locus-tag	class	description
TX72_RS00005	COG0592	DNA-directed DNA polymerase activity
TX72_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TX72_RS00020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TX72_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TX72_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TX72_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TX72_RS00055	COG0552	protein localization to endoplasmic reticulum
TX72_RS00060	COG2208	phosphoserine phosphatase activity
TX72_RS00065	COG0165	Argininosuccinate lyase
TX72_RS00070	COG0724	RNA recognition motif
TX72_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TX72_RS00080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TX72_RS00085	COG2081	HI0933 family
TX72_RS00090	COG1459	type II secretion system
TX72_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TX72_RS00105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TX72_RS00110	COG0484	heat shock protein binding
TX72_RS00120	COG1162	GTPase activity
TX72_RS00125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TX72_RS00130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TX72_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TX72_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TX72_RS00145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TX72_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TX72_RS00155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TX72_RS00160	COG0511	ligase activity, forming carbon-carbon bonds
TX72_RS00165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TX72_RS00225	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TX72_RS00230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TX72_RS00230	COG0519	Catalyzes the synthesis of GMP from XMP
TX72_RS00245	COG0768	penicillin binding
TX72_RS00250	COG0438	transferase activity, transferring glycosyl groups
TX72_RS00255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TX72_RS00265	COG2022	thiamine diphosphate biosynthetic process
TX72_RS00280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TX72_RS00285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TX72_RS00290	COG2385	sporulation resulting in formation of a cellular spore
TX72_RS00295	COG1215	transferase activity, transferring glycosyl groups
TX72_RS00310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TX72_RS00315	COG0740	serine-type endopeptidase activity
TX72_RS00320	COG0544	peptidyl-prolyl cis-trans isomerase activity
TX72_RS00325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TX72_RS00330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TX72_RS00335	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TX72_RS00365	COG2082	Precorrin-8x methylmutase
TX72_RS00370	COG0037	tRNA processing
TX72_RS00380	COG0556	nucleotide-excision repair
TX72_RS00385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TX72_RS00405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TX72_RS00440	COG0653	protein targeting
TX72_RS00460	COG1045	serine acetyltransferase
TX72_RS00465	COG1725	Transcriptional regulator
TX72_RS00470	COG0412	Dienelactone hydrolase
TX72_RS00475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TX72_RS00480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TX72_RS00485	COG0187	DNA topoisomerase II activity
TX72_RS00485	COG1372	Participates in initiation and elongation during chromosome replication
TX72_RS00495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TX72_RS00500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TX72_RS00505	COG0386	Belongs to the glutathione peroxidase family
TX72_RS00515	COG2239	Acts as a magnesium transporter
TX72_RS00520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX72_RS00570	COG2015	COG2015, Alkyl sulfatase and related hydrolases
TX72_RS00595	COG0802	atpase or kinase
TX72_RS00600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TX72_RS00605	COG0586	Pfam SNARE associated Golgi protein
TX72_RS00610	COG0629	single-stranded DNA binding
TX72_RS00635	COG0745	RESPONSE REGULATOR receiver
TX72_RS00640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TX72_RS00660	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TX72_RS00665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TX72_RS00675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TX72_RS00680	COG2255	four-way junction helicase activity
TX72_RS00690	COG1473	amidohydrolase
TX72_RS00705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TX72_RS00710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TX72_RS00715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TX72_RS00720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TX72_RS00725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX72_RS00730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TX72_RS00745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TX72_RS00755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TX72_RS00760	COG0571	ribonuclease III activity
TX72_RS00780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TX72_RS00785	COG0058	SHG alpha-glucan phosphorylase activity
TX72_RS00790	COG0475	glutathione-regulated potassium exporter activity
TX72_RS00810	COG0277	FAD linked oxidase domain protein
TX72_RS00820	COG0247	lactate metabolic process
TX72_RS00830	COG0538	isocitrate dehydrogenase activity
TX72_RS00835	COG0463	Glycosyl transferase, family 2
TX72_RS00845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TX72_RS00855	COG5398	heme oxygenase
TX72_RS00865	COG1132	(ABC) transporter
TX72_RS00870	COG0438	transferase activity, transferring glycosyl groups
TX72_RS00895	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TX72_RS00915	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TX72_RS00925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TX72_RS00930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TX72_RS00930	COG0517	IMP dehydrogenase activity
TX72_RS00935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TX72_RS00935	COG0617	tRNA 3'-terminal CCA addition
TX72_RS00935	COG0517	IMP dehydrogenase activity
TX72_RS00945	COG0709	Synthesizes selenophosphate from selenide and ATP
TX72_RS00950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TX72_RS00960	COG2274	protein secretion by the type I secretion system
TX72_RS00970	COG0438	transferase activity, transferring glycosyl groups
TX72_RS00980	COG0124	histidyl-tRNA synthetase
TX72_RS00985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TX72_RS00990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TX72_RS01020	COG4447	cellulose binding
TX72_RS01025	COG1773	rubredoxin
TX72_RS01030	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX72_RS01035	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX72_RS01040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX72_RS01045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TX72_RS01060	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TX72_RS01060	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TX72_RS01075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TX72_RS01080	COG1132	(ABC) transporter
TX72_RS01085	COG0494	nUDIX hydrolase
TX72_RS01090	COG0415	Belongs to the DNA photolyase family
TX72_RS01120	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TX72_RS01125	COG0131	Imidazoleglycerol-phosphate dehydratase
TX72_RS01130	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
TX72_RS01140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TX72_RS01160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TX72_RS01165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TX72_RS01175	COG0354	folic acid binding
TX72_RS01180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TX72_RS01190	COG1253	flavin adenine dinucleotide binding
TX72_RS01195	COG0673	inositol 2-dehydrogenase activity
TX72_RS01215	COG0343	queuine tRNA-ribosyltransferase activity
TX72_RS01225	COG2205	protein histidine kinase activity
TX72_RS01240	COG0138	bifunctional purine biosynthesis protein purh
TX72_RS01255	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TX72_RS01260	COG0004	ammonium transporteR
TX72_RS01265	COG1489	DNA binding
TX72_RS01270	COG0728	peptidoglycan biosynthetic process
TX72_RS01295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TX72_RS01300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TX72_RS01305	COG1546	Belongs to the CinA family
TX72_RS01305	COG1058	Belongs to the CinA family
TX72_RS01310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TX72_RS01315	COG0066	3-isopropylmalate dehydratase activity
TX72_RS01350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TX72_RS01355	COG0193	aminoacyl-tRNA hydrolase activity
TX72_RS01370	COG4372	Transposase
TX72_RS01375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TX72_RS01380	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TX72_RS01390	COG0717	Belongs to the dCTP deaminase family
TX72_RS01400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TX72_RS01405	COG0739	heme binding
TX72_RS01405	COG0741	lytic transglycosylase activity
TX72_RS01405	COG1196	nuclear chromosome segregation
TX72_RS01410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TX72_RS01415	COG2971	BadF BadG BcrA BcrD
TX72_RS01425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TX72_RS01445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TX72_RS01465	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TX72_RS01470	COG1402	creatininase
TX72_RS01475	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TX72_RS01480	COG2094	Belongs to the DNA glycosylase MPG family
TX72_RS01485	COG0540	Belongs to the ATCase OTCase family
TX72_RS01515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TX72_RS01530	COG0529	Catalyzes the synthesis of activated sulfate
TX72_RS01530	COG2046	Belongs to the sulfate adenylyltransferase family
TX72_RS01535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TX72_RS01540	COG0800	Aldolase
TX72_RS01550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TX72_RS01580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TX72_RS01600	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
TX72_RS01605	COG0719	Fe-S assembly protein
TX72_RS01610	COG0396	ATPase activity
TX72_RS01615	COG0719	Fe-S assembly protein
TX72_RS01620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TX72_RS01630	COG0242	peptide deformylase activity
TX72_RS01650	COG0606	chelatase, subunit chli
TX72_RS01655	COG0537	adenosine 5'-monophosphoramidase activity
TX72_RS01660	COG4178	(ABC) transporter
TX72_RS01680	COG0515	serine threonine protein kinase
TX72_RS01695	COG0439	Biotin carboxylase
TX72_RS01705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TX72_RS01710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TX72_RS01725	COG1196	nuclear chromosome segregation
TX72_RS01750	COG0116	Belongs to the methyltransferase superfamily
TX72_RS01755	COG1525	nuclease
TX72_RS01765	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TX72_RS01990	COG2089	acid synthase
TX72_RS02010	COG1083	cytidylyl-transferase
TX72_RS02020	COG3562	capsule polysaccharide
TX72_RS02030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TX72_RS02045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TX72_RS02075	COG2274	protein secretion by the type I secretion system
TX72_RS02125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TX72_RS02130	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TX72_RS02135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TX72_RS02140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TX72_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
TX72_RS02180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TX72_RS02185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TX72_RS02190	COG2089	acid synthase
TX72_RS02195	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TX72_RS02200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TX72_RS02210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TX72_RS02220	COG0347	Belongs to the P(II) protein family
TX72_RS02225	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TX72_RS02270	COG1333	cytochrome c biogenesis protein
TX72_RS02290	COG0772	Belongs to the SEDS family
TX72_RS02350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TX72_RS02355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TX72_RS02365	COG0356	it plays a direct role in the translocation of protons across the membrane
TX72_RS02370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TX72_RS02375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TX72_RS02380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TX72_RS02385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TX72_RS02390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TX72_RS02395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TX72_RS02405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TX72_RS02415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TX72_RS02420	COG3012	SEC-C Motif Domain Protein
TX72_RS02430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TX72_RS02430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TX72_RS02435	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TX72_RS02440	COG1160	GTP binding
TX72_RS02445	COG1253	flavin adenine dinucleotide binding
TX72_RS02450	COG0006	proline dipeptidase activity
TX72_RS02470	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TX72_RS02475	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TX72_RS02480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TX72_RS02485	COG0459	protein refolding
TX72_RS02510	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TX72_RS02515	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TX72_RS02530	COG0443	Heat shock 70 kDa protein
TX72_RS02565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TX72_RS02585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TX72_RS02590	COG2264	protein methyltransferase activity
TX72_RS02605	COG2010	Cytochrome c
TX72_RS02610	COG1234	tRNA 3'-trailer cleavage
TX72_RS02615	COG2385	sporulation resulting in formation of a cellular spore
TX72_RS02620	COG0363	glucosamine-6-phosphate deaminase activity
TX72_RS02630	COG0217	transcriptional regulatory protein
TX72_RS02635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TX72_RS02645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TX72_RS02650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TX72_RS02660	COG4251	negative regulation of phosphorylation
TX72_RS02665	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TX72_RS02670	COG5002	protein histidine kinase activity
TX72_RS02675	COG0151	Belongs to the GarS family
TX72_RS02685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TX72_RS02695	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TX72_RS02700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TX72_RS02705	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TX72_RS02710	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TX72_RS02715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TX72_RS02730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TX72_RS02750	COG2197	response regulator
TX72_RS02760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TX72_RS02775	COG0284	orotidine-5'-phosphate decarboxylase activity
TX72_RS02810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TX72_RS02835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TX72_RS02840	COG2211	Major facilitator Superfamily
TX72_RS02860	COG0776	regulation of translation
TX72_RS02865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TX72_RS02885	COG1053	succinate dehydrogenase
TX72_RS02915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TX72_RS02930	COG0195	Participates in both transcription termination and antitermination
TX72_RS02935	COG0779	Required for maturation of 30S ribosomal subunits
TX72_RS02950	COG0641	radical SAM
TX72_RS02965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TX72_RS02970	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TX72_RS02975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TX72_RS02980	COG0268	Binds directly to 16S ribosomal RNA
TX72_RS02985	COG0084	hydrolase, TatD family'
TX72_RS02990	COG0085	RNA polymerase activity
TX72_RS02995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TX72_RS03000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TX72_RS03010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TX72_RS03055	COG0357	Ribosomal RNA small subunit methyltransferase G
TX72_RS03060	COG0484	heat shock protein binding
TX72_RS03070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TX72_RS03080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TX72_RS03100	COG0385	Bile acid
TX72_RS03105	COG4581	dead DEAH box helicase
TX72_RS03110	COG0114	fumarate hydratase activity
TX72_RS03140	COG0438	transferase activity, transferring glycosyl groups
TX72_RS03140	COG1216	Glycosyl transferase, family 2
TX72_RS03145	COG1088	dTDP-glucose 4,6-dehydratase activity
TX72_RS03175	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TX72_RS03185	COG1215	transferase activity, transferring glycosyl groups
TX72_RS03190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TX72_RS03200	COG1160	GTP binding
TX72_RS03205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TX72_RS03215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TX72_RS03220	COG1799	cell septum assembly
TX72_RS03225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TX72_RS03230	COG0438	transferase activity, transferring glycosyl groups
TX72_RS03240	COG1381	Involved in DNA repair and RecF pathway recombination
TX72_RS03245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TX72_RS03250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TX72_RS03255	COG0321	lipoyl(octanoyl) transferase activity
TX72_RS03260	COG1022	Amp-dependent synthetase and ligase
TX72_RS03270	COG0508	dehydrogenase complex catalyzes the overall conversion of
TX72_RS03275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TX72_RS03280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TX72_RS03310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TX72_RS03315	COG0440	acetolactate synthase activity
TX72_RS03320	COG2267	carboxylic ester hydrolase activity
TX72_RS03345	COG2226	methyltransferase
TX72_RS03355	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TX72_RS03360	COG0492	ferredoxin-NADP+ reductase activity
TX72_RS03410	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TX72_RS03415	COG0733	neurotransmitter:sodium symporter activity
TX72_RS03425	COG0215	cysteine-tRNA ligase activity
TX72_RS03430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TX72_RS03430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TX72_RS03435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TX72_RS03440	COG0012	GTP binding
TX72_RS03455	COG0601	transmembrane transport
TX72_RS03460	COG4533	DNA binding
TX72_RS03470	COG0460	homoserine dehydrogenase
TX72_RS03475	COG2166	iron-sulfur cluster assembly
TX72_RS03485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TX72_RS03490	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TX72_RS03495	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TX72_RS03510	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TX72_RS03515	COG2010	Cytochrome c
TX72_RS03520	COG0742	ribosomal rna small subunit methyltransferase
TX72_RS03525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TX72_RS03530	COG3118	belongs to the thioredoxin family
TX72_RS03535	COG0516	GMP reductase activity
TX72_RS03545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TX72_RS03550	COG0644	oxidoreductase
TX72_RS03555	COG1543	Belongs to the glycosyl hydrolase 57 family
TX72_RS03560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TX72_RS03565	COG0395	ABC-type sugar transport system, permease component
TX72_RS03585	COG0011	TIGRFAM Protein of
TX72_RS03595	COG0564	pseudouridine synthase activity
TX72_RS03600	COG4095	Psort location CytoplasmicMembrane, score
TX72_RS03605	COG1480	7TM receptor with intracellular HD hydrolase
TX72_RS03610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TX72_RS03620	COG0142	geranyltranstransferase activity
TX72_RS03630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TX72_RS03640	COG0406	alpha-ribazole phosphatase activity
TX72_RS03645	COG1254	Belongs to the acylphosphatase family
TX72_RS03650	COG1797	cobyrinic acid a,c-diamide synthase activity
TX72_RS03660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TX72_RS03680	COG2205	protein histidine kinase activity
TX72_RS03695	COG0308	aminopeptidase N
TX72_RS03745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TX72_RS03755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TX72_RS03780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TX72_RS03790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TX72_RS03800	COG2197	response regulator
TX72_RS03805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TX72_RS03820	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TX72_RS03835	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TX72_RS03840	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TX72_RS03845	COG0473	3-isopropylmalate dehydrogenase activity
TX72_RS03850	COG3954	Phosphoribulokinase
TX72_RS03860	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TX72_RS03865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TX72_RS03875	COG0673	inositol 2-dehydrogenase activity
TX72_RS03880	COG0191	fructose-bisphosphate aldolase activity
TX72_RS03885	COG1619	proteins homologs of microcin C7 resistance protein MccF
TX72_RS03890	COG0047	phosphoribosylformylglycinamidine synthase activity
TX72_RS03895	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TX72_RS03905	COG0668	transmembrane transport
TX72_RS03915	COG0640	Transcriptional regulator
TX72_RS03920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TX72_RS03970	COG5002	protein histidine kinase activity
TX72_RS04005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TX72_RS04020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TX72_RS04030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TX72_RS04035	COG1429	ligase activity, forming nitrogen-metal bonds
TX72_RS04045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TX72_RS04050	COG0149	triose-phosphate isomerase activity
TX72_RS04055	COG2501	S4 domain
TX72_RS04060	COG1132	(ABC) transporter
TX72_RS04075	COG1115	amino acid carrier protein
TX72_RS04085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TX72_RS04095	COG0799	negative regulation of ribosome biogenesis
TX72_RS04135	COG0659	secondary active sulfate transmembrane transporter activity
TX72_RS04140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TX72_RS04145	COG4597	amino acid ABC transporter
TX72_RS04150	COG0765	amino acid transport
TX72_RS04190	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TX72_RS04225	COG0625	glutathione transferase activity
TX72_RS04255	COG1799	cell septum assembly
TX72_RS04270	COG0735	belongs to the Fur family
TX72_RS04285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TX72_RS04320	COG0259	pyridoxamine-phosphate oxidase activity
TX72_RS04330	COG0123	including yeast histone deacetylase and acetoin utilization protein
TX72_RS04360	COG0786	glutamate:sodium symporter activity
TX72_RS04450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TX72_RS04460	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TX72_RS04485	COG0745	RESPONSE REGULATOR receiver
TX72_RS04495	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TX72_RS04500	COG0271	Belongs to the BolA IbaG family
TX72_RS04515	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TX72_RS04530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TX72_RS04535	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TX72_RS04555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TX72_RS04565	COG0513	Belongs to the DEAD box helicase family
TX72_RS04580	COG0724	RNA recognition motif
TX72_RS04585	COG1132	(ABC) transporter
TX72_RS04590	COG0475	glutathione-regulated potassium exporter activity
TX72_RS04590	COG0589	response to stress
TX72_RS04605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TX72_RS04610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TX72_RS04630	COG1054	Belongs to the UPF0176 family
TX72_RS04635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TX72_RS04640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TX72_RS04645	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TX72_RS04650	COG0019	diaminopimelate decarboxylase activity
TX72_RS04655	COG0456	acetyltransferase
TX72_RS04660	COG0542	response to heat
TX72_RS04665	COG0371	Dehydrogenase
TX72_RS04670	COG0596	Alpha beta hydrolase
TX72_RS04680	COG0575	Belongs to the CDS family
TX72_RS04685	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TX72_RS04690	COG1982	Orn Lys Arg decarboxylase major
TX72_RS04695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TX72_RS04705	COG0745	RESPONSE REGULATOR receiver
TX72_RS04710	COG5002	protein histidine kinase activity
TX72_RS04715	COG1187	pseudouridine synthase activity
TX72_RS04790	COG1640	4-alpha-glucanotransferase
TX72_RS04810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TX72_RS04825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TX72_RS04830	COG1121	(ABC) transporter
TX72_RS04855	COG0701	Predicted permease
TX72_RS04965	COG0681	Belongs to the peptidase S26 family
TX72_RS04970	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TX72_RS04975	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TX72_RS04980	COG1376	ErfK ybiS ycfS ynhG family protein
TX72_RS04985	COG0297	glycogen (starch) synthase activity
TX72_RS04995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TX72_RS05000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TX72_RS05010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TX72_RS05015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TX72_RS05020	COG2045	Belongs to the ComB family
TX72_RS05030	COG0860	N-Acetylmuramoyl-L-alanine amidase
TX72_RS05035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TX72_RS05040	COG0142	geranyltranstransferase activity
TX72_RS05045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TX72_RS05050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TX72_RS05060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TX72_RS05065	COG2176	DNA-directed DNA polymerase activity
TX72_RS05075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TX72_RS05080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TX72_RS05095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TX72_RS05105	COG1132	(ABC) transporter
TX72_RS05115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TX72_RS05120	COG0505	Belongs to the CarA family
TX72_RS05130	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
TX72_RS05135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TX72_RS05145	COG0154	amidase activity
TX72_RS05150	COG0587	DNA-directed DNA polymerase activity
TX72_RS05160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TX72_RS05165	COG0632	four-way junction helicase activity
TX72_RS05180	COG0358	DNA primase activity
TX72_RS05185	COG0798	PFAM Bile acid sodium symporter
TX72_RS05210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TX72_RS05225	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TX72_RS05240	COG0792	nuclease activity
TX72_RS05245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TX72_RS05250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TX72_RS05260	COG0022	dehydrogenase e1 component
TX72_RS05260	COG0508	dehydrogenase complex catalyzes the overall conversion of
TX72_RS05265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TX72_RS05270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TX72_RS05325	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TX72_RS05330	COG0515	serine threonine protein kinase
TX72_RS05360	COG0174	glutamine synthetase
TX72_RS05370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TX72_RS05390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TX72_RS05410	COG0612	Peptidase, M16
TX72_RS05435	COG1216	Glycosyl transferase, family 2
TX72_RS05440	COG0052	Belongs to the universal ribosomal protein uS2 family
TX72_RS05445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TX72_RS05455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TX72_RS05460	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TX72_RS05465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TX72_RS05470	COG0751	glycine-tRNA ligase activity
TX72_RS05480	COG0644	oxidoreductase
TX72_RS05490	COG0826	peptidase U32
TX72_RS05555	COG1217	gtp-binding protein TYPA
TX72_RS05580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TX72_RS05585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TX72_RS05590	COG1494	fructose-1,6-bisphosphatase
TX72_RS05595	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TX72_RS05600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TX72_RS05605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TX72_RS05610	COG0363	glucosamine-6-phosphate deaminase activity
TX72_RS05625	COG0129	dihydroxy-acid dehydratase activity
TX72_RS05635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TX72_RS05670	COG0300	oxidoreductase activity
TX72_RS05770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TX72_RS05775	COG4106	trans-aconitate 2-methyltransferase activity
TX72_RS05780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TX72_RS05800	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TX72_RS05825	COG1836	PFAM Integral membrane protein DUF92
TX72_RS05870	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TX72_RS05875	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TX72_RS05880	COG0436	Aminotransferase
TX72_RS05890	COG1573	uracil-dna glycosylase
TX72_RS05895	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TX72_RS05900	COG0793	Belongs to the peptidase S41A family
TX72_RS05905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TX72_RS05965	COG0861	Integral membrane protein TerC family
TX72_RS05980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TX72_RS05990	COG0312	modulator of DNA gyrase
TX72_RS05995	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
TX72_RS06010	COG0163	prenyltransferase activity
TX72_RS06015	COG0557	exoribonuclease II activity
TX72_RS06025	COG2119	membrane
TX72_RS06040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TX72_RS06040	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TX72_RS06060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TX72_RS06065	COG1615	UPF0182 protein
TX72_RS06070	COG0450	alkyl hydroperoxide reductase
TX72_RS06080	COG0739	heme binding
TX72_RS06085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TX72_RS06120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TX72_RS06125	COG0445	tRNA wobble uridine modification
TX72_RS06130	COG0557	exoribonuclease II activity
TX72_RS06135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TX72_RS06140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TX72_RS06145	COG0072	phenylalanine-tRNA ligase activity
TX72_RS06145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TX72_RS06150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TX72_RS06205	COG0646	methionine synthase
TX72_RS06205	COG1410	methionine synthase
TX72_RS06210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TX72_RS06230	COG1981	membrane
TX72_RS06235	COG3046	protein related to deoxyribodipyrimidine photolyase
TX72_RS06245	COG0322	excinuclease ABC activity
TX72_RS06255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TX72_RS06265	COG2027	D-alanyl-D-alanine carboxypeptidase
TX72_RS06285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TX72_RS06295	COG0495	leucyl-tRNA aminoacylation
TX72_RS06300	COG0166	Belongs to the GPI family
TX72_RS06325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TX72_RS06330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TX72_RS06335	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TX72_RS06335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TX72_RS06340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TX72_RS06345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TX72_RS06350	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TX72_RS06360	COG0484	heat shock protein binding
TX72_RS06365	COG0443	Heat shock 70 kDa protein
TX72_RS06370	COG0573	inorganic phosphate transmembrane transporter activity
TX72_RS06375	COG0581	inorganic phosphate transmembrane transporter activity
TX72_RS06380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TX72_RS06400	COG0633	Ferredoxin
TX72_RS06405	COG0483	inositol monophosphate 1-phosphatase activity
TX72_RS06410	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TX72_RS06420	COG0326	Molecular chaperone. Has ATPase activity
TX72_RS06425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TX72_RS06430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TX72_RS06435	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TX72_RS06440	COG1653	transport
TX72_RS06455	COG3842	ATPase activity
TX72_RS06460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TX72_RS06485	COG0644	oxidoreductase
TX72_RS06490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TX72_RS06495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TX72_RS06520	COG0469	pyruvate kinase activity
TX72_RS06525	COG0577	efflux transmembrane transporter activity
TX72_RS06525	COG1136	(ABC) transporter
TX72_RS06530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TX72_RS06540	COG0740	serine-type endopeptidase activity
TX72_RS06555	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TX72_RS06575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TX72_RS06580	COG1175	transmembrane transport
TX72_RS06585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TX72_RS06640	COG1793	dna ligase
TX72_RS06645	COG1201	RNA secondary structure unwinding
TX72_RS06650	COG2059	Chromate
TX72_RS06695	COG2226	methyltransferase
TX72_RS06730	COG1119	ATPase activity
TX72_RS06740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TX72_RS06755	COG1121	(ABC) transporter
TX72_RS06760	COG0803	Belongs to the bacterial solute-binding protein 9 family
TX72_RS06765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TX72_RS06770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TX72_RS06790	COG4974	Belongs to the 'phage' integrase family
TX72_RS06880	COG0724	RNA recognition motif
TX72_RS06955	COG2197	response regulator
TX72_RS06970	COG0189	ligase activity
TX72_RS06970	COG4067	protein conserved in archaea
TX72_RS06975	COG2197	response regulator
TX72_RS07020	COG0405	Gamma-glutamyltransferase
TX72_RS07100	COG2124	cytochrome p450
TX72_RS07120	COG0010	Belongs to the arginase family
TX72_RS07125	COG0375	protein maturation
TX72_RS07140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TX72_RS07145	COG1116	anion transmembrane transporter activity
TX72_RS07150	COG4638	Rieske (2fe-2S)
TX72_RS07170	COG2144	transferase activity, transferring acyl groups
TX72_RS07195	COG2072	flavoprotein involved in K transport
TX72_RS07260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TX72_RS07290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TX72_RS07410	COG0180	Tryptophanyl-tRNA synthetase
TX72_RS07425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TX72_RS07435	COG0837	glucose binding
TX72_RS07440	COG0083	homoserine kinase activity
TX72_RS07445	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX72_RS07450	COG0339	signal peptide processing
TX72_RS07465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TX72_RS07505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TX72_RS07510	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TX72_RS07520	COG3794	PFAM blue (type 1) copper domain protein
TX72_RS07550	COG0542	response to heat
TX72_RS07555	COG0720	synthase
TX72_RS07560	COG0140	phosphoribosyl-ATP diphosphatase activity
TX72_RS07560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TX72_RS07580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX72_RS07615	COG2010	Cytochrome c
TX72_RS07630	COG0159	tryptophan synthase activity
TX72_RS07655	COG0418	dihydroorotase activity
TX72_RS07660	COG0659	secondary active sulfate transmembrane transporter activity
TX72_RS07665	COG0530	calcium, potassium:sodium antiporter activity
TX72_RS07685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TX72_RS07690	COG1845	cytochrome c oxidase, subunit III
TX72_RS07705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TX72_RS07720	COG0037	tRNA processing
TX72_RS07725	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TX72_RS07730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TX72_RS07745	COG0456	acetyltransferase
TX72_RS07750	COG1132	(ABC) transporter
TX72_RS07755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TX72_RS07760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TX72_RS07765	COG3842	ATPase activity
TX72_RS07770	COG0251	oxidation-reduction process
TX72_RS07965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TX72_RS07985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TX72_RS07990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TX72_RS07995	COG2135	peptidase activity
TX72_RS08015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TX72_RS08015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TX72_RS08060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TX72_RS08065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TX72_RS08070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TX72_RS08080	COG0196	riboflavin kinase activity
TX72_RS08085	COG0352	thiamine-phosphate diphosphorylase activity
TX72_RS08100	COG1691	(AIR) carboxylase
TX72_RS08110	COG0336	Belongs to the RNA methyltransferase TrmD family
TX72_RS08125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TX72_RS08135	COG0670	Belongs to the BI1 family
TX72_RS08140	COG1702	phosphate starvation-inducible protein PhoH
TX72_RS08145	COG0228	four-way junction DNA binding
TX72_RS08150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TX72_RS08160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TX72_RS08165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX72_RS08170	COG0482	sulfurtransferase activity
TX72_RS08175	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TX72_RS08205	COG0134	indole-3-glycerol-phosphate synthase activity
TX72_RS08210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TX72_RS08215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TX72_RS08230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TX72_RS08235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TX72_RS08240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TX72_RS08245	COG0285	dihydrofolate synthase activity
TX72_RS08275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TX72_RS08280	COG1181	Belongs to the D-alanine--D-alanine ligase family
TX72_RS08295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TX72_RS08300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TX72_RS08305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TX72_RS08310	COG4956	integral membrane protein (PIN domain superfamily)
TX72_RS08315	COG0740	serine-type endopeptidase activity
TX72_RS08320	COG0740	serine-type endopeptidase activity
TX72_RS08325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TX72_RS08330	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TX72_RS08360	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TX72_RS08405	COG0582	viral genome integration into host DNA
TX72_RS08420	COG0752	glycyl-tRNA synthetase alpha subunit
TX72_RS08435	COG2226	methyltransferase
TX72_RS08440	COG0107	imidazoleglycerol-phosphate synthase activity
TX72_RS08450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TX72_RS08455	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TX72_RS08460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TX72_RS08460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TX72_RS08465	COG3695	enzyme binding
TX72_RS08470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TX72_RS08490	COG0481	GTPase activity
TX72_RS08500	COG0579	oxidoreductase
TX72_RS08505	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TX72_RS08520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TX72_RS08540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TX72_RS08545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TX72_RS08555	COG3239	Fatty acid desaturase
TX72_RS08580	COG0424	maF-like protein
TX72_RS08590	COG1492	cobalamin metabolic process
TX72_RS08620	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX72_RS08625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TX72_RS08630	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TX72_RS08655	COG4451	ribulose bisphosphate carboxylase, small
TX72_RS08660	COG1850	ribulose-bisphosphate carboxylase activity
TX72_RS08665	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TX72_RS08670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TX72_RS08675	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TX72_RS08685	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TX72_RS08690	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TX72_RS08695	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TX72_RS08720	COG0730	response to heat
TX72_RS08725	COG0095	Lipoate-protein ligase
TX72_RS08730	COG1994	Peptidase M50
TX72_RS08730	COG0517	IMP dehydrogenase activity
TX72_RS08735	COG0135	phosphoribosylanthranilate isomerase activity
TX72_RS08740	COG0302	gtp cyclohydrolase
TX72_RS08745	COG4221	oxidoreductase activity
TX72_RS08750	COG0825	malonyl-CoA metabolic process
TX72_RS08755	COG5322	oxidoreductase activity
TX72_RS08760	COG3396	Phenylacetate-CoA oxygenase
TX72_RS08770	COG0539	negative regulation of cytoplasmic translation
TX72_RS08780	COG1496	oxidoreductase activity
TX72_RS08785	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TX72_RS08805	COG0028	Belongs to the TPP enzyme family
TX72_RS08810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TX72_RS08820	COG2226	methyltransferase
TX72_RS08835	COG0528	UMP kinase activity
TX72_RS08840	COG0233	cytoplasmic translational termination
TX72_RS08855	COG0415	Belongs to the DNA photolyase family
TX72_RS08865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TX72_RS08870	COG0768	penicillin binding
TX72_RS08885	COG0588	phosphoglycerate mutase activity
TX72_RS08915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TX72_RS08925	COG0442	prolyl-tRNA aminoacylation
TX72_RS08935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TX72_RS08940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TX72_RS08955	COG0629	single-stranded DNA binding
TX72_RS08970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TX72_RS08980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TX72_RS08985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX72_RS08995	COG0181	hydroxymethylbilane synthase activity
TX72_RS09010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TX72_RS09015	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TX72_RS09030	COG0432	Pfam Uncharacterised protein family UPF0047
TX72_RS09035	COG2154	pterin-4-alpha-carbinolamine dehydratase
TX72_RS09040	COG0523	cobalamin synthesis protein
TX72_RS09045	COG1840	ABC-type Fe3 transport system, periplasmic component
TX72_RS09070	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TX72_RS09075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TX72_RS09095	COG0708	Exodeoxyribonuclease III
TX72_RS09100	COG0277	FAD linked oxidase domain protein
TX72_RS09105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TX72_RS09115	COG0295	cytidine deaminase activity
TX72_RS09125	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TX72_RS09135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TX72_RS09140	COG1666	GTP binding
TX72_RS09155	COG0857	belongs to the CobB CobQ family
TX72_RS09165	COG0300	oxidoreductase activity
TX72_RS09165	COG3000	fatty acid hydroxylase
TX72_RS09170	COG0024	Methionine aminopeptidase
TX72_RS09180	COG0335	large ribosomal subunit rRNA binding
TX72_RS09200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TX72_RS09220	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TX72_RS09230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TX72_RS09235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TX72_RS09250	COG0194	GDP metabolic process
TX72_RS09255	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TX72_RS09260	COG0805	protein transport
TX72_RS09270	COG0723	plastoquinol--plastocyanin reductase activity
TX72_RS09275	COG0739	heme binding
TX72_RS09280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TX72_RS09285	COG2875	Belongs to the precorrin methyltransferase family
TX72_RS09300	COG0248	Ppx GppA phosphatase
TX72_RS09305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TX72_RS09310	COG1619	proteins homologs of microcin C7 resistance protein MccF
TX72_RS09315	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TX72_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
TX72_RS09335	COG0459	protein refolding
TX72_RS09340	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
TX72_RS09360	COG0109	protoheme IX farnesyltransferase activity
TX72_RS09365	COG1612	heme a metabolic process
TX72_RS09370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TX72_RS09380	COG1845	cytochrome c oxidase, subunit III
TX72_RS09410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TX72_RS09425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TX72_RS09430	COG1007	ATP synthesis coupled electron transport
TX72_RS09435	COG0577	efflux transmembrane transporter activity
TX72_RS09435	COG1136	(ABC) transporter
TX72_RS09450	COG0436	Aminotransferase
TX72_RS09455	COG3118	belongs to the thioredoxin family
TX72_RS09460	COG1842	Phage shock protein A
TX72_RS09470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TX72_RS09480	COG0697	spore germination
TX72_RS09485	COG0616	signal peptide processing
TX72_RS09500	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TX72_RS09505	COG0594	ribonuclease P activity
TX72_RS09515	COG0706	membrane insertase activity
TX72_RS09525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TX72_RS09530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TX72_RS09535	COG0750	zinc metalloprotease
TX72_RS09540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TX72_RS09545	COG1185	polyribonucleotide nucleotidyltransferase activity
TX72_RS09555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TX72_RS09615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TX72_RS09620	COG2226	methyltransferase
TX72_RS09630	COG4176	ABC-type proline glycine betaine transport system permease component
TX72_RS09635	COG2113	Glycine betaine
TX72_RS09660	COG2988	succinylglutamate desuccinylase activity
TX72_RS09665	COG0435	Glutathione S-transferase
TX72_RS09675	COG0488	(ABC) transporter
TX72_RS09690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TX72_RS09695	COG3842	ATPase activity
TX72_RS09700	COG1193	negative regulation of DNA recombination
TX72_RS09710	COG0113	porphobilinogen synthase activity
TX72_RS09715	COG0484	heat shock protein binding
TX72_RS09720	COG4243	Vitamin k epoxide reductase
TX72_RS09725	COG0659	secondary active sulfate transmembrane transporter activity
TX72_RS09735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TX72_RS09785	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TX72_RS09790	COG1611	Belongs to the LOG family
TX72_RS09815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TX72_RS09820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TX72_RS09830	COG1012	belongs to the aldehyde dehydrogenase family
TX72_RS09835	COG1388	LysM domain
TX72_RS09835	COG0741	lytic transglycosylase activity
TX72_RS09855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TX72_RS09860	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TX72_RS09865	COG0235	Class ii aldolase
TX72_RS09870	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TX72_RS09905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TX72_RS09910	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TX72_RS09915	COG0793	Belongs to the peptidase S41A family
TX72_RS09920	COG1078	dGTPase activity
TX72_RS09925	COG0850	regulation of cytokinetic process
TX72_RS09930	COG2894	cell division
TX72_RS09935	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TX72_RS09945	COG0009	L-threonylcarbamoyladenylate synthase
TX72_RS09950	COG2890	protein-(glutamine-N5) methyltransferase activity
TX72_RS09955	COG0758	DNA mediated transformation
TX72_RS09955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TX72_RS09990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TX72_RS09995	COG0539	negative regulation of cytoplasmic translation
TX72_RS10000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TX72_RS10005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TX72_RS10010	COG1070	Carbohydrate kinase
TX72_RS10060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TX72_RS10165	COG1413	lyase activity
TX72_RS10170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TX72_RS10175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TX72_RS10175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TX72_RS10180	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TX72_RS10185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TX72_RS10195	COG4989	oxidoreductase activity
TX72_RS10220	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TX72_RS10240	COG0408	coproporphyrinogen oxidase activity
TX72_RS10245	COG0489	protein tyrosine kinase activity
TX72_RS10250	COG0772	Belongs to the SEDS family
TX72_RS10265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TX72_RS10275	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TX72_RS10290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TX72_RS10295	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TX72_RS10300	COG1606	tRNA processing
TX72_RS10305	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TX72_RS10325	COG3001	Fructosamine kinase
TX72_RS10330	COG1233	COG1233 Phytoene dehydrogenase and related
TX72_RS10355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TX72_RS10370	COG3854	ATPases associated with a variety of cellular activities
TX72_RS10385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TX72_RS10390	COG0088	Forms part of the polypeptide exit tunnel
TX72_RS10395	COG0089	rRNA binding
TX72_RS10400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TX72_RS10405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TX72_RS10410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TX72_RS10415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TX72_RS10420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TX72_RS10425	COG0255	Belongs to the universal ribosomal protein uL29 family
TX72_RS10430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TX72_RS10435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TX72_RS10440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TX72_RS10445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TX72_RS10450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TX72_RS10455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TX72_RS10460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TX72_RS10465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TX72_RS10470	COG0200	Binds to the 23S rRNA
TX72_RS10475	COG0201	protein transport
TX72_RS10480	COG0563	adenylate kinase activity
TX72_RS10485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TX72_RS10490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TX72_RS10495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TX72_RS10500	COG0202	RNA polymerase activity
TX72_RS10505	COG0203	ribosomal protein L17
TX72_RS10510	COG0101	tRNA pseudouridine synthase activity
TX72_RS10515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TX72_RS10520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TX72_RS10525	COG0254	rRNA binding
TX72_RS10530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TX72_RS10540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TX72_RS10550	COG0582	viral genome integration into host DNA
TX72_RS10595	COG0653	protein targeting
TX72_RS10615	COG1132	(ABC) transporter
TX72_RS10630	COG0463	Glycosyl transferase, family 2
TX72_RS10670	COG2885	chlorophyll binding
TX72_RS10675	COG2885	chlorophyll binding
TX72_RS10695	COG3659	wide pore channel activity
TX72_RS10710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TX72_RS10720	COG0069	glutamate synthase activity
TX72_RS10720	COG0067	glutamate synthase
TX72_RS10720	COG0070	glutamate synthase
TX72_RS10735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TX72_RS10740	COG0049	tRNA binding
TX72_RS10745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TX72_RS10750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TX72_RS10755	COG0051	transcription antitermination factor activity, RNA binding
TX72_RS10760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TX72_RS10765	COG2226	methyltransferase
TX72_RS10770	COG0077	Prephenate dehydratase
TX72_RS10770	COG1605	Chorismate mutase
TX72_RS10780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TX72_RS10785	COG1530	ribonuclease E activity
TX72_RS10795	COG0436	Aminotransferase
TX72_RS10800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TX72_RS10830	COG0033	Phosphoglucomutase
TX72_RS10840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TX72_RS10850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TX72_RS10865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TX72_RS10870	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TX72_RS10875	COG0175	sulfate reduction
TX72_RS10880	COG1252	NADH dehydrogenase
TX72_RS10885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TX72_RS10890	COG3273	potassium ion transport
TX72_RS10890	COG0471	metal ion transport
TX72_RS10895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TX72_RS10900	COG0569	domain protein
TX72_RS10905	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TX72_RS10930	COG0488	(ABC) transporter
TX72_RS10935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TX72_RS10950	COG1643	Atp-dependent helicase
TX72_RS10955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TX72_RS10965	COG1570	exodeoxyribonuclease VII activity
TX72_RS10970	COG1722	exodeoxyribonuclease VII activity
TX72_RS11030	COG1968	undecaprenyl-diphosphatase activity
TX72_RS11040	COG1555	photosystem II stabilization
TX72_RS11045	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TX72_RS11050	COG4243	Vitamin k epoxide reductase
TX72_RS11055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TX72_RS11070	COG1032	radical SAM domain protein
TX72_RS11100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TX72_RS11125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TX72_RS11130	COG1472	Belongs to the glycosyl hydrolase 3 family
TX72_RS11135	COG0463	Glycosyl transferase, family 2
TX72_RS11135	COG0457	Tetratricopeptide repeat
TX72_RS11140	COG1587	Uroporphyrinogen-III synthase
TX72_RS11155	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
TX72_RS11160	COG0316	Belongs to the HesB IscA family
TX72_RS11180	COG1090	epimerase
TX72_RS11200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TX72_RS11205	COG3659	wide pore channel activity
TX72_RS11210	COG3659	wide pore channel activity
TX72_RS11220	COG3659	wide pore channel activity
TX72_RS11260	COG1122	ATPase activity
TX72_RS11270	COG0745	RESPONSE REGULATOR receiver
TX72_RS11280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TX72_RS11285	COG2217	Heavy metal translocating P-type atpase
TX72_RS11290	COG3063	Type IV pilus biogenesis stability protein PilW
TX72_RS11325	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TX72_RS11335	COG0416	fatty acid biosynthetic process
TX72_RS11340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TX72_RS11345	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TX72_RS11360	COG1214	PFAM Peptidase M22, glycoprotease
TX72_RS11370	COG0617	tRNA 3'-terminal CCA addition
TX72_RS11375	COG0724	RNA recognition motif
TX72_RS11380	COG1562	ergosterol biosynthetic process
TX72_RS11385	COG0493	'glutamate synthase
TX72_RS11385	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
TX72_RS11400	COG0583	DNA-binding transcription factor activity
TX72_RS11410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TX72_RS11415	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX72_RS11430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TX72_RS11440	COG2197	response regulator
TX72_RS11450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TX72_RS11455	COG0713	ATP synthesis coupled electron transport
TX72_RS11460	COG0839	Belongs to the complex I subunit 6 family
TX72_RS11465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX72_RS11470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TX72_RS11475	COG0372	Belongs to the citrate synthase family
TX72_RS11480	COG2062	phosphohistidine phosphatase, SixA
TX72_RS11495	COG1420	regulation of RNA biosynthetic process
TX72_RS11500	COG0133	tryptophan synthase activity
TX72_RS11510	COG0023	Translation Initiation Factor
TX72_RS11515	COG0529	Catalyzes the synthesis of activated sulfate
TX72_RS11520	COG0628	permease
TX72_RS11525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TX72_RS11530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TX72_RS11535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TX72_RS11540	COG0564	pseudouridine synthase activity
TX72_RS11545	COG0745	RESPONSE REGULATOR receiver
TX72_RS11555	COG1104	cysteine desulfurase activity
TX72_RS11590	COG0649	NAD binding
TX72_RS11600	COG0824	Thioesterase
TX72_RS11650	COG1575	Belongs to the MenA family. Type 1 subfamily
TX72_RS11660	COG0189	ligase activity
TX72_RS11665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TX72_RS11670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TX72_RS11675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TX72_RS11680	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TX72_RS11685	COG0512	Glutamine amidotransferase of anthranilate synthase
TX72_RS11695	COG0252	asparaginase activity
TX72_RS11700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TX72_RS11705	COG0018	arginyl-trna synthetase
TX72_RS11710	COG0157	Belongs to the NadC ModD family
TX72_RS11720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TX72_RS11730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TX72_RS11735	COG4172	Belongs to the ABC transporter superfamily
TX72_RS11740	COG0564	pseudouridine synthase activity
TX72_RS11750	COG0589	response to stress
TX72_RS11755	COG0126	phosphoglycerate kinase activity
TX72_RS11775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TX72_RS11780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TX72_RS11800	COG0167	dihydroorotate dehydrogenase activity
TX72_RS11805	COG0328	RNA-DNA hybrid ribonuclease activity
TX72_RS11815	COG0222	ribosome binding
TX72_RS11820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TX72_RS11825	COG0081	regulation of translation
TX72_RS11830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TX72_RS11835	COG0250	Participates in transcription elongation, termination and antitermination
TX72_RS11840	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TX72_RS11845	COG0542	response to heat
TX72_RS11850	COG0346	lactoylglutathione lyase activity
TX72_RS11855	COG0148	phosphopyruvate hydratase activity
TX72_RS11860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TX72_RS11885	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TX72_RS11890	COG0237	dephospho-CoA kinase activity
TX72_RS11905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TX72_RS11910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TX72_RS11910	COG2022	thiamine diphosphate biosynthetic process
TX72_RS11915	COG0105	UTP biosynthetic process
TX72_RS11920	COG1166	arginine decarboxylase activity
TX72_RS11925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TX72_RS11935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TX72_RS11950	COG0071	Belongs to the small heat shock protein (HSP20) family
TX72_RS11960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TX72_RS11960	COG0426	domain, Protein
TX72_RS11965	COG0426	domain, Protein
TX72_RS11965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TX72_RS11975	COG1733	regulation of RNA biosynthetic process
TX72_RS11985	COG1741	Belongs to the pirin family
TX72_RS12000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TX72_RS12000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TX72_RS12005	COG0509	glycine decarboxylation via glycine cleavage system
TX72_RS12010	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TX72_RS12020	COG0359	binds to the 23S rRNA
TX72_RS12025	COG1372	Participates in initiation and elongation during chromosome replication
TX72_RS12025	COG0305	Participates in initiation and elongation during chromosome replication
TX72_RS12025	COG1372	Participates in initiation and elongation during chromosome replication
TX72_RS12025	COG0305	Participates in initiation and elongation during chromosome replication
TX72_RS12040	COG0445	tRNA wobble uridine modification
TX72_RS12075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TX72_RS12090	COG0398	Pfam SNARE associated Golgi protein
TX72_RS12110	COG0525	valine-tRNA ligase activity
TX72_RS12130	COG4221	oxidoreductase activity
TX72_RS12240	COG3956	TIGRFAM MazG family protein
TX72_RS12250	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TX72_RS12255	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TX72_RS12260	COG0010	Belongs to the arginase family
TX72_RS12275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TX72_RS12280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TX72_RS12290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX72_RS12295	COG0504	CTP synthase activity
TX72_RS12300	COG0602	queuosine metabolic process
TX72_RS12305	COG2084	Dehydrogenase
TX72_RS12310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TX72_RS12330	COG0366	Alpha amylase catalytic
TX72_RS12335	COG0463	Glycosyl transferase, family 2
TX72_RS12375	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TX72_RS12380	COG0830	nickel cation binding
TX72_RS12385	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TX72_RS12390	COG0829	nickel cation binding
TX72_RS12395	COG0831	urea catabolic process
TX72_RS12400	COG0832	Belongs to the urease beta subunit family
TX72_RS12405	COG0804	urea catabolic process
TX72_RS12420	COG0367	asparagine synthase
TX72_RS12425	COG0540	Belongs to the ATCase OTCase family
TX72_RS12435	COG2308	Evidence 4 Homologs of previously reported genes of
TX72_RS12455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TX72_RS12460	COG0746	molybdenum cofactor guanylyltransferase activity
TX72_RS12470	COG0243	molybdopterin cofactor binding
TX72_RS12490	COG0315	cyclic pyranopterin monophosphate synthase activity
TX72_RS12510	COG0314	molybdopterin synthase activity
TX72_RS12520	COG0521	Mo-molybdopterin cofactor biosynthetic process
TX72_RS12525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TX72_RS12540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TX72_RS12545	COG0523	cobalamin synthesis protein
TX72_RS12550	COG1116	anion transmembrane transporter activity
TX72_RS12555	COG1116	anion transmembrane transporter activity
TX72_RS12555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TX72_RS12560	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TX72_RS12570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TX72_RS12585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TX72_RS12590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX72_RS12595	COG0170	dolichyl monophosphate biosynthetic process
TX72_RS12605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TX72_RS12610	COG1049	propionate catabolic process, 2-methylcitrate cycle
TX72_RS12630	COG0788	formyltetrahydrofolate deformylase activity
TX72_RS12645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TX72_RS12650	COG0443	Heat shock 70 kDa protein
TX72_RS12655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TX72_RS12665	COG0360	Binds together with S18 to 16S ribosomal RNA
TX72_RS12675	COG0137	argininosuccinate synthase activity
TX72_RS12690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TX72_RS12700	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TX72_RS12705	COG0438	transferase activity, transferring glycosyl groups
TX72_RS12715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TX72_RS12720	COG0497	DNA recombination
TX72_RS12725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TX72_RS12735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TX72_RS12830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides