locus-tag	class	description
SYN6312_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SYN6312_RS00020	COG0450	alkyl hydroperoxide reductase
SYN6312_RS00025	COG0343	queuine tRNA-ribosyltransferase activity
SYN6312_RS00030	COG4372	Transposase
SYN6312_RS00035	COG0750	zinc metalloprotease
SYN6312_RS00055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SYN6312_RS00060	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
SYN6312_RS00110	COG0004	ammonium transporteR
SYN6312_RS00115	COG4581	dead DEAH box helicase
SYN6312_RS00125	COG0840	transmembrane signaling receptor activity
SYN6312_RS00135	COG0745	RESPONSE REGULATOR receiver
SYN6312_RS00155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SYN6312_RS00160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYN6312_RS00170	COG1799	cell septum assembly
SYN6312_RS00175	COG0515	serine threonine protein kinase
SYN6312_RS00180	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYN6312_RS00185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SYN6312_RS00195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SYN6312_RS00230	COG0457	Tetratricopeptide repeat
SYN6312_RS00235	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYN6312_RS00245	COG0745	RESPONSE REGULATOR receiver
SYN6312_RS00250	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYN6312_RS00255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYN6312_RS00265	COG0275	rRNA processing
SYN6312_RS00280	COG0475	glutathione-regulated potassium exporter activity
SYN6312_RS00280	COG0589	response to stress
SYN6312_RS00295	COG0121	glutamine amidotransferase
SYN6312_RS00310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SYN6312_RS00340	COG0529	Catalyzes the synthesis of activated sulfate
SYN6312_RS00350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYN6312_RS00355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN6312_RS00360	COG3237	CsbD-like
SYN6312_RS00370	COG3237	CsbD-like
SYN6312_RS00385	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SYN6312_RS00385	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SYN6312_RS00395	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SYN6312_RS00400	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SYN6312_RS00435	COG0411	ABC transporter
SYN6312_RS00445	COG0270	DNA (cytosine-5-)-methyltransferase activity
SYN6312_RS00455	COG1836	PFAM Integral membrane protein DUF92
SYN6312_RS00460	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SYN6312_RS00460	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SYN6312_RS00475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SYN6312_RS00515	COG3852	Histidine kinase
SYN6312_RS00520	COG0745	RESPONSE REGULATOR receiver
SYN6312_RS00560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYN6312_RS00565	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SYN6312_RS00570	COG1122	ATPase activity
SYN6312_RS00580	COG0596	Alpha beta hydrolase
SYN6312_RS00585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYN6312_RS00590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYN6312_RS00595	COG0022	dehydrogenase e1 component
SYN6312_RS00595	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYN6312_RS00610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SYN6312_RS00625	COG1834	amidinotransferase
SYN6312_RS00630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYN6312_RS00635	COG0772	Belongs to the SEDS family
SYN6312_RS00640	COG5001	Diguanylate cyclase
SYN6312_RS00640	COG3300	MHYT domain
SYN6312_RS00655	COG0310	cobalt ion transport
SYN6312_RS00665	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
SYN6312_RS00680	COG2022	thiamine diphosphate biosynthetic process
SYN6312_RS00680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYN6312_RS00685	COG0589	response to stress
SYN6312_RS00715	COG2304	oxidoreductase activity
SYN6312_RS00725	COG0484	heat shock protein binding
SYN6312_RS00745	COG0488	(ABC) transporter
SYN6312_RS00755	COG0352	thiamine-phosphate diphosphorylase activity
SYN6312_RS00765	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SYN6312_RS00775	COG4636	protein conserved in cyanobacteria
SYN6312_RS00780	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SYN6312_RS00785	COG0028	Belongs to the TPP enzyme family
SYN6312_RS00800	COG0170	dolichyl monophosphate biosynthetic process
SYN6312_RS00815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYN6312_RS00820	COG1372	Participates in initiation and elongation during chromosome replication
SYN6312_RS00820	COG0187	DNA topoisomerase II activity
SYN6312_RS00865	COG0395	ABC-type sugar transport system, permease component
SYN6312_RS00875	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SYN6312_RS00880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYN6312_RS00885	COG0166	Belongs to the GPI family
SYN6312_RS00900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYN6312_RS00900	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SYN6312_RS00925	COG0537	adenosine 5'-monophosphoramidase activity
SYN6312_RS00960	COG1333	cytochrome c biogenesis protein
SYN6312_RS00975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYN6312_RS00985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SYN6312_RS01000	COG0039	L-malate dehydrogenase activity
SYN6312_RS01045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SYN6312_RS01045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYN6312_RS01055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYN6312_RS01070	COG1090	epimerase
SYN6312_RS01080	COG1840	ABC-type Fe3 transport system, periplasmic component
SYN6312_RS01090	COG3264	Mechanosensitive ion channel
SYN6312_RS01090	COG1511	domain protein
SYN6312_RS01095	COG1012	belongs to the aldehyde dehydrogenase family
SYN6312_RS01110	COG0415	Belongs to the DNA photolyase family
SYN6312_RS01120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYN6312_RS01140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SYN6312_RS01160	COG4636	protein conserved in cyanobacteria
SYN6312_RS01180	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYN6312_RS01185	COG0330	HflC and HflK could
SYN6312_RS01190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYN6312_RS01190	COG0758	DNA mediated transformation
SYN6312_RS01210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SYN6312_RS01220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYN6312_RS01220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYN6312_RS01230	COG2815	serine threonine protein kinase
SYN6312_RS01230	COG0515	serine threonine protein kinase
SYN6312_RS01235	COG0217	transcriptional regulatory protein
SYN6312_RS01255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SYN6312_RS01265	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SYN6312_RS01270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYN6312_RS01275	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SYN6312_RS01280	COG1252	NADH dehydrogenase
SYN6312_RS01295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYN6312_RS01315	COG4251	negative regulation of phosphorylation
SYN6312_RS01340	COG0793	Belongs to the peptidase S41A family
SYN6312_RS01345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SYN6312_RS01350	COG1620	l-lactate permease
SYN6312_RS01370	COG0656	L-ascorbic acid biosynthetic process
SYN6312_RS01385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYN6312_RS01390	COG2119	membrane
SYN6312_RS01395	COG0443	Heat shock 70 kDa protein
SYN6312_RS01420	COG1136	(ABC) transporter
SYN6312_RS01440	COG0463	Glycosyl transferase, family 2
SYN6312_RS01460	COG0848	biopolymer transport protein
SYN6312_RS01465	COG0811	peptide transport
SYN6312_RS01475	COG3659	wide pore channel activity
SYN6312_RS01480	COG0251	oxidation-reduction process
SYN6312_RS01510	COG4636	protein conserved in cyanobacteria
SYN6312_RS01530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYN6312_RS01555	COG0484	heat shock protein binding
SYN6312_RS01580	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SYN6312_RS01595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SYN6312_RS01600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SYN6312_RS01610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN6312_RS01625	COG0714	Associated with various cellular activities
SYN6312_RS01640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYN6312_RS01645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN6312_RS01655	COG0121	glutamine amidotransferase
SYN6312_RS01660	COG1446	asparaginase
SYN6312_RS01670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN6312_RS01690	COG3854	ATPases associated with a variety of cellular activities
SYN6312_RS01705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SYN6312_RS01710	COG0633	Ferredoxin
SYN6312_RS01725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYN6312_RS01770	COG1253	flavin adenine dinucleotide binding
SYN6312_RS01775	COG0434	BtpA family
SYN6312_RS01785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYN6312_RS01790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SYN6312_RS01795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SYN6312_RS01800	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYN6312_RS01805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYN6312_RS01810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYN6312_RS01815	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SYN6312_RS01835	COG4106	trans-aconitate 2-methyltransferase activity
SYN6312_RS01840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SYN6312_RS01855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SYN6312_RS01875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYN6312_RS01905	COG0515	serine threonine protein kinase
SYN6312_RS01905	COG1357	PFAM Pentapeptide repeats (8 copies)
SYN6312_RS01910	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYN6312_RS01920	COG2814	Major facilitator Superfamily
SYN6312_RS01930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SYN6312_RS01935	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYN6312_RS01940	COG0277	FAD linked oxidase domain protein
SYN6312_RS01945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SYN6312_RS01975	COG0497	DNA recombination
SYN6312_RS01985	COG1160	GTP binding
SYN6312_RS02045	COG0165	Argininosuccinate lyase
SYN6312_RS02065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SYN6312_RS02095	COG0047	phosphoribosylformylglycinamidine synthase activity
SYN6312_RS02105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYN6312_RS02115	COG0596	Alpha beta hydrolase
SYN6312_RS02140	COG0745	RESPONSE REGULATOR receiver
SYN6312_RS02145	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SYN6312_RS02160	COG0739	heme binding
SYN6312_RS02165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYN6312_RS02190	COG1598	PFAM Uncharacterised protein family UPF0150
SYN6312_RS02195	COG0509	glycine decarboxylation via glycine cleavage system
SYN6312_RS02200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYN6312_RS02210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SYN6312_RS02220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYN6312_RS02225	COG2197	response regulator
SYN6312_RS02255	COG0445	tRNA wobble uridine modification
SYN6312_RS02285	COG0765	amino acid transport
SYN6312_RS02310	COG0196	riboflavin kinase activity
SYN6312_RS02315	COG0612	Peptidase, M16
SYN6312_RS02350	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SYN6312_RS02355	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SYN6312_RS02360	COG4208	sulfate ABC transporter
SYN6312_RS02365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SYN6312_RS02385	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
SYN6312_RS02390	COG0617	tRNA 3'-terminal CCA addition
SYN6312_RS02395	COG0552	protein localization to endoplasmic reticulum
SYN6312_RS02400	COG3064	Membrane
SYN6312_RS02400	COG4991	sh3 domain protein
SYN6312_RS02400	COG0515	serine threonine protein kinase
SYN6312_RS02405	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SYN6312_RS02410	COG1126	abc transporter atp-binding protein
SYN6312_RS02420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYN6312_RS02425	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SYN6312_RS02435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYN6312_RS02450	COG4636	protein conserved in cyanobacteria
SYN6312_RS02485	COG2094	Belongs to the DNA glycosylase MPG family
SYN6312_RS02490	COG1116	anion transmembrane transporter activity
SYN6312_RS02495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYN6312_RS02520	COG0540	Belongs to the ATCase OTCase family
SYN6312_RS02525	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SYN6312_RS02530	COG3937	granule-associated protein
SYN6312_RS02545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYN6312_RS02550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SYN6312_RS02555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SYN6312_RS02580	COG0109	protoheme IX farnesyltransferase activity
SYN6312_RS02595	COG2217	Heavy metal translocating P-type atpase
SYN6312_RS02615	COG0284	orotidine-5'-phosphate decarboxylase activity
SYN6312_RS02620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SYN6312_RS02635	COG0484	heat shock protein binding
SYN6312_RS02640	COG1459	type II secretion system
SYN6312_RS02650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYN6312_RS02655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SYN6312_RS02665	COG0484	heat shock protein binding
SYN6312_RS02675	COG1162	GTPase activity
SYN6312_RS02685	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SYN6312_RS02705	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYN6312_RS02710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SYN6312_RS02715	COG3063	Type IV pilus biogenesis stability protein PilW
SYN6312_RS02725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYN6312_RS02740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SYN6312_RS02745	COG0557	exoribonuclease II activity
SYN6312_RS02750	COG0629	single-stranded DNA binding
SYN6312_RS02755	COG4243	Vitamin k epoxide reductase
SYN6312_RS02760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SYN6312_RS02775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYN6312_RS02790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SYN6312_RS02795	COG0640	Transcriptional regulator
SYN6312_RS02800	COG0602	queuosine metabolic process
SYN6312_RS02810	COG0205	6-phosphofructokinase activity
SYN6312_RS02815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYN6312_RS02830	COG2267	carboxylic ester hydrolase activity
SYN6312_RS02835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SYN6312_RS02845	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SYN6312_RS02850	COG2843	Capsule synthesis protein
SYN6312_RS02865	COG0133	tryptophan synthase activity
SYN6312_RS02890	COG0739	heme binding
SYN6312_RS02900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYN6312_RS02915	COG0191	fructose-bisphosphate aldolase activity
SYN6312_RS02920	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SYN6312_RS02925	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SYN6312_RS02935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SYN6312_RS02940	COG2385	sporulation resulting in formation of a cellular spore
SYN6312_RS02950	COG0473	3-isopropylmalate dehydrogenase activity
SYN6312_RS02960	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SYN6312_RS02970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SYN6312_RS02975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SYN6312_RS02980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SYN6312_RS03005	COG1496	oxidoreductase activity
SYN6312_RS03010	COG0459	protein refolding
SYN6312_RS03015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SYN6312_RS03030	COG0779	Required for maturation of 30S ribosomal subunits
SYN6312_RS03035	COG0195	Participates in both transcription termination and antitermination
SYN6312_RS03045	COG0714	Associated with various cellular activities
SYN6312_RS03050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SYN6312_RS03065	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SYN6312_RS03085	COG0824	Thioesterase
SYN6312_RS03100	COG1741	Belongs to the pirin family
SYN6312_RS03110	COG1733	regulation of RNA biosynthetic process
SYN6312_RS03120	COG1012	belongs to the aldehyde dehydrogenase family
SYN6312_RS03125	COG0612	Peptidase, M16
SYN6312_RS03145	COG0004	ammonium transporteR
SYN6312_RS03170	COG0667	Aldo Keto reductase
SYN6312_RS03180	COG0592	DNA-directed DNA polymerase activity
SYN6312_RS03200	COG0697	spore germination
SYN6312_RS03205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SYN6312_RS03220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYN6312_RS03225	COG0424	maF-like protein
SYN6312_RS03230	COG1376	ErfK ybiS ycfS ynhG family protein
SYN6312_RS03240	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYN6312_RS03275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYN6312_RS03280	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SYN6312_RS03280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SYN6312_RS03285	COG1716	ATPase activity
SYN6312_RS03285	COG5001	Diguanylate cyclase
SYN6312_RS03315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYN6312_RS03320	COG0539	negative regulation of cytoplasmic translation
SYN6312_RS03325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SYN6312_RS03350	COG1136	(ABC) transporter
SYN6312_RS03350	COG0577	efflux transmembrane transporter activity
SYN6312_RS03415	COG2244	polysaccharide biosynthetic process
SYN6312_RS03425	COG1216	Glycosyl transferase, family 2
SYN6312_RS03430	COG1215	transferase activity, transferring glycosyl groups
SYN6312_RS03435	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SYN6312_RS03440	COG1216	Glycosyl transferase, family 2
SYN6312_RS03460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYN6312_RS03495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYN6312_RS03500	COG1132	(ABC) transporter
SYN6312_RS03505	COG0739	heme binding
SYN6312_RS03530	COG3411	Ferredoxin
SYN6312_RS03535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYN6312_RS03540	COG0463	Glycosyl transferase, family 2
SYN6312_RS03545	COG0110	maltose O-acetyltransferase activity
SYN6312_RS03550	COG0438	transferase activity, transferring glycosyl groups
SYN6312_RS03560	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SYN6312_RS03570	COG0438	transferase activity, transferring glycosyl groups
SYN6312_RS03595	COG1083	cytidylyl-transferase
SYN6312_RS03615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYN6312_RS03640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYN6312_RS03645	COG1132	(ABC) transporter
SYN6312_RS03660	COG1596	polysaccharide export
SYN6312_RS03690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYN6312_RS03705	COG0501	Belongs to the peptidase M48B family
SYN6312_RS03710	COG1970	mechanosensitive ion channel activity
SYN6312_RS03730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYN6312_RS03735	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYN6312_RS03745	COG0384	phenazine biosynthesis protein PhzF
SYN6312_RS03750	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYN6312_RS03755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SYN6312_RS03760	COG0515	serine threonine protein kinase
SYN6312_RS03775	COG0857	belongs to the CobB CobQ family
SYN6312_RS03790	COG1215	transferase activity, transferring glycosyl groups
SYN6312_RS03800	COG0586	Pfam SNARE associated Golgi protein
SYN6312_RS03805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SYN6312_RS03810	COG0194	GDP metabolic process
SYN6312_RS03815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYN6312_RS03815	COG0426	domain, Protein
SYN6312_RS03820	COG1598	PFAM Uncharacterised protein family UPF0150
SYN6312_RS03850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYN6312_RS03850	COG0426	domain, Protein
SYN6312_RS03855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYN6312_RS03860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYN6312_RS03865	COG0557	exoribonuclease II activity
SYN6312_RS03885	COG2046	Belongs to the sulfate adenylyltransferase family
SYN6312_RS03895	COG0793	Belongs to the peptidase S41A family
SYN6312_RS03900	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SYN6312_RS03920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SYN6312_RS03940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SYN6312_RS03945	COG0052	Belongs to the universal ribosomal protein uS2 family
SYN6312_RS03955	COG0564	pseudouridine synthase activity
SYN6312_RS03960	COG3437	response regulator, receiver
SYN6312_RS03965	COG1959	2 iron, 2 sulfur cluster binding
SYN6312_RS03970	COG1619	proteins homologs of microcin C7 resistance protein MccF
SYN6312_RS03980	COG0735	belongs to the Fur family
SYN6312_RS03990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SYN6312_RS04000	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SYN6312_RS04015	COG1716	ATPase activity
SYN6312_RS04015	COG1131	(ABC) transporter
SYN6312_RS04015	COG0842	Transport permease protein
SYN6312_RS04030	COG2217	Heavy metal translocating P-type atpase
SYN6312_RS04095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SYN6312_RS04100	COG1555	photosystem II stabilization
SYN6312_RS04110	COG1268	BioY protein
SYN6312_RS04130	COG0504	CTP synthase activity
SYN6312_RS04165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYN6312_RS04285	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SYN6312_RS04305	COG0732	type I restriction modification DNA specificity domain
SYN6312_RS04325	COG4636	protein conserved in cyanobacteria
SYN6312_RS04330	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SYN6312_RS04335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYN6312_RS04415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYN6312_RS04425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SYN6312_RS04450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SYN6312_RS04475	COG0724	RNA recognition motif
SYN6312_RS04480	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SYN6312_RS04490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SYN6312_RS04515	COG0210	DNA helicase
SYN6312_RS04515	COG0210	DNA helicase
SYN6312_RS04535	COG1666	GTP binding
SYN6312_RS04560	COG1166	arginine decarboxylase activity
SYN6312_RS04570	COG1122	ATPase activity
SYN6312_RS04580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SYN6312_RS04585	COG0396	ATPase activity
SYN6312_RS04590	COG0719	Fe-S assembly protein
SYN6312_RS04605	COG2048	Heterodisulfide reductase, subunit B
SYN6312_RS04610	COG1981	membrane
SYN6312_RS04615	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYN6312_RS04640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYN6312_RS04645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SYN6312_RS04655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SYN6312_RS04665	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
SYN6312_RS04670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYN6312_RS04685	COG1494	fructose-1,6-bisphosphatase
SYN6312_RS04695	COG0335	large ribosomal subunit rRNA binding
SYN6312_RS04705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SYN6312_RS04745	COG1234	tRNA 3'-trailer cleavage
SYN6312_RS04745	COG1555	photosystem II stabilization
SYN6312_RS04750	COG2307	Protein conserved in bacteria
SYN6312_RS04750	COG2308	Evidence 4 Homologs of previously reported genes of
SYN6312_RS04760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SYN6312_RS04765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SYN6312_RS04770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SYN6312_RS04775	COG0523	cobalamin synthesis protein
SYN6312_RS04790	COG0004	ammonium transporteR
SYN6312_RS04800	COG2884	Cell division ATP-binding protein ftsE
SYN6312_RS04810	COG0586	Pfam SNARE associated Golgi protein
SYN6312_RS04825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SYN6312_RS04855	COG1733	regulation of RNA biosynthetic process
SYN6312_RS04880	COG1408	metallophosphoesterase
SYN6312_RS04890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN6312_RS04905	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SYN6312_RS04910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SYN6312_RS04995	COG1217	gtp-binding protein TYPA
SYN6312_RS05010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SYN6312_RS05015	COG0316	Belongs to the HesB IscA family
SYN6312_RS05020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SYN6312_RS05025	COG0572	uridine kinase
SYN6312_RS05030	COG1193	negative regulation of DNA recombination
SYN6312_RS05035	COG1007	ATP synthesis coupled electron transport
SYN6312_RS05040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SYN6312_RS05055	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SYN6312_RS05065	COG0625	glutathione transferase activity
SYN6312_RS05070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SYN6312_RS05080	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SYN6312_RS05145	COG1104	cysteine desulfurase activity
SYN6312_RS05150	COG0288	reversible hydration of carbon dioxide
SYN6312_RS05155	COG0167	dihydroorotate dehydrogenase activity
SYN6312_RS05175	COG0251	oxidation-reduction process
SYN6312_RS05185	COG1587	Uroporphyrinogen-III synthase
SYN6312_RS05190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYN6312_RS05200	COG1722	exodeoxyribonuclease VII activity
SYN6312_RS05205	COG0488	(ABC) transporter
SYN6312_RS05220	COG0134	indole-3-glycerol-phosphate synthase activity
SYN6312_RS05230	COG1742	UPF0060 membrane protein
SYN6312_RS05240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYN6312_RS05265	COG2197	response regulator
SYN6312_RS05270	COG4585	Histidine kinase
SYN6312_RS05290	COG0577	efflux transmembrane transporter activity
SYN6312_RS05290	COG1136	(ABC) transporter
SYN6312_RS05300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYN6312_RS05305	COG0583	DNA-binding transcription factor activity
SYN6312_RS05315	COG2223	nitrite transmembrane transporter activity
SYN6312_RS05320	COG0243	molybdopterin cofactor binding
SYN6312_RS05360	COG0303	'Molybdopterin
SYN6312_RS05365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYN6312_RS05370	COG0746	molybdenum cofactor guanylyltransferase activity
SYN6312_RS05370	COG0315	cyclic pyranopterin monophosphate synthase activity
SYN6312_RS05380	COG0314	molybdopterin synthase activity
SYN6312_RS05385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYN6312_RS05410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYN6312_RS05415	COG0589	response to stress
SYN6312_RS05430	COG0436	Aminotransferase
SYN6312_RS05450	COG0751	glycine-tRNA ligase activity
SYN6312_RS05480	COG0484	heat shock protein binding
SYN6312_RS05695	COG0776	regulation of translation
SYN6312_RS05750	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SYN6312_RS05755	COG1518	maintenance of DNA repeat elements
SYN6312_RS05755	COG1468	defense response to virus
SYN6312_RS05775	COG1857	crispr-associated protein
SYN6312_RS05785	COG1203	CRISPR-associated helicase, Cas3
SYN6312_RS05825	COG0297	glycogen (starch) synthase activity
SYN6312_RS05830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYN6312_RS05835	COG2154	pterin-4-alpha-carbinolamine dehydratase
SYN6312_RS05845	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SYN6312_RS05855	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYN6312_RS05865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SYN6312_RS05870	COG0830	nickel cation binding
SYN6312_RS05875	COG3001	Fructosamine kinase
SYN6312_RS05890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SYN6312_RS05895	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SYN6312_RS05905	COG1376	ErfK ybiS ycfS ynhG family protein
SYN6312_RS05915	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SYN6312_RS05925	COG0439	Biotin carboxylase
SYN6312_RS05935	COG2255	four-way junction helicase activity
SYN6312_RS05940	COG0483	inositol monophosphate 1-phosphatase activity
SYN6312_RS05960	COG2217	Heavy metal translocating P-type atpase
SYN6312_RS05965	COG0788	formyltetrahydrofolate deformylase activity
SYN6312_RS05975	COG0745	RESPONSE REGULATOR receiver
SYN6312_RS05985	COG0051	transcription antitermination factor activity, RNA binding
SYN6312_RS05990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SYN6312_RS05995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYN6312_RS06000	COG0049	tRNA binding
SYN6312_RS06005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SYN6312_RS06015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYN6312_RS06020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYN6312_RS06025	COG0085	RNA polymerase activity
SYN6312_RS06030	COG4221	oxidoreductase activity
SYN6312_RS06075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYN6312_RS06080	COG0416	fatty acid biosynthetic process
SYN6312_RS06090	COG0095	Lipoate-protein ligase
SYN6312_RS06095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYN6312_RS06100	COG2226	methyltransferase
SYN6312_RS06105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SYN6312_RS06135	COG0765	amino acid transport
SYN6312_RS06160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SYN6312_RS06165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYN6312_RS06170	COG0768	penicillin binding
SYN6312_RS06175	COG0463	Glycosyl transferase, family 2
SYN6312_RS06185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYN6312_RS06190	COG2832	Protein of unknown function (DUF454)
SYN6312_RS06210	COG0601	transmembrane transport
SYN6312_RS06220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYN6312_RS06220	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYN6312_RS06235	COG0831	urea catabolic process
SYN6312_RS06240	COG0829	nickel cation binding
SYN6312_RS06245	COG3258	Cytochrome c
SYN6312_RS06255	COG1122	ATPase activity
SYN6312_RS06265	COG1473	amidohydrolase
SYN6312_RS06280	COG1294	oxidase, subunit
SYN6312_RS06285	COG1271	oxidase subunit
SYN6312_RS06290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYN6312_RS06300	COG0495	leucyl-tRNA aminoacylation
SYN6312_RS06320	COG1215	transferase activity, transferring glycosyl groups
SYN6312_RS06335	COG1216	Glycosyl transferase, family 2
SYN6312_RS06355	COG2822	iron ion transport
SYN6312_RS06360	COG3128	pkhd-type hydroxylase
SYN6312_RS06365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYN6312_RS06365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYN6312_RS06370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYN6312_RS06400	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SYN6312_RS06405	COG2319	Wd-40 repeat
SYN6312_RS06410	COG2319	Wd-40 repeat
SYN6312_RS06415	COG2264	protein methyltransferase activity
SYN6312_RS06420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SYN6312_RS06435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SYN6312_RS06445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN6312_RS06465	COG0784	Response regulator, receiver
SYN6312_RS06465	COG2205	protein histidine kinase activity
SYN6312_RS06465	COG5002	protein histidine kinase activity
SYN6312_RS06480	COG0037	tRNA processing
SYN6312_RS06485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYN6312_RS06495	COG1073	alpha beta
SYN6312_RS06620	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYN6312_RS06625	COG0248	Ppx GppA phosphatase
SYN6312_RS06635	COG0643	Histidine kinase
SYN6312_RS06635	COG0784	Response regulator, receiver
SYN6312_RS06635	COG2198	Histidine kinase
SYN6312_RS06640	COG2203	Gaf domain
SYN6312_RS06640	COG0840	transmembrane signaling receptor activity
SYN6312_RS06655	COG0784	Response regulator, receiver
SYN6312_RS06665	COG2003	Belongs to the UPF0758 family
SYN6312_RS06670	COG3659	wide pore channel activity
SYN6312_RS06685	COG0454	-acetyltransferase
SYN6312_RS06685	COG0456	acetyltransferase
SYN6312_RS06690	COG0019	diaminopimelate decarboxylase activity
SYN6312_RS06695	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SYN6312_RS06700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SYN6312_RS06710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYN6312_RS06720	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SYN6312_RS06725	COG1773	rubredoxin
SYN6312_RS06730	COG4447	cellulose binding
SYN6312_RS06790	COG0322	excinuclease ABC activity
SYN6312_RS06795	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYN6312_RS06845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SYN6312_RS06850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYN6312_RS06900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SYN6312_RS06915	COG3659	wide pore channel activity
SYN6312_RS06920	COG4597	amino acid ABC transporter
SYN6312_RS06925	COG0765	amino acid transport
SYN6312_RS06930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SYN6312_RS06940	COG0484	heat shock protein binding
SYN6312_RS06945	COG0287	Prephenate dehydrogenase
SYN6312_RS06955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SYN6312_RS06980	COG0517	IMP dehydrogenase activity
SYN6312_RS06980	COG0617	tRNA 3'-terminal CCA addition
SYN6312_RS06980	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SYN6312_RS06990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN6312_RS07000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYN6312_RS07010	COG0805	protein transport
SYN6312_RS07025	COG1175	transmembrane transport
SYN6312_RS07030	COG0628	permease
SYN6312_RS07055	COG0632	four-way junction helicase activity
SYN6312_RS07060	COG1657	PFAM Prenyltransferase squalene oxidase
SYN6312_RS07065	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYN6312_RS07065	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYN6312_RS07070	COG2890	protein-(glutamine-N5) methyltransferase activity
SYN6312_RS07075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SYN6312_RS07080	COG3536	Protein conserved in bacteria
SYN6312_RS07090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SYN6312_RS07095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYN6312_RS07100	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SYN6312_RS07125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYN6312_RS07140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYN6312_RS07145	COG0436	Aminotransferase
SYN6312_RS07165	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SYN6312_RS07175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SYN6312_RS07185	COG2274	protein secretion by the type I secretion system
SYN6312_RS07210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYN6312_RS07225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYN6312_RS07260	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SYN6312_RS07280	COG0302	gtp cyclohydrolase
SYN6312_RS07285	COG4221	oxidoreductase activity
SYN6312_RS07290	COG0825	malonyl-CoA metabolic process
SYN6312_RS07295	COG5322	oxidoreductase activity
SYN6312_RS07300	COG1606	tRNA processing
SYN6312_RS07305	COG1187	pseudouridine synthase activity
SYN6312_RS07310	COG0138	bifunctional purine biosynthesis protein purh
SYN6312_RS07325	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SYN6312_RS07330	COG0357	Ribosomal RNA small subunit methyltransferase G
SYN6312_RS07335	COG0310	cobalt ion transport
SYN6312_RS07345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SYN6312_RS07350	COG2205	protein histidine kinase activity
SYN6312_RS07355	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYN6312_RS07360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SYN6312_RS07365	COG2066	Belongs to the glutaminase family
SYN6312_RS07370	COG0285	dihydrofolate synthase activity
SYN6312_RS07390	COG0737	Belongs to the 5'-nucleotidase family
SYN6312_RS07395	COG0058	SHG alpha-glucan phosphorylase activity
SYN6312_RS07400	COG4251	negative regulation of phosphorylation
SYN6312_RS07400	COG5001	Diguanylate cyclase
SYN6312_RS07400	COG2203	Gaf domain
SYN6312_RS07400	COG3706	GGDEF domain
SYN6312_RS07405	COG2204	response regulator
SYN6312_RS07415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYN6312_RS07420	COG0459	protein refolding
SYN6312_RS07425	COG1032	radical SAM domain protein
SYN6312_RS07430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SYN6312_RS07435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYN6312_RS07445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SYN6312_RS07450	COG0745	RESPONSE REGULATOR receiver
SYN6312_RS07465	COG1733	regulation of RNA biosynthetic process
SYN6312_RS07470	COG1136	(ABC) transporter
SYN6312_RS07500	COG1309	transcriptional regulator
SYN6312_RS07525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYN6312_RS07530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SYN6312_RS07535	COG2319	Wd-40 repeat
SYN6312_RS07535	COG1672	PFAM Archaeal ATPase
SYN6312_RS07555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SYN6312_RS07565	COG3118	belongs to the thioredoxin family
SYN6312_RS07570	COG0516	GMP reductase activity
SYN6312_RS07580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYN6312_RS07605	COG0297	glycogen (starch) synthase activity
SYN6312_RS07630	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYN6312_RS07635	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SYN6312_RS07645	COG0215	cysteine-tRNA ligase activity
SYN6312_RS07655	COG0649	NAD binding
SYN6312_RS07665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SYN6312_RS07670	COG0406	alpha-ribazole phosphatase activity
SYN6312_RS07695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SYN6312_RS07695	COG0574	Belongs to the PEP-utilizing enzyme family
SYN6312_RS07705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYN6312_RS07710	COG1196	nuclear chromosome segregation
SYN6312_RS07725	COG0154	amidase activity
SYN6312_RS07740	COG0515	serine threonine protein kinase
SYN6312_RS07740	COG1357	PFAM Pentapeptide repeats (8 copies)
SYN6312_RS07755	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SYN6312_RS07760	COG0742	ribosomal rna small subunit methyltransferase
SYN6312_RS07765	COG2226	methyltransferase
SYN6312_RS07770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYN6312_RS07780	COG4172	Belongs to the ABC transporter superfamily
SYN6312_RS07790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYN6312_RS07815	COG0346	lactoylglutathione lyase activity
SYN6312_RS07820	COG0431	NADPH-dependent FMN reductase
SYN6312_RS07830	COG1361	Conserved repeat domain
SYN6312_RS07835	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SYN6312_RS07855	COG0668	transmembrane transport
SYN6312_RS07890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SYN6312_RS07890	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SYN6312_RS07915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SYN6312_RS07920	COG0385	Bile acid
SYN6312_RS07935	COG1316	TRANSCRIPTIONal
SYN6312_RS07940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYN6312_RS07950	COG1012	belongs to the aldehyde dehydrogenase family
SYN6312_RS07970	COG0419	ATPase involved in DNA repair
SYN6312_RS07985	COG2226	methyltransferase
SYN6312_RS07995	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SYN6312_RS08000	COG2361	Protein of unknown function DUF86
SYN6312_RS08025	COG1562	ergosterol biosynthetic process
SYN6312_RS08030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SYN6312_RS08030	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYN6312_RS08065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SYN6312_RS08070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SYN6312_RS08080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SYN6312_RS08085	COG3842	ATPase activity
SYN6312_RS08095	COG1316	TRANSCRIPTIONal
SYN6312_RS08200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYN6312_RS08220	COG1846	Transcriptional regulator
SYN6312_RS08235	COG0514	ATP-dependent DNA helicase (RecQ)
SYN6312_RS08345	COG0159	tryptophan synthase activity
SYN6312_RS08350	COG0737	Belongs to the 5'-nucleotidase family
SYN6312_RS08365	COG0142	geranyltranstransferase activity
SYN6312_RS08370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SYN6312_RS08385	COG1397	ADP-ribosylglycohydrolase
SYN6312_RS08420	COG3309	Virulence-associated protein D
SYN6312_RS08435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SYN6312_RS08450	COG1289	transmembrane transporter activity
SYN6312_RS08460	COG0475	glutathione-regulated potassium exporter activity
SYN6312_RS08465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYN6312_RS08470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYN6312_RS08470	COG4451	ribulose bisphosphate carboxylase, small
SYN6312_RS08475	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
SYN6312_RS08480	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYN6312_RS08485	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYN6312_RS08495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYN6312_RS08500	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYN6312_RS08535	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYN6312_RS08540	COG0644	oxidoreductase
SYN6312_RS08545	COG0515	serine threonine protein kinase
SYN6312_RS08555	COG0438	transferase activity, transferring glycosyl groups
SYN6312_RS08560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYN6312_RS08570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYN6312_RS08590	COG0475	glutathione-regulated potassium exporter activity
SYN6312_RS08600	COG1366	Belongs to the anti-sigma-factor antagonist family
SYN6312_RS08610	COG0575	Belongs to the CDS family
SYN6312_RS08615	COG0484	heat shock protein binding
SYN6312_RS08620	COG0129	dihydroxy-acid dehydratase activity
SYN6312_RS08635	COG2197	response regulator
SYN6312_RS08640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SYN6312_RS08645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SYN6312_RS08660	COG0438	transferase activity, transferring glycosyl groups
SYN6312_RS08660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYN6312_RS08670	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SYN6312_RS08680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SYN6312_RS08695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYN6312_RS08700	COG0765	amino acid transport
SYN6312_RS08705	COG0181	hydroxymethylbilane synthase activity
SYN6312_RS08710	COG5001	Diguanylate cyclase
SYN6312_RS08720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYN6312_RS08725	COG0489	protein tyrosine kinase activity
SYN6312_RS08730	COG2205	protein histidine kinase activity
SYN6312_RS08740	COG1178	ABC-type Fe3 transport system permease component
SYN6312_RS08760	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SYN6312_RS08770	COG1136	(ABC) transporter
SYN6312_RS08795	COG1640	4-alpha-glucanotransferase
SYN6312_RS08820	COG2226	methyltransferase
SYN6312_RS08835	COG1131	(ABC) transporter
SYN6312_RS08850	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SYN6312_RS08875	COG0358	DNA primase activity
SYN6312_RS08925	COG0442	prolyl-tRNA aminoacylation
SYN6312_RS08940	COG4221	oxidoreductase activity
SYN6312_RS08955	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYN6312_RS08960	COG0670	Belongs to the BI1 family
SYN6312_RS08970	COG0525	valine-tRNA ligase activity
SYN6312_RS08985	COG0629	single-stranded DNA binding
SYN6312_RS08990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYN6312_RS09010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SYN6312_RS09025	COG0832	Belongs to the urease beta subunit family
SYN6312_RS09035	COG0193	aminoacyl-tRNA hydrolase activity
SYN6312_RS09040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYN6312_RS09060	COG0250	Participates in transcription elongation, termination and antitermination
SYN6312_RS09065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SYN6312_RS09070	COG0081	regulation of translation
SYN6312_RS09075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SYN6312_RS09080	COG0222	ribosome binding
SYN6312_RS09100	COG0483	inositol monophosphate 1-phosphatase activity
SYN6312_RS09105	COG2010	Cytochrome c
SYN6312_RS09110	COG2010	Cytochrome c
SYN6312_RS09115	COG2010	Cytochrome c
SYN6312_RS09120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SYN6312_RS09125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SYN6312_RS09130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SYN6312_RS09150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SYN6312_RS09160	COG2226	methyltransferase
SYN6312_RS09170	COG2022	thiamine diphosphate biosynthetic process
SYN6312_RS09175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYN6312_RS09205	COG0673	inositol 2-dehydrogenase activity
SYN6312_RS09215	COG0009	L-threonylcarbamoyladenylate synthase
SYN6312_RS09230	COG5002	protein histidine kinase activity
SYN6312_RS09250	COG0789	Transcriptional regulator
SYN6312_RS09255	COG1598	PFAM Uncharacterised protein family UPF0150
SYN6312_RS09285	COG1309	transcriptional regulator
SYN6312_RS09310	COG4178	(ABC) transporter
SYN6312_RS09315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SYN6312_RS09330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SYN6312_RS09340	COG2226	methyltransferase
SYN6312_RS09345	COG0339	signal peptide processing
SYN6312_RS09355	COG0477	Major facilitator Superfamily
SYN6312_RS09390	COG0006	proline dipeptidase activity
SYN6312_RS09400	COG0408	coproporphyrinogen oxidase activity
SYN6312_RS09410	COG0300	oxidoreductase activity
SYN6312_RS09430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SYN6312_RS09450	COG1216	Glycosyl transferase, family 2
SYN6312_RS09455	COG1216	Glycosyl transferase, family 2
SYN6312_RS09460	COG1215	transferase activity, transferring glycosyl groups
SYN6312_RS09465	COG1216	Glycosyl transferase, family 2
SYN6312_RS09465	COG1442	glycosyl transferase family 8
SYN6312_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
SYN6312_RS09480	COG1132	(ABC) transporter
SYN6312_RS09515	COG2045	Belongs to the ComB family
SYN6312_RS09530	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SYN6312_RS09575	COG0463	Glycosyl transferase, family 2
SYN6312_RS09575	COG0457	Tetratricopeptide repeat
SYN6312_RS09580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SYN6312_RS09585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SYN6312_RS09600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SYN6312_RS09605	COG0124	histidyl-tRNA synthetase
SYN6312_RS09610	COG1850	ribulose-bisphosphate carboxylase activity
SYN6312_RS09620	COG4451	ribulose bisphosphate carboxylase, small
SYN6312_RS09630	COG1160	GTP binding
SYN6312_RS09635	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SYN6312_RS09645	COG0772	Belongs to the SEDS family
SYN6312_RS09655	COG0587	DNA-directed DNA polymerase activity
SYN6312_RS09660	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYN6312_RS09670	COG1357	PFAM Pentapeptide repeats (8 copies)
SYN6312_RS09670	COG0515	serine threonine protein kinase
SYN6312_RS09685	COG5398	heme oxygenase
SYN6312_RS09690	COG0802	atpase or kinase
SYN6312_RS09715	COG1064	alcohol dehydrogenase
SYN6312_RS09730	COG1575	Belongs to the MenA family. Type 1 subfamily
SYN6312_RS09825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYN6312_RS09830	COG1061	Type III restriction enzyme res subunit
SYN6312_RS09860	COG4636	protein conserved in cyanobacteria
SYN6312_RS09905	COG1895	HEPN domain
SYN6312_RS09925	COG1002	Type II restriction enzyme, methylase subunits
SYN6312_RS09945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYN6312_RS09995	COG0135	phosphoribosylanthranilate isomerase activity
SYN6312_RS10035	COG1215	transferase activity, transferring glycosyl groups
SYN6312_RS10040	COG0716	FMN binding
SYN6312_RS10060	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SYN6312_RS10065	COG1192	Involved in chromosome partitioning
SYN6312_RS10080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SYN6312_RS10085	COG1366	Belongs to the anti-sigma-factor antagonist family
SYN6312_RS10090	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SYN6312_RS10095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SYN6312_RS10100	COG1073	alpha beta
SYN6312_RS10105	COG0469	pyruvate kinase activity
SYN6312_RS10110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYN6312_RS10120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYN6312_RS10125	COG0752	glycyl-tRNA synthetase alpha subunit
SYN6312_RS10150	COG1082	Xylose isomerase domain protein TIM barrel
SYN6312_RS10165	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SYN6312_RS10190	COG1366	Belongs to the anti-sigma-factor antagonist family
SYN6312_RS10205	COG2770	Histidine kinase
SYN6312_RS10205	COG2208	phosphoserine phosphatase activity
SYN6312_RS10215	COG2223	nitrite transmembrane transporter activity
SYN6312_RS10220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SYN6312_RS10270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SYN6312_RS10285	COG0612	Peptidase, M16
SYN6312_RS10295	COG0582	viral genome integration into host DNA
SYN6312_RS10300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SYN6312_RS10305	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SYN6312_RS10310	COG0363	glucosamine-6-phosphate deaminase activity
SYN6312_RS10315	COG1716	ATPase activity
SYN6312_RS10315	COG1716	ATPase activity
SYN6312_RS10320	COG0515	serine threonine protein kinase
SYN6312_RS10335	COG0126	phosphoglycerate kinase activity
SYN6312_RS10340	COG0589	response to stress
SYN6312_RS10350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SYN6312_RS10355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SYN6312_RS10360	COG5001	Diguanylate cyclase
SYN6312_RS10360	COG4251	negative regulation of phosphorylation
SYN6312_RS10360	COG2203	Gaf domain
SYN6312_RS10360	COG3706	GGDEF domain
SYN6312_RS10365	COG2205	protein histidine kinase activity
SYN6312_RS10365	COG0784	Response regulator, receiver
SYN6312_RS10380	COG0601	transmembrane transport
SYN6312_RS10390	COG2176	DNA-directed DNA polymerase activity
SYN6312_RS10400	COG3842	ATPase activity
SYN6312_RS10420	COG0113	porphobilinogen synthase activity
SYN6312_RS10425	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SYN6312_RS10435	COG1136	(ABC) transporter
SYN6312_RS10435	COG0577	efflux transmembrane transporter activity
SYN6312_RS10440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYN6312_RS10440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYN6312_RS10445	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SYN6312_RS10460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SYN6312_RS10465	COG2873	o-acetylhomoserine
SYN6312_RS10495	COG1285	pathogenesis
SYN6312_RS10500	COG2897	thiosulfate sulfurtransferase activity
SYN6312_RS10515	COG0312	modulator of DNA gyrase
SYN6312_RS10525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYN6312_RS10530	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SYN6312_RS10545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYN6312_RS10555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYN6312_RS10575	COG1132	(ABC) transporter
SYN6312_RS10590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SYN6312_RS10605	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SYN6312_RS10610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYN6312_RS10615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SYN6312_RS10625	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYN6312_RS10635	COG0473	3-isopropylmalate dehydrogenase activity
SYN6312_RS10640	COG2208	phosphoserine phosphatase activity
SYN6312_RS10670	COG0783	Belongs to the Dps family
SYN6312_RS10680	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYN6312_RS10705	COG0033	Phosphoglucomutase
SYN6312_RS10710	COG1077	Cell shape determining protein MreB Mrl
SYN6312_RS10715	COG1792	Involved in formation and maintenance of cell shape
SYN6312_RS10730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SYN6312_RS10735	COG0436	Aminotransferase
SYN6312_RS10740	COG0371	Dehydrogenase
SYN6312_RS10790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SYN6312_RS10795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYN6312_RS10810	COG0641	radical SAM
SYN6312_RS10825	COG0351	phosphomethylpyrimidine kinase
SYN6312_RS10830	COG0842	Transport permease protein
SYN6312_RS10830	COG1131	(ABC) transporter
SYN6312_RS10830	COG1716	ATPase activity
SYN6312_RS10840	COG1570	exodeoxyribonuclease VII activity
SYN6312_RS10865	COG0066	3-isopropylmalate dehydratase activity
SYN6312_RS10870	COG3842	ATPase activity
SYN6312_RS10900	COG1192	Involved in chromosome partitioning
SYN6312_RS10910	COG4636	protein conserved in cyanobacteria
SYN6312_RS10915	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYN6312_RS10930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYN6312_RS10950	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
SYN6312_RS10955	COG1492	cobalamin metabolic process
SYN6312_RS10965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYN6312_RS10970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYN6312_RS11010	COG0745	RESPONSE REGULATOR receiver
SYN6312_RS11015	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SYN6312_RS11035	COG0072	phenylalanine-tRNA ligase activity
SYN6312_RS11035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYN6312_RS11050	COG1937	Protein conserved in bacteria
SYN6312_RS11070	COG3046	protein related to deoxyribodipyrimidine photolyase
SYN6312_RS11080	COG0583	DNA-binding transcription factor activity
SYN6312_RS11085	COG1131	(ABC) transporter
SYN6312_RS11090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYN6312_RS11100	COG1216	Glycosyl transferase, family 2
SYN6312_RS11100	COG0463	Glycosyl transferase, family 2
SYN6312_RS11110	COG0297	glycogen (starch) synthase activity
SYN6312_RS11120	COG0438	transferase activity, transferring glycosyl groups
SYN6312_RS11130	COG0297	glycogen (starch) synthase activity
SYN6312_RS11135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYN6312_RS11135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SYN6312_RS11140	COG0084	hydrolase, TatD family'
SYN6312_RS11145	COG0268	Binds directly to 16S ribosomal RNA
SYN6312_RS11160	COG1716	ATPase activity
SYN6312_RS11160	COG1131	(ABC) transporter
SYN6312_RS11160	COG0842	Transport permease protein
SYN6312_RS11165	COG0107	imidazoleglycerol-phosphate synthase activity
SYN6312_RS11170	COG0328	RNA-DNA hybrid ribonuclease activity
SYN6312_RS11170	COG3341	Caulimovirus viroplasmin
SYN6312_RS11175	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SYN6312_RS11180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SYN6312_RS11185	COG0804	urea catabolic process
SYN6312_RS11205	COG2885	chlorophyll binding
SYN6312_RS11210	COG2885	chlorophyll binding
SYN6312_RS11220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SYN6312_RS11225	COG0114	fumarate hydratase activity
SYN6312_RS11245	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYN6312_RS11250	COG1672	PFAM Archaeal ATPase
SYN6312_RS11280	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SYN6312_RS11285	COG0477	Major facilitator Superfamily
SYN6312_RS11290	COG1381	Involved in DNA repair and RecF pathway recombination
SYN6312_RS11310	COG1132	(ABC) transporter
SYN6312_RS11335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYN6312_RS11360	COG1968	undecaprenyl-diphosphatase activity
SYN6312_RS11375	COG1530	ribonuclease E activity
SYN6312_RS11400	COG1489	DNA binding
SYN6312_RS11415	COG0326	Molecular chaperone. Has ATPase activity
SYN6312_RS11445	COG0105	UTP biosynthetic process
SYN6312_RS11450	COG0861	Integral membrane protein TerC family
SYN6312_RS11475	COG2814	Major facilitator Superfamily
SYN6312_RS11490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SYN6312_RS11495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYN6312_RS11515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SYN6312_RS11520	COG0148	phosphopyruvate hydratase activity
SYN6312_RS11530	COG0686	Belongs to the AlaDH PNT family
SYN6312_RS11540	COG0003	Pfam Anion-transporting ATPase
SYN6312_RS11550	COG0180	Tryptophanyl-tRNA synthetase
SYN6312_RS11555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SYN6312_RS11570	COG0641	radical SAM
SYN6312_RS11575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYN6312_RS11580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYN6312_RS11585	COG1595	DNA-templated transcription, initiation
SYN6312_RS11605	COG1305	Transglutaminase-like
SYN6312_RS11630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYN6312_RS11635	COG3937	granule-associated protein
SYN6312_RS11640	COG0149	triose-phosphate isomerase activity
SYN6312_RS11645	COG0131	Imidazoleglycerol-phosphate dehydratase
SYN6312_RS11660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYN6312_RS11660	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYN6312_RS11675	COG0719	Fe-S assembly protein
SYN6312_RS11685	COG2894	cell division
SYN6312_RS11690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SYN6312_RS11695	COG0395	ABC-type sugar transport system, permease component
SYN6312_RS11710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYN6312_RS11715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYN6312_RS11740	COG0646	methionine synthase
SYN6312_RS11740	COG1410	methionine synthase
SYN6312_RS11755	COG1598	PFAM Uncharacterised protein family UPF0150
SYN6312_RS11770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYN6312_RS11780	COG2361	Protein of unknown function DUF86
SYN6312_RS11785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYN6312_RS11795	COG4968	Prepilin-type N-terminal cleavage methylation domain
SYN6312_RS11805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SYN6312_RS11815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYN6312_RS11825	COG0569	domain protein
SYN6312_RS11855	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYN6312_RS11860	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SYN6312_RS11870	COG0824	Thioesterase
SYN6312_RS11880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SYN6312_RS11890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SYN6312_RS11895	COG1799	cell septum assembly
SYN6312_RS11900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SYN6312_RS11905	COG0018	arginyl-trna synthetase
SYN6312_RS11940	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN6312_RS11950	COG0237	dephospho-CoA kinase activity
SYN6312_RS11955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYN6312_RS11960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYN6312_RS11965	COG1413	lyase activity
SYN6312_RS11970	COG1413	lyase activity
SYN6312_RS11975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SYN6312_RS11980	COG0237	dephospho-CoA kinase activity
SYN6312_RS11995	COG1725	Transcriptional regulator
SYN6312_RS12000	COG0523	cobalamin synthesis protein
SYN6312_RS12020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYN6312_RS12035	COG0006	proline dipeptidase activity
SYN6312_RS12045	COG0372	Belongs to the citrate synthase family
SYN6312_RS12050	COG0151	Belongs to the GarS family
SYN6312_RS12055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYN6312_RS12070	COG0484	heat shock protein binding
SYN6312_RS12075	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SYN6312_RS12080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SYN6312_RS12090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SYN6312_RS12120	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SYN6312_RS12125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYN6312_RS12155	COG0156	8-amino-7-oxononanoate synthase activity
SYN6312_RS12190	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SYN6312_RS12200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SYN6312_RS12230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SYN6312_RS12235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SYN6312_RS12240	COG1234	tRNA 3'-trailer cleavage
SYN6312_RS12240	COG1555	photosystem II stabilization
SYN6312_RS12255	COG0411	ABC transporter
SYN6312_RS12265	COG0406	alpha-ribazole phosphatase activity
SYN6312_RS12290	COG1959	2 iron, 2 sulfur cluster binding
SYN6312_RS12295	COG0681	Belongs to the peptidase S26 family
SYN6312_RS12300	COG3932	Exopolysaccharide synthesis, ExoD
SYN6312_RS12320	COG2954	triphosphatase activity
SYN6312_RS12345	COG0653	protein targeting
SYN6312_RS12355	COG1994	Peptidase M50
SYN6312_RS12355	COG0517	IMP dehydrogenase activity
SYN6312_RS12370	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SYN6312_RS12380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN6312_RS12405	COG0753	catalase activity
SYN6312_RS12410	COG0525	valine-tRNA ligase activity
SYN6312_RS12445	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SYN6312_RS12455	COG2912	Transglutaminase-like superfamily
SYN6312_RS12490	COG0305	Participates in initiation and elongation during chromosome replication
SYN6312_RS12490	COG1372	Participates in initiation and elongation during chromosome replication
SYN6312_RS12490	COG1372	Participates in initiation and elongation during chromosome replication
SYN6312_RS12490	COG0305	Participates in initiation and elongation during chromosome replication
SYN6312_RS12495	COG0359	binds to the 23S rRNA
SYN6312_RS12500	COG0799	negative regulation of ribosome biogenesis
SYN6312_RS12505	COG1713	HD superfamily hydrolase involved in NAD metabolism
SYN6312_RS12510	COG0515	serine threonine protein kinase
SYN6312_RS12510	COG1357	PFAM Pentapeptide repeats (8 copies)
SYN6312_RS12515	COG5002	protein histidine kinase activity
SYN6312_RS12520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SYN6312_RS12530	COG0681	Belongs to the peptidase S26 family
SYN6312_RS12535	COG1070	Carbohydrate kinase
SYN6312_RS12545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SYN6312_RS12555	COG0625	glutathione transferase activity
SYN6312_RS12560	COG3795	YCII-related domain
SYN6312_RS12565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYN6312_RS12570	COG1842	Phage shock protein A
SYN6312_RS12575	COG3659	wide pore channel activity
SYN6312_RS12580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYN6312_RS12585	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SYN6312_RS12590	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SYN6312_RS12595	COG4208	sulfate ABC transporter
SYN6312_RS12600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SYN6312_RS12605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYN6312_RS12610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYN6312_RS12615	COG1045	serine acetyltransferase
SYN6312_RS12620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYN6312_RS12625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYN6312_RS12645	COG0728	peptidoglycan biosynthetic process
SYN6312_RS12655	COG0582	viral genome integration into host DNA
SYN6312_RS12665	COG5002	protein histidine kinase activity
SYN6312_RS12665	COG2205	protein histidine kinase activity
SYN6312_RS12665	COG0784	Response regulator, receiver
SYN6312_RS12670	COG2770	Histidine kinase
SYN6312_RS12670	COG2208	phosphoserine phosphatase activity
SYN6312_RS12680	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SYN6312_RS12710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYN6312_RS12720	COG2062	phosphohistidine phosphatase, SixA
SYN6312_RS12735	COG1253	flavin adenine dinucleotide binding
SYN6312_RS12755	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYN6312_RS12760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYN6312_RS12775	COG1132	(ABC) transporter
SYN6312_RS12780	COG1045	serine acetyltransferase
SYN6312_RS12795	COG1216	Glycosyl transferase, family 2
SYN6312_RS12805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SYN6312_RS12840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SYN6312_RS12855	COG0747	negative chemotaxis
SYN6312_RS12860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SYN6312_RS12880	COG0237	dephospho-CoA kinase activity
SYN6312_RS12890	COG0438	transferase activity, transferring glycosyl groups
SYN6312_RS12905	COG0628	permease
SYN6312_RS12910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SYN6312_RS12915	COG2264	protein methyltransferase activity
SYN6312_RS12935	COG0791	NLP P60 protein
SYN6312_RS12935	COG0741	lytic transglycosylase activity
SYN6312_RS12945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SYN6312_RS13040	COG5002	protein histidine kinase activity
SYN6312_RS13045	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SYN6312_RS13060	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SYN6312_RS13070	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SYN6312_RS13075	COG2205	protein histidine kinase activity
SYN6312_RS13080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SYN6312_RS13095	COG0745	RESPONSE REGULATOR receiver
SYN6312_RS13100	COG0598	Magnesium transport protein CorA
SYN6312_RS13105	COG3118	belongs to the thioredoxin family
SYN6312_RS13130	COG0179	Fumarylacetoacetate (FAA) hydrolase
SYN6312_RS13135	COG0360	Binds together with S18 to 16S ribosomal RNA
SYN6312_RS13195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYN6312_RS13220	COG0514	ATP-dependent DNA helicase (RecQ)
SYN6312_RS13365	COG0640	Transcriptional regulator
SYN6312_RS13370	COG2217	Heavy metal translocating P-type atpase
SYN6312_RS13375	COG0789	Transcriptional regulator
SYN6312_RS13455	COG3177	Filamentation induced by cAMP protein fic
SYN6312_RS13460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYN6312_RS13485	COG0484	heat shock protein binding
SYN6312_RS13525	COG3548	integral membrane protein
SYN6312_RS13645	COG1468	defense response to virus
SYN6312_RS13645	COG1518	maintenance of DNA repeat elements
SYN6312_RS13695	COG0484	heat shock protein binding
SYN6312_RS13895	COG2203	Gaf domain
SYN6312_RS13895	COG3706	GGDEF domain
SYN6312_RS13895	COG4251	negative regulation of phosphorylation
SYN6312_RS13895	COG5001	Diguanylate cyclase
SYN6312_RS13900	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SYN6312_RS13920	COG0067	glutamate synthase
SYN6312_RS13920	COG0069	glutamate synthase activity
SYN6312_RS13920	COG0070	glutamate synthase
SYN6312_RS13930	COG0375	protein maturation
SYN6312_RS13940	COG0010	Belongs to the arginase family
SYN6312_RS13960	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYN6312_RS13990	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SYN6312_RS13995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SYN6312_RS14000	COG3409	Peptidoglycan-binding domain 1 protein
SYN6312_RS14000	COG3429	Glucose-6-phosphate dehydrogenase subunit
SYN6312_RS14030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYN6312_RS14035	COG2226	methyltransferase
SYN6312_RS14040	COG1104	cysteine desulfurase activity
SYN6312_RS14050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SYN6312_RS14060	COG1122	ATPase activity
SYN6312_RS14070	COG2226	methyltransferase
SYN6312_RS14075	COG0848	biopolymer transport protein
SYN6312_RS14080	COG0811	peptide transport
SYN6312_RS14090	COG1429	ligase activity, forming nitrogen-metal bonds
SYN6312_RS14095	COG0464	growth
SYN6312_RS14100	COG1404	Belongs to the peptidase S8 family
SYN6312_RS14130	COG3848	Pyruvate phosphate dikinase
SYN6312_RS14130	COG0574	Belongs to the PEP-utilizing enzyme family
SYN6312_RS14140	COG0730	response to heat
SYN6312_RS14145	COG0786	glutamate:sodium symporter activity
SYN6312_RS14190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SYN6312_RS14205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYN6312_RS14210	COG0528	UMP kinase activity
SYN6312_RS14215	COG0233	cytoplasmic translational termination
SYN6312_RS14225	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SYN6312_RS14230	COG1049	propionate catabolic process, 2-methylcitrate cycle
SYN6312_RS14280	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SYN6312_RS14280	COG0646	methionine synthase
SYN6312_RS14285	COG2211	Major facilitator Superfamily
SYN6312_RS14295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SYN6312_RS14310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYN6312_RS14345	COG1006	Multisubunit Na H antiporter MnhC subunit
SYN6312_RS14350	COG0659	secondary active sulfate transmembrane transporter activity
SYN6312_RS14360	COG1063	alcohol dehydrogenase
SYN6312_RS14375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYN6312_RS14380	COG0573	inorganic phosphate transmembrane transporter activity
SYN6312_RS14390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYN6312_RS14475	COG0174	glutamine synthetase
SYN6312_RS14490	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SYN6312_RS14500	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SYN6312_RS14520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SYN6312_RS14520	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SYN6312_RS14525	COG0515	serine threonine protein kinase
SYN6312_RS14535	COG1982	Orn Lys Arg decarboxylase major
SYN6312_RS14555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYN6312_RS14560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYN6312_RS14585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SYN6312_RS14605	COG0017	Asparaginyl-tRNA synthetase
SYN6312_RS14610	COG5002	protein histidine kinase activity
SYN6312_RS14615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SYN6312_RS14620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SYN6312_RS14625	COG0776	regulation of translation
SYN6312_RS14630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYN6312_RS14635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SYN6312_RS14680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SYN6312_RS14690	COG0724	RNA recognition motif
SYN6312_RS14695	COG0542	response to heat
SYN6312_RS14705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYN6312_RS14705	COG2022	thiamine diphosphate biosynthetic process
SYN6312_RS14715	COG2133	pyrroloquinoline quinone binding
SYN6312_RS14720	COG0542	response to heat
SYN6312_RS14725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SYN6312_RS14730	COG1191	sigma factor activity
SYN6312_RS14740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYN6312_RS14755	COG0768	penicillin binding
SYN6312_RS14785	COG0792	nuclease activity
SYN6312_RS14790	COG0436	Aminotransferase
SYN6312_RS14795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYN6312_RS14805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYN6312_RS14810	COG4251	negative regulation of phosphorylation
SYN6312_RS14825	COG1214	PFAM Peptidase M22, glycoprotease
SYN6312_RS14845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SYN6312_RS14850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYN6312_RS14855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYN6312_RS14860	COG1116	anion transmembrane transporter activity
SYN6312_RS14860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYN6312_RS14865	COG1116	anion transmembrane transporter activity
SYN6312_RS14870	COG5001	Diguanylate cyclase
SYN6312_RS14870	COG1716	ATPase activity
SYN6312_RS14885	COG0484	heat shock protein binding
SYN6312_RS14890	COG0443	Heat shock 70 kDa protein
SYN6312_RS14895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SYN6312_RS14905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYN6312_RS14910	COG4399	Belongs to the UPF0754 family
SYN6312_RS14915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYN6312_RS14920	COG1185	polyribonucleotide nucleotidyltransferase activity
SYN6312_RS14950	COG0330	HflC and HflK could
SYN6312_RS14965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYN6312_RS14990	COG3604	Transcriptional regulator
SYN6312_RS15000	COG2199	diguanylate cyclase activity
SYN6312_RS15000	COG2200	EAL domain
SYN6312_RS15000	COG2203	Gaf domain
SYN6312_RS15020	COG0254	rRNA binding
SYN6312_RS15025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SYN6312_RS15030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SYN6312_RS15035	COG0101	tRNA pseudouridine synthase activity
SYN6312_RS15040	COG0203	ribosomal protein L17
SYN6312_RS15045	COG0202	RNA polymerase activity
SYN6312_RS15050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SYN6312_RS15055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SYN6312_RS15065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SYN6312_RS15070	COG0563	adenylate kinase activity
SYN6312_RS15075	COG0201	protein transport
SYN6312_RS15080	COG0200	Binds to the 23S rRNA
SYN6312_RS15085	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SYN6312_RS15090	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SYN6312_RS15095	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SYN6312_RS15100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SYN6312_RS15105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SYN6312_RS15110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SYN6312_RS15115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SYN6312_RS15120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SYN6312_RS15125	COG0255	Belongs to the universal ribosomal protein uL29 family
SYN6312_RS15130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SYN6312_RS15135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SYN6312_RS15140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SYN6312_RS15145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SYN6312_RS15150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SYN6312_RS15155	COG0089	rRNA binding
SYN6312_RS15160	COG0088	Forms part of the polypeptide exit tunnel
SYN6312_RS15165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SYN6312_RS15175	COG2140	Oxalate decarboxylase
SYN6312_RS15190	COG2308	Evidence 4 Homologs of previously reported genes of
SYN6312_RS15210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYN6312_RS15220	COG0259	pyridoxamine-phosphate oxidase activity
SYN6312_RS15230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SYN6312_RS15230	COG0475	glutathione-regulated potassium exporter activity
SYN6312_RS15255	COG0747	negative chemotaxis
SYN6312_RS15265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SYN6312_RS15275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYN6312_RS15285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYN6312_RS15310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SYN6312_RS15320	COG2119	membrane
SYN6312_RS15330	COG1691	(AIR) carboxylase
SYN6312_RS15335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYN6312_RS15355	COG1032	radical SAM domain protein
SYN6312_RS15370	COG1573	uracil-dna glycosylase
SYN6312_RS15375	COG0483	inositol monophosphate 1-phosphatase activity
SYN6312_RS15395	COG1121	(ABC) transporter
SYN6312_RS15400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYN6312_RS15405	COG0440	acetolactate synthase activity
SYN6312_RS15415	COG0745	RESPONSE REGULATOR receiver
SYN6312_RS15420	COG5002	protein histidine kinase activity
SYN6312_RS15425	COG1187	pseudouridine synthase activity
SYN6312_RS15440	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SYN6312_RS15465	COG1058	Belongs to the CinA family
SYN6312_RS15465	COG1546	Belongs to the CinA family
SYN6312_RS15470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYN6312_RS15475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SYN6312_RS15485	COG0366	Alpha amylase catalytic
SYN6312_RS15510	COG1543	Belongs to the glycosyl hydrolase 57 family
SYN6312_RS15515	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SYN6312_RS15520	COG3659	wide pore channel activity
SYN6312_RS15530	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SYN6312_RS15540	COG0519	Catalyzes the synthesis of GMP from XMP
SYN6312_RS15540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SYN6312_RS15545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SYN6312_RS15550	COG0321	lipoyl(octanoyl) transferase activity
SYN6312_RS15555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYN6312_RS15565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYN6312_RS15580	COG0038	chloride channel
SYN6312_RS15595	COG0116	Belongs to the methyltransferase superfamily
SYN6312_RS15620	COG0025	NhaP-type Na H and K H
SYN6312_RS15625	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SYN6312_RS15645	COG1473	amidohydrolase
SYN6312_RS15660	COG0137	argininosuccinate synthase activity
SYN6312_RS15675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SYN6312_RS15680	COG0740	serine-type endopeptidase activity
SYN6312_RS15700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYN6312_RS15705	COG0587	DNA-directed DNA polymerase activity
SYN6312_RS15710	COG0457	Tetratricopeptide repeat
SYN6312_RS15720	COG1899	peptidyl-lysine modification to peptidyl-hypusine
SYN6312_RS15750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SYN6312_RS15790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SYN6312_RS15820	COG2205	protein histidine kinase activity
SYN6312_RS15835	COG0012	GTP binding
SYN6312_RS15845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYN6312_RS15950	COG1106	Psort location Cytoplasmic, score
SYN6312_RS15955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYN6312_RS15990	COG0582	viral genome integration into host DNA
SYN6312_RS16005	COG0745	RESPONSE REGULATOR receiver
SYN6312_RS16020	COG2211	Major facilitator Superfamily
SYN6312_RS16030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYN6312_RS16050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SYN6312_RS16065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYN6312_RS16080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SYN6312_RS16090	COG0174	glutamine synthetase
SYN6312_RS16100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYN6312_RS16115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYN6312_RS16130	COG1420	regulation of RNA biosynthetic process
SYN6312_RS16135	COG0556	nucleotide-excision repair
SYN6312_RS16155	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SYN6312_RS16165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SYN6312_RS16170	COG0297	glycogen (starch) synthase activity
SYN6312_RS16185	COG3118	belongs to the thioredoxin family
SYN6312_RS16205	COG1803	Methylglyoxal synthase
SYN6312_RS16205	COG1597	lipid kinase activity
SYN6312_RS16215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SYN6312_RS16225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYN6312_RS16235	COG0242	peptide deformylase activity
SYN6312_RS16240	COG0438	transferase activity, transferring glycosyl groups
SYN6312_RS16255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SYN6312_RS16260	COG0511	ligase activity, forming carbon-carbon bonds
SYN6312_RS16275	COG4783	chaperone-mediated protein folding
SYN6312_RS16285	COG4172	Belongs to the ABC transporter superfamily
SYN6312_RS16295	COG0454	-acetyltransferase
SYN6312_RS16310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYN6312_RS16320	COG0077	Prephenate dehydratase
SYN6312_RS16345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SYN6312_RS16345	COG0574	Belongs to the PEP-utilizing enzyme family
SYN6312_RS16350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYN6312_RS16355	COG3956	TIGRFAM MazG family protein
SYN6312_RS16365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYN6312_RS16375	COG1132	(ABC) transporter
SYN6312_RS16400	COG0505	Belongs to the CarA family
SYN6312_RS16415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SYN6312_RS16420	COG0724	RNA recognition motif
SYN6312_RS16425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYN6312_RS16445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYN6312_RS16450	COG1252	NADH dehydrogenase
SYN6312_RS16460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYN6312_RS16470	COG0481	GTPase activity
SYN6312_RS16480	COG1056	cytidyltransferase-related domain
SYN6312_RS16480	COG1051	belongs to the nudix hydrolase family
SYN6312_RS16485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SYN6312_RS16490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SYN6312_RS16495	COG0024	Methionine aminopeptidase
SYN6312_RS16500	COG0701	Predicted permease
SYN6312_RS16510	COG0271	Belongs to the BolA IbaG family
SYN6312_RS16525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYN6312_RS16525	COG0237	dephospho-CoA kinase activity
SYN6312_RS16535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYN6312_RS16540	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYN6312_RS16550	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SYN6312_RS16555	COG1598	PFAM Uncharacterised protein family UPF0150
SYN6312_RS16570	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SYN6312_RS16580	COG0484	heat shock protein binding
SYN6312_RS16585	COG0517	IMP dehydrogenase activity
SYN6312_RS16585	COG0516	GMP reductase activity
SYN6312_RS16595	COG0616	signal peptide processing
SYN6312_RS16615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SYN6312_RS16620	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SYN6312_RS16630	COG2252	PERMEase
SYN6312_RS16655	COG1361	Conserved repeat domain
SYN6312_RS16665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SYN6312_RS16670	COG0443	Heat shock 70 kDa protein
SYN6312_RS16675	COG0463	Glycosyl transferase, family 2
SYN6312_RS16695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYN6312_RS16700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYN6312_RS16705	COG4636	protein conserved in cyanobacteria
SYN6312_RS16760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYN6312_RS16770	COG0482	sulfurtransferase activity
SYN6312_RS16775	COG0697	spore germination
SYN6312_RS16795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SYN6312_RS16800	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYN6312_RS16830	COG0140	phosphoribosyl-ATP diphosphatase activity
SYN6312_RS16830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SYN6312_RS16860	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SYN6312_RS16865	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYN6312_RS16870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SYN6312_RS16885	COG0741	lytic transglycosylase activity
SYN6312_RS16890	COG0708	Exodeoxyribonuclease III
SYN6312_RS16900	COG0450	alkyl hydroperoxide reductase
SYN6312_RS16925	COG0740	serine-type endopeptidase activity
SYN6312_RS16960	COG0702	epimerase
SYN6312_RS16965	COG1040	competence protein
SYN6312_RS16970	COG0336	Belongs to the RNA methyltransferase TrmD family
SYN6312_RS16975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SYN6312_RS16980	COG2205	protein histidine kinase activity
SYN6312_RS16990	COG1063	alcohol dehydrogenase
SYN6312_RS16995	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SYN6312_RS17005	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SYN6312_RS17025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SYN6312_RS17035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SYN6312_RS17040	COG0429	hydrolase of the alpha beta-hydrolase fold
SYN6312_RS17050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYN6312_RS17060	COG0573	inorganic phosphate transmembrane transporter activity
SYN6312_RS17065	COG0581	inorganic phosphate transmembrane transporter activity
SYN6312_RS17070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYN6312_RS17075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYN6312_RS17075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYN6312_RS17090	COG0460	homoserine dehydrogenase
SYN6312_RS17095	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SYN6312_RS17095	COG3264	Mechanosensitive ion channel
SYN6312_RS17105	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SYN6312_RS17110	COG1304	FMN binding
SYN6312_RS17130	COG0793	Belongs to the peptidase S41A family
SYN6312_RS17140	COG1078	dGTPase activity
SYN6312_RS17150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SYN6312_RS17180	COG2205	protein histidine kinase activity
SYN6312_RS17180	COG2202	Pas domain
SYN6312_RS17185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SYN6312_RS17210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SYN6312_RS17215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SYN6312_RS17225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SYN6312_RS17240	COG1136	(ABC) transporter
SYN6312_RS17240	COG0577	efflux transmembrane transporter activity
SYN6312_RS17250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SYN6312_RS17255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYN6312_RS17275	COG0316	Belongs to the HesB IscA family
SYN6312_RS17280	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SYN6312_RS17280	COG0662	Cupin 2, conserved barrel domain protein
SYN6312_RS17295	COG4956	integral membrane protein (PIN domain superfamily)
SYN6312_RS17305	COG0420	3'-5' exonuclease activity
SYN6312_RS17325	COG0456	acetyltransferase
SYN6312_RS17335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYN6312_RS17350	COG0415	Belongs to the DNA photolyase family
SYN6312_RS17355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYN6312_RS17360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SYN6312_RS17405	COG4106	trans-aconitate 2-methyltransferase activity
SYN6312_RS17410	COG3781	membrane
SYN6312_RS17415	COG0157	Belongs to the NadC ModD family
SYN6312_RS17420	COG0583	DNA-binding transcription factor activity
SYN6312_RS17430	COG0412	Dienelactone hydrolase
SYN6312_RS17440	COG1028	Short-chain dehydrogenase reductase Sdr
SYN6312_RS17445	COG0312	modulator of DNA gyrase
SYN6312_RS17455	COG0784	Response regulator, receiver
SYN6312_RS17470	COG0840	transmembrane signaling receptor activity
SYN6312_RS17470	COG2203	Gaf domain
SYN6312_RS17490	COG1472	Belongs to the glycosyl hydrolase 3 family
SYN6312_RS17520	COG0704	Plays a role in the regulation of phosphate uptake
SYN6312_RS17525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SYN6312_RS17530	COG0740	serine-type endopeptidase activity
SYN6312_RS17535	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYN6312_RS17565	COG0228	four-way junction DNA binding
SYN6312_RS17575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SYN6312_RS17580	COG1702	phosphate starvation-inducible protein PhoH
SYN6312_RS17595	COG1131	(ABC) transporter
SYN6312_RS17600	COG0542	response to heat
SYN6312_RS17620	COG0277	FAD linked oxidase domain protein
SYN6312_RS17640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SYN6312_RS17645	COG0850	regulation of cytokinetic process
SYN6312_RS17655	COG2319	Wd-40 repeat
SYN6312_RS17655	COG3903	Transcriptional regulator
SYN6312_RS17670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYN6312_RS17670	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYN6312_RS17675	COG1615	UPF0182 protein
SYN6312_RS17680	COG3527	Alpha-acetolactate decarboxylase
SYN6312_RS17705	COG0492	ferredoxin-NADP+ reductase activity
SYN6312_RS17720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SYN6312_RS17755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SYN6312_RS17760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SYN6312_RS17765	COG0058	SHG alpha-glucan phosphorylase activity
SYN6312_RS17770	COG0456	acetyltransferase
SYN6312_RS17780	COG0454	-acetyltransferase
SYN6312_RS17800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SYN6312_RS17805	COG0189	ligase activity
SYN6312_RS17830	COG0778	Nitroreductase
SYN6312_RS17840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SYN6312_RS17850	COG0163	prenyltransferase activity
SYN6312_RS17860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SYN6312_RS17875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYN6312_RS17895	COG0706	membrane insertase activity
SYN6312_RS17905	COG0594	ribonuclease P activity
SYN6312_RS17955	COG0750	zinc metalloprotease
SYN6312_RS18065	COG2205	protein histidine kinase activity
SYN6312_RS18065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYN6312_RS18070	COG5002	protein histidine kinase activity
SYN6312_RS18115	COG2203	Gaf domain
SYN6312_RS18115	COG5001	Diguanylate cyclase
SYN6312_RS18115	COG4251	negative regulation of phosphorylation
SYN6312_RS18115	COG3706	GGDEF domain
SYN6312_RS18130	COG0457	Tetratricopeptide repeat
SYN6312_RS18130	COG0463	Glycosyl transferase, family 2
SYN6312_RS18145	COG0784	Response regulator, receiver
SYN6312_RS18145	COG5002	protein histidine kinase activity
SYN6312_RS18145	COG2205	protein histidine kinase activity
SYN6312_RS18150	COG1136	(ABC) transporter
SYN6312_RS18155	COG0110	maltose O-acetyltransferase activity
SYN6312_RS18170	COG0653	protein targeting
SYN6312_RS18230	COG2369	cell adhesion
SYN6312_RS18235	COG5005	Phage virion morphogenesis
SYN6312_RS18250	COG1797	cobyrinic acid a,c-diamide synthase activity
SYN6312_RS18255	COG5001	Diguanylate cyclase
SYN6312_RS18255	COG4251	negative regulation of phosphorylation
SYN6312_RS18255	COG3706	GGDEF domain
SYN6312_RS18255	COG2203	Gaf domain
SYN6312_RS18260	COG3385	transposase activity
SYN6312_RS18270	COG2385	sporulation resulting in formation of a cellular spore
SYN6312_RS18285	COG5001	Diguanylate cyclase
SYN6312_RS18285	COG4251	negative regulation of phosphorylation
SYN6312_RS18285	COG3706	GGDEF domain
SYN6312_RS18285	COG2203	Gaf domain
SYN6312_RS18290	COG1357	PFAM Pentapeptide repeats (8 copies)
SYN6312_RS18290	COG0515	serine threonine protein kinase
SYN6312_RS18295	COG1216	Glycosyl transferase, family 2
SYN6312_RS18340	COG0457	Tetratricopeptide repeat
SYN6312_RS18340	COG0463	Glycosyl transferase, family 2
SYN6312_RS18380	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SYN6312_RS18380	COG2273	Hydrolase Family 16
SYN6312_RS18405	COG1705	Flagellar rod assembly protein muramidase FlgJ
SYN6312_RS18405	COG3951	Flagellar rod assembly protein muramidase FlgJ
SYN6312_RS18450	COG0456	acetyltransferase
SYN6312_RS18535	COG1648	precorrin-2 dehydrogenase activity
SYN6312_RS18535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYN6312_RS18540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYN6312_RS18550	COG2203	Gaf domain
SYN6312_RS18550	COG4251	negative regulation of phosphorylation
SYN6312_RS18550	COG5001	Diguanylate cyclase
SYN6312_RS18550	COG3706	GGDEF domain
SYN6312_RS18575	COG1357	PFAM Pentapeptide repeats (8 copies)
SYN6312_RS18575	COG0515	serine threonine protein kinase
SYN6312_RS18585	COG3437	response regulator, receiver
SYN6312_RS18585	COG4999	Histidine kinase
SYN6312_RS18585	COG2205	protein histidine kinase activity
SYN6312_RS18585	COG3850	Histidine kinase