082	Precorrin-8x methylmutase
SynMINOS11_RS00400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynMINOS11_RS00410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynMINOS11_RS00430	COG1088	dTDP-glucose 4,6-dehydratase activity
SynMINOS11_RS00440	COG0454	-acetyltransferase
SynMINOS11_RS00445	COG0653	protein targeting
SynMINOS11_RS00450	COG1045	serine acetyltransferase
SynMINOS11_RS00455	COG1725	Transcriptional regulator
SynMINOS11_RS00460	COG0412	Dienelactone hydrolase
SynMINOS11_RS00465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynMINOS11_RS00470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynMINOS11_RS00475	COG0187	DNA topoisomerase II activity
SynMINOS11_RS00475	COG1372	Participates in initiation and elongation during chromosome replication
SynMINOS11_RS00485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynMINOS11_RS00490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynMINOS11_RS00495	COG0386	Belongs to the glutathione peroxidase family
SynMINOS11_RS00500	COG2239	Acts as a magnesium transporter
SynMINOS11_RS00505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_RS00525	COG0802	atpase or kinase
SynMINOS11_RS00530	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynMINOS11_RS00535	COG0586	Pfam SNARE associated Golgi protein
SynMINOS11_RS00540	COG0629	single-stranded DNA binding
SynMINOS11_RS00565	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_RS00570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynMINOS11_RS00600	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynMINOS11_RS00605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynMINOS11_RS00615	COG0515	serine threonine protein kinase
SynMINOS11_RS00620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynMINOS11_RS00625	COG2255	four-way junction helicase activity
SynMINOS11_RS00635	COG1473	amidohydrolase
SynMINOS11_RS00650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynMINOS11_RS00655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynMINOS11_RS00660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynMINOS11_RS00665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynMINOS11_RS00670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_RS00675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynMINOS11_RS00680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynMINOS11_RS00690	COG0571	ribonuclease III activity
SynMINOS11_RS00695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SynMINOS11_RS00695	COG2755	lipolytic protein G-D-S-L family
SynMINOS11_RS00720	COG0058	SHG alpha-glucan phosphorylase activity
SynMINOS11_RS00745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SynMINOS11_RS00745	COG2755	lipolytic protein G-D-S-L family
SynMINOS11_RS00750	COG0277	FAD linked oxidase domain protein
SynMINOS11_RS00760	COG0247	lactate metabolic process
SynMINOS11_RS00765	COG2192	nodulation
SynMINOS11_RS00785	COG0538	isocitrate dehydrogenase activity
SynMINOS11_RS00795	COG5398	heme oxygenase
SynMINOS11_RS00805	COG1132	(ABC) transporter
SynMINOS11_RS00810	COG0124	histidyl-tRNA synthetase
SynMINOS11_RS00815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynMINOS11_RS00820	COG0709	Synthesizes selenophosphate from selenide and ATP
SynMINOS11_RS00840	COG0617	tRNA 3'-terminal CCA addition
SynMINOS11_RS00880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynMINOS11_RS00885	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_RS00890	COG0367	asparagine synthase
SynMINOS11_RS00905	COG0463	Glycosyl transferase, family 2
SynMINOS11_RS00955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynMINOS11_RS00960	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynMINOS11_RS00965	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynMINOS11_RS00970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynMINOS11_RS00985	COG1083	cytidylyl-transferase
SynMINOS11_RS00990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynMINOS11_RS01035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SynMINOS11_RS01045	COG0463	Glycosyl transferase, family 2
SynMINOS11_RS01080	COG1063	alcohol dehydrogenase
SynMINOS11_RS01085	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SynMINOS11_RS01115	COG4447	cellulose binding
SynMINOS11_RS01120	COG1773	rubredoxin
SynMINOS11_RS01125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_RS01130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_RS01135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_RS01145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynMINOS11_RS01150	COG3842	ATPase activity
SynMINOS11_RS01160	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMINOS11_RS01160	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMINOS11_RS01175	COG0494	nUDIX hydrolase
SynMINOS11_RS01180	COG0415	Belongs to the DNA photolyase family
SynMINOS11_RS01185	COG2197	response regulator
SynMINOS11_RS01195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynMINOS11_RS01210	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_RS01215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynMINOS11_RS01225	COG0583	DNA-binding transcription factor activity
SynMINOS11_RS01240	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynMINOS11_RS01240	COG0493	'glutamate synthase
SynMINOS11_RS01245	COG1562	ergosterol biosynthetic process
SynMINOS11_RS01260	COG0617	tRNA 3'-terminal CCA addition
SynMINOS11_RS01270	COG1214	PFAM Peptidase M22, glycoprotease
SynMINOS11_RS01285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynMINOS11_RS01290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynMINOS11_RS01295	COG0416	fatty acid biosynthetic process
SynMINOS11_RS01300	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_RS01305	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynMINOS11_RS01310	COG0457	Tetratricopeptide repeat
SynMINOS11_RS01315	COG2217	Heavy metal translocating P-type atpase
SynMINOS11_RS01320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynMINOS11_RS01325	COG0470	DNA polymerase III
SynMINOS11_RS01330	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_RS01340	COG1122	ATPase activity
SynMINOS11_RS01375	COG3659	wide pore channel activity
SynMINOS11_RS01375	COG3659	wide pore channel activity
SynMINOS11_RS01380	COG3659	wide pore channel activity
SynMINOS11_RS01380	COG3659	wide pore channel activity
SynMINOS11_RS01385	COG0859	PFAM glycosyl transferase family 9
SynMINOS11_RS01385	COG0457	Tetratricopeptide repeat
SynMINOS11_RS01390	COG0859	PFAM glycosyl transferase family 9
SynMINOS11_RS01390	COG0457	Tetratricopeptide repeat
SynMINOS11_RS01395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynMINOS11_RS01400	COG0484	heat shock protein binding
SynMINOS11_RS01410	COG1090	epimerase
SynMINOS11_RS01435	COG0316	Belongs to the HesB IscA family
SynMINOS11_RS01440	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynMINOS11_RS01455	COG1587	Uroporphyrinogen-III synthase
SynMINOS11_RS01460	COG0463	Glycosyl transferase, family 2
SynMINOS11_RS01460	COG0457	Tetratricopeptide repeat
SynMINOS11_RS01465	COG1472	Belongs to the glycosyl hydrolase 3 family
SynMINOS11_RS01470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynMINOS11_RS01485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynMINOS11_RS01485	COG0517	IMP dehydrogenase activity
SynMINOS11_RS01490	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynMINOS11_RS01495	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynMINOS11_RS01500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynMINOS11_RS01525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynMINOS11_RS01555	COG1032	radical SAM domain protein
SynMINOS11_RS01570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynMINOS11_RS01575	COG0434	BtpA family
SynMINOS11_RS01580	COG4243	Vitamin k epoxide reductase
SynMINOS11_RS01585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynMINOS11_RS01590	COG1555	photosystem II stabilization
SynMINOS11_RS01600	COG1968	undecaprenyl-diphosphatase activity
SynMINOS11_RS01615	COG2211	Major facilitator Superfamily
SynMINOS11_RS01620	COG0483	inositol monophosphate 1-phosphatase activity
SynMINOS11_RS01625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynMINOS11_RS01635	COG1193	negative regulation of DNA recombination
SynMINOS11_RS01645	COG0113	porphobilinogen synthase activity
SynMINOS11_RS01650	COG0484	heat shock protein binding
SynMINOS11_RS01730	COG0116	Belongs to the methyltransferase superfamily
SynMINOS11_RS01745	COG1196	nuclear chromosome segregation
SynMINOS11_RS01755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMINOS11_RS01770	COG0439	Biotin carboxylase
SynMINOS11_RS01785	COG0515	serine threonine protein kinase
SynMINOS11_RS01800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_RS01805	COG4178	(ABC) transporter
SynMINOS11_RS01810	COG0537	adenosine 5'-monophosphoramidase activity
SynMINOS11_RS01835	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynMINOS11_RS01850	COG0242	peptide deformylase activity
SynMINOS11_RS01860	COG2988	succinylglutamate desuccinylase activity
SynMINOS11_RS01940	COG1570	exodeoxyribonuclease VII activity
SynMINOS11_RS01950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_RS01975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMINOS11_RS01995	COG0488	(ABC) transporter
SynMINOS11_RS02025	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynMINOS11_RS02030	COG0450	alkyl hydroperoxide reductase
SynMINOS11_RS02035	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_RS02040	COG0546	phosphoglycolate phosphatase activity
SynMINOS11_RS02045	COG1252	NADH dehydrogenase
SynMINOS11_RS02050	COG0175	sulfate reduction
SynMINOS11_RS02055	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynMINOS11_RS02060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMINOS11_RS02090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMINOS11_RS02095	COG0033	Phosphoglucomutase
SynMINOS11_RS02110	COG3394	polysaccharide catabolic process
SynMINOS11_RS02115	COG0463	Glycosyl transferase, family 2
SynMINOS11_RS02125	COG0659	secondary active sulfate transmembrane transporter activity
SynMINOS11_RS02130	COG0418	dihydroorotase activity
SynMINOS11_RS02145	COG1070	Carbohydrate kinase
SynMINOS11_RS02150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynMINOS11_RS02160	COG0539	negative regulation of cytoplasmic translation
SynMINOS11_RS02165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynMINOS11_RS02190	COG0589	response to stress
SynMINOS11_RS02195	COG0824	Thioesterase
SynMINOS11_RS02200	COG0758	DNA mediated transformation
SynMINOS11_RS02200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynMINOS11_RS02205	COG2890	protein-(glutamine-N5) methyltransferase activity
SynMINOS11_RS02210	COG0009	L-threonylcarbamoyladenylate synthase
SynMINOS11_RS02215	COG0798	PFAM Bile acid sodium symporter
SynMINOS11_RS02225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynMINOS11_RS02230	COG0640	Transcriptional regulator
SynMINOS11_RS02240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_RS02265	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynMINOS11_RS02270	COG2894	cell division
SynMINOS11_RS02275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SynMINOS11_RS02290	COG0850	regulation of cytokinetic process
SynMINOS11_RS02295	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
SynMINOS11_RS02300	COG1078	dGTPase activity
SynMINOS11_RS02305	COG0793	Belongs to the peptidase S41A family
SynMINOS11_RS02310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynMINOS11_RS02315	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynMINOS11_RS02325	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynMINOS11_RS02330	COG0235	Class ii aldolase
SynMINOS11_RS02335	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynMINOS11_RS02350	COG0514	ATP-dependent DNA helicase (RecQ)
SynMINOS11_RS02355	COG1012	belongs to the aldehyde dehydrogenase family
SynMINOS11_RS02370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynMINOS11_RS02385	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynMINOS11_RS02400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynMINOS11_RS02415	COG1376	ErfK ybiS ycfS ynhG family protein
SynMINOS11_RS02420	COG1160	GTP binding
SynMINOS11_RS02425	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynMINOS11_RS02435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynMINOS11_RS02440	COG1799	cell septum assembly
SynMINOS11_RS02445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynMINOS11_RS02450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynMINOS11_RS02465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynMINOS11_RS02470	COG2211	Major facilitator Superfamily
SynMINOS11_RS02490	COG0776	regulation of translation
SynMINOS11_RS02520	COG2274	protein secretion by the type I secretion system
SynMINOS11_RS02525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SynMINOS11_RS02660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_RS02755	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynMINOS11_RS02760	COG1218	3'(2'),5'-bisphosphate nucleotidase
SynMINOS11_RS02765	COG1185	polyribonucleotide nucleotidyltransferase activity
SynMINOS11_RS02770	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SynMINOS11_RS02775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynMINOS11_RS02780	COG0750	zinc metalloprotease
SynMINOS11_RS02785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynMINOS11_RS02790	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynMINOS11_RS02795	COG0579	oxidoreductase
SynMINOS11_RS02805	COG0371	Dehydrogenase
SynMINOS11_RS02810	COG0481	GTPase activity
SynMINOS11_RS02865	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_RS02875	COG2205	protein histidine kinase activity
SynMINOS11_RS02890	COG5002	protein histidine kinase activity
SynMINOS11_RS02895	COG1450	Type ii and iii secretion system protein
SynMINOS11_RS02925	COG4968	Prepilin-type N-terminal cleavage methylation domain
SynMINOS11_RS02930	COG4968	Prepilin-type N-terminal cleavage methylation domain
SynMINOS11_RS02960	COG4968	Prepilin-type N-terminal cleavage methylation domain
SynMINOS11_RS02980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMINOS11_RS02990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynMINOS11_RS02990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynMINOS11_RS03000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynMINOS11_RS03005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynMINOS11_RS03015	COG0107	imidazoleglycerol-phosphate synthase activity
SynMINOS11_RS03025	COG2226	methyltransferase
SynMINOS11_RS03035	COG2132	Multicopper oxidase
SynMINOS11_RS03045	COG0752	glycyl-tRNA synthetase alpha subunit
SynMINOS11_RS03075	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_RS03120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynMINOS11_RS03125	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynMINOS11_RS03130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynMINOS11_RS03135	COG0740	serine-type endopeptidase activity
SynMINOS11_RS03140	COG0740	serine-type endopeptidase activity
SynMINOS11_RS03145	COG4956	integral membrane protein (PIN domain superfamily)
SynMINOS11_RS03150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynMINOS11_RS03155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynMINOS11_RS03165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynMINOS11_RS03180	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynMINOS11_RS03185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynMINOS11_RS03190	COG4948	Mandelate Racemase Muconate Lactonizing
SynMINOS11_RS03225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynMINOS11_RS03230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynMINOS11_RS03235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynMINOS11_RS03250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMINOS11_RS03255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynMINOS11_RS03260	COG0134	indole-3-glycerol-phosphate synthase activity
SynMINOS11_RS03295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynMINOS11_RS03300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynMINOS11_RS03310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynMINOS11_RS03315	COG1104	cysteine desulfurase activity
SynMINOS11_RS03370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMINOS11_RS03380	COG0706	membrane insertase activity
SynMINOS11_RS03390	COG0594	ribonuclease P activity
SynMINOS11_RS03395	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynMINOS11_RS03415	COG0616	signal peptide processing
SynMINOS11_RS03420	COG0697	spore germination
SynMINOS11_RS03425	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_RS03435	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynMINOS11_RS03440	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynMINOS11_RS03440	COG0662	Cupin 2, conserved barrel domain protein
SynMINOS11_RS03445	COG3273	potassium ion transport
SynMINOS11_RS03445	COG0471	metal ion transport
SynMINOS11_RS03455	COG1842	Phage shock protein A
SynMINOS11_RS03460	COG3118	belongs to the thioredoxin family
SynMINOS11_RS03465	COG0436	Aminotransferase
SynMINOS11_RS03480	COG0739	heme binding
SynMINOS11_RS03485	COG0577	efflux transmembrane transporter activity
SynMINOS11_RS03485	COG1136	(ABC) transporter
SynMINOS11_RS03490	COG1007	ATP synthesis coupled electron transport
SynMINOS11_RS03495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynMINOS11_RS03510	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynMINOS11_RS03545	COG1845	cytochrome c oxidase, subunit III
SynMINOS11_RS03550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynMINOS11_RS03565	COG0109	protoheme IX farnesyltransferase activity
SynMINOS11_RS03585	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynMINOS11_RS03600	COG1028	Short-chain dehydrogenase reductase Sdr
SynMINOS11_RS03615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynMINOS11_RS03620	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynMINOS11_RS03625	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynMINOS11_RS03650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynMINOS11_RS03655	COG3258	Cytochrome c
SynMINOS11_RS03660	COG0723	plastoquinol--plastocyanin reductase activity
SynMINOS11_RS03670	COG0805	protein transport
SynMINOS11_RS03680	COG0194	GDP metabolic process
SynMINOS11_RS03700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_RS03715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynMINOS11_RS03720	COG0012	GTP binding
SynMINOS11_RS03740	COG0601	transmembrane transport
SynMINOS11_RS03755	COG0460	homoserine dehydrogenase
SynMINOS11_RS03760	COG2166	iron-sulfur cluster assembly
SynMINOS11_RS03775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynMINOS11_RS03780	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynMINOS11_RS03785	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMINOS11_RS03805	COG2010	Cytochrome c
SynMINOS11_RS03820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynMINOS11_RS03825	COG1611	Belongs to the LOG family
SynMINOS11_RS03830	COG3118	belongs to the thioredoxin family
SynMINOS11_RS03835	COG0516	GMP reductase activity
SynMINOS11_RS03840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynMINOS11_RS03850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynMINOS11_RS03855	COG0644	oxidoreductase
SynMINOS11_RS03865	COG1543	Belongs to the glycosyl hydrolase 57 family
SynMINOS11_RS03870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynMINOS11_RS03875	COG0395	ABC-type sugar transport system, permease component
SynMINOS11_RS03880	COG1480	7TM receptor with intracellular HD hydrolase
SynMINOS11_RS03885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynMINOS11_RS03920	COG1254	Belongs to the acylphosphatase family
SynMINOS11_RS03925	COG1797	cobyrinic acid a,c-diamide synthase activity
SynMINOS11_RS03930	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynMINOS11_RS03930	COG3409	Peptidoglycan-binding domain 1 protein
SynMINOS11_RS03935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynMINOS11_RS03955	COG2205	protein histidine kinase activity
SynMINOS11_RS03980	COG0308	aminopeptidase N
SynMINOS11_RS04000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynMINOS11_RS04015	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SynMINOS11_RS04020	COG1640	4-alpha-glucanotransferase
SynMINOS11_RS04030	COG1187	pseudouridine synthase activity
SynMINOS11_RS04035	COG5002	protein histidine kinase activity
SynMINOS11_RS04040	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_RS04050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMINOS11_RS04055	COG1982	Orn Lys Arg decarboxylase major
SynMINOS11_RS04060	COG2241	protein methyltransferase activity
SynMINOS11_RS04060	COG2242	protein methyltransferase activity
SynMINOS11_RS04065	COG0575	Belongs to the CDS family
SynMINOS11_RS04080	COG0371	Dehydrogenase
SynMINOS11_RS04085	COG0542	response to heat
SynMINOS11_RS04095	COG0019	diaminopimelate decarboxylase activity
SynMINOS11_RS04105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynMINOS11_RS04110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynMINOS11_RS04115	COG1054	Belongs to the UPF0176 family
SynMINOS11_RS04125	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynMINOS11_RS04140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynMINOS11_RS04145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynMINOS11_RS04150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynMINOS11_RS04215	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMINOS11_RS04220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynMINOS11_RS04235	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMINOS11_RS04240	COG1850	ribulose-bisphosphate carboxylase activity
SynMINOS11_RS04245	COG4451	ribulose bisphosphate carboxylase, small
SynMINOS11_RS04270	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMINOS11_RS04280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynMINOS11_RS04285	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_RS04300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynMINOS11_RS04305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMINOS11_RS04320	COG0456	acetyltransferase
SynMINOS11_RS04330	COG1132	(ABC) transporter
SynMINOS11_RS04335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynMINOS11_RS04340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynMINOS11_RS04345	COG0251	oxidation-reduction process
SynMINOS11_RS04355	COG0488	(ABC) transporter
SynMINOS11_RS04390	COG2326	polyphosphate kinase activity
SynMINOS11_RS04405	COG0028	Belongs to the TPP enzyme family
SynMINOS11_RS04410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_RS04420	COG2226	methyltransferase
SynMINOS11_RS04435	COG0528	UMP kinase activity
SynMINOS11_RS04440	COG0233	cytoplasmic translational termination
SynMINOS11_RS04455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynMINOS11_RS04460	COG0768	penicillin binding
SynMINOS11_RS04475	COG0588	phosphoglycerate mutase activity
SynMINOS11_RS04480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SynMINOS11_RS04505	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynMINOS11_RS04520	COG0442	prolyl-tRNA aminoacylation
SynMINOS11_RS04535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynMINOS11_RS04540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynMINOS11_RS04545	COG1324	tolerance protein
SynMINOS11_RS04570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynMINOS11_RS04580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynMINOS11_RS04585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_RS04605	COG0181	hydroxymethylbilane synthase activity
SynMINOS11_RS04610	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynMINOS11_RS04625	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynMINOS11_RS04655	COG0542	response to heat
SynMINOS11_RS04670	COG2010	Cytochrome c
SynMINOS11_RS04680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynMINOS11_RS04685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynMINOS11_RS04715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynMINOS11_RS04720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SynMINOS11_RS04780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SynMINOS11_RS04785	COG0011	TIGRFAM Protein of
SynMINOS11_RS04790	COG0339	signal peptide processing
SynMINOS11_RS04795	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_RS04800	COG0083	homoserine kinase activity
SynMINOS11_RS04805	COG0837	glucose binding
SynMINOS11_RS04810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynMINOS11_RS04840	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynMINOS11_RS04855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynMINOS11_RS04920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynMINOS11_RS04935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_RS04940	COG1429	ligase activity, forming nitrogen-metal bonds
SynMINOS11_RS04945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynMINOS11_RS04955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynMINOS11_RS04960	COG0149	triose-phosphate isomerase activity
SynMINOS11_RS04970	COG1132	(ABC) transporter
SynMINOS11_RS04980	COG1115	amino acid carrier protein
SynMINOS11_RS04990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynMINOS11_RS05025	COG1970	mechanosensitive ion channel activity
SynMINOS11_RS05050	COG0673	inositol 2-dehydrogenase activity
SynMINOS11_RS05060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynMINOS11_RS05065	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynMINOS11_RS05075	COG3954	Phosphoribulokinase
SynMINOS11_RS05080	COG0473	3-isopropylmalate dehydrogenase activity
SynMINOS11_RS05085	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMINOS11_RS05090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynMINOS11_RS05105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynMINOS11_RS05135	COG2197	response regulator
SynMINOS11_RS05145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynMINOS11_RS05155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SynMINOS11_RS05180	COG1201	RNA secondary structure unwinding
SynMINOS11_RS05185	COG1793	dna ligase
SynMINOS11_RS05205	COG0598	Magnesium transport protein CorA
SynMINOS11_RS05320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynMINOS11_RS05345	COG0659	secondary active sulfate transmembrane transporter activity
SynMINOS11_RS05350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynMINOS11_RS05350	COG0426	domain, Protein
SynMINOS11_RS05500	COG0724	RNA recognition motif
SynMINOS11_RS05610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SynMINOS11_RS05615	COG0732	type I restriction modification DNA specificity domain
SynMINOS11_RS05620	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SynMINOS11_RS05640	COG2124	cytochrome p450
SynMINOS11_RS05670	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynMINOS11_RS05705	COG5002	protein histidine kinase activity
SynMINOS11_RS05725	COG0367	asparagine synthase
SynMINOS11_RS05730	COG0540	Belongs to the ATCase OTCase family
SynMINOS11_RS05750	COG1773	rubredoxin
SynMINOS11_RS05800	COG0681	Belongs to the peptidase S26 family
SynMINOS11_RS05805	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynMINOS11_RS05820	COG1376	ErfK ybiS ycfS ynhG family protein
SynMINOS11_RS05825	COG0297	glycogen (starch) synthase activity
SynMINOS11_RS05835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynMINOS11_RS05840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynMINOS11_RS05850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynMINOS11_RS05870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynMINOS11_RS05875	COG2045	Belongs to the ComB family
SynMINOS11_RS05890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynMINOS11_RS05895	COG0142	geranyltranstransferase activity
SynMINOS11_RS05960	COG4106	trans-aconitate 2-methyltransferase activity
SynMINOS11_RS05965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynMINOS11_RS05985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SynMINOS11_RS06010	COG0415	Belongs to the DNA photolyase family
SynMINOS11_RS06025	COG0495	leucyl-tRNA aminoacylation
SynMINOS11_RS06035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynMINOS11_RS06040	COG1104	cysteine desulfurase activity
SynMINOS11_RS06065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynMINOS11_RS06070	COG0322	excinuclease ABC activity
SynMINOS11_RS06090	COG2197	response regulator
SynMINOS11_RS06095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynMINOS11_RS06100	COG3046	protein related to deoxyribodipyrimidine photolyase
SynMINOS11_RS06105	COG1981	membrane
SynMINOS11_RS06110	COG0587	DNA-directed DNA polymerase activity
SynMINOS11_RS06125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynMINOS11_RS06130	COG0646	methionine synthase
SynMINOS11_RS06130	COG1410	methionine synthase
SynMINOS11_RS06155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SynMINOS11_RS06165	COG2385	sporulation resulting in formation of a cellular spore
SynMINOS11_RS06195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynMINOS11_RS06200	COG0072	phenylalanine-tRNA ligase activity
SynMINOS11_RS06205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynMINOS11_RS06210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynMINOS11_RS06215	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
SynMINOS11_RS06225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynMINOS11_RS06260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynMINOS11_RS06265	COG0739	heme binding
SynMINOS11_RS06280	COG0450	alkyl hydroperoxide reductase
SynMINOS11_RS06285	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynMINOS11_RS06290	COG0047	phosphoribosylformylglycinamidine synthase activity
SynMINOS11_RS06320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynMINOS11_RS06330	COG0129	dihydroxy-acid dehydratase activity
SynMINOS11_RS06345	COG0363	glucosamine-6-phosphate deaminase activity
SynMINOS11_RS06350	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynMINOS11_RS06355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMINOS11_RS06360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynMINOS11_RS06365	COG1494	fructose-1,6-bisphosphatase
SynMINOS11_RS06370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynMINOS11_RS06385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynMINOS11_RS06395	COG1137	ATPase activity
SynMINOS11_RS06410	COG1217	gtp-binding protein TYPA
SynMINOS11_RS06420	COG0644	oxidoreductase
SynMINOS11_RS06425	COG0751	glycine-tRNA ligase activity
SynMINOS11_RS06430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynMINOS11_RS06435	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynMINOS11_RS06440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynMINOS11_RS06450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynMINOS11_RS06455	COG0052	Belongs to the universal ribosomal protein uS2 family
SynMINOS11_RS06460	COG1216	Glycosyl transferase, family 2
SynMINOS11_RS06475	COG0811	peptide transport
SynMINOS11_RS06485	COG1136	(ABC) transporter
SynMINOS11_RS06505	COG0612	Peptidase, M16
SynMINOS11_RS06525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynMINOS11_RS06530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynMINOS11_RS06540	COG0076	glutamate decarboxylase activity
SynMINOS11_RS06550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynMINOS11_RS06560	COG0174	glutamine synthetase
SynMINOS11_RS06590	COG0515	serine threonine protein kinase
SynMINOS11_RS06595	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynMINOS11_RS06600	COG3310	Protein conserved in bacteria
SynMINOS11_RS06605	COG0628	permease
SynMINOS11_RS06630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynMINOS11_RS06635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynMINOS11_RS06640	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynMINOS11_RS06640	COG0022	dehydrogenase e1 component
SynMINOS11_RS06650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynMINOS11_RS06655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynMINOS11_RS06660	COG0792	nuclease activity
SynMINOS11_RS06675	COG0358	DNA primase activity
SynMINOS11_RS06690	COG0632	four-way junction helicase activity
SynMINOS11_RS06695	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynMINOS11_RS06705	COG0587	DNA-directed DNA polymerase activity
SynMINOS11_RS06710	COG0154	amidase activity
SynMINOS11_RS06720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMINOS11_RS06725	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynMINOS11_RS06735	COG0505	Belongs to the CarA family
SynMINOS11_RS06740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynMINOS11_RS06750	COG1132	(ABC) transporter
SynMINOS11_RS06760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMINOS11_RS06780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynMINOS11_RS06790	COG2176	DNA-directed DNA polymerase activity
SynMINOS11_RS06795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMINOS11_RS06805	COG0530	calcium, potassium:sodium antiporter activity
SynMINOS11_RS06810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynMINOS11_RS06815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynMINOS11_RS06820	COG2271	Major facilitator Superfamily
SynMINOS11_RS06825	COG0166	Belongs to the GPI family
SynMINOS11_RS06850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynMINOS11_RS06855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynMINOS11_RS06860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynMINOS11_RS06860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynMINOS11_RS06865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMINOS11_RS06870	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynMINOS11_RS06875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynMINOS11_RS06885	COG0484	heat shock protein binding
SynMINOS11_RS06890	COG0443	Heat shock 70 kDa protein
SynMINOS11_RS06895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMINOS11_RS06900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMINOS11_RS06905	COG0573	inorganic phosphate transmembrane transporter activity
SynMINOS11_RS06910	COG0581	inorganic phosphate transmembrane transporter activity
SynMINOS11_RS06915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynMINOS11_RS06920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMINOS11_RS06930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynMINOS11_RS06935	COG0483	inositol monophosphate 1-phosphatase activity
SynMINOS11_RS06940	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynMINOS11_RS06950	COG0326	Molecular chaperone. Has ATPase activity
SynMINOS11_RS06960	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynMINOS11_RS06965	COG1653	transport
SynMINOS11_RS06980	COG3842	ATPase activity
SynMINOS11_RS06995	COG0366	Alpha amylase catalytic
SynMINOS11_RS07000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynMINOS11_RS07005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynMINOS11_RS07010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynMINOS11_RS07015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMINOS11_RS07045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynMINOS11_RS07050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynMINOS11_RS07085	COG0469	pyruvate kinase activity
SynMINOS11_RS07090	COG0577	efflux transmembrane transporter activity
SynMINOS11_RS07090	COG1136	(ABC) transporter
SynMINOS11_RS07100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMINOS11_RS07110	COG0740	serine-type endopeptidase activity
SynMINOS11_RS07130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynMINOS11_RS07175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynMINOS11_RS07180	COG1175	transmembrane transport
SynMINOS11_RS07185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynMINOS11_RS07190	COG2226	methyltransferase
SynMINOS11_RS07200	COG1942	4-Oxalocrotonate Tautomerase
SynMINOS11_RS07255	COG2197	response regulator
SynMINOS11_RS07260	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynMINOS11_RS07280	COG0475	glutathione-regulated potassium exporter activity
SynMINOS11_RS07315	COG0180	Tryptophanyl-tRNA synthetase
SynMINOS11_RS07325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynMINOS11_RS07330	COG1122	ATPase activity
SynMINOS11_RS07355	COG1836	PFAM Integral membrane protein DUF92
SynMINOS11_RS07360	COG1191	sigma factor activity
SynMINOS11_RS07365	COG3639	organic phosphonate transmembrane transporter activity
SynMINOS11_RS07370	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynMINOS11_RS07375	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynMINOS11_RS07380	COG0436	Aminotransferase
SynMINOS11_RS07390	COG1573	uracil-dna glycosylase
SynMINOS11_RS07400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynMINOS11_RS07405	COG0793	Belongs to the peptidase S41A family
SynMINOS11_RS07415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynMINOS11_RS07445	COG0861	Integral membrane protein TerC family
SynMINOS11_RS07455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynMINOS11_RS07465	COG0312	modulator of DNA gyrase
SynMINOS11_RS07470	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynMINOS11_RS07485	COG0163	prenyltransferase activity
SynMINOS11_RS07490	COG0557	exoribonuclease II activity
SynMINOS11_RS07500	COG2119	membrane
SynMINOS11_RS07520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynMINOS11_RS07520	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynMINOS11_RS07525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynMINOS11_RS07535	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynMINOS11_RS07540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMINOS11_RS07545	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SynMINOS11_RS07550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SynMINOS11_RS07560	COG0191	fructose-bisphosphate aldolase activity
SynMINOS11_RS07580	COG0435	Glutathione S-transferase
SynMINOS11_RS07615	COG0432	Pfam Uncharacterised protein family UPF0047
SynMINOS11_RS07630	COG3179	chitinase
SynMINOS11_RS07650	COG0477	Major facilitator Superfamily
SynMINOS11_RS07660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMINOS11_RS07705	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_RS07810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynMINOS11_RS07815	COG1233	COG1233 Phytoene dehydrogenase and related
SynMINOS11_RS07820	COG2095	MarC family integral membrane protein
SynMINOS11_RS07825	COG0076	glutamate decarboxylase activity
SynMINOS11_RS07850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynMINOS11_RS07855	COG0271	Belongs to the BolA IbaG family
SynMINOS11_RS07870	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynMINOS11_RS07880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynMINOS11_RS07885	COG1074	ATP-dependent DNA helicase activity
SynMINOS11_RS07890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynMINOS11_RS07905	COG0513	Belongs to the DEAD box helicase family
SynMINOS11_RS07920	COG1316	TRANSCRIPTIONal
SynMINOS11_RS07925	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynMINOS11_RS07930	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynMINOS11_RS07935	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynMINOS11_RS07950	COG1741	Belongs to the pirin family
SynMINOS11_RS07955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynMINOS11_RS07960	COG0569	domain protein
SynMINOS11_RS07980	COG0704	Plays a role in the regulation of phosphate uptake
SynMINOS11_RS07995	COG0095	Lipoate-protein ligase
SynMINOS11_RS08000	COG1994	Peptidase M50
SynMINOS11_RS08000	COG0517	IMP dehydrogenase activity
SynMINOS11_RS08005	COG0135	phosphoribosylanthranilate isomerase activity
SynMINOS11_RS08015	COG0302	gtp cyclohydrolase
SynMINOS11_RS08020	COG0300	oxidoreductase activity
SynMINOS11_RS08030	COG5322	oxidoreductase activity
SynMINOS11_RS08035	COG3396	Phenylacetate-CoA oxygenase
SynMINOS11_RS08045	COG0539	negative regulation of cytoplasmic translation
SynMINOS11_RS08055	COG1496	oxidoreductase activity
SynMINOS11_RS08095	COG2010	Cytochrome c
SynMINOS11_RS08105	COG0159	tryptophan synthase activity
SynMINOS11_RS08155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_RS08165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynMINOS11_RS08170	COG1121	(ABC) transporter
SynMINOS11_RS08175	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynMINOS11_RS08180	COG0701	Predicted permease
SynMINOS11_RS08195	COG0140	phosphoribosyl-ATP diphosphatase activity
SynMINOS11_RS08195	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynMINOS11_RS08200	COG0720	synthase
SynMINOS11_RS08235	COG0789	Transcriptional regulator
SynMINOS11_RS08240	COG0523	cobalamin synthesis protein
SynMINOS11_RS08255	COG1840	ABC-type Fe3 transport system, periplasmic component
SynMINOS11_RS08265	COG3842	ATPase activity
SynMINOS11_RS08270	COG0735	belongs to the Fur family
SynMINOS11_RS08300	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynMINOS11_RS08330	COG0277	FAD linked oxidase domain protein
SynMINOS11_RS08335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynMINOS11_RS08340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SynMINOS11_RS08355	COG0405	Gamma-glutamyltransferase
SynMINOS11_RS08380	COG1666	GTP binding
SynMINOS11_RS08395	COG0857	belongs to the CobB CobQ family
SynMINOS11_RS08400	COG0300	oxidoreductase activity
SynMINOS11_RS08400	COG3000	fatty acid hydroxylase
SynMINOS11_RS08405	COG0024	Methionine aminopeptidase
SynMINOS11_RS08415	COG0335	large ribosomal subunit rRNA binding
SynMINOS11_RS08435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynMINOS11_RS08440	COG0025	NhaP-type Na H and K H
SynMINOS11_RS08450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynMINOS11_RS08450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynMINOS11_RS08455	COG0215	cysteine-tRNA ligase activity
SynMINOS11_RS08470	COG0733	neurotransmitter:sodium symporter activity
SynMINOS11_RS08475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynMINOS11_RS08515	COG0492	ferredoxin-NADP+ reductase activity
SynMINOS11_RS08520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynMINOS11_RS08525	COG1187	pseudouridine synthase activity
SynMINOS11_RS08555	COG0440	acetolactate synthase activity
SynMINOS11_RS08560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMINOS11_RS08615	COG0424	maF-like protein
SynMINOS11_RS08625	COG1492	cobalamin metabolic process
SynMINOS11_RS08640	COG0482	sulfurtransferase activity
SynMINOS11_RS08645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynMINOS11_RS08645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynMINOS11_RS08650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_RS08655	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynMINOS11_RS08660	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynMINOS11_RS08670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynMINOS11_RS08675	COG0228	four-way junction DNA binding
SynMINOS11_RS08680	COG1702	phosphate starvation-inducible protein PhoH
SynMINOS11_RS08710	COG3527	Alpha-acetolactate decarboxylase
SynMINOS11_RS08715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynMINOS11_RS08725	COG0336	Belongs to the RNA methyltransferase TrmD family
SynMINOS11_RS08730	COG0330	HflC and HflK could
SynMINOS11_RS08740	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynMINOS11_RS08755	COG1691	(AIR) carboxylase
SynMINOS11_RS08775	COG0352	thiamine-phosphate diphosphorylase activity
SynMINOS11_RS08785	COG0196	riboflavin kinase activity
SynMINOS11_RS08795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynMINOS11_RS08800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynMINOS11_RS08805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMINOS11_RS08810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynMINOS11_RS08815	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_RS08850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynMINOS11_RS08850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynMINOS11_RS08865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMINOS11_RS08875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynMINOS11_RS08880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynMINOS11_RS08890	COG3239	Fatty acid desaturase
SynMINOS11_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
SynMINOS11_RS08990	COG2105	PFAM AIG2 family protein
SynMINOS11_RS09020	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynMINOS11_RS09025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMINOS11_RS09040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynMINOS11_RS09045	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynMINOS11_RS09050	COG0531	amino acid
SynMINOS11_RS09065	COG1022	Amp-dependent synthetase and ligase
SynMINOS11_RS09070	COG0321	lipoyl(octanoyl) transferase activity
SynMINOS11_RS09075	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynMINOS11_RS09080	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynMINOS11_RS09095	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_RS09100	COG0284	orotidine-5'-phosphate decarboxylase activity
SynMINOS11_RS09110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynMINOS11_RS09130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynMINOS11_RS09140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_RS09155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMINOS11_RS09160	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMINOS11_RS09165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMINOS11_RS09170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynMINOS11_RS09175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynMINOS11_RS09185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynMINOS11_RS09195	COG0151	Belongs to the GarS family
SynMINOS11_RS09200	COG5002	protein histidine kinase activity
SynMINOS11_RS09205	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynMINOS11_RS09210	COG4251	negative regulation of phosphorylation
SynMINOS11_RS09220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynMINOS11_RS09225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynMINOS11_RS09240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynMINOS11_RS09250	COG0217	transcriptional regulatory protein
SynMINOS11_RS09260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynMINOS11_RS09270	COG0363	glucosamine-6-phosphate deaminase activity
SynMINOS11_RS09275	COG2247	cell wall binding repeat
SynMINOS11_RS09275	COG2385	sporulation resulting in formation of a cellular spore
SynMINOS11_RS09280	COG1234	tRNA 3'-trailer cleavage
SynMINOS11_RS09285	COG2010	Cytochrome c
SynMINOS11_RS09300	COG2264	protein methyltransferase activity
SynMINOS11_RS09305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynMINOS11_RS09325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynMINOS11_RS09355	COG1077	Cell shape determining protein MreB Mrl
SynMINOS11_RS09370	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynMINOS11_RS09385	COG0459	protein refolding
SynMINOS11_RS09390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynMINOS11_RS09395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynMINOS11_RS09400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynMINOS11_RS09415	COG0387	Pfam Sodium calcium exchanger
SynMINOS11_RS09420	COG0006	proline dipeptidase activity
SynMINOS11_RS09425	COG1253	flavin adenine dinucleotide binding
SynMINOS11_RS09430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynMINOS11_RS09435	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynMINOS11_RS09440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynMINOS11_RS09440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynMINOS11_RS09455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynMINOS11_RS09465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynMINOS11_RS09475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynMINOS11_RS09480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynMINOS11_RS09485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynMINOS11_RS09490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynMINOS11_RS09495	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynMINOS11_RS09500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynMINOS11_RS09505	COG0356	it plays a direct role in the translocation of protons across the membrane
SynMINOS11_RS09515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynMINOS11_RS09520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMINOS11_RS09540	COG0772	Belongs to the SEDS family
SynMINOS11_RS09555	COG1333	cytochrome c biogenesis protein
SynMINOS11_RS09560	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynMINOS11_RS09565	COG0347	Belongs to the P(II) protein family
SynMINOS11_RS09580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynMINOS11_RS09670	COG4581	dead DEAH box helicase
SynMINOS11_RS09675	COG0156	8-amino-7-oxononanoate synthase activity
SynMINOS11_RS09680	COG1381	Involved in DNA repair and RecF pathway recombination
SynMINOS11_RS09685	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynMINOS11_RS09685	COG4106	trans-aconitate 2-methyltransferase activity
SynMINOS11_RS09690	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynMINOS11_RS09735	COG2010	Cytochrome c
SynMINOS11_RS09735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynMINOS11_RS09750	COG0114	fumarate hydratase activity
SynMINOS11_RS09755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynMINOS11_RS09780	COG0484	heat shock protein binding
SynMINOS11_RS09785	COG0357	Ribosomal RNA small subunit methyltransferase G
SynMINOS11_RS09815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SynMINOS11_RS09820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynMINOS11_RS09830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynMINOS11_RS09835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynMINOS11_RS09840	COG0085	RNA polymerase activity
SynMINOS11_RS09845	COG0084	hydrolase, TatD family'
SynMINOS11_RS09850	COG0268	Binds directly to 16S ribosomal RNA
SynMINOS11_RS09855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynMINOS11_RS09865	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynMINOS11_RS09870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMINOS11_RS09880	COG0779	Required for maturation of 30S ribosomal subunits
SynMINOS11_RS09885	COG0195	Participates in both transcription termination and antitermination
SynMINOS11_RS09895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynMINOS11_RS09985	COG1012	belongs to the aldehyde dehydrogenase family
SynMINOS11_RS10050	COG0463	Glycosyl transferase, family 2
SynMINOS11_RS10055	COG0366	Alpha amylase catalytic
SynMINOS11_RS10060	COG3769	mannosylglycerate metabolic process
SynMINOS11_RS10070	COG0235	Class ii aldolase
SynMINOS11_RS10080	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynMINOS11_RS10095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynMINOS11_RS10100	COG0719	Fe-S assembly protein
SynMINOS11_RS10105	COG0396	ATPase activity
SynMINOS11_RS10110	COG0719	Fe-S assembly protein
SynMINOS11_RS10115	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynMINOS11_RS10120	COG1830	Aldolase
SynMINOS11_RS10145	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMINOS11_RS10160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynMINOS11_RS10170	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynMINOS11_RS10170	COG3264	Mechanosensitive ion channel
SynMINOS11_RS10200	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMINOS11_RS10375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynMINOS11_RS10380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynMINOS11_RS10380	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynMINOS11_RS10385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynMINOS11_RS10390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynMINOS11_RS10435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynMINOS11_RS10455	COG0408	coproporphyrinogen oxidase activity
SynMINOS11_RS10460	COG0489	protein tyrosine kinase activity
SynMINOS11_RS10465	COG0772	Belongs to the SEDS family
SynMINOS11_RS10480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynMINOS11_RS10485	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynMINOS11_RS10490	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynMINOS11_RS10505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynMINOS11_RS10515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynMINOS11_RS10520	COG1606	tRNA processing
SynMINOS11_RS10535	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynMINOS11_RS10550	COG1132	(ABC) transporter
SynMINOS11_RS10570	COG3001	Fructosamine kinase
SynMINOS11_RS10580	COG0287	Prephenate dehydrogenase
SynMINOS11_RS10600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynMINOS11_RS10615	COG3854	ATPases associated with a variety of cellular activities
SynMINOS11_RS10630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynMINOS11_RS10635	COG0088	Forms part of the polypeptide exit tunnel
SynMINOS11_RS10640	COG0089	rRNA binding
SynMINOS11_RS10645	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynMINOS11_RS10650	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynMINOS11_RS10655	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynMINOS11_RS10660	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynMINOS11_RS10665	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynMINOS11_RS10670	COG0255	Belongs to the universal ribosomal protein uL29 family
SynMINOS11_RS10675	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynMINOS11_RS10680	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynMINOS11_RS10685	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynMINOS11_RS10690	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynMINOS11_RS10695	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynMINOS11_RS10700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynMINOS11_RS10705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynMINOS11_RS10710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynMINOS11_RS10715	COG0200	Binds to the 23S rRNA
SynMINOS11_RS10720	COG0201	protein transport
SynMINOS11_RS10725	COG0563	adenylate kinase activity
SynMINOS11_RS10730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynMINOS11_RS10735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynMINOS11_RS10740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynMINOS11_RS10745	COG0202	RNA polymerase activity
SynMINOS11_RS10750	COG0203	ribosomal protein L17
SynMINOS11_RS10755	COG0101	tRNA pseudouridine synthase activity
SynMINOS11_RS10760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynMINOS11_RS10765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynMINOS11_RS10770	COG0254	rRNA binding
SynMINOS11_RS10775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynMINOS11_RS10785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynMINOS11_RS10805	COG0791	NLP P60 protein
SynMINOS11_RS10810	COG0463	Glycosyl transferase, family 2
SynMINOS11_RS10840	COG2885	chlorophyll binding
SynMINOS11_RS10845	COG2885	chlorophyll binding
SynMINOS11_RS10870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynMINOS11_RS10875	COG0659	secondary active sulfate transmembrane transporter activity
SynMINOS11_RS10880	COG0067	glutamate synthase
SynMINOS11_RS10880	COG0069	glutamate synthase activity
SynMINOS11_RS10880	COG0070	glutamate synthase
SynMINOS11_RS10895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynMINOS11_RS10900	COG0049	tRNA binding
SynMINOS11_RS10905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynMINOS11_RS10910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynMINOS11_RS10915	COG0051	transcription antitermination factor activity, RNA binding
SynMINOS11_RS10925	COG2226	methyltransferase
SynMINOS11_RS10930	COG0077	Prephenate dehydratase
SynMINOS11_RS10940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynMINOS11_RS10945	COG1530	ribonuclease E activity
SynMINOS11_RS10950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynMINOS11_RS10955	COG0436	Aminotransferase
SynMINOS11_RS10960	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynMINOS11_RS10990	COG1121	(ABC) transporter
SynMINOS11_RS10995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynMINOS11_RS11000	COG3386	PFAM SMP-30 Gluconolaconase
SynMINOS11_RS11005	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynMINOS11_RS11020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMINOS11_RS11025	COG2046	Belongs to the sulfate adenylyltransferase family
SynMINOS11_RS11025	COG0529	Catalyzes the synthesis of activated sulfate
SynMINOS11_RS11040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynMINOS11_RS11045	COG3536	Protein conserved in bacteria
SynMINOS11_RS11080	COG0540	Belongs to the ATCase OTCase family
SynMINOS11_RS11085	COG2094	Belongs to the DNA glycosylase MPG family
SynMINOS11_RS11095	COG1402	creatininase
SynMINOS11_RS11100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynMINOS11_RS11125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynMINOS11_RS11145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynMINOS11_RS11160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynMINOS11_RS11170	COG0741	lytic transglycosylase activity
SynMINOS11_RS11185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynMINOS11_RS11190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynMINOS11_RS11210	COG0126	phosphoglycerate kinase activity
SynMINOS11_RS11215	COG0589	response to stress
SynMINOS11_RS11220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynMINOS11_RS11225	COG0564	pseudouridine synthase activity
SynMINOS11_RS11240	COG4172	Belongs to the ABC transporter superfamily
SynMINOS11_RS11245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynMINOS11_RS11260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynMINOS11_RS11270	COG0157	Belongs to the NadC ModD family
SynMINOS11_RS11275	COG0018	arginyl-trna synthetase
SynMINOS11_RS11280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynMINOS11_RS11305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynMINOS11_RS11310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynMINOS11_RS11325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynMINOS11_RS11330	COG0189	ligase activity
SynMINOS11_RS11340	COG1575	Belongs to the MenA family. Type 1 subfamily
SynMINOS11_RS11355	COG0824	Thioesterase
SynMINOS11_RS11360	COG0649	NAD binding
SynMINOS11_RS11365	COG0275	rRNA processing
SynMINOS11_RS11370	COG1104	cysteine desulfurase activity
SynMINOS11_RS11380	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_RS11385	COG0564	pseudouridine synthase activity
SynMINOS11_RS11390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynMINOS11_RS11395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SynMINOS11_RS11400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynMINOS11_RS11405	COG0628	permease
SynMINOS11_RS11410	COG0529	Catalyzes the synthesis of activated sulfate
SynMINOS11_RS11415	COG0023	Translation Initiation Factor
SynMINOS11_RS11430	COG0133	tryptophan synthase activity
SynMINOS11_RS11435	COG1420	regulation of RNA biosynthetic process
SynMINOS11_RS11450	COG2062	phosphohistidine phosphatase, SixA
SynMINOS11_RS11455	COG0372	Belongs to the citrate synthase family
SynMINOS11_RS11460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynMINOS11_RS11465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_RS11470	COG0839	Belongs to the complex I subunit 6 family
SynMINOS11_RS11480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynMINOS11_RS11520	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynMINOS11_RS11525	COG0131	Imidazoleglycerol-phosphate dehydratase
SynMINOS11_RS11535	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynMINOS11_RS11540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynMINOS11_RS11560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynMINOS11_RS11565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynMINOS11_RS11585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynMINOS11_RS11600	COG0625	glutathione transferase activity
SynMINOS11_RS11610	COG1253	flavin adenine dinucleotide binding
SynMINOS11_RS11615	COG0673	inositol 2-dehydrogenase activity
SynMINOS11_RS11635	COG0343	queuine tRNA-ribosyltransferase activity
SynMINOS11_RS11645	COG2205	protein histidine kinase activity
SynMINOS11_RS11660	COG0138	bifunctional purine biosynthesis protein purh
SynMINOS11_RS11675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynMINOS11_RS11680	COG0004	ammonium transporteR
SynMINOS11_RS11695	COG1489	DNA binding
SynMINOS11_RS11700	COG0728	peptidoglycan biosynthetic process
SynMINOS11_RS11725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynMINOS11_RS11730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynMINOS11_RS11735	COG1546	Belongs to the CinA family
SynMINOS11_RS11735	COG1058	Belongs to the CinA family
SynMINOS11_RS11740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynMINOS11_RS11745	COG0066	3-isopropylmalate dehydratase activity
SynMINOS11_RS11780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynMINOS11_RS11800	COG4372	Transposase
SynMINOS11_RS11805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMINOS11_RS11815	COG0717	Belongs to the dCTP deaminase family
SynMINOS11_RS11825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynMINOS11_RS11850	COG0167	dihydroorotate dehydrogenase activity
SynMINOS11_RS11855	COG0328	RNA-DNA hybrid ribonuclease activity
SynMINOS11_RS11860	COG0222	ribosome binding
SynMINOS11_RS11865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynMINOS11_RS11870	COG0081	regulation of translation
SynMINOS11_RS11875	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynMINOS11_RS11880	COG0250	Participates in transcription elongation, termination and antitermination
SynMINOS11_RS11885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynMINOS11_RS11890	COG0542	response to heat
SynMINOS11_RS11895	COG0346	lactoylglutathione lyase activity
SynMINOS11_RS11900	COG0148	phosphopyruvate hydratase activity
SynMINOS11_RS11905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMINOS11_RS11970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMINOS11_RS11975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMINOS11_RS11980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynMINOS11_RS11985	COG0237	dephospho-CoA kinase activity
SynMINOS11_RS11990	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynMINOS11_RS12000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynMINOS11_RS12000	COG2022	thiamine diphosphate biosynthetic process
SynMINOS11_RS12005	COG0105	UTP biosynthetic process
SynMINOS11_RS12010	COG1166	arginine decarboxylase activity
SynMINOS11_RS12050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynMINOS11_RS12055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynMINOS11_RS12070	COG0071	Belongs to the small heat shock protein (HSP20) family
SynMINOS11_RS12080	COG0426	domain, Protein
SynMINOS11_RS12080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynMINOS11_RS12085	COG0426	domain, Protein
SynMINOS11_RS12085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynMINOS11_RS12100	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynMINOS11_RS12100	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynMINOS11_RS12105	COG0509	glycine decarboxylation via glycine cleavage system
SynMINOS11_RS12110	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynMINOS11_RS12130	COG0359	binds to the 23S rRNA
SynMINOS11_RS12135	COG1372	Participates in initiation and elongation during chromosome replication
SynMINOS11_RS12135	COG0305	Participates in initiation and elongation during chromosome replication
SynMINOS11_RS12135	COG0305	Participates in initiation and elongation during chromosome replication
SynMINOS11_RS12135	COG1372	Participates in initiation and elongation during chromosome replication
SynMINOS11_RS12155	COG0445	tRNA wobble uridine modification
SynMINOS11_RS12205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynMINOS11_RS12215	COG0398	Pfam SNARE associated Golgi protein
SynMINOS11_RS12220	COG0668	transmembrane transport
SynMINOS11_RS12225	COG0525	valine-tRNA ligase activity
SynMINOS11_RS12270	COG3956	TIGRFAM MazG family protein
SynMINOS11_RS12275	COG0288	reversible hydration of carbon dioxide
SynMINOS11_RS12280	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynMINOS11_RS12285	COG0010	Belongs to the arginase family
SynMINOS11_RS12295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynMINOS11_RS12300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynMINOS11_RS12305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_RS12310	COG0783	Belongs to the Dps family
SynMINOS11_RS12320	COG0504	CTP synthase activity
SynMINOS11_RS12325	COG0602	queuosine metabolic process
SynMINOS11_RS12330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynMINOS11_RS12375	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynMINOS11_RS12385	COG0830	nickel cation binding
SynMINOS11_RS12390	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynMINOS11_RS12395	COG0829	nickel cation binding
SynMINOS11_RS12405	COG0831	urea catabolic process
SynMINOS11_RS12410	COG0832	Belongs to the urease beta subunit family
SynMINOS11_RS12415	COG0804	urea catabolic process
SynMINOS11_RS12425	COG2308	Evidence 4 Homologs of previously reported genes of
SynMINOS11_RS12460	COG4638	Rieske (2fe-2S)
SynMINOS11_RS12465	COG1116	anion transmembrane transporter activity
SynMINOS11_RS12470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynMINOS11_RS12485	COG0375	protein maturation
SynMINOS11_RS12490	COG0010	Belongs to the arginase family
SynMINOS11_RS12495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynMINOS11_RS12505	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynMINOS11_RS12515	COG2116	formate transmembrane transporter activity
SynMINOS11_RS12525	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynMINOS11_RS12530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynMINOS11_RS12545	COG0243	molybdopterin cofactor binding
SynMINOS11_RS12550	COG2223	nitrite transmembrane transporter activity
SynMINOS11_RS12555	COG0746	molybdenum cofactor guanylyltransferase activity
SynMINOS11_RS12560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynMINOS11_RS12570	COG1643	Atp-dependent helicase
SynMINOS11_RS12580	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynMINOS11_RS12590	COG0314	molybdopterin synthase activity
SynMINOS11_RS12595	COG0303	'Molybdopterin
SynMINOS11_RS12600	COG0315	cyclic pyranopterin monophosphate synthase activity
SynMINOS11_RS12605	COG0590	tRNA wobble adenosine to inosine editing
SynMINOS11_RS12615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynMINOS11_RS12620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_RS12625	COG0170	dolichyl monophosphate biosynthetic process
SynMINOS11_RS12635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynMINOS11_RS12640	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynMINOS11_RS12660	COG0788	formyltetrahydrofolate deformylase activity
SynMINOS11_RS12675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynMINOS11_RS12675	COG2022	thiamine diphosphate biosynthetic process
SynMINOS11_RS12680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMINOS11_RS12685	COG0443	Heat shock 70 kDa protein
SynMINOS11_RS12690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynMINOS11_RS12700	COG0360	Binds together with S18 to 16S ribosomal RNA
SynMINOS11_RS12710	COG0137	argininosuccinate synthase activity
SynMINOS11_RS12725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynMINOS11_RS12740	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynMINOS11_RS12755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynMINOS11_RS12760	COG0497	DNA recombination
SynMINOS11_RS12765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMINOS11_RS12775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine