locus-tag	class	description
IQE94_RS00010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IQE94_RS00015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IQE94_RS00025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IQE94_RS00030	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IQE94_RS00040	COG0731	radical SAM domain protein
IQE94_RS00045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IQE94_RS00055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IQE94_RS00060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IQE94_RS00065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IQE94_RS00070	COG0271	Belongs to the BolA IbaG family
IQE94_RS00105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IQE94_RS00135	COG0222	ribosome binding
IQE94_RS00145	COG2066	Belongs to the glutaminase family
IQE94_RS00160	COG0287	Prephenate dehydrogenase
IQE94_RS00165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IQE94_RS00180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IQE94_RS00185	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IQE94_RS00190	COG1333	cytochrome c biogenesis protein
IQE94_RS00200	COG0668	transmembrane transport
IQE94_RS00230	COG0436	Aminotransferase
IQE94_RS00235	COG0372	Belongs to the citrate synthase family
IQE94_RS00240	COG2062	phosphohistidine phosphatase, SixA
IQE94_RS00245	COG0596	Alpha beta hydrolase
IQE94_RS00260	COG1234	tRNA 3'-trailer cleavage
IQE94_RS00280	COG0788	formyltetrahydrofolate deformylase activity
IQE94_RS00300	COG0625	glutathione transferase activity
IQE94_RS00310	COG0440	acetolactate synthase activity
IQE94_RS00320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IQE94_RS00325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IQE94_RS00335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IQE94_RS00350	COG0628	permease
IQE94_RS00385	COG0628	permease
IQE94_RS00390	COG0443	Heat shock 70 kDa protein
IQE94_RS00395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IQE94_RS00405	COG0116	Belongs to the methyltransferase superfamily
IQE94_RS00415	COG0552	protein localization to endoplasmic reticulum
IQE94_RS00425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IQE94_RS00445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IQE94_RS00450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IQE94_RS00465	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IQE94_RS00475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IQE94_RS00480	COG0673	inositol 2-dehydrogenase activity
IQE94_RS00495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IQE94_RS00510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IQE94_RS00515	COG0114	fumarate hydratase activity
IQE94_RS00545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IQE94_RS00560	COG1253	flavin adenine dinucleotide binding
IQE94_RS00570	COG3046	protein related to deoxyribodipyrimidine photolyase
IQE94_RS00575	COG0517	IMP dehydrogenase activity
IQE94_RS00575	COG0617	tRNA 3'-terminal CCA addition
IQE94_RS00575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IQE94_RS00585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IQE94_RS00625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IQE94_RS00650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IQE94_RS00675	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IQE94_RS00680	COG4208	sulfate ABC transporter
IQE94_RS00685	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IQE94_RS00690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IQE94_RS00695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IQE94_RS00710	COG0483	inositol monophosphate 1-phosphatase activity
IQE94_RS00715	COG0745	RESPONSE REGULATOR receiver
IQE94_RS00735	COG4279	zinc finger
IQE94_RS00750	COG1834	amidinotransferase
IQE94_RS00760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IQE94_RS00770	COG2193	ferroxidase activity
IQE94_RS00780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IQE94_RS00785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IQE94_RS00790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IQE94_RS00875	COG0156	8-amino-7-oxononanoate synthase activity
IQE94_RS00880	COG0024	Methionine aminopeptidase
IQE94_RS00900	COG1178	ABC-type Fe3 transport system permease component
IQE94_RS00905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IQE94_RS00930	COG2197	response regulator
IQE94_RS00935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_RS00945	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_RS00960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IQE94_RS00960	COG0237	dephospho-CoA kinase activity
IQE94_RS00995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IQE94_RS01020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IQE94_RS01030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IQE94_RS01050	COG1446	asparaginase
IQE94_RS01055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IQE94_RS01060	COG0832	Belongs to the urease beta subunit family
IQE94_RS01065	COG2226	methyltransferase
IQE94_RS01105	COG0025	NhaP-type Na H and K H
IQE94_RS01115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IQE94_RS01140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IQE94_RS01160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IQE94_RS01200	COG3239	Fatty acid desaturase
IQE94_RS01210	COG1950	PFAM Membrane protein of
IQE94_RS01225	COG1253	flavin adenine dinucleotide binding
IQE94_RS01230	COG0228	four-way junction DNA binding
IQE94_RS01245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IQE94_RS01250	COG2010	Cytochrome c
IQE94_RS01265	COG0802	atpase or kinase
IQE94_RS01270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IQE94_RS01270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IQE94_RS01275	COG0497	DNA recombination
IQE94_RS01305	COG1429	ligase activity, forming nitrogen-metal bonds
IQE94_RS01325	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IQE94_RS01330	COG1136	(ABC) transporter
IQE94_RS01340	COG0133	tryptophan synthase activity
IQE94_RS01345	COG0740	serine-type endopeptidase activity
IQE94_RS01350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IQE94_RS01350	COG0519	Catalyzes the synthesis of GMP from XMP
IQE94_RS01355	COG0463	Glycosyl transferase, family 2
IQE94_RS01360	COG0018	arginyl-trna synthetase
IQE94_RS01365	COG1160	GTP binding
IQE94_RS01370	COG0019	diaminopimelate decarboxylase activity
IQE94_RS01375	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IQE94_RS01380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IQE94_RS01385	COG0598	Magnesium transport protein CorA
IQE94_RS01420	COG0717	Belongs to the dCTP deaminase family
IQE94_RS01425	COG0387	Pfam Sodium calcium exchanger
IQE94_RS01435	COG0052	Belongs to the universal ribosomal protein uS2 family
IQE94_RS01445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IQE94_RS01455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IQE94_RS01470	COG1160	GTP binding
IQE94_RS01480	COG0457	Tetratricopeptide repeat
IQE94_RS01485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IQE94_RS01490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IQE94_RS01495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IQE94_RS01540	COG2165	general secretion pathway protein
IQE94_RS01545	COG4968	Prepilin-type N-terminal cleavage methylation domain
IQE94_RS01555	COG4106	trans-aconitate 2-methyltransferase activity
IQE94_RS01560	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_RS01565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQE94_RS01570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IQE94_RS01585	COG2199	diguanylate cyclase activity
IQE94_RS01590	COG0750	zinc metalloprotease
IQE94_RS01595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IQE94_RS01605	COG0590	tRNA wobble adenosine to inosine editing
IQE94_RS01615	COG0415	Belongs to the DNA photolyase family
IQE94_RS01630	COG3429	Glucose-6-phosphate dehydrogenase subunit
IQE94_RS01630	COG3409	Peptidoglycan-binding domain 1 protein
IQE94_RS01640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IQE94_RS01675	COG0745	RESPONSE REGULATOR receiver
IQE94_RS01680	COG5002	protein histidine kinase activity
IQE94_RS01720	COG1122	ATPase activity
IQE94_RS01725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IQE94_RS01745	COG0070	glutamate synthase
IQE94_RS01745	COG0069	glutamate synthase activity
IQE94_RS01745	COG0067	glutamate synthase
IQE94_RS01755	COG0047	phosphoribosylformylglycinamidine synthase activity
IQE94_RS01760	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IQE94_RS01765	COG0456	acetyltransferase
IQE94_RS01775	COG2205	protein histidine kinase activity
IQE94_RS01785	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_RS01795	COG1840	ABC-type Fe3 transport system, periplasmic component
IQE94_RS01800	COG0811	peptide transport
IQE94_RS01815	COG0251	oxidation-reduction process
IQE94_RS01820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IQE94_RS01825	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IQE94_RS01830	COG0392	lysyltransferase activity
IQE94_RS01855	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IQE94_RS01865	COG0343	queuine tRNA-ribosyltransferase activity
IQE94_RS01885	COG2886	Uncharacterised protein family (UPF0175)
IQE94_RS01890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IQE94_RS01895	COG0668	transmembrane transport
IQE94_RS01900	COG0205	6-phosphofructokinase activity
IQE94_RS01915	COG0674	pyruvate-flavodoxin oxidoreductase activity
IQE94_RS01915	COG1013	pyruvate-flavodoxin oxidoreductase activity
IQE94_RS01915	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IQE94_RS01915	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IQE94_RS01925	COG3842	ATPase activity
IQE94_RS01930	COG0725	ABC transporter, periplasmic molybdate-binding protein
IQE94_RS01955	COG0438	transferase activity, transferring glycosyl groups
IQE94_RS01970	COG0643	Histidine kinase
IQE94_RS01970	COG0784	Response regulator, receiver
IQE94_RS01970	COG2198	Histidine kinase
IQE94_RS01980	COG2203	Gaf domain
IQE94_RS01980	COG0840	transmembrane signaling receptor activity
IQE94_RS01995	COG0784	Response regulator, receiver
IQE94_RS02005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IQE94_RS02010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IQE94_RS02015	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
IQE94_RS02020	COG1597	lipid kinase activity
IQE94_RS02020	COG1803	Methylglyoxal synthase
IQE94_RS02025	COG0436	Aminotransferase
IQE94_RS02110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IQE94_RS02155	COG0857	belongs to the CobB CobQ family
IQE94_RS02160	COG0583	DNA-binding transcription factor activity
IQE94_RS02165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IQE94_RS02170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IQE94_RS02175	COG3659	wide pore channel activity
IQE94_RS02180	COG1116	anion transmembrane transporter activity
IQE94_RS02180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IQE94_RS02185	COG1116	anion transmembrane transporter activity
IQE94_RS02240	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IQE94_RS02245	COG0571	ribonuclease III activity
IQE94_RS02265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IQE94_RS02270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IQE94_RS02285	COG0628	permease
IQE94_RS02290	COG0149	triose-phosphate isomerase activity
IQE94_RS02300	COG2205	protein histidine kinase activity
IQE94_RS02315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IQE94_RS02325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IQE94_RS02330	COG0450	alkyl hydroperoxide reductase
IQE94_RS02340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IQE94_RS02350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IQE94_RS02360	COG1131	(ABC) transporter
IQE94_RS02390	COG0439	Biotin carboxylase
IQE94_RS02415	COG0590	tRNA wobble adenosine to inosine editing
IQE94_RS02420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IQE94_RS02440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IQE94_RS02455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IQE94_RS02460	COG4251	negative regulation of phosphorylation
IQE94_RS02465	COG0784	Response regulator, receiver
IQE94_RS02470	COG1032	radical SAM domain protein
IQE94_RS02475	COG0167	dihydroorotate dehydrogenase activity
IQE94_RS02480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IQE94_RS02485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_RS02490	COG0839	Belongs to the complex I subunit 6 family
IQE94_RS02495	COG0713	ATP synthesis coupled electron transport
IQE94_RS02505	COG0525	valine-tRNA ligase activity
IQE94_RS02520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IQE94_RS02525	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IQE94_RS02550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IQE94_RS02555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IQE94_RS02560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IQE94_RS02570	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IQE94_RS02575	COG1716	ATPase activity
IQE94_RS02575	COG5001	Diguanylate cyclase
IQE94_RS02580	COG3631	Ketosteroid isomerase-related protein
IQE94_RS02590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IQE94_RS02590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IQE94_RS02600	COG0107	imidazoleglycerol-phosphate synthase activity
IQE94_RS02605	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IQE94_RS02610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IQE94_RS02615	COG0438	transferase activity, transferring glycosyl groups
IQE94_RS02670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IQE94_RS02675	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IQE94_RS02685	COG0514	ATP-dependent DNA helicase (RecQ)
IQE94_RS02700	COG0776	regulation of translation
IQE94_RS02715	COG0668	transmembrane transport
IQE94_RS02720	COG0668	transmembrane transport
IQE94_RS02740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IQE94_RS02740	COG1754	DNA topoisomerase type I activity
IQE94_RS02745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IQE94_RS02750	COG0640	Transcriptional regulator
IQE94_RS02755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IQE94_RS02770	COG2188	Transcriptional regulator
IQE94_RS02790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IQE94_RS02800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IQE94_RS02810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IQE94_RS02820	COG0831	urea catabolic process
IQE94_RS02825	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IQE94_RS02830	COG1562	ergosterol biosynthetic process
IQE94_RS02835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IQE94_RS02835	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IQE94_RS02865	COG2154	pterin-4-alpha-carbinolamine dehydratase
IQE94_RS02870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IQE94_RS02880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IQE94_RS02895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IQE94_RS02900	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IQE94_RS02905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IQE94_RS02960	COG1187	pseudouridine synthase activity
IQE94_RS02965	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IQE94_RS02995	COG1012	belongs to the aldehyde dehydrogenase family
IQE94_RS03000	COG3384	dioxygenase
IQE94_RS03015	COG3659	wide pore channel activity
IQE94_RS03020	COG0745	RESPONSE REGULATOR receiver
IQE94_RS03025	COG0860	N-Acetylmuramoyl-L-alanine amidase
IQE94_RS03025	COG2247	cell wall binding repeat
IQE94_RS03095	COG0768	penicillin binding
IQE94_RS03105	COG0247	lactate metabolic process
IQE94_RS03120	COG0583	DNA-binding transcription factor activity
IQE94_RS03130	COG0384	phenazine biosynthesis protein PhzF
IQE94_RS03140	COG0606	chelatase, subunit chli
IQE94_RS03150	COG0314	molybdopterin synthase activity
IQE94_RS03160	COG0315	cyclic pyranopterin monophosphate synthase activity
IQE94_RS03160	COG0746	molybdenum cofactor guanylyltransferase activity
IQE94_RS03165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IQE94_RS03170	COG0303	'Molybdopterin
IQE94_RS03175	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IQE94_RS03185	COG1480	7TM receptor with intracellular HD hydrolase
IQE94_RS03195	COG0800	Aldolase
IQE94_RS03200	COG0004	ammonium transporteR
IQE94_RS03205	COG3300	MHYT domain
IQE94_RS03205	COG5001	Diguanylate cyclase
IQE94_RS03230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IQE94_RS03245	COG0628	permease
IQE94_RS03260	COG0066	3-isopropylmalate dehydratase activity
IQE94_RS03265	COG0504	CTP synthase activity
IQE94_RS03275	COG2204	response regulator
IQE94_RS03285	COG0259	pyridoxamine-phosphate oxidase activity
IQE94_RS03300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IQE94_RS03320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IQE94_RS03325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IQE94_RS03335	COG0300	oxidoreductase activity
IQE94_RS03355	COG0798	PFAM Bile acid sodium symporter
IQE94_RS03360	COG0431	NADPH-dependent FMN reductase
IQE94_RS03365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IQE94_RS03425	COG1657	PFAM Prenyltransferase squalene oxidase
IQE94_RS03440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IQE94_RS03445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IQE94_RS03475	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IQE94_RS03500	COG4581	dead DEAH box helicase
IQE94_RS03530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IQE94_RS03545	COG0386	Belongs to the glutathione peroxidase family
IQE94_RS03550	COG2119	membrane
IQE94_RS03560	COG0371	Dehydrogenase
IQE94_RS03565	COG0644	oxidoreductase
IQE94_RS03595	COG2267	carboxylic ester hydrolase activity
IQE94_RS03605	COG3842	ATPase activity
IQE94_RS03610	COG1090	epimerase
IQE94_RS03635	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IQE94_RS03645	COG0275	rRNA processing
IQE94_RS03655	COG0793	Belongs to the peptidase S41A family
IQE94_RS03665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IQE94_RS03670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IQE94_RS03680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IQE94_RS03685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IQE94_RS03690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IQE94_RS03695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IQE94_RS03695	COG1116	anion transmembrane transporter activity
IQE94_RS03710	COG0243	molybdopterin cofactor binding
IQE94_RS03735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IQE94_RS03745	COG0242	peptide deformylase activity
IQE94_RS03750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IQE94_RS03765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IQE94_RS03770	COG1131	(ABC) transporter
IQE94_RS03780	COG0830	nickel cation binding
IQE94_RS03785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IQE94_RS03795	COG2010	Cytochrome c
IQE94_RS03820	COG0783	Belongs to the Dps family
IQE94_RS03825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IQE94_RS03830	COG0088	Forms part of the polypeptide exit tunnel
IQE94_RS03835	COG0089	rRNA binding
IQE94_RS03840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IQE94_RS03845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IQE94_RS03850	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IQE94_RS03855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IQE94_RS03860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IQE94_RS03865	COG0255	Belongs to the universal ribosomal protein uL29 family
IQE94_RS03870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IQE94_RS03875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IQE94_RS03880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IQE94_RS03885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IQE94_RS03890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IQE94_RS03895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IQE94_RS03900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IQE94_RS03905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IQE94_RS03910	COG0200	Binds to the 23S rRNA
IQE94_RS03915	COG0201	protein transport
IQE94_RS03920	COG0563	adenylate kinase activity
IQE94_RS03925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IQE94_RS03930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IQE94_RS03935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IQE94_RS03940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IQE94_RS03945	COG0202	RNA polymerase activity
IQE94_RS03950	COG0203	ribosomal protein L17
IQE94_RS03955	COG0101	tRNA pseudouridine synthase activity
IQE94_RS03960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IQE94_RS03965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IQE94_RS03970	COG0254	rRNA binding
IQE94_RS03980	COG3300	MHYT domain
IQE94_RS03980	COG5001	Diguanylate cyclase
IQE94_RS03990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IQE94_RS03995	COG5002	protein histidine kinase activity
IQE94_RS04000	COG1192	Involved in chromosome partitioning
IQE94_RS04015	COG0745	RESPONSE REGULATOR receiver
IQE94_RS04030	COG1612	heme a metabolic process
IQE94_RS04035	COG0109	protoheme IX farnesyltransferase activity
IQE94_RS04040	COG0298	carbon dioxide binding
IQE94_RS04065	COG1032	radical SAM domain protein
IQE94_RS04075	COG0359	binds to the 23S rRNA
IQE94_RS04080	COG2010	Cytochrome c
IQE94_RS04085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IQE94_RS04090	COG1672	PFAM Archaeal ATPase
IQE94_RS04095	COG3239	Fatty acid desaturase
IQE94_RS04100	COG0166	Belongs to the GPI family
IQE94_RS04105	COG1045	serine acetyltransferase
IQE94_RS04110	COG0288	reversible hydration of carbon dioxide
IQE94_RS04115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IQE94_RS04115	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IQE94_RS04150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IQE94_RS04160	COG1473	amidohydrolase
IQE94_RS04180	COG2304	oxidoreductase activity
IQE94_RS04190	COG2211	Major facilitator Superfamily
IQE94_RS04205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IQE94_RS04210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_RS04215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_RS04220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_RS04225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IQE94_RS04230	COG0037	tRNA processing
IQE94_RS04275	COG3659	wide pore channel activity
IQE94_RS04290	COG0405	Gamma-glutamyltransferase
IQE94_RS04295	COG0772	Belongs to the SEDS family
IQE94_RS04305	COG2192	nodulation
IQE94_RS04310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IQE94_RS04315	COG2274	protein secretion by the type I secretion system
IQE94_RS04320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IQE94_RS04325	COG0723	plastoquinol--plastocyanin reductase activity
IQE94_RS04340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IQE94_RS04380	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IQE94_RS04390	COG0784	Response regulator, receiver
IQE94_RS04395	COG0745	RESPONSE REGULATOR receiver
IQE94_RS04400	COG2203	Gaf domain
IQE94_RS04400	COG3706	GGDEF domain
IQE94_RS04400	COG4251	negative regulation of phosphorylation
IQE94_RS04400	COG5001	Diguanylate cyclase
IQE94_RS04420	COG3347	Dehydrogenase
IQE94_RS04420	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_RS04455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IQE94_RS04465	COG1175	transmembrane transport
IQE94_RS04480	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IQE94_RS04485	COG0450	alkyl hydroperoxide reductase
IQE94_RS04500	COG0393	Putative heavy-metal-binding
IQE94_RS04505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IQE94_RS04505	COG0758	DNA mediated transformation
IQE94_RS04525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IQE94_RS04535	COG1196	nuclear chromosome segregation
IQE94_RS04540	COG0113	porphobilinogen synthase activity
IQE94_RS04545	COG0803	Belongs to the bacterial solute-binding protein 9 family
IQE94_RS04550	COG1121	(ABC) transporter
IQE94_RS04555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IQE94_RS04560	COG0523	cobalamin synthesis protein
IQE94_RS04565	COG0302	gtp cyclohydrolase
IQE94_RS04590	COG0210	DNA helicase
IQE94_RS04600	COG5002	protein histidine kinase activity
IQE94_RS04605	COG0268	Binds directly to 16S ribosomal RNA
IQE94_RS04610	COG0084	hydrolase, TatD family'
IQE94_RS04615	COG0085	RNA polymerase activity
IQE94_RS04620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IQE94_RS04660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IQE94_RS04675	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IQE94_RS04685	COG0741	lytic transglycosylase activity
IQE94_RS04690	COG2205	protein histidine kinase activity
IQE94_RS04700	COG0395	ABC-type sugar transport system, permease component
IQE94_RS04705	COG1175	transmembrane transport
IQE94_RS04710	COG1653	transport
IQE94_RS04715	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IQE94_RS04720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IQE94_RS04730	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IQE94_RS04735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IQE94_RS04740	COG0724	RNA recognition motif
IQE94_RS04750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IQE94_RS04755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_RS04770	COG0151	Belongs to the GarS family
IQE94_RS04780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IQE94_RS04785	COG0049	tRNA binding
IQE94_RS04790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IQE94_RS04795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IQE94_RS04800	COG0051	transcription antitermination factor activity, RNA binding
IQE94_RS04815	COG1192	Involved in chromosome partitioning
IQE94_RS04825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IQE94_RS04840	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_RS04845	COG1619	proteins homologs of microcin C7 resistance protein MccF
IQE94_RS04855	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IQE94_RS04870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IQE94_RS04890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IQE94_RS04895	COG0222	ribosome binding
IQE94_RS04900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IQE94_RS04905	COG0081	regulation of translation
IQE94_RS04910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IQE94_RS04915	COG0250	Participates in transcription elongation, termination and antitermination
IQE94_RS04920	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IQE94_RS04930	COG0335	large ribosomal subunit rRNA binding
IQE94_RS04960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQE94_RS04970	COG3243	poly(R)-hydroxyalkanoic acid synthase
IQE94_RS04980	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IQE94_RS04990	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_RS04995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IQE94_RS05005	COG2885	chlorophyll binding
IQE94_RS05010	COG2885	chlorophyll binding
IQE94_RS05035	COG0022	dehydrogenase e1 component
IQE94_RS05035	COG0508	dehydrogenase complex catalyzes the overall conversion of
IQE94_RS05040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_RS05045	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_RS05050	COG1929	Belongs to the glycerate kinase type-1 family
IQE94_RS05055	COG3659	wide pore channel activity
IQE94_RS05065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IQE94_RS05085	COG0495	leucyl-tRNA aminoacylation
IQE94_RS05090	COG0786	glutamate:sodium symporter activity
IQE94_RS05120	COG1606	tRNA processing
IQE94_RS05130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IQE94_RS05135	COG2045	Belongs to the ComB family
IQE94_RS05140	COG0778	Nitroreductase
IQE94_RS05145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IQE94_RS05155	COG0516	GMP reductase activity
IQE94_RS05160	COG0395	ABC-type sugar transport system, permease component
IQE94_RS05185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IQE94_RS05185	COG0189	ligase activity
IQE94_RS05190	COG4242	Belongs to the peptidase S51 family
IQE94_RS05220	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_RS05225	COG0183	Belongs to the thiolase family
IQE94_RS05230	COG0386	Belongs to the glutathione peroxidase family
IQE94_RS05245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IQE94_RS05250	COG2264	protein methyltransferase activity
IQE94_RS05280	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IQE94_RS05280	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IQE94_RS05290	COG0438	transferase activity, transferring glycosyl groups
IQE94_RS05295	COG0488	(ABC) transporter
IQE94_RS05305	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IQE94_RS05325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IQE94_RS05330	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IQE94_RS05335	COG0561	phosphatase activity
IQE94_RS05340	COG1366	Belongs to the anti-sigma-factor antagonist family
IQE94_RS05345	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IQE94_RS05350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IQE94_RS05360	COG0215	cysteine-tRNA ligase activity
IQE94_RS05365	COG0424	maF-like protein
IQE94_RS05380	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
IQE94_RS05405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IQE94_RS05410	COG1799	cell septum assembly
IQE94_RS05415	COG0662	Cupin 2, conserved barrel domain protein
IQE94_RS05415	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IQE94_RS05425	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IQE94_RS05430	COG0459	protein refolding
IQE94_RS05440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IQE94_RS05450	COG2140	Oxalate decarboxylase
IQE94_RS05455	COG0058	SHG alpha-glucan phosphorylase activity
IQE94_RS05460	COG4658	electron transport chain
IQE94_RS05465	COG0515	serine threonine protein kinase
IQE94_RS05585	COG0305	Participates in initiation and elongation during chromosome replication
IQE94_RS05585	COG1372	Participates in initiation and elongation during chromosome replication
IQE94_RS05650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IQE94_RS05650	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IQE94_RS05655	COG4999	Histidine kinase
IQE94_RS05655	COG2205	protein histidine kinase activity
IQE94_RS05655	COG3850	Histidine kinase
IQE94_RS05655	COG3437	response regulator, receiver
IQE94_RS05690	COG0546	phosphoglycolate phosphatase activity
IQE94_RS05695	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IQE94_RS05700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IQE94_RS05715	COG0501	Belongs to the peptidase M48B family
IQE94_RS05720	COG0539	negative regulation of cytoplasmic translation
IQE94_RS05725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IQE94_RS05730	COG1132	(ABC) transporter
IQE94_RS05735	COG0469	pyruvate kinase activity
IQE94_RS05755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IQE94_RS05760	COG1268	BioY protein
IQE94_RS05765	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IQE94_RS05790	COG1104	cysteine desulfurase activity
IQE94_RS05800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IQE94_RS05805	COG1061	Type III restriction enzyme res subunit
IQE94_RS05815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IQE94_RS05815	COG0519	Catalyzes the synthesis of GMP from XMP
IQE94_RS05835	COG1492	cobalamin metabolic process
IQE94_RS05840	COG0025	NhaP-type Na H and K H
IQE94_RS05845	COG0583	DNA-binding transcription factor activity
IQE94_RS05885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IQE94_RS05895	COG5398	heme oxygenase
IQE94_RS05900	COG0408	coproporphyrinogen oxidase activity
IQE94_RS05910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IQE94_RS05940	COG0277	FAD linked oxidase domain protein
IQE94_RS05945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IQE94_RS05975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IQE94_RS05980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IQE94_RS05990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IQE94_RS06005	COG1555	photosystem II stabilization
IQE94_RS06010	COG1289	transmembrane transporter activity
IQE94_RS06015	COG0205	6-phosphofructokinase activity
IQE94_RS06025	COG0336	Belongs to the RNA methyltransferase TrmD family
IQE94_RS06030	COG1840	ABC-type Fe3 transport system, periplasmic component
IQE94_RS06050	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_RS06075	COG4636	protein conserved in cyanobacteria
IQE94_RS06080	COG0538	isocitrate dehydrogenase activity
IQE94_RS06090	COG2226	methyltransferase
IQE94_RS06095	COG0589	response to stress
IQE94_RS06125	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IQE94_RS06155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IQE94_RS06240	COG0375	protein maturation
IQE94_RS06255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IQE94_RS06260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IQE94_RS06265	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IQE94_RS06275	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IQE94_RS06285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IQE94_RS06305	COG0312	modulator of DNA gyrase
IQE94_RS06315	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IQE94_RS06335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IQE94_RS06355	COG0189	ligase activity
IQE94_RS06360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IQE94_RS06370	COG2267	carboxylic ester hydrolase activity
IQE94_RS06385	COG0402	S-adenosylhomocysteine deaminase activity
IQE94_RS06415	COG0537	adenosine 5'-monophosphoramidase activity
IQE94_RS06440	COG1233	COG1233 Phytoene dehydrogenase and related
IQE94_RS06445	COG0589	response to stress
IQE94_RS06450	COG0659	secondary active sulfate transmembrane transporter activity
IQE94_RS06455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IQE94_RS06460	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IQE94_RS06465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IQE94_RS06475	COG0515	serine threonine protein kinase
IQE94_RS06485	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IQE94_RS06515	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQE94_RS06525	COG0747	negative chemotaxis
IQE94_RS06535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IQE94_RS06540	COG0596	Alpha beta hydrolase
IQE94_RS06550	COG0616	signal peptide processing
IQE94_RS06560	COG2203	Gaf domain
IQE94_RS06560	COG3706	GGDEF domain
IQE94_RS06560	COG5001	Diguanylate cyclase
IQE94_RS06560	COG4251	negative regulation of phosphorylation
IQE94_RS06565	COG2197	response regulator
IQE94_RS06595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IQE94_RS06620	COG2886	Uncharacterised protein family (UPF0175)
IQE94_RS06640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IQE94_RS06655	COG0443	Heat shock 70 kDa protein
IQE94_RS06665	COG0646	methionine synthase
IQE94_RS06665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IQE94_RS06685	COG0187	DNA topoisomerase II activity
IQE94_RS06685	COG1372	Participates in initiation and elongation during chromosome replication
IQE94_RS06700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IQE94_RS06710	COG0612	Peptidase, M16
IQE94_RS06715	COG0612	Peptidase, M16
IQE94_RS06720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IQE94_RS06725	COG0602	queuosine metabolic process
IQE94_RS06730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQE94_RS06740	COG1489	DNA binding
IQE94_RS06750	COG0280	phosphate acetyltransferase
IQE94_RS06750	COG0857	belongs to the CobB CobQ family
IQE94_RS06755	COG0427	acetyl-CoA hydrolase
IQE94_RS06760	COG0181	hydroxymethylbilane synthase activity
IQE94_RS06770	COG0799	negative regulation of ribosome biogenesis
IQE94_RS06785	COG0180	Tryptophanyl-tRNA synthetase
IQE94_RS06805	COG0196	riboflavin kinase activity
IQE94_RS06815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_RS06820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IQE94_RS06830	COG0083	homoserine kinase activity
IQE94_RS06870	COG0641	radical SAM
IQE94_RS06875	COG1413	lyase activity
IQE94_RS06880	COG0179	Fumarylacetoacetate (FAA) hydrolase
IQE94_RS06885	COG0360	Binds together with S18 to 16S ribosomal RNA
IQE94_RS06895	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IQE94_RS06900	COG3932	Exopolysaccharide synthesis, ExoD
IQE94_RS06905	COG1181	Belongs to the D-alanine--D-alanine ligase family
IQE94_RS06925	COG3937	granule-associated protein
IQE94_RS06940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IQE94_RS06945	COG0631	protein serine/threonine phosphatase activity
IQE94_RS06950	COG1193	negative regulation of DNA recombination
IQE94_RS06960	COG1741	Belongs to the pirin family
IQE94_RS06995	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IQE94_RS07000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IQE94_RS07035	COG2208	phosphoserine phosphatase activity
IQE94_RS07035	COG2770	Histidine kinase
IQE94_RS07050	COG1366	Belongs to the anti-sigma-factor antagonist family
IQE94_RS07095	COG1082	Xylose isomerase domain protein TIM barrel
IQE94_RS07115	COG2319	Wd-40 repeat
IQE94_RS07120	COG2319	Wd-40 repeat
IQE94_RS07135	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_RS07140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IQE94_RS07165	COG0723	plastoquinol--plastocyanin reductase activity
IQE94_RS07170	COG3258	Cytochrome c
IQE94_RS07180	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IQE94_RS07205	COG0322	excinuclease ABC activity
IQE94_RS07215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IQE94_RS07230	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_RS07235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IQE94_RS07310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IQE94_RS07315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IQE94_RS07325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IQE94_RS07340	COG1316	TRANSCRIPTIONal
IQE94_RS07360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IQE94_RS07385	COG0509	glycine decarboxylation via glycine cleavage system
IQE94_RS07390	COG0739	heme binding
IQE94_RS07395	COG0154	amidase activity
IQE94_RS07400	COG0724	RNA recognition motif
IQE94_RS07415	COG0632	four-way junction helicase activity
IQE94_RS07420	COG1970	mechanosensitive ion channel activity
IQE94_RS07440	COG0575	Belongs to the CDS family
IQE94_RS07450	COG0058	SHG alpha-glucan phosphorylase activity
IQE94_RS07460	COG0765	amino acid transport
IQE94_RS07465	COG3659	wide pore channel activity
IQE94_RS07470	COG5001	Diguanylate cyclase
IQE94_RS07470	COG3300	MHYT domain
IQE94_RS07490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IQE94_RS07495	COG0443	Heat shock 70 kDa protein
IQE94_RS07500	COG0484	heat shock protein binding
IQE94_RS07520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IQE94_RS07535	COG1702	phosphate starvation-inducible protein PhoH
IQE94_RS07550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IQE94_RS07555	COG1121	(ABC) transporter
IQE94_RS07590	COG3228	Belongs to the MtfA family
IQE94_RS07595	COG0784	Response regulator, receiver
IQE94_RS07600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IQE94_RS07635	COG2319	Wd-40 repeat
IQE94_RS07640	COG1587	Uroporphyrinogen-III synthase
IQE94_RS07660	COG0443	Heat shock 70 kDa protein
IQE94_RS07665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IQE94_RS07670	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IQE94_RS07685	COG1937	Protein conserved in bacteria
IQE94_RS07695	COG0516	GMP reductase activity
IQE94_RS07695	COG0517	IMP dehydrogenase activity
IQE94_RS07710	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_RS07745	COG2205	protein histidine kinase activity
IQE94_RS07745	COG2202	Pas domain
IQE94_RS07760	COG4783	chaperone-mediated protein folding
IQE94_RS07765	COG2205	protein histidine kinase activity
IQE94_RS07765	COG3437	response regulator, receiver
IQE94_RS07765	COG3850	Histidine kinase
IQE94_RS07765	COG4999	Histidine kinase
IQE94_RS07775	COG4956	integral membrane protein (PIN domain superfamily)
IQE94_RS07790	COG1160	GTP binding
IQE94_RS07800	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IQE94_RS07815	COG0432	Pfam Uncharacterised protein family UPF0047
IQE94_RS07820	COG2197	response regulator
IQE94_RS07835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IQE94_RS07840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IQE94_RS07850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IQE94_RS07855	COG5398	heme oxygenase
IQE94_RS07860	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IQE94_RS07870	COG1316	TRANSCRIPTIONal
IQE94_RS07885	COG2208	phosphoserine phosphatase activity
IQE94_RS07885	COG2770	Histidine kinase
IQE94_RS07890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IQE94_RS07900	COG0539	negative regulation of cytoplasmic translation
IQE94_RS07905	COG0358	DNA primase activity
IQE94_RS07915	COG0009	L-threonylcarbamoyladenylate synthase
IQE94_RS07935	COG0589	response to stress
IQE94_RS07950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IQE94_RS07970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IQE94_RS07975	COG0594	ribonuclease P activity
IQE94_RS07985	COG0706	membrane insertase activity
IQE94_RS07995	COG0484	heat shock protein binding
IQE94_RS08000	COG0483	inositol monophosphate 1-phosphatase activity
IQE94_RS08005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQE94_RS08020	COG0791	NLP P60 protein
IQE94_RS08040	COG0540	Belongs to the ATCase OTCase family
IQE94_RS08070	COG1215	transferase activity, transferring glycosyl groups
IQE94_RS08095	COG0300	oxidoreductase activity
IQE94_RS08095	COG3000	fatty acid hydroxylase
IQE94_RS08115	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IQE94_RS08120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQE94_RS08125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IQE94_RS08130	COG0463	Glycosyl transferase, family 2
IQE94_RS08135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IQE94_RS08150	COG1472	Belongs to the glycosyl hydrolase 3 family
IQE94_RS08160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IQE94_RS08165	COG1280	lysine exporter protein (LysE YggA)
IQE94_RS08180	COG0564	pseudouridine synthase activity
IQE94_RS08190	COG0438	transferase activity, transferring glycosyl groups
IQE94_RS08230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IQE94_RS08255	COG0500	methyltransferase
IQE94_RS08260	COG0542	response to heat
IQE94_RS08270	COG0572	uridine kinase
IQE94_RS08285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IQE94_RS08290	COG0561	phosphatase activity
IQE94_RS08305	COG0571	ribonuclease III activity
IQE94_RS08310	COG0390	transport system, permease component
IQE94_RS08315	COG0668	transmembrane transport
IQE94_RS08320	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
IQE94_RS08330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IQE94_RS08335	COG0426	domain, Protein
IQE94_RS08335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IQE94_RS08345	COG0126	phosphoglycerate kinase activity
IQE94_RS08350	COG0583	DNA-binding transcription factor activity
IQE94_RS08355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IQE94_RS08395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IQE94_RS08410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IQE94_RS08415	COG0347	Belongs to the P(II) protein family
IQE94_RS08430	COG0135	phosphoribosylanthranilate isomerase activity
IQE94_RS08435	COG0697	spore germination
IQE94_RS08445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IQE94_RS08460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IQE94_RS08465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IQE94_RS08475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IQE94_RS08510	COG0310	cobalt ion transport
IQE94_RS08520	COG1122	ATPase activity
IQE94_RS08530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IQE94_RS08540	COG0589	response to stress
IQE94_RS08540	COG0475	glutathione-regulated potassium exporter activity
IQE94_RS08550	COG0406	alpha-ribazole phosphatase activity
IQE94_RS08555	COG0745	RESPONSE REGULATOR receiver
IQE94_RS08565	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IQE94_RS08575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IQE94_RS08605	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IQE94_RS08610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IQE94_RS08625	COG2211	Major facilitator Superfamily
IQE94_RS08645	COG5002	protein histidine kinase activity
IQE94_RS08655	COG0752	glycyl-tRNA synthetase alpha subunit
IQE94_RS08670	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IQE94_RS08680	COG0354	folic acid binding
IQE94_RS08685	COG0583	DNA-binding transcription factor activity
IQE94_RS08715	COG0697	spore germination
IQE94_RS08745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IQE94_RS08755	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IQE94_RS08760	COG3339	Conserved Protein
IQE94_RS08770	COG0312	modulator of DNA gyrase
IQE94_RS08775	COG0482	sulfurtransferase activity
IQE94_RS08790	COG0488	(ABC) transporter
IQE94_RS08805	COG0284	orotidine-5'-phosphate decarboxylase activity
IQE94_RS08855	COG1132	(ABC) transporter
IQE94_RS08865	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IQE94_RS08870	COG2084	Dehydrogenase
IQE94_RS08880	COG0805	protein transport
IQE94_RS08885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IQE94_RS08890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IQE94_RS08900	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IQE94_RS08910	COG0445	tRNA wobble uridine modification
IQE94_RS08920	COG3794	PFAM blue (type 1) copper domain protein
IQE94_RS08930	COG1234	tRNA 3'-trailer cleavage
IQE94_RS08965	COG0010	Belongs to the arginase family
IQE94_RS08970	COG0375	protein maturation
IQE94_RS08985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IQE94_RS08990	COG1116	anion transmembrane transporter activity
IQE94_RS08995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IQE94_RS09000	COG3118	belongs to the thioredoxin family
IQE94_RS09005	COG1845	cytochrome c oxidase, subunit III
IQE94_RS09010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IQE94_RS09015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IQE94_RS09035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IQE94_RS09050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IQE94_RS09050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IQE94_RS09080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IQE94_RS09100	COG2046	Belongs to the sulfate adenylyltransferase family
IQE94_RS09105	COG0438	transferase activity, transferring glycosyl groups
IQE94_RS09120	COG0737	Belongs to the 5'-nucleotidase family
IQE94_RS09135	COG2361	Protein of unknown function DUF86
IQE94_RS09145	COG2361	Protein of unknown function DUF86
IQE94_RS09170	COG1487	ribonuclease activity
IQE94_RS09180	COG4115	mRNA cleavage
IQE94_RS09215	COG0069	glutamate synthase activity
IQE94_RS09215	COG0070	glutamate synthase
IQE94_RS09215	COG0067	glutamate synthase
IQE94_RS09235	COG2133	pyrroloquinoline quinone binding
IQE94_RS09240	COG1797	cobyrinic acid a,c-diamide synthase activity
IQE94_RS09245	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IQE94_RS09250	COG1022	Amp-dependent synthetase and ligase
IQE94_RS09255	COG0784	Response regulator, receiver
IQE94_RS09270	COG2203	Gaf domain
IQE94_RS09270	COG0840	transmembrane signaling receptor activity
IQE94_RS09275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IQE94_RS09280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IQE94_RS09285	COG2203	Gaf domain
IQE94_RS09285	COG5001	Diguanylate cyclase
IQE94_RS09285	COG4251	negative regulation of phosphorylation
IQE94_RS09285	COG3706	GGDEF domain
IQE94_RS09295	COG0419	ATPase involved in DNA repair
IQE94_RS09300	COG0484	heat shock protein binding
IQE94_RS09305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IQE94_RS09315	COG2314	TM2 domain
IQE94_RS09340	COG0017	Asparaginyl-tRNA synthetase
IQE94_RS09360	COG0569	domain protein
IQE94_RS09365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IQE94_RS09370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IQE94_RS09375	COG0629	single-stranded DNA binding
IQE94_RS09385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IQE94_RS09395	COG1192	Involved in chromosome partitioning
IQE94_RS09405	COG2119	membrane
IQE94_RS09410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IQE94_RS09415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IQE94_RS09425	COG1162	GTPase activity
IQE94_RS09435	COG0484	heat shock protein binding
IQE94_RS09440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IQE94_RS09445	COG1218	3'(2'),5'-bisphosphate nucleotidase
IQE94_RS09450	COG0134	indole-3-glycerol-phosphate synthase activity
IQE94_RS09455	COG0004	ammonium transporteR
IQE94_RS09460	COG0569	domain protein
IQE94_RS09465	COG0675	Transposase, IS605 OrfB family
IQE94_RS09480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IQE94_RS09485	COG0740	serine-type endopeptidase activity
IQE94_RS09490	COG0544	peptidyl-prolyl cis-trans isomerase activity
IQE94_RS09495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IQE94_RS09500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IQE94_RS09505	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IQE94_RS09515	COG0237	dephospho-CoA kinase activity
IQE94_RS09530	COG1234	tRNA 3'-trailer cleavage
IQE94_RS09540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IQE94_RS09555	COG0631	protein serine/threonine phosphatase activity
IQE94_RS09560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IQE94_RS09570	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IQE94_RS09575	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_RS09580	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_RS09585	COG0493	'glutamate synthase
IQE94_RS09590	COG3659	wide pore channel activity
IQE94_RS09615	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
IQE94_RS09615	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
IQE94_RS09645	COG1982	Orn Lys Arg decarboxylase major
IQE94_RS09655	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IQE94_RS09675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IQE94_RS09680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IQE94_RS09685	COG0745	RESPONSE REGULATOR receiver
IQE94_RS09690	COG0673	inositol 2-dehydrogenase activity
IQE94_RS09695	COG0700	Nucleoside recognition
IQE94_RS09700	COG2715	membrane protein required for spore maturation
IQE94_RS09705	COG1640	4-alpha-glucanotransferase
IQE94_RS09715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IQE94_RS09720	COG4251	negative regulation of phosphorylation
IQE94_RS09720	COG3706	GGDEF domain
IQE94_RS09720	COG2203	Gaf domain
IQE94_RS09720	COG5001	Diguanylate cyclase
IQE94_RS09725	COG0784	Response regulator, receiver
IQE94_RS09725	COG2205	protein histidine kinase activity
IQE94_RS09740	COG1981	membrane
IQE94_RS09745	COG0175	sulfate reduction
IQE94_RS09750	COG1420	regulation of RNA biosynthetic process
IQE94_RS09760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IQE94_RS09765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IQE94_RS09775	COG0003	Pfam Anion-transporting ATPase
IQE94_RS09780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IQE94_RS09795	COG0484	heat shock protein binding
IQE94_RS09800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IQE94_RS09820	COG0077	Prephenate dehydratase
IQE94_RS09820	COG1605	Chorismate mutase
IQE94_RS09830	COG4251	negative regulation of phosphorylation
IQE94_RS09830	COG3706	GGDEF domain
IQE94_RS09830	COG2203	Gaf domain
IQE94_RS09830	COG5001	Diguanylate cyclase
IQE94_RS09850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IQE94_RS09855	COG1595	DNA-templated transcription, initiation
IQE94_RS09870	COG0415	Belongs to the DNA photolyase family
IQE94_RS09895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IQE94_RS09905	COG1252	NADH dehydrogenase
IQE94_RS09945	COG0678	peroxiredoxin activity
IQE94_RS09970	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IQE94_RS09990	COG2205	protein histidine kinase activity
IQE94_RS09995	COG2890	protein-(glutamine-N5) methyltransferase activity
IQE94_RS10000	COG0312	modulator of DNA gyrase
IQE94_RS10020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IQE94_RS10030	COG0113	porphobilinogen synthase activity
IQE94_RS10070	COG0463	Glycosyl transferase, family 2
IQE94_RS10085	COG1442	glycosyl transferase family 8
IQE94_RS10100	COG0500	methyltransferase
IQE94_RS10125	COG3385	transposase activity
IQE94_RS10135	COG2226	methyltransferase
IQE94_RS10145	COG4115	mRNA cleavage
IQE94_RS10150	COG2161	toxin-antitoxin pair type II binding
IQE94_RS10175	COG0629	single-stranded DNA binding
IQE94_RS10180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IQE94_RS10185	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
IQE94_RS10195	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IQE94_RS10220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IQE94_RS10260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IQE94_RS10265	COG2319	Wd-40 repeat
IQE94_RS10270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IQE94_RS10280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IQE94_RS10300	COG0095	Lipoate-protein ligase
IQE94_RS10305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IQE94_RS10310	COG0656	L-ascorbic acid biosynthetic process
IQE94_RS10320	COG1575	Belongs to the MenA family. Type 1 subfamily
IQE94_RS10330	COG0473	3-isopropylmalate dehydrogenase activity
IQE94_RS10335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IQE94_RS10340	COG3063	Type IV pilus biogenesis stability protein PilW
IQE94_RS10360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IQE94_RS10365	COG0347	Belongs to the P(II) protein family
IQE94_RS10380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IQE94_RS10385	COG0416	fatty acid biosynthetic process
IQE94_RS10395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IQE94_RS10400	COG0438	transferase activity, transferring glycosyl groups
IQE94_RS10430	COG0454	-acetyltransferase
IQE94_RS10445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IQE94_RS10460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IQE94_RS10465	COG1247	-acetyltransferase
IQE94_RS10470	COG0174	glutamine synthetase
IQE94_RS10480	COG2203	Gaf domain
IQE94_RS10480	COG4251	negative regulation of phosphorylation
IQE94_RS10480	COG5001	Diguanylate cyclase
IQE94_RS10480	COG3706	GGDEF domain
IQE94_RS10490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IQE94_RS10505	COG0076	glutamate decarboxylase activity
IQE94_RS10520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IQE94_RS10525	COG0829	nickel cation binding
IQE94_RS10545	COG1045	serine acetyltransferase
IQE94_RS10565	COG0412	Dienelactone hydrolase
IQE94_RS10570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IQE94_RS10575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IQE94_RS10580	COG1294	oxidase, subunit
IQE94_RS10585	COG1271	oxidase subunit
IQE94_RS10595	COG0681	Belongs to the peptidase S26 family
IQE94_RS10605	COG2226	methyltransferase
IQE94_RS10620	COG3937	granule-associated protein
IQE94_RS10625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IQE94_RS10625	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IQE94_RS10630	COG0745	RESPONSE REGULATOR receiver
IQE94_RS10640	COG0668	transmembrane transport
IQE94_RS10650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IQE94_RS10665	COG0438	transferase activity, transferring glycosyl groups
IQE94_RS10675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IQE94_RS10675	COG2205	protein histidine kinase activity
IQE94_RS10680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IQE94_RS10685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IQE94_RS10695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IQE94_RS10700	COG3259	Nickel-dependent hydrogenase
IQE94_RS10715	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
IQE94_RS10720	COG1034	ATP synthesis coupled electron transport
IQE94_RS10745	COG0409	Hydrogenase expression formation protein
IQE94_RS10755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IQE94_RS10760	COG0297	glycogen (starch) synthase activity
IQE94_RS10775	COG1131	(ABC) transporter
IQE94_RS10790	COG0668	transmembrane transport
IQE94_RS10825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IQE94_RS10830	COG1121	(ABC) transporter
IQE94_RS10835	COG0803	Belongs to the bacterial solute-binding protein 9 family
IQE94_RS10870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IQE94_RS10885	COG0163	prenyltransferase activity
IQE94_RS10895	COG0589	response to stress
IQE94_RS10900	COG5001	Diguanylate cyclase
IQE94_RS10900	COG1716	ATPase activity
IQE94_RS10905	COG1716	ATPase activity
IQE94_RS10905	COG5001	Diguanylate cyclase
IQE94_RS10915	COG1217	gtp-binding protein TYPA
IQE94_RS10935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IQE94_RS10945	COG0442	prolyl-tRNA aminoacylation
IQE94_RS10955	COG4372	Transposase
IQE94_RS10960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IQE94_RS10975	COG3588	fructose-bisphosphate aldolase
IQE94_RS10980	COG0656	L-ascorbic acid biosynthetic process
IQE94_RS10985	COG0784	Response regulator, receiver
IQE94_RS10985	COG4191	Histidine kinase
IQE94_RS11000	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_RS11010	COG2816	NAD+ diphosphatase activity
IQE94_RS11015	COG0165	Argininosuccinate lyase
IQE94_RS11025	COG2208	phosphoserine phosphatase activity
IQE94_RS11045	COG0438	transferase activity, transferring glycosyl groups
IQE94_RS11050	COG0557	exoribonuclease II activity
IQE94_RS11080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IQE94_RS11090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IQE94_RS11095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IQE94_RS11105	COG0745	RESPONSE REGULATOR receiver
IQE94_RS11110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IQE94_RS11115	COG2217	Heavy metal translocating P-type atpase
IQE94_RS11125	COG3063	Type IV pilus biogenesis stability protein PilW
IQE94_RS11130	COG1132	(ABC) transporter
IQE94_RS11190	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_RS11195	COG1006	Multisubunit Na H antiporter MnhC subunit
IQE94_RS11230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IQE94_RS11245	COG0587	DNA-directed DNA polymerase activity
IQE94_RS11250	COG0739	heme binding
IQE94_RS11260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IQE94_RS11265	COG2988	succinylglutamate desuccinylase activity
IQE94_RS11275	COG0515	serine threonine protein kinase
IQE94_RS11305	COG0237	dephospho-CoA kinase activity
IQE94_RS11310	COG0237	dephospho-CoA kinase activity
IQE94_RS11315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IQE94_RS11320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IQE94_RS11335	COG1596	polysaccharide export
IQE94_RS11345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IQE94_RS11350	COG3411	Ferredoxin
IQE94_RS11360	COG2385	sporulation resulting in formation of a cellular spore
IQE94_RS11370	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IQE94_RS11405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IQE94_RS11410	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IQE94_RS11415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IQE94_RS11420	COG0628	permease
IQE94_RS11435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IQE94_RS11440	COG0837	glucose binding
IQE94_RS11445	COG1132	(ABC) transporter
IQE94_RS11475	COG5002	protein histidine kinase activity
IQE94_RS11480	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
IQE94_RS11490	COG1309	transcriptional regulator
IQE94_RS11515	COG0024	Methionine aminopeptidase
IQE94_RS11520	COG4221	oxidoreductase activity
IQE94_RS11545	COG0625	glutathione transferase activity
IQE94_RS11570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IQE94_RS11575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IQE94_RS11585	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IQE94_RS11590	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IQE94_RS11640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IQE94_RS11640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IQE94_RS11650	COG0612	Peptidase, M16
IQE94_RS11655	COG0489	protein tyrosine kinase activity
IQE94_RS11660	COG0505	Belongs to the CarA family
IQE94_RS11670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IQE94_RS11695	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IQE94_RS11700	COG0006	proline dipeptidase activity
IQE94_RS11705	COG0740	serine-type endopeptidase activity
IQE94_RS11710	COG0740	serine-type endopeptidase activity
IQE94_RS11795	COG1459	type II secretion system
IQE94_RS11825	COG0542	response to heat
IQE94_RS11835	COG0528	UMP kinase activity
IQE94_RS11840	COG0233	cytoplasmic translational termination
IQE94_RS11855	COG3268	Saccharopine dehydrogenase
IQE94_RS11880	COG1410	methionine synthase
IQE94_RS11880	COG0646	methionine synthase
IQE94_RS11880	COG0646	methionine synthase
IQE94_RS11880	COG1410	methionine synthase
IQE94_RS11920	COG0646	methionine synthase
IQE94_RS11920	COG1410	methionine synthase
IQE94_RS11925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IQE94_RS11940	COG2205	protein histidine kinase activity
IQE94_RS11940	COG2202	Pas domain
IQE94_RS11965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IQE94_RS11975	COG0824	Thioesterase
IQE94_RS11985	COG4178	(ABC) transporter
IQE94_RS12000	COG0762	integral membrane protein
IQE94_RS12005	COG2048	Heterodisulfide reductase, subunit B
IQE94_RS12015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQE94_RS12020	COG0121	glutamine amidotransferase
IQE94_RS12030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IQE94_RS12045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IQE94_RS12055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IQE94_RS12060	COG2247	cell wall binding repeat
IQE94_RS12060	COG2385	sporulation resulting in formation of a cellular spore
IQE94_RS12070	COG0792	nuclease activity
IQE94_RS12075	COG1058	Belongs to the CinA family
IQE94_RS12075	COG1546	Belongs to the CinA family
IQE94_RS12080	COG0302	gtp cyclohydrolase
IQE94_RS12085	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IQE94_RS12095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IQE94_RS12110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IQE94_RS12145	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IQE94_RS12165	COG0105	UTP biosynthetic process
IQE94_RS12185	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IQE94_RS12195	COG0501	Belongs to the peptidase M48B family
IQE94_RS12225	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IQE94_RS12235	COG0463	Glycosyl transferase, family 2
IQE94_RS12245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IQE94_RS12260	COG0508	dehydrogenase complex catalyzes the overall conversion of
IQE94_RS12265	COG3093	addiction module antidote protein HigA
IQE94_RS12270	COG3549	Plasmid maintenance system killer
IQE94_RS12285	COG2217	Heavy metal translocating P-type atpase
IQE94_RS12295	COG0217	transcriptional regulatory protein
IQE94_RS12300	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IQE94_RS12305	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IQE94_RS12315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IQE94_RS12320	COG0321	lipoyl(octanoyl) transferase activity
IQE94_RS12335	COG0297	glycogen (starch) synthase activity
IQE94_RS12350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQE94_RS12355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IQE94_RS12360	COG2198	Histidine kinase
IQE94_RS12360	COG2198	Histidine kinase
IQE94_RS12360	COG0643	Histidine kinase
IQE94_RS12360	COG0784	Response regulator, receiver
IQE94_RS12360	COG0643	Histidine kinase
IQE94_RS12360	COG0784	Response regulator, receiver
IQE94_RS12380	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_RS12385	COG0494	nUDIX hydrolase
IQE94_RS12390	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IQE94_RS12395	COG0039	L-malate dehydrogenase activity
IQE94_RS12410	COG0193	aminoacyl-tRNA hydrolase activity
IQE94_RS12440	COG0024	Methionine aminopeptidase
IQE94_RS12445	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
IQE94_RS12460	COG4243	Vitamin k epoxide reductase
IQE94_RS12465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IQE94_RS12465	COG0426	domain, Protein
IQE94_RS12475	COG2251	uridine kinase activity
IQE94_RS12480	COG3063	Type IV pilus biogenesis stability protein PilW
IQE94_RS12485	COG0023	Translation Initiation Factor
IQE94_RS12525	COG2954	triphosphatase activity
IQE94_RS12535	COG0401	homolog of Blt101
IQE94_RS12540	COG2211	Major facilitator Superfamily
IQE94_RS12565	COG4451	ribulose bisphosphate carboxylase, small
IQE94_RS12575	COG1850	ribulose-bisphosphate carboxylase activity
IQE94_RS12580	COG0793	Belongs to the peptidase S41A family
IQE94_RS12595	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IQE94_RS12600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IQE94_RS12605	COG0191	fructose-bisphosphate aldolase activity
IQE94_RS12610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IQE94_RS12620	COG0542	response to heat
IQE94_RS12660	COG0124	histidyl-tRNA synthetase
IQE94_RS12670	COG0515	serine threonine protein kinase
IQE94_RS12670	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_RS12675	COG0601	transmembrane transport
IQE94_RS12685	COG1748	Saccharopine dehydrogenase
IQE94_RS12740	COG0339	signal peptide processing
IQE94_RS12745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IQE94_RS12760	COG1166	arginine decarboxylase activity
IQE94_RS12770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IQE94_RS12780	COG1049	propionate catabolic process, 2-methylcitrate cycle
IQE94_RS12820	COG5002	protein histidine kinase activity
IQE94_RS12825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IQE94_RS12830	COG2308	Evidence 4 Homologs of previously reported genes of
IQE94_RS12860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IQE94_RS12870	COG0346	lactoylglutathione lyase activity
IQE94_RS12875	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_RS12880	COG0742	ribosomal rna small subunit methyltransferase
IQE94_RS12885	COG0438	transferase activity, transferring glycosyl groups
IQE94_RS12890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IQE94_RS12900	COG1104	cysteine desulfurase activity
IQE94_RS12905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IQE94_RS12910	COG1376	ErfK ybiS ycfS ynhG family protein
IQE94_RS12930	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
IQE94_RS12940	COG3659	wide pore channel activity
IQE94_RS12945	COG0477	Major facilitator Superfamily
IQE94_RS12950	COG0515	serine threonine protein kinase
IQE94_RS12950	COG2815	serine threonine protein kinase
IQE94_RS12960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IQE94_RS12965	COG4636	protein conserved in cyanobacteria
IQE94_RS12980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IQE94_RS12985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IQE94_RS12990	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IQE94_RS12995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IQE94_RS13000	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IQE94_RS13005	COG2003	Belongs to the UPF0758 family
IQE94_RS13010	COG1054	Belongs to the UPF0176 family
IQE94_RS13025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IQE94_RS13035	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IQE94_RS13040	COG4251	negative regulation of phosphorylation
IQE94_RS13040	COG5001	Diguanylate cyclase
IQE94_RS13040	COG2203	Gaf domain
IQE94_RS13040	COG3706	GGDEF domain
IQE94_RS13050	COG0471	metal ion transport
IQE94_RS13050	COG3273	potassium ion transport
IQE94_RS13080	COG3854	ATPases associated with a variety of cellular activities
IQE94_RS13085	COG0352	thiamine-phosphate diphosphorylase activity
IQE94_RS13090	COG0434	BtpA family
IQE94_RS13115	COG0564	pseudouridine synthase activity
IQE94_RS13120	COG3706	GGDEF domain
IQE94_RS13120	COG4251	negative regulation of phosphorylation
IQE94_RS13120	COG5001	Diguanylate cyclase
IQE94_RS13120	COG2203	Gaf domain
IQE94_RS13150	COG0668	transmembrane transport
IQE94_RS13160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IQE94_RS13165	COG1733	regulation of RNA biosynthetic process
IQE94_RS13170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IQE94_RS13210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IQE94_RS13235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IQE94_RS13260	COG0436	Aminotransferase
IQE94_RS13265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IQE94_RS13280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IQE94_RS13285	COG0616	signal peptide processing
IQE94_RS13290	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IQE94_RS13300	COG0519	Catalyzes the synthesis of GMP from XMP
IQE94_RS13300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IQE94_RS13390	COG0631	protein serine/threonine phosphatase activity
IQE94_RS13395	COG2815	serine threonine protein kinase
IQE94_RS13395	COG0515	serine threonine protein kinase
IQE94_RS13400	COG1968	undecaprenyl-diphosphatase activity
IQE94_RS13420	COG5322	oxidoreductase activity
IQE94_RS13425	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IQE94_RS13435	COG0751	glycine-tRNA ligase activity
IQE94_RS13445	COG0586	Pfam SNARE associated Golgi protein
IQE94_RS13450	COG3118	belongs to the thioredoxin family
IQE94_RS13455	COG3751	2OG-Fe(II) oxygenase superfamily
IQE94_RS13460	COG0459	protein refolding
IQE94_RS13465	COG1131	(ABC) transporter
IQE94_RS13480	COG0515	serine threonine protein kinase
IQE94_RS13480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IQE94_RS13495	COG4399	Belongs to the UPF0754 family
IQE94_RS13500	COG0824	Thioesterase
IQE94_RS13505	COG4948	Mandelate Racemase Muconate Lactonizing
IQE94_RS13510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IQE94_RS13515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IQE94_RS13520	COG0511	ligase activity, forming carbon-carbon bonds
IQE94_RS13525	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_RS13545	COG0277	FAD linked oxidase domain protein
IQE94_RS13560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IQE94_RS13570	COG1494	fructose-1,6-bisphosphatase
IQE94_RS13575	COG2153	protein acetylation
IQE94_RS13610	COG2197	response regulator
IQE94_RS13625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IQE94_RS13650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IQE94_RS13680	COG4251	negative regulation of phosphorylation
IQE94_RS13680	COG2203	Gaf domain
IQE94_RS13680	COG5001	Diguanylate cyclase
IQE94_RS13680	COG3706	GGDEF domain
IQE94_RS13685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IQE94_RS13700	COG3659	wide pore channel activity
IQE94_RS13705	COG1473	amidohydrolase
IQE94_RS13710	COG0170	dolichyl monophosphate biosynthetic process
IQE94_RS13760	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IQE94_RS13765	COG4251	negative regulation of phosphorylation
IQE94_RS13790	COG1598	PFAM Uncharacterised protein family UPF0150
IQE94_RS13805	COG0825	malonyl-CoA metabolic process
IQE94_RS13820	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IQE94_RS13835	COG0148	phosphopyruvate hydratase activity
IQE94_RS13840	COG0457	Tetratricopeptide repeat
IQE94_RS13850	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
IQE94_RS13855	COG2852	Protein conserved in bacteria
IQE94_RS13860	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
IQE94_RS13870	COG1543	Belongs to the glycosyl hydrolase 57 family
IQE94_RS13880	COG3842	ATPase activity
IQE94_RS13890	COG5001	Diguanylate cyclase
IQE94_RS13890	COG1716	ATPase activity
IQE94_RS13895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IQE94_RS13920	COG0702	epimerase
IQE94_RS13935	COG0714	Associated with various cellular activities
IQE94_RS13940	COG1372	Participates in initiation and elongation during chromosome replication
IQE94_RS13940	COG0305	Participates in initiation and elongation during chromosome replication
IQE94_RS13955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IQE94_RS13960	COG0659	secondary active sulfate transmembrane transporter activity
IQE94_RS13965	COG4251	negative regulation of phosphorylation
IQE94_RS13965	COG5001	Diguanylate cyclase
IQE94_RS13965	COG2203	Gaf domain
IQE94_RS13965	COG3706	GGDEF domain
IQE94_RS13970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IQE94_RS13980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IQE94_RS13985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IQE94_RS14000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IQE94_RS14025	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IQE94_RS14040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IQE94_RS14055	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IQE94_RS14075	COG2385	sporulation resulting in formation of a cellular spore
IQE94_RS14080	COG0649	NAD binding
IQE94_RS14190	COG0418	dihydroorotase activity
IQE94_RS14235	COG1070	Carbohydrate kinase
IQE94_RS14240	COG2166	iron-sulfur cluster assembly
IQE94_RS14260	COG0515	serine threonine protein kinase
IQE94_RS14270	COG0435	Glutathione S-transferase
IQE94_RS14290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IQE94_RS14290	COG0140	phosphoribosyl-ATP diphosphatase activity
IQE94_RS14295	COG0523	cobalamin synthesis protein
IQE94_RS14305	COG0142	geranyltranstransferase activity
IQE94_RS14310	COG1187	pseudouridine synthase activity
IQE94_RS14320	COG0515	serine threonine protein kinase
IQE94_RS14325	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IQE94_RS14330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IQE94_RS14335	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IQE94_RS14355	COG1166	arginine decarboxylase activity
IQE94_RS14360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IQE94_RS14370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IQE94_RS14375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IQE94_RS14380	COG1120	ATPase activity
IQE94_RS14385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IQE94_RS14400	COG2207	Transcriptional regulator
IQE94_RS14425	COG2207	Transcriptional regulator
IQE94_RS14435	COG2226	methyltransferase
IQE94_RS14440	COG4774	siderophore transport
IQE94_RS14450	COG0848	biopolymer transport protein
IQE94_RS14455	COG0811	peptide transport
IQE94_RS14470	COG1132	(ABC) transporter
IQE94_RS14475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IQE94_RS14520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IQE94_RS14530	COG5002	protein histidine kinase activity
IQE94_RS14545	COG0363	glucosamine-6-phosphate deaminase activity
IQE94_RS14560	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IQE94_RS14595	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IQE94_RS14595	COG3264	Mechanosensitive ion channel
IQE94_RS14600	COG2052	Domain of unknown function (DUF370)
IQE94_RS14605	COG1496	oxidoreductase activity
IQE94_RS14625	COG0739	heme binding
IQE94_RS14630	COG1691	(AIR) carboxylase
IQE94_RS14645	COG2319	Wd-40 repeat
IQE94_RS14655	COG0316	Belongs to the HesB IscA family
IQE94_RS14660	COG1191	sigma factor activity
IQE94_RS14665	COG3001	Fructosamine kinase
IQE94_RS14670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IQE94_RS14675	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IQE94_RS14680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IQE94_RS14690	COG0579	oxidoreductase
IQE94_RS14705	COG2318	DinB family
IQE94_RS14710	COG4106	trans-aconitate 2-methyltransferase activity
IQE94_RS14745	COG1615	UPF0182 protein
IQE94_RS14760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IQE94_RS14765	COG1174	glycine betaine transport
IQE94_RS14770	COG0563	adenylate kinase activity
IQE94_RS14775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IQE94_RS14780	COG3118	belongs to the thioredoxin family
IQE94_RS14810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IQE94_RS14820	COG0494	nUDIX hydrolase
IQE94_RS14825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IQE94_RS14830	COG0194	GDP metabolic process
IQE94_RS14835	COG0406	alpha-ribazole phosphatase activity
IQE94_RS14845	COG0730	response to heat
IQE94_RS14850	COG1413	lyase activity
IQE94_RS14865	COG0330	HflC and HflK could
IQE94_RS14875	COG1530	ribonuclease E activity
IQE94_RS14880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IQE94_RS14885	COG0494	nUDIX hydrolase
IQE94_RS14890	COG1185	polyribonucleotide nucleotidyltransferase activity
IQE94_RS14895	COG0681	Belongs to the peptidase S26 family
IQE94_RS14915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IQE94_RS14920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IQE94_RS14935	COG0484	heat shock protein binding
IQE94_RS14965	COG1104	cysteine desulfurase activity
IQE94_RS15000	COG0582	viral genome integration into host DNA
IQE94_RS15010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IQE94_RS15010	COG2022	thiamine diphosphate biosynthetic process
IQE94_RS15015	COG5002	protein histidine kinase activity
IQE94_RS15025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IQE94_RS15045	COG0704	Plays a role in the regulation of phosphate uptake
IQE94_RS15050	COG0779	Required for maturation of 30S ribosomal subunits
IQE94_RS15055	COG0195	Participates in both transcription termination and antitermination
IQE94_RS15065	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IQE94_RS15085	COG0012	GTP binding
IQE94_RS15090	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IQE94_RS15105	COG0716	FMN binding
IQE94_RS15110	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IQE94_RS15115	COG3536	Protein conserved in bacteria
IQE94_RS15120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IQE94_RS15125	COG0429	hydrolase of the alpha beta-hydrolase fold
IQE94_RS15130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IQE94_RS15150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IQE94_RS15155	COG0643	Histidine kinase
IQE94_RS15155	COG0784	Response regulator, receiver
IQE94_RS15155	COG2198	Histidine kinase
IQE94_RS15160	COG0840	transmembrane signaling receptor activity
IQE94_RS15175	COG0784	Response regulator, receiver
IQE94_RS15180	COG0557	exoribonuclease II activity
IQE94_RS15190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IQE94_RS15205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IQE94_RS15215	COG3956	TIGRFAM MazG family protein
IQE94_RS15225	COG3447	MASE1 domain protein
IQE94_RS15225	COG5001	Diguanylate cyclase
IQE94_RS15225	COG5002	protein histidine kinase activity
IQE94_RS15235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IQE94_RS15260	COG4447	cellulose binding
IQE94_RS15265	COG1773	rubredoxin
IQE94_RS15270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IQE94_RS15295	COG0804	urea catabolic process
IQE94_RS15310	COG0398	Pfam SNARE associated Golgi protein
IQE94_RS15320	COG2226	methyltransferase
IQE94_RS15325	COG0398	Pfam SNARE associated Golgi protein
IQE94_RS15350	COG3706	GGDEF domain
IQE94_RS15355	COG5002	protein histidine kinase activity
IQE94_RS15360	COG0574	Belongs to the PEP-utilizing enzyme family
IQE94_RS15360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IQE94_RS15370	COG1716	ATPase activity
IQE94_RS15375	COG0850	regulation of cytokinetic process
IQE94_RS15380	COG2894	cell division
IQE94_RS15385	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IQE94_RS15400	COG2165	general secretion pathway protein
IQE94_RS15450	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IQE94_RS15460	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
IQE94_RS15465	COG2022	thiamine diphosphate biosynthetic process
IQE94_RS15465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IQE94_RS15475	COG2255	four-way junction helicase activity
IQE94_RS15485	COG0653	protein targeting
IQE94_RS15500	COG1842	Phage shock protein A
IQE94_RS15505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IQE94_RS15520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IQE94_RS15535	COG0581	inorganic phosphate transmembrane transporter activity
IQE94_RS15540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IQE94_RS15545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IQE94_RS15550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IQE94_RS15555	COG4232	protein-disulfide reductase activity
IQE94_RS15570	COG0475	glutathione-regulated potassium exporter activity
IQE94_RS15590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IQE94_RS15600	COG2091	lysine biosynthetic process via aminoadipic acid
IQE94_RS15605	COG0460	homoserine dehydrogenase
IQE94_RS15620	COG0318	PFAM AMP-dependent synthetase and ligase
IQE94_RS15635	COG0728	peptidoglycan biosynthetic process
IQE94_RS15645	COG5002	protein histidine kinase activity
IQE94_RS15650	COG0525	valine-tRNA ligase activity
IQE94_RS15670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IQE94_RS15685	COG0556	nucleotide-excision repair
IQE94_RS15700	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IQE94_RS15705	COG1518	maintenance of DNA repeat elements
IQE94_RS15705	COG1468	defense response to virus
IQE94_RS15730	COG1857	crispr-associated protein
IQE94_RS15740	COG1203	CRISPR-associated helicase, Cas3
IQE94_RS15755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IQE94_RS15765	COG1127	ABC transporter
IQE94_RS15775	COG0697	spore germination
IQE94_RS15780	COG0316	Belongs to the HesB IscA family
IQE94_RS15785	COG0714	Associated with various cellular activities
IQE94_RS15795	COG2205	protein histidine kinase activity
IQE94_RS15810	COG0356	it plays a direct role in the translocation of protons across the membrane
IQE94_RS15815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IQE94_RS15820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IQE94_RS15825	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IQE94_RS15835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IQE94_RS15840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IQE94_RS15855	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IQE94_RS15860	COG0009	L-threonylcarbamoyladenylate synthase
IQE94_RS15865	COG0793	Belongs to the peptidase S41A family
IQE94_RS15875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IQE94_RS15875	COG0426	domain, Protein
IQE94_RS15885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IQE94_RS15885	COG0426	domain, Protein
IQE94_RS15895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IQE94_RS15900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IQE94_RS15930	COG1598	PFAM Uncharacterised protein family UPF0150
IQE94_RS15960	COG4245	von Willebrand factor, type A
IQE94_RS15965	COG1007	ATP synthesis coupled electron transport
IQE94_RS15975	COG2099	Precorrin-6x reductase
IQE94_RS16015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IQE94_RS16020	COG0010	Belongs to the arginase family
IQE94_RS16025	COG0123	including yeast histone deacetylase and acetoin utilization protein
IQE94_RS16035	COG0589	response to stress
IQE94_RS16040	COG0011	TIGRFAM Protein of
IQE94_RS16050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IQE94_RS16055	COG0501	Belongs to the peptidase M48B family
IQE94_RS16080	COG0457	Tetratricopeptide repeat
IQE94_RS16080	COG0463	Glycosyl transferase, family 2
IQE94_RS16095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IQE94_RS16110	COG3118	belongs to the thioredoxin family
IQE94_RS16115	COG2081	HI0933 family
IQE94_RS16120	COG0469	pyruvate kinase activity
IQE94_RS16130	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IQE94_RS16155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IQE94_RS16160	COG0745	RESPONSE REGULATOR receiver
IQE94_RS16165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IQE94_RS16180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IQE94_RS16180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IQE94_RS16185	COG0848	biopolymer transport protein
IQE94_RS16190	COG0811	peptide transport
IQE94_RS16195	COG0529	Catalyzes the synthesis of activated sulfate
IQE94_RS16200	COG0737	Belongs to the 5'-nucleotidase family
IQE94_RS16210	COG2205	protein histidine kinase activity
IQE94_RS16220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IQE94_RS16225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IQE94_RS16235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IQE94_RS16260	COG0861	Integral membrane protein TerC family
IQE94_RS16265	COG0045	succinate-CoA ligase (ADP-forming) activity
IQE94_RS16270	COG3781	membrane
IQE94_RS16280	COG0644	oxidoreductase
IQE94_RS16300	COG0110	maltose O-acetyltransferase activity
IQE94_RS16330	COG0438	transferase activity, transferring glycosyl groups
IQE94_RS16345	COG0275	rRNA processing
IQE94_RS16400	COG0438	transferase activity, transferring glycosyl groups
IQE94_RS16420	COG1215	transferase activity, transferring glycosyl groups
IQE94_RS16440	COG2089	acid synthase
IQE94_RS16465	COG2089	acid synthase
IQE94_RS16505	COG1598	PFAM Uncharacterised protein family UPF0150
IQE94_RS16510	COG1388	LysM domain
IQE94_RS16510	COG1134	teichoic acid transport
IQE94_RS16565	COG1598	PFAM Uncharacterised protein family UPF0150
IQE94_RS16610	COG3206	protein involved in exopolysaccharide biosynthesis
IQE94_RS16610	COG0489	protein tyrosine kinase activity
IQE94_RS16630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IQE94_RS16635	COG4636	protein conserved in cyanobacteria
IQE94_RS16640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IQE94_RS16645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IQE94_RS16665	COG0701	Predicted permease
IQE94_RS16670	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IQE94_RS16680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IQE94_RS16700	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IQE94_RS16710	COG0523	cobalamin synthesis protein
IQE94_RS16725	COG0436	Aminotransferase
IQE94_RS16740	COG0159	tryptophan synthase activity
IQE94_RS16745	COG0592	DNA-directed DNA polymerase activity
IQE94_RS16750	COG0672	)-iron permease
IQE94_RS16755	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IQE94_RS16770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IQE94_RS16785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IQE94_RS16790	COG0573	inorganic phosphate transmembrane transporter activity
IQE94_RS16795	COG0581	inorganic phosphate transmembrane transporter activity
IQE94_RS16800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IQE94_RS16830	COG1381	Involved in DNA repair and RecF pathway recombination
IQE94_RS16865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IQE94_RS16875	COG1304	FMN binding
IQE94_RS16880	COG0745	RESPONSE REGULATOR receiver
IQE94_RS16895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IQE94_RS16905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IQE94_RS16905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IQE94_RS16910	COG3706	GGDEF domain
IQE94_RS16910	COG4251	negative regulation of phosphorylation
IQE94_RS16910	COG2203	Gaf domain
IQE94_RS16910	COG5001	Diguanylate cyclase
IQE94_RS16915	COG0784	Response regulator, receiver
IQE94_RS16925	COG0072	phenylalanine-tRNA ligase activity
IQE94_RS16925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IQE94_RS16930	COG0515	serine threonine protein kinase
IQE94_RS16930	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_RS16935	COG2197	response regulator
IQE94_RS16940	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IQE94_RS16970	COG0157	Belongs to the NadC ModD family
IQE94_RS16985	COG2082	Precorrin-8x methylmutase
IQE94_RS16990	COG0612	Peptidase, M16
IQE94_RS16995	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IQE94_RS17010	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IQE94_RS17015	COG4251	negative regulation of phosphorylation
IQE94_RS17020	COG0481	GTPase activity
IQE94_RS17025	COG0587	DNA-directed DNA polymerase activity
IQE94_RS17045	COG0515	serine threonine protein kinase
IQE94_RS17065	COG0138	bifunctional purine biosynthesis protein purh
IQE94_RS17075	COG0735	belongs to the Fur family
IQE94_RS17080	COG1136	(ABC) transporter
IQE94_RS17080	COG0577	efflux transmembrane transporter activity
IQE94_RS17085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IQE94_RS17090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IQE94_RS17105	COG0549	Belongs to the carbamate kinase family
IQE94_RS17110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IQE94_RS17135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IQE94_RS17145	COG3621	Patatin-like phospholipase
IQE94_RS17165	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_RS17170	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IQE94_RS17185	COG0137	argininosuccinate synthase activity
IQE94_RS17200	COG1064	alcohol dehydrogenase
IQE94_RS17220	COG1842	Phage shock protein A
IQE94_RS17230	COG5001	Diguanylate cyclase
IQE94_RS17230	COG3300	MHYT domain
IQE94_RS17245	COG5002	protein histidine kinase activity
IQE94_RS17255	COG0723	plastoquinol--plastocyanin reductase activity
IQE94_RS17290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IQE94_RS17300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IQE94_RS17320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IQE94_RS17325	COG0326	Molecular chaperone. Has ATPase activity
IQE94_RS17330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IQE94_RS17335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IQE94_RS17340	COG2226	methyltransferase
IQE94_RS17345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IQE94_RS17350	COG0154	amidase activity
IQE94_RS17370	COG2203	Gaf domain
IQE94_RS17370	COG3706	GGDEF domain
IQE94_RS17370	COG4251	negative regulation of phosphorylation
IQE94_RS17370	COG5001	Diguanylate cyclase
IQE94_RS17385	COG0732	type I restriction modification DNA specificity domain
IQE94_RS17435	COG0617	tRNA 3'-terminal CCA addition
IQE94_RS17445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IQE94_RS17460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IQE94_RS17470	COG1959	2 iron, 2 sulfur cluster binding
IQE94_RS17475	COG5001	Diguanylate cyclase
IQE94_RS17475	COG4251	negative regulation of phosphorylation
IQE94_RS17475	COG3706	GGDEF domain
IQE94_RS17475	COG2203	Gaf domain
IQE94_RS17480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IQE94_RS17490	COG0357	Ribosomal RNA small subunit methyltransferase G
IQE94_RS17495	COG0643	Histidine kinase
IQE94_RS17495	COG2198	Histidine kinase
IQE94_RS17505	COG0719	Fe-S assembly protein
IQE94_RS17510	COG0396	ATPase activity
IQE94_RS17515	COG0719	Fe-S assembly protein
IQE94_RS17520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IQE94_RS17525	COG0003	Pfam Anion-transporting ATPase
IQE94_RS17535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IQE94_RS17540	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IQE94_RS17545	COG0720	synthase
IQE94_RS17560	COG0328	RNA-DNA hybrid ribonuclease activity
IQE94_RS17565	COG0745	RESPONSE REGULATOR receiver
IQE94_RS17570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IQE94_RS17575	COG0513	Belongs to the DEAD box helicase family
IQE94_RS17580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IQE94_RS17585	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IQE94_RS17590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IQE94_RS17595	COG0443	Heat shock 70 kDa protein
IQE94_RS17605	COG2226	methyltransferase
IQE94_RS17610	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IQE94_RS17615	COG1012	belongs to the aldehyde dehydrogenase family
IQE94_RS17620	COG1216	Glycosyl transferase, family 2
IQE94_RS17625	COG0484	heat shock protein binding
IQE94_RS17635	COG0659	secondary active sulfate transmembrane transporter activity
IQE94_RS17645	COG1131	(ABC) transporter
IQE94_RS17650	COG0131	Imidazoleglycerol-phosphate dehydratase
IQE94_RS17660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IQE94_RS17665	COG4251	negative regulation of phosphorylation
IQE94_RS17670	COG2197	response regulator
IQE94_RS17675	COG0577	efflux transmembrane transporter activity
IQE94_RS17675	COG1136	(ABC) transporter
IQE94_RS17685	COG0515	serine threonine protein kinase
IQE94_RS17695	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_RS17710	COG0436	Aminotransferase
IQE94_RS17715	COG0586	Pfam SNARE associated Golgi protein
IQE94_RS17720	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IQE94_RS17720	COG3264	Mechanosensitive ion channel
IQE94_RS17725	COG1012	belongs to the aldehyde dehydrogenase family
IQE94_RS17750	COG1122	ATPase activity
IQE94_RS17755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IQE94_RS17780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQE94_RS17785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQE94_RS17815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IQE94_RS17845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IQE94_RS18045	COG1518	maintenance of DNA repeat elements
IQE94_RS18045	COG1468	defense response to virus
IQE94_RS18095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IQE94_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_RS18115	COG1846	Transcriptional regulator
IQE94_RS18145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IQE94_RS18155	COG4221	oxidoreductase activity
IQE94_RS18165	COG2124	cytochrome p450
IQE94_RS18180	COG0596	Alpha beta hydrolase
IQE94_RS18180	COG0508	dehydrogenase complex catalyzes the overall conversion of
IQE94_RS18200	COG1902	pentaerythritol trinitrate reductase activity
IQE94_RS18215	COG4585	Histidine kinase
IQE94_RS18220	COG2197	response regulator
IQE94_RS18225	COG0519	Catalyzes the synthesis of GMP from XMP
IQE94_RS18300	COG1404	Belongs to the peptidase S8 family
IQE94_RS18305	COG0464	growth
IQE94_RS18325	COG3961	Belongs to the TPP enzyme family
IQE94_RS18355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IQE94_RS18375	COG2211	Major facilitator Superfamily
IQE94_RS18415	COG0702	epimerase
IQE94_RS18480	COG2340	Cysteine-rich secretory protein family
IQE94_RS18635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IQE94_RS18645	COG1388	LysM domain
IQE94_RS18645	COG1134	teichoic acid transport