locus-tag	class	description
BM449_RS00010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM449_RS00020	COG0456	acetyltransferase
BM449_RS00025	COG0596	Alpha beta hydrolase
BM449_RS00030	COG1132	(ABC) transporter
BM449_RS00035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BM449_RS00040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM449_RS00045	COG3842	ATPase activity
BM449_RS00050	COG0251	oxidation-reduction process
BM449_RS00160	COG1205	dead DEAH box helicase
BM449_RS00160	COG1111	helicase
BM449_RS00200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BM449_RS00245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM449_RS00280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM449_RS00620	COG3657	addiction module killer protein
BM449_RS00625	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM449_RS00635	COG3415	Transposase
BM449_RS00635	COG2801	Transposase and inactivated derivatives
BM449_RS00645	COG0011	TIGRFAM Protein of
BM449_RS00805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BM449_RS00830	COG2814	Major facilitator Superfamily
BM449_RS00855	COG2801	Transposase and inactivated derivatives
BM449_RS00855	COG3415	Transposase
BM449_RS00860	COG0385	Bile acid
BM449_RS00890	COG0415	Belongs to the DNA photolyase family
BM449_RS00930	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM449_RS00935	COG3657	addiction module killer protein
BM449_RS00960	COG4974	Belongs to the 'phage' integrase family
BM449_RS00970	COG4974	Belongs to the 'phage' integrase family
BM449_RS00980	COG3046	protein related to deoxyribodipyrimidine photolyase
BM449_RS00985	COG0415	Belongs to the DNA photolyase family
BM449_RS01000	COG2124	cytochrome p450
BM449_RS01025	COG0730	response to heat
BM449_RS01030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM449_RS01055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM449_RS01060	COG0723	plastoquinol--plastocyanin reductase activity
BM449_RS01075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM449_RS01085	COG1294	oxidase, subunit
BM449_RS01090	COG1271	oxidase subunit
BM449_RS01110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BM449_RS01150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BM449_RS01185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BM449_RS01190	COG0732	type I restriction modification DNA specificity domain
BM449_RS01260	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM449_RS01265	COG2326	polyphosphate kinase activity
BM449_RS01315	COG2217	Heavy metal translocating P-type atpase
BM449_RS01365	COG1131	(ABC) transporter
BM449_RS01375	COG3264	Mechanosensitive ion channel
BM449_RS01375	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BM449_RS01410	COG4974	Belongs to the 'phage' integrase family
BM449_RS01420	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BM449_RS01500	COG0697	spore germination
BM449_RS01535	COG5002	protein histidine kinase activity
BM449_RS01600	COG2801	Transposase and inactivated derivatives
BM449_RS01600	COG3415	Transposase
BM449_RS01620	COG2826	transposase and inactivated derivatives, IS30 family
BM449_RS01650	COG4584	PFAM Integrase catalytic
BM449_RS01655	COG1484	DNA-dependent DNA replication
BM449_RS01675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BM449_RS01720	COG3588	fructose-bisphosphate aldolase
BM449_RS01725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BM449_RS01725	COG1793	dna ligase
BM449_RS01760	COG1793	dna ligase
BM449_RS01765	COG1201	RNA secondary structure unwinding
BM449_RS01780	COG0625	glutathione transferase activity
BM449_RS01790	COG0517	IMP dehydrogenase activity
BM449_RS01790	COG0516	GMP reductase activity
BM449_RS01795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BM449_RS01805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BM449_RS01815	COG2197	response regulator
BM449_RS01820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BM449_RS01825	COG0114	fumarate hydratase activity
BM449_RS01850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BM449_RS01865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BM449_RS01870	COG0668	transmembrane transport
BM449_RS01880	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM449_RS01885	COG0473	3-isopropylmalate dehydrogenase activity
BM449_RS01890	COG3954	Phosphoribulokinase
BM449_RS01900	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BM449_RS01905	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BM449_RS01920	COG0191	fructose-bisphosphate aldolase activity
BM449_RS01925	COG1615	UPF0182 protein
BM449_RS01930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BM449_RS01935	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BM449_RS01945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM449_RS01950	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BM449_RS01960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BM449_RS01960	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BM449_RS01975	COG2119	membrane
BM449_RS01985	COG0557	exoribonuclease II activity
BM449_RS01990	COG0163	prenyltransferase activity
BM449_RS02005	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BM449_RS02010	COG0312	modulator of DNA gyrase
BM449_RS02020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BM449_RS02075	COG2337	Toxic component of a toxin-antitoxin (TA) module
BM449_RS02090	COG4232	protein-disulfide reductase activity
BM449_RS02095	COG0785	Cytochrome C biogenesis protein
BM449_RS02100	COG0659	secondary active sulfate transmembrane transporter activity
BM449_RS02150	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BM449_RS02185	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BM449_RS02190	COG0271	Belongs to the BolA IbaG family
BM449_RS02205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BM449_RS02225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BM449_RS02235	COG1074	ATP-dependent DNA helicase activity
BM449_RS02240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM449_RS02260	COG0513	Belongs to the DEAD box helicase family
BM449_RS02280	COG1132	(ABC) transporter
BM449_RS02295	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BM449_RS02295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM449_RS02305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BM449_RS02310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BM449_RS02320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BM449_RS02345	COG1054	Belongs to the UPF0176 family
BM449_RS02350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BM449_RS02355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BM449_RS02360	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BM449_RS02365	COG0019	diaminopimelate decarboxylase activity
BM449_RS02375	COG0542	response to heat
BM449_RS02380	COG0371	Dehydrogenase
BM449_RS02400	COG0575	Belongs to the CDS family
BM449_RS02410	COG1982	Orn Lys Arg decarboxylase major
BM449_RS02415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM449_RS02425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_RS02430	COG1187	pseudouridine synthase activity
BM449_RS02445	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
BM449_RS02460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BM449_RS02470	COG0308	aminopeptidase N
BM449_RS02485	COG2205	protein histidine kinase activity
BM449_RS02505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BM449_RS02510	COG3409	Peptidoglycan-binding domain 1 protein
BM449_RS02510	COG3429	Glucose-6-phosphate dehydrogenase subunit
BM449_RS02515	COG1797	cobyrinic acid a,c-diamide synthase activity
BM449_RS02520	COG0406	alpha-ribazole phosphatase activity
BM449_RS02530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM449_RS02545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BM449_RS02550	COG1480	7TM receptor with intracellular HD hydrolase
BM449_RS02585	COG0799	negative regulation of ribosome biogenesis
BM449_RS02595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BM449_RS02610	COG1132	(ABC) transporter
BM449_RS02620	COG0149	triose-phosphate isomerase activity
BM449_RS02625	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BM449_RS02630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM449_RS02635	COG1131	(ABC) transporter
BM449_RS02640	COG0842	Transport permease protein
BM449_RS02640	COG1129	ABC transporter
BM449_RS02645	COG0842	Transport permease protein
BM449_RS02655	COG1649	PFAM Uncharacterised BCR, COG1649
BM449_RS02660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BM449_RS02665	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BM449_RS02675	COG0778	Nitroreductase
BM449_RS02680	COG0435	Glutathione S-transferase
BM449_RS02685	COG1429	ligase activity, forming nitrogen-metal bonds
BM449_RS02690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BM449_RS02700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BM449_RS02755	COG2326	polyphosphate kinase activity
BM449_RS02790	COG0438	transferase activity, transferring glycosyl groups
BM449_RS02795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM449_RS02800	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BM449_RS02810	COG0740	serine-type endopeptidase activity
BM449_RS02815	COG0740	serine-type endopeptidase activity
BM449_RS02820	COG4956	integral membrane protein (PIN domain superfamily)
BM449_RS02825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM449_RS02830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BM449_RS02840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BM449_RS02860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BM449_RS02865	COG4948	Mandelate Racemase Muconate Lactonizing
BM449_RS02885	COG0402	S-adenosylhomocysteine deaminase activity
BM449_RS02900	COG0285	dihydrofolate synthase activity
BM449_RS02905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BM449_RS02910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BM449_RS02915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BM449_RS02930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM449_RS02935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM449_RS02940	COG0134	indole-3-glycerol-phosphate synthase activity
BM449_RS02950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BM449_RS02955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BM449_RS02965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BM449_RS02970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BM449_RS02975	COG1104	cysteine desulfurase activity
BM449_RS02985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM449_RS02995	COG0706	membrane insertase activity
BM449_RS03005	COG0594	ribonuclease P activity
BM449_RS03010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BM449_RS03025	COG0616	signal peptide processing
BM449_RS03030	COG0697	spore germination
BM449_RS03035	COG0438	transferase activity, transferring glycosyl groups
BM449_RS03050	COG1842	Phage shock protein A
BM449_RS03055	COG3118	belongs to the thioredoxin family
BM449_RS03060	COG0436	Aminotransferase
BM449_RS03065	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BM449_RS03065	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BM449_RS03070	COG0739	heme binding
BM449_RS03075	COG1136	(ABC) transporter
BM449_RS03075	COG0577	efflux transmembrane transporter activity
BM449_RS03085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM449_RS03100	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BM449_RS03135	COG1845	cytochrome c oxidase, subunit III
BM449_RS03140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BM449_RS03155	COG0109	protoheme IX farnesyltransferase activity
BM449_RS03175	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BM449_RS03180	COG0459	protein refolding
BM449_RS03190	COG1028	Short-chain dehydrogenase reductase Sdr
BM449_RS03195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM449_RS03205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BM449_RS03210	COG1619	proteins homologs of microcin C7 resistance protein MccF
BM449_RS03215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BM449_RS03250	COG0739	heme binding
BM449_RS03255	COG0723	plastoquinol--plastocyanin reductase activity
BM449_RS03265	COG0805	protein transport
BM449_RS03270	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BM449_RS03275	COG0194	GDP metabolic process
BM449_RS03290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BM449_RS03310	COG0012	GTP binding
BM449_RS03355	COG0601	transmembrane transport
BM449_RS03370	COG0460	homoserine dehydrogenase
BM449_RS03375	COG2166	iron-sulfur cluster assembly
BM449_RS03390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BM449_RS03395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BM449_RS03400	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BM449_RS03415	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BM449_RS03420	COG2010	Cytochrome c
BM449_RS03435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BM449_RS03440	COG1611	Belongs to the LOG family
BM449_RS03445	COG3118	belongs to the thioredoxin family
BM449_RS03450	COG0516	GMP reductase activity
BM449_RS03455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM449_RS03465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BM449_RS03470	COG0644	oxidoreductase
BM449_RS03480	COG1543	Belongs to the glycosyl hydrolase 57 family
BM449_RS03490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BM449_RS03495	COG0395	ABC-type sugar transport system, permease component
BM449_RS03505	COG2119	membrane
BM449_RS03515	COG0861	Integral membrane protein TerC family
BM449_RS03530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BM449_RS03540	COG0793	Belongs to the peptidase S41A family
BM449_RS03545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BM449_RS03550	COG1573	uracil-dna glycosylase
BM449_RS03555	COG0436	Aminotransferase
BM449_RS03560	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BM449_RS03565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BM449_RS03565	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BM449_RS03570	COG3639	organic phosphonate transmembrane transporter activity
BM449_RS03580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_RS03585	COG1836	PFAM Integral membrane protein DUF92
BM449_RS03605	COG1122	ATPase activity
BM449_RS03610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BM449_RS03625	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BM449_RS03660	COG1091	dTDP-4-dehydrorhamnose reductase activity
BM449_RS03665	COG1088	dTDP-glucose 4,6-dehydratase activity
BM449_RS03700	COG0281	malic enzyme
BM449_RS03705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BM449_RS03730	COG0513	Belongs to the DEAD box helicase family
BM449_RS03740	COG2046	Belongs to the sulfate adenylyltransferase family
BM449_RS03740	COG0529	Catalyzes the synthesis of activated sulfate
BM449_RS03750	COG0529	Catalyzes the synthesis of activated sulfate
BM449_RS03770	COG0752	glycyl-tRNA synthetase alpha subunit
BM449_RS03775	COG2226	methyltransferase
BM449_RS03785	COG0107	imidazoleglycerol-phosphate synthase activity
BM449_RS03795	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BM449_RS03800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BM449_RS03805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BM449_RS03805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BM449_RS03810	COG3695	enzyme binding
BM449_RS03815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM449_RS03845	COG0745	RESPONSE REGULATOR receiver
BM449_RS03850	COG3850	Histidine kinase
BM449_RS03850	COG5002	protein histidine kinase activity
BM449_RS03890	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BM449_RS03895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BM449_RS03900	COG0750	zinc metalloprotease
BM449_RS03905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BM449_RS03910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BM449_RS03915	COG1185	polyribonucleotide nucleotidyltransferase activity
BM449_RS03920	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BM449_RS03950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM449_RS03955	COG0776	regulation of translation
BM449_RS03960	COG1523	belongs to the glycosyl hydrolase 13 family
BM449_RS03965	COG1119	ATPase activity
BM449_RS03990	COG2211	Major facilitator Superfamily
BM449_RS03995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BM449_RS04010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BM449_RS04015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BM449_RS04020	COG1799	cell septum assembly
BM449_RS04025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BM449_RS04035	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BM449_RS04040	COG1160	GTP binding
BM449_RS04050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM449_RS04075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BM449_RS04090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BM449_RS04095	COG1121	(ABC) transporter
BM449_RS04105	COG1012	belongs to the aldehyde dehydrogenase family
BM449_RS04115	COG0514	ATP-dependent DNA helicase (RecQ)
BM449_RS04125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BM449_RS04130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BM449_RS04135	COG0366	Alpha amylase catalytic
BM449_RS04145	COG0395	ABC-type sugar transport system, permease component
BM449_RS04155	COG1653	transport
BM449_RS04160	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BM449_RS04195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BM449_RS04200	COG0235	Class ii aldolase
BM449_RS04205	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BM449_RS04235	COG0483	inositol monophosphate 1-phosphatase activity
BM449_RS04255	COG1968	undecaprenyl-diphosphatase activity
BM449_RS04265	COG1555	photosystem II stabilization
BM449_RS04270	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BM449_RS04275	COG4243	Vitamin k epoxide reductase
BM449_RS04280	COG0434	BtpA family
BM449_RS04285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BM449_RS04295	COG1032	radical SAM domain protein
BM449_RS04325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BM449_RS04345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BM449_RS04350	COG1472	Belongs to the glycosyl hydrolase 3 family
BM449_RS04360	COG0463	Glycosyl transferase, family 2
BM449_RS04360	COG0457	Tetratricopeptide repeat
BM449_RS04365	COG1587	Uroporphyrinogen-III synthase
BM449_RS04380	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BM449_RS04385	COG0316	Belongs to the HesB IscA family
BM449_RS04405	COG1090	epimerase
BM449_RS04410	COG3263	regulation of cellular component size
BM449_RS04420	COG0484	heat shock protein binding
BM449_RS04425	COG3659	wide pore channel activity
BM449_RS04430	COG3659	wide pore channel activity
BM449_RS04460	COG1122	ATPase activity
BM449_RS04470	COG0745	RESPONSE REGULATOR receiver
BM449_RS04480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BM449_RS04485	COG2217	Heavy metal translocating P-type atpase
BM449_RS04490	COG0457	Tetratricopeptide repeat
BM449_RS04495	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BM449_RS04505	COG0416	fatty acid biosynthetic process
BM449_RS04510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BM449_RS04515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BM449_RS04530	COG1214	PFAM Peptidase M22, glycoprotease
BM449_RS04540	COG0617	tRNA 3'-terminal CCA addition
BM449_RS04545	COG0724	RNA recognition motif
BM449_RS04555	COG1562	ergosterol biosynthetic process
BM449_RS04560	COG0493	'glutamate synthase
BM449_RS04560	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BM449_RS04575	COG0583	DNA-binding transcription factor activity
BM449_RS04585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BM449_RS04590	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_RS04605	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BM449_RS04615	COG2197	response regulator
BM449_RS04625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BM449_RS04630	COG0713	ATP synthesis coupled electron transport
BM449_RS04635	COG0839	Belongs to the complex I subunit 6 family
BM449_RS04640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_RS04645	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BM449_RS04650	COG0372	Belongs to the citrate synthase family
BM449_RS04655	COG2062	phosphohistidine phosphatase, SixA
BM449_RS04670	COG1420	regulation of RNA biosynthetic process
BM449_RS04680	COG0133	tryptophan synthase activity
BM449_RS04685	COG0023	Translation Initiation Factor
BM449_RS04695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BM449_RS04705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM449_RS04710	COG0564	pseudouridine synthase activity
BM449_RS04715	COG0745	RESPONSE REGULATOR receiver
BM449_RS04725	COG1104	cysteine desulfurase activity
BM449_RS04775	COG0824	Thioesterase
BM449_RS04780	COG1803	Methylglyoxal synthase
BM449_RS04780	COG1597	lipid kinase activity
BM449_RS04790	COG0521	Mo-molybdopterin cofactor biosynthetic process
BM449_RS04805	COG1215	transferase activity, transferring glycosyl groups
BM449_RS04820	COG0071	Belongs to the small heat shock protein (HSP20) family
BM449_RS04825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BM449_RS04830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM449_RS04855	COG0347	Belongs to the P(II) protein family
BM449_RS04870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM449_RS04870	COG0426	domain, Protein
BM449_RS04875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM449_RS04875	COG0426	domain, Protein
BM449_RS04880	COG1741	Belongs to the pirin family
BM449_RS04905	COG0509	glycine decarboxylation via glycine cleavage system
BM449_RS04910	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BM449_RS04930	COG0359	binds to the 23S rRNA
BM449_RS04935	COG1372	Participates in initiation and elongation during chromosome replication
BM449_RS04935	COG1372	Participates in initiation and elongation during chromosome replication
BM449_RS04935	COG0305	Participates in initiation and elongation during chromosome replication
BM449_RS04935	COG0305	Participates in initiation and elongation during chromosome replication
BM449_RS04945	COG0445	tRNA wobble uridine modification
BM449_RS04970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM449_RS04980	COG0398	Pfam SNARE associated Golgi protein
BM449_RS04995	COG3550	peptidyl-serine autophosphorylation
BM449_RS05005	COG3119	arylsulfatase activity
BM449_RS05010	COG0525	valine-tRNA ligase activity
BM449_RS05025	COG3220	belongs to the UPF0276 family
BM449_RS05060	COG0523	cobalamin synthesis protein
BM449_RS05095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BM449_RS05100	COG1121	(ABC) transporter
BM449_RS05120	COG0523	cobalamin synthesis protein
BM449_RS05140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BM449_RS05160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM449_RS05165	COG0678	peroxiredoxin activity
BM449_RS05185	COG0438	transferase activity, transferring glycosyl groups
BM449_RS05220	COG0659	secondary active sulfate transmembrane transporter activity
BM449_RS05230	COG0745	RESPONSE REGULATOR receiver
BM449_RS05245	COG3237	CsbD-like
BM449_RS05255	COG3237	CsbD-like
BM449_RS05270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BM449_RS05275	COG2813	Specifically methylates the guanine in position
BM449_RS05280	COG1012	belongs to the aldehyde dehydrogenase family
BM449_RS05295	COG3237	CsbD-like
BM449_RS05310	COG3237	CsbD-like
BM449_RS05330	COG3237	CsbD-like
BM449_RS05335	COG4251	negative regulation of phosphorylation
BM449_RS05340	COG0784	Response regulator, receiver
BM449_RS05345	COG0784	Response regulator, receiver
BM449_RS05345	COG2205	protein histidine kinase activity
BM449_RS05355	COG3220	belongs to the UPF0276 family
BM449_RS05375	COG3956	TIGRFAM MazG family protein
BM449_RS05380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BM449_RS05385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BM449_RS05390	COG0010	Belongs to the arginase family
BM449_RS05405	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BM449_RS05410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BM449_RS05415	COG0783	Belongs to the Dps family
BM449_RS05420	COG0504	CTP synthase activity
BM449_RS05425	COG0602	queuosine metabolic process
BM449_RS05435	COG0124	histidyl-tRNA synthetase
BM449_RS05440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BM449_RS05470	COG4447	cellulose binding
BM449_RS05475	COG1773	rubredoxin
BM449_RS05480	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_RS05485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_RS05490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_RS05495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BM449_RS05500	COG3842	ATPase activity
BM449_RS05510	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BM449_RS05510	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BM449_RS05525	COG3631	Ketosteroid isomerase-related protein
BM449_RS05565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM449_RS05635	COG0556	nucleotide-excision repair
BM449_RS05815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BM449_RS05820	COG0494	nUDIX hydrolase
BM449_RS05825	COG0415	Belongs to the DNA photolyase family
BM449_RS05850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BM449_RS05860	COG0131	Imidazoleglycerol-phosphate dehydratase
BM449_RS05865	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
BM449_RS05890	COG0668	transmembrane transport
BM449_RS05935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BM449_RS05940	COG3119	arylsulfatase activity
BM449_RS05955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BM449_RS05960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM449_RS05970	COG0354	folic acid binding
BM449_RS05975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BM449_RS06000	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BM449_RS06010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BM449_RS06015	COG0390	transport system, permease component
BM449_RS06030	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BM449_RS06050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM449_RS06070	COG0351	phosphomethylpyrimidine kinase
BM449_RS06075	COG0366	Alpha amylase catalytic
BM449_RS06080	COG0366	Alpha amylase catalytic
BM449_RS06095	COG2217	Heavy metal translocating P-type atpase
BM449_RS06115	COG1215	transferase activity, transferring glycosyl groups
BM449_RS06135	COG2226	methyltransferase
BM449_RS06140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM449_RS06155	COG1191	sigma factor activity
BM449_RS06170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM449_RS06175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM449_RS06185	COG0243	molybdopterin cofactor binding
BM449_RS06190	COG2223	nitrite transmembrane transporter activity
BM449_RS06195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BM449_RS06195	COG1017	nitric oxide dioxygenase activity
BM449_RS06205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BM449_RS06220	COG0237	dephospho-CoA kinase activity
BM449_RS06225	COG4782	Protein conserved in bacteria
BM449_RS06230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BM449_RS06235	COG2022	thiamine diphosphate biosynthetic process
BM449_RS06235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM449_RS06240	COG0105	UTP biosynthetic process
BM449_RS06245	COG1166	arginine decarboxylase activity
BM449_RS06250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM449_RS06250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM449_RS06260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BM449_RS06270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BM449_RS06280	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BM449_RS06295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM449_RS06335	COG3657	addiction module killer protein
BM449_RS06340	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM449_RS06380	COG0148	phosphopyruvate hydratase activity
BM449_RS06385	COG0346	lactoylglutathione lyase activity
BM449_RS06390	COG0542	response to heat
BM449_RS06395	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM449_RS06400	COG0250	Participates in transcription elongation, termination and antitermination
BM449_RS06405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BM449_RS06410	COG0081	regulation of translation
BM449_RS06415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BM449_RS06420	COG0222	ribosome binding
BM449_RS06435	COG0167	dihydroorotate dehydrogenase activity
BM449_RS06455	COG1450	Type ii and iii secretion system protein
BM449_RS06465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM449_RS06470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BM449_RS06480	COG2084	Dehydrogenase
BM449_RS06490	COG0126	phosphoglycerate kinase activity
BM449_RS06495	COG0589	response to stress
BM449_RS06500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BM449_RS06505	COG0564	pseudouridine synthase activity
BM449_RS06510	COG0038	chloride channel
BM449_RS06515	COG4172	Belongs to the ABC transporter superfamily
BM449_RS06520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM449_RS06525	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BM449_RS06540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BM449_RS06545	COG0157	Belongs to the NadC ModD family
BM449_RS06560	COG0641	radical SAM
BM449_RS06565	COG0018	arginyl-trna synthetase
BM449_RS06570	COG2351	hydroxyisourate hydrolase activity
BM449_RS06610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM449_RS06615	COG1752	Esterase of the alpha-beta hydrolase superfamily
BM449_RS06625	COG5487	UPF0391 membrane protein
BM449_RS06630	COG0668	transmembrane transport
BM449_RS06645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM449_RS06680	COG0512	Glutamine amidotransferase of anthranilate synthase
BM449_RS06685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BM449_RS06690	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BM449_RS06700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BM449_RS06705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM449_RS06710	COG0189	ligase activity
BM449_RS06720	COG1575	Belongs to the MenA family. Type 1 subfamily
BM449_RS06735	COG2226	methyltransferase
BM449_RS06745	COG0314	molybdopterin synthase activity
BM449_RS06750	COG0303	'Molybdopterin
BM449_RS06755	COG0315	cyclic pyranopterin monophosphate synthase activity
BM449_RS06765	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BM449_RS06770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_RS06775	COG0170	dolichyl monophosphate biosynthetic process
BM449_RS06785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BM449_RS06790	COG1049	propionate catabolic process, 2-methylcitrate cycle
BM449_RS06795	COG0038	chloride channel
BM449_RS06815	COG0788	formyltetrahydrofolate deformylase activity
BM449_RS06830	COG0443	Heat shock 70 kDa protein
BM449_RS06835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BM449_RS06845	COG0360	Binds together with S18 to 16S ribosomal RNA
BM449_RS06850	COG0137	argininosuccinate synthase activity
BM449_RS06865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BM449_RS06880	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BM449_RS06900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BM449_RS06905	COG0497	DNA recombination
BM449_RS06910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM449_RS06920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BM449_RS06925	COG0592	DNA-directed DNA polymerase activity
BM449_RS06935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BM449_RS06940	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BM449_RS06945	COG2818	Glycosylase
BM449_RS06950	COG3415	Transposase
BM449_RS06950	COG2801	Transposase and inactivated derivatives
BM449_RS06960	COG0277	FAD linked oxidase domain protein
BM449_RS06985	COG0475	glutathione-regulated potassium exporter activity
BM449_RS06995	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BM449_RS07000	COG0058	SHG alpha-glucan phosphorylase activity
BM449_RS07005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BM449_RS07030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BM449_RS07060	COG1487	ribonuclease activity
BM449_RS07085	COG0571	ribonuclease III activity
BM449_RS07105	COG0709	Synthesizes selenophosphate from selenide and ATP
BM449_RS07110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM449_RS07120	COG0058	SHG alpha-glucan phosphorylase activity
BM449_RS07135	COG2308	Evidence 4 Homologs of previously reported genes of
BM449_RS07140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BM449_RS07150	COG2116	formate transmembrane transporter activity
BM449_RS07155	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BM449_RS07165	COG0832	Belongs to the urease beta subunit family
BM449_RS07170	COG0831	urea catabolic process
BM449_RS07180	COG2211	Major facilitator Superfamily
BM449_RS07195	COG0829	nickel cation binding
BM449_RS07200	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BM449_RS07205	COG0830	nickel cation binding
BM449_RS07210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BM449_RS07255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BM449_RS07260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM449_RS07265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BM449_RS07270	COG0515	serine threonine protein kinase
BM449_RS07280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BM449_RS07310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BM449_RS07315	COG0745	RESPONSE REGULATOR receiver
BM449_RS07320	COG1653	transport
BM449_RS07340	COG0629	single-stranded DNA binding
BM449_RS07345	COG0586	Pfam SNARE associated Golgi protein
BM449_RS07350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BM449_RS07355	COG0802	atpase or kinase
BM449_RS07360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM449_RS07380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_RS07385	COG2239	Acts as a magnesium transporter
BM449_RS07390	COG0386	Belongs to the glutathione peroxidase family
BM449_RS07395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BM449_RS07400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BM449_RS07410	COG0187	DNA topoisomerase II activity
BM449_RS07410	COG1372	Participates in initiation and elongation during chromosome replication
BM449_RS07415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BM449_RS07420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BM449_RS07425	COG1725	Transcriptional regulator
BM449_RS07430	COG1045	serine acetyltransferase
BM449_RS07435	COG0653	protein targeting
BM449_RS07460	COG0438	transferase activity, transferring glycosyl groups
BM449_RS07470	COG0438	transferase activity, transferring glycosyl groups
BM449_RS07475	COG0438	transferase activity, transferring glycosyl groups
BM449_RS07520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BM449_RS07540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BM449_RS07545	COG2082	Precorrin-8x methylmutase
BM449_RS07560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM449_RS07565	COG0556	nucleotide-excision repair
BM449_RS07580	COG0037	tRNA processing
BM449_RS07590	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BM449_RS07595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BM449_RS07600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BM449_RS07605	COG0544	peptidyl-prolyl cis-trans isomerase activity
BM449_RS07610	COG0740	serine-type endopeptidase activity
BM449_RS07615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BM449_RS07625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BM449_RS07630	COG1215	transferase activity, transferring glycosyl groups
BM449_RS07635	COG2385	sporulation resulting in formation of a cellular spore
BM449_RS07640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BM449_RS07645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BM449_RS07660	COG2022	thiamine diphosphate biosynthetic process
BM449_RS07670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM449_RS07695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BM449_RS07695	COG0519	Catalyzes the synthesis of GMP from XMP
BM449_RS07700	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BM449_RS07770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BM449_RS07775	COG0511	ligase activity, forming carbon-carbon bonds
BM449_RS07780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BM449_RS07790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BM449_RS07795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BM449_RS07800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM449_RS07805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BM449_RS07810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BM449_RS07815	COG1162	GTPase activity
BM449_RS07825	COG0484	heat shock protein binding
BM449_RS07830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BM449_RS07845	COG1459	type II secretion system
BM449_RS07850	COG2081	HI0933 family
BM449_RS07855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM449_RS07860	COG0724	RNA recognition motif
BM449_RS07865	COG0165	Argininosuccinate lyase
BM449_RS07870	COG2208	phosphoserine phosphatase activity
BM449_RS07875	COG0552	protein localization to endoplasmic reticulum
BM449_RS07880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BM449_RS07895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BM449_RS07905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BM449_RS07910	COG0247	lactate metabolic process
BM449_RS07915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BM449_RS07915	COG2755	lipolytic protein G-D-S-L family
BM449_RS07920	COG0538	isocitrate dehydrogenase activity
BM449_RS07930	COG5398	heme oxygenase
BM449_RS07940	COG1132	(ABC) transporter
BM449_RS07945	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BM449_RS07950	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BM449_RS07995	COG0438	transferase activity, transferring glycosyl groups
BM449_RS08000	COG0438	transferase activity, transferring glycosyl groups
BM449_RS08015	COG0438	transferase activity, transferring glycosyl groups
BM449_RS08030	COG0617	tRNA 3'-terminal CCA addition
BM449_RS08035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BM449_RS08045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BM449_RS08060	COG1473	amidohydrolase
BM449_RS08075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BM449_RS08100	COG0583	DNA-binding transcription factor activity
BM449_RS08105	COG0463	Glycosyl transferase, family 2
BM449_RS08110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BM449_RS08115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM449_RS08120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BM449_RS08125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_RS08130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM449_RS08135	COG1253	flavin adenine dinucleotide binding
BM449_RS08160	COG0343	queuine tRNA-ribosyltransferase activity
BM449_RS08165	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BM449_RS08170	COG2205	protein histidine kinase activity
BM449_RS08185	COG0138	bifunctional purine biosynthesis protein purh
BM449_RS08200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BM449_RS08205	COG0004	ammonium transporteR
BM449_RS08210	COG1489	DNA binding
BM449_RS08215	COG0728	peptidoglycan biosynthetic process
BM449_RS08240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BM449_RS08245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BM449_RS08250	COG1058	Belongs to the CinA family
BM449_RS08250	COG1546	Belongs to the CinA family
BM449_RS08255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BM449_RS08260	COG0066	3-isopropylmalate dehydratase activity
BM449_RS08295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BM449_RS08300	COG0193	aminoacyl-tRNA hydrolase activity
BM449_RS08315	COG4372	Transposase
BM449_RS08320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM449_RS08325	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BM449_RS08330	COG0717	Belongs to the dCTP deaminase family
BM449_RS08340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BM449_RS08355	COG1196	nuclear chromosome segregation
BM449_RS08355	COG0741	lytic transglycosylase activity
BM449_RS08355	COG0739	heme binding
BM449_RS08365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM449_RS08380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BM449_RS08405	COG0484	heat shock protein binding
BM449_RS08410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BM449_RS08440	COG0076	glutamate decarboxylase activity
BM449_RS08480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM449_RS08485	COG0745	RESPONSE REGULATOR receiver
BM449_RS08490	COG5002	protein histidine kinase activity
BM449_RS08500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BM449_RS08515	COG0725	ABC transporter, periplasmic molybdate-binding protein
BM449_RS08525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BM449_RS08535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BM449_RS08540	COG1402	creatininase
BM449_RS08550	COG0540	Belongs to the ATCase OTCase family
BM449_RS08575	COG3536	Protein conserved in bacteria
BM449_RS08580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BM449_RS08590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM449_RS08620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BM449_RS08630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BM449_RS08640	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BM449_RS08645	COG0436	Aminotransferase
BM449_RS08650	COG1530	ribonuclease E activity
BM449_RS08655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BM449_RS08670	COG2226	methyltransferase
BM449_RS08680	COG0051	transcription antitermination factor activity, RNA binding
BM449_RS08685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BM449_RS08690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BM449_RS08695	COG0049	tRNA binding
BM449_RS08715	COG0070	glutamate synthase
BM449_RS08715	COG0067	glutamate synthase
BM449_RS08715	COG0069	glutamate synthase activity
BM449_RS08720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BM449_RS08740	COG2885	chlorophyll binding
BM449_RS08745	COG2885	chlorophyll binding
BM449_RS08770	COG0463	Glycosyl transferase, family 2
BM449_RS08790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BM449_RS08800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BM449_RS08805	COG0254	rRNA binding
BM449_RS08810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BM449_RS08820	COG0101	tRNA pseudouridine synthase activity
BM449_RS08830	COG0202	RNA polymerase activity
BM449_RS08840	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BM449_RS08845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BM449_RS08850	COG0563	adenylate kinase activity
BM449_RS08855	COG0201	protein transport
BM449_RS08860	COG0200	Binds to the 23S rRNA
BM449_RS08865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BM449_RS08875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BM449_RS08885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BM449_RS08890	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BM449_RS08895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BM449_RS08900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BM449_RS08905	COG0255	Belongs to the universal ribosomal protein uL29 family
BM449_RS08910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BM449_RS08915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BM449_RS08920	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BM449_RS08925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BM449_RS08930	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BM449_RS08935	COG0089	rRNA binding
BM449_RS08940	COG0088	Forms part of the polypeptide exit tunnel
BM449_RS08945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BM449_RS08960	COG3854	ATPases associated with a variety of cellular activities
BM449_RS08975	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BM449_RS09005	COG3001	Fructosamine kinase
BM449_RS09025	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BM449_RS09030	COG1606	tRNA processing
BM449_RS09035	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BM449_RS09040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BM449_RS09055	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BM449_RS09060	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BM449_RS09065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM449_RS09080	COG0772	Belongs to the SEDS family
BM449_RS09085	COG0489	protein tyrosine kinase activity
BM449_RS09090	COG0408	coproporphyrinogen oxidase activity
BM449_RS09140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BM449_RS09145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM449_RS09150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BM449_RS09150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BM449_RS09155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BM449_RS09160	COG1413	lyase activity
BM449_RS09195	COG0237	dephospho-CoA kinase activity
BM449_RS09285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BM449_RS09315	COG1070	Carbohydrate kinase
BM449_RS09320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BM449_RS09325	COG0546	phosphoglycolate phosphatase activity
BM449_RS09330	COG0539	negative regulation of cytoplasmic translation
BM449_RS09375	COG2890	protein-(glutamine-N5) methyltransferase activity
BM449_RS09380	COG0009	L-threonylcarbamoyladenylate synthase
BM449_RS09410	COG0651	ATP synthesis coupled electron transport
BM449_RS09415	COG1006	Multisubunit Na H antiporter MnhC subunit
BM449_RS09430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BM449_RS09435	COG2894	cell division
BM449_RS09440	COG0850	regulation of cytokinetic process
BM449_RS09445	COG1078	dGTPase activity
BM449_RS09450	COG0793	Belongs to the peptidase S41A family
BM449_RS09455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BM449_RS09460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BM449_RS09515	COG1570	exodeoxyribonuclease VII activity
BM449_RS09525	COG1643	Atp-dependent helicase
BM449_RS09540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM449_RS09550	COG0488	(ABC) transporter
BM449_RS09575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BM449_RS09580	COG0569	domain protein
BM449_RS09585	COG0450	alkyl hydroperoxide reductase
BM449_RS09590	COG3273	potassium ion transport
BM449_RS09590	COG0471	metal ion transport
BM449_RS09595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BM449_RS09600	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BM449_RS09605	COG1252	NADH dehydrogenase
BM449_RS09610	COG0175	sulfate reduction
BM449_RS09615	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BM449_RS09620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BM449_RS09645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM449_RS09665	COG0033	Phosphoglucomutase
BM449_RS09705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BM449_RS09730	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
BM449_RS09735	COG0719	Fe-S assembly protein
BM449_RS09740	COG0396	ATPase activity
BM449_RS09745	COG0719	Fe-S assembly protein
BM449_RS09750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BM449_RS09770	COG1598	PFAM Uncharacterised protein family UPF0150
BM449_RS09785	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BM449_RS09790	COG3347	Dehydrogenase
BM449_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
BM449_RS09805	COG0242	peptide deformylase activity
BM449_RS09820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BM449_RS09825	COG0606	chelatase, subunit chli
BM449_RS09830	COG0537	adenosine 5'-monophosphoramidase activity
BM449_RS09835	COG4178	(ABC) transporter
BM449_RS09845	COG0515	serine threonine protein kinase
BM449_RS09860	COG0439	Biotin carboxylase
BM449_RS09875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM449_RS09885	COG1196	nuclear chromosome segregation
BM449_RS09900	COG0116	Belongs to the methyltransferase superfamily
BM449_RS09925	COG4243	Vitamin k epoxide reductase
BM449_RS09930	COG0484	heat shock protein binding
BM449_RS09935	COG0113	porphobilinogen synthase activity
BM449_RS09945	COG1193	negative regulation of DNA recombination
BM449_RS09950	COG3842	ATPase activity
BM449_RS09955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BM449_RS09965	COG0488	(ABC) transporter
BM449_RS09975	COG0435	Glutathione S-transferase
BM449_RS09980	COG2988	succinylglutamate desuccinylase activity
BM449_RS10000	COG4106	trans-aconitate 2-methyltransferase activity
BM449_RS10040	COG3266	domain, Protein
BM449_RS10040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BM449_RS10050	COG0195	Participates in both transcription termination and antitermination
BM449_RS10055	COG0779	Required for maturation of 30S ribosomal subunits
BM449_RS10065	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BM449_RS10070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM449_RS10075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BM449_RS10080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BM449_RS10085	COG0268	Binds directly to 16S ribosomal RNA
BM449_RS10090	COG0084	hydrolase, TatD family'
BM449_RS10095	COG0085	RNA polymerase activity
BM449_RS10100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BM449_RS10105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BM449_RS10115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BM449_RS10125	COG2223	nitrite transmembrane transporter activity
BM449_RS10155	COG0357	Ribosomal RNA small subunit methyltransferase G
BM449_RS10160	COG0484	heat shock protein binding
BM449_RS10170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BM449_RS10175	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BM449_RS10195	COG4581	dead DEAH box helicase
BM449_RS10200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BM449_RS10225	COG1799	cell septum assembly
BM449_RS10235	COG0724	RNA recognition motif
BM449_RS10240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BM449_RS10255	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BM449_RS10260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BM449_RS10275	COG1022	Amp-dependent synthetase and ligase
BM449_RS10280	COG0321	lipoyl(octanoyl) transferase activity
BM449_RS10285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BM449_RS10290	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BM449_RS10295	COG1381	Involved in DNA repair and RecF pathway recombination
BM449_RS10305	COG0438	transferase activity, transferring glycosyl groups
BM449_RS10320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BM449_RS10325	COG1231	oxidoreductase activity
BM449_RS10330	COG0284	orotidine-5'-phosphate decarboxylase activity
BM449_RS10335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BM449_RS10355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM449_RS10370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM449_RS10380	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM449_RS10385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM449_RS10390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BM449_RS10410	COG0151	Belongs to the GarS family
BM449_RS10415	COG5002	protein histidine kinase activity
BM449_RS10420	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BM449_RS10435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BM449_RS10445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM449_RS10450	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BM449_RS10455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BM449_RS10460	COG0217	transcriptional regulatory protein
BM449_RS10465	COG0363	glucosamine-6-phosphate deaminase activity
BM449_RS10470	COG2385	sporulation resulting in formation of a cellular spore
BM449_RS10470	COG2247	cell wall binding repeat
BM449_RS10475	COG1234	tRNA 3'-trailer cleavage
BM449_RS10480	COG2010	Cytochrome c
BM449_RS10495	COG2264	protein methyltransferase activity
BM449_RS10500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM449_RS10510	COG2302	S4 RNA-binding domain
BM449_RS10520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BM449_RS10550	COG0443	Heat shock 70 kDa protein
BM449_RS10565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BM449_RS10585	COG0459	protein refolding
BM449_RS10590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BM449_RS10595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BM449_RS10600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BM449_RS10615	COG0006	proline dipeptidase activity
BM449_RS10620	COG1253	flavin adenine dinucleotide binding
BM449_RS10625	COG1160	GTP binding
BM449_RS10630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BM449_RS10635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BM449_RS10635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM449_RS10640	COG0686	Belongs to the AlaDH PNT family
BM449_RS10645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM449_RS10655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BM449_RS10665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BM449_RS10670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BM449_RS10675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BM449_RS10680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BM449_RS10685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BM449_RS10690	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BM449_RS10695	COG0356	it plays a direct role in the translocation of protons across the membrane
BM449_RS10705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM449_RS10710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BM449_RS10730	COG0772	Belongs to the SEDS family
BM449_RS10740	COG1333	cytochrome c biogenesis protein
BM449_RS10745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM449_RS10760	COG0347	Belongs to the P(II) protein family
BM449_RS10770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BM449_RS10840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM449_RS10845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BM449_RS10855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BM449_RS10860	COG2176	DNA-directed DNA polymerase activity
BM449_RS10865	COG0598	Magnesium transport protein CorA
BM449_RS10880	COG1732	Glycine betaine
BM449_RS10905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM449_RS10915	COG1132	(ABC) transporter
BM449_RS10925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM449_RS10930	COG0505	Belongs to the CarA family
BM449_RS10940	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BM449_RS10945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM449_RS10955	COG0154	amidase activity
BM449_RS10960	COG0859	PFAM glycosyl transferase family 9
BM449_RS10960	COG0457	Tetratricopeptide repeat
BM449_RS10965	COG0587	DNA-directed DNA polymerase activity
BM449_RS11000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BM449_RS11005	COG0632	four-way junction helicase activity
BM449_RS11015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM449_RS11020	COG0842	Transport permease protein
BM449_RS11020	COG1129	ABC transporter
BM449_RS11025	COG0842	Transport permease protein
BM449_RS11065	COG0358	DNA primase activity
BM449_RS11080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BM449_RS11100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BM449_RS11110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BM449_RS11120	COG0022	dehydrogenase e1 component
BM449_RS11120	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM449_RS11125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM449_RS11130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM449_RS11145	COG0628	permease
BM449_RS11155	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BM449_RS11160	COG0515	serine threonine protein kinase
BM449_RS11180	COG2226	methyltransferase
BM449_RS11185	COG0174	glutamine synthetase
BM449_RS11195	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM449_RS11215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BM449_RS11220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BM449_RS11240	COG0612	Peptidase, M16
BM449_RS11250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM449_RS11260	COG1136	(ABC) transporter
BM449_RS11265	COG1216	Glycosyl transferase, family 2
BM449_RS11270	COG0052	Belongs to the universal ribosomal protein uS2 family
BM449_RS11275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BM449_RS11285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BM449_RS11290	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BM449_RS11300	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BM449_RS11305	COG0751	glycine-tRNA ligase activity
BM449_RS11310	COG0644	oxidoreductase
BM449_RS11320	COG1217	gtp-binding protein TYPA
BM449_RS11345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM449_RS11350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BM449_RS11355	COG1494	fructose-1,6-bisphosphatase
BM449_RS11360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BM449_RS11365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BM449_RS11370	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BM449_RS11375	COG0363	glucosamine-6-phosphate deaminase activity
BM449_RS11390	COG0129	dihydroxy-acid dehydratase activity
BM449_RS11405	COG1845	cytochrome c oxidase, subunit III
BM449_RS11410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BM449_RS11435	COG0405	Gamma-glutamyltransferase
BM449_RS11445	COG1666	GTP binding
BM449_RS11455	COG0330	HflC and HflK could
BM449_RS11470	COG0857	belongs to the CobB CobQ family
BM449_RS11475	COG3000	fatty acid hydroxylase
BM449_RS11475	COG0300	oxidoreductase activity
BM449_RS11480	COG0024	Methionine aminopeptidase
BM449_RS11490	COG0335	large ribosomal subunit rRNA binding
BM449_RS11515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM449_RS11525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM449_RS11525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM449_RS11555	COG0489	protein tyrosine kinase activity
BM449_RS11590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BM449_RS11635	COG0438	transferase activity, transferring glycosyl groups
BM449_RS11650	COG0463	Glycosyl transferase, family 2
BM449_RS11660	COG0438	transferase activity, transferring glycosyl groups
BM449_RS11680	COG0438	transferase activity, transferring glycosyl groups
BM449_RS11700	COG0463	Glycosyl transferase, family 2
BM449_RS11710	COG1215	transferase activity, transferring glycosyl groups
BM449_RS11735	COG2801	Transposase and inactivated derivatives
BM449_RS11750	COG0438	transferase activity, transferring glycosyl groups
BM449_RS11760	COG1215	transferase activity, transferring glycosyl groups
BM449_RS11820	COG1132	(ABC) transporter
BM449_RS11925	COG0215	cysteine-tRNA ligase activity
BM449_RS11935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BM449_RS11940	COG3411	Ferredoxin
BM449_RS11950	COG0702	epimerase
BM449_RS11965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BM449_RS11980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM449_RS11995	COG2267	carboxylic ester hydrolase activity
BM449_RS12000	COG0440	acetolactate synthase activity
BM449_RS12005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM449_RS12035	COG0424	maF-like protein
BM449_RS12045	COG1492	cobalamin metabolic process
BM449_RS12055	COG0482	sulfurtransferase activity
BM449_RS12060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BM449_RS12060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BM449_RS12065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_RS12070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BM449_RS12080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BM449_RS12090	COG1702	phosphate starvation-inducible protein PhoH
BM449_RS12095	COG0670	Belongs to the BI1 family
BM449_RS12100	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BM449_RS12105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM449_RS12115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BM449_RS12125	COG0336	Belongs to the RNA methyltransferase TrmD family
BM449_RS12130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BM449_RS12140	COG1691	(AIR) carboxylase
BM449_RS12160	COG0196	riboflavin kinase activity
BM449_RS12170	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BM449_RS12175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BM449_RS12180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BM449_RS12215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM449_RS12215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM449_RS12220	COG0668	transmembrane transport
BM449_RS12235	COG0628	permease
BM449_RS12245	COG3239	Fatty acid desaturase
BM449_RS12265	COG2826	transposase and inactivated derivatives, IS30 family
BM449_RS12290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM449_RS12295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BM449_RS12300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BM449_RS12315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BM449_RS12315	COG0574	Belongs to the PEP-utilizing enzyme family
BM449_RS12335	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
BM449_RS12340	COG3259	Nickel-dependent hydrogenase
BM449_RS12350	COG0375	protein maturation
BM449_RS12355	COG2345	Transcriptional regulator
BM449_RS12390	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BM449_RS12395	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BM449_RS12400	COG0298	carbon dioxide binding
BM449_RS12405	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BM449_RS12405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BM449_RS12405	COG1013	pyruvate-flavodoxin oxidoreductase activity
BM449_RS12405	COG0674	pyruvate-flavodoxin oxidoreductase activity
BM449_RS12425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM449_RS12430	COG0530	calcium, potassium:sodium antiporter activity
BM449_RS12435	COG0659	secondary active sulfate transmembrane transporter activity
BM449_RS12440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BM449_RS12445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BM449_RS12450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BM449_RS12465	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BM449_RS12470	COG0347	Belongs to the P(II) protein family
BM449_RS12475	COG1126	abc transporter atp-binding protein
BM449_RS12480	COG0765	amino acid transport
BM449_RS12485	COG4597	amino acid ABC transporter
BM449_RS12490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM449_RS12495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BM449_RS12500	COG0418	dihydroorotase activity
BM449_RS12505	COG0284	orotidine-5'-phosphate decarboxylase activity
BM449_RS12505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BM449_RS12510	COG2133	pyrroloquinoline quinone binding
BM449_RS12520	COG0010	Belongs to the arginase family
BM449_RS12525	COG0375	protein maturation
BM449_RS12540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BM449_RS12545	COG1116	anion transmembrane transporter activity
BM449_RS12560	COG2105	PFAM AIG2 family protein
BM449_RS12590	COG0811	peptide transport
BM449_RS12600	COG0644	oxidoreductase
BM449_RS12610	COG3424	synthase
BM449_RS12680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BM449_RS12700	COG0412	Dienelactone hydrolase
BM449_RS12730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BM449_RS12735	COG0514	ATP-dependent DNA helicase (RecQ)
BM449_RS12740	COG1175	transmembrane transport
BM449_RS12745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BM449_RS12760	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BM449_RS12780	COG0740	serine-type endopeptidase activity
BM449_RS12790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM449_RS12800	COG1136	(ABC) transporter
BM449_RS12800	COG0577	efflux transmembrane transporter activity
BM449_RS12805	COG0469	pyruvate kinase activity
BM449_RS12830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BM449_RS12835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BM449_RS12865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BM449_RS12870	COG0326	Molecular chaperone. Has ATPase activity
BM449_RS12875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BM449_RS12890	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BM449_RS12895	COG0483	inositol monophosphate 1-phosphatase activity
BM449_RS12910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BM449_RS12915	COG0581	inorganic phosphate transmembrane transporter activity
BM449_RS12920	COG0573	inorganic phosphate transmembrane transporter activity
BM449_RS12925	COG0443	Heat shock 70 kDa protein
BM449_RS12930	COG0484	heat shock protein binding
BM449_RS12940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BM449_RS12945	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BM449_RS12950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM449_RS12955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BM449_RS12955	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BM449_RS12960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BM449_RS12965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BM449_RS12990	COG0166	Belongs to the GPI family
BM449_RS12995	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BM449_RS13000	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BM449_RS13005	COG0495	leucyl-tRNA aminoacylation
BM449_RS13015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BM449_RS13035	COG2027	D-alanyl-D-alanine carboxypeptidase
BM449_RS13045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BM449_RS13050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM449_RS13050	COG0426	domain, Protein
BM449_RS13055	COG0322	excinuclease ABC activity
BM449_RS13060	COG1981	membrane
BM449_RS13080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BM449_RS13085	COG0646	methionine synthase
BM449_RS13085	COG1410	methionine synthase
BM449_RS13110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BM449_RS13115	COG0384	phenazine biosynthesis protein PhzF
BM449_RS13120	COG2385	sporulation resulting in formation of a cellular spore
BM449_RS13130	COG1191	sigma factor activity
BM449_RS13150	COG0248	Ppx GppA phosphatase
BM449_RS13155	COG2963	transposase activity
BM449_RS13160	COG2801	Transposase and inactivated derivatives
BM449_RS13170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BM449_RS13175	COG0072	phenylalanine-tRNA ligase activity
BM449_RS13175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM449_RS13180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BM449_RS13185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BM449_RS13190	COG0557	exoribonuclease II activity
BM449_RS13200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM449_RS13235	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BM449_RS13260	COG0450	alkyl hydroperoxide reductase
BM449_RS13265	COG0047	phosphoribosylformylglycinamidine synthase activity
BM449_RS13270	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BM449_RS13290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BM449_RS13295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BM449_RS13300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BM449_RS13305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BM449_RS13315	COG0297	glycogen (starch) synthase activity
BM449_RS13320	COG1376	ErfK ybiS ycfS ynhG family protein
BM449_RS13325	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BM449_RS13330	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BM449_RS13335	COG0681	Belongs to the peptidase S26 family
BM449_RS13375	COG0180	Tryptophanyl-tRNA synthetase
BM449_RS13390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BM449_RS13395	COG0837	glucose binding
BM449_RS13400	COG0083	homoserine kinase activity
BM449_RS13405	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_RS13410	COG0339	signal peptide processing
BM449_RS13420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM449_RS13425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BM449_RS13465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BM449_RS13470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BM449_RS13480	COG3794	PFAM blue (type 1) copper domain protein
BM449_RS13485	COG2010	Cytochrome c
BM449_RS13510	COG0542	response to heat
BM449_RS13520	COG0628	permease
BM449_RS13530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM449_RS13555	COG0159	tryptophan synthase activity
BM449_RS13565	COG1064	alcohol dehydrogenase
BM449_RS13570	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BM449_RS13585	COG2010	Cytochrome c
BM449_RS13625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_RS13640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BM449_RS13640	COG0140	phosphoribosyl-ATP diphosphatase activity
BM449_RS13650	COG0701	Predicted permease
BM449_RS13670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BM449_RS13675	COG1121	(ABC) transporter
BM449_RS13680	COG0803	Belongs to the bacterial solute-binding protein 9 family
BM449_RS13680	COG3443	Belongs to the bacterial solute-binding protein 9 family
BM449_RS13690	COG3128	pkhd-type hydroxylase
BM449_RS13700	COG3659	wide pore channel activity
BM449_RS13705	COG0310	cobalt ion transport
BM449_RS13710	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
BM449_RS13720	COG1122	ATPase activity
BM449_RS13730	COG0523	cobalamin synthesis protein
BM449_RS13740	COG1840	ABC-type Fe3 transport system, periplasmic component
BM449_RS13745	COG4176	ABC-type proline glycine betaine transport system permease component
BM449_RS13755	COG2801	Transposase and inactivated derivatives
BM449_RS13755	COG3415	Transposase
BM449_RS13780	COG0735	belongs to the Fur family
BM449_RS13790	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BM449_RS13815	COG0708	Exodeoxyribonuclease III
BM449_RS13820	COG0277	FAD linked oxidase domain protein
BM449_RS13825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BM449_RS13840	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BM449_RS13845	COG2045	Belongs to the ComB family
BM449_RS13860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BM449_RS13865	COG0142	geranyltranstransferase activity
BM449_RS13875	COG2226	methyltransferase
BM449_RS13915	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BM449_RS13935	COG0181	hydroxymethylbilane synthase activity
BM449_RS13950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BM449_RS13955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_RS13960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BM449_RS13970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BM449_RS13995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM449_RS14000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BM449_RS14010	COG0442	prolyl-tRNA aminoacylation
BM449_RS14035	COG0681	Belongs to the peptidase S26 family
BM449_RS14045	COG0406	alpha-ribazole phosphatase activity
BM449_RS14065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BM449_RS14075	COG0644	oxidoreductase
BM449_RS14080	COG0233	cytoplasmic translational termination
BM449_RS14100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BM449_RS14105	COG0028	Belongs to the TPP enzyme family
BM449_RS14130	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BM449_RS14150	COG0539	negative regulation of cytoplasmic translation
BM449_RS14160	COG3396	Phenylacetate-CoA oxygenase
BM449_RS14165	COG5322	oxidoreductase activity
BM449_RS14170	COG0825	malonyl-CoA metabolic process
BM449_RS14175	COG4221	oxidoreductase activity
BM449_RS14180	COG0302	gtp cyclohydrolase
BM449_RS14190	COG0135	phosphoribosylanthranilate isomerase activity
BM449_RS14195	COG1994	Peptidase M50
BM449_RS14195	COG0517	IMP dehydrogenase activity
BM449_RS14200	COG0095	Lipoate-protein ligase
BM449_RS14240	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BM449_RS14245	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BM449_RS14250	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BM449_RS14255	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BM449_RS14260	COG1850	ribulose-bisphosphate carboxylase activity
BM449_RS14265	COG4451	ribulose bisphosphate carboxylase, small
BM449_RS14290	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BM449_RS14305	COG0464	growth