locus-tag	class	description
SynWH8101_RS00005	COG0592	DNA-directed DNA polymerase activity
SynWH8101_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynWH8101_RS00020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynWH8101_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynWH8101_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynWH8101_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynWH8101_RS00055	COG0552	protein localization to endoplasmic reticulum
SynWH8101_RS00060	COG2208	phosphoserine phosphatase activity
SynWH8101_RS00065	COG0165	Argininosuccinate lyase
SynWH8101_RS00070	COG0724	RNA recognition motif
SynWH8101_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynWH8101_RS00080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynWH8101_RS00085	COG2081	HI0933 family
SynWH8101_RS00090	COG1459	type II secretion system
SynWH8101_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynWH8101_RS00105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynWH8101_RS00110	COG0484	heat shock protein binding
SynWH8101_RS00120	COG1162	GTPase activity
SynWH8101_RS00125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynWH8101_RS00130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynWH8101_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynWH8101_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynWH8101_RS00145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynWH8101_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynWH8101_RS00155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynWH8101_RS00160	COG0511	ligase activity, forming carbon-carbon bonds
SynWH8101_RS00165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynWH8101_RS00235	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynWH8101_RS00240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynWH8101_RS00240	COG0519	Catalyzes the synthesis of GMP from XMP
SynWH8101_RS00300	COG0768	penicillin binding
SynWH8101_RS00305	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_RS00305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynWH8101_RS00310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynWH8101_RS00320	COG2022	thiamine diphosphate biosynthetic process
SynWH8101_RS00335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynWH8101_RS00340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynWH8101_RS00345	COG2385	sporulation resulting in formation of a cellular spore
SynWH8101_RS00350	COG1215	transferase activity, transferring glycosyl groups
SynWH8101_RS00375	COG2801	Transposase and inactivated derivatives
SynWH8101_RS00375	COG3415	Transposase
SynWH8101_RS00385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynWH8101_RS00395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynWH8101_RS00400	COG0740	serine-type endopeptidase activity
SynWH8101_RS00405	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynWH8101_RS00410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynWH8101_RS00415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynWH8101_RS00420	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynWH8101_RS00430	COG0037	tRNA processing
SynWH8101_RS00445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynWH8101_RS00450	COG0556	nucleotide-excision repair
SynWH8101_RS00465	COG2082	Precorrin-8x methylmutase
SynWH8101_RS00475	COG2274	protein secretion by the type I secretion system
SynWH8101_RS00490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynWH8101_RS00505	COG0653	protein targeting
SynWH8101_RS00510	COG1045	serine acetyltransferase
SynWH8101_RS00515	COG1725	Transcriptional regulator
SynWH8101_RS00525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynWH8101_RS00530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynWH8101_RS00535	COG1372	Participates in initiation and elongation during chromosome replication
SynWH8101_RS00535	COG0187	DNA topoisomerase II activity
SynWH8101_RS00545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynWH8101_RS00550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynWH8101_RS00555	COG0386	Belongs to the glutathione peroxidase family
SynWH8101_RS00560	COG2239	Acts as a magnesium transporter
SynWH8101_RS00565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_RS00595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynWH8101_RS00600	COG1301	dicarboxylic acid transport
SynWH8101_RS00605	COG3961	Belongs to the TPP enzyme family
SynWH8101_RS00610	COG0402	S-adenosylhomocysteine deaminase activity
SynWH8101_RS00620	COG0523	cobalamin synthesis protein
SynWH8101_RS00625	COG0477	Major facilitator Superfamily
SynWH8101_RS00640	COG0802	atpase or kinase
SynWH8101_RS00645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynWH8101_RS00650	COG0586	Pfam SNARE associated Golgi protein
SynWH8101_RS00655	COG0629	single-stranded DNA binding
SynWH8101_RS00680	COG0745	RESPONSE REGULATOR receiver
SynWH8101_RS00685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynWH8101_RS00705	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynWH8101_RS00710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynWH8101_RS00715	COG0515	serine threonine protein kinase
SynWH8101_RS00720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynWH8101_RS00725	COG2255	four-way junction helicase activity
SynWH8101_RS00735	COG1473	amidohydrolase
SynWH8101_RS00750	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynWH8101_RS00760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynWH8101_RS00765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynWH8101_RS00770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynWH8101_RS00775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_RS00780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynWH8101_RS00790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynWH8101_RS00800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynWH8101_RS00805	COG0571	ribonuclease III activity
SynWH8101_RS00835	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynWH8101_RS00840	COG0058	SHG alpha-glucan phosphorylase activity
SynWH8101_RS00845	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SynWH8101_RS00850	COG0475	glutathione-regulated potassium exporter activity
SynWH8101_RS00870	COG0277	FAD linked oxidase domain protein
SynWH8101_RS00885	COG0247	lactate metabolic process
SynWH8101_RS00905	COG0538	isocitrate dehydrogenase activity
SynWH8101_RS00910	COG0463	Glycosyl transferase, family 2
SynWH8101_RS00925	COG5398	heme oxygenase
SynWH8101_RS00935	COG1132	(ABC) transporter
SynWH8101_RS00940	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_RS00945	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_RS00950	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_RS00955	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_RS00975	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynWH8101_RS00985	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynWH8101_RS00995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynWH8101_RS01015	COG0617	tRNA 3'-terminal CCA addition
SynWH8101_RS01015	COG0517	IMP dehydrogenase activity
SynWH8101_RS01015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynWH8101_RS01065	COG0709	Synthesizes selenophosphate from selenide and ATP
SynWH8101_RS01080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynWH8101_RS01095	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynWH8101_RS01100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynWH8101_RS01105	COG1132	(ABC) transporter
SynWH8101_RS01110	COG1086	Polysaccharide biosynthesis protein
SynWH8101_RS01120	COG1083	cytidylyl-transferase
SynWH8101_RS01125	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SynWH8101_RS01140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynWH8101_RS01145	COG2089	acid synthase
SynWH8101_RS01155	COG2801	Transposase and inactivated derivatives
SynWH8101_RS01170	COG3328	transposase activity
SynWH8101_RS01175	COG3328	transposase activity
SynWH8101_RS01190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynWH8101_RS01240	COG2337	Toxic component of a toxin-antitoxin (TA) module
SynWH8101_RS01305	COG0124	histidyl-tRNA synthetase
SynWH8101_RS01315	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynWH8101_RS01350	COG4447	cellulose binding
SynWH8101_RS01355	COG1773	rubredoxin
SynWH8101_RS01360	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_RS01365	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_RS01370	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_RS01380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynWH8101_RS01385	COG3842	ATPase activity
SynWH8101_RS01390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SynWH8101_RS01395	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynWH8101_RS01395	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynWH8101_RS01400	COG0494	nUDIX hydrolase
SynWH8101_RS01405	COG0415	Belongs to the DNA photolyase family
SynWH8101_RS01430	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynWH8101_RS01445	COG0131	Imidazoleglycerol-phosphate dehydratase
SynWH8101_RS01450	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynWH8101_RS01465	COG2271	Major facilitator Superfamily
SynWH8101_RS01470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynWH8101_RS01490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynWH8101_RS01495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynWH8101_RS01505	COG0354	folic acid binding
SynWH8101_RS01520	COG1253	flavin adenine dinucleotide binding
SynWH8101_RS01525	COG0673	inositol 2-dehydrogenase activity
SynWH8101_RS01545	COG0343	queuine tRNA-ribosyltransferase activity
SynWH8101_RS01570	COG0138	bifunctional purine biosynthesis protein purh
SynWH8101_RS01585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynWH8101_RS01590	COG0004	ammonium transporteR
SynWH8101_RS01595	COG1489	DNA binding
SynWH8101_RS01600	COG0728	peptidoglycan biosynthetic process
SynWH8101_RS01625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynWH8101_RS01630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynWH8101_RS01635	COG1058	Belongs to the CinA family
SynWH8101_RS01635	COG1546	Belongs to the CinA family
SynWH8101_RS01640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SynWH8101_RS01645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynWH8101_RS01650	COG0066	3-isopropylmalate dehydratase activity
SynWH8101_RS01685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynWH8101_RS01690	COG0193	aminoacyl-tRNA hydrolase activity
SynWH8101_RS01705	COG4372	Transposase
SynWH8101_RS01710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynWH8101_RS01715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynWH8101_RS01725	COG0717	Belongs to the dCTP deaminase family
SynWH8101_RS01730	COG3039	Transposase
SynWH8101_RS01745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynWH8101_RS01770	COG2971	BadF BadG BcrA BcrD
SynWH8101_RS01780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynWH8101_RS01800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynWH8101_RS01820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynWH8101_RS01825	COG1402	creatininase
SynWH8101_RS01830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynWH8101_RS01835	COG2094	Belongs to the DNA glycosylase MPG family
SynWH8101_RS01840	COG0540	Belongs to the ATCase OTCase family
SynWH8101_RS01875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynWH8101_RS01890	COG0529	Catalyzes the synthesis of activated sulfate
SynWH8101_RS01890	COG2046	Belongs to the sulfate adenylyltransferase family
SynWH8101_RS01895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH8101_RS01900	COG0800	Aldolase
SynWH8101_RS01910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynWH8101_RS01915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynWH8101_RS01920	COG2226	methyltransferase
SynWH8101_RS01925	COG4175	Glycine betaine
SynWH8101_RS01930	COG4176	ABC-type proline glycine betaine transport system permease component
SynWH8101_RS01935	COG2113	Glycine betaine
SynWH8101_RS01940	COG0463	Glycosyl transferase, family 2
SynWH8101_RS01945	COG0366	Alpha amylase catalytic
SynWH8101_RS01975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynWH8101_RS01980	COG0436	Aminotransferase
SynWH8101_RS01990	COG1530	ribonuclease E activity
SynWH8101_RS01995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynWH8101_RS02005	COG1605	Chorismate mutase
SynWH8101_RS02005	COG0077	Prephenate dehydratase
SynWH8101_RS02010	COG2226	methyltransferase
SynWH8101_RS02015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynWH8101_RS02020	COG0051	transcription antitermination factor activity, RNA binding
SynWH8101_RS02025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynWH8101_RS02030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynWH8101_RS02035	COG0049	tRNA binding
SynWH8101_RS02040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynWH8101_RS02055	COG0070	glutamate synthase
SynWH8101_RS02055	COG0069	glutamate synthase activity
SynWH8101_RS02055	COG0067	glutamate synthase
SynWH8101_RS02085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynWH8101_RS02105	COG2885	chlorophyll binding
SynWH8101_RS02110	COG2885	chlorophyll binding
SynWH8101_RS02145	COG0463	Glycosyl transferase, family 2
SynWH8101_RS02165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynWH8101_RS02175	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynWH8101_RS02180	COG0254	rRNA binding
SynWH8101_RS02185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynWH8101_RS02190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynWH8101_RS02200	COG0203	ribosomal protein L17
SynWH8101_RS02205	COG0202	RNA polymerase activity
SynWH8101_RS02210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynWH8101_RS02215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynWH8101_RS02220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynWH8101_RS02225	COG0563	adenylate kinase activity
SynWH8101_RS02230	COG0201	protein transport
SynWH8101_RS02235	COG0200	Binds to the 23S rRNA
SynWH8101_RS02240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynWH8101_RS02245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynWH8101_RS02250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynWH8101_RS02255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynWH8101_RS02260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynWH8101_RS02265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynWH8101_RS02270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynWH8101_RS02275	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynWH8101_RS02280	COG0255	Belongs to the universal ribosomal protein uL29 family
SynWH8101_RS02285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynWH8101_RS02290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynWH8101_RS02295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynWH8101_RS02300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynWH8101_RS02305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynWH8101_RS02310	COG0089	rRNA binding
SynWH8101_RS02315	COG0088	Forms part of the polypeptide exit tunnel
SynWH8101_RS02320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynWH8101_RS02335	COG3854	ATPases associated with a variety of cellular activities
SynWH8101_RS02350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynWH8101_RS02380	COG3001	Fructosamine kinase
SynWH8101_RS02400	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynWH8101_RS02405	COG1606	tRNA processing
SynWH8101_RS02410	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynWH8101_RS02415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynWH8101_RS02430	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynWH8101_RS02435	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynWH8101_RS02440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynWH8101_RS02455	COG0772	Belongs to the SEDS family
SynWH8101_RS02460	COG0489	protein tyrosine kinase activity
SynWH8101_RS02465	COG0408	coproporphyrinogen oxidase activity
SynWH8101_RS02525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynWH8101_RS02530	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynWH8101_RS02535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynWH8101_RS02535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynWH8101_RS02540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynWH8101_RS02685	COG2890	protein-(glutamine-N5) methyltransferase activity
SynWH8101_RS02715	COG1070	Carbohydrate kinase
SynWH8101_RS02720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynWH8101_RS02725	COG0546	phosphoglycolate phosphatase activity
SynWH8101_RS02730	COG0539	negative regulation of cytoplasmic translation
SynWH8101_RS02735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynWH8101_RS02760	COG0589	response to stress
SynWH8101_RS02770	COG0758	DNA mediated transformation
SynWH8101_RS02775	COG2890	protein-(glutamine-N5) methyltransferase activity
SynWH8101_RS02790	COG2197	response regulator
SynWH8101_RS02795	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynWH8101_RS02800	COG2894	cell division
SynWH8101_RS02805	COG0850	regulation of cytokinetic process
SynWH8101_RS02820	COG2059	Chromate
SynWH8101_RS02825	COG1078	dGTPase activity
SynWH8101_RS02830	COG0793	Belongs to the peptidase S41A family
SynWH8101_RS02835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynWH8101_RS02840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynWH8101_RS02875	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynWH8101_RS02880	COG0235	Class ii aldolase
SynWH8101_RS02885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynWH8101_RS02900	COG0514	ATP-dependent DNA helicase (RecQ)
SynWH8101_RS02905	COG1388	LysM domain
SynWH8101_RS02905	COG3942	CHAP domain
SynWH8101_RS02910	COG1012	belongs to the aldehyde dehydrogenase family
SynWH8101_RS02920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynWH8101_RS02940	COG0745	RESPONSE REGULATOR receiver
SynWH8101_RS02960	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynWH8101_RS02975	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynWH8101_RS03000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynWH8101_RS03015	COG1376	ErfK ybiS ycfS ynhG family protein
SynWH8101_RS03020	COG1160	GTP binding
SynWH8101_RS03025	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynWH8101_RS03035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynWH8101_RS03040	COG1799	cell septum assembly
SynWH8101_RS03045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynWH8101_RS03050	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_RS03060	COG1381	Involved in DNA repair and RecF pathway recombination
SynWH8101_RS03065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynWH8101_RS03070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynWH8101_RS03075	COG0321	lipoyl(octanoyl) transferase activity
SynWH8101_RS03080	COG1022	Amp-dependent synthetase and ligase
SynWH8101_RS03110	COG1475	DNA binding
SynWH8101_RS03120	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynWH8101_RS03140	COG0531	amino acid
SynWH8101_RS03145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynWH8101_RS03150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynWH8101_RS03165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynWH8101_RS03180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynWH8101_RS03195	COG0189	ligase activity
SynWH8101_RS03195	COG4067	protein conserved in archaea
SynWH8101_RS03205	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynWH8101_RS03210	COG0579	oxidoreductase
SynWH8101_RS03220	COG0481	GTPase activity
SynWH8101_RS03255	COG4969	Belongs to the N-Me-Phe pilin family
SynWH8101_RS03260	COG5002	protein histidine kinase activity
SynWH8101_RS03265	COG0745	RESPONSE REGULATOR receiver
SynWH8101_RS03290	COG2205	protein histidine kinase activity
SynWH8101_RS03305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynWH8101_RS03315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynWH8101_RS03315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynWH8101_RS03320	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynWH8101_RS03325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynWH8101_RS03335	COG0107	imidazoleglycerol-phosphate synthase activity
SynWH8101_RS03345	COG2226	methyltransferase
SynWH8101_RS03355	COG0752	glycyl-tRNA synthetase alpha subunit
SynWH8101_RS03395	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SynWH8101_RS03405	COG2217	Heavy metal translocating P-type atpase
SynWH8101_RS03435	COG0297	glycogen (starch) synthase activity
SynWH8101_RS03450	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynWH8101_RS03455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynWH8101_RS03460	COG0740	serine-type endopeptidase activity
SynWH8101_RS03465	COG0740	serine-type endopeptidase activity
SynWH8101_RS03470	COG4956	integral membrane protein (PIN domain superfamily)
SynWH8101_RS03480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynWH8101_RS03490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynWH8101_RS03505	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynWH8101_RS03510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynWH8101_RS03515	COG4948	Mandelate Racemase Muconate Lactonizing
SynWH8101_RS03550	COG0285	dihydrofolate synthase activity
SynWH8101_RS03555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynWH8101_RS03560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynWH8101_RS03565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynWH8101_RS03580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynWH8101_RS03585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynWH8101_RS03590	COG0134	indole-3-glycerol-phosphate synthase activity
SynWH8101_RS03600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynWH8101_RS03615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynWH8101_RS03620	COG0482	sulfurtransferase activity
SynWH8101_RS03625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynWH8101_RS03625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynWH8101_RS03630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_RS03635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynWH8101_RS03645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynWH8101_RS03655	COG1702	phosphate starvation-inducible protein PhoH
SynWH8101_RS03665	COG0477	Major facilitator Superfamily
SynWH8101_RS03680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynWH8101_RS03690	COG0336	Belongs to the RNA methyltransferase TrmD family
SynWH8101_RS03695	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynWH8101_RS03705	COG1691	(AIR) carboxylase
SynWH8101_RS03725	COG0352	thiamine-phosphate diphosphorylase activity
SynWH8101_RS03730	COG0196	riboflavin kinase activity
SynWH8101_RS03740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynWH8101_RS03745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynWH8101_RS03750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynWH8101_RS03755	COG0745	RESPONSE REGULATOR receiver
SynWH8101_RS03805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynWH8101_RS03805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynWH8101_RS03815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH8101_RS03820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynWH8101_RS03825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynWH8101_RS03885	COG5002	protein histidine kinase activity
SynWH8101_RS03905	COG0432	Pfam Uncharacterised protein family UPF0047
SynWH8101_RS03930	COG1492	cobalamin metabolic process
SynWH8101_RS03950	COG0424	maF-like protein
SynWH8101_RS04005	COG2274	protein secretion by the type I secretion system
SynWH8101_RS04050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynWH8101_RS04055	COG0440	acetolactate synthase activity
SynWH8101_RS04060	COG2267	carboxylic ester hydrolase activity
SynWH8101_RS04085	COG2226	methyltransferase
SynWH8101_RS04100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynWH8101_RS04105	COG0492	ferredoxin-NADP+ reductase activity
SynWH8101_RS04145	COG3411	Ferredoxin
SynWH8101_RS04150	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynWH8101_RS04155	COG0733	neurotransmitter:sodium symporter activity
SynWH8101_RS04170	COG0215	cysteine-tRNA ligase activity
SynWH8101_RS04175	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynWH8101_RS04175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynWH8101_RS04180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynWH8101_RS04185	COG0012	GTP binding
SynWH8101_RS04215	COG0601	transmembrane transport
SynWH8101_RS04230	COG0460	homoserine dehydrogenase
SynWH8101_RS04235	COG2166	iron-sulfur cluster assembly
SynWH8101_RS04250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynWH8101_RS04260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynWH8101_RS04265	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynWH8101_RS04280	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynWH8101_RS04285	COG2010	Cytochrome c
SynWH8101_RS04300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynWH8101_RS04305	COG3118	belongs to the thioredoxin family
SynWH8101_RS04310	COG0516	GMP reductase activity
SynWH8101_RS04320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynWH8101_RS04325	COG0644	oxidoreductase
SynWH8101_RS04330	COG1543	Belongs to the glycosyl hydrolase 57 family
SynWH8101_RS04335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynWH8101_RS04340	COG0395	ABC-type sugar transport system, permease component
SynWH8101_RS04360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynWH8101_RS04380	COG0011	TIGRFAM Protein of
SynWH8101_RS04400	COG0564	pseudouridine synthase activity
SynWH8101_RS04405	COG1480	7TM receptor with intracellular HD hydrolase
SynWH8101_RS04410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynWH8101_RS04425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynWH8101_RS04435	COG0406	alpha-ribazole phosphatase activity
SynWH8101_RS04440	COG1254	Belongs to the acylphosphatase family
SynWH8101_RS04445	COG1797	cobyrinic acid a,c-diamide synthase activity
SynWH8101_RS04450	COG3409	Peptidoglycan-binding domain 1 protein
SynWH8101_RS04450	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynWH8101_RS04455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynWH8101_RS04475	COG2205	protein histidine kinase activity
SynWH8101_RS04490	COG0308	aminopeptidase N
SynWH8101_RS04500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynWH8101_RS04515	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SynWH8101_RS04530	COG1187	pseudouridine synthase activity
SynWH8101_RS04535	COG5002	protein histidine kinase activity
SynWH8101_RS04540	COG0745	RESPONSE REGULATOR receiver
SynWH8101_RS04545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_RS04555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynWH8101_RS04560	COG1982	Orn Lys Arg decarboxylase major
SynWH8101_RS04565	COG0575	Belongs to the CDS family
SynWH8101_RS04575	COG2267	carboxylic ester hydrolase activity
SynWH8101_RS04580	COG0371	Dehydrogenase
SynWH8101_RS04585	COG0542	response to heat
SynWH8101_RS04595	COG0019	diaminopimelate decarboxylase activity
SynWH8101_RS04600	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynWH8101_RS04605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynWH8101_RS04610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynWH8101_RS04615	COG1054	Belongs to the UPF0176 family
SynWH8101_RS04630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynWH8101_RS04635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynWH8101_RS04665	COG1285	pathogenesis
SynWH8101_RS04675	COG0589	response to stress
SynWH8101_RS04675	COG0475	glutathione-regulated potassium exporter activity
SynWH8101_RS04680	COG1132	(ABC) transporter
SynWH8101_RS04695	COG0724	RNA recognition motif
SynWH8101_RS04720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynWH8101_RS04730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynWH8101_RS04755	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynWH8101_RS04770	COG0271	Belongs to the BolA IbaG family
SynWH8101_RS04775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynWH8101_RS04785	COG0745	RESPONSE REGULATOR receiver
SynWH8101_RS04810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynWH8101_RS04820	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynWH8101_RS04830	COG0582	viral genome integration into host DNA
SynWH8101_RS04860	COG4243	Vitamin k epoxide reductase
SynWH8101_RS04870	COG0789	Transcriptional regulator
SynWH8101_RS04900	COG5002	protein histidine kinase activity
SynWH8101_RS04915	COG2132	Multicopper oxidase
SynWH8101_RS05000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_RS05015	COG0358	DNA primase activity
SynWH8101_RS05105	COG1487	ribonuclease activity
SynWH8101_RS05125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynWH8101_RS05155	COG1970	mechanosensitive ion channel activity
SynWH8101_RS05170	COG1598	PFAM Uncharacterised protein family UPF0150
SynWH8101_RS05195	COG0724	RNA recognition motif
SynWH8101_RS05225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynWH8101_RS05330	COG1115	amino acid carrier protein
SynWH8101_RS05340	COG0450	alkyl hydroperoxide reductase
SynWH8101_RS05345	COG1615	UPF0182 protein
SynWH8101_RS05350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH8101_RS05355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynWH8101_RS05370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynWH8101_RS05375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynWH8101_RS05375	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynWH8101_RS05395	COG2119	membrane
SynWH8101_RS05405	COG0557	exoribonuclease II activity
SynWH8101_RS05410	COG0163	prenyltransferase activity
SynWH8101_RS05425	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynWH8101_RS05430	COG0312	modulator of DNA gyrase
SynWH8101_RS05440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynWH8101_RS05445	COG0513	Belongs to the DEAD box helicase family
SynWH8101_RS05465	COG0861	Integral membrane protein TerC family
SynWH8101_RS05480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynWH8101_RS05500	COG0793	Belongs to the peptidase S41A family
SynWH8101_RS05505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynWH8101_RS05510	COG1573	uracil-dna glycosylase
SynWH8101_RS05515	COG0436	Aminotransferase
SynWH8101_RS05520	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynWH8101_RS05525	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynWH8101_RS05525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynWH8101_RS05530	COG3639	organic phosphonate transmembrane transporter activity
SynWH8101_RS05545	COG1836	PFAM Integral membrane protein DUF92
SynWH8101_RS05565	COG1122	ATPase activity
SynWH8101_RS05570	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynWH8101_RS05585	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynWH8101_RS05590	COG4106	trans-aconitate 2-methyltransferase activity
SynWH8101_RS05630	COG0640	Transcriptional regulator
SynWH8101_RS05635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynWH8101_RS05720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynWH8101_RS05725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH8101_RS05735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynWH8101_RS05740	COG1429	ligase activity, forming nitrogen-metal bonds
SynWH8101_RS05750	COG5001	Diguanylate cyclase
SynWH8101_RS05755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynWH8101_RS05760	COG0149	triose-phosphate isomerase activity
SynWH8101_RS05770	COG1132	(ABC) transporter
SynWH8101_RS05785	COG1115	amino acid carrier protein
SynWH8101_RS05795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynWH8101_RS05995	COG0010	Belongs to the arginase family
SynWH8101_RS06000	COG0375	protein maturation
SynWH8101_RS06015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynWH8101_RS06020	COG1116	anion transmembrane transporter activity
SynWH8101_RS06070	COG1121	(ABC) transporter
SynWH8101_RS06075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynWH8101_RS06175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_RS06245	COG2226	methyltransferase
SynWH8101_RS06255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_RS06260	COG0358	DNA primase activity
SynWH8101_RS06285	COG3657	addiction module killer protein
SynWH8101_RS06290	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynWH8101_RS06415	COG2197	response regulator
SynWH8101_RS06445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynWH8101_RS06470	COG0659	secondary active sulfate transmembrane transporter activity
SynWH8101_RS06480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynWH8101_RS06485	COG4597	amino acid ABC transporter
SynWH8101_RS06495	COG0765	amino acid transport
SynWH8101_RS06500	COG1126	abc transporter atp-binding protein
SynWH8101_RS06535	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynWH8101_RS06540	COG2873	o-acetylhomoserine
SynWH8101_RS06580	COG0625	glutathione transferase activity
SynWH8101_RS06615	COG0735	belongs to the Fur family
SynWH8101_RS06620	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynWH8101_RS06640	COG0259	pyridoxamine-phosphate oxidase activity
SynWH8101_RS06650	COG0723	plastoquinol--plastocyanin reductase activity
SynWH8101_RS06690	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynWH8101_RS06700	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynWH8101_RS06715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynWH8101_RS06735	COG0656	L-ascorbic acid biosynthetic process
SynWH8101_RS06740	COG0501	Belongs to the peptidase M48B family
SynWH8101_RS06750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynWH8101_RS06750	COG0426	domain, Protein
SynWH8101_RS06755	COG1970	mechanosensitive ion channel activity
SynWH8101_RS06770	COG0739	heme binding
SynWH8101_RS06775	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynWH8101_RS06810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynWH8101_RS06835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SynWH8101_RS06835	COG0784	Response regulator, receiver
SynWH8101_RS06840	COG0402	S-adenosylhomocysteine deaminase activity
SynWH8101_RS06850	COG2197	response regulator
SynWH8101_RS06860	COG2274	protein secretion by the type I secretion system
SynWH8101_RS06865	COG1132	(ABC) transporter
SynWH8101_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
SynWH8101_RS06940	COG0557	exoribonuclease II activity
SynWH8101_RS06945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynWH8101_RS06950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynWH8101_RS06955	COG0072	phenylalanine-tRNA ligase activity
SynWH8101_RS06955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynWH8101_RS06960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynWH8101_RS06995	COG2385	sporulation resulting in formation of a cellular spore
SynWH8101_RS07020	COG0646	methionine synthase
SynWH8101_RS07020	COG1410	methionine synthase
SynWH8101_RS07025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynWH8101_RS07040	COG0613	PHP domain protein
SynWH8101_RS07045	COG1981	membrane
SynWH8101_RS07050	COG3046	protein related to deoxyribodipyrimidine photolyase
SynWH8101_RS07060	COG0322	excinuclease ABC activity
SynWH8101_RS07090	COG1104	cysteine desulfurase activity
SynWH8101_RS07095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynWH8101_RS07105	COG0495	leucyl-tRNA aminoacylation
SynWH8101_RS07110	COG0166	Belongs to the GPI family
SynWH8101_RS07135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynWH8101_RS07140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynWH8101_RS07145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynWH8101_RS07145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynWH8101_RS07150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynWH8101_RS07155	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynWH8101_RS07160	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynWH8101_RS07170	COG0484	heat shock protein binding
SynWH8101_RS07175	COG0443	Heat shock 70 kDa protein
SynWH8101_RS07180	COG0573	inorganic phosphate transmembrane transporter activity
SynWH8101_RS07185	COG0581	inorganic phosphate transmembrane transporter activity
SynWH8101_RS07190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynWH8101_RS07200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynWH8101_RS07205	COG0483	inositol monophosphate 1-phosphatase activity
SynWH8101_RS07210	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynWH8101_RS07220	COG0326	Molecular chaperone. Has ATPase activity
SynWH8101_RS07225	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynWH8101_RS07230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynWH8101_RS07235	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynWH8101_RS07240	COG1653	transport
SynWH8101_RS07270	COG0598	Magnesium transport protein CorA
SynWH8101_RS07275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynWH8101_RS07305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynWH8101_RS07310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynWH8101_RS07330	COG0469	pyruvate kinase activity
SynWH8101_RS07335	COG1136	(ABC) transporter
SynWH8101_RS07335	COG0577	efflux transmembrane transporter activity
SynWH8101_RS07340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH8101_RS07350	COG0740	serine-type endopeptidase activity
SynWH8101_RS07370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynWH8101_RS07375	COG2211	Major facilitator Superfamily
SynWH8101_RS07395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynWH8101_RS07400	COG1175	transmembrane transport
SynWH8101_RS07405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynWH8101_RS07440	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SynWH8101_RS07440	COG1793	dna ligase
SynWH8101_RS07450	COG1793	dna ligase
SynWH8101_RS07455	COG1201	RNA secondary structure unwinding
SynWH8101_RS07495	COG3659	wide pore channel activity
SynWH8101_RS07515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynWH8101_RS07540	COG1376	ErfK ybiS ycfS ynhG family protein
SynWH8101_RS07555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SynWH8101_RS07575	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynWH8101_RS07585	COG2197	response regulator
SynWH8101_RS07590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynWH8101_RS07605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynWH8101_RS07620	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynWH8101_RS07625	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynWH8101_RS07630	COG0473	3-isopropylmalate dehydrogenase activity
SynWH8101_RS07635	COG3954	Phosphoribulokinase
SynWH8101_RS07645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynWH8101_RS07650	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynWH8101_RS07660	COG0673	inositol 2-dehydrogenase activity
SynWH8101_RS07665	COG0191	fructose-bisphosphate aldolase activity
SynWH8101_RS07670	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynWH8101_RS07675	COG0047	phosphoribosylformylglycinamidine synthase activity
SynWH8101_RS07680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynWH8101_RS07695	COG2211	Major facilitator Superfamily
SynWH8101_RS07710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynWH8101_RS07720	COG0129	dihydroxy-acid dehydratase activity
SynWH8101_RS07745	COG0363	glucosamine-6-phosphate deaminase activity
SynWH8101_RS07750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynWH8101_RS07755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynWH8101_RS07760	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynWH8101_RS07765	COG1494	fructose-1,6-bisphosphatase
SynWH8101_RS07770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynWH8101_RS07775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynWH8101_RS07800	COG1217	gtp-binding protein TYPA
SynWH8101_RS07805	COG0826	peptidase U32
SynWH8101_RS07815	COG0644	oxidoreductase
SynWH8101_RS07820	COG0751	glycine-tRNA ligase activity
SynWH8101_RS07825	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynWH8101_RS07830	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynWH8101_RS07835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynWH8101_RS07845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynWH8101_RS07850	COG0052	Belongs to the universal ribosomal protein uS2 family
SynWH8101_RS07855	COG1216	Glycosyl transferase, family 2
SynWH8101_RS07865	COG1136	(ABC) transporter
SynWH8101_RS07865	COG0577	efflux transmembrane transporter activity
SynWH8101_RS07885	COG0612	Peptidase, M16
SynWH8101_RS07905	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynWH8101_RS07910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynWH8101_RS07930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynWH8101_RS07940	COG0174	glutamine synthetase
SynWH8101_RS07950	COG2226	methyltransferase
SynWH8101_RS07975	COG0515	serine threonine protein kinase
SynWH8101_RS07980	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynWH8101_RS07990	COG0628	permease
SynWH8101_RS08010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynWH8101_RS08015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynWH8101_RS08020	COG0022	dehydrogenase e1 component
SynWH8101_RS08030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynWH8101_RS08035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynWH8101_RS08040	COG0668	transmembrane transport
SynWH8101_RS08045	COG0792	nuclease activity
SynWH8101_RS08060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynWH8101_RS08075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynWH8101_RS08100	COG0798	PFAM Bile acid sodium symporter
SynWH8101_RS08110	COG0358	DNA primase activity
SynWH8101_RS08125	COG0632	four-way junction helicase activity
SynWH8101_RS08130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynWH8101_RS08140	COG0587	DNA-directed DNA polymerase activity
SynWH8101_RS08145	COG0154	amidase activity
SynWH8101_RS08155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynWH8101_RS08160	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynWH8101_RS08170	COG0505	Belongs to the CarA family
SynWH8101_RS08175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynWH8101_RS08180	COG1132	(ABC) transporter
SynWH8101_RS08190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynWH8101_RS08205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynWH8101_RS08210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynWH8101_RS08220	COG2176	DNA-directed DNA polymerase activity
SynWH8101_RS08225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynWH8101_RS08235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynWH8101_RS08240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynWH8101_RS08245	COG0142	geranyltranstransferase activity
SynWH8101_RS08250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynWH8101_RS08265	COG2045	Belongs to the ComB family
SynWH8101_RS08270	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynWH8101_RS08275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynWH8101_RS08280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynWH8101_RS08280	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SynWH8101_RS08285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynWH8101_RS08290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynWH8101_RS08300	COG0297	glycogen (starch) synthase activity
SynWH8101_RS08305	COG1376	ErfK ybiS ycfS ynhG family protein
SynWH8101_RS08310	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynWH8101_RS08315	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynWH8101_RS08320	COG0681	Belongs to the peptidase S26 family
SynWH8101_RS08370	COG2274	protein secretion by the type I secretion system
SynWH8101_RS08390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynWH8101_RS08395	COG0071	Belongs to the small heat shock protein (HSP20) family
SynWH8101_RS08405	COG1881	PFAM PEBP family protein
SynWH8101_RS08430	COG1032	radical SAM domain protein
SynWH8101_RS08455	COG0574	Belongs to the PEP-utilizing enzyme family
SynWH8101_RS08455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SynWH8101_RS08485	COG1271	oxidase subunit
SynWH8101_RS08490	COG1294	oxidase, subunit
SynWH8101_RS08495	COG0450	alkyl hydroperoxide reductase
SynWH8101_RS08500	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SynWH8101_RS08510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynWH8101_RS08515	COG1121	(ABC) transporter
SynWH8101_RS08525	COG3659	wide pore channel activity
SynWH8101_RS08530	COG2010	Cytochrome c
SynWH8101_RS08535	COG1006	Multisubunit Na H antiporter MnhC subunit
SynWH8101_RS08580	COG0701	Predicted permease
SynWH8101_RS08585	COG2010	Cytochrome c
SynWH8101_RS08620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynWH8101_RS08635	COG0367	asparagine synthase
SynWH8101_RS08640	COG0540	Belongs to the ATCase OTCase family
SynWH8101_RS08655	COG1121	(ABC) transporter
SynWH8101_RS08675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynWH8101_RS08680	COG0390	transport system, permease component
SynWH8101_RS08725	COG3039	Transposase
SynWH8101_RS08755	COG2094	Belongs to the DNA glycosylase MPG family
SynWH8101_RS08810	COG2094	Belongs to the DNA glycosylase MPG family
SynWH8101_RS08835	COG2274	protein secretion by the type I secretion system
SynWH8101_RS08920	COG0028	Belongs to the TPP enzyme family
SynWH8101_RS08965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynWH8101_RS08980	COG1064	alcohol dehydrogenase
SynWH8101_RS09000	COG3781	membrane
SynWH8101_RS09020	COG2226	methyltransferase
SynWH8101_RS09055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynWH8101_RS09060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH8101_RS09085	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynWH8101_RS09115	COG0180	Tryptophanyl-tRNA synthetase
SynWH8101_RS09135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynWH8101_RS09145	COG0837	glucose binding
SynWH8101_RS09150	COG0083	homoserine kinase activity
SynWH8101_RS09155	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_RS09160	COG0339	signal peptide processing
SynWH8101_RS09190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SynWH8101_RS09195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynWH8101_RS09235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynWH8101_RS09240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynWH8101_RS09250	COG3794	PFAM blue (type 1) copper domain protein
SynWH8101_RS09255	COG2010	Cytochrome c
SynWH8101_RS09270	COG0542	response to heat
SynWH8101_RS09280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynWH8101_RS09280	COG0140	phosphoribosyl-ATP diphosphatase activity
SynWH8101_RS09295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_RS09345	COG0159	tryptophan synthase activity
SynWH8101_RS09370	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynWH8101_RS09370	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynWH8101_RS09400	COG0251	oxidation-reduction process
SynWH8101_RS09415	COG0418	dihydroorotase activity
SynWH8101_RS09420	COG0659	secondary active sulfate transmembrane transporter activity
SynWH8101_RS09445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynWH8101_RS09450	COG1845	cytochrome c oxidase, subunit III
SynWH8101_RS09480	COG0811	peptide transport
SynWH8101_RS09490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SynWH8101_RS09495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynWH8101_RS09510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynWH8101_RS09535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynWH8101_RS09540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynWH8101_RS09555	COG0456	acetyltransferase
SynWH8101_RS09565	COG1132	(ABC) transporter
SynWH8101_RS09570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynWH8101_RS09575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynWH8101_RS09580	COG3842	ATPase activity
SynWH8101_RS09585	COG0251	oxidation-reduction process
SynWH8101_RS09615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_RS09620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynWH8101_RS09625	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynWH8101_RS09655	COG4451	ribulose bisphosphate carboxylase, small
SynWH8101_RS09660	COG1850	ribulose-bisphosphate carboxylase activity
SynWH8101_RS09665	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynWH8101_RS09670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynWH8101_RS09675	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynWH8101_RS09690	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynWH8101_RS09695	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynWH8101_RS09700	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynWH8101_RS09725	COG0730	response to heat
SynWH8101_RS09730	COG0095	Lipoate-protein ligase
SynWH8101_RS09735	COG1994	Peptidase M50
SynWH8101_RS09735	COG0517	IMP dehydrogenase activity
SynWH8101_RS09740	COG0135	phosphoribosylanthranilate isomerase activity
SynWH8101_RS09750	COG0302	gtp cyclohydrolase
SynWH8101_RS09755	COG1028	Short-chain dehydrogenase reductase Sdr
SynWH8101_RS09760	COG0825	malonyl-CoA metabolic process
SynWH8101_RS09765	COG5322	oxidoreductase activity
SynWH8101_RS09770	COG3396	Phenylacetate-CoA oxygenase
SynWH8101_RS09780	COG0539	negative regulation of cytoplasmic translation
SynWH8101_RS09795	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynWH8101_RS09815	COG0028	Belongs to the TPP enzyme family
SynWH8101_RS09820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH8101_RS09825	COG0582	viral genome integration into host DNA
SynWH8101_RS09830	COG2226	methyltransferase
SynWH8101_RS09845	COG0528	UMP kinase activity
SynWH8101_RS09850	COG0233	cytoplasmic translational termination
SynWH8101_RS09860	COG0415	Belongs to the DNA photolyase family
SynWH8101_RS09870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynWH8101_RS09895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SynWH8101_RS09900	COG0681	Belongs to the peptidase S26 family
SynWH8101_RS09920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynWH8101_RS09930	COG0442	prolyl-tRNA aminoacylation
SynWH8101_RS09940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynWH8101_RS09945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynWH8101_RS09975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynWH8101_RS09985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynWH8101_RS09990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_RS10005	COG2095	MarC family integral membrane protein
SynWH8101_RS10015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynWH8101_RS10085	COG2267	carboxylic ester hydrolase activity
SynWH8101_RS10220	COG0590	tRNA wobble adenosine to inosine editing
SynWH8101_RS10225	COG0484	heat shock protein binding
SynWH8101_RS10255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynWH8101_RS10280	COG0674	pyruvate-flavodoxin oxidoreductase activity
SynWH8101_RS10280	COG1013	pyruvate-flavodoxin oxidoreductase activity
SynWH8101_RS10280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SynWH8101_RS10280	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SynWH8101_RS10295	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynWH8101_RS10300	COG0375	protein maturation
SynWH8101_RS10310	COG3259	Nickel-dependent hydrogenase
SynWH8101_RS10320	COG1034	ATP synthesis coupled electron transport
SynWH8101_RS10335	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynWH8101_RS10410	COG2135	peptidase activity
SynWH8101_RS10445	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynWH8101_RS10455	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynWH8101_RS10465	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynWH8101_RS10470	COG0523	cobalamin synthesis protein
SynWH8101_RS10475	COG1840	ABC-type Fe3 transport system, periplasmic component
SynWH8101_RS10495	COG1230	cation diffusion facilitator family transporter
SynWH8101_RS10500	COG2814	Major facilitator Superfamily
SynWH8101_RS10510	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynWH8101_RS10535	COG0708	Exodeoxyribonuclease III
SynWH8101_RS10540	COG0277	FAD linked oxidase domain protein
SynWH8101_RS10545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynWH8101_RS10555	COG1666	GTP binding
SynWH8101_RS10565	COG0330	HflC and HflK could
SynWH8101_RS10580	COG0857	belongs to the CobB CobQ family
SynWH8101_RS10590	COG3000	fatty acid hydroxylase
SynWH8101_RS10590	COG0300	oxidoreductase activity
SynWH8101_RS10595	COG0024	Methionine aminopeptidase
SynWH8101_RS10605	COG0335	large ribosomal subunit rRNA binding
SynWH8101_RS10625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynWH8101_RS10650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH8101_RS10655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynWH8101_RS10670	COG0194	GDP metabolic process
SynWH8101_RS10680	COG0805	protein transport
SynWH8101_RS10690	COG0723	plastoquinol--plastocyanin reductase activity
SynWH8101_RS10695	COG3258	Cytochrome c
SynWH8101_RS10720	COG0248	Ppx GppA phosphatase
SynWH8101_RS10725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynWH8101_RS10735	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynWH8101_RS10745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynWH8101_RS10750	COG1028	Short-chain dehydrogenase reductase Sdr
SynWH8101_RS10760	COG0459	protein refolding
SynWH8101_RS10770	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynWH8101_RS10790	COG0109	protoheme IX farnesyltransferase activity
SynWH8101_RS10795	COG1612	heme a metabolic process
SynWH8101_RS10805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynWH8101_RS10810	COG1845	cytochrome c oxidase, subunit III
SynWH8101_RS10845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynWH8101_RS10860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynWH8101_RS10865	COG1007	ATP synthesis coupled electron transport
SynWH8101_RS10870	COG1136	(ABC) transporter
SynWH8101_RS10875	COG0745	RESPONSE REGULATOR receiver
SynWH8101_RS10880	COG0739	heme binding
SynWH8101_RS10890	COG0436	Aminotransferase
SynWH8101_RS10895	COG3118	belongs to the thioredoxin family
SynWH8101_RS10900	COG1842	Phage shock protein A
SynWH8101_RS10910	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynWH8101_RS10915	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_RS10920	COG0697	spore germination
SynWH8101_RS10925	COG0616	signal peptide processing
SynWH8101_RS10940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynWH8101_RS10945	COG0594	ribonuclease P activity
SynWH8101_RS10955	COG0706	membrane insertase activity
SynWH8101_RS10965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH8101_RS10970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynWH8101_RS10975	COG0750	zinc metalloprotease
SynWH8101_RS10980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynWH8101_RS10985	COG1185	polyribonucleotide nucleotidyltransferase activity
SynWH8101_RS11000	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynWH8101_RS11035	COG3039	Transposase
SynWH8101_RS11055	COG0776	regulation of translation
SynWH8101_RS11075	COG2211	Major facilitator Superfamily
SynWH8101_RS11080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynWH8101_RS11095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynWH8101_RS11100	COG0284	orotidine-5'-phosphate decarboxylase activity
SynWH8101_RS11105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynWH8101_RS11115	COG2197	response regulator
SynWH8101_RS11130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynWH8101_RS11150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynWH8101_RS11155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynWH8101_RS11160	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynWH8101_RS11170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynWH8101_RS11180	COG0151	Belongs to the GarS family
SynWH8101_RS11185	COG5002	protein histidine kinase activity
SynWH8101_RS11190	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynWH8101_RS11195	COG4251	negative regulation of phosphorylation
SynWH8101_RS11205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynWH8101_RS11210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynWH8101_RS11220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynWH8101_RS11225	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynWH8101_RS11230	COG0217	transcriptional regulatory protein
SynWH8101_RS11235	COG0363	glucosamine-6-phosphate deaminase activity
SynWH8101_RS11240	COG2385	sporulation resulting in formation of a cellular spore
SynWH8101_RS11245	COG1234	tRNA 3'-trailer cleavage
SynWH8101_RS11250	COG2010	Cytochrome c
SynWH8101_RS11265	COG2264	protein methyltransferase activity
SynWH8101_RS11270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynWH8101_RS11290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynWH8101_RS11325	COG0443	Heat shock 70 kDa protein
SynWH8101_RS11340	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynWH8101_RS11345	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynWH8101_RS11355	COG0459	protein refolding
SynWH8101_RS11360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynWH8101_RS11365	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynWH8101_RS11370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynWH8101_RS11385	COG0387	Pfam Sodium calcium exchanger
SynWH8101_RS11390	COG0006	proline dipeptidase activity
SynWH8101_RS11395	COG1253	flavin adenine dinucleotide binding
SynWH8101_RS11400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynWH8101_RS11405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynWH8101_RS11410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynWH8101_RS11410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynWH8101_RS11420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynWH8101_RS11430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynWH8101_RS11440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynWH8101_RS11445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynWH8101_RS11450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynWH8101_RS11455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynWH8101_RS11460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynWH8101_RS11465	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynWH8101_RS11470	COG0356	it plays a direct role in the translocation of protons across the membrane
SynWH8101_RS11480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynWH8101_RS11485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynWH8101_RS11505	COG0772	Belongs to the SEDS family
SynWH8101_RS11515	COG1333	cytochrome c biogenesis protein
SynWH8101_RS11520	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynWH8101_RS11535	COG0347	Belongs to the P(II) protein family
SynWH8101_RS11550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynWH8101_RS11560	COG0114	fumarate hydratase activity
SynWH8101_RS11565	COG4581	dead DEAH box helicase
SynWH8101_RS11570	COG0385	Bile acid
SynWH8101_RS11590	COG4106	trans-aconitate 2-methyltransferase activity
SynWH8101_RS11590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynWH8101_RS11605	COG0484	heat shock protein binding
SynWH8101_RS11610	COG0357	Ribosomal RNA small subunit methyltransferase G
SynWH8101_RS11640	COG2223	nitrite transmembrane transporter activity
SynWH8101_RS11645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynWH8101_RS11655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynWH8101_RS11660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynWH8101_RS11665	COG0085	RNA polymerase activity
SynWH8101_RS11670	COG0084	hydrolase, TatD family'
SynWH8101_RS11675	COG0268	Binds directly to 16S ribosomal RNA
SynWH8101_RS11680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynWH8101_RS11685	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynWH8101_RS11690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynWH8101_RS11705	COG0668	transmembrane transport
SynWH8101_RS11720	COG0641	radical SAM
SynWH8101_RS11725	COG0779	Required for maturation of 30S ribosomal subunits
SynWH8101_RS11730	COG0195	Participates in both transcription termination and antitermination
SynWH8101_RS11740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynWH8101_RS11780	COG2988	succinylglutamate desuccinylase activity
SynWH8101_RS11785	COG0435	Glutathione S-transferase
SynWH8101_RS11795	COG0488	(ABC) transporter
SynWH8101_RS11815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynWH8101_RS11820	COG3842	ATPase activity
SynWH8101_RS11825	COG1193	negative regulation of DNA recombination
SynWH8101_RS11860	COG0113	porphobilinogen synthase activity
SynWH8101_RS11865	COG0484	heat shock protein binding
SynWH8101_RS11875	COG0659	secondary active sulfate transmembrane transporter activity
SynWH8101_RS11890	COG0116	Belongs to the methyltransferase superfamily
SynWH8101_RS11910	COG1196	nuclear chromosome segregation
SynWH8101_RS11920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynWH8101_RS11935	COG0439	Biotin carboxylase
SynWH8101_RS11950	COG0515	serine threonine protein kinase
SynWH8101_RS11970	COG4178	(ABC) transporter
SynWH8101_RS11975	COG0537	adenosine 5'-monophosphoramidase activity
SynWH8101_RS11985	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynWH8101_RS12000	COG0242	peptide deformylase activity
SynWH8101_RS12010	COG0235	Class ii aldolase
SynWH8101_RS12015	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynWH8101_RS12030	COG1231	oxidoreductase activity
SynWH8101_RS12040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynWH8101_RS12045	COG0719	Fe-S assembly protein
SynWH8101_RS12050	COG0396	ATPase activity
SynWH8101_RS12055	COG0719	Fe-S assembly protein
SynWH8101_RS12060	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynWH8101_RS12065	COG1830	Aldolase
SynWH8101_RS12085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynWH8101_RS12135	COG0457	Tetratricopeptide repeat
SynWH8101_RS12150	COG0033	Phosphoglucomutase
SynWH8101_RS12160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynWH8101_RS12165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynWH8101_RS12190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynWH8101_RS12195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynWH8101_RS12200	COG0175	sulfate reduction
SynWH8101_RS12205	COG1252	NADH dehydrogenase
SynWH8101_RS12210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynWH8101_RS12215	COG3273	potassium ion transport
SynWH8101_RS12215	COG0471	metal ion transport
SynWH8101_RS12220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynWH8101_RS12225	COG0569	domain protein
SynWH8101_RS12230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynWH8101_RS12255	COG0488	(ABC) transporter
SynWH8101_RS12265	COG3039	Transposase
SynWH8101_RS12270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynWH8101_RS12285	COG1643	Atp-dependent helicase
SynWH8101_RS12290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH8101_RS12295	COG1570	exodeoxyribonuclease VII activity
SynWH8101_RS12345	COG0483	inositol monophosphate 1-phosphatase activity
SynWH8101_RS12360	COG1968	undecaprenyl-diphosphatase activity
SynWH8101_RS12370	COG1555	photosystem II stabilization
SynWH8101_RS12375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynWH8101_RS12380	COG4243	Vitamin k epoxide reductase
SynWH8101_RS12385	COG0668	transmembrane transport
SynWH8101_RS12390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynWH8101_RS12405	COG1032	radical SAM domain protein
SynWH8101_RS12465	COG1472	Belongs to the glycosyl hydrolase 3 family
SynWH8101_RS12470	COG0457	Tetratricopeptide repeat
SynWH8101_RS12470	COG0463	Glycosyl transferase, family 2
SynWH8101_RS12475	COG1587	Uroporphyrinogen-III synthase
SynWH8101_RS12490	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynWH8101_RS12495	COG0316	Belongs to the HesB IscA family
SynWH8101_RS12515	COG1090	epimerase
SynWH8101_RS12535	COG0484	heat shock protein binding
SynWH8101_RS12540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynWH8101_RS12545	COG3659	wide pore channel activity
SynWH8101_RS12550	COG3659	wide pore channel activity
SynWH8101_RS12555	COG3659	wide pore channel activity
SynWH8101_RS12580	COG1122	ATPase activity
SynWH8101_RS12590	COG0745	RESPONSE REGULATOR receiver
SynWH8101_RS12600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynWH8101_RS12605	COG2217	Heavy metal translocating P-type atpase
SynWH8101_RS12610	COG3063	Type IV pilus biogenesis stability protein PilW
SynWH8101_RS12615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynWH8101_RS12625	COG0416	fatty acid biosynthetic process
SynWH8101_RS12630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynWH8101_RS12635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynWH8101_RS12640	COG0204	Acyl-transferase
SynWH8101_RS12640	COG0318	PFAM AMP-dependent synthetase and ligase
SynWH8101_RS12650	COG1214	PFAM Peptidase M22, glycoprotease
SynWH8101_RS12660	COG0617	tRNA 3'-terminal CCA addition
SynWH8101_RS12670	COG1562	ergosterol biosynthetic process
SynWH8101_RS12675	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynWH8101_RS12675	COG0493	'glutamate synthase
SynWH8101_RS12690	COG0583	DNA-binding transcription factor activity
SynWH8101_RS12700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynWH8101_RS12705	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_RS12715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynWH8101_RS12725	COG2197	response regulator
SynWH8101_RS12735	COG2954	triphosphatase activity
SynWH8101_RS12740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynWH8101_RS12745	COG0713	ATP synthesis coupled electron transport
SynWH8101_RS12760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynWH8101_RS12765	COG0372	Belongs to the citrate synthase family
SynWH8101_RS12785	COG1420	regulation of RNA biosynthetic process
SynWH8101_RS12790	COG0133	tryptophan synthase activity
SynWH8101_RS12795	COG0023	Translation Initiation Factor
SynWH8101_RS12800	COG0529	Catalyzes the synthesis of activated sulfate
SynWH8101_RS12805	COG0628	permease
SynWH8101_RS12810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynWH8101_RS12820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynWH8101_RS12825	COG0564	pseudouridine synthase activity
SynWH8101_RS12830	COG0745	RESPONSE REGULATOR receiver
SynWH8101_RS12840	COG1104	cysteine desulfurase activity
SynWH8101_RS12860	COG0275	rRNA processing
SynWH8101_RS12865	COG0649	NAD binding
SynWH8101_RS12870	COG0824	Thioesterase
SynWH8101_RS12880	COG0318	PFAM AMP-dependent synthetase and ligase
SynWH8101_RS12885	COG4948	Mandelate Racemase Muconate Lactonizing
SynWH8101_RS12890	COG1575	Belongs to the MenA family. Type 1 subfamily
SynWH8101_RS12900	COG0189	ligase activity
SynWH8101_RS12905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynWH8101_RS12930	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynWH8101_RS12935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynWH8101_RS12950	COG0252	asparaginase activity
SynWH8101_RS12955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynWH8101_RS12960	COG0018	arginyl-trna synthetase
SynWH8101_RS12970	COG0157	Belongs to the NadC ModD family
SynWH8101_RS12980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynWH8101_RS13005	COG4106	trans-aconitate 2-methyltransferase activity
SynWH8101_RS13010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynWH8101_RS13015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynWH8101_RS13020	COG4172	Belongs to the ABC transporter superfamily
SynWH8101_RS13030	COG0564	pseudouridine synthase activity
SynWH8101_RS13035	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynWH8101_RS13040	COG0589	response to stress
SynWH8101_RS13045	COG0126	phosphoglycerate kinase activity
SynWH8101_RS13055	COG2084	Dehydrogenase
SynWH8101_RS13065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynWH8101_RS13070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynWH8101_RS13095	COG0167	dihydroorotate dehydrogenase activity
SynWH8101_RS13100	COG0328	RNA-DNA hybrid ribonuclease activity
SynWH8101_RS13110	COG0222	ribosome binding
SynWH8101_RS13115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynWH8101_RS13120	COG0081	regulation of translation
SynWH8101_RS13125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynWH8101_RS13130	COG0250	Participates in transcription elongation, termination and antitermination
SynWH8101_RS13135	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynWH8101_RS13140	COG0542	response to heat
SynWH8101_RS13145	COG0346	lactoylglutathione lyase activity
SynWH8101_RS13150	COG0148	phosphopyruvate hydratase activity
SynWH8101_RS13165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynWH8101_RS13180	COG4974	Belongs to the 'phage' integrase family
SynWH8101_RS13195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynWH8101_RS13200	COG0237	dephospho-CoA kinase activity
SynWH8101_RS13220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynWH8101_RS13225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynWH8101_RS13225	COG2022	thiamine diphosphate biosynthetic process
SynWH8101_RS13230	COG0105	UTP biosynthetic process
SynWH8101_RS13245	COG1166	arginine decarboxylase activity
SynWH8101_RS13265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynWH8101_RS13275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynWH8101_RS13290	COG0071	Belongs to the small heat shock protein (HSP20) family
SynWH8101_RS13300	COG0426	domain, Protein
SynWH8101_RS13300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynWH8101_RS13305	COG0426	domain, Protein
SynWH8101_RS13305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynWH8101_RS13310	COG1773	rubredoxin
SynWH8101_RS13320	COG1741	Belongs to the pirin family
SynWH8101_RS13340	COG0509	glycine decarboxylation via glycine cleavage system
SynWH8101_RS13345	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynWH8101_RS13365	COG0359	binds to the 23S rRNA
SynWH8101_RS13370	COG1372	Participates in initiation and elongation during chromosome replication
SynWH8101_RS13370	COG0305	Participates in initiation and elongation during chromosome replication
SynWH8101_RS13370	COG1372	Participates in initiation and elongation during chromosome replication
SynWH8101_RS13370	COG0305	Participates in initiation and elongation during chromosome replication
SynWH8101_RS13375	COG0445	tRNA wobble uridine modification
SynWH8101_RS13415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynWH8101_RS13425	COG0398	Pfam SNARE associated Golgi protein
SynWH8101_RS13430	COG0668	transmembrane transport
SynWH8101_RS13435	COG0525	valine-tRNA ligase activity
SynWH8101_RS13445	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynWH8101_RS13445	COG3264	Mechanosensitive ion channel
SynWH8101_RS13465	COG4221	oxidoreductase activity
SynWH8101_RS13485	COG3956	TIGRFAM MazG family protein
SynWH8101_RS13495	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynWH8101_RS13505	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynWH8101_RS13510	COG0010	Belongs to the arginase family
SynWH8101_RS13530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynWH8101_RS13535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_RS13540	COG0783	Belongs to the Dps family
SynWH8101_RS13545	COG0504	CTP synthase activity
SynWH8101_RS13550	COG0602	queuosine metabolic process
SynWH8101_RS13555	COG4574	serine-type endopeptidase inhibitor activity
SynWH8101_RS13560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynWH8101_RS13570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynWH8101_RS13575	COG0531	amino acid
SynWH8101_RS13600	COG0559	Belongs to the binding-protein-dependent transport system permease family
SynWH8101_RS13610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynWH8101_RS13615	COG0830	nickel cation binding
SynWH8101_RS13620	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynWH8101_RS13625	COG0829	nickel cation binding
SynWH8101_RS13630	COG0831	urea catabolic process
SynWH8101_RS13635	COG0832	Belongs to the urease beta subunit family
SynWH8101_RS13640	COG0804	urea catabolic process
SynWH8101_RS13650	COG2308	Evidence 4 Homologs of previously reported genes of
SynWH8101_RS13670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynWH8101_RS13675	COG0746	molybdenum cofactor guanylyltransferase activity
SynWH8101_RS13680	COG2223	nitrite transmembrane transporter activity
SynWH8101_RS13685	COG0243	molybdopterin cofactor binding
SynWH8101_RS13700	COG0315	cyclic pyranopterin monophosphate synthase activity
SynWH8101_RS13710	COG0314	molybdopterin synthase activity
SynWH8101_RS13720	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynWH8101_RS13725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynWH8101_RS13735	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynWH8101_RS13745	COG2116	formate transmembrane transporter activity
SynWH8101_RS13755	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynWH8101_RS13760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynWH8101_RS13770	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynWH8101_RS13775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_RS13780	COG0170	dolichyl monophosphate biosynthetic process
SynWH8101_RS13790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynWH8101_RS13795	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynWH8101_RS13815	COG0788	formyltetrahydrofolate deformylase activity
SynWH8101_RS13825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynWH8101_RS13825	COG2022	thiamine diphosphate biosynthetic process
SynWH8101_RS13835	COG0443	Heat shock 70 kDa protein
SynWH8101_RS13840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynWH8101_RS13850	COG0360	Binds together with S18 to 16S ribosomal RNA
SynWH8101_RS13860	COG0137	argininosuccinate synthase activity
SynWH8101_RS13875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynWH8101_RS13900	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynWH8101_RS13905	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_RS13915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynWH8101_RS13920	COG0497	DNA recombination
SynWH8101_RS13925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynWH8101_RS13935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine