locus-tag	class	description
SYNGTI_RS00005	COG0142	geranyltranstransferase activity
SYNGTI_RS00010	COG1187	pseudouridine synthase activity
SYNGTI_RS00020	COG0515	serine threonine protein kinase
SYNGTI_RS00025	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYNGTI_RS00030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYNGTI_RS00035	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SYNGTI_RS00045	COG1166	arginine decarboxylase activity
SYNGTI_RS00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYNGTI_RS00060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SYNGTI_RS00065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SYNGTI_RS00070	COG1120	ATPase activity
SYNGTI_RS00075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYNGTI_RS00085	COG4977	sequence-specific DNA binding
SYNGTI_RS00110	COG2207	Transcriptional regulator
SYNGTI_RS00115	COG2226	methyltransferase
SYNGTI_RS00125	COG0848	biopolymer transport protein
SYNGTI_RS00130	COG0811	peptide transport
SYNGTI_RS00145	COG1132	(ABC) transporter
SYNGTI_RS00160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYNGTI_RS00165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYNGTI_RS00175	COG1132	(ABC) transporter
SYNGTI_RS00220	COG0409	Hydrogenase expression formation protein
SYNGTI_RS00225	COG1091	dTDP-4-dehydrorhamnose reductase activity
SYNGTI_RS00230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNGTI_RS00235	COG0297	glycogen (starch) synthase activity
SYNGTI_RS00250	COG1131	(ABC) transporter
SYNGTI_RS00265	COG2318	DinB family
SYNGTI_RS00270	COG4106	trans-aconitate 2-methyltransferase activity
SYNGTI_RS00285	COG1214	PFAM Peptidase M22, glycoprotease
SYNGTI_RS00305	COG1615	UPF0182 protein
SYNGTI_RS00320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SYNGTI_RS00325	COG0563	adenylate kinase activity
SYNGTI_RS00330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SYNGTI_RS00345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYNGTI_RS00360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYNGTI_RS00365	COG0194	GDP metabolic process
SYNGTI_RS00370	COG0406	alpha-ribazole phosphatase activity
SYNGTI_RS00380	COG0730	response to heat
SYNGTI_RS00385	COG1413	lyase activity
SYNGTI_RS00400	COG0330	HflC and HflK could
SYNGTI_RS00410	COG1530	ribonuclease E activity
SYNGTI_RS00415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SYNGTI_RS00420	COG0494	nUDIX hydrolase
SYNGTI_RS00425	COG1185	polyribonucleotide nucleotidyltransferase activity
SYNGTI_RS00430	COG0681	Belongs to the peptidase S26 family
SYNGTI_RS00445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SYNGTI_RS00455	COG1401	restriction endodeoxyribonuclease activity
SYNGTI_RS00460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SYNGTI_RS00465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SYNGTI_RS00510	COG1104	cysteine desulfurase activity
SYNGTI_RS00535	COG0582	viral genome integration into host DNA
SYNGTI_RS00545	COG2022	thiamine diphosphate biosynthetic process
SYNGTI_RS00545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNGTI_RS00560	COG5002	protein histidine kinase activity
SYNGTI_RS00570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYNGTI_RS00590	COG0704	Plays a role in the regulation of phosphate uptake
SYNGTI_RS00595	COG0779	Required for maturation of 30S ribosomal subunits
SYNGTI_RS00600	COG0195	Participates in both transcription termination and antitermination
SYNGTI_RS00610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYNGTI_RS00645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYNGTI_RS00655	COG0011	TIGRFAM Protein of
SYNGTI_RS00665	COG0589	response to stress
SYNGTI_RS00670	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYNGTI_RS00675	COG0010	Belongs to the arginase family
SYNGTI_RS00680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNGTI_RS00720	COG2099	Precorrin-6x reductase
SYNGTI_RS00735	COG1007	ATP synthesis coupled electron transport
SYNGTI_RS00750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYNGTI_RS00755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SYNGTI_RS00760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNGTI_RS00760	COG0426	domain, Protein
SYNGTI_RS00770	COG0426	domain, Protein
SYNGTI_RS00770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNGTI_RS00775	COG0793	Belongs to the peptidase S41A family
SYNGTI_RS00780	COG0009	L-threonylcarbamoyladenylate synthase
SYNGTI_RS00785	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SYNGTI_RS00790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SYNGTI_RS00795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYNGTI_RS00800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYNGTI_RS00805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYNGTI_RS00810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYNGTI_RS00815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYNGTI_RS00820	COG0356	it plays a direct role in the translocation of protons across the membrane
SYNGTI_RS00830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNGTI_RS00845	COG0714	Associated with various cellular activities
SYNGTI_RS00850	COG0316	Belongs to the HesB IscA family
SYNGTI_RS00855	COG0697	spore germination
SYNGTI_RS00865	COG1127	ABC transporter
SYNGTI_RS00875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SYNGTI_RS00900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYNGTI_RS00915	COG0163	prenyltransferase activity
SYNGTI_RS00925	COG0589	response to stress
SYNGTI_RS00935	COG5001	Diguanylate cyclase
SYNGTI_RS00935	COG1716	ATPase activity
SYNGTI_RS00945	COG1217	gtp-binding protein TYPA
SYNGTI_RS00960	COG1234	tRNA 3'-trailer cleavage
SYNGTI_RS00970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SYNGTI_RS00985	COG0631	protein serine/threonine phosphatase activity
SYNGTI_RS00990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYNGTI_RS01000	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
SYNGTI_RS01005	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNGTI_RS01010	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNGTI_RS01015	COG0493	'glutamate synthase
SYNGTI_RS01060	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNGTI_RS01060	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNGTI_RS01075	COG1982	Orn Lys Arg decarboxylase major
SYNGTI_RS01080	COG0686	Belongs to the AlaDH PNT family
SYNGTI_RS01085	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SYNGTI_RS01105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNGTI_RS01115	COG0673	inositol 2-dehydrogenase activity
SYNGTI_RS01120	COG0700	Nucleoside recognition
SYNGTI_RS01125	COG2715	membrane protein required for spore maturation
SYNGTI_RS01130	COG1640	4-alpha-glucanotransferase
SYNGTI_RS01140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SYNGTI_RS01155	COG2203	Gaf domain
SYNGTI_RS01155	COG3706	GGDEF domain
SYNGTI_RS01155	COG5001	Diguanylate cyclase
SYNGTI_RS01155	COG4251	negative regulation of phosphorylation
SYNGTI_RS01160	COG2205	protein histidine kinase activity
SYNGTI_RS01160	COG0784	Response regulator, receiver
SYNGTI_RS01170	COG1981	membrane
SYNGTI_RS01175	COG0175	sulfate reduction
SYNGTI_RS01180	COG1420	regulation of RNA biosynthetic process
SYNGTI_RS01190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SYNGTI_RS01195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SYNGTI_RS01205	COG0003	Pfam Anion-transporting ATPase
SYNGTI_RS01210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNGTI_RS01225	COG0484	heat shock protein binding
SYNGTI_RS01230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYNGTI_RS01240	COG1216	Glycosyl transferase, family 2
SYNGTI_RS01240	COG0463	Glycosyl transferase, family 2
SYNGTI_RS01250	COG1605	Chorismate mutase
SYNGTI_RS01250	COG0077	Prephenate dehydratase
SYNGTI_RS01260	COG3706	GGDEF domain
SYNGTI_RS01260	COG5001	Diguanylate cyclase
SYNGTI_RS01260	COG2203	Gaf domain
SYNGTI_RS01260	COG4251	negative regulation of phosphorylation
SYNGTI_RS01275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYNGTI_RS01305	COG0589	response to stress
SYNGTI_RS01310	COG2226	methyltransferase
SYNGTI_RS01325	COG0538	isocitrate dehydrogenase activity
SYNGTI_RS01330	COG4636	protein conserved in cyanobacteria
SYNGTI_RS01340	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_RS01355	COG0762	integral membrane protein
SYNGTI_RS01360	COG1840	ABC-type Fe3 transport system, periplasmic component
SYNGTI_RS01365	COG0336	Belongs to the RNA methyltransferase TrmD family
SYNGTI_RS01370	COG0205	6-phosphofructokinase activity
SYNGTI_RS01375	COG1289	transmembrane transporter activity
SYNGTI_RS01380	COG1555	photosystem II stabilization
SYNGTI_RS01390	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SYNGTI_RS01395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SYNGTI_RS01400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SYNGTI_RS01425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SYNGTI_RS01430	COG0277	FAD linked oxidase domain protein
SYNGTI_RS01450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SYNGTI_RS01460	COG0408	coproporphyrinogen oxidase activity
SYNGTI_RS01465	COG5398	heme oxygenase
SYNGTI_RS01475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SYNGTI_RS01495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYNGTI_RS01500	COG0672	)-iron permease
SYNGTI_RS01505	COG0592	DNA-directed DNA polymerase activity
SYNGTI_RS01510	COG0159	tryptophan synthase activity
SYNGTI_RS01525	COG0436	Aminotransferase
SYNGTI_RS01535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SYNGTI_RS01550	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SYNGTI_RS01560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SYNGTI_RS01565	COG0701	Predicted permease
SYNGTI_RS01585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SYNGTI_RS01590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYNGTI_RS01595	COG4636	protein conserved in cyanobacteria
SYNGTI_RS01600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SYNGTI_RS01620	COG3206	protein involved in exopolysaccharide biosynthesis
SYNGTI_RS01620	COG0489	protein tyrosine kinase activity
SYNGTI_RS01660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYNGTI_RS01700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYNGTI_RS01705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYNGTI_RS01710	COG1088	dTDP-glucose 4,6-dehydratase activity
SYNGTI_RS01715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNGTI_RS01735	COG1215	transferase activity, transferring glycosyl groups
SYNGTI_RS01745	COG1215	transferase activity, transferring glycosyl groups
SYNGTI_RS01750	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_RS01775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNGTI_RS01800	COG0297	glycogen (starch) synthase activity
SYNGTI_RS01805	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_RS01810	COG1598	PFAM Uncharacterised protein family UPF0150
SYNGTI_RS01820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNGTI_RS01855	COG0110	maltose O-acetyltransferase activity
SYNGTI_RS01870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNGTI_RS01880	COG3781	membrane
SYNGTI_RS01885	COG0045	succinate-CoA ligase (ADP-forming) activity
SYNGTI_RS01890	COG0861	Integral membrane protein TerC family
SYNGTI_RS01895	COG2268	Band 7 protein
SYNGTI_RS01900	COG0463	Glycosyl transferase, family 2
SYNGTI_RS01905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYNGTI_RS01915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYNGTI_RS01920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SYNGTI_RS01925	COG0004	ammonium transporteR
SYNGTI_RS01930	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS01945	COG0737	Belongs to the 5'-nucleotidase family
SYNGTI_RS01955	COG0529	Catalyzes the synthesis of activated sulfate
SYNGTI_RS01960	COG0811	peptide transport
SYNGTI_RS01965	COG0848	biopolymer transport protein
SYNGTI_RS01970	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SYNGTI_RS01970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYNGTI_RS01980	COG0530	calcium, potassium:sodium antiporter activity
SYNGTI_RS01985	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SYNGTI_RS02000	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS02005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYNGTI_RS02010	COG1234	tRNA 3'-trailer cleavage
SYNGTI_RS02035	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SYNGTI_RS02040	COG2203	Gaf domain
SYNGTI_RS02040	COG3706	GGDEF domain
SYNGTI_RS02040	COG4251	negative regulation of phosphorylation
SYNGTI_RS02040	COG5001	Diguanylate cyclase
SYNGTI_RS02050	COG0471	metal ion transport
SYNGTI_RS02050	COG3273	potassium ion transport
SYNGTI_RS02080	COG3854	ATPases associated with a variety of cellular activities
SYNGTI_RS02085	COG0352	thiamine-phosphate diphosphorylase activity
SYNGTI_RS02090	COG0434	BtpA family
SYNGTI_RS02115	COG0564	pseudouridine synthase activity
SYNGTI_RS02120	COG3706	GGDEF domain
SYNGTI_RS02120	COG5001	Diguanylate cyclase
SYNGTI_RS02120	COG4251	negative regulation of phosphorylation
SYNGTI_RS02120	COG2203	Gaf domain
SYNGTI_RS02130	COG0475	glutathione-regulated potassium exporter activity
SYNGTI_RS02165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYNGTI_RS02170	COG1733	regulation of RNA biosynthetic process
SYNGTI_RS02175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYNGTI_RS02215	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SYNGTI_RS02230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNGTI_RS02240	COG1487	ribonuclease activity
SYNGTI_RS02260	COG2361	Protein of unknown function DUF86
SYNGTI_RS02275	COG0067	glutamate synthase
SYNGTI_RS02275	COG0069	glutamate synthase activity
SYNGTI_RS02275	COG0070	glutamate synthase
SYNGTI_RS02290	COG2133	pyrroloquinoline quinone binding
SYNGTI_RS02295	COG1797	cobyrinic acid a,c-diamide synthase activity
SYNGTI_RS02300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SYNGTI_RS02305	COG1022	Amp-dependent synthetase and ligase
SYNGTI_RS02310	COG0784	Response regulator, receiver
SYNGTI_RS02325	COG2203	Gaf domain
SYNGTI_RS02325	COG0840	transmembrane signaling receptor activity
SYNGTI_RS02330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYNGTI_RS02335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYNGTI_RS02340	COG3706	GGDEF domain
SYNGTI_RS02340	COG2203	Gaf domain
SYNGTI_RS02340	COG5001	Diguanylate cyclase
SYNGTI_RS02340	COG4251	negative regulation of phosphorylation
SYNGTI_RS02345	COG0419	ATPase involved in DNA repair
SYNGTI_RS02350	COG0484	heat shock protein binding
SYNGTI_RS02355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SYNGTI_RS02365	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SYNGTI_RS02390	COG1429	ligase activity, forming nitrogen-metal bonds
SYNGTI_RS02405	COG3956	TIGRFAM MazG family protein
SYNGTI_RS02415	COG5002	protein histidine kinase activity
SYNGTI_RS02425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYNGTI_RS02440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SYNGTI_RS02445	COG1247	-acetyltransferase
SYNGTI_RS02450	COG0174	glutamine synthetase
SYNGTI_RS02460	COG5001	Diguanylate cyclase
SYNGTI_RS02460	COG2203	Gaf domain
SYNGTI_RS02460	COG4251	negative regulation of phosphorylation
SYNGTI_RS02460	COG3706	GGDEF domain
SYNGTI_RS02470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SYNGTI_RS02475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SYNGTI_RS02490	COG2310	stress, protein
SYNGTI_RS02495	COG0076	glutamate decarboxylase activity
SYNGTI_RS02510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNGTI_RS02515	COG0829	nickel cation binding
SYNGTI_RS02530	COG1045	serine acetyltransferase
SYNGTI_RS02545	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SYNGTI_RS02560	COG0271	Belongs to the BolA IbaG family
SYNGTI_RS02565	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SYNGTI_RS02570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SYNGTI_RS02575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SYNGTI_RS02580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYNGTI_RS02590	COG0804	urea catabolic process
SYNGTI_RS02605	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_RS02625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SYNGTI_RS02630	COG1773	rubredoxin
SYNGTI_RS02635	COG4447	cellulose binding
SYNGTI_RS02660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SYNGTI_RS02670	COG3385	transposase activity
SYNGTI_RS02690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYNGTI_RS02700	COG3228	Belongs to the MtfA family
SYNGTI_RS02735	COG1121	(ABC) transporter
SYNGTI_RS02740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYNGTI_RS02755	COG1702	phosphate starvation-inducible protein PhoH
SYNGTI_RS02770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNGTI_RS02790	COG0484	heat shock protein binding
SYNGTI_RS02795	COG0443	Heat shock 70 kDa protein
SYNGTI_RS02800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SYNGTI_RS02830	COG3659	wide pore channel activity
SYNGTI_RS02840	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYNGTI_RS02840	COG2247	cell wall binding repeat
SYNGTI_RS02900	COG0768	penicillin binding
SYNGTI_RS02910	COG0247	lactate metabolic process
SYNGTI_RS02920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNGTI_RS02930	COG0583	DNA-binding transcription factor activity
SYNGTI_RS02940	COG0384	phenazine biosynthesis protein PhzF
SYNGTI_RS02955	COG2319	Wd-40 repeat
SYNGTI_RS02960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNGTI_RS02985	COG0475	glutathione-regulated potassium exporter activity
SYNGTI_RS02985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SYNGTI_RS02990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYNGTI_RS03010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SYNGTI_RS03015	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SYNGTI_RS03030	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNGTI_RS03035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYNGTI_RS03050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYNGTI_RS03055	COG0629	single-stranded DNA binding
SYNGTI_RS03070	COG0668	transmembrane transport
SYNGTI_RS03080	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS03085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNGTI_RS03085	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SYNGTI_RS03090	COG3937	granule-associated protein
SYNGTI_RS03105	COG2226	methyltransferase
SYNGTI_RS03115	COG0681	Belongs to the peptidase S26 family
SYNGTI_RS03125	COG1271	oxidase subunit
SYNGTI_RS03130	COG1294	oxidase, subunit
SYNGTI_RS03135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SYNGTI_RS03140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SYNGTI_RS03145	COG0412	Dienelactone hydrolase
SYNGTI_RS03190	COG2198	Histidine kinase
SYNGTI_RS03190	COG0784	Response regulator, receiver
SYNGTI_RS03190	COG0643	Histidine kinase
SYNGTI_RS03195	COG0840	transmembrane signaling receptor activity
SYNGTI_RS03195	COG2203	Gaf domain
SYNGTI_RS03210	COG0784	Response regulator, receiver
SYNGTI_RS03215	COG0557	exoribonuclease II activity
SYNGTI_RS03225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNGTI_RS03240	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SYNGTI_RS03250	COG5002	protein histidine kinase activity
SYNGTI_RS03255	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
SYNGTI_RS03265	COG1309	transcriptional regulator
SYNGTI_RS03290	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYNGTI_RS03300	COG2385	sporulation resulting in formation of a cellular spore
SYNGTI_RS03310	COG3411	Ferredoxin
SYNGTI_RS03315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYNGTI_RS03340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SYNGTI_RS03345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SYNGTI_RS03350	COG0237	dephospho-CoA kinase activity
SYNGTI_RS03355	COG0237	dephospho-CoA kinase activity
SYNGTI_RS03385	COG0515	serine threonine protein kinase
SYNGTI_RS03390	COG0515	serine threonine protein kinase
SYNGTI_RS03400	COG2988	succinylglutamate desuccinylase activity
SYNGTI_RS03405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYNGTI_RS03415	COG0739	heme binding
SYNGTI_RS03420	COG0587	DNA-directed DNA polymerase activity
SYNGTI_RS03435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYNGTI_RS03465	COG1006	Multisubunit Na H antiporter MnhC subunit
SYNGTI_RS03470	COG0651	ATP synthesis coupled electron transport
SYNGTI_RS03475	COG1006	Multisubunit Na H antiporter MnhC subunit
SYNGTI_RS03540	COG1132	(ABC) transporter
SYNGTI_RS03545	COG3063	Type IV pilus biogenesis stability protein PilW
SYNGTI_RS03550	COG2217	Heavy metal translocating P-type atpase
SYNGTI_RS03555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SYNGTI_RS03560	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS03570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYNGTI_RS03575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SYNGTI_RS03585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SYNGTI_RS03615	COG0557	exoribonuclease II activity
SYNGTI_RS03625	COG2208	phosphoserine phosphatase activity
SYNGTI_RS03635	COG0165	Argininosuccinate lyase
SYNGTI_RS03640	COG2816	NAD+ diphosphatase activity
SYNGTI_RS03655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SYNGTI_RS03660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SYNGTI_RS03665	COG1845	cytochrome c oxidase, subunit III
SYNGTI_RS03670	COG3118	belongs to the thioredoxin family
SYNGTI_RS03680	COG1116	anion transmembrane transporter activity
SYNGTI_RS03685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYNGTI_RS03700	COG0375	protein maturation
SYNGTI_RS03705	COG0010	Belongs to the arginase family
SYNGTI_RS03720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYNGTI_RS03730	COG0495	leucyl-tRNA aminoacylation
SYNGTI_RS03735	COG0786	glutamate:sodium symporter activity
SYNGTI_RS03745	COG2205	protein histidine kinase activity
SYNGTI_RS03755	COG1132	(ABC) transporter
SYNGTI_RS03775	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SYNGTI_RS03780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYNGTI_RS03785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYNGTI_RS03810	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SYNGTI_RS03815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SYNGTI_RS03825	COG0254	rRNA binding
SYNGTI_RS03830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SYNGTI_RS03835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SYNGTI_RS03840	COG0101	tRNA pseudouridine synthase activity
SYNGTI_RS03845	COG0203	ribosomal protein L17
SYNGTI_RS03850	COG0202	RNA polymerase activity
SYNGTI_RS03855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SYNGTI_RS03860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SYNGTI_RS03865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SYNGTI_RS03870	COG0563	adenylate kinase activity
SYNGTI_RS03875	COG0201	protein transport
SYNGTI_RS03880	COG0200	Binds to the 23S rRNA
SYNGTI_RS03885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SYNGTI_RS03890	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SYNGTI_RS03895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SYNGTI_RS03900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SYNGTI_RS03905	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SYNGTI_RS03910	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SYNGTI_RS03915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SYNGTI_RS03920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SYNGTI_RS03925	COG0255	Belongs to the universal ribosomal protein uL29 family
SYNGTI_RS03930	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SYNGTI_RS03935	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SYNGTI_RS03940	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SYNGTI_RS03945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SYNGTI_RS03950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SYNGTI_RS03955	COG0089	rRNA binding
SYNGTI_RS03960	COG0088	Forms part of the polypeptide exit tunnel
SYNGTI_RS03965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SYNGTI_RS03970	COG0783	Belongs to the Dps family
SYNGTI_RS03990	COG2010	Cytochrome c
SYNGTI_RS04000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SYNGTI_RS04005	COG0830	nickel cation binding
SYNGTI_RS04015	COG1131	(ABC) transporter
SYNGTI_RS04035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYNGTI_RS04040	COG0085	RNA polymerase activity
SYNGTI_RS04045	COG0084	hydrolase, TatD family'
SYNGTI_RS04050	COG0268	Binds directly to 16S ribosomal RNA
SYNGTI_RS04055	COG5002	protein histidine kinase activity
SYNGTI_RS04065	COG0210	DNA helicase
SYNGTI_RS04065	COG0210	DNA helicase
SYNGTI_RS04070	COG1196	nuclear chromosome segregation
SYNGTI_RS04075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SYNGTI_RS04095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYNGTI_RS04095	COG0758	DNA mediated transformation
SYNGTI_RS04100	COG0393	Putative heavy-metal-binding
SYNGTI_RS04110	COG0450	alkyl hydroperoxide reductase
SYNGTI_RS04115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SYNGTI_RS04130	COG1175	transmembrane transport
SYNGTI_RS04140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNGTI_RS04165	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_RS04165	COG3347	Dehydrogenase
SYNGTI_RS04185	COG3706	GGDEF domain
SYNGTI_RS04185	COG5001	Diguanylate cyclase
SYNGTI_RS04185	COG4251	negative regulation of phosphorylation
SYNGTI_RS04185	COG2203	Gaf domain
SYNGTI_RS04190	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS04195	COG0784	Response regulator, receiver
SYNGTI_RS04205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SYNGTI_RS04215	COG2239	Acts as a magnesium transporter
SYNGTI_RS04245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SYNGTI_RS04250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SYNGTI_RS04255	COG1799	cell septum assembly
SYNGTI_RS04260	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SYNGTI_RS04260	COG0662	Cupin 2, conserved barrel domain protein
SYNGTI_RS04275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYNGTI_RS04280	COG0459	protein refolding
SYNGTI_RS04300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SYNGTI_RS04305	COG0222	ribosome binding
SYNGTI_RS04310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SYNGTI_RS04315	COG0081	regulation of translation
SYNGTI_RS04320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SYNGTI_RS04325	COG0250	Participates in transcription elongation, termination and antitermination
SYNGTI_RS04330	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SYNGTI_RS04340	COG0335	large ribosomal subunit rRNA binding
SYNGTI_RS04370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYNGTI_RS04380	COG3243	poly(R)-hydroxyalkanoic acid synthase
SYNGTI_RS04390	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SYNGTI_RS04400	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_RS04405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYNGTI_RS04415	COG2885	chlorophyll binding
SYNGTI_RS04420	COG2885	chlorophyll binding
SYNGTI_RS04430	COG1132	(ABC) transporter
SYNGTI_RS04440	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_RS04450	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS04455	COG0022	dehydrogenase e1 component
SYNGTI_RS04455	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYNGTI_RS04460	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNGTI_RS04465	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNGTI_RS04470	COG1929	Belongs to the glycerate kinase type-1 family
SYNGTI_RS04475	COG3659	wide pore channel activity
SYNGTI_RS04480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYNGTI_RS04485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SYNGTI_RS04490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SYNGTI_RS04520	COG0776	regulation of translation
SYNGTI_RS04535	COG0514	ATP-dependent DNA helicase (RecQ)
SYNGTI_RS04545	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SYNGTI_RS04550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYNGTI_RS04560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SYNGTI_RS04610	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_RS04615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYNGTI_RS04620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SYNGTI_RS04625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNGTI_RS04640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYNGTI_RS04645	COG0242	peptide deformylase activity
SYNGTI_RS04655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SYNGTI_RS04685	COG0243	molybdopterin cofactor binding
SYNGTI_RS04695	COG1116	anion transmembrane transporter activity
SYNGTI_RS04700	COG1116	anion transmembrane transporter activity
SYNGTI_RS04700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYNGTI_RS04705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYNGTI_RS04710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYNGTI_RS04715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYNGTI_RS04725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SYNGTI_RS04730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SYNGTI_RS04740	COG0793	Belongs to the peptidase S41A family
SYNGTI_RS04750	COG0275	rRNA processing
SYNGTI_RS04760	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SYNGTI_RS04790	COG1090	epimerase
SYNGTI_RS04795	COG3842	ATPase activity
SYNGTI_RS04800	COG0515	serine threonine protein kinase
SYNGTI_RS04810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SYNGTI_RS04815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SYNGTI_RS04820	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SYNGTI_RS04825	COG0659	secondary active sulfate transmembrane transporter activity
SYNGTI_RS04830	COG0589	response to stress
SYNGTI_RS04835	COG1233	COG1233 Phytoene dehydrogenase and related
SYNGTI_RS04850	COG1053	succinate dehydrogenase
SYNGTI_RS04855	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYNGTI_RS04860	COG0537	adenosine 5'-monophosphoramidase activity
SYNGTI_RS04890	COG0402	S-adenosylhomocysteine deaminase activity
SYNGTI_RS04905	COG2267	carboxylic ester hydrolase activity
SYNGTI_RS04915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SYNGTI_RS04920	COG0189	ligase activity
SYNGTI_RS04930	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SYNGTI_RS04935	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SYNGTI_RS04960	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SYNGTI_RS04965	COG0312	modulator of DNA gyrase
SYNGTI_RS04985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SYNGTI_RS04995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYNGTI_RS04995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYNGTI_RS05010	COG2140	Oxalate decarboxylase
SYNGTI_RS05015	COG0058	SHG alpha-glucan phosphorylase activity
SYNGTI_RS05040	COG0515	serine threonine protein kinase
SYNGTI_RS05060	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYNGTI_RS05060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYNGTI_RS05065	COG3850	Histidine kinase
SYNGTI_RS05065	COG4999	Histidine kinase
SYNGTI_RS05065	COG3437	response regulator, receiver
SYNGTI_RS05065	COG2205	protein histidine kinase activity
SYNGTI_RS05095	COG0546	phosphoglycolate phosphatase activity
SYNGTI_RS05100	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SYNGTI_RS05105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SYNGTI_RS05135	COG0539	negative regulation of cytoplasmic translation
SYNGTI_RS05150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SYNGTI_RS05155	COG1132	(ABC) transporter
SYNGTI_RS05160	COG0469	pyruvate kinase activity
SYNGTI_RS05180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYNGTI_RS05185	COG1268	BioY protein
SYNGTI_RS05190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SYNGTI_RS05210	COG3659	wide pore channel activity
SYNGTI_RS05215	COG0765	amino acid transport
SYNGTI_RS05225	COG0058	SHG alpha-glucan phosphorylase activity
SYNGTI_RS05235	COG0575	Belongs to the CDS family
SYNGTI_RS05260	COG1970	mechanosensitive ion channel activity
SYNGTI_RS05265	COG0632	four-way junction helicase activity
SYNGTI_RS05270	COG1836	PFAM Integral membrane protein DUF92
SYNGTI_RS05275	COG0446	pyridine nucleotide-disulphide oxidoreductase
SYNGTI_RS05280	COG0724	RNA recognition motif
SYNGTI_RS05285	COG0154	amidase activity
SYNGTI_RS05290	COG0739	heme binding
SYNGTI_RS05295	COG0509	glycine decarboxylation via glycine cleavage system
SYNGTI_RS05310	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNGTI_RS05330	COG1316	TRANSCRIPTIONal
SYNGTI_RS05345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYNGTI_RS05355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SYNGTI_RS05360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYNGTI_RS05370	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_RS05385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNGTI_RS05400	COG0322	excinuclease ABC activity
SYNGTI_RS05425	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SYNGTI_RS05435	COG3258	Cytochrome c
SYNGTI_RS05440	COG0723	plastoquinol--plastocyanin reductase activity
SYNGTI_RS05460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SYNGTI_RS05485	COG2319	Wd-40 repeat
SYNGTI_RS05490	COG2319	Wd-40 repeat
SYNGTI_RS05510	COG1082	Xylose isomerase domain protein TIM barrel
SYNGTI_RS05525	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SYNGTI_RS05550	COG1366	Belongs to the anti-sigma-factor antagonist family
SYNGTI_RS05565	COG2208	phosphoserine phosphatase activity
SYNGTI_RS05565	COG2770	Histidine kinase
SYNGTI_RS05595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYNGTI_RS05600	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SYNGTI_RS05640	COG1741	Belongs to the pirin family
SYNGTI_RS05650	COG1193	negative regulation of DNA recombination
SYNGTI_RS05655	COG0631	protein serine/threonine phosphatase activity
SYNGTI_RS05660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNGTI_RS05670	COG3937	granule-associated protein
SYNGTI_RS05685	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYNGTI_RS05690	COG3932	Exopolysaccharide synthesis, ExoD
SYNGTI_RS05695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYNGTI_RS05705	COG0360	Binds together with S18 to 16S ribosomal RNA
SYNGTI_RS05710	COG0179	Fumarylacetoacetate (FAA) hydrolase
SYNGTI_RS05715	COG1413	lyase activity
SYNGTI_RS05720	COG0641	radical SAM
SYNGTI_RS05755	COG0083	homoserine kinase activity
SYNGTI_RS05765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYNGTI_RS05770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_RS05780	COG0196	riboflavin kinase activity
SYNGTI_RS05800	COG0180	Tryptophanyl-tRNA synthetase
SYNGTI_RS05805	COG1713	HD superfamily hydrolase involved in NAD metabolism
SYNGTI_RS05810	COG0799	negative regulation of ribosome biogenesis
SYNGTI_RS05820	COG0181	hydroxymethylbilane synthase activity
SYNGTI_RS05825	COG0427	acetyl-CoA hydrolase
SYNGTI_RS05830	COG0857	belongs to the CobB CobQ family
SYNGTI_RS05830	COG0280	phosphate acetyltransferase
SYNGTI_RS05840	COG1489	DNA binding
SYNGTI_RS05850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNGTI_RS05860	COG0602	queuosine metabolic process
SYNGTI_RS05865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SYNGTI_RS05870	COG0612	Peptidase, M16
SYNGTI_RS05875	COG0612	Peptidase, M16
SYNGTI_RS05885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SYNGTI_RS05895	COG0187	DNA topoisomerase II activity
SYNGTI_RS05895	COG1372	Participates in initiation and elongation during chromosome replication
SYNGTI_RS05910	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SYNGTI_RS05910	COG0646	methionine synthase
SYNGTI_RS05920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYNGTI_RS05945	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_RS05955	COG2197	response regulator
SYNGTI_RS05960	COG2203	Gaf domain
SYNGTI_RS05960	COG4251	negative regulation of phosphorylation
SYNGTI_RS05960	COG5001	Diguanylate cyclase
SYNGTI_RS05960	COG3706	GGDEF domain
SYNGTI_RS05970	COG0616	signal peptide processing
SYNGTI_RS05980	COG0596	Alpha beta hydrolase
SYNGTI_RS05985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SYNGTI_RS05995	COG0747	negative chemotaxis
SYNGTI_RS06005	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYNGTI_RS06045	COG4968	Prepilin-type N-terminal cleavage methylation domain
SYNGTI_RS06050	COG4968	Prepilin-type N-terminal cleavage methylation domain
SYNGTI_RS06075	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_RS06080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNGTI_RS06085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SYNGTI_RS06095	COG2199	diguanylate cyclase activity
SYNGTI_RS06100	COG0750	zinc metalloprotease
SYNGTI_RS06105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SYNGTI_RS06120	COG0590	tRNA wobble adenosine to inosine editing
SYNGTI_RS06130	COG0415	Belongs to the DNA photolyase family
SYNGTI_RS06140	COG3409	Peptidoglycan-binding domain 1 protein
SYNGTI_RS06140	COG3429	Glucose-6-phosphate dehydrogenase subunit
SYNGTI_RS06150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYNGTI_RS06155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SYNGTI_RS06170	COG1122	ATPase activity
SYNGTI_RS06175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYNGTI_RS06185	COG0678	peroxiredoxin activity
SYNGTI_RS06225	COG1252	NADH dehydrogenase
SYNGTI_RS06235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SYNGTI_RS06260	COG0415	Belongs to the DNA photolyase family
SYNGTI_RS06275	COG1595	DNA-templated transcription, initiation
SYNGTI_RS06320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SYNGTI_RS06330	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SYNGTI_RS06335	COG3339	Conserved Protein
SYNGTI_RS06345	COG0312	modulator of DNA gyrase
SYNGTI_RS06350	COG0482	sulfurtransferase activity
SYNGTI_RS06365	COG0488	(ABC) transporter
SYNGTI_RS06370	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SYNGTI_RS06380	COG0284	orotidine-5'-phosphate decarboxylase activity
SYNGTI_RS06430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SYNGTI_RS06440	COG0697	spore germination
SYNGTI_RS06475	COG0583	DNA-binding transcription factor activity
SYNGTI_RS06495	COG2814	Major facilitator Superfamily
SYNGTI_RS06500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYNGTI_RS06505	COG0573	inorganic phosphate transmembrane transporter activity
SYNGTI_RS06510	COG0581	inorganic phosphate transmembrane transporter activity
SYNGTI_RS06515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYNGTI_RS06520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNGTI_RS06525	COG2154	pterin-4-alpha-carbinolamine dehydratase
SYNGTI_RS06550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SYNGTI_RS06550	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYNGTI_RS06555	COG1562	ergosterol biosynthetic process
SYNGTI_RS06560	COG3788	relative of glutathione S-transferase, MAPEG superfamily
SYNGTI_RS06565	COG0831	urea catabolic process
SYNGTI_RS06575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SYNGTI_RS06595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SYNGTI_RS06600	COG0730	response to heat
SYNGTI_RS06610	COG2188	Transcriptional regulator
SYNGTI_RS06625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYNGTI_RS06630	COG0640	Transcriptional regulator
SYNGTI_RS06635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SYNGTI_RS06640	COG1754	DNA topoisomerase type I activity
SYNGTI_RS06640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SYNGTI_RS06675	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SYNGTI_RS06705	COG2264	protein methyltransferase activity
SYNGTI_RS06710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SYNGTI_RS06725	COG0386	Belongs to the glutathione peroxidase family
SYNGTI_RS06730	COG0183	Belongs to the thiolase family
SYNGTI_RS06735	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_RS06745	COG3850	Histidine kinase
SYNGTI_RS06745	COG2205	protein histidine kinase activity
SYNGTI_RS06745	COG4999	Histidine kinase
SYNGTI_RS06745	COG3437	response regulator, receiver
SYNGTI_RS06765	COG4242	Belongs to the peptidase S51 family
SYNGTI_RS06770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYNGTI_RS06770	COG0189	ligase activity
SYNGTI_RS06800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNGTI_RS06805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYNGTI_RS06815	COG0285	dihydrofolate synthase activity
SYNGTI_RS06835	COG4636	protein conserved in cyanobacteria
SYNGTI_RS06850	COG1606	tRNA processing
SYNGTI_RS06860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYNGTI_RS06870	COG2045	Belongs to the ComB family
SYNGTI_RS06875	COG0778	Nitroreductase
SYNGTI_RS06880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYNGTI_RS06890	COG0516	GMP reductase activity
SYNGTI_RS06895	COG0395	ABC-type sugar transport system, permease component
SYNGTI_RS06900	COG3268	Saccharopine dehydrogenase
SYNGTI_RS06915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYNGTI_RS06920	COG1121	(ABC) transporter
SYNGTI_RS06925	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYNGTI_RS06935	COG4251	negative regulation of phosphorylation
SYNGTI_RS06940	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SYNGTI_RS06950	COG0583	DNA-binding transcription factor activity
SYNGTI_RS06955	COG0025	NhaP-type Na H and K H
SYNGTI_RS06960	COG2197	response regulator
SYNGTI_RS06965	COG5002	protein histidine kinase activity
SYNGTI_RS06970	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SYNGTI_RS06975	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SYNGTI_RS06985	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SYNGTI_RS06990	COG2205	protein histidine kinase activity
SYNGTI_RS07000	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYNGTI_RS07020	COG2385	sporulation resulting in formation of a cellular spore
SYNGTI_RS07025	COG0649	NAD binding
SYNGTI_RS07040	COG0429	hydrolase of the alpha beta-hydrolase fold
SYNGTI_RS07050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SYNGTI_RS07055	COG3536	Protein conserved in bacteria
SYNGTI_RS07060	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SYNGTI_RS07065	COG0716	FMN binding
SYNGTI_RS07075	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SYNGTI_RS07080	COG0012	GTP binding
SYNGTI_RS07085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNGTI_RS07140	COG3842	ATPase activity
SYNGTI_RS07150	COG1840	ABC-type Fe3 transport system, periplasmic component
SYNGTI_RS07155	COG0222	ribosome binding
SYNGTI_RS07165	COG2066	Belongs to the glutaminase family
SYNGTI_RS07185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SYNGTI_RS07200	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SYNGTI_RS07205	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SYNGTI_RS07210	COG1333	cytochrome c biogenesis protein
SYNGTI_RS07220	COG1657	PFAM Prenyltransferase squalene oxidase
SYNGTI_RS07270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYNGTI_RS07280	COG1494	fructose-1,6-bisphosphatase
SYNGTI_RS07290	COG2346	COG2346, Truncated hemoglobins
SYNGTI_RS07295	COG2205	protein histidine kinase activity
SYNGTI_RS07295	COG4999	Histidine kinase
SYNGTI_RS07295	COG3437	response regulator, receiver
SYNGTI_RS07295	COG3850	Histidine kinase
SYNGTI_RS07305	COG3437	response regulator, receiver
SYNGTI_RS07310	COG1917	Cupin 2, conserved barrel domain protein
SYNGTI_RS07315	COG0552	protein localization to endoplasmic reticulum
SYNGTI_RS07325	COG0784	Response regulator, receiver
SYNGTI_RS07325	COG5002	protein histidine kinase activity
SYNGTI_RS07325	COG2205	protein histidine kinase activity
SYNGTI_RS07330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SYNGTI_RS07340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SYNGTI_RS07360	COG0667	Aldo Keto reductase
SYNGTI_RS07365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNGTI_RS07375	COG0442	prolyl-tRNA aminoacylation
SYNGTI_RS07385	COG4372	Transposase
SYNGTI_RS07390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNGTI_RS07415	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_RS07420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SYNGTI_RS07425	COG0416	fatty acid biosynthetic process
SYNGTI_RS07430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYNGTI_RS07445	COG0347	Belongs to the P(II) protein family
SYNGTI_RS07450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYNGTI_RS07480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SYNGTI_RS07485	COG0473	3-isopropylmalate dehydrogenase activity
SYNGTI_RS07495	COG1575	Belongs to the MenA family. Type 1 subfamily
SYNGTI_RS07505	COG0656	L-ascorbic acid biosynthetic process
SYNGTI_RS07510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SYNGTI_RS07535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SYNGTI_RS07550	COG2161	toxin-antitoxin pair type II binding
SYNGTI_RS07555	COG4115	mRNA cleavage
SYNGTI_RS07570	COG3385	transposase activity
SYNGTI_RS07585	COG3385	transposase activity
SYNGTI_RS07595	COG0517	IMP dehydrogenase activity
SYNGTI_RS07595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SYNGTI_RS07610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYNGTI_RS07620	COG1215	transferase activity, transferring glycosyl groups
SYNGTI_RS07645	COG1216	Glycosyl transferase, family 2
SYNGTI_RS07650	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SYNGTI_RS07665	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_RS07695	COG0463	Glycosyl transferase, family 2
SYNGTI_RS07700	COG0113	porphobilinogen synthase activity
SYNGTI_RS07710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SYNGTI_RS07715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SYNGTI_RS07745	COG0312	modulator of DNA gyrase
SYNGTI_RS07750	COG2890	protein-(glutamine-N5) methyltransferase activity
SYNGTI_RS07755	COG2205	protein histidine kinase activity
SYNGTI_RS07770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYNGTI_RS07775	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SYNGTI_RS07800	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_RS07810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYNGTI_RS07810	COG2205	protein histidine kinase activity
SYNGTI_RS07815	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SYNGTI_RS07820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SYNGTI_RS07825	COG0612	Peptidase, M16
SYNGTI_RS07830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYNGTI_RS07835	COG3259	Nickel-dependent hydrogenase
SYNGTI_RS07850	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
SYNGTI_RS07855	COG1034	ATP synthesis coupled electron transport
SYNGTI_RS07890	COG0702	epimerase
SYNGTI_RS07925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SYNGTI_RS07930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SYNGTI_RS07945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SYNGTI_RS07955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYNGTI_RS07960	COG0673	inositol 2-dehydrogenase activity
SYNGTI_RS07975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SYNGTI_RS07980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SYNGTI_RS08015	COG0095	Lipoate-protein ligase
SYNGTI_RS08035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SYNGTI_RS08045	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SYNGTI_RS08060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SYNGTI_RS08065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SYNGTI_RS08070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYNGTI_RS08075	COG0457	Tetratricopeptide repeat
SYNGTI_RS08080	COG1160	GTP binding
SYNGTI_RS08100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SYNGTI_RS08115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SYNGTI_RS08120	COG0052	Belongs to the universal ribosomal protein uS2 family
SYNGTI_RS08130	COG0387	Pfam Sodium calcium exchanger
SYNGTI_RS08135	COG0717	Belongs to the dCTP deaminase family
SYNGTI_RS08170	COG3385	transposase activity
SYNGTI_RS08175	COG1253	flavin adenine dinucleotide binding
SYNGTI_RS08185	COG3046	protein related to deoxyribodipyrimidine photolyase
SYNGTI_RS08190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SYNGTI_RS08190	COG0617	tRNA 3'-terminal CCA addition
SYNGTI_RS08190	COG0517	IMP dehydrogenase activity
SYNGTI_RS08200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYNGTI_RS08220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SYNGTI_RS08220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SYNGTI_RS08225	COG0288	reversible hydration of carbon dioxide
SYNGTI_RS08230	COG1045	serine acetyltransferase
SYNGTI_RS08240	COG0166	Belongs to the GPI family
SYNGTI_RS08245	COG3239	Fatty acid desaturase
SYNGTI_RS08250	COG1672	PFAM Archaeal ATPase
SYNGTI_RS08255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SYNGTI_RS08260	COG2010	Cytochrome c
SYNGTI_RS08265	COG0359	binds to the 23S rRNA
SYNGTI_RS08275	COG1032	radical SAM domain protein
SYNGTI_RS08305	COG0298	carbon dioxide binding
SYNGTI_RS08310	COG0109	protoheme IX farnesyltransferase activity
SYNGTI_RS08315	COG1612	heme a metabolic process
SYNGTI_RS08335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SYNGTI_RS08340	COG1716	ATPase activity
SYNGTI_RS08340	COG5001	Diguanylate cyclase
SYNGTI_RS08345	COG3631	Ketosteroid isomerase-related protein
SYNGTI_RS08355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYNGTI_RS08355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYNGTI_RS08365	COG0107	imidazoleglycerol-phosphate synthase activity
SYNGTI_RS08390	COG2205	protein histidine kinase activity
SYNGTI_RS08390	COG2202	Pas domain
SYNGTI_RS08410	COG2205	protein histidine kinase activity
SYNGTI_RS08410	COG3437	response regulator, receiver
SYNGTI_RS08410	COG3850	Histidine kinase
SYNGTI_RS08410	COG4999	Histidine kinase
SYNGTI_RS08420	COG4956	integral membrane protein (PIN domain superfamily)
SYNGTI_RS08435	COG1160	GTP binding
SYNGTI_RS08445	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SYNGTI_RS08460	COG0432	Pfam Uncharacterised protein family UPF0047
SYNGTI_RS08465	COG2197	response regulator
SYNGTI_RS08470	COG3842	ATPase activity
SYNGTI_RS08480	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SYNGTI_RS08485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYNGTI_RS08495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYNGTI_RS08500	COG5398	heme oxygenase
SYNGTI_RS08505	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYNGTI_RS08515	COG1316	TRANSCRIPTIONal
SYNGTI_RS08530	COG2770	Histidine kinase
SYNGTI_RS08530	COG2208	phosphoserine phosphatase activity
SYNGTI_RS08535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SYNGTI_RS08545	COG0539	negative regulation of cytoplasmic translation
SYNGTI_RS08550	COG0358	DNA primase activity
SYNGTI_RS08560	COG0009	L-threonylcarbamoyladenylate synthase
SYNGTI_RS08580	COG0589	response to stress
SYNGTI_RS08605	COG2082	Precorrin-8x methylmutase
SYNGTI_RS08615	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SYNGTI_RS08620	COG0594	ribonuclease P activity
SYNGTI_RS08630	COG0706	membrane insertase activity
SYNGTI_RS08640	COG0484	heat shock protein binding
SYNGTI_RS08645	COG0483	inositol monophosphate 1-phosphatase activity
SYNGTI_RS08650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYNGTI_RS08660	COG0791	NLP P60 protein
SYNGTI_RS08675	COG0540	Belongs to the ATCase OTCase family
SYNGTI_RS08690	COG1215	transferase activity, transferring glycosyl groups
SYNGTI_RS08700	COG0300	oxidoreductase activity
SYNGTI_RS08700	COG3000	fatty acid hydroxylase
SYNGTI_RS08705	COG2211	Major facilitator Superfamily
SYNGTI_RS08725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNGTI_RS08740	COG0723	plastoquinol--plastocyanin reductase activity
SYNGTI_RS08745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYNGTI_RS08750	COG2274	protein secretion by the type I secretion system
SYNGTI_RS08760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYNGTI_RS08765	COG2192	nodulation
SYNGTI_RS08775	COG0772	Belongs to the SEDS family
SYNGTI_RS08780	COG0405	Gamma-glutamyltransferase
SYNGTI_RS08795	COG3659	wide pore channel activity
SYNGTI_RS08835	COG0037	tRNA processing
SYNGTI_RS08840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SYNGTI_RS08845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_RS08850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_RS08855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_RS08895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNGTI_RS08905	COG0628	permease
SYNGTI_RS08920	COG0066	3-isopropylmalate dehydratase activity
SYNGTI_RS08925	COG0504	CTP synthase activity
SYNGTI_RS08940	COG2204	response regulator
SYNGTI_RS08950	COG0259	pyridoxamine-phosphate oxidase activity
SYNGTI_RS08970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SYNGTI_RS08985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYNGTI_RS08990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SYNGTI_RS08995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SYNGTI_RS08995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SYNGTI_RS09000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SYNGTI_RS09010	COG1619	proteins homologs of microcin C7 resistance protein MccF
SYNGTI_RS09015	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_RS09030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SYNGTI_RS09040	COG0051	transcription antitermination factor activity, RNA binding
SYNGTI_RS09045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SYNGTI_RS09050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYNGTI_RS09055	COG0049	tRNA binding
SYNGTI_RS09060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SYNGTI_RS09070	COG0151	Belongs to the GarS family
SYNGTI_RS09080	COG0698	ribose 5-phosphate isomerase
SYNGTI_RS09115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SYNGTI_RS09120	COG2046	Belongs to the sulfate adenylyltransferase family
SYNGTI_RS09125	COG0297	glycogen (starch) synthase activity
SYNGTI_RS09140	COG0644	oxidoreductase
SYNGTI_RS09145	COG0371	Dehydrogenase
SYNGTI_RS09160	COG2119	membrane
SYNGTI_RS09165	COG0386	Belongs to the glutathione peroxidase family
SYNGTI_RS09180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SYNGTI_RS09200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SYNGTI_RS09205	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SYNGTI_RS09215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SYNGTI_RS09220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNGTI_RS09230	COG0375	protein maturation
SYNGTI_RS09245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SYNGTI_RS09250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SYNGTI_RS09255	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SYNGTI_RS09260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYNGTI_RS09265	COG1134	teichoic acid transport
SYNGTI_RS09290	COG1012	belongs to the aldehyde dehydrogenase family
SYNGTI_RS09300	COG3385	transposase activity
SYNGTI_RS09335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYNGTI_RS09345	COG1304	FMN binding
SYNGTI_RS09350	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS09360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SYNGTI_RS09370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNGTI_RS09370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SYNGTI_RS09375	COG3706	GGDEF domain
SYNGTI_RS09375	COG2203	Gaf domain
SYNGTI_RS09375	COG5001	Diguanylate cyclase
SYNGTI_RS09375	COG4251	negative regulation of phosphorylation
SYNGTI_RS09380	COG0784	Response regulator, receiver
SYNGTI_RS09390	COG0072	phenylalanine-tRNA ligase activity
SYNGTI_RS09390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNGTI_RS09395	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_RS09395	COG0515	serine threonine protein kinase
SYNGTI_RS09400	COG2197	response regulator
SYNGTI_RS09405	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SYNGTI_RS09420	COG0157	Belongs to the NadC ModD family
SYNGTI_RS09435	COG2082	Precorrin-8x methylmutase
SYNGTI_RS09440	COG0612	Peptidase, M16
SYNGTI_RS09445	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYNGTI_RS09455	COG0656	L-ascorbic acid biosynthetic process
SYNGTI_RS09460	COG3588	fructose-bisphosphate aldolase
SYNGTI_RS09470	COG0798	PFAM Bile acid sodium symporter
SYNGTI_RS09475	COG0431	NADPH-dependent FMN reductase
SYNGTI_RS09480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYNGTI_RS09500	COG0488	(ABC) transporter
SYNGTI_RS09510	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SYNGTI_RS09530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SYNGTI_RS09535	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SYNGTI_RS09540	COG0561	phosphatase activity
SYNGTI_RS09545	COG1366	Belongs to the anti-sigma-factor antagonist family
SYNGTI_RS09550	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SYNGTI_RS09555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNGTI_RS09565	COG0215	cysteine-tRNA ligase activity
SYNGTI_RS09570	COG0424	maF-like protein
SYNGTI_RS09585	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SYNGTI_RS09590	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYNGTI_RS09595	COG0463	Glycosyl transferase, family 2
SYNGTI_RS09600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SYNGTI_RS09615	COG1472	Belongs to the glycosyl hydrolase 3 family
SYNGTI_RS09620	COG2816	NAD+ diphosphatase activity
SYNGTI_RS09625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SYNGTI_RS09630	COG1280	lysine exporter protein (LysE YggA)
SYNGTI_RS09645	COG0564	pseudouridine synthase activity
SYNGTI_RS09655	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_RS09695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SYNGTI_RS09710	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_RS09720	COG0500	methyltransferase
SYNGTI_RS09725	COG0542	response to heat
SYNGTI_RS09735	COG0572	uridine kinase
SYNGTI_RS09740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SYNGTI_RS09745	COG0561	phosphatase activity
SYNGTI_RS09760	COG0571	ribonuclease III activity
SYNGTI_RS09765	COG0390	transport system, permease component
SYNGTI_RS09770	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SYNGTI_RS09775	COG2161	toxin-antitoxin pair type II binding
SYNGTI_RS09790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SYNGTI_RS09795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNGTI_RS09795	COG0426	domain, Protein
SYNGTI_RS09800	COG0497	DNA recombination
SYNGTI_RS09810	COG3751	2OG-Fe(II) oxygenase superfamily
SYNGTI_RS09840	COG2161	toxin-antitoxin pair type II binding
SYNGTI_RS09865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SYNGTI_RS09870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNGTI_RS09885	COG1446	asparaginase
SYNGTI_RS09890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SYNGTI_RS09900	COG0832	Belongs to the urease beta subunit family
SYNGTI_RS09910	COG2226	methyltransferase
SYNGTI_RS09925	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SYNGTI_RS09935	COG0025	NhaP-type Na H and K H
SYNGTI_RS09945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYNGTI_RS09955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SYNGTI_RS09995	COG3239	Fatty acid desaturase
SYNGTI_RS10005	COG1950	PFAM Membrane protein of
SYNGTI_RS10020	COG1253	flavin adenine dinucleotide binding
SYNGTI_RS10025	COG0228	four-way junction DNA binding
SYNGTI_RS10045	COG2010	Cytochrome c
SYNGTI_RS10060	COG0802	atpase or kinase
SYNGTI_RS10065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYNGTI_RS10065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYNGTI_RS10090	COG0126	phosphoglycerate kinase activity
SYNGTI_RS10095	COG0583	DNA-binding transcription factor activity
SYNGTI_RS10100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SYNGTI_RS10135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYNGTI_RS10150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SYNGTI_RS10155	COG0347	Belongs to the P(II) protein family
SYNGTI_RS10170	COG0135	phosphoribosylanthranilate isomerase activity
SYNGTI_RS10175	COG0697	spore germination
SYNGTI_RS10190	COG0418	dihydroorotase activity
SYNGTI_RS10195	COG2226	methyltransferase
SYNGTI_RS10210	COG2319	Wd-40 repeat
SYNGTI_RS10210	COG1672	PFAM Archaeal ATPase
SYNGTI_RS10255	COG2815	serine threonine protein kinase
SYNGTI_RS10255	COG0515	serine threonine protein kinase
SYNGTI_RS10280	COG0233	cytoplasmic translational termination
SYNGTI_RS10285	COG0528	UMP kinase activity
SYNGTI_RS10290	COG1598	PFAM Uncharacterised protein family UPF0150
SYNGTI_RS10300	COG0542	response to heat
SYNGTI_RS10325	COG1459	type II secretion system
SYNGTI_RS10330	COG0740	serine-type endopeptidase activity
SYNGTI_RS10335	COG0740	serine-type endopeptidase activity
SYNGTI_RS10340	COG0006	proline dipeptidase activity
SYNGTI_RS10345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SYNGTI_RS10365	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SYNGTI_RS10375	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SYNGTI_RS10380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SYNGTI_RS10415	COG2165	general secretion pathway protein
SYNGTI_RS10420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SYNGTI_RS10460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SYNGTI_RS10480	COG0105	UTP biosynthetic process
SYNGTI_RS10510	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYNGTI_RS10515	COG2937	Belongs to the GPAT DAPAT family
SYNGTI_RS10525	COG0501	Belongs to the peptidase M48B family
SYNGTI_RS10545	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SYNGTI_RS10555	COG0463	Glycosyl transferase, family 2
SYNGTI_RS10565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SYNGTI_RS10580	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYNGTI_RS10590	COG2217	Heavy metal translocating P-type atpase
SYNGTI_RS10600	COG0217	transcriptional regulatory protein
SYNGTI_RS10605	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SYNGTI_RS10610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SYNGTI_RS10615	COG0739	heme binding
SYNGTI_RS10620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SYNGTI_RS10625	COG0321	lipoyl(octanoyl) transferase activity
SYNGTI_RS10640	COG0297	glycogen (starch) synthase activity
SYNGTI_RS10655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNGTI_RS10660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SYNGTI_RS10665	COG0784	Response regulator, receiver
SYNGTI_RS10665	COG0643	Histidine kinase
SYNGTI_RS10665	COG0784	Response regulator, receiver
SYNGTI_RS10665	COG0643	Histidine kinase
SYNGTI_RS10665	COG2198	Histidine kinase
SYNGTI_RS10665	COG2198	Histidine kinase
SYNGTI_RS10685	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_RS10700	COG1178	ABC-type Fe3 transport system permease component
SYNGTI_RS10705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYNGTI_RS10730	COG2197	response regulator
SYNGTI_RS10735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_RS10740	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_RS10765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNGTI_RS10765	COG0237	dephospho-CoA kinase activity
SYNGTI_RS10805	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNGTI_RS10815	COG0517	IMP dehydrogenase activity
SYNGTI_RS10815	COG0516	GMP reductase activity
SYNGTI_RS10825	COG1937	Protein conserved in bacteria
SYNGTI_RS10840	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SYNGTI_RS10860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYNGTI_RS10865	COG0443	Heat shock 70 kDa protein
SYNGTI_RS10885	COG1587	Uroporphyrinogen-III synthase
SYNGTI_RS10890	COG2319	Wd-40 repeat
SYNGTI_RS10910	COG3385	transposase activity
SYNGTI_RS10920	COG1381	Involved in DNA repair and RecF pathway recombination
SYNGTI_RS10935	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SYNGTI_RS10955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SYNGTI_RS10960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SYNGTI_RS10965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYNGTI_RS10970	COG5001	Diguanylate cyclase
SYNGTI_RS10980	COG1187	pseudouridine synthase activity
SYNGTI_RS10985	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SYNGTI_RS11015	COG1012	belongs to the aldehyde dehydrogenase family
SYNGTI_RS11020	COG5002	protein histidine kinase activity
SYNGTI_RS11025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SYNGTI_RS11030	COG2308	Evidence 4 Homologs of previously reported genes of
SYNGTI_RS11060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SYNGTI_RS11070	COG0346	lactoylglutathione lyase activity
SYNGTI_RS11080	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_RS11085	COG0742	ribosomal rna small subunit methyltransferase
SYNGTI_RS11090	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_RS11095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SYNGTI_RS11115	COG1104	cysteine desulfurase activity
SYNGTI_RS11120	COG1040	competence protein
SYNGTI_RS11125	COG1376	ErfK ybiS ycfS ynhG family protein
SYNGTI_RS11140	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYNGTI_RS11150	COG3659	wide pore channel activity
SYNGTI_RS11155	COG0477	Major facilitator Superfamily
SYNGTI_RS11160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYNGTI_RS11165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYNGTI_RS11170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYNGTI_RS11175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SYNGTI_RS11180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SYNGTI_RS11185	COG2003	Belongs to the UPF0758 family
SYNGTI_RS11190	COG1054	Belongs to the UPF0176 family
SYNGTI_RS11200	COG0411	ABC transporter
SYNGTI_RS11220	COG1131	(ABC) transporter
SYNGTI_RS11230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYNGTI_RS11240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYNGTI_RS11250	COG0450	alkyl hydroperoxide reductase
SYNGTI_RS11255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SYNGTI_RS11265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SYNGTI_RS11275	COG1231	oxidoreductase activity
SYNGTI_RS11280	COG2205	protein histidine kinase activity
SYNGTI_RS11290	COG0149	triose-phosphate isomerase activity
SYNGTI_RS11295	COG0628	permease
SYNGTI_RS11310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SYNGTI_RS11315	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SYNGTI_RS11330	COG0571	ribonuclease III activity
SYNGTI_RS11335	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SYNGTI_RS11360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SYNGTI_RS11380	COG3385	transposase activity
SYNGTI_RS11400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYNGTI_RS11405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SYNGTI_RS11430	COG1748	Saccharopine dehydrogenase
SYNGTI_RS11440	COG0601	transmembrane transport
SYNGTI_RS11445	COG0124	histidyl-tRNA synthetase
SYNGTI_RS11490	COG0542	response to heat
SYNGTI_RS11495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SYNGTI_RS11500	COG0191	fructose-bisphosphate aldolase activity
SYNGTI_RS11505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SYNGTI_RS11525	COG0793	Belongs to the peptidase S41A family
SYNGTI_RS11530	COG1850	ribulose-bisphosphate carboxylase activity
SYNGTI_RS11540	COG4451	ribulose bisphosphate carboxylase, small
SYNGTI_RS11550	COG1285	pathogenesis
SYNGTI_RS11560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYNGTI_RS11565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYNGTI_RS11575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYNGTI_RS11580	COG0114	fumarate hydratase activity
SYNGTI_RS11610	COG0436	Aminotransferase
SYNGTI_RS11615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNGTI_RS11620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SYNGTI_RS11625	COG0616	signal peptide processing
SYNGTI_RS11630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYNGTI_RS11640	COG0519	Catalyzes the synthesis of GMP from XMP
SYNGTI_RS11640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SYNGTI_RS11650	COG1968	undecaprenyl-diphosphatase activity
SYNGTI_RS11670	COG5322	oxidoreductase activity
SYNGTI_RS11675	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYNGTI_RS11685	COG0751	glycine-tRNA ligase activity
SYNGTI_RS11700	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SYNGTI_RS11705	COG5002	protein histidine kinase activity
SYNGTI_RS11710	COG0445	tRNA wobble uridine modification
SYNGTI_RS11730	COG3794	PFAM blue (type 1) copper domain protein
SYNGTI_RS11745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNGTI_RS11750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYNGTI_RS11755	COG0805	protein transport
SYNGTI_RS11760	COG2084	Dehydrogenase
SYNGTI_RS11775	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SYNGTI_RS11785	COG0586	Pfam SNARE associated Golgi protein
SYNGTI_RS11790	COG3118	belongs to the thioredoxin family
SYNGTI_RS11795	COG3751	2OG-Fe(II) oxygenase superfamily
SYNGTI_RS11800	COG0459	protein refolding
SYNGTI_RS11805	COG1131	(ABC) transporter
SYNGTI_RS11830	COG4399	Belongs to the UPF0754 family
SYNGTI_RS11835	COG0824	Thioesterase
SYNGTI_RS11840	COG4948	Mandelate Racemase Muconate Lactonizing
SYNGTI_RS11845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNGTI_RS11850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SYNGTI_RS11855	COG0511	ligase activity, forming carbon-carbon bonds
SYNGTI_RS11860	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNGTI_RS11885	COG0277	FAD linked oxidase domain protein
SYNGTI_RS11905	COG0436	Aminotransferase
SYNGTI_RS11910	COG0372	Belongs to the citrate synthase family
SYNGTI_RS11915	COG2062	phosphohistidine phosphatase, SixA
SYNGTI_RS11920	COG0596	Alpha beta hydrolase
SYNGTI_RS11935	COG1234	tRNA 3'-trailer cleavage
SYNGTI_RS11950	COG0788	formyltetrahydrofolate deformylase activity
SYNGTI_RS11970	COG0625	glutathione transferase activity
SYNGTI_RS11980	COG0440	acetolactate synthase activity
SYNGTI_RS11990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SYNGTI_RS11995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SYNGTI_RS12005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYNGTI_RS12010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYNGTI_RS12020	COG0628	permease
SYNGTI_RS12055	COG0628	permease
SYNGTI_RS12060	COG0443	Heat shock 70 kDa protein
SYNGTI_RS12065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SYNGTI_RS12070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYNGTI_RS12075	COG0116	Belongs to the methyltransferase superfamily
SYNGTI_RS12085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYNGTI_RS12085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYNGTI_RS12090	COG0612	Peptidase, M16
SYNGTI_RS12095	COG0489	protein tyrosine kinase activity
SYNGTI_RS12100	COG0439	Biotin carboxylase
SYNGTI_RS12105	COG3224	Antibiotic biosynthesis monooxygenase
SYNGTI_RS12110	COG0590	tRNA wobble adenosine to inosine editing
SYNGTI_RS12115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SYNGTI_RS12130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SYNGTI_RS12145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYNGTI_RS12150	COG4251	negative regulation of phosphorylation
SYNGTI_RS12155	COG0784	Response regulator, receiver
SYNGTI_RS12160	COG0556	nucleotide-excision repair
SYNGTI_RS12185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNGTI_RS12190	COG2890	protein-(glutamine-N5) methyltransferase activity
SYNGTI_RS12195	COG0525	valine-tRNA ligase activity
SYNGTI_RS12200	COG5002	protein histidine kinase activity
SYNGTI_RS12210	COG0728	peptidoglycan biosynthetic process
SYNGTI_RS12225	COG0318	PFAM AMP-dependent synthetase and ligase
SYNGTI_RS12240	COG0460	homoserine dehydrogenase
SYNGTI_RS12245	COG2091	lysine biosynthetic process via aminoadipic acid
SYNGTI_RS12255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SYNGTI_RS12275	COG0475	glutathione-regulated potassium exporter activity
SYNGTI_RS12290	COG4232	protein-disulfide reductase activity
SYNGTI_RS12300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYNGTI_RS12305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYNGTI_RS12310	COG0581	inorganic phosphate transmembrane transporter activity
SYNGTI_RS12325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYNGTI_RS12340	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SYNGTI_RS12345	COG1842	Phage shock protein A
SYNGTI_RS12360	COG0653	protein targeting
SYNGTI_RS12365	COG2119	membrane
SYNGTI_RS12375	COG2255	four-way junction helicase activity
SYNGTI_RS12380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNGTI_RS12380	COG2022	thiamine diphosphate biosynthetic process
SYNGTI_RS12390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYNGTI_RS12400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SYNGTI_RS12415	COG0752	glycyl-tRNA synthetase alpha subunit
SYNGTI_RS12420	COG0668	transmembrane transport
SYNGTI_RS12425	COG5002	protein histidine kinase activity
SYNGTI_RS12440	COG2211	Major facilitator Superfamily
SYNGTI_RS12455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYNGTI_RS12460	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SYNGTI_RS12490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNGTI_RS12500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SYNGTI_RS12510	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS12515	COG0406	alpha-ribazole phosphatase activity
SYNGTI_RS12525	COG0589	response to stress
SYNGTI_RS12525	COG0475	glutathione-regulated potassium exporter activity
SYNGTI_RS12540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYNGTI_RS12550	COG1122	ATPase activity
SYNGTI_RS12560	COG0310	cobalt ion transport
SYNGTI_RS12585	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_RS12590	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYNGTI_RS12605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYNGTI_RS12610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SYNGTI_RS12620	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SYNGTI_RS12630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYNGTI_RS12645	COG1598	PFAM Uncharacterised protein family UPF0150
SYNGTI_RS12655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYNGTI_RS12665	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SYNGTI_RS12670	COG0302	gtp cyclohydrolase
SYNGTI_RS12675	COG1058	Belongs to the CinA family
SYNGTI_RS12675	COG1546	Belongs to the CinA family
SYNGTI_RS12680	COG0792	nuclease activity
SYNGTI_RS12690	COG2247	cell wall binding repeat
SYNGTI_RS12690	COG2385	sporulation resulting in formation of a cellular spore
SYNGTI_RS12695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SYNGTI_RS12705	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SYNGTI_RS12730	COG0121	glutamine amidotransferase
SYNGTI_RS12735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNGTI_RS12740	COG2048	Heterodisulfide reductase, subunit B
SYNGTI_RS12745	COG0762	integral membrane protein
SYNGTI_RS12755	COG4178	(ABC) transporter
SYNGTI_RS12780	COG0824	Thioesterase
SYNGTI_RS12785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYNGTI_RS12810	COG2205	protein histidine kinase activity
SYNGTI_RS12810	COG2202	Pas domain
SYNGTI_RS12825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SYNGTI_RS12830	COG0646	methionine synthase
SYNGTI_RS12830	COG1410	methionine synthase
SYNGTI_RS12865	COG0646	methionine synthase
SYNGTI_RS12865	COG1410	methionine synthase
SYNGTI_RS12880	COG1309	transcriptional regulator
SYNGTI_RS12885	COG0534	Mate efflux family protein
SYNGTI_RS12900	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SYNGTI_RS12905	COG0303	'Molybdopterin
SYNGTI_RS12910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYNGTI_RS12915	COG0746	molybdenum cofactor guanylyltransferase activity
SYNGTI_RS12915	COG0315	cyclic pyranopterin monophosphate synthase activity
SYNGTI_RS12925	COG0314	molybdopterin synthase activity
SYNGTI_RS12935	COG0606	chelatase, subunit chli
SYNGTI_RS12940	COG1032	radical SAM domain protein
SYNGTI_RS12980	COG0156	8-amino-7-oxononanoate synthase activity
SYNGTI_RS12985	COG0024	Methionine aminopeptidase
SYNGTI_RS12995	COG0494	nUDIX hydrolase
SYNGTI_RS13000	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SYNGTI_RS13005	COG0039	L-malate dehydrogenase activity
SYNGTI_RS13020	COG0193	aminoacyl-tRNA hydrolase activity
SYNGTI_RS13050	COG0024	Methionine aminopeptidase
SYNGTI_RS13055	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SYNGTI_RS13070	COG4243	Vitamin k epoxide reductase
SYNGTI_RS13075	COG0426	domain, Protein
SYNGTI_RS13075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNGTI_RS13080	COG0613	PHP domain protein
SYNGTI_RS13085	COG2251	uridine kinase activity
SYNGTI_RS13090	COG3063	Type IV pilus biogenesis stability protein PilW
SYNGTI_RS13095	COG0023	Translation Initiation Factor
SYNGTI_RS13135	COG2954	triphosphatase activity
SYNGTI_RS13145	COG2124	cytochrome p450
SYNGTI_RS13155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYNGTI_RS13170	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SYNGTI_RS13195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNGTI_RS13205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SYNGTI_RS13210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SYNGTI_RS13215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SYNGTI_RS13220	COG5001	Diguanylate cyclase
SYNGTI_RS13220	COG2203	Gaf domain
SYNGTI_RS13220	COG3706	GGDEF domain
SYNGTI_RS13220	COG4251	negative regulation of phosphorylation
SYNGTI_RS13225	COG0659	secondary active sulfate transmembrane transporter activity
SYNGTI_RS13230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SYNGTI_RS13245	COG0305	Participates in initiation and elongation during chromosome replication
SYNGTI_RS13245	COG1372	Participates in initiation and elongation during chromosome replication
SYNGTI_RS13250	COG0714	Associated with various cellular activities
SYNGTI_RS13265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYNGTI_RS13270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SYNGTI_RS13275	COG2226	methyltransferase
SYNGTI_RS13280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNGTI_RS13285	COG0154	amidase activity
SYNGTI_RS13300	COG2203	Gaf domain
SYNGTI_RS13300	COG4251	negative regulation of phosphorylation
SYNGTI_RS13300	COG5001	Diguanylate cyclase
SYNGTI_RS13300	COG3706	GGDEF domain
SYNGTI_RS13305	COG0617	tRNA 3'-terminal CCA addition
SYNGTI_RS13315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYNGTI_RS13330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SYNGTI_RS13340	COG1959	2 iron, 2 sulfur cluster binding
SYNGTI_RS13345	COG3706	GGDEF domain
SYNGTI_RS13345	COG5001	Diguanylate cyclase
SYNGTI_RS13345	COG2203	Gaf domain
SYNGTI_RS13345	COG4251	negative regulation of phosphorylation
SYNGTI_RS13350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SYNGTI_RS13360	COG0357	Ribosomal RNA small subunit methyltransferase G
SYNGTI_RS13375	COG0719	Fe-S assembly protein
SYNGTI_RS13380	COG0396	ATPase activity
SYNGTI_RS13385	COG0719	Fe-S assembly protein
SYNGTI_RS13390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYNGTI_RS13395	COG0003	Pfam Anion-transporting ATPase
SYNGTI_RS13410	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SYNGTI_RS13415	COG0720	synthase
SYNGTI_RS13430	COG0328	RNA-DNA hybrid ribonuclease activity
SYNGTI_RS13435	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS13440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNGTI_RS13445	COG0513	Belongs to the DEAD box helicase family
SYNGTI_RS13450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SYNGTI_RS13455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SYNGTI_RS13460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SYNGTI_RS13465	COG0443	Heat shock 70 kDa protein
SYNGTI_RS13475	COG2226	methyltransferase
SYNGTI_RS13480	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SYNGTI_RS13485	COG1012	belongs to the aldehyde dehydrogenase family
SYNGTI_RS13490	COG1216	Glycosyl transferase, family 2
SYNGTI_RS13495	COG0484	heat shock protein binding
SYNGTI_RS13505	COG0659	secondary active sulfate transmembrane transporter activity
SYNGTI_RS13515	COG1131	(ABC) transporter
SYNGTI_RS13520	COG0131	Imidazoleglycerol-phosphate dehydratase
SYNGTI_RS13530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNGTI_RS13535	COG4251	negative regulation of phosphorylation
SYNGTI_RS13540	COG2197	response regulator
SYNGTI_RS13555	COG0515	serine threonine protein kinase
SYNGTI_RS13565	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_RS13580	COG0436	Aminotransferase
SYNGTI_RS13585	COG0586	Pfam SNARE associated Golgi protein
SYNGTI_RS13590	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SYNGTI_RS13590	COG3264	Mechanosensitive ion channel
SYNGTI_RS13605	COG0848	biopolymer transport protein
SYNGTI_RS13610	COG0848	biopolymer transport protein
SYNGTI_RS13615	COG0811	peptide transport
SYNGTI_RS13620	COG1840	ABC-type Fe3 transport system, periplasmic component
SYNGTI_RS13630	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_RS13635	COG2205	protein histidine kinase activity
SYNGTI_RS13645	COG0456	acetyltransferase
SYNGTI_RS13650	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYNGTI_RS13655	COG0047	phosphoribosylformylglycinamidine synthase activity
SYNGTI_RS13680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SYNGTI_RS13685	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SYNGTI_RS13690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SYNGTI_RS13695	COG0628	permease
SYNGTI_RS13710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNGTI_RS13715	COG0837	glucose binding
SYNGTI_RS13720	COG1132	(ABC) transporter
SYNGTI_RS13740	COG0668	transmembrane transport
SYNGTI_RS13745	COG1492	cobalamin metabolic process
SYNGTI_RS13765	COG0469	pyruvate kinase activity
SYNGTI_RS13770	COG2081	HI0933 family
SYNGTI_RS13775	COG3118	belongs to the thioredoxin family
SYNGTI_RS13790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SYNGTI_RS13805	COG0457	Tetratricopeptide repeat
SYNGTI_RS13805	COG0463	Glycosyl transferase, family 2
SYNGTI_RS13820	COG0004	ammonium transporteR
SYNGTI_RS13825	COG0800	Aldolase
SYNGTI_RS13835	COG1480	7TM receptor with intracellular HD hydrolase
SYNGTI_RS13840	COG2304	oxidoreductase activity
SYNGTI_RS13850	COG1192	Involved in chromosome partitioning
SYNGTI_RS13865	COG1473	amidohydrolase
SYNGTI_RS13875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SYNGTI_RS13900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNGTI_RS13905	COG0784	Response regulator, receiver
SYNGTI_RS13905	COG2205	protein histidine kinase activity
SYNGTI_RS13910	COG1192	Involved in chromosome partitioning
SYNGTI_RS13930	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS13950	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SYNGTI_RS13960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SYNGTI_RS13970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SYNGTI_RS13985	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SYNGTI_RS13990	COG2894	cell division
SYNGTI_RS13995	COG0850	regulation of cytokinetic process
SYNGTI_RS14000	COG1716	ATPase activity
SYNGTI_RS14015	COG0574	Belongs to the PEP-utilizing enzyme family
SYNGTI_RS14015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SYNGTI_RS14035	COG0398	Pfam SNARE associated Golgi protein
SYNGTI_RS14040	COG0737	Belongs to the 5'-nucleotidase family
SYNGTI_RS14045	COG0454	-acetyltransferase
SYNGTI_RS14060	COG1032	radical SAM domain protein
SYNGTI_RS14085	COG4585	Histidine kinase
SYNGTI_RS14090	COG2197	response regulator
SYNGTI_RS14095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SYNGTI_RS14095	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SYNGTI_RS14100	COG2267	carboxylic ester hydrolase activity
SYNGTI_RS14105	COG4221	oxidoreductase activity
SYNGTI_RS14140	COG0024	Methionine aminopeptidase
SYNGTI_RS14155	COG1051	belongs to the nudix hydrolase family
SYNGTI_RS14155	COG1056	cytidyltransferase-related domain
SYNGTI_RS14170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYNGTI_RS14175	COG5002	protein histidine kinase activity
SYNGTI_RS14200	COG2814	Major facilitator Superfamily
SYNGTI_RS14210	COG2217	Heavy metal translocating P-type atpase
SYNGTI_RS14215	COG1742	UPF0060 membrane protein
SYNGTI_RS14220	COG0640	Transcriptional regulator
SYNGTI_RS14225	COG2217	Heavy metal translocating P-type atpase
SYNGTI_RS14230	COG5002	protein histidine kinase activity
SYNGTI_RS14235	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS14255	COG2144	transferase activity, transferring acyl groups
SYNGTI_RS14280	COG2072	flavoprotein involved in K transport
SYNGTI_RS14285	COG2197	response regulator
SYNGTI_RS14300	COG2203	Gaf domain
SYNGTI_RS14300	COG3706	GGDEF domain
SYNGTI_RS14300	COG4251	negative regulation of phosphorylation
SYNGTI_RS14300	COG5001	Diguanylate cyclase
SYNGTI_RS14305	COG1131	(ABC) transporter
SYNGTI_RS14305	COG0842	Transport permease protein
SYNGTI_RS14305	COG1716	ATPase activity
SYNGTI_RS14315	COG0515	serine threonine protein kinase
SYNGTI_RS14315	COG3064	Membrane
SYNGTI_RS14315	COG4991	sh3 domain protein
SYNGTI_RS14335	COG2954	triphosphatase activity
SYNGTI_RS14350	COG0789	Transcriptional regulator
SYNGTI_RS14400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYNGTI_RS14405	COG0598	Magnesium transport protein CorA
SYNGTI_RS14420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYNGTI_RS14420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYNGTI_RS14455	COG0251	oxidation-reduction process
SYNGTI_RS14460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SYNGTI_RS14465	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SYNGTI_RS14470	COG0392	lysyltransferase activity
SYNGTI_RS14490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SYNGTI_RS14500	COG0343	queuine tRNA-ribosyltransferase activity
SYNGTI_RS14515	COG2886	Uncharacterised protein family (UPF0175)
SYNGTI_RS14520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYNGTI_RS14525	COG0668	transmembrane transport
SYNGTI_RS14530	COG0205	6-phosphofructokinase activity
SYNGTI_RS14550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYNGTI_RS14550	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYNGTI_RS14550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SYNGTI_RS14550	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYNGTI_RS14560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYNGTI_RS14565	COG0725	ABC transporter, periplasmic molybdate-binding protein
SYNGTI_RS14590	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_RS14605	COG0643	Histidine kinase
SYNGTI_RS14605	COG0784	Response regulator, receiver
SYNGTI_RS14605	COG2198	Histidine kinase
SYNGTI_RS14610	COG0840	transmembrane signaling receptor activity
SYNGTI_RS14615	COG2203	Gaf domain
SYNGTI_RS14615	COG0840	transmembrane signaling receptor activity
SYNGTI_RS14630	COG0784	Response regulator, receiver
SYNGTI_RS14640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYNGTI_RS14645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYNGTI_RS14650	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
SYNGTI_RS14655	COG1803	Methylglyoxal synthase
SYNGTI_RS14655	COG1597	lipid kinase activity
SYNGTI_RS14660	COG0436	Aminotransferase
SYNGTI_RS14685	COG0857	belongs to the CobB CobQ family
SYNGTI_RS14690	COG0583	DNA-binding transcription factor activity
SYNGTI_RS14695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYNGTI_RS14700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYNGTI_RS14705	COG3659	wide pore channel activity
SYNGTI_RS14710	COG1116	anion transmembrane transporter activity
SYNGTI_RS14710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYNGTI_RS14715	COG1116	anion transmembrane transporter activity
SYNGTI_RS14720	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_RS14725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYNGTI_RS14735	COG0724	RNA recognition motif
SYNGTI_RS14740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNGTI_RS14745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SYNGTI_RS14750	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SYNGTI_RS14755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYNGTI_RS14760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SYNGTI_RS14770	COG1653	transport
SYNGTI_RS14775	COG1175	transmembrane transport
SYNGTI_RS14780	COG0395	ABC-type sugar transport system, permease component
SYNGTI_RS14790	COG2205	protein histidine kinase activity
SYNGTI_RS14795	COG0741	lytic transglycosylase activity
SYNGTI_RS14805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SYNGTI_RS14820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SYNGTI_RS14825	COG0598	Magnesium transport protein CorA
SYNGTI_RS14830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SYNGTI_RS14835	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SYNGTI_RS14840	COG0019	diaminopimelate decarboxylase activity
SYNGTI_RS14845	COG1160	GTP binding
SYNGTI_RS14850	COG0018	arginyl-trna synthetase
SYNGTI_RS14855	COG0463	Glycosyl transferase, family 2
SYNGTI_RS14865	COG0740	serine-type endopeptidase activity
SYNGTI_RS14870	COG0133	tryptophan synthase activity
SYNGTI_RS14880	COG1136	(ABC) transporter
SYNGTI_RS14885	COG2314	TM2 domain
SYNGTI_RS14905	COG0017	Asparaginyl-tRNA synthetase
SYNGTI_RS14925	COG0569	domain protein
SYNGTI_RS14930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SYNGTI_RS14935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SYNGTI_RS14940	COG0629	single-stranded DNA binding
SYNGTI_RS14950	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYNGTI_RS14960	COG1192	Involved in chromosome partitioning
SYNGTI_RS14970	COG2119	membrane
SYNGTI_RS14975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SYNGTI_RS14980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SYNGTI_RS14990	COG1162	GTPase activity
SYNGTI_RS15000	COG0484	heat shock protein binding
SYNGTI_RS15005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SYNGTI_RS15010	COG1218	3'(2'),5'-bisphosphate nucleotidase
SYNGTI_RS15020	COG0134	indole-3-glycerol-phosphate synthase activity
SYNGTI_RS15025	COG0004	ammonium transporteR
SYNGTI_RS15030	COG0569	domain protein
SYNGTI_RS15035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SYNGTI_RS15040	COG0740	serine-type endopeptidase activity
SYNGTI_RS15045	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYNGTI_RS15050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SYNGTI_RS15055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SYNGTI_RS15060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SYNGTI_RS15070	COG0237	dephospho-CoA kinase activity
SYNGTI_RS15085	COG0517	IMP dehydrogenase activity
SYNGTI_RS15085	COG1994	Peptidase M50
SYNGTI_RS15090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SYNGTI_RS15110	COG0525	valine-tRNA ligase activity
SYNGTI_RS15115	COG0713	ATP synthesis coupled electron transport
SYNGTI_RS15120	COG0839	Belongs to the complex I subunit 6 family
SYNGTI_RS15125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_RS15130	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SYNGTI_RS15135	COG0167	dihydroorotate dehydrogenase activity
SYNGTI_RS15140	COG2166	iron-sulfur cluster assembly
SYNGTI_RS15145	COG1070	Carbohydrate kinase
SYNGTI_RS15165	COG0308	aminopeptidase N
SYNGTI_RS15170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYNGTI_RS15175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SYNGTI_RS15180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SYNGTI_RS15190	COG2193	ferroxidase activity
SYNGTI_RS15200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SYNGTI_RS15210	COG1834	amidinotransferase
SYNGTI_RS15215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNGTI_RS15245	COG0745	RESPONSE REGULATOR receiver
SYNGTI_RS15250	COG0483	inositol monophosphate 1-phosphatase activity
SYNGTI_RS15265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SYNGTI_RS15270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SYNGTI_RS15275	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SYNGTI_RS15280	COG4208	sulfate ABC transporter
SYNGTI_RS15285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYNGTI_RS15290	COG2165	general secretion pathway protein
SYNGTI_RS15305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYNGTI_RS15320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNGTI_RS15325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYNGTI_RS15330	COG0731	radical SAM domain protein
SYNGTI_RS15335	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SYNGTI_RS15340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SYNGTI_RS15350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SYNGTI_RS15355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SYNGTI_RS15370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNGTI_RS15425	COG0339	signal peptide processing
SYNGTI_RS15430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SYNGTI_RS15455	COG1166	arginine decarboxylase activity
SYNGTI_RS15465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SYNGTI_RS15485	COG1049	propionate catabolic process, 2-methylcitrate cycle
SYNGTI_RS15505	COG0070	glutamate synthase
SYNGTI_RS15505	COG0069	glutamate synthase activity
SYNGTI_RS15505	COG0067	glutamate synthase
SYNGTI_RS15510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SYNGTI_RS15515	COG0505	Belongs to the CarA family
SYNGTI_RS15525	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYNGTI_RS15530	COG0579	oxidoreductase
SYNGTI_RS15540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SYNGTI_RS15545	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SYNGTI_RS15550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SYNGTI_RS15555	COG3001	Fructosamine kinase
SYNGTI_RS15565	COG1191	sigma factor activity
SYNGTI_RS15570	COG0316	Belongs to the HesB IscA family
SYNGTI_RS15575	COG0463	Glycosyl transferase, family 2
SYNGTI_RS15580	COG2319	Wd-40 repeat
SYNGTI_RS15595	COG1691	(AIR) carboxylase
SYNGTI_RS15600	COG0739	heme binding
SYNGTI_RS15620	COG1496	oxidoreductase activity
SYNGTI_RS15625	COG2052	Domain of unknown function (DUF370)
SYNGTI_RS15630	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SYNGTI_RS15630	COG3264	Mechanosensitive ion channel
SYNGTI_RS15665	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SYNGTI_RS15680	COG0363	glucosamine-6-phosphate deaminase activity
SYNGTI_RS15700	COG5001	Diguanylate cyclase
SYNGTI_RS15700	COG2203	Gaf domain
SYNGTI_RS15700	COG4251	negative regulation of phosphorylation
SYNGTI_RS15700	COG3706	GGDEF domain
SYNGTI_RS15710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNGTI_RS15730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYNGTI_RS15735	COG5001	Diguanylate cyclase
SYNGTI_RS15735	COG3300	MHYT domain
SYNGTI_RS15745	COG3842	ATPase activity
SYNGTI_RS15755	COG1543	Belongs to the glycosyl hydrolase 57 family
SYNGTI_RS15765	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SYNGTI_RS15775	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYNGTI_RS15785	COG0457	Tetratricopeptide repeat
SYNGTI_RS15790	COG0148	phosphopyruvate hydratase activity
SYNGTI_RS15800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SYNGTI_RS15815	COG0825	malonyl-CoA metabolic process
SYNGTI_RS15840	COG1598	PFAM Uncharacterised protein family UPF0150
SYNGTI_RS15870	COG4251	negative regulation of phosphorylation
SYNGTI_RS15875	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SYNGTI_RS15900	COG2994	toxin metabolic process
SYNGTI_RS15925	COG0170	dolichyl monophosphate biosynthetic process
SYNGTI_RS15930	COG1473	amidohydrolase
SYNGTI_RS15935	COG3659	wide pore channel activity
SYNGTI_RS15955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYNGTI_RS15960	COG5001	Diguanylate cyclase
SYNGTI_RS15960	COG4251	negative regulation of phosphorylation
SYNGTI_RS15960	COG3706	GGDEF domain
SYNGTI_RS15960	COG2203	Gaf domain
SYNGTI_RS15985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SYNGTI_RS16015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SYNGTI_RS16030	COG2197	response regulator
SYNGTI_RS16075	COG2153	protein acetylation
SYNGTI_RS16125	COG4581	dead DEAH box helicase
SYNGTI_RS16135	COG0322	excinuclease ABC activity
SYNGTI_RS16140	COG0129	dihydroxy-acid dehydratase activity
SYNGTI_RS16145	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SYNGTI_RS16175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SYNGTI_RS16180	COG0546	phosphoglycolate phosphatase activity
SYNGTI_RS16210	COG0326	Molecular chaperone. Has ATPase activity
SYNGTI_RS16215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNGTI_RS16230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SYNGTI_RS16235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYNGTI_RS16245	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYNGTI_RS16275	COG0723	plastoquinol--plastocyanin reductase activity
SYNGTI_RS16290	COG1842	Phage shock protein A
SYNGTI_RS16310	COG1064	alcohol dehydrogenase
SYNGTI_RS16315	COG0137	argininosuccinate synthase activity
SYNGTI_RS16330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SYNGTI_RS16335	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_RS16355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNGTI_RS16370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SYNGTI_RS16375	COG0549	Belongs to the carbamate kinase family
SYNGTI_RS16390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNGTI_RS16395	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SYNGTI_RS16400	COG0577	efflux transmembrane transporter activity
SYNGTI_RS16400	COG1136	(ABC) transporter
SYNGTI_RS16405	COG0735	belongs to the Fur family
SYNGTI_RS16415	COG0138	bifunctional purine biosynthesis protein purh
SYNGTI_RS16435	COG0515	serine threonine protein kinase
SYNGTI_RS16460	COG0587	DNA-directed DNA polymerase activity
SYNGTI_RS16465	COG0481	GTPase activity
SYNGTI_RS16470	COG0435	Glutathione S-transferase
SYNGTI_RS16485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SYNGTI_RS16485	COG0140	phosphoribosyl-ATP diphosphatase activity
SYNGTI_RS16490	COG0523	cobalamin synthesis protein