locus-tag	class	description
SynPROSU1_RS00005	COG0592	DNA-directed DNA polymerase activity
SynPROSU1_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynPROSU1_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynPROSU1_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynPROSU1_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynPROSU1_RS00055	COG0552	protein localization to endoplasmic reticulum
SynPROSU1_RS00060	COG2208	phosphoserine phosphatase activity
SynPROSU1_RS00065	COG0165	Argininosuccinate lyase
SynPROSU1_RS00070	COG0724	RNA recognition motif
SynPROSU1_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynPROSU1_RS00085	COG2081	HI0933 family
SynPROSU1_RS00090	COG1459	type II secretion system
SynPROSU1_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynPROSU1_RS00105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynPROSU1_RS00110	COG0484	heat shock protein binding
SynPROSU1_RS00120	COG1162	GTPase activity
SynPROSU1_RS00125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynPROSU1_RS00130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynPROSU1_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynPROSU1_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynPROSU1_RS00145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynPROSU1_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROSU1_RS00155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynPROSU1_RS00160	COG0511	ligase activity, forming carbon-carbon bonds
SynPROSU1_RS00165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynPROSU1_RS00225	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynPROSU1_RS00230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynPROSU1_RS00230	COG0519	Catalyzes the synthesis of GMP from XMP
SynPROSU1_RS00250	COG0768	penicillin binding
SynPROSU1_RS00260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynPROSU1_RS00260	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_RS00265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynPROSU1_RS00275	COG2022	thiamine diphosphate biosynthetic process
SynPROSU1_RS00290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynPROSU1_RS00295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynPROSU1_RS00300	COG2385	sporulation resulting in formation of a cellular spore
SynPROSU1_RS00305	COG1215	transferase activity, transferring glycosyl groups
SynPROSU1_RS00310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynPROSU1_RS00320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynPROSU1_RS00325	COG0740	serine-type endopeptidase activity
SynPROSU1_RS00330	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynPROSU1_RS00335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynPROSU1_RS00340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynPROSU1_RS00345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynPROSU1_RS00385	COG2082	Precorrin-8x methylmutase
SynPROSU1_RS00395	COG0037	tRNA processing
SynPROSU1_RS00410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynPROSU1_RS00430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynPROSU1_RS00445	COG0556	nucleotide-excision repair
SynPROSU1_RS00450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynPROSU1_RS00465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynPROSU1_RS00480	COG0436	Aminotransferase
SynPROSU1_RS00485	COG0028	Belongs to the TPP enzyme family
SynPROSU1_RS00490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynPROSU1_RS00570	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_RS00630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynPROSU1_RS00680	COG0653	protein targeting
SynPROSU1_RS00695	COG1045	serine acetyltransferase
SynPROSU1_RS00700	COG1725	Transcriptional regulator
SynPROSU1_RS00715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynPROSU1_RS00720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynPROSU1_RS00725	COG1372	Participates in initiation and elongation during chromosome replication
SynPROSU1_RS00725	COG0187	DNA topoisomerase II activity
SynPROSU1_RS00735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynPROSU1_RS00740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynPROSU1_RS00750	COG0386	Belongs to the glutathione peroxidase family
SynPROSU1_RS00755	COG2239	Acts as a magnesium transporter
SynPROSU1_RS00760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_RS00765	COG0596	Alpha beta hydrolase
SynPROSU1_RS00775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynPROSU1_RS00835	COG1194	a g-specific adenine glycosylase
SynPROSU1_RS00850	COG0802	atpase or kinase
SynPROSU1_RS00855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynPROSU1_RS00860	COG0586	Pfam SNARE associated Golgi protein
SynPROSU1_RS00865	COG0629	single-stranded DNA binding
SynPROSU1_RS00875	COG1792	Involved in formation and maintenance of cell shape
SynPROSU1_RS00895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynPROSU1_RS00915	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynPROSU1_RS00920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynPROSU1_RS00925	COG0515	serine threonine protein kinase
SynPROSU1_RS00930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynPROSU1_RS00935	COG2255	four-way junction helicase activity
SynPROSU1_RS00945	COG1473	amidohydrolase
SynPROSU1_RS00960	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynPROSU1_RS00965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynPROSU1_RS00970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynPROSU1_RS00975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynPROSU1_RS00980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_RS00985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynPROSU1_RS00990	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynPROSU1_RS00990	COG0662	Cupin 2, conserved barrel domain protein
SynPROSU1_RS00995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynPROSU1_RS01005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROSU1_RS01010	COG0571	ribonuclease III activity
SynPROSU1_RS01035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynPROSU1_RS01040	COG0058	SHG alpha-glucan phosphorylase activity
SynPROSU1_RS01045	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SynPROSU1_RS01050	COG0475	glutathione-regulated potassium exporter activity
SynPROSU1_RS01070	COG0277	FAD linked oxidase domain protein
SynPROSU1_RS01080	COG0247	lactate metabolic process
SynPROSU1_RS01085	COG0538	isocitrate dehydrogenase activity
SynPROSU1_RS01090	COG0463	Glycosyl transferase, family 2
SynPROSU1_RS01100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SynPROSU1_RS01110	COG5398	heme oxygenase
SynPROSU1_RS01120	COG1132	(ABC) transporter
SynPROSU1_RS01125	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_RS01130	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_RS01135	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_RS01140	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_RS01155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynPROSU1_RS01180	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynPROSU1_RS01185	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynPROSU1_RS01190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynPROSU1_RS01195	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynPROSU1_RS01195	COG0517	IMP dehydrogenase activity
SynPROSU1_RS01200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynPROSU1_RS01200	COG0617	tRNA 3'-terminal CCA addition
SynPROSU1_RS01200	COG0517	IMP dehydrogenase activity
SynPROSU1_RS01210	COG0709	Synthesizes selenophosphate from selenide and ATP
SynPROSU1_RS01215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynPROSU1_RS01225	COG2274	protein secretion by the type I secretion system
SynPROSU1_RS01240	COG0124	histidyl-tRNA synthetase
SynPROSU1_RS01250	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynPROSU1_RS01280	COG4447	cellulose binding
SynPROSU1_RS01285	COG1773	rubredoxin
SynPROSU1_RS01290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_RS01295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_RS01300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_RS01305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynPROSU1_RS01310	COG3842	ATPase activity
SynPROSU1_RS01320	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROSU1_RS01320	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROSU1_RS01335	COG0494	nUDIX hydrolase
SynPROSU1_RS01340	COG0415	Belongs to the DNA photolyase family
SynPROSU1_RS01370	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynPROSU1_RS01375	COG0131	Imidazoleglycerol-phosphate dehydratase
SynPROSU1_RS01380	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynPROSU1_RS01395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynPROSU1_RS01415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynPROSU1_RS01420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynPROSU1_RS01430	COG0354	folic acid binding
SynPROSU1_RS01435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynPROSU1_RS01450	COG1253	flavin adenine dinucleotide binding
SynPROSU1_RS01455	COG0673	inositol 2-dehydrogenase activity
SynPROSU1_RS01465	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SynPROSU1_RS01475	COG0343	queuine tRNA-ribosyltransferase activity
SynPROSU1_RS01480	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynPROSU1_RS01500	COG0138	bifunctional purine biosynthesis protein purh
SynPROSU1_RS01515	COG0716	FMN binding
SynPROSU1_RS01540	COG0351	phosphomethylpyrimidine kinase
SynPROSU1_RS01550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynPROSU1_RS01555	COG0004	ammonium transporteR
SynPROSU1_RS01560	COG1489	DNA binding
SynPROSU1_RS01565	COG0728	peptidoglycan biosynthetic process
SynPROSU1_RS01590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynPROSU1_RS01595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynPROSU1_RS01600	COG1546	Belongs to the CinA family
SynPROSU1_RS01600	COG1058	Belongs to the CinA family
SynPROSU1_RS01605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynPROSU1_RS01610	COG0066	3-isopropylmalate dehydratase activity
SynPROSU1_RS01645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynPROSU1_RS01650	COG0193	aminoacyl-tRNA hydrolase activity
SynPROSU1_RS01665	COG4372	Transposase
SynPROSU1_RS01670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROSU1_RS01675	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynPROSU1_RS01685	COG0717	Belongs to the dCTP deaminase family
SynPROSU1_RS01695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynPROSU1_RS01705	COG0741	lytic transglycosylase activity
SynPROSU1_RS01710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynPROSU1_RS01725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynPROSU1_RS01745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynPROSU1_RS01765	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynPROSU1_RS01770	COG1402	creatininase
SynPROSU1_RS01780	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynPROSU1_RS01785	COG2094	Belongs to the DNA glycosylase MPG family
SynPROSU1_RS01790	COG0540	Belongs to the ATCase OTCase family
SynPROSU1_RS01820	COG3536	Protein conserved in bacteria
SynPROSU1_RS01825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynPROSU1_RS01840	COG2046	Belongs to the sulfate adenylyltransferase family
SynPROSU1_RS01840	COG0529	Catalyzes the synthesis of activated sulfate
SynPROSU1_RS01845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROSU1_RS01860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynPROSU1_RS01890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROSU1_RS01905	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynPROSU1_RS01910	COG0436	Aminotransferase
SynPROSU1_RS01920	COG1530	ribonuclease E activity
SynPROSU1_RS01925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynPROSU1_RS01940	COG2226	methyltransferase
SynPROSU1_RS01945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynPROSU1_RS01950	COG0051	transcription antitermination factor activity, RNA binding
SynPROSU1_RS01955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynPROSU1_RS01960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynPROSU1_RS01965	COG0049	tRNA binding
SynPROSU1_RS01970	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynPROSU1_RS01985	COG0069	glutamate synthase activity
SynPROSU1_RS01985	COG0070	glutamate synthase
SynPROSU1_RS01985	COG0067	glutamate synthase
SynPROSU1_RS02005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynPROSU1_RS02035	COG2885	chlorophyll binding
SynPROSU1_RS02040	COG2885	chlorophyll binding
SynPROSU1_RS02085	COG0463	Glycosyl transferase, family 2
SynPROSU1_RS02115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynPROSU1_RS02125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynPROSU1_RS02130	COG0254	rRNA binding
SynPROSU1_RS02135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynPROSU1_RS02140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynPROSU1_RS02145	COG0101	tRNA pseudouridine synthase activity
SynPROSU1_RS02150	COG0203	ribosomal protein L17
SynPROSU1_RS02155	COG0202	RNA polymerase activity
SynPROSU1_RS02160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynPROSU1_RS02165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynPROSU1_RS02170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynPROSU1_RS02175	COG0563	adenylate kinase activity
SynPROSU1_RS02180	COG0201	protein transport
SynPROSU1_RS02185	COG0200	Binds to the 23S rRNA
SynPROSU1_RS02190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynPROSU1_RS02195	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynPROSU1_RS02200	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynPROSU1_RS02205	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynPROSU1_RS02210	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynPROSU1_RS02215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynPROSU1_RS02220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynPROSU1_RS02225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynPROSU1_RS02230	COG0255	Belongs to the universal ribosomal protein uL29 family
SynPROSU1_RS02235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynPROSU1_RS02240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynPROSU1_RS02245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynPROSU1_RS02250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynPROSU1_RS02255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynPROSU1_RS02260	COG0089	rRNA binding
SynPROSU1_RS02265	COG0088	Forms part of the polypeptide exit tunnel
SynPROSU1_RS02270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynPROSU1_RS02285	COG3854	ATPases associated with a variety of cellular activities
SynPROSU1_RS02300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynPROSU1_RS02330	COG3001	Fructosamine kinase
SynPROSU1_RS02350	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynPROSU1_RS02355	COG1606	tRNA processing
SynPROSU1_RS02360	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynPROSU1_RS02365	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynPROSU1_RS02380	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynPROSU1_RS02385	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynPROSU1_RS02390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynPROSU1_RS02405	COG0772	Belongs to the SEDS family
SynPROSU1_RS02410	COG0489	protein tyrosine kinase activity
SynPROSU1_RS02415	COG0408	coproporphyrinogen oxidase activity
SynPROSU1_RS02435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynPROSU1_RS02475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynPROSU1_RS02480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynPROSU1_RS02485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynPROSU1_RS02485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynPROSU1_RS02490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynPROSU1_RS02660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROSU1_RS02705	COG1070	Carbohydrate kinase
SynPROSU1_RS02710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynPROSU1_RS02715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynPROSU1_RS02720	COG0539	negative regulation of cytoplasmic translation
SynPROSU1_RS02725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynPROSU1_RS02750	COG0589	response to stress
SynPROSU1_RS02760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynPROSU1_RS02760	COG0758	DNA mediated transformation
SynPROSU1_RS02765	COG2890	protein-(glutamine-N5) methyltransferase activity
SynPROSU1_RS02770	COG0009	L-threonylcarbamoyladenylate synthase
SynPROSU1_RS02790	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynPROSU1_RS02795	COG2894	cell division
SynPROSU1_RS02800	COG0850	regulation of cytokinetic process
SynPROSU1_RS02805	COG1078	dGTPase activity
SynPROSU1_RS02810	COG0793	Belongs to the peptidase S41A family
SynPROSU1_RS02815	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynPROSU1_RS02820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynPROSU1_RS02855	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynPROSU1_RS02860	COG0235	Class ii aldolase
SynPROSU1_RS02865	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynPROSU1_RS02870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynPROSU1_RS02885	COG0514	ATP-dependent DNA helicase (RecQ)
SynPROSU1_RS02890	COG3584	3D domain protein
SynPROSU1_RS02890	COG1388	LysM domain
SynPROSU1_RS02895	COG1012	belongs to the aldehyde dehydrogenase family
SynPROSU1_RS02905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynPROSU1_RS02910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynPROSU1_RS02930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynPROSU1_RS02950	COG0659	secondary active sulfate transmembrane transporter activity
SynPROSU1_RS02955	COG4243	Vitamin k epoxide reductase
SynPROSU1_RS02960	COG0484	heat shock protein binding
SynPROSU1_RS02965	COG0113	porphobilinogen synthase activity
SynPROSU1_RS02975	COG1193	negative regulation of DNA recombination
SynPROSU1_RS03005	COG2208	phosphoserine phosphatase activity
SynPROSU1_RS03005	COG2770	Histidine kinase
SynPROSU1_RS03055	COG3842	ATPase activity
SynPROSU1_RS03060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynPROSU1_RS03075	COG0488	(ABC) transporter
SynPROSU1_RS03085	COG0435	Glutathione S-transferase
SynPROSU1_RS03090	COG2988	succinylglutamate desuccinylase activity
SynPROSU1_RS03260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynPROSU1_RS03270	COG1185	polyribonucleotide nucleotidyltransferase activity
SynPROSU1_RS03275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynPROSU1_RS03280	COG0750	zinc metalloprotease
SynPROSU1_RS03285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynPROSU1_RS03305	COG0706	membrane insertase activity
SynPROSU1_RS03315	COG0594	ribonuclease P activity
SynPROSU1_RS03320	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynPROSU1_RS03335	COG0616	signal peptide processing
SynPROSU1_RS03340	COG0697	spore germination
SynPROSU1_RS03350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynPROSU1_RS03365	COG1842	Phage shock protein A
SynPROSU1_RS03370	COG3118	belongs to the thioredoxin family
SynPROSU1_RS03375	COG0436	Aminotransferase
SynPROSU1_RS03380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynPROSU1_RS03380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynPROSU1_RS03385	COG0739	heme binding
SynPROSU1_RS03390	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_RS03400	COG2205	protein histidine kinase activity
SynPROSU1_RS03410	COG0577	efflux transmembrane transporter activity
SynPROSU1_RS03410	COG1136	(ABC) transporter
SynPROSU1_RS03415	COG1007	ATP synthesis coupled electron transport
SynPROSU1_RS03420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynPROSU1_RS03435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynPROSU1_RS03465	COG1845	cytochrome c oxidase, subunit III
SynPROSU1_RS03470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynPROSU1_RS03475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynPROSU1_RS03480	COG1612	heme a metabolic process
SynPROSU1_RS03485	COG0109	protoheme IX farnesyltransferase activity
SynPROSU1_RS03505	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynPROSU1_RS03510	COG0459	protein refolding
SynPROSU1_RS03520	COG1028	Short-chain dehydrogenase reductase Sdr
SynPROSU1_RS03535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynPROSU1_RS03540	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynPROSU1_RS03545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynPROSU1_RS03550	COG0248	Ppx GppA phosphatase
SynPROSU1_RS03570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynPROSU1_RS03575	COG0739	heme binding
SynPROSU1_RS03580	COG0723	plastoquinol--plastocyanin reductase activity
SynPROSU1_RS03590	COG0805	protein transport
SynPROSU1_RS03595	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynPROSU1_RS03600	COG0194	GDP metabolic process
SynPROSU1_RS03615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynPROSU1_RS03620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROSU1_RS03630	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynPROSU1_RS03650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynPROSU1_RS03670	COG0335	large ribosomal subunit rRNA binding
SynPROSU1_RS03680	COG0024	Methionine aminopeptidase
SynPROSU1_RS03685	COG3000	fatty acid hydroxylase
SynPROSU1_RS03685	COG0300	oxidoreductase activity
SynPROSU1_RS03695	COG0857	belongs to the CobB CobQ family
SynPROSU1_RS03715	COG1666	GTP binding
SynPROSU1_RS03730	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynPROSU1_RS03745	COG0295	cytidine deaminase activity
SynPROSU1_RS03755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynPROSU1_RS03760	COG0277	FAD linked oxidase domain protein
SynPROSU1_RS03765	COG0708	Exodeoxyribonuclease III
SynPROSU1_RS03790	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynPROSU1_RS03810	COG3842	ATPase activity
SynPROSU1_RS03820	COG0523	cobalamin synthesis protein
SynPROSU1_RS03825	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynPROSU1_RS03840	COG0432	Pfam Uncharacterised protein family UPF0047
SynPROSU1_RS03850	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynPROSU1_RS03855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynPROSU1_RS03870	COG0181	hydroxymethylbilane synthase activity
SynPROSU1_RS03880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_RS03885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynPROSU1_RS03895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynPROSU1_RS03915	COG2099	Precorrin-6x reductase
SynPROSU1_RS03925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynPROSU1_RS03930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynPROSU1_RS03940	COG0442	prolyl-tRNA aminoacylation
SynPROSU1_RS03950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynPROSU1_RS03980	COG0588	phosphoglycerate mutase activity
SynPROSU1_RS03995	COG0768	penicillin binding
SynPROSU1_RS04000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynPROSU1_RS04015	COG0415	Belongs to the DNA photolyase family
SynPROSU1_RS04025	COG0233	cytoplasmic translational termination
SynPROSU1_RS04030	COG0528	UMP kinase activity
SynPROSU1_RS04055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROSU1_RS04060	COG0028	Belongs to the TPP enzyme family
SynPROSU1_RS04080	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynPROSU1_RS04100	COG0539	negative regulation of cytoplasmic translation
SynPROSU1_RS04110	COG3396	Phenylacetate-CoA oxygenase
SynPROSU1_RS04115	COG5322	oxidoreductase activity
SynPROSU1_RS04120	COG0825	malonyl-CoA metabolic process
SynPROSU1_RS04125	COG0300	oxidoreductase activity
SynPROSU1_RS04130	COG0302	gtp cyclohydrolase
SynPROSU1_RS04135	COG0135	phosphoribosylanthranilate isomerase activity
SynPROSU1_RS04140	COG0517	IMP dehydrogenase activity
SynPROSU1_RS04140	COG1994	Peptidase M50
SynPROSU1_RS04145	COG0095	Lipoate-protein ligase
SynPROSU1_RS04150	COG0730	response to heat
SynPROSU1_RS04180	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynPROSU1_RS04190	COG1231	oxidoreductase activity
SynPROSU1_RS04195	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynPROSU1_RS04200	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynPROSU1_RS04210	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROSU1_RS04215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynPROSU1_RS04220	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROSU1_RS04225	COG1850	ribulose-bisphosphate carboxylase activity
SynPROSU1_RS04230	COG4451	ribulose bisphosphate carboxylase, small
SynPROSU1_RS04255	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROSU1_RS04260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynPROSU1_RS04265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_RS04300	COG1492	cobalamin metabolic process
SynPROSU1_RS04310	COG0424	maF-like protein
SynPROSU1_RS04350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynPROSU1_RS04355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynPROSU1_RS04365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynPROSU1_RS04400	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynPROSU1_RS04405	COG0579	oxidoreductase
SynPROSU1_RS04420	COG0481	GTPase activity
SynPROSU1_RS04445	COG2165	general secretion pathway protein
SynPROSU1_RS04460	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_RS04475	COG4968	Prepilin-type N-terminal cleavage methylation domain
SynPROSU1_RS04490	COG5002	protein histidine kinase activity
SynPROSU1_RS04495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SynPROSU1_RS04510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROSU1_RS04515	COG0545	Peptidyl-prolyl cis-trans isomerase
SynPROSU1_RS04520	COG3695	enzyme binding
SynPROSU1_RS04525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynPROSU1_RS04525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynPROSU1_RS04530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynPROSU1_RS04535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynPROSU1_RS04545	COG0107	imidazoleglycerol-phosphate synthase activity
SynPROSU1_RS04550	COG2226	methyltransferase
SynPROSU1_RS04560	COG0752	glycyl-tRNA synthetase alpha subunit
SynPROSU1_RS04595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynPROSU1_RS04600	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynPROSU1_RS04605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynPROSU1_RS04610	COG0740	serine-type endopeptidase activity
SynPROSU1_RS04615	COG0740	serine-type endopeptidase activity
SynPROSU1_RS04620	COG4956	integral membrane protein (PIN domain superfamily)
SynPROSU1_RS04625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynPROSU1_RS04640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynPROSU1_RS04650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynPROSU1_RS04665	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynPROSU1_RS04670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROSU1_RS04675	COG4948	Mandelate Racemase Muconate Lactonizing
SynPROSU1_RS04710	COG0285	dihydrofolate synthase activity
SynPROSU1_RS04715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynPROSU1_RS04720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynPROSU1_RS04725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynPROSU1_RS04740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROSU1_RS04745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynPROSU1_RS04750	COG0134	indole-3-glycerol-phosphate synthase activity
SynPROSU1_RS04780	COG1007	ATP synthesis coupled electron transport
SynPROSU1_RS04785	COG1006	Multisubunit Na H antiporter MnhC subunit
SynPROSU1_RS04815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynPROSU1_RS04820	COG0482	sulfurtransferase activity
SynPROSU1_RS04825	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynPROSU1_RS04825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynPROSU1_RS04830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_RS04835	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynPROSU1_RS04845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynPROSU1_RS04850	COG0228	four-way junction DNA binding
SynPROSU1_RS04855	COG1702	phosphate starvation-inducible protein PhoH
SynPROSU1_RS04860	COG0670	Belongs to the BI1 family
SynPROSU1_RS04865	COG0477	Major facilitator Superfamily
SynPROSU1_RS04875	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynPROSU1_RS04880	COG0786	glutamate:sodium symporter activity
SynPROSU1_RS04895	COG0336	Belongs to the RNA methyltransferase TrmD family
SynPROSU1_RS04905	COG1691	(AIR) carboxylase
SynPROSU1_RS04925	COG0352	thiamine-phosphate diphosphorylase activity
SynPROSU1_RS04930	COG0196	riboflavin kinase activity
SynPROSU1_RS04945	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynPROSU1_RS04950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynPROSU1_RS04970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynPROSU1_RS04975	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_RS05015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynPROSU1_RS05015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynPROSU1_RS05050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynPROSU1_RS05080	COG2135	peptidase activity
SynPROSU1_RS05090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROSU1_RS05095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynPROSU1_RS05110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynPROSU1_RS05125	COG1611	Belongs to the LOG family
SynPROSU1_RS05130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynPROSU1_RS05150	COG0251	oxidation-reduction process
SynPROSU1_RS05155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynPROSU1_RS05160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynPROSU1_RS05165	COG1132	(ABC) transporter
SynPROSU1_RS05170	COG0456	acetyltransferase
SynPROSU1_RS05185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROSU1_RS05190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynPROSU1_RS05210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynPROSU1_RS05220	COG1845	cytochrome c oxidase, subunit III
SynPROSU1_RS05225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynPROSU1_RS05250	COG0659	secondary active sulfate transmembrane transporter activity
SynPROSU1_RS05255	COG0418	dihydroorotase activity
SynPROSU1_RS05280	COG0159	tryptophan synthase activity
SynPROSU1_RS05295	COG2010	Cytochrome c
SynPROSU1_RS05335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_RS05355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynPROSU1_RS05355	COG0140	phosphoribosyl-ATP diphosphatase activity
SynPROSU1_RS05365	COG0542	response to heat
SynPROSU1_RS05410	COG3794	PFAM blue (type 1) copper domain protein
SynPROSU1_RS05420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynPROSU1_RS05425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynPROSU1_RS05465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynPROSU1_RS05480	COG0339	signal peptide processing
SynPROSU1_RS05485	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_RS05490	COG0083	homoserine kinase activity
SynPROSU1_RS05495	COG0837	glucose binding
SynPROSU1_RS05505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynPROSU1_RS05520	COG0180	Tryptophanyl-tRNA synthetase
SynPROSU1_RS05605	COG0730	response to heat
SynPROSU1_RS05650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynPROSU1_RS05725	COG1116	anion transmembrane transporter activity
SynPROSU1_RS05730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynPROSU1_RS05745	COG0375	protein maturation
SynPROSU1_RS05750	COG0010	Belongs to the arginase family
SynPROSU1_RS05785	COG0484	heat shock protein binding
SynPROSU1_RS05850	COG3239	Fatty acid desaturase
SynPROSU1_RS05855	COG0583	DNA-binding transcription factor activity
SynPROSU1_RS05890	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynPROSU1_RS05895	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynPROSU1_RS05900	COG0798	PFAM Bile acid sodium symporter
SynPROSU1_RS05920	COG0681	Belongs to the peptidase S26 family
SynPROSU1_RS05925	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynPROSU1_RS05930	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynPROSU1_RS05935	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROSU1_RS05940	COG0297	glycogen (starch) synthase activity
SynPROSU1_RS05950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynPROSU1_RS05955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynPROSU1_RS05965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynPROSU1_RS05970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynPROSU1_RS05975	COG2045	Belongs to the ComB family
SynPROSU1_RS05990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynPROSU1_RS05995	COG0142	geranyltranstransferase activity
SynPROSU1_RS06000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynPROSU1_RS06005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynPROSU1_RS06015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROSU1_RS06020	COG2176	DNA-directed DNA polymerase activity
SynPROSU1_RS06040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROSU1_RS06085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROSU1_RS06095	COG1132	(ABC) transporter
SynPROSU1_RS06100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynPROSU1_RS06105	COG0505	Belongs to the CarA family
SynPROSU1_RS06115	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynPROSU1_RS06120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROSU1_RS06130	COG0154	amidase activity
SynPROSU1_RS06140	COG0587	DNA-directed DNA polymerase activity
SynPROSU1_RS06150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynPROSU1_RS06155	COG0632	four-way junction helicase activity
SynPROSU1_RS06170	COG0358	DNA primase activity
SynPROSU1_RS06195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynPROSU1_RS06220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynPROSU1_RS06235	COG0792	nuclease activity
SynPROSU1_RS06240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynPROSU1_RS06245	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynPROSU1_RS06255	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynPROSU1_RS06255	COG0022	dehydrogenase e1 component
SynPROSU1_RS06260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynPROSU1_RS06265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynPROSU1_RS06300	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynPROSU1_RS06305	COG0515	serine threonine protein kinase
SynPROSU1_RS06330	COG2226	methyltransferase
SynPROSU1_RS06335	COG0174	glutamine synthetase
SynPROSU1_RS06345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynPROSU1_RS06365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynPROSU1_RS06385	COG0612	Peptidase, M16
SynPROSU1_RS06415	COG1216	Glycosyl transferase, family 2
SynPROSU1_RS06420	COG0052	Belongs to the universal ribosomal protein uS2 family
SynPROSU1_RS06425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynPROSU1_RS06435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynPROSU1_RS06440	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynPROSU1_RS06445	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynPROSU1_RS06450	COG0751	glycine-tRNA ligase activity
SynPROSU1_RS06460	COG0644	oxidoreductase
SynPROSU1_RS06470	COG0826	peptidase U32
SynPROSU1_RS06475	COG1217	gtp-binding protein TYPA
SynPROSU1_RS06500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynPROSU1_RS06525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynPROSU1_RS06530	COG1494	fructose-1,6-bisphosphatase
SynPROSU1_RS06535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynPROSU1_RS06540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROSU1_RS06545	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynPROSU1_RS06550	COG0363	glucosamine-6-phosphate deaminase activity
SynPROSU1_RS06565	COG0129	dihydroxy-acid dehydratase activity
SynPROSU1_RS06575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynPROSU1_RS06580	COG1357	PFAM Pentapeptide repeats (8 copies)
SynPROSU1_RS06615	COG0300	oxidoreductase activity
SynPROSU1_RS06660	COG4106	trans-aconitate 2-methyltransferase activity
SynPROSU1_RS06665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynPROSU1_RS06680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynPROSU1_RS06685	COG1122	ATPase activity
SynPROSU1_RS06705	COG1836	PFAM Integral membrane protein DUF92
SynPROSU1_RS06730	COG3639	organic phosphonate transmembrane transporter activity
SynPROSU1_RS06735	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynPROSU1_RS06740	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynPROSU1_RS06745	COG0436	Aminotransferase
SynPROSU1_RS06755	COG1573	uracil-dna glycosylase
SynPROSU1_RS06760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynPROSU1_RS06765	COG0793	Belongs to the peptidase S41A family
SynPROSU1_RS06775	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynPROSU1_RS06830	COG0861	Integral membrane protein TerC family
SynPROSU1_RS06845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynPROSU1_RS06855	COG0312	modulator of DNA gyrase
SynPROSU1_RS06860	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynPROSU1_RS06875	COG0163	prenyltransferase activity
SynPROSU1_RS06880	COG0557	exoribonuclease II activity
SynPROSU1_RS06890	COG2119	membrane
SynPROSU1_RS06905	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynPROSU1_RS06905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynPROSU1_RS06910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynPROSU1_RS06925	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynPROSU1_RS06930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROSU1_RS06935	COG1615	UPF0182 protein
SynPROSU1_RS06940	COG0450	alkyl hydroperoxide reductase
SynPROSU1_RS06955	COG0739	heme binding
SynPROSU1_RS06960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynPROSU1_RS06965	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SynPROSU1_RS06995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynPROSU1_RS07000	COG1233	COG1233 Phytoene dehydrogenase and related
SynPROSU1_RS07005	COG0557	exoribonuclease II activity
SynPROSU1_RS07010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynPROSU1_RS07015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynPROSU1_RS07020	COG0072	phenylalanine-tRNA ligase activity
SynPROSU1_RS07025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynPROSU1_RS07070	COG2385	sporulation resulting in formation of a cellular spore
SynPROSU1_RS07095	COG1410	methionine synthase
SynPROSU1_RS07095	COG0646	methionine synthase
SynPROSU1_RS07100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynPROSU1_RS07115	COG0613	PHP domain protein
SynPROSU1_RS07115	COG0613	PHP domain protein
SynPROSU1_RS07120	COG1981	membrane
SynPROSU1_RS07125	COG3046	protein related to deoxyribodipyrimidine photolyase
SynPROSU1_RS07135	COG0322	excinuclease ABC activity
SynPROSU1_RS07145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynPROSU1_RS07155	COG2027	D-alanyl-D-alanine carboxypeptidase
SynPROSU1_RS07170	COG1104	cysteine desulfurase activity
SynPROSU1_RS07175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynPROSU1_RS07185	COG0495	leucyl-tRNA aminoacylation
SynPROSU1_RS07195	COG0166	Belongs to the GPI family
SynPROSU1_RS07225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynPROSU1_RS07230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynPROSU1_RS07235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynPROSU1_RS07235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynPROSU1_RS07240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROSU1_RS07245	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynPROSU1_RS07250	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynPROSU1_RS07260	COG0484	heat shock protein binding
SynPROSU1_RS07265	COG0443	Heat shock 70 kDa protein
SynPROSU1_RS07270	COG0573	inorganic phosphate transmembrane transporter activity
SynPROSU1_RS07275	COG0581	inorganic phosphate transmembrane transporter activity
SynPROSU1_RS07280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynPROSU1_RS07295	COG0483	inositol monophosphate 1-phosphatase activity
SynPROSU1_RS07300	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynPROSU1_RS07310	COG0326	Molecular chaperone. Has ATPase activity
SynPROSU1_RS07315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynPROSU1_RS07320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROSU1_RS07325	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynPROSU1_RS07330	COG1653	transport
SynPROSU1_RS07335	COG1175	transmembrane transport
SynPROSU1_RS07375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynPROSU1_RS07380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynPROSU1_RS07390	COG0762	integral membrane protein
SynPROSU1_RS07405	COG0469	pyruvate kinase activity
SynPROSU1_RS07410	COG0577	efflux transmembrane transporter activity
SynPROSU1_RS07410	COG1136	(ABC) transporter
SynPROSU1_RS07415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROSU1_RS07425	COG0740	serine-type endopeptidase activity
SynPROSU1_RS07455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynPROSU1_RS07490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynPROSU1_RS07495	COG1175	transmembrane transport
SynPROSU1_RS07500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynPROSU1_RS07530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SynPROSU1_RS07575	COG1793	dna ligase
SynPROSU1_RS07585	COG1201	RNA secondary structure unwinding
SynPROSU1_RS07660	COG2226	methyltransferase
SynPROSU1_RS07695	COG1119	ATPase activity
SynPROSU1_RS07725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynPROSU1_RS07750	COG1121	(ABC) transporter
SynPROSU1_RS07755	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynPROSU1_RS07760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynPROSU1_RS07765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynPROSU1_RS07785	COG0572	uridine kinase
SynPROSU1_RS07845	COG2032	superoxide dismutase activity
SynPROSU1_RS07860	COG0724	RNA recognition motif
SynPROSU1_RS07870	COG0463	Glycosyl transferase, family 2
SynPROSU1_RS07975	COG2124	cytochrome p450
SynPROSU1_RS08075	COG0405	Gamma-glutamyltransferase
SynPROSU1_RS08190	COG3659	wide pore channel activity
SynPROSU1_RS08200	COG3128	pkhd-type hydroxylase
SynPROSU1_RS08205	COG1840	ABC-type Fe3 transport system, periplasmic component
SynPROSU1_RS08230	COG0492	ferredoxin-NADP+ reductase activity
SynPROSU1_RS08235	COG0716	FMN binding
SynPROSU1_RS08245	COG3659	wide pore channel activity
SynPROSU1_RS08255	COG2010	Cytochrome c
SynPROSU1_RS08300	COG2207	Transcriptional regulator
SynPROSU1_RS08315	COG0701	Predicted permease
SynPROSU1_RS08340	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynPROSU1_RS08345	COG1121	(ABC) transporter
SynPROSU1_RS08350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynPROSU1_RS08380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynPROSU1_RS08400	COG1640	4-alpha-glucanotransferase
SynPROSU1_RS08410	COG1187	pseudouridine synthase activity
SynPROSU1_RS08415	COG5002	protein histidine kinase activity
SynPROSU1_RS08420	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_RS08440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROSU1_RS08445	COG1982	Orn Lys Arg decarboxylase major
SynPROSU1_RS08450	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynPROSU1_RS08455	COG0575	Belongs to the CDS family
SynPROSU1_RS08465	COG2267	carboxylic ester hydrolase activity
SynPROSU1_RS08470	COG0371	Dehydrogenase
SynPROSU1_RS08475	COG0542	response to heat
SynPROSU1_RS08485	COG0019	diaminopimelate decarboxylase activity
SynPROSU1_RS08490	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynPROSU1_RS08495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynPROSU1_RS08500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynPROSU1_RS08510	COG1054	Belongs to the UPF0176 family
SynPROSU1_RS08530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynPROSU1_RS08535	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynPROSU1_RS08610	COG0589	response to stress
SynPROSU1_RS08610	COG0475	glutathione-regulated potassium exporter activity
SynPROSU1_RS08615	COG1132	(ABC) transporter
SynPROSU1_RS08640	COG0513	Belongs to the DEAD box helicase family
SynPROSU1_RS08650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynPROSU1_RS08665	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynPROSU1_RS08685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynPROSU1_RS08700	COG0271	Belongs to the BolA IbaG family
SynPROSU1_RS08705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynPROSU1_RS08715	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_RS08765	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynPROSU1_RS08775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynPROSU1_RS09125	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynPROSU1_RS09165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynPROSU1_RS09180	COG0735	belongs to the Fur family
SynPROSU1_RS09225	COG0625	glutathione transferase activity
SynPROSU1_RS09265	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynPROSU1_RS09300	COG1126	abc transporter atp-binding protein
SynPROSU1_RS09305	COG0765	amino acid transport
SynPROSU1_RS09310	COG4597	amino acid ABC transporter
SynPROSU1_RS09315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynPROSU1_RS09325	COG0659	secondary active sulfate transmembrane transporter activity
SynPROSU1_RS09365	COG0799	negative regulation of ribosome biogenesis
SynPROSU1_RS09375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynPROSU1_RS09385	COG1115	amino acid carrier protein
SynPROSU1_RS09395	COG1132	(ABC) transporter
SynPROSU1_RS09405	COG0149	triose-phosphate isomerase activity
SynPROSU1_RS09410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynPROSU1_RS09425	COG1429	ligase activity, forming nitrogen-metal bonds
SynPROSU1_RS09430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynPROSU1_RS09440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROSU1_RS09445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynPROSU1_RS09455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynPROSU1_RS09485	COG2205	protein histidine kinase activity
SynPROSU1_RS09490	COG2326	polyphosphate kinase activity
SynPROSU1_RS09525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynPROSU1_RS09530	COG0640	Transcriptional regulator
SynPROSU1_RS09540	COG0668	transmembrane transport
SynPROSU1_RS09555	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynPROSU1_RS09560	COG0047	phosphoribosylformylglycinamidine synthase activity
SynPROSU1_RS09565	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynPROSU1_RS09575	COG0191	fructose-bisphosphate aldolase activity
SynPROSU1_RS09580	COG3588	fructose-bisphosphate aldolase
SynPROSU1_RS09585	COG0673	inositol 2-dehydrogenase activity
SynPROSU1_RS09595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynPROSU1_RS09605	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynPROSU1_RS09615	COG3954	Phosphoribulokinase
SynPROSU1_RS09620	COG0473	3-isopropylmalate dehydrogenase activity
SynPROSU1_RS09625	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynPROSU1_RS09630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynPROSU1_RS09645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynPROSU1_RS09660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynPROSU1_RS09665	COG2197	response regulator
SynPROSU1_RS09675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynPROSU1_RS09700	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROSU1_RS09750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROSU1_RS09760	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynPROSU1_RS09865	COG0308	aminopeptidase N
SynPROSU1_RS09880	COG2205	protein histidine kinase activity
SynPROSU1_RS09900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynPROSU1_RS09910	COG1797	cobyrinic acid a,c-diamide synthase activity
SynPROSU1_RS09915	COG1254	Belongs to the acylphosphatase family
SynPROSU1_RS09930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynPROSU1_RS09950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynPROSU1_RS09955	COG1480	7TM receptor with intracellular HD hydrolase
SynPROSU1_RS09965	COG0564	pseudouridine synthase activity
SynPROSU1_RS09975	COG0011	TIGRFAM Protein of
SynPROSU1_RS10005	COG0395	ABC-type sugar transport system, permease component
SynPROSU1_RS10010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynPROSU1_RS10015	COG1543	Belongs to the glycosyl hydrolase 57 family
SynPROSU1_RS10020	COG0644	oxidoreductase
SynPROSU1_RS10025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynPROSU1_RS10030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynPROSU1_RS10035	COG0516	GMP reductase activity
SynPROSU1_RS10040	COG3118	belongs to the thioredoxin family
SynPROSU1_RS10045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynPROSU1_RS10055	COG2010	Cytochrome c
SynPROSU1_RS10060	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynPROSU1_RS10075	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROSU1_RS10080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynPROSU1_RS10085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynPROSU1_RS10095	COG2166	iron-sulfur cluster assembly
SynPROSU1_RS10100	COG0460	homoserine dehydrogenase
SynPROSU1_RS10110	COG0747	negative chemotaxis
SynPROSU1_RS10115	COG0601	transmembrane transport
SynPROSU1_RS10140	COG0012	GTP binding
SynPROSU1_RS10150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynPROSU1_RS10150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynPROSU1_RS10160	COG0215	cysteine-tRNA ligase activity
SynPROSU1_RS10175	COG0733	neurotransmitter:sodium symporter activity
SynPROSU1_RS10180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynPROSU1_RS10230	COG0492	ferredoxin-NADP+ reductase activity
SynPROSU1_RS10235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynPROSU1_RS10245	COG2226	methyltransferase
SynPROSU1_RS10270	COG2267	carboxylic ester hydrolase activity
SynPROSU1_RS10275	COG0440	acetolactate synthase activity
SynPROSU1_RS10280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROSU1_RS10310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynPROSU1_RS10320	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynPROSU1_RS10325	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynPROSU1_RS10335	COG1022	Amp-dependent synthetase and ligase
SynPROSU1_RS10340	COG0321	lipoyl(octanoyl) transferase activity
SynPROSU1_RS10345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynPROSU1_RS10350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynPROSU1_RS10355	COG1381	Involved in DNA repair and RecF pathway recombination
SynPROSU1_RS10365	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_RS10390	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynPROSU1_RS10400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynPROSU1_RS10405	COG1799	cell septum assembly
SynPROSU1_RS10410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynPROSU1_RS10420	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynPROSU1_RS10425	COG1160	GTP binding
SynPROSU1_RS10435	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROSU1_RS10445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynPROSU1_RS10450	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_RS10450	COG1216	Glycosyl transferase, family 2
SynPROSU1_RS10470	COG1088	dTDP-glucose 4,6-dehydratase activity
SynPROSU1_RS10500	COG0114	fumarate hydratase activity
SynPROSU1_RS10505	COG4581	dead DEAH box helicase
SynPROSU1_RS10520	COG0385	Bile acid
SynPROSU1_RS10525	COG0156	8-amino-7-oxononanoate synthase activity
SynPROSU1_RS10540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynPROSU1_RS10555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynPROSU1_RS10570	COG0357	Ribosomal RNA small subunit methyltransferase G
SynPROSU1_RS10605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynPROSU1_RS10610	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROSU1_RS10615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynPROSU1_RS10620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynPROSU1_RS10625	COG0085	RNA polymerase activity
SynPROSU1_RS10630	COG0084	hydrolase, TatD family'
SynPROSU1_RS10635	COG0268	Binds directly to 16S ribosomal RNA
SynPROSU1_RS10640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynPROSU1_RS10645	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynPROSU1_RS10650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROSU1_RS10665	COG0641	radical SAM
SynPROSU1_RS10675	COG2132	Multicopper oxidase
SynPROSU1_RS10705	COG5002	protein histidine kinase activity
SynPROSU1_RS10725	COG0779	Required for maturation of 30S ribosomal subunits
SynPROSU1_RS10730	COG0195	Participates in both transcription termination and antitermination
SynPROSU1_RS10740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynPROSU1_RS10765	COG3781	membrane
SynPROSU1_RS10775	COG1053	succinate dehydrogenase
SynPROSU1_RS10800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynPROSU1_RS10805	COG0776	regulation of translation
SynPROSU1_RS10830	COG2211	Major facilitator Superfamily
SynPROSU1_RS10835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynPROSU1_RS10850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynPROSU1_RS10870	COG0284	orotidine-5'-phosphate decarboxylase activity
SynPROSU1_RS10890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynPROSU1_RS10940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynPROSU1_RS10955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROSU1_RS10960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynPROSU1_RS10965	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynPROSU1_RS10970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynPROSU1_RS10975	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynPROSU1_RS10985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynPROSU1_RS10995	COG0151	Belongs to the GarS family
SynPROSU1_RS11000	COG5002	protein histidine kinase activity
SynPROSU1_RS11005	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynPROSU1_RS11010	COG4251	negative regulation of phosphorylation
SynPROSU1_RS11020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynPROSU1_RS11025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynPROSU1_RS11030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROSU1_RS11035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynPROSU1_RS11040	COG0217	transcriptional regulatory protein
SynPROSU1_RS11050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynPROSU1_RS11075	COG0363	glucosamine-6-phosphate deaminase activity
SynPROSU1_RS11080	COG2385	sporulation resulting in formation of a cellular spore
SynPROSU1_RS11080	COG2247	cell wall binding repeat
SynPROSU1_RS11085	COG1234	tRNA 3'-trailer cleavage
SynPROSU1_RS11090	COG2010	Cytochrome c
SynPROSU1_RS11105	COG2264	protein methyltransferase activity
SynPROSU1_RS11110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynPROSU1_RS11130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynPROSU1_RS11165	COG0443	Heat shock 70 kDa protein
SynPROSU1_RS11180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynPROSU1_RS11185	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynPROSU1_RS11225	COG0459	protein refolding
SynPROSU1_RS11230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynPROSU1_RS11235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynPROSU1_RS11240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynPROSU1_RS11255	COG0387	Pfam Sodium calcium exchanger
SynPROSU1_RS11260	COG0006	proline dipeptidase activity
SynPROSU1_RS11265	COG0457	Tetratricopeptide repeat
SynPROSU1_RS11270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynPROSU1_RS11275	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynPROSU1_RS11280	COG1253	flavin adenine dinucleotide binding
SynPROSU1_RS11285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynPROSU1_RS11290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynPROSU1_RS11295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynPROSU1_RS11295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynPROSU1_RS11300	COG0686	Belongs to the AlaDH PNT family
SynPROSU1_RS11305	COG3012	SEC-C Motif Domain Protein
SynPROSU1_RS11310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynPROSU1_RS11320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynPROSU1_RS11345	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynPROSU1_RS11350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynPROSU1_RS11355	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynPROSU1_RS11360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynPROSU1_RS11365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynPROSU1_RS11370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynPROSU1_RS11375	COG0356	it plays a direct role in the translocation of protons across the membrane
SynPROSU1_RS11385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROSU1_RS11390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROSU1_RS11410	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SynPROSU1_RS11420	COG0772	Belongs to the SEDS family
SynPROSU1_RS11430	COG1333	cytochrome c biogenesis protein
SynPROSU1_RS11435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynPROSU1_RS11450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynPROSU1_RS11465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynPROSU1_RS11475	COG3562	capsule polysaccharide
SynPROSU1_RS11485	COG1083	cytidylyl-transferase
SynPROSU1_RS11505	COG2089	acid synthase
SynPROSU1_RS11565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROSU1_RS11605	COG0116	Belongs to the methyltransferase superfamily
SynPROSU1_RS11640	COG1196	nuclear chromosome segregation
SynPROSU1_RS11650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROSU1_RS11665	COG0439	Biotin carboxylase
SynPROSU1_RS11680	COG0515	serine threonine protein kinase
SynPROSU1_RS11695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROSU1_RS11700	COG4178	(ABC) transporter
SynPROSU1_RS11705	COG0537	adenosine 5'-monophosphoramidase activity
SynPROSU1_RS11710	COG0606	chelatase, subunit chli
SynPROSU1_RS11730	COG0242	peptide deformylase activity
SynPROSU1_RS11750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynPROSU1_RS11755	COG0719	Fe-S assembly protein
SynPROSU1_RS11760	COG0396	ATPase activity
SynPROSU1_RS11765	COG0719	Fe-S assembly protein
SynPROSU1_RS11770	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynPROSU1_RS11790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROSU1_RS11815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROSU1_RS11835	COG0033	Phosphoglucomutase
SynPROSU1_RS11845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynPROSU1_RS11850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynPROSU1_RS11855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynPROSU1_RS11870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROSU1_RS11875	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynPROSU1_RS11880	COG0175	sulfate reduction
SynPROSU1_RS11885	COG1252	NADH dehydrogenase
SynPROSU1_RS11890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynPROSU1_RS11895	COG3273	potassium ion transport
SynPROSU1_RS11895	COG0471	metal ion transport
SynPROSU1_RS11900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynPROSU1_RS11905	COG0569	domain protein
SynPROSU1_RS11910	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynPROSU1_RS11935	COG0488	(ABC) transporter
SynPROSU1_RS11945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROSU1_RS11960	COG1643	Atp-dependent helicase
SynPROSU1_RS11975	COG1570	exodeoxyribonuclease VII activity
SynPROSU1_RS12025	COG0483	inositol monophosphate 1-phosphatase activity
SynPROSU1_RS12040	COG1968	undecaprenyl-diphosphatase activity
SynPROSU1_RS12050	COG1555	photosystem II stabilization
SynPROSU1_RS12055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynPROSU1_RS12060	COG4243	Vitamin k epoxide reductase
SynPROSU1_RS12065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROSU1_RS12080	COG1032	radical SAM domain protein
SynPROSU1_RS12110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynPROSU1_RS12135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynPROSU1_RS12145	COG0463	Glycosyl transferase, family 2
SynPROSU1_RS12145	COG0457	Tetratricopeptide repeat
SynPROSU1_RS12150	COG1587	Uroporphyrinogen-III synthase
SynPROSU1_RS12165	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynPROSU1_RS12170	COG0316	Belongs to the HesB IscA family
SynPROSU1_RS12195	COG1090	epimerase
SynPROSU1_RS12210	COG0484	heat shock protein binding
SynPROSU1_RS12215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynPROSU1_RS12220	COG3659	wide pore channel activity
SynPROSU1_RS12225	COG3659	wide pore channel activity
SynPROSU1_RS12235	COG1215	transferase activity, transferring glycosyl groups
SynPROSU1_RS12275	COG1122	ATPase activity
SynPROSU1_RS12285	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_RS12295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynPROSU1_RS12300	COG2217	Heavy metal translocating P-type atpase
SynPROSU1_RS12305	COG3063	Type IV pilus biogenesis stability protein PilW
SynPROSU1_RS12310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynPROSU1_RS12320	COG0416	fatty acid biosynthetic process
SynPROSU1_RS12325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynPROSU1_RS12330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynPROSU1_RS12335	COG0204	Acyl-transferase
SynPROSU1_RS12335	COG0318	PFAM AMP-dependent synthetase and ligase
SynPROSU1_RS12345	COG1214	PFAM Peptidase M22, glycoprotease
SynPROSU1_RS12355	COG0617	tRNA 3'-terminal CCA addition
SynPROSU1_RS12360	COG0724	RNA recognition motif
SynPROSU1_RS12365	COG1562	ergosterol biosynthetic process
SynPROSU1_RS12370	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynPROSU1_RS12370	COG0493	'glutamate synthase
SynPROSU1_RS12385	COG0583	DNA-binding transcription factor activity
SynPROSU1_RS12395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynPROSU1_RS12400	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_RS12415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynPROSU1_RS12425	COG2197	response regulator
SynPROSU1_RS12430	COG2954	triphosphatase activity
SynPROSU1_RS12435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynPROSU1_RS12440	COG0713	ATP synthesis coupled electron transport
SynPROSU1_RS12450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_RS12455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynPROSU1_RS12460	COG0372	Belongs to the citrate synthase family
SynPROSU1_RS12465	COG2062	phosphohistidine phosphatase, SixA
SynPROSU1_RS12480	COG1420	regulation of RNA biosynthetic process
SynPROSU1_RS12485	COG0133	tryptophan synthase activity
SynPROSU1_RS12495	COG0023	Translation Initiation Factor
SynPROSU1_RS12500	COG0529	Catalyzes the synthesis of activated sulfate
SynPROSU1_RS12505	COG0628	permease
SynPROSU1_RS12515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynPROSU1_RS12525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROSU1_RS12530	COG0564	pseudouridine synthase activity
SynPROSU1_RS12535	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_RS12545	COG1104	cysteine desulfurase activity
SynPROSU1_RS12555	COG0275	rRNA processing
SynPROSU1_RS12560	COG0649	NAD binding
SynPROSU1_RS12575	COG0824	Thioesterase
SynPROSU1_RS12590	COG1575	Belongs to the MenA family. Type 1 subfamily
SynPROSU1_RS12600	COG0189	ligase activity
SynPROSU1_RS12605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynPROSU1_RS12620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynPROSU1_RS12625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynPROSU1_RS12640	COG0252	asparaginase activity
SynPROSU1_RS12645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynPROSU1_RS12650	COG0018	arginyl-trna synthetase
SynPROSU1_RS12655	COG0157	Belongs to the NadC ModD family
SynPROSU1_RS12660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynPROSU1_RS12670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynPROSU1_RS12675	COG4172	Belongs to the ABC transporter superfamily
SynPROSU1_RS12685	COG0564	pseudouridine synthase activity
SynPROSU1_RS12690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynPROSU1_RS12695	COG0126	phosphoglycerate kinase activity
SynPROSU1_RS12715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynPROSU1_RS12720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynPROSU1_RS12755	COG0167	dihydroorotate dehydrogenase activity
SynPROSU1_RS12760	COG0328	RNA-DNA hybrid ribonuclease activity
SynPROSU1_RS12770	COG0222	ribosome binding
SynPROSU1_RS12775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynPROSU1_RS12780	COG0081	regulation of translation
SynPROSU1_RS12785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynPROSU1_RS12790	COG0250	Participates in transcription elongation, termination and antitermination
SynPROSU1_RS12795	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynPROSU1_RS12800	COG0542	response to heat
SynPROSU1_RS12805	COG0346	lactoylglutathione lyase activity
SynPROSU1_RS12810	COG0148	phosphopyruvate hydratase activity
SynPROSU1_RS12815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROSU1_RS12835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynPROSU1_RS12840	COG0237	dephospho-CoA kinase activity
SynPROSU1_RS12855	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynPROSU1_RS12865	COG2022	thiamine diphosphate biosynthetic process
SynPROSU1_RS12865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynPROSU1_RS12885	COG0105	UTP biosynthetic process
SynPROSU1_RS12890	COG1166	arginine decarboxylase activity
SynPROSU1_RS12925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynPROSU1_RS12935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynPROSU1_RS12970	COG0426	domain, Protein
SynPROSU1_RS12970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROSU1_RS13000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROSU1_RS13000	COG0426	domain, Protein
SynPROSU1_RS13005	COG1773	rubredoxin
SynPROSU1_RS13005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROSU1_RS13010	COG1733	regulation of RNA biosynthetic process
SynPROSU1_RS13020	COG1741	Belongs to the pirin family
SynPROSU1_RS13035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynPROSU1_RS13035	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynPROSU1_RS13040	COG0509	glycine decarboxylation via glycine cleavage system
SynPROSU1_RS13045	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynPROSU1_RS13055	COG2133	pyrroloquinoline quinone binding
SynPROSU1_RS13055	COG5183	chlorophyll binding
SynPROSU1_RS13060	COG0359	binds to the 23S rRNA
SynPROSU1_RS13065	COG0305	Participates in initiation and elongation during chromosome replication
SynPROSU1_RS13065	COG1372	Participates in initiation and elongation during chromosome replication
SynPROSU1_RS13065	COG0305	Participates in initiation and elongation during chromosome replication
SynPROSU1_RS13065	COG1372	Participates in initiation and elongation during chromosome replication
SynPROSU1_RS13080	COG0445	tRNA wobble uridine modification
SynPROSU1_RS13115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynPROSU1_RS13125	COG0398	Pfam SNARE associated Golgi protein
SynPROSU1_RS13140	COG1131	(ABC) transporter
SynPROSU1_RS13160	COG0525	valine-tRNA ligase activity
SynPROSU1_RS13170	COG3264	Mechanosensitive ion channel
SynPROSU1_RS13170	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynPROSU1_RS13200	COG4221	oxidoreductase activity
SynPROSU1_RS13265	COG3956	TIGRFAM MazG family protein
SynPROSU1_RS13275	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynPROSU1_RS13280	COG0010	Belongs to the arginase family
SynPROSU1_RS13295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynPROSU1_RS13300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynPROSU1_RS13305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_RS13310	COG0783	Belongs to the Dps family
SynPROSU1_RS13315	COG0504	CTP synthase activity
SynPROSU1_RS13320	COG0602	queuosine metabolic process
SynPROSU1_RS13335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynPROSU1_RS13355	COG0366	Alpha amylase catalytic
SynPROSU1_RS13360	COG0463	Glycosyl transferase, family 2
SynPROSU1_RS13385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynPROSU1_RS13425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynPROSU1_RS13430	COG0830	nickel cation binding
SynPROSU1_RS13435	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynPROSU1_RS13440	COG0829	nickel cation binding
SynPROSU1_RS13445	COG0831	urea catabolic process
SynPROSU1_RS13450	COG0832	Belongs to the urease beta subunit family
SynPROSU1_RS13455	COG0804	urea catabolic process
SynPROSU1_RS13485	COG0367	asparagine synthase
SynPROSU1_RS13500	COG2308	Evidence 4 Homologs of previously reported genes of
SynPROSU1_RS13520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynPROSU1_RS13525	COG0746	molybdenum cofactor guanylyltransferase activity
SynPROSU1_RS13530	COG2223	nitrite transmembrane transporter activity
SynPROSU1_RS13535	COG0243	molybdopterin cofactor binding
SynPROSU1_RS13555	COG0315	cyclic pyranopterin monophosphate synthase activity
SynPROSU1_RS13570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynPROSU1_RS13575	COG0314	molybdopterin synthase activity
SynPROSU1_RS13585	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynPROSU1_RS13590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynPROSU1_RS13605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynPROSU1_RS13615	COG2116	formate transmembrane transporter activity
SynPROSU1_RS13625	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynPROSU1_RS13635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynPROSU1_RS13650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynPROSU1_RS13655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_RS13660	COG0170	dolichyl monophosphate biosynthetic process
SynPROSU1_RS13665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynPROSU1_RS13670	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynPROSU1_RS13680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROSU1_RS13690	COG0788	formyltetrahydrofolate deformylase activity
SynPROSU1_RS13705	COG0443	Heat shock 70 kDa protein
SynPROSU1_RS13710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynPROSU1_RS13720	COG0360	Binds together with S18 to 16S ribosomal RNA
SynPROSU1_RS13730	COG0137	argininosuccinate synthase activity
SynPROSU1_RS13745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynPROSU1_RS13765	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynPROSU1_RS13775	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_RS13785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynPROSU1_RS13790	COG0497	DNA recombination
SynPROSU1_RS13795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROSU1_RS13805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine