locus-tag	class	description
SynRS9902_RS00005	COG0592	DNA-directed DNA polymerase activity
SynRS9902_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynRS9902_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynRS9902_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynRS9902_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynRS9902_RS00055	COG0552	protein localization to endoplasmic reticulum
SynRS9902_RS00060	COG2208	phosphoserine phosphatase activity
SynRS9902_RS00065	COG0165	Argininosuccinate lyase
SynRS9902_RS00070	COG0724	RNA recognition motif
SynRS9902_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynRS9902_RS00085	COG2081	HI0933 family
SynRS9902_RS00095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynRS9902_RS00100	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynRS9902_RS00105	COG0484	heat shock protein binding
SynRS9902_RS00115	COG1162	GTPase activity
SynRS9902_RS00120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynRS9902_RS00125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynRS9902_RS00130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynRS9902_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynRS9902_RS00145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynRS9902_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynRS9902_RS00155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynRS9902_RS00160	COG0511	ligase activity, forming carbon-carbon bonds
SynRS9902_RS00165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynRS9902_RS00230	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynRS9902_RS00235	COG0519	Catalyzes the synthesis of GMP from XMP
SynRS9902_RS00235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynRS9902_RS00255	COG0768	penicillin binding
SynRS9902_RS00260	COG0438	transferase activity, transferring glycosyl groups
SynRS9902_RS00265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynRS9902_RS00275	COG2022	thiamine diphosphate biosynthetic process
SynRS9902_RS00290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynRS9902_RS00295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynRS9902_RS00300	COG2385	sporulation resulting in formation of a cellular spore
SynRS9902_RS00305	COG1215	transferase activity, transferring glycosyl groups
SynRS9902_RS00315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynRS9902_RS00325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynRS9902_RS00330	COG0740	serine-type endopeptidase activity
SynRS9902_RS00335	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynRS9902_RS00340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynRS9902_RS00345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynRS9902_RS00350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynRS9902_RS00375	COG0037	tRNA processing
SynRS9902_RS00390	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynRS9902_RS00395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynRS9902_RS00405	COG0556	nucleotide-excision repair
SynRS9902_RS00415	COG0653	protein targeting
SynRS9902_RS00425	COG1045	serine acetyltransferase
SynRS9902_RS00430	COG1725	Transcriptional regulator
SynRS9902_RS00435	COG0412	Dienelactone hydrolase
SynRS9902_RS00440	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynRS9902_RS00445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynRS9902_RS00450	COG0187	DNA topoisomerase II activity
SynRS9902_RS00450	COG1372	Participates in initiation and elongation during chromosome replication
SynRS9902_RS00460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynRS9902_RS00465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynRS9902_RS00470	COG0386	Belongs to the glutathione peroxidase family
SynRS9902_RS00475	COG2239	Acts as a magnesium transporter
SynRS9902_RS00480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9902_RS00485	COG0596	Alpha beta hydrolase
SynRS9902_RS00490	COG1194	a g-specific adenine glycosylase
SynRS9902_RS00500	COG0802	atpase or kinase
SynRS9902_RS00505	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynRS9902_RS00510	COG0586	Pfam SNARE associated Golgi protein
SynRS9902_RS00515	COG0629	single-stranded DNA binding
SynRS9902_RS00525	COG1792	Involved in formation and maintenance of cell shape
SynRS9902_RS00545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynRS9902_RS00570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynRS9902_RS00575	COG2255	four-way junction helicase activity
SynRS9902_RS00585	COG1473	amidohydrolase
SynRS9902_RS00600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynRS9902_RS00615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynRS9902_RS00620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynRS9902_RS00625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynRS9902_RS00630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9902_RS00635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynRS9902_RS00645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynRS9902_RS00655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynRS9902_RS00660	COG0571	ribonuclease III activity
SynRS9902_RS00685	COG0058	SHG alpha-glucan phosphorylase activity
SynRS9902_RS00690	COG0475	glutathione-regulated potassium exporter activity
SynRS9902_RS00710	COG0277	FAD linked oxidase domain protein
SynRS9902_RS00720	COG0247	lactate metabolic process
SynRS9902_RS00730	COG0538	isocitrate dehydrogenase activity
SynRS9902_RS00735	COG0463	Glycosyl transferase, family 2
SynRS9902_RS00745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SynRS9902_RS00755	COG5398	heme oxygenase
SynRS9902_RS00765	COG1132	(ABC) transporter
SynRS9902_RS00770	COG0438	transferase activity, transferring glycosyl groups
SynRS9902_RS00780	COG0438	transferase activity, transferring glycosyl groups
SynRS9902_RS00785	COG0438	transferase activity, transferring glycosyl groups
SynRS9902_RS00790	COG0438	transferase activity, transferring glycosyl groups
SynRS9902_RS00805	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynRS9902_RS00825	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynRS9902_RS00830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynRS9902_RS00835	COG0517	IMP dehydrogenase activity
SynRS9902_RS00835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynRS9902_RS00840	COG0617	tRNA 3'-terminal CCA addition
SynRS9902_RS00850	COG0709	Synthesizes selenophosphate from selenide and ATP
SynRS9902_RS00855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynRS9902_RS00865	COG2274	protein secretion by the type I secretion system
SynRS9902_RS00875	COG0438	transferase activity, transferring glycosyl groups
SynRS9902_RS00880	COG0124	histidyl-tRNA synthetase
SynRS9902_RS00890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynRS9902_RS00920	COG4447	cellulose binding
SynRS9902_RS00925	COG1773	rubredoxin
SynRS9902_RS00930	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9902_RS00935	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9902_RS00940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9902_RS00945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynRS9902_RS00950	COG3842	ATPase activity
SynRS9902_RS00960	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynRS9902_RS00960	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynRS9902_RS00970	COG4988	ABC transporter
SynRS9902_RS00975	COG0494	nUDIX hydrolase
SynRS9902_RS00980	COG0415	Belongs to the DNA photolyase family
SynRS9902_RS01025	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynRS9902_RS01030	COG0131	Imidazoleglycerol-phosphate dehydratase
SynRS9902_RS01035	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynRS9902_RS01040	COG2994	toxin metabolic process
SynRS9902_RS01060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynRS9902_RS01080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynRS9902_RS01085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynRS9902_RS01095	COG0354	folic acid binding
SynRS9902_RS01100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynRS9902_RS01115	COG1253	flavin adenine dinucleotide binding
SynRS9902_RS01120	COG0673	inositol 2-dehydrogenase activity
SynRS9902_RS01130	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SynRS9902_RS01140	COG0343	queuine tRNA-ribosyltransferase activity
SynRS9902_RS01145	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynRS9902_RS01165	COG0138	bifunctional purine biosynthesis protein purh
SynRS9902_RS01180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynRS9902_RS01185	COG0004	ammonium transporteR
SynRS9902_RS01190	COG1489	DNA binding
SynRS9902_RS01195	COG0728	peptidoglycan biosynthetic process
SynRS9902_RS01220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynRS9902_RS01225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynRS9902_RS01230	COG1546	Belongs to the CinA family
SynRS9902_RS01230	COG1058	Belongs to the CinA family
SynRS9902_RS01235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynRS9902_RS01240	COG0066	3-isopropylmalate dehydratase activity
SynRS9902_RS01275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynRS9902_RS01280	COG0193	aminoacyl-tRNA hydrolase activity
SynRS9902_RS01295	COG4372	Transposase
SynRS9902_RS01300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynRS9902_RS01305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynRS9902_RS01315	COG0717	Belongs to the dCTP deaminase family
SynRS9902_RS01325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynRS9902_RS01330	COG0741	lytic transglycosylase activity
SynRS9902_RS01335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynRS9902_RS01350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynRS9902_RS01370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynRS9902_RS01390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynRS9902_RS01395	COG1402	creatininase
SynRS9902_RS01405	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynRS9902_RS01410	COG2094	Belongs to the DNA glycosylase MPG family
SynRS9902_RS01415	COG0540	Belongs to the ATCase OTCase family
SynRS9902_RS01445	COG3536	Protein conserved in bacteria
SynRS9902_RS01450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynRS9902_RS01465	COG2046	Belongs to the sulfate adenylyltransferase family
SynRS9902_RS01465	COG0529	Catalyzes the synthesis of activated sulfate
SynRS9902_RS01470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynRS9902_RS01485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynRS9902_RS01500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynRS9902_RS01510	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynRS9902_RS01515	COG0436	Aminotransferase
SynRS9902_RS01525	COG1530	ribonuclease E activity
SynRS9902_RS01530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynRS9902_RS01545	COG2226	methyltransferase
SynRS9902_RS01550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynRS9902_RS01555	COG0051	transcription antitermination factor activity, RNA binding
SynRS9902_RS01560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynRS9902_RS01565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynRS9902_RS01570	COG0049	tRNA binding
SynRS9902_RS01575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynRS9902_RS01580	COG0316	Belongs to the HesB IscA family
SynRS9902_RS01590	COG0067	glutamate synthase
SynRS9902_RS01590	COG0069	glutamate synthase activity
SynRS9902_RS01590	COG0070	glutamate synthase
SynRS9902_RS01600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynRS9902_RS01620	COG2885	chlorophyll binding
SynRS9902_RS01625	COG2885	chlorophyll binding
SynRS9902_RS01660	COG0463	Glycosyl transferase, family 2
SynRS9902_RS01680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynRS9902_RS01690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynRS9902_RS01695	COG0254	rRNA binding
SynRS9902_RS01700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynRS9902_RS01705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynRS9902_RS01710	COG0101	tRNA pseudouridine synthase activity
SynRS9902_RS01715	COG0203	ribosomal protein L17
SynRS9902_RS01720	COG0202	RNA polymerase activity
SynRS9902_RS01725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynRS9902_RS01730	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynRS9902_RS01735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynRS9902_RS01740	COG0563	adenylate kinase activity
SynRS9902_RS01745	COG0201	protein transport
SynRS9902_RS01750	COG0200	Binds to the 23S rRNA
SynRS9902_RS01755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynRS9902_RS01760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynRS9902_RS01765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynRS9902_RS01770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynRS9902_RS01775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynRS9902_RS01780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynRS9902_RS01785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynRS9902_RS01790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynRS9902_RS01795	COG0255	Belongs to the universal ribosomal protein uL29 family
SynRS9902_RS01800	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynRS9902_RS01805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynRS9902_RS01810	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynRS9902_RS01815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynRS9902_RS01820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynRS9902_RS01825	COG0089	rRNA binding
SynRS9902_RS01830	COG0088	Forms part of the polypeptide exit tunnel
SynRS9902_RS01835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynRS9902_RS01850	COG3854	ATPases associated with a variety of cellular activities
SynRS9902_RS01865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynRS9902_RS01895	COG3001	Fructosamine kinase
SynRS9902_RS01915	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynRS9902_RS01920	COG1606	tRNA processing
SynRS9902_RS01925	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynRS9902_RS01930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynRS9902_RS01945	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynRS9902_RS01950	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynRS9902_RS01955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynRS9902_RS01970	COG0772	Belongs to the SEDS family
SynRS9902_RS01975	COG0489	protein tyrosine kinase activity
SynRS9902_RS01980	COG0408	coproporphyrinogen oxidase activity
SynRS9902_RS02000	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynRS9902_RS02040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynRS9902_RS02045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynRS9902_RS02050	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynRS9902_RS02050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynRS9902_RS02055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynRS9902_RS02210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynRS9902_RS02275	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SynRS9902_RS02310	COG1070	Carbohydrate kinase
SynRS9902_RS02315	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynRS9902_RS02325	COG0539	negative regulation of cytoplasmic translation
SynRS9902_RS02330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynRS9902_RS02355	COG0589	response to stress
SynRS9902_RS02365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynRS9902_RS02365	COG0758	DNA mediated transformation
SynRS9902_RS02370	COG2890	protein-(glutamine-N5) methyltransferase activity
SynRS9902_RS02375	COG0009	L-threonylcarbamoyladenylate synthase
SynRS9902_RS02395	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynRS9902_RS02400	COG2894	cell division
SynRS9902_RS02405	COG0850	regulation of cytokinetic process
SynRS9902_RS02410	COG1078	dGTPase activity
SynRS9902_RS02415	COG0793	Belongs to the peptidase S41A family
SynRS9902_RS02420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynRS9902_RS02425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynRS9902_RS02510	COG1570	exodeoxyribonuclease VII activity
SynRS9902_RS02525	COG1643	Atp-dependent helicase
SynRS9902_RS02540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynRS9902_RS02550	COG0488	(ABC) transporter
SynRS9902_RS02575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynRS9902_RS02580	COG0569	domain protein
SynRS9902_RS02585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynRS9902_RS02590	COG3273	potassium ion transport
SynRS9902_RS02590	COG0471	metal ion transport
SynRS9902_RS02595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynRS9902_RS02600	COG1252	NADH dehydrogenase
SynRS9902_RS02605	COG0175	sulfate reduction
SynRS9902_RS02610	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynRS9902_RS02615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynRS9902_RS02630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynRS9902_RS02640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynRS9902_RS02650	COG0033	Phosphoglucomutase
SynRS9902_RS02670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynRS9902_RS02690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynRS9902_RS02710	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynRS9902_RS02715	COG0719	Fe-S assembly protein
SynRS9902_RS02720	COG0396	ATPase activity
SynRS9902_RS02725	COG0719	Fe-S assembly protein
SynRS9902_RS02730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynRS9902_RS02745	COG0242	peptide deformylase activity
SynRS9902_RS02770	COG0537	adenosine 5'-monophosphoramidase activity
SynRS9902_RS02775	COG4178	(ABC) transporter
SynRS9902_RS02780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynRS9902_RS02795	COG0515	serine threonine protein kinase
SynRS9902_RS02810	COG0439	Biotin carboxylase
SynRS9902_RS02825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynRS9902_RS02835	COG1196	nuclear chromosome segregation
SynRS9902_RS02855	COG0116	Belongs to the methyltransferase superfamily
SynRS9902_RS02975	COG2089	acid synthase
SynRS9902_RS02995	COG1083	cytidylyl-transferase
SynRS9902_RS03005	COG3562	capsule polysaccharide
SynRS9902_RS03015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynRS9902_RS03030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynRS9902_RS03085	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynRS9902_RS03090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynRS9902_RS03095	COG1215	transferase activity, transferring glycosyl groups
SynRS9902_RS03115	COG1216	Glycosyl transferase, family 2
SynRS9902_RS03135	COG3754	Rhamnan synthesis protein F
SynRS9902_RS03160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynRS9902_RS03165	COG1333	cytochrome c biogenesis protein
SynRS9902_RS03175	COG0772	Belongs to the SEDS family
SynRS9902_RS03205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynRS9902_RS03210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynRS9902_RS03220	COG0356	it plays a direct role in the translocation of protons across the membrane
SynRS9902_RS03225	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynRS9902_RS03230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynRS9902_RS03235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynRS9902_RS03240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynRS9902_RS03245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynRS9902_RS03250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynRS9902_RS03260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynRS9902_RS03270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynRS9902_RS03275	COG3012	SEC-C Motif Domain Protein
SynRS9902_RS03285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynRS9902_RS03285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynRS9902_RS03290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynRS9902_RS03295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynRS9902_RS03300	COG1253	flavin adenine dinucleotide binding
SynRS9902_RS03305	COG0006	proline dipeptidase activity
SynRS9902_RS03310	COG0387	Pfam Sodium calcium exchanger
SynRS9902_RS03325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynRS9902_RS03330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynRS9902_RS03335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynRS9902_RS03340	COG0459	protein refolding
SynRS9902_RS03370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynRS9902_RS03375	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynRS9902_RS03390	COG0443	Heat shock 70 kDa protein
SynRS9902_RS03425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynRS9902_RS03445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynRS9902_RS03450	COG2264	protein methyltransferase activity
SynRS9902_RS03465	COG2010	Cytochrome c
SynRS9902_RS03470	COG1234	tRNA 3'-trailer cleavage
SynRS9902_RS03475	COG2385	sporulation resulting in formation of a cellular spore
SynRS9902_RS03475	COG2247	cell wall binding repeat
SynRS9902_RS03480	COG0363	glucosamine-6-phosphate deaminase activity
SynRS9902_RS03495	COG0217	transcriptional regulatory protein
SynRS9902_RS03500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynRS9902_RS03510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynRS9902_RS03515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynRS9902_RS03525	COG4251	negative regulation of phosphorylation
SynRS9902_RS03530	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynRS9902_RS03535	COG5002	protein histidine kinase activity
SynRS9902_RS03540	COG0151	Belongs to the GarS family
SynRS9902_RS03550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynRS9902_RS03560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynRS9902_RS03565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynRS9902_RS03570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynRS9902_RS03580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynRS9902_RS03620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynRS9902_RS03680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynRS9902_RS03695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SynRS9902_RS03700	COG0284	orotidine-5'-phosphate decarboxylase activity
SynRS9902_RS03705	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynRS9902_RS03730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynRS9902_RS03735	COG2211	Major facilitator Superfamily
SynRS9902_RS03755	COG0776	regulation of translation
SynRS9902_RS03760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynRS9902_RS03785	COG1053	succinate dehydrogenase
SynRS9902_RS03815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynRS9902_RS03825	COG0195	Participates in both transcription termination and antitermination
SynRS9902_RS03830	COG0779	Required for maturation of 30S ribosomal subunits
SynRS9902_RS03840	COG0641	radical SAM
SynRS9902_RS03855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynRS9902_RS03860	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynRS9902_RS03865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynRS9902_RS03870	COG0268	Binds directly to 16S ribosomal RNA
SynRS9902_RS03875	COG0084	hydrolase, TatD family'
SynRS9902_RS03880	COG0085	RNA polymerase activity
SynRS9902_RS03885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynRS9902_RS03890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynRS9902_RS03895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynRS9902_RS03900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynRS9902_RS03935	COG0357	Ribosomal RNA small subunit methyltransferase G
SynRS9902_RS03950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynRS9902_RS03965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynRS9902_RS03980	COG0156	8-amino-7-oxononanoate synthase activity
SynRS9902_RS03985	COG0385	Bile acid
SynRS9902_RS03995	COG4581	dead DEAH box helicase
SynRS9902_RS04000	COG0114	fumarate hydratase activity
SynRS9902_RS04030	COG1088	dTDP-glucose 4,6-dehydratase activity
SynRS9902_RS04035	COG1091	dTDP-4-dehydrorhamnose reductase activity
SynRS9902_RS04050	COG0438	transferase activity, transferring glycosyl groups
SynRS9902_RS04050	COG1216	Glycosyl transferase, family 2
SynRS9902_RS04055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynRS9902_RS04070	COG1376	ErfK ybiS ycfS ynhG family protein
SynRS9902_RS04075	COG1160	GTP binding
SynRS9902_RS04080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynRS9902_RS04090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynRS9902_RS04095	COG1799	cell septum assembly
SynRS9902_RS04100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynRS9902_RS04110	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynRS9902_RS04130	COG0438	transferase activity, transferring glycosyl groups
SynRS9902_RS04140	COG1381	Involved in DNA repair and RecF pathway recombination
SynRS9902_RS04150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynRS9902_RS04155	COG0321	lipoyl(octanoyl) transferase activity
SynRS9902_RS04160	COG1022	Amp-dependent synthetase and ligase
SynRS9902_RS04175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynRS9902_RS04180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynRS9902_RS04210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynRS9902_RS04215	COG0440	acetolactate synthase activity
SynRS9902_RS04245	COG2226	methyltransferase
SynRS9902_RS04255	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynRS9902_RS04260	COG0492	ferredoxin-NADP+ reductase activity
SynRS9902_RS04310	COG3411	Ferredoxin
SynRS9902_RS04315	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynRS9902_RS04320	COG0733	neurotransmitter:sodium symporter activity
SynRS9902_RS04340	COG0463	Glycosyl transferase, family 2
SynRS9902_RS04350	COG0215	cysteine-tRNA ligase activity
SynRS9902_RS04355	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynRS9902_RS04355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynRS9902_RS04360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynRS9902_RS04365	COG0012	GTP binding
SynRS9902_RS04385	COG0601	transmembrane transport
SynRS9902_RS04390	COG0747	negative chemotaxis
SynRS9902_RS04400	COG0460	homoserine dehydrogenase
SynRS9902_RS04405	COG2166	iron-sulfur cluster assembly
SynRS9902_RS04415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynRS9902_RS04420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynRS9902_RS04425	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynRS9902_RS04440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynRS9902_RS04445	COG2010	Cytochrome c
SynRS9902_RS04450	COG0742	ribosomal rna small subunit methyltransferase
SynRS9902_RS04455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynRS9902_RS04460	COG3118	belongs to the thioredoxin family
SynRS9902_RS04465	COG0516	GMP reductase activity
SynRS9902_RS04470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynRS9902_RS04475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynRS9902_RS04480	COG0644	oxidoreductase
SynRS9902_RS04485	COG1543	Belongs to the glycosyl hydrolase 57 family
SynRS9902_RS04490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynRS9902_RS04495	COG0395	ABC-type sugar transport system, permease component
SynRS9902_RS04525	COG0011	TIGRFAM Protein of
SynRS9902_RS04535	COG0564	pseudouridine synthase activity
SynRS9902_RS04540	COG1480	7TM receptor with intracellular HD hydrolase
SynRS9902_RS04545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynRS9902_RS04565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynRS9902_RS04580	COG1254	Belongs to the acylphosphatase family
SynRS9902_RS04585	COG1797	cobyrinic acid a,c-diamide synthase activity
SynRS9902_RS04595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynRS9902_RS04615	COG2205	protein histidine kinase activity
SynRS9902_RS04630	COG0308	aminopeptidase N
SynRS9902_RS04690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynRS9902_RS04700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynRS9902_RS04760	COG0717	Belongs to the dCTP deaminase family
SynRS9902_RS04765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynRS9902_RS04800	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynRS9902_RS04810	COG2197	response regulator
SynRS9902_RS04815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynRS9902_RS04830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynRS9902_RS04845	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynRS9902_RS04850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynRS9902_RS04855	COG0473	3-isopropylmalate dehydrogenase activity
SynRS9902_RS04860	COG3954	Phosphoribulokinase
SynRS9902_RS04870	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynRS9902_RS04875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynRS9902_RS04885	COG0673	inositol 2-dehydrogenase activity
SynRS9902_RS04890	COG0191	fructose-bisphosphate aldolase activity
SynRS9902_RS04900	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynRS9902_RS04905	COG0047	phosphoribosylformylglycinamidine synthase activity
SynRS9902_RS04910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynRS9902_RS04925	COG0668	transmembrane transport
SynRS9902_RS04935	COG0640	Transcriptional regulator
SynRS9902_RS04940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynRS9902_RS04960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynRS9902_RS05010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynRS9902_RS05020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynRS9902_RS05025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynRS9902_RS05035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynRS9902_RS05040	COG1429	ligase activity, forming nitrogen-metal bonds
SynRS9902_RS05050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynRS9902_RS05055	COG0149	triose-phosphate isomerase activity
SynRS9902_RS05065	COG1132	(ABC) transporter
SynRS9902_RS05075	COG1115	amino acid carrier protein
SynRS9902_RS05085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynRS9902_RS05095	COG0799	negative regulation of ribosome biogenesis
SynRS9902_RS05135	COG0659	secondary active sulfate transmembrane transporter activity
SynRS9902_RS05145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynRS9902_RS05150	COG4597	amino acid ABC transporter
SynRS9902_RS05155	COG0765	amino acid transport
SynRS9902_RS05160	COG1126	abc transporter atp-binding protein
SynRS9902_RS05195	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynRS9902_RS05270	COG0735	belongs to the Fur family
SynRS9902_RS05285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynRS9902_RS05320	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynRS9902_RS05480	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynRS9902_RS05490	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynRS9902_RS05570	COG1596	polysaccharide export
SynRS9902_RS05585	COG1132	(ABC) transporter
SynRS9902_RS05595	COG0297	glycogen (starch) synthase activity
SynRS9902_RS05600	COG0110	maltose O-acetyltransferase activity
SynRS9902_RS05605	COG0463	Glycosyl transferase, family 2
SynRS9902_RS05610	COG0297	glycogen (starch) synthase activity
SynRS9902_RS05680	COG0745	RESPONSE REGULATOR receiver
SynRS9902_RS05690	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynRS9902_RS05695	COG0271	Belongs to the BolA IbaG family
SynRS9902_RS05710	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynRS9902_RS05730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynRS9902_RS05740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynRS9902_RS05745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynRS9902_RS05760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynRS9902_RS05770	COG0513	Belongs to the DEAD box helicase family
SynRS9902_RS05785	COG0724	RNA recognition motif
SynRS9902_RS05795	COG1132	(ABC) transporter
SynRS9902_RS05800	COG0589	response to stress
SynRS9902_RS05800	COG0475	glutathione-regulated potassium exporter activity
SynRS9902_RS05815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynRS9902_RS05820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynRS9902_RS05830	COG0625	glutathione transferase activity
SynRS9902_RS05835	COG1054	Belongs to the UPF0176 family
SynRS9902_RS05850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynRS9902_RS05855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynRS9902_RS05860	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynRS9902_RS05865	COG0019	diaminopimelate decarboxylase activity
SynRS9902_RS05875	COG0542	response to heat
SynRS9902_RS05880	COG0371	Dehydrogenase
SynRS9902_RS05885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SynRS9902_RS05885	COG0596	Alpha beta hydrolase
SynRS9902_RS05885	COG2226	methyltransferase
SynRS9902_RS05895	COG0575	Belongs to the CDS family
SynRS9902_RS05900	COG1982	Orn Lys Arg decarboxylase major
SynRS9902_RS05905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynRS9902_RS05915	COG0745	RESPONSE REGULATOR receiver
SynRS9902_RS05920	COG5002	protein histidine kinase activity
SynRS9902_RS05925	COG1187	pseudouridine synthase activity
SynRS9902_RS05935	COG1640	4-alpha-glucanotransferase
SynRS9902_RS05955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynRS9902_RS05970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynRS9902_RS06000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynRS9902_RS06005	COG1121	(ABC) transporter
SynRS9902_RS06030	COG0701	Predicted permease
SynRS9902_RS06070	COG3659	wide pore channel activity
SynRS9902_RS06075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynRS9902_RS06085	COG1840	ABC-type Fe3 transport system, periplasmic component
SynRS9902_RS06090	COG3128	pkhd-type hydroxylase
SynRS9902_RS06100	COG3659	wide pore channel activity
SynRS9902_RS06130	COG0523	cobalamin synthesis protein
SynRS9902_RS06190	COG0405	Gamma-glutamyltransferase
SynRS9902_RS06265	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynRS9902_RS06270	COG1611	Belongs to the LOG family
SynRS9902_RS06335	COG2124	cytochrome p450
SynRS9902_RS06430	COG0463	Glycosyl transferase, family 2
SynRS9902_RS06440	COG0724	RNA recognition motif
SynRS9902_RS06460	COG2032	superoxide dismutase activity
SynRS9902_RS06550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynRS9902_RS06555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynRS9902_RS06560	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynRS9902_RS06565	COG1121	(ABC) transporter
SynRS9902_RS06575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynRS9902_RS06590	COG1119	ATPase activity
SynRS9902_RS06625	COG2226	methyltransferase
SynRS9902_RS06750	COG1201	RNA secondary structure unwinding
SynRS9902_RS06755	COG1793	dna ligase
SynRS9902_RS06780	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SynRS9902_RS06810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynRS9902_RS06815	COG1175	transmembrane transport
SynRS9902_RS06820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynRS9902_RS06875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynRS9902_RS06900	COG0740	serine-type endopeptidase activity
SynRS9902_RS06910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynRS9902_RS06915	COG0577	efflux transmembrane transporter activity
SynRS9902_RS06915	COG1136	(ABC) transporter
SynRS9902_RS06920	COG0469	pyruvate kinase activity
SynRS9902_RS06935	COG0762	integral membrane protein
SynRS9902_RS06945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynRS9902_RS06950	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynRS9902_RS06955	COG0644	oxidoreductase
SynRS9902_RS06985	COG0395	ABC-type sugar transport system, permease component
SynRS9902_RS06990	COG1175	transmembrane transport
SynRS9902_RS06995	COG1653	transport
SynRS9902_RS07000	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynRS9902_RS07005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynRS9902_RS07010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynRS9902_RS07015	COG0326	Molecular chaperone. Has ATPase activity
SynRS9902_RS07025	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynRS9902_RS07030	COG0483	inositol monophosphate 1-phosphatase activity
SynRS9902_RS07045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynRS9902_RS07050	COG0581	inorganic phosphate transmembrane transporter activity
SynRS9902_RS07055	COG0573	inorganic phosphate transmembrane transporter activity
SynRS9902_RS07060	COG0443	Heat shock 70 kDa protein
SynRS9902_RS07065	COG0484	heat shock protein binding
SynRS9902_RS07075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynRS9902_RS07080	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynRS9902_RS07085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynRS9902_RS07090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynRS9902_RS07090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynRS9902_RS07095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynRS9902_RS07100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynRS9902_RS07135	COG0166	Belongs to the GPI family
SynRS9902_RS07140	COG0495	leucyl-tRNA aminoacylation
SynRS9902_RS07150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynRS9902_RS07155	COG1104	cysteine desulfurase activity
SynRS9902_RS07170	COG2027	D-alanyl-D-alanine carboxypeptidase
SynRS9902_RS07180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynRS9902_RS07190	COG0322	excinuclease ABC activity
SynRS9902_RS07200	COG3046	protein related to deoxyribodipyrimidine photolyase
SynRS9902_RS07205	COG1981	membrane
SynRS9902_RS07225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynRS9902_RS07230	COG1410	methionine synthase
SynRS9902_RS07230	COG0646	methionine synthase
SynRS9902_RS07255	COG2385	sporulation resulting in formation of a cellular spore
SynRS9902_RS07295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynRS9902_RS07300	COG0072	phenylalanine-tRNA ligase activity
SynRS9902_RS07305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynRS9902_RS07310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynRS9902_RS07315	COG0557	exoribonuclease II activity
SynRS9902_RS07325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynRS9902_RS07360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynRS9902_RS07365	COG0739	heme binding
SynRS9902_RS07380	COG0450	alkyl hydroperoxide reductase
SynRS9902_RS07385	COG1615	UPF0182 protein
SynRS9902_RS07390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynRS9902_RS07395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynRS9902_RS07410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynRS9902_RS07415	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynRS9902_RS07415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynRS9902_RS07430	COG2119	membrane
SynRS9902_RS07440	COG0557	exoribonuclease II activity
SynRS9902_RS07445	COG0163	prenyltransferase activity
SynRS9902_RS07460	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynRS9902_RS07510	COG0312	modulator of DNA gyrase
SynRS9902_RS07520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynRS9902_RS07535	COG0861	Integral membrane protein TerC family
SynRS9902_RS07605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynRS9902_RS07615	COG0793	Belongs to the peptidase S41A family
SynRS9902_RS07620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynRS9902_RS07625	COG1573	uracil-dna glycosylase
SynRS9902_RS07635	COG0436	Aminotransferase
SynRS9902_RS07640	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynRS9902_RS07645	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynRS9902_RS07675	COG1836	PFAM Integral membrane protein DUF92
SynRS9902_RS07695	COG1122	ATPase activity
SynRS9902_RS07700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynRS9902_RS07715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynRS9902_RS07720	COG4106	trans-aconitate 2-methyltransferase activity
SynRS9902_RS07760	COG4974	Belongs to the 'phage' integrase family
SynRS9902_RS07790	COG1216	Glycosyl transferase, family 2
SynRS9902_RS07790	COG0463	Glycosyl transferase, family 2
SynRS9902_RS07820	COG0300	oxidoreductase activity
SynRS9902_RS07855	COG1357	PFAM Pentapeptide repeats (8 copies)
SynRS9902_RS07860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynRS9902_RS07870	COG0129	dihydroxy-acid dehydratase activity
SynRS9902_RS07885	COG0363	glucosamine-6-phosphate deaminase activity
SynRS9902_RS07890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynRS9902_RS07895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynRS9902_RS07900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynRS9902_RS07905	COG1494	fructose-1,6-bisphosphatase
SynRS9902_RS07910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynRS9902_RS07920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynRS9902_RS07930	COG1137	ATPase activity
SynRS9902_RS07945	COG1217	gtp-binding protein TYPA
SynRS9902_RS07950	COG0826	peptidase U32
SynRS9902_RS07960	COG0644	oxidoreductase
SynRS9902_RS07970	COG0751	glycine-tRNA ligase activity
SynRS9902_RS07975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynRS9902_RS07980	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynRS9902_RS07985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynRS9902_RS07995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynRS9902_RS08000	COG0052	Belongs to the universal ribosomal protein uS2 family
SynRS9902_RS08005	COG1216	Glycosyl transferase, family 2
SynRS9902_RS08035	COG0612	Peptidase, M16
SynRS9902_RS08055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynRS9902_RS08065	COG0076	glutamate decarboxylase activity
SynRS9902_RS08075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynRS9902_RS08085	COG0174	glutamine synthetase
SynRS9902_RS08090	COG2226	methyltransferase
SynRS9902_RS08115	COG0515	serine threonine protein kinase
SynRS9902_RS08120	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynRS9902_RS08130	COG0628	permease
SynRS9902_RS08155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynRS9902_RS08160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynRS9902_RS08165	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynRS9902_RS08165	COG0022	dehydrogenase e1 component
SynRS9902_RS08175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynRS9902_RS08180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynRS9902_RS08235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynRS9902_RS08255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynRS9902_RS08275	COG0358	DNA primase activity
SynRS9902_RS08290	COG0632	four-way junction helicase activity
SynRS9902_RS08295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynRS9902_RS08305	COG0587	DNA-directed DNA polymerase activity
SynRS9902_RS08310	COG0154	amidase activity
SynRS9902_RS08320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynRS9902_RS08325	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynRS9902_RS08335	COG0505	Belongs to the CarA family
SynRS9902_RS08340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynRS9902_RS08345	COG1132	(ABC) transporter
SynRS9902_RS08360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynRS9902_RS08380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynRS9902_RS08400	COG2176	DNA-directed DNA polymerase activity
SynRS9902_RS08405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynRS9902_RS08415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynRS9902_RS08420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynRS9902_RS08425	COG0142	geranyltranstransferase activity
SynRS9902_RS08430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynRS9902_RS08445	COG2045	Belongs to the ComB family
SynRS9902_RS08450	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynRS9902_RS08455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynRS9902_RS08465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynRS9902_RS08470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynRS9902_RS08480	COG0297	glycogen (starch) synthase activity
SynRS9902_RS08485	COG1376	ErfK ybiS ycfS ynhG family protein
SynRS9902_RS08490	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynRS9902_RS08495	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynRS9902_RS08500	COG0681	Belongs to the peptidase S26 family
SynRS9902_RS08520	COG0798	PFAM Bile acid sodium symporter
SynRS9902_RS08525	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynRS9902_RS08530	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynRS9902_RS08660	COG0484	heat shock protein binding
SynRS9902_RS08700	COG0010	Belongs to the arginase family
SynRS9902_RS08705	COG0375	protein maturation
SynRS9902_RS08720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynRS9902_RS08725	COG1116	anion transmembrane transporter activity
SynRS9902_RS08810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynRS9902_RS08935	COG0180	Tryptophanyl-tRNA synthetase
SynRS9902_RS08950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynRS9902_RS08960	COG0837	glucose binding
SynRS9902_RS08965	COG0083	homoserine kinase activity
SynRS9902_RS08970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9902_RS08975	COG0339	signal peptide processing
SynRS9902_RS08990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynRS9902_RS09030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynRS9902_RS09035	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynRS9902_RS09045	COG3794	PFAM blue (type 1) copper domain protein
SynRS9902_RS09095	COG0542	response to heat
SynRS9902_RS09105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynRS9902_RS09105	COG0140	phosphoribosyl-ATP diphosphatase activity
SynRS9902_RS09125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9902_RS09160	COG2010	Cytochrome c
SynRS9902_RS09175	COG0159	tryptophan synthase activity
SynRS9902_RS09200	COG0418	dihydroorotase activity
SynRS9902_RS09205	COG0659	secondary active sulfate transmembrane transporter activity
SynRS9902_RS09225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynRS9902_RS09230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynRS9902_RS09235	COG1845	cytochrome c oxidase, subunit III
SynRS9902_RS09245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynRS9902_RS09265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynRS9902_RS09270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynRS9902_RS09285	COG0456	acetyltransferase
SynRS9902_RS09290	COG1132	(ABC) transporter
SynRS9902_RS09295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynRS9902_RS09300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynRS9902_RS09305	COG0251	oxidation-reduction process
SynRS9902_RS09555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynRS9902_RS09570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynRS9902_RS09575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynRS9902_RS09580	COG2135	peptidase activity
SynRS9902_RS09635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynRS9902_RS09650	COG3659	wide pore channel activity
SynRS9902_RS09675	COG0798	PFAM Bile acid sodium symporter
SynRS9902_RS09685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynRS9902_RS09685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynRS9902_RS09730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynRS9902_RS09735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynRS9902_RS09740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynRS9902_RS09750	COG0196	riboflavin kinase activity
SynRS9902_RS09755	COG0352	thiamine-phosphate diphosphorylase activity
SynRS9902_RS09775	COG1691	(AIR) carboxylase
SynRS9902_RS09785	COG0336	Belongs to the RNA methyltransferase TrmD family
SynRS9902_RS09800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynRS9902_RS09815	COG0670	Belongs to the BI1 family
SynRS9902_RS09820	COG1702	phosphate starvation-inducible protein PhoH
SynRS9902_RS09825	COG0228	four-way junction DNA binding
SynRS9902_RS09830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynRS9902_RS09840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynRS9902_RS09845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9902_RS09850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynRS9902_RS09850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynRS9902_RS09855	COG0482	sulfurtransferase activity
SynRS9902_RS09860	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynRS9902_RS09890	COG0134	indole-3-glycerol-phosphate synthase activity
SynRS9902_RS09895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynRS9902_RS09900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynRS9902_RS09915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynRS9902_RS09920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynRS9902_RS09925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynRS9902_RS09930	COG0285	dihydrofolate synthase activity
SynRS9902_RS09935	COG1357	PFAM Pentapeptide repeats (8 copies)
SynRS9902_RS09965	COG4948	Mandelate Racemase Muconate Lactonizing
SynRS9902_RS09970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynRS9902_RS09975	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynRS9902_RS09990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynRS9902_RS10000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynRS9902_RS10005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynRS9902_RS10010	COG4956	integral membrane protein (PIN domain superfamily)
SynRS9902_RS10015	COG0740	serine-type endopeptidase activity
SynRS9902_RS10020	COG0740	serine-type endopeptidase activity
SynRS9902_RS10025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynRS9902_RS10035	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynRS9902_RS10040	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynRS9902_RS10070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SynRS9902_RS10070	COG2755	lipolytic protein G-D-S-L family
SynRS9902_RS10105	COG0582	viral genome integration into host DNA
SynRS9902_RS10120	COG0752	glycyl-tRNA synthetase alpha subunit
SynRS9902_RS10130	COG2226	methyltransferase
SynRS9902_RS10135	COG0107	imidazoleglycerol-phosphate synthase activity
SynRS9902_RS10145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynRS9902_RS10150	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynRS9902_RS10155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynRS9902_RS10155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynRS9902_RS10160	COG3695	enzyme binding
SynRS9902_RS10165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynRS9902_RS10180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SynRS9902_RS10185	COG5002	protein histidine kinase activity
SynRS9902_RS10190	COG0481	GTPase activity
SynRS9902_RS10200	COG0579	oxidoreductase
SynRS9902_RS10205	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynRS9902_RS10245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynRS9902_RS10255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynRS9902_RS10260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynRS9902_RS10275	COG0424	maF-like protein
SynRS9902_RS10285	COG1492	cobalamin metabolic process
SynRS9902_RS10315	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9902_RS10320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynRS9902_RS10325	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynRS9902_RS10355	COG4451	ribulose bisphosphate carboxylase, small
SynRS9902_RS10360	COG1850	ribulose-bisphosphate carboxylase activity
SynRS9902_RS10365	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynRS9902_RS10370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynRS9902_RS10375	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynRS9902_RS10385	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynRS9902_RS10390	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynRS9902_RS10395	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynRS9902_RS10425	COG0730	response to heat
SynRS9902_RS10430	COG0095	Lipoate-protein ligase
SynRS9902_RS10435	COG0517	IMP dehydrogenase activity
SynRS9902_RS10435	COG1994	Peptidase M50
SynRS9902_RS10440	COG0135	phosphoribosylanthranilate isomerase activity
SynRS9902_RS10445	COG0302	gtp cyclohydrolase
SynRS9902_RS10455	COG0825	malonyl-CoA metabolic process
SynRS9902_RS10460	COG5322	oxidoreductase activity
SynRS9902_RS10465	COG3396	Phenylacetate-CoA oxygenase
SynRS9902_RS10475	COG0539	negative regulation of cytoplasmic translation
SynRS9902_RS10490	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynRS9902_RS10510	COG0028	Belongs to the TPP enzyme family
SynRS9902_RS10515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynRS9902_RS10525	COG2226	methyltransferase
SynRS9902_RS10540	COG0528	UMP kinase activity
SynRS9902_RS10545	COG0233	cytoplasmic translational termination
SynRS9902_RS10555	COG0415	Belongs to the DNA photolyase family
SynRS9902_RS10570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynRS9902_RS10575	COG0768	penicillin binding
SynRS9902_RS10590	COG0588	phosphoglycerate mutase activity
SynRS9902_RS10620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynRS9902_RS10635	COG0442	prolyl-tRNA aminoacylation
SynRS9902_RS10645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynRS9902_RS10650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynRS9902_RS10660	COG2099	Precorrin-6x reductase
SynRS9902_RS10680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynRS9902_RS10690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynRS9902_RS10695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9902_RS10705	COG0181	hydroxymethylbilane synthase activity
SynRS9902_RS10720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynRS9902_RS10735	COG0432	Pfam Uncharacterised protein family UPF0047
SynRS9902_RS10740	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynRS9902_RS10745	COG0523	cobalamin synthesis protein
SynRS9902_RS10755	COG3842	ATPase activity
SynRS9902_RS10775	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynRS9902_RS10800	COG0708	Exodeoxyribonuclease III
SynRS9902_RS10805	COG0277	FAD linked oxidase domain protein
SynRS9902_RS10810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynRS9902_RS10820	COG0295	cytidine deaminase activity
SynRS9902_RS10830	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynRS9902_RS10845	COG1666	GTP binding
SynRS9902_RS10860	COG0857	belongs to the CobB CobQ family
SynRS9902_RS10870	COG3000	fatty acid hydroxylase
SynRS9902_RS10870	COG0300	oxidoreductase activity
SynRS9902_RS10875	COG0024	Methionine aminopeptidase
SynRS9902_RS10885	COG0335	large ribosomal subunit rRNA binding
SynRS9902_RS10905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynRS9902_RS10925	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynRS9902_RS10935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynRS9902_RS10940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynRS9902_RS10955	COG0194	GDP metabolic process
SynRS9902_RS10960	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynRS9902_RS10965	COG0805	protein transport
SynRS9902_RS10975	COG0723	plastoquinol--plastocyanin reductase activity
SynRS9902_RS10980	COG0739	heme binding
SynRS9902_RS10985	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynRS9902_RS10990	COG2875	Belongs to the precorrin methyltransferase family
SynRS9902_RS11005	COG0248	Ppx GppA phosphatase
SynRS9902_RS11010	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynRS9902_RS11015	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynRS9902_RS11020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynRS9902_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
SynRS9902_RS11045	COG0459	protein refolding
SynRS9902_RS11050	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynRS9902_RS11070	COG0109	protoheme IX farnesyltransferase activity
SynRS9902_RS11075	COG1612	heme a metabolic process
SynRS9902_RS11080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynRS9902_RS11085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynRS9902_RS11090	COG1845	cytochrome c oxidase, subunit III
SynRS9902_RS11120	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynRS9902_RS11135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynRS9902_RS11140	COG1007	ATP synthesis coupled electron transport
SynRS9902_RS11145	COG1136	(ABC) transporter
SynRS9902_RS11145	COG0577	efflux transmembrane transporter activity
SynRS9902_RS11155	COG2205	protein histidine kinase activity
SynRS9902_RS11170	COG0739	heme binding
SynRS9902_RS11175	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynRS9902_RS11175	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynRS9902_RS11180	COG0436	Aminotransferase
SynRS9902_RS11185	COG3118	belongs to the thioredoxin family
SynRS9902_RS11190	COG1842	Phage shock protein A
SynRS9902_RS11205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynRS9902_RS11215	COG0697	spore germination
SynRS9902_RS11220	COG0616	signal peptide processing
SynRS9902_RS11235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynRS9902_RS11240	COG0594	ribonuclease P activity
SynRS9902_RS11250	COG0706	membrane insertase activity
SynRS9902_RS11260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynRS9902_RS11270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynRS9902_RS11275	COG0750	zinc metalloprotease
SynRS9902_RS11280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynRS9902_RS11285	COG1185	polyribonucleotide nucleotidyltransferase activity
SynRS9902_RS11295	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynRS9902_RS11470	COG1404	Belongs to the peptidase S8 family
SynRS9902_RS11580	COG2988	succinylglutamate desuccinylase activity
SynRS9902_RS11585	COG0435	Glutathione S-transferase
SynRS9902_RS11595	COG0488	(ABC) transporter
SynRS9902_RS11610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynRS9902_RS11615	COG3842	ATPase activity
SynRS9902_RS11620	COG1193	negative regulation of DNA recombination
SynRS9902_RS11630	COG0113	porphobilinogen synthase activity
SynRS9902_RS11635	COG0484	heat shock protein binding
SynRS9902_RS11640	COG4243	Vitamin k epoxide reductase
SynRS9902_RS11645	COG0659	secondary active sulfate transmembrane transporter activity
SynRS9902_RS11655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynRS9902_RS11675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynRS9902_RS11680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynRS9902_RS11690	COG1012	belongs to the aldehyde dehydrogenase family
SynRS9902_RS11700	COG0514	ATP-dependent DNA helicase (RecQ)
SynRS9902_RS11715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynRS9902_RS11720	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynRS9902_RS11725	COG0235	Class ii aldolase
SynRS9902_RS11730	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynRS9902_RS11775	COG1968	undecaprenyl-diphosphatase activity
SynRS9902_RS11785	COG1555	photosystem II stabilization
SynRS9902_RS11790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynRS9902_RS11795	COG4243	Vitamin k epoxide reductase
SynRS9902_RS11800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynRS9902_RS11815	COG1032	radical SAM domain protein
SynRS9902_RS11845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynRS9902_RS11870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynRS9902_RS11875	COG1472	Belongs to the glycosyl hydrolase 3 family
SynRS9902_RS11880	COG0457	Tetratricopeptide repeat
SynRS9902_RS11880	COG0463	Glycosyl transferase, family 2
SynRS9902_RS11885	COG1587	Uroporphyrinogen-III synthase
SynRS9902_RS11900	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynRS9902_RS11905	COG0316	Belongs to the HesB IscA family
SynRS9902_RS11930	COG1090	epimerase
SynRS9902_RS11945	COG0484	heat shock protein binding
SynRS9902_RS11950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynRS9902_RS11955	COG3659	wide pore channel activity
SynRS9902_RS11960	COG3659	wide pore channel activity
SynRS9902_RS11970	COG0463	Glycosyl transferase, family 2
SynRS9902_RS12010	COG1122	ATPase activity
SynRS9902_RS12020	COG0745	RESPONSE REGULATOR receiver
SynRS9902_RS12030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynRS9902_RS12035	COG2217	Heavy metal translocating P-type atpase
SynRS9902_RS12040	COG3063	Type IV pilus biogenesis stability protein PilW
SynRS9902_RS12045	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynRS9902_RS12055	COG0416	fatty acid biosynthetic process
SynRS9902_RS12060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynRS9902_RS12065	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynRS9902_RS12080	COG1214	PFAM Peptidase M22, glycoprotease
SynRS9902_RS12090	COG0617	tRNA 3'-terminal CCA addition
SynRS9902_RS12095	COG0724	RNA recognition motif
SynRS9902_RS12100	COG1562	ergosterol biosynthetic process
SynRS9902_RS12105	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynRS9902_RS12105	COG0493	'glutamate synthase
SynRS9902_RS12120	COG0583	DNA-binding transcription factor activity
SynRS9902_RS12130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynRS9902_RS12135	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9902_RS12150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynRS9902_RS12160	COG2197	response regulator
SynRS9902_RS12170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynRS9902_RS12175	COG0713	ATP synthesis coupled electron transport
SynRS9902_RS12185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9902_RS12190	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynRS9902_RS12195	COG0372	Belongs to the citrate synthase family
SynRS9902_RS12215	COG1420	regulation of RNA biosynthetic process
SynRS9902_RS12220	COG0133	tryptophan synthase activity
SynRS9902_RS12225	COG0023	Translation Initiation Factor
SynRS9902_RS12230	COG0529	Catalyzes the synthesis of activated sulfate
SynRS9902_RS12250	COG0628	permease
SynRS9902_RS12260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynRS9902_RS12270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynRS9902_RS12275	COG0564	pseudouridine synthase activity
SynRS9902_RS12280	COG0745	RESPONSE REGULATOR receiver
SynRS9902_RS12290	COG1104	cysteine desulfurase activity
SynRS9902_RS12295	COG0275	rRNA processing
SynRS9902_RS12300	COG0649	NAD binding
SynRS9902_RS12315	COG0824	Thioesterase
SynRS9902_RS12325	COG0318	PFAM AMP-dependent synthetase and ligase
SynRS9902_RS12335	COG1575	Belongs to the MenA family. Type 1 subfamily
SynRS9902_RS12345	COG0189	ligase activity
SynRS9902_RS12350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynRS9902_RS12365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynRS9902_RS12370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynRS9902_RS12375	COG0512	Glutamine amidotransferase of anthranilate synthase
SynRS9902_RS12385	COG0252	asparaginase activity
SynRS9902_RS12390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynRS9902_RS12400	COG0018	arginyl-trna synthetase
SynRS9902_RS12405	COG0157	Belongs to the NadC ModD family
SynRS9902_RS12410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynRS9902_RS12420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynRS9902_RS12425	COG4172	Belongs to the ABC transporter superfamily
SynRS9902_RS12430	COG0564	pseudouridine synthase activity
SynRS9902_RS12435	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynRS9902_RS12440	COG0126	phosphoglycerate kinase activity
SynRS9902_RS12450	COG2084	Dehydrogenase
SynRS9902_RS12460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynRS9902_RS12465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynRS9902_RS12475	COG0167	dihydroorotate dehydrogenase activity
SynRS9902_RS12480	COG0328	RNA-DNA hybrid ribonuclease activity
SynRS9902_RS12490	COG0222	ribosome binding
SynRS9902_RS12495	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynRS9902_RS12500	COG0081	regulation of translation
SynRS9902_RS12505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynRS9902_RS12510	COG0250	Participates in transcription elongation, termination and antitermination
SynRS9902_RS12515	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynRS9902_RS12520	COG0542	response to heat
SynRS9902_RS12525	COG0346	lactoylglutathione lyase activity
SynRS9902_RS12530	COG0148	phosphopyruvate hydratase activity
SynRS9902_RS12535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynRS9902_RS12555	COG3119	arylsulfatase activity
SynRS9902_RS12560	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynRS9902_RS12565	COG0237	dephospho-CoA kinase activity
SynRS9902_RS12580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynRS9902_RS12590	COG2022	thiamine diphosphate biosynthetic process
SynRS9902_RS12590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynRS9902_RS12615	COG0105	UTP biosynthetic process
SynRS9902_RS12625	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SynRS9902_RS12635	COG1803	Methylglyoxal synthase
SynRS9902_RS12660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynRS9902_RS12670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynRS9902_RS12695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynRS9902_RS12695	COG0426	domain, Protein
SynRS9902_RS12705	COG0426	domain, Protein
SynRS9902_RS12705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynRS9902_RS12720	COG1741	Belongs to the pirin family
SynRS9902_RS12735	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynRS9902_RS12735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynRS9902_RS12740	COG0509	glycine decarboxylation via glycine cleavage system
SynRS9902_RS12745	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynRS9902_RS12755	COG0359	binds to the 23S rRNA
SynRS9902_RS12760	COG0305	Participates in initiation and elongation during chromosome replication
SynRS9902_RS12760	COG1372	Participates in initiation and elongation during chromosome replication
SynRS9902_RS12760	COG0305	Participates in initiation and elongation during chromosome replication
SynRS9902_RS12760	COG1372	Participates in initiation and elongation during chromosome replication
SynRS9902_RS12800	COG0445	tRNA wobble uridine modification
SynRS9902_RS12835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynRS9902_RS12845	COG0398	Pfam SNARE associated Golgi protein
SynRS9902_RS12865	COG0525	valine-tRNA ligase activity
SynRS9902_RS12895	COG4221	oxidoreductase activity
SynRS9902_RS12945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynRS9902_RS12965	COG3956	TIGRFAM MazG family protein
SynRS9902_RS12970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynRS9902_RS12975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynRS9902_RS12980	COG0010	Belongs to the arginase family
SynRS9902_RS12995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynRS9902_RS13000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynRS9902_RS13015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9902_RS13020	COG0504	CTP synthase activity
SynRS9902_RS13025	COG0602	queuosine metabolic process
SynRS9902_RS13030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SynRS9902_RS13035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynRS9902_RS13055	COG0366	Alpha amylase catalytic
SynRS9902_RS13060	COG0463	Glycosyl transferase, family 2
SynRS9902_RS13100	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynRS9902_RS13105	COG0830	nickel cation binding
SynRS9902_RS13110	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynRS9902_RS13115	COG0829	nickel cation binding
SynRS9902_RS13120	COG0831	urea catabolic process
SynRS9902_RS13125	COG0832	Belongs to the urease beta subunit family
SynRS9902_RS13130	COG0804	urea catabolic process
SynRS9902_RS13135	COG0519	Catalyzes the synthesis of GMP from XMP
SynRS9902_RS13135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynRS9902_RS13160	COG0367	asparagine synthase
SynRS9902_RS13165	COG0540	Belongs to the ATCase OTCase family
SynRS9902_RS13180	COG2308	Evidence 4 Homologs of previously reported genes of
SynRS9902_RS13200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynRS9902_RS13205	COG0746	molybdenum cofactor guanylyltransferase activity
SynRS9902_RS13215	COG0243	molybdopterin cofactor binding
SynRS9902_RS13235	COG0315	cyclic pyranopterin monophosphate synthase activity
SynRS9902_RS13240	COG0303	'Molybdopterin
SynRS9902_RS13255	COG0314	molybdopterin synthase activity
SynRS9902_RS13265	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynRS9902_RS13270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynRS9902_RS13285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynRS9902_RS13295	COG2116	formate transmembrane transporter activity
SynRS9902_RS13305	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynRS9902_RS13315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynRS9902_RS13330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynRS9902_RS13335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9902_RS13340	COG0170	dolichyl monophosphate biosynthetic process
SynRS9902_RS13345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynRS9902_RS13350	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynRS9902_RS13360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynRS9902_RS13370	COG0788	formyltetrahydrofolate deformylase activity
SynRS9902_RS13385	COG0443	Heat shock 70 kDa protein
SynRS9902_RS13390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynRS9902_RS13400	COG0360	Binds together with S18 to 16S ribosomal RNA
SynRS9902_RS13410	COG0137	argininosuccinate synthase activity
SynRS9902_RS13425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynRS9902_RS13450	COG1376	ErfK ybiS ycfS ynhG family protein
SynRS9902_RS13455	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynRS9902_RS13460	COG0438	transferase activity, transferring glycosyl groups
SynRS9902_RS13470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynRS9902_RS13475	COG0497	DNA recombination
SynRS9902_RS13480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynRS9902_RS13490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine