locus-tag	class	description
SFUM_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SFUM_RS00010	COG0776	regulation of translation
SFUM_RS00025	COG0720	synthase
SFUM_RS00035	COG0501	Belongs to the peptidase M48B family
SFUM_RS00040	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SFUM_RS00040	COG0517	IMP dehydrogenase activity
SFUM_RS00045	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SFUM_RS00050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SFUM_RS00055	COG0505	Belongs to the CarA family
SFUM_RS00060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SFUM_RS00065	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SFUM_RS00075	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SFUM_RS00085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SFUM_RS00085	COG0493	'glutamate synthase
SFUM_RS00095	COG1013	pyruvate-flavodoxin oxidoreductase activity
SFUM_RS00100	COG0674	pyruvate-flavodoxin oxidoreductase activity
SFUM_RS00100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SFUM_RS00125	COG1067	ATP-dependent peptidase activity
SFUM_RS00135	COG0011	TIGRFAM Protein of
SFUM_RS00170	COG3383	formate dehydrogenase (NAD+) activity
SFUM_RS00175	COG3383	formate dehydrogenase (NAD+) activity
SFUM_RS00190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SFUM_RS00195	COG3383	formate dehydrogenase (NAD+) activity
SFUM_RS00195	COG0243	molybdopterin cofactor binding
SFUM_RS00225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SFUM_RS00230	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SFUM_RS00240	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SFUM_RS00255	COG0549	Belongs to the carbamate kinase family
SFUM_RS00265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SFUM_RS00270	COG0741	lytic transglycosylase activity
SFUM_RS00275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SFUM_RS00285	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SFUM_RS00290	COG0436	Aminotransferase
SFUM_RS00295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SFUM_RS00300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SFUM_RS00305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SFUM_RS00320	COG0165	Argininosuccinate lyase
SFUM_RS00325	COG0137	argininosuccinate synthase activity
SFUM_RS00330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SFUM_RS00335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SFUM_RS00340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SFUM_RS00345	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SFUM_RS00350	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SFUM_RS00355	COG4974	Belongs to the 'phage' integrase family
SFUM_RS00360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SFUM_RS00370	COG0521	Mo-molybdopterin cofactor biosynthetic process
SFUM_RS00400	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
SFUM_RS00405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SFUM_RS00410	COG0148	phosphopyruvate hydratase activity
SFUM_RS00420	COG0247	lactate metabolic process
SFUM_RS00430	COG1556	Lactate utilization protein
SFUM_RS00440	COG0724	RNA recognition motif
SFUM_RS00490	COG0477	Major facilitator Superfamily
SFUM_RS00520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SFUM_RS00525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SFUM_RS00535	COG0740	serine-type endopeptidase activity
SFUM_RS00540	COG0544	peptidyl-prolyl cis-trans isomerase activity
SFUM_RS00550	COG2165	general secretion pathway protein
SFUM_RS00555	COG1242	4 iron, 4 sulfur cluster binding
SFUM_RS00560	COG0445	tRNA wobble uridine modification
SFUM_RS00570	COG2086	electron transfer activity
SFUM_RS00575	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SFUM_RS00580	COG0318	PFAM AMP-dependent synthetase and ligase
SFUM_RS00595	COG2264	protein methyltransferase activity
SFUM_RS00600	COG1028	Short-chain dehydrogenase reductase Sdr
SFUM_RS00605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SFUM_RS00610	COG1013	pyruvate-flavodoxin oxidoreductase activity
SFUM_RS00615	COG0674	pyruvate-flavodoxin oxidoreductase activity
SFUM_RS00625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SFUM_RS00630	COG1459	type II secretion system
SFUM_RS00635	COG4191	Histidine kinase
SFUM_RS00640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SFUM_RS00645	COG0459	protein refolding
SFUM_RS00650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SFUM_RS00655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SFUM_RS00680	COG1215	transferase activity, transferring glycosyl groups
SFUM_RS00700	COG0109	protoheme IX farnesyltransferase activity
SFUM_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
SFUM_RS00765	COG0242	peptide deformylase activity
SFUM_RS00770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SFUM_RS00780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SFUM_RS00780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SFUM_RS00785	COG2226	methyltransferase
SFUM_RS00800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SFUM_RS00800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SFUM_RS00805	COG1774	PSP1 C-terminal conserved region
SFUM_RS00815	COG3481	metal-dependent phosphohydrolase, HD sub domain
SFUM_RS00835	COG0237	dephospho-CoA kinase activity
SFUM_RS00850	COG1372	Participates in initiation and elongation during chromosome replication
SFUM_RS00850	COG0719	Fe-S assembly protein
SFUM_RS00855	COG0396	ATPase activity
SFUM_RS00865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SFUM_RS00870	COG0482	sulfurtransferase activity
SFUM_RS00875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SFUM_RS00880	COG0006	proline dipeptidase activity
SFUM_RS00890	COG0617	tRNA 3'-terminal CCA addition
SFUM_RS00890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SFUM_RS00890	COG0517	IMP dehydrogenase activity
SFUM_RS00900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SFUM_RS00905	COG1053	succinate dehydrogenase
SFUM_RS00965	COG0330	HflC and HflK could
SFUM_RS00970	COG0463	Glycosyl transferase, family 2
SFUM_RS00975	COG2204	response regulator
SFUM_RS00980	COG0795	lipopolysaccharide-transporting ATPase activity
SFUM_RS00990	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SFUM_RS01000	COG0525	valine-tRNA ligase activity
SFUM_RS01010	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SFUM_RS01020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SFUM_RS01025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SFUM_RS01035	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFUM_RS01045	COG0649	NAD binding
SFUM_RS01050	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SFUM_RS01055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFUM_RS01065	COG0713	ATP synthesis coupled electron transport
SFUM_RS01070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SFUM_RS01075	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFUM_RS01080	COG1007	ATP synthesis coupled electron transport
SFUM_RS01090	COG0826	peptidase U32
SFUM_RS01095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SFUM_RS01095	COG0758	DNA mediated transformation
SFUM_RS01100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SFUM_RS01105	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SFUM_RS01110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SFUM_RS01165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SFUM_RS01170	COG2816	NAD+ diphosphatase activity
SFUM_RS01175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SFUM_RS01200	COG4957	zinc ion binding
SFUM_RS01220	COG0406	alpha-ribazole phosphatase activity
SFUM_RS01230	COG2226	methyltransferase
SFUM_RS01240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SFUM_RS01245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SFUM_RS01260	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
SFUM_RS01290	COG1136	(ABC) transporter
SFUM_RS01295	COG0577	efflux transmembrane transporter activity
SFUM_RS01295	COG1136	(ABC) transporter
SFUM_RS01305	COG0577	efflux transmembrane transporter activity
SFUM_RS01320	COG1515	deoxyribonuclease V activity
SFUM_RS01330	COG0443	Heat shock 70 kDa protein
SFUM_RS01345	COG0542	response to heat
SFUM_RS01350	COG0640	Transcriptional regulator
SFUM_RS01360	COG2226	methyltransferase
SFUM_RS01370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SFUM_RS01425	COG0528	UMP kinase activity
SFUM_RS01435	COG3738	Protein conserved in bacteria
SFUM_RS01440	COG5002	protein histidine kinase activity
SFUM_RS01450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SFUM_RS01455	COG0581	inorganic phosphate transmembrane transporter activity
SFUM_RS01460	COG0573	inorganic phosphate transmembrane transporter activity
SFUM_RS01465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SFUM_RS01470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SFUM_RS01480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SFUM_RS01485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SFUM_RS01495	COG0628	permease
SFUM_RS01505	COG2205	protein histidine kinase activity
SFUM_RS01520	COG0318	PFAM AMP-dependent synthetase and ligase
SFUM_RS01525	COG0667	Aldo Keto reductase
SFUM_RS01540	COG0674	pyruvate-flavodoxin oxidoreductase activity
SFUM_RS01540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SFUM_RS01550	COG3290	protein histidine kinase activity
SFUM_RS01550	COG3829	transcription factor binding
SFUM_RS01565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SFUM_RS01570	COG0617	tRNA 3'-terminal CCA addition
SFUM_RS01575	COG0517	IMP dehydrogenase activity
SFUM_RS01580	COG0410	ABC transporter
SFUM_RS01600	COG0683	leucine binding
SFUM_RS01620	COG1100	Small GTP-binding protein
SFUM_RS01640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SFUM_RS01725	COG1294	oxidase, subunit
SFUM_RS01730	COG1271	oxidase subunit
SFUM_RS01735	COG0655	NAD(P)H dehydrogenase (quinone) activity
SFUM_RS01750	COG0443	Heat shock 70 kDa protein
SFUM_RS01765	COG1663	tetraacyldisaccharide 4'-kinase activity
SFUM_RS01785	COG4957	zinc ion binding
SFUM_RS01800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SFUM_RS01815	COG0129	dihydroxy-acid dehydratase activity
SFUM_RS01835	COG0789	Transcriptional regulator
SFUM_RS01840	COG0731	radical SAM domain protein
SFUM_RS01840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SFUM_RS01845	COG0612	Peptidase, M16
SFUM_RS01860	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SFUM_RS01865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SFUM_RS01870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SFUM_RS01875	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SFUM_RS01880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SFUM_RS01885	COG0859	PFAM glycosyl transferase family 9
SFUM_RS01890	COG0859	PFAM glycosyl transferase family 9
SFUM_RS01895	COG0859	PFAM glycosyl transferase family 9
SFUM_RS01900	COG0438	transferase activity, transferring glycosyl groups
SFUM_RS01915	COG1560	Kdo2-lipid A biosynthetic process
SFUM_RS01930	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SFUM_RS01935	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SFUM_RS01940	COG0671	phosphoesterase, PA-phosphatase related
SFUM_RS01945	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SFUM_RS01975	COG0427	acetyl-CoA hydrolase
SFUM_RS01980	COG0427	acetyl-CoA hydrolase
SFUM_RS01995	COG0277	FAD linked oxidase domain protein
SFUM_RS02000	COG0247	lactate metabolic process
SFUM_RS02025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SFUM_RS02040	COG1127	ABC transporter
SFUM_RS02045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SFUM_RS02065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SFUM_RS02100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SFUM_RS02115	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SFUM_RS02130	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SFUM_RS02140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SFUM_RS02160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SFUM_RS02170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SFUM_RS02175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SFUM_RS02180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SFUM_RS02185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SFUM_RS02190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SFUM_RS02195	COG0072	phenylalanine-tRNA ligase activity
SFUM_RS02205	COG1971	Probably functions as a manganese efflux pump
SFUM_RS02210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SFUM_RS02215	COG0047	phosphoribosylformylglycinamidine synthase activity
SFUM_RS02220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SFUM_RS02235	COG0535	radical SAM domain protein
SFUM_RS02285	COG1309	transcriptional regulator
SFUM_RS02295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SFUM_RS02300	COG0022	dehydrogenase e1 component
SFUM_RS02305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SFUM_RS02310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SFUM_RS02315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SFUM_RS02325	COG0586	Pfam SNARE associated Golgi protein
SFUM_RS02330	COG0346	lactoylglutathione lyase activity
SFUM_RS02340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFUM_RS02340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFUM_RS02345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFUM_RS02345	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFUM_RS02360	COG0039	L-malate dehydrogenase activity
SFUM_RS02365	COG0511	ligase activity, forming carbon-carbon bonds
SFUM_RS02365	COG5016	pyruvate
SFUM_RS02380	COG0330	HflC and HflK could
SFUM_RS02390	COG1573	uracil-dna glycosylase
SFUM_RS02395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SFUM_RS02405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SFUM_RS02420	COG1127	ABC transporter
SFUM_RS02425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SFUM_RS02450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SFUM_RS02480	COG0107	imidazoleglycerol-phosphate synthase activity
SFUM_RS02485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SFUM_RS02490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SFUM_RS02510	COG1950	PFAM Membrane protein of
SFUM_RS02520	COG1940	carbohydrate kinase activity
SFUM_RS02540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SFUM_RS02545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFUM_RS02550	COG1120	ATPase activity
SFUM_RS02560	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SFUM_RS02565	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SFUM_RS02565	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SFUM_RS02570	COG0105	UTP biosynthetic process
SFUM_RS02575	COG1755	Isoprenylcysteine carboxyl methyltransferase
SFUM_RS02580	COG0210	DNA helicase
SFUM_RS02590	COG4957	zinc ion binding
SFUM_RS02615	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SFUM_RS02620	COG4106	trans-aconitate 2-methyltransferase activity
SFUM_RS02660	COG2264	protein methyltransferase activity
SFUM_RS02675	COG0371	Dehydrogenase
SFUM_RS02680	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SFUM_RS02755	COG0277	FAD linked oxidase domain protein
SFUM_RS02760	COG3876	Protein conserved in bacteria
SFUM_RS02800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SFUM_RS02810	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SFUM_RS02815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SFUM_RS02820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SFUM_RS02825	COG1619	proteins homologs of microcin C7 resistance protein MccF
SFUM_RS02830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SFUM_RS02835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SFUM_RS02840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SFUM_RS02845	COG2814	Major facilitator Superfamily
SFUM_RS02895	COG0018	arginyl-trna synthetase
SFUM_RS02900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SFUM_RS02910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SFUM_RS02915	COG0343	queuine tRNA-ribosyltransferase activity
SFUM_RS02925	COG1278	Cold shock
SFUM_RS02950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SFUM_RS02950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SFUM_RS02960	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SFUM_RS02995	COG4566	intracellular signal transduction
SFUM_RS03000	COG4566	intracellular signal transduction
SFUM_RS03025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SFUM_RS03030	COG1027	Aspartate ammonia-lyase
SFUM_RS03050	COG0628	permease
SFUM_RS03060	COG0822	iron-sulfur transferase activity
SFUM_RS03075	COG0681	Belongs to the peptidase S26 family
SFUM_RS03085	COG1595	DNA-templated transcription, initiation
SFUM_RS03130	COG5557	Pfam Polysulphide reductase, NrfD
SFUM_RS03135	COG0437	4 iron, 4 sulfur cluster binding
SFUM_RS03140	COG0243	molybdopterin cofactor binding
SFUM_RS03160	COG1910	domain protein
SFUM_RS03170	COG4191	Histidine kinase
SFUM_RS03175	COG2204	response regulator
SFUM_RS03180	COG3852	Histidine kinase
SFUM_RS03190	COG2204	response regulator
SFUM_RS03205	COG0589	response to stress
SFUM_RS03215	COG0730	response to heat
SFUM_RS03235	COG3848	Pyruvate phosphate dikinase
SFUM_RS03235	COG0574	Belongs to the PEP-utilizing enzyme family
SFUM_RS03245	COG0745	RESPONSE REGULATOR receiver
SFUM_RS03250	COG2204	response regulator
SFUM_RS03260	COG0745	RESPONSE REGULATOR receiver
SFUM_RS03275	COG0730	response to heat
SFUM_RS03295	COG1914	H( )-stimulated, divalent metal cation uptake system
SFUM_RS03305	COG4191	Histidine kinase
SFUM_RS03310	COG2204	response regulator
SFUM_RS03340	COG0574	Belongs to the PEP-utilizing enzyme family
SFUM_RS03340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SFUM_RS03355	COG0745	RESPONSE REGULATOR receiver
SFUM_RS03360	COG0659	secondary active sulfate transmembrane transporter activity
SFUM_RS03365	COG2204	response regulator
SFUM_RS03380	COG0745	RESPONSE REGULATOR receiver
SFUM_RS03390	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SFUM_RS03395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SFUM_RS03430	COG0842	Transport permease protein
SFUM_RS03480	COG0439	Biotin carboxylase
SFUM_RS03495	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SFUM_RS03495	COG0617	tRNA 3'-terminal CCA addition
SFUM_RS03495	COG3620	sequence-specific DNA binding
SFUM_RS03505	COG1994	Peptidase M50
SFUM_RS03510	COG0180	Tryptophanyl-tRNA synthetase
SFUM_RS03515	COG1187	pseudouridine synthase activity
SFUM_RS03530	COG2815	serine threonine protein kinase
SFUM_RS03530	COG0515	serine threonine protein kinase
SFUM_RS03560	COG1773	rubredoxin
SFUM_RS03570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SFUM_RS03575	COG0805	protein transport
SFUM_RS03590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SFUM_RS03595	COG1333	cytochrome c biogenesis protein
SFUM_RS03600	COG0494	nUDIX hydrolase
SFUM_RS03605	COG3118	belongs to the thioredoxin family
SFUM_RS03605	COG0492	ferredoxin-NADP+ reductase activity
SFUM_RS03640	COG0704	Plays a role in the regulation of phosphate uptake
SFUM_RS03645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SFUM_RS03650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SFUM_RS03655	COG0581	inorganic phosphate transmembrane transporter activity
SFUM_RS03660	COG0573	inorganic phosphate transmembrane transporter activity
SFUM_RS03665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SFUM_RS03670	COG5002	protein histidine kinase activity
SFUM_RS03700	COG1181	Belongs to the D-alanine--D-alanine ligase family
SFUM_RS03705	COG1181	Belongs to the D-alanine--D-alanine ligase family
SFUM_RS03715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SFUM_RS03720	COG0037	tRNA processing
SFUM_RS03730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SFUM_RS03735	COG3706	GGDEF domain
SFUM_RS03745	COG0010	Belongs to the arginase family
SFUM_RS03750	COG4535	Mg2 and Co2 transporter CorC
SFUM_RS03755	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SFUM_RS03760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SFUM_RS03765	COG1968	undecaprenyl-diphosphatase activity
SFUM_RS03780	COG0004	ammonium transporteR
SFUM_RS03790	COG0557	exoribonuclease II activity
SFUM_RS03800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SFUM_RS03805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SFUM_RS03835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SFUM_RS03845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SFUM_RS03850	COG0308	aminopeptidase N
SFUM_RS03860	COG0737	Belongs to the 5'-nucleotidase family
SFUM_RS03885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SFUM_RS03890	COG0427	acetyl-CoA hydrolase
SFUM_RS03900	COG0741	lytic transglycosylase activity
SFUM_RS03915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SFUM_RS03935	COG0823	Involved in the tonB-independent uptake of proteins
SFUM_RS03940	COG2885	chlorophyll binding
SFUM_RS03950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SFUM_RS03965	COG0730	response to heat
SFUM_RS03990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SFUM_RS03995	COG1408	metallophosphoesterase
SFUM_RS04000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SFUM_RS04010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SFUM_RS04020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SFUM_RS04025	COG0529	Catalyzes the synthesis of activated sulfate
SFUM_RS04060	COG1696	Membrane protein involved in D-alanine export
SFUM_RS04115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SFUM_RS04120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SFUM_RS04150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SFUM_RS04155	COG0556	nucleotide-excision repair
SFUM_RS04170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SFUM_RS04180	COG0861	Integral membrane protein TerC family
SFUM_RS04190	COG3291	Pkd domain containing protein
SFUM_RS04205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SFUM_RS04210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SFUM_RS04215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SFUM_RS04220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SFUM_RS04225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SFUM_RS04230	COG0765	amino acid transport
SFUM_RS04250	COG2048	Heterodisulfide reductase, subunit B
SFUM_RS04260	COG2204	response regulator
SFUM_RS04295	COG2204	response regulator
SFUM_RS04330	COG1012	belongs to the aldehyde dehydrogenase family
SFUM_RS04340	COG0559	Belongs to the binding-protein-dependent transport system permease family
SFUM_RS04350	COG0411	ABC transporter
SFUM_RS04370	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SFUM_RS04400	COG4624	Iron only hydrogenase large subunit, C-terminal domain
SFUM_RS04405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SFUM_RS04405	COG4624	Iron only hydrogenase large subunit, C-terminal domain
SFUM_RS04430	COG0328	RNA-DNA hybrid ribonuclease activity
SFUM_RS04435	COG2204	response regulator
SFUM_RS04440	COG5002	protein histidine kinase activity
SFUM_RS04445	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SFUM_RS04485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SFUM_RS04515	COG0318	PFAM AMP-dependent synthetase and ligase
SFUM_RS04525	COG3854	ATPases associated with a variety of cellular activities
SFUM_RS04545	COG0571	ribonuclease III activity
SFUM_RS04550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SFUM_RS04585	COG3409	Peptidoglycan-binding domain 1 protein
SFUM_RS04585	COG3267	Type II secretory pathway component ExeA
SFUM_RS04645	COG0583	DNA-binding transcription factor activity
SFUM_RS04670	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SFUM_RS04705	COG1032	radical SAM domain protein
SFUM_RS04715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SFUM_RS04720	COG0670	Belongs to the BI1 family
SFUM_RS04730	COG4195	phage-related replication protein
SFUM_RS04745	COG1073	alpha beta
SFUM_RS04805	COG0697	spore germination
SFUM_RS04810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SFUM_RS04820	COG0587	DNA-directed DNA polymerase activity
SFUM_RS04845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SFUM_RS04850	COG0698	ribose 5-phosphate isomerase
SFUM_RS04855	COG0517	IMP dehydrogenase activity
SFUM_RS04870	COG0179	Fumarylacetoacetate (FAA) hydrolase
SFUM_RS04895	COG4566	intracellular signal transduction
SFUM_RS04900	COG4566	intracellular signal transduction
SFUM_RS04925	COG2204	response regulator
SFUM_RS04975	COG1181	Belongs to the D-alanine--D-alanine ligase family
SFUM_RS04980	COG2244	polysaccharide biosynthetic process
SFUM_RS05000	COG1216	Glycosyl transferase, family 2
SFUM_RS05025	COG1215	transferase activity, transferring glycosyl groups
SFUM_RS05035	COG0438	transferase activity, transferring glycosyl groups
SFUM_RS05050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SFUM_RS05085	COG1596	polysaccharide export
SFUM_RS05120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SFUM_RS05135	COG2210	Belongs to the sulfur carrier protein TusA family
SFUM_RS05170	COG2255	four-way junction helicase activity
SFUM_RS05175	COG0632	four-way junction helicase activity
SFUM_RS05180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SFUM_RS05185	COG0217	transcriptional regulatory protein
SFUM_RS05190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SFUM_RS05195	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SFUM_RS05205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SFUM_RS05215	COG0243	molybdopterin cofactor binding
SFUM_RS05220	COG0577	efflux transmembrane transporter activity
SFUM_RS05220	COG1136	(ABC) transporter
SFUM_RS05225	COG1136	(ABC) transporter
SFUM_RS05225	COG0577	efflux transmembrane transporter activity
SFUM_RS05245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SFUM_RS05255	COG1433	Dinitrogenase iron-molybdenum cofactor
SFUM_RS05255	COG0535	radical SAM domain protein
SFUM_RS05295	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SFUM_RS05325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SFUM_RS05330	COG1945	arginine decarboxylase activity
SFUM_RS05355	COG3267	Type II secretory pathway component ExeA
SFUM_RS05355	COG3409	Peptidoglycan-binding domain 1 protein
SFUM_RS05370	COG0728	peptidoglycan biosynthetic process
SFUM_RS05375	COG1420	regulation of RNA biosynthetic process
SFUM_RS05380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SFUM_RS05385	COG0443	Heat shock 70 kDa protein
SFUM_RS05405	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SFUM_RS05410	COG1573	uracil-dna glycosylase
SFUM_RS05435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SFUM_RS05450	COG2046	Belongs to the sulfate adenylyltransferase family
SFUM_RS05465	COG1233	COG1233 Phytoene dehydrogenase and related
SFUM_RS05475	COG2181	nitrate reductase activity
SFUM_RS05475	COG0247	lactate metabolic process
SFUM_RS05505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SFUM_RS05515	COG1606	tRNA processing
SFUM_RS05520	COG0482	sulfurtransferase activity
SFUM_RS05525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SFUM_RS05540	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SFUM_RS05585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SFUM_RS05610	COG0437	4 iron, 4 sulfur cluster binding
SFUM_RS05615	COG2414	aldehyde ferredoxin oxidoreductase
SFUM_RS05630	COG0577	efflux transmembrane transporter activity
SFUM_RS05630	COG1136	(ABC) transporter
SFUM_RS05635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SFUM_RS05685	COG4676	Protein conserved in bacteria
SFUM_RS05695	COG2373	Large extracellular alpha-helical protein
SFUM_RS05705	COG1671	Belongs to the UPF0178 family
SFUM_RS05725	COG4822	anaerobic cobalamin biosynthetic process
SFUM_RS05735	COG1122	ATPase activity
SFUM_RS05745	COG0726	polysaccharide deacetylase
SFUM_RS05750	COG0438	transferase activity, transferring glycosyl groups
SFUM_RS05795	COG0582	viral genome integration into host DNA
SFUM_RS05840	COG0745	RESPONSE REGULATOR receiver
SFUM_RS05840	COG2205	protein histidine kinase activity
SFUM_RS05840	COG4191	Histidine kinase
SFUM_RS05845	COG0318	PFAM AMP-dependent synthetase and ligase
SFUM_RS05905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SFUM_RS05935	COG0346	lactoylglutathione lyase activity
SFUM_RS05955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SFUM_RS05980	COG0437	4 iron, 4 sulfur cluster binding
SFUM_RS05995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SFUM_RS05995	COG0357	Ribosomal RNA small subunit methyltransferase G
SFUM_RS06000	COG0564	pseudouridine synthase activity
SFUM_RS06005	COG1396	sequence-specific DNA binding
SFUM_RS06010	COG1285	pathogenesis
SFUM_RS06065	COG3290	protein histidine kinase activity
SFUM_RS06065	COG3829	transcription factor binding
SFUM_RS06085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SFUM_RS06085	COG0674	pyruvate-flavodoxin oxidoreductase activity
SFUM_RS06090	COG1013	pyruvate-flavodoxin oxidoreductase activity
SFUM_RS06100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SFUM_RS06110	COG0436	Aminotransferase
SFUM_RS06115	COG1233	COG1233 Phytoene dehydrogenase and related
SFUM_RS06140	COG0492	ferredoxin-NADP+ reductase activity
SFUM_RS06185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SFUM_RS06250	COG0058	SHG alpha-glucan phosphorylase activity
SFUM_RS06265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SFUM_RS06270	COG0653	protein targeting
SFUM_RS06280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SFUM_RS06285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SFUM_RS06295	COG2233	PERMEase
SFUM_RS06300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SFUM_RS06310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SFUM_RS06325	COG0358	DNA primase activity
SFUM_RS06330	COG1610	YqeY-like protein
SFUM_RS06335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SFUM_RS06345	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SFUM_RS06355	COG0436	Aminotransferase
SFUM_RS06370	COG1473	amidohydrolase
SFUM_RS06375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SFUM_RS06395	COG0779	Required for maturation of 30S ribosomal subunits
SFUM_RS06400	COG0195	Participates in both transcription termination and antitermination
SFUM_RS06405	COG3266	domain, Protein
SFUM_RS06405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SFUM_RS06415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SFUM_RS06420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SFUM_RS06425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SFUM_RS06430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SFUM_RS06435	COG1185	polyribonucleotide nucleotidyltransferase activity
SFUM_RS06440	COG0612	Peptidase, M16
SFUM_RS06445	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SFUM_RS06455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SFUM_RS06460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SFUM_RS06490	COG1218	3'(2'),5'-bisphosphate nucleotidase
SFUM_RS06495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SFUM_RS06530	COG0702	epimerase
SFUM_RS06560	COG0322	excinuclease ABC activity
SFUM_RS06580	COG1960	acyl-CoA dehydrogenase activity
SFUM_RS06595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SFUM_RS06605	COG0037	tRNA processing
SFUM_RS06615	COG0442	prolyl-tRNA aminoacylation
SFUM_RS06620	COG0071	Belongs to the small heat shock protein (HSP20) family
SFUM_RS06625	COG0501	Belongs to the peptidase M48B family
SFUM_RS06630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SFUM_RS06660	COG0427	acetyl-CoA hydrolase
SFUM_RS06675	COG2894	cell division
SFUM_RS06680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SFUM_RS06720	COG1322	Protein conserved in bacteria
SFUM_RS06725	COG1832	CoA-binding protein
SFUM_RS06765	COG1355	regulation of microtubule-based process
SFUM_RS06770	COG2078	PFAM AMMECR1 domain protein
SFUM_RS06790	COG0489	protein tyrosine kinase activity
SFUM_RS06795	COG1686	Belongs to the peptidase S11 family
SFUM_RS06805	COG2234	aminopeptidase activity
SFUM_RS06815	COG1012	belongs to the aldehyde dehydrogenase family
SFUM_RS06835	COG2226	methyltransferase
SFUM_RS06845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SFUM_RS06855	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SFUM_RS06855	COG3608	succinylglutamate desuccinylase aspartoacylase
SFUM_RS06865	COG0243	molybdopterin cofactor binding
SFUM_RS06915	COG0667	Aldo Keto reductase
SFUM_RS06920	COG0348	domain, Protein
SFUM_RS06920	COG3901	Regulator of nitric oxide reductase transcription
SFUM_RS06935	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SFUM_RS06940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SFUM_RS06965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SFUM_RS06970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SFUM_RS06975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SFUM_RS07000	COG1332	CRISPR-associated RAMP protein, Csm5 family
SFUM_RS07060	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SFUM_RS07085	COG0481	GTPase activity
SFUM_RS07105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SFUM_RS07120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SFUM_RS07125	COG0416	fatty acid biosynthetic process
SFUM_RS07135	COG2086	electron transfer activity
SFUM_RS07140	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SFUM_RS07150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SFUM_RS07155	COG0698	ribose 5-phosphate isomerase
SFUM_RS07160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SFUM_RS07165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SFUM_RS07165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SFUM_RS07175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SFUM_RS07175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SFUM_RS07180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SFUM_RS07185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SFUM_RS07195	COG1191	sigma factor activity
SFUM_RS07210	COG0501	Belongs to the peptidase M48B family
SFUM_RS07220	COG1132	(ABC) transporter
SFUM_RS07225	COG1132	(ABC) transporter
SFUM_RS07235	COG0483	inositol monophosphate 1-phosphatase activity
SFUM_RS07245	COG1024	Enoyl-CoA hydratase
SFUM_RS07260	COG0446	pyridine nucleotide-disulphide oxidoreductase
SFUM_RS07270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SFUM_RS07275	COG1309	transcriptional regulator
SFUM_RS07280	COG1960	acyl-CoA dehydrogenase activity
SFUM_RS07285	COG0183	Belongs to the thiolase family
SFUM_RS07290	COG1024	Enoyl-CoA hydratase
SFUM_RS07290	COG1250	3-hydroxyacyl-CoA dehydrogenase
SFUM_RS07325	COG0747	negative chemotaxis
SFUM_RS07335	COG0601	transmembrane transport
SFUM_RS07340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SFUM_RS07350	COG1722	exodeoxyribonuclease VII activity
SFUM_RS07360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SFUM_RS07365	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SFUM_RS07370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SFUM_RS07375	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SFUM_RS07380	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SFUM_RS07390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SFUM_RS07395	COG0776	regulation of translation
SFUM_RS07405	COG1254	Belongs to the acylphosphatase family
SFUM_RS07410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SFUM_RS07445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SFUM_RS07450	COG1032	radical SAM domain protein
SFUM_RS07455	COG0456	acetyltransferase
SFUM_RS07475	COG0537	adenosine 5'-monophosphoramidase activity
SFUM_RS07500	COG1053	succinate dehydrogenase
SFUM_RS07505	COG0784	Response regulator, receiver
SFUM_RS07530	COG0513	Belongs to the DEAD box helicase family
SFUM_RS07580	COG3064	Membrane
SFUM_RS07615	COG0191	fructose-bisphosphate aldolase activity
SFUM_RS07620	COG0058	SHG alpha-glucan phosphorylase activity
SFUM_RS07630	COG0857	belongs to the CobB CobQ family
SFUM_RS07630	COG0280	phosphate acetyltransferase
SFUM_RS07635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SFUM_RS07650	COG2985	domain, Protein
SFUM_RS07650	COG0569	domain protein
SFUM_RS07660	COG2414	aldehyde ferredoxin oxidoreductase
SFUM_RS07680	COG0484	heat shock protein binding
SFUM_RS07700	COG3852	Histidine kinase
SFUM_RS07705	COG2204	response regulator
SFUM_RS07730	COG4964	Belongs to the GSP D family
SFUM_RS07800	COG3842	ATPase activity
SFUM_RS07865	COG2203	Gaf domain
SFUM_RS07865	COG3706	GGDEF domain
SFUM_RS07865	COG5001	Diguanylate cyclase
SFUM_RS07865	COG4251	negative regulation of phosphorylation
SFUM_RS07885	COG0730	response to heat
SFUM_RS07890	COG2186	Transcriptional regulator
SFUM_RS07915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SFUM_RS07925	COG3263	regulation of cellular component size
SFUM_RS07935	COG0679	Auxin Efflux Carrier
SFUM_RS07945	COG0372	Belongs to the citrate synthase family
SFUM_RS07990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SFUM_RS07995	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SFUM_RS08005	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SFUM_RS08010	COG0081	regulation of translation
SFUM_RS08015	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SFUM_RS08020	COG0222	ribosome binding
SFUM_RS08025	COG0085	RNA polymerase activity
SFUM_RS08030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SFUM_RS08035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SFUM_RS08040	COG0049	tRNA binding
SFUM_RS08045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SFUM_RS08050	COG0051	transcription antitermination factor activity, RNA binding
SFUM_RS08055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SFUM_RS08060	COG0088	Forms part of the polypeptide exit tunnel
SFUM_RS08065	COG0089	rRNA binding
SFUM_RS08070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SFUM_RS08075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SFUM_RS08080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SFUM_RS08085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SFUM_RS08090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SFUM_RS08095	COG0255	Belongs to the universal ribosomal protein uL29 family
SFUM_RS08100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SFUM_RS08105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SFUM_RS08110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SFUM_RS08115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SFUM_RS08120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SFUM_RS08125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SFUM_RS08130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SFUM_RS08135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SFUM_RS08140	COG1841	ribosomal large subunit assembly
SFUM_RS08145	COG0200	Binds to the 23S rRNA
SFUM_RS08155	COG0563	adenylate kinase activity
SFUM_RS08165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SFUM_RS08170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SFUM_RS08175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SFUM_RS08180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SFUM_RS08185	COG0202	RNA polymerase activity
SFUM_RS08190	COG0203	ribosomal protein L17
SFUM_RS08205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SFUM_RS08210	COG0142	geranyltranstransferase activity
SFUM_RS08220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SFUM_RS08225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SFUM_RS08235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SFUM_RS08245	COG0629	single-stranded DNA binding
SFUM_RS08255	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SFUM_RS08260	COG1674	ftsk spoiiie
SFUM_RS08270	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SFUM_RS08275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SFUM_RS08280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SFUM_RS08285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SFUM_RS08290	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SFUM_RS08295	COG0356	it plays a direct role in the translocation of protons across the membrane
SFUM_RS08310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SFUM_RS08320	COG1032	radical SAM domain protein
SFUM_RS08340	COG0037	tRNA processing
SFUM_RS08420	COG0668	transmembrane transport
SFUM_RS08460	COG0215	cysteine-tRNA ligase activity
SFUM_RS08470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SFUM_RS08475	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SFUM_RS08485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SFUM_RS08505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SFUM_RS08520	COG2201	protein-glutamate methylesterase activity
SFUM_RS08525	COG0835	chemotaxis
SFUM_RS08530	COG0840	transmembrane signaling receptor activity
SFUM_RS08535	COG2201	protein-glutamate methylesterase activity
SFUM_RS08560	COG1100	Small GTP-binding protein
SFUM_RS08570	COG1234	tRNA 3'-trailer cleavage
SFUM_RS08575	COG0598	Magnesium transport protein CorA
SFUM_RS08600	COG0745	RESPONSE REGULATOR receiver
SFUM_RS08605	COG2197	response regulator
SFUM_RS08620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SFUM_RS08625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SFUM_RS08630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SFUM_RS08660	COG0321	lipoyl(octanoyl) transferase activity
SFUM_RS08665	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SFUM_RS08675	COG0411	ABC transporter
SFUM_RS08700	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SFUM_RS08710	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SFUM_RS08710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SFUM_RS08725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SFUM_RS08740	COG1752	Esterase of the alpha-beta hydrolase superfamily
SFUM_RS08745	COG0351	phosphomethylpyrimidine kinase
SFUM_RS08750	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SFUM_RS08775	COG1111	helicase
SFUM_RS08775	COG1205	dead DEAH box helicase
SFUM_RS08785	COG0303	'Molybdopterin
SFUM_RS08795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SFUM_RS08800	COG0045	succinate-CoA ligase (ADP-forming) activity
SFUM_RS08810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SFUM_RS08815	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SFUM_RS08820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SFUM_RS08825	COG3118	belongs to the thioredoxin family
SFUM_RS08845	COG0254	rRNA binding
SFUM_RS08850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SFUM_RS08855	COG2890	protein-(glutamine-N5) methyltransferase activity
SFUM_RS08860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SFUM_RS08865	COG2333	competence protein COMEC
SFUM_RS08865	COG0658	competence protein
SFUM_RS08875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SFUM_RS08895	COG0753	catalase activity
SFUM_RS08905	COG0493	'glutamate synthase
SFUM_RS08930	COG0284	orotidine-5'-phosphate decarboxylase activity
SFUM_RS08945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SFUM_RS08950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SFUM_RS08970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SFUM_RS08975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SFUM_RS08980	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SFUM_RS08985	COG1492	cobalamin metabolic process
SFUM_RS08990	COG1797	cobyrinic acid a,c-diamide synthase activity
SFUM_RS08995	COG1074	ATP-dependent DNA helicase activity
SFUM_RS09000	COG0071	Belongs to the small heat shock protein (HSP20) family
SFUM_RS09035	COG1268	BioY protein
SFUM_RS09040	COG1122	ATPase activity
SFUM_RS09045	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SFUM_RS09075	COG0484	heat shock protein binding
SFUM_RS09090	COG1758	RNA polymerase activity
SFUM_RS09110	COG0667	Aldo Keto reductase
SFUM_RS09135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SFUM_RS09150	COG0159	tryptophan synthase activity
SFUM_RS09155	COG0133	tryptophan synthase activity
SFUM_RS09160	COG0135	phosphoribosylanthranilate isomerase activity
SFUM_RS09165	COG0134	indole-3-glycerol-phosphate synthase activity
SFUM_RS09170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SFUM_RS09175	COG0512	Glutamine amidotransferase of anthranilate synthase
SFUM_RS09180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SFUM_RS09185	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SFUM_RS09190	COG0052	Belongs to the universal ribosomal protein uS2 family
SFUM_RS09195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SFUM_RS09200	COG0528	UMP kinase activity
SFUM_RS09205	COG0233	cytoplasmic translational termination
SFUM_RS09210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SFUM_RS09220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SFUM_RS09225	COG0750	zinc metalloprotease
SFUM_RS09230	COG1214	PFAM Peptidase M22, glycoprotease
SFUM_RS09280	COG3383	formate dehydrogenase (NAD+) activity
SFUM_RS09285	COG3383	formate dehydrogenase (NAD+) activity
SFUM_RS09300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SFUM_RS09310	COG0445	tRNA wobble uridine modification
SFUM_RS09315	COG2181	nitrate reductase activity
SFUM_RS09315	COG0247	lactate metabolic process
SFUM_RS09340	COG3158	transport of potassium into the cell
SFUM_RS09345	COG1160	GTP binding
SFUM_RS09360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SFUM_RS09375	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SFUM_RS09385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SFUM_RS09390	COG3360	Dodecin
SFUM_RS09405	COG2022	thiamine diphosphate biosynthetic process
SFUM_RS09420	COG0352	thiamine-phosphate diphosphorylase activity
SFUM_RS09425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SFUM_RS09430	COG0842	Transport permease protein
SFUM_RS09455	COG1530	ribonuclease E activity
SFUM_RS09480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SFUM_RS09495	COG2183	response to ionizing radiation
SFUM_RS09515	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SFUM_RS09520	COG1027	Aspartate ammonia-lyase
SFUM_RS09525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SFUM_RS09530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SFUM_RS09565	COG3960	tartronate-semialdehyde synthase activity
SFUM_RS09610	COG1132	(ABC) transporter
SFUM_RS09615	COG0784	Response regulator, receiver
SFUM_RS09620	COG4251	negative regulation of phosphorylation
SFUM_RS09625	COG1611	Belongs to the LOG family
SFUM_RS09635	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SFUM_RS09695	COG4373	Mu-like prophage FluMu protein gp28
SFUM_RS09700	COG4383	Mu-like prophage protein gp29
SFUM_RS09725	COG4397	Mu-like prophage major head subunit gpT
SFUM_RS09735	COG4387	Mu-like prophage protein GP36
SFUM_RS09835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SFUM_RS09845	COG0583	DNA-binding transcription factor activity
SFUM_RS09855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SFUM_RS09885	COG0517	IMP dehydrogenase activity
SFUM_RS09895	COG1077	Cell shape determining protein MreB Mrl
SFUM_RS09910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SFUM_RS09915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SFUM_RS09930	COG4221	oxidoreductase activity
SFUM_RS09945	COG0564	pseudouridine synthase activity
SFUM_RS09975	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SFUM_RS09985	COG5000	phosphorelay sensor kinase activity
SFUM_RS09990	COG2204	response regulator
SFUM_RS10000	COG1007	ATP synthesis coupled electron transport
SFUM_RS10005	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFUM_RS10010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SFUM_RS10015	COG0713	ATP synthesis coupled electron transport
SFUM_RS10025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFUM_RS10035	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SFUM_RS10040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFUM_RS10040	COG0649	NAD binding
SFUM_RS10040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFUM_RS10045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFUM_RS10075	COG3209	COG3209 Rhs family protein
SFUM_RS10095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SFUM_RS10100	COG0166	Belongs to the GPI family
SFUM_RS10120	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SFUM_RS10130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SFUM_RS10145	COG1433	Dinitrogenase iron-molybdenum cofactor
SFUM_RS10145	COG0535	radical SAM domain protein
SFUM_RS10150	COG0616	signal peptide processing
SFUM_RS10180	COG0432	Pfam Uncharacterised protein family UPF0047
SFUM_RS10190	COG0247	lactate metabolic process
SFUM_RS10235	COG0446	pyridine nucleotide-disulphide oxidoreductase
SFUM_RS10245	COG4464	protein tyrosine phosphatase activity
SFUM_RS10255	COG1082	Xylose isomerase domain protein TIM barrel
SFUM_RS10265	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SFUM_RS10270	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SFUM_RS10275	COG0602	queuosine metabolic process
SFUM_RS10300	COG1657	PFAM Prenyltransferase squalene oxidase
SFUM_RS10325	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SFUM_RS10340	COG0204	Acyl-transferase
SFUM_RS10345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SFUM_RS10350	COG1053	succinate dehydrogenase
SFUM_RS10380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SFUM_RS10385	COG2205	protein histidine kinase activity
SFUM_RS10415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SFUM_RS10430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SFUM_RS10515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SFUM_RS10530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SFUM_RS10565	COG2321	neutral zinc metallopeptidase
SFUM_RS10615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SFUM_RS10620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SFUM_RS10645	COG3177	Filamentation induced by cAMP protein fic
SFUM_RS10660	COG0149	triose-phosphate isomerase activity
SFUM_RS10665	COG0126	phosphoglycerate kinase activity
SFUM_RS10675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SFUM_RS10680	COG0574	Belongs to the PEP-utilizing enzyme family
SFUM_RS10680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SFUM_RS10695	COG1660	Displays ATPase and GTPase activities
SFUM_RS10700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SFUM_RS10730	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SFUM_RS10735	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SFUM_RS10740	COG0504	CTP synthase activity
SFUM_RS10750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SFUM_RS10770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SFUM_RS10775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SFUM_RS10785	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SFUM_RS10790	COG0495	leucyl-tRNA aminoacylation
SFUM_RS10805	COG0268	Binds directly to 16S ribosomal RNA
SFUM_RS10810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SFUM_RS10815	COG0540	Belongs to the ATCase OTCase family
SFUM_RS10820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SFUM_RS10850	COG1917	Cupin 2, conserved barrel domain protein
SFUM_RS10850	COG4977	sequence-specific DNA binding
SFUM_RS10875	COG0114	fumarate hydratase activity
SFUM_RS10880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SFUM_RS10890	COG0372	Belongs to the citrate synthase family
SFUM_RS10895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SFUM_RS10900	COG0776	regulation of translation
SFUM_RS10925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SFUM_RS10930	COG0297	glycogen (starch) synthase activity
SFUM_RS10940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SFUM_RS10945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SFUM_RS10950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SFUM_RS10955	COG0539	negative regulation of cytoplasmic translation
SFUM_RS10955	COG2183	response to ionizing radiation
SFUM_RS10960	COG0616	signal peptide processing
SFUM_RS10965	COG0009	L-threonylcarbamoyladenylate synthase
SFUM_RS10970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SFUM_RS10970	COG0248	Ppx GppA phosphatase
SFUM_RS10975	COG0517	IMP dehydrogenase activity
SFUM_RS10975	COG0516	GMP reductase activity
SFUM_RS10985	COG0519	Catalyzes the synthesis of GMP from XMP
SFUM_RS11030	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SFUM_RS11040	COG1120	ATPase activity
SFUM_RS11045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFUM_RS11060	COG1615	UPF0182 protein
SFUM_RS11105	COG0247	lactate metabolic process
SFUM_RS11125	COG0493	'glutamate synthase
SFUM_RS11125	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SFUM_RS11130	COG0543	2 iron, 2 sulfur cluster binding
SFUM_RS11135	COG3383	formate dehydrogenase (NAD+) activity
SFUM_RS11155	COG3119	arylsulfatase activity
SFUM_RS11160	COG0641	radical SAM
SFUM_RS11175	COG3956	TIGRFAM MazG family protein
SFUM_RS11190	COG1702	phosphate starvation-inducible protein PhoH
SFUM_RS11195	COG1480	7TM receptor with intracellular HD hydrolase
SFUM_RS11200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SFUM_RS11205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SFUM_RS11210	COG0736	holo-[acyl-carrier-protein] synthase activity
SFUM_RS11215	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SFUM_RS11215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SFUM_RS11220	COG0802	atpase or kinase
SFUM_RS11230	COG1032	radical SAM domain protein
SFUM_RS11240	COG0527	aspartate kinase activity
SFUM_RS11245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SFUM_RS11285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SFUM_RS11320	COG0438	transferase activity, transferring glycosyl groups
SFUM_RS11330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SFUM_RS11350	COG0791	NLP P60 protein
SFUM_RS11365	COG0535	radical SAM domain protein
SFUM_RS11395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SFUM_RS11395	COG0617	tRNA 3'-terminal CCA addition
SFUM_RS11395	COG0517	IMP dehydrogenase activity
SFUM_RS11405	COG2770	Histidine kinase
SFUM_RS11405	COG2208	phosphoserine phosphatase activity
SFUM_RS11410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SFUM_RS11435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SFUM_RS11450	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SFUM_RS11455	COG3290	protein histidine kinase activity
SFUM_RS11455	COG3829	transcription factor binding
SFUM_RS11470	COG1116	anion transmembrane transporter activity
SFUM_RS11475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SFUM_RS11500	COG3259	Nickel-dependent hydrogenase
SFUM_RS11505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFUM_RS11525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SFUM_RS11525	COG4499	WXG100 protein secretion system (Wss), protein YukC
SFUM_RS11530	COG2373	Large extracellular alpha-helical protein
SFUM_RS11560	COG1136	(ABC) transporter
SFUM_RS11560	COG0577	efflux transmembrane transporter activity
SFUM_RS11565	COG1136	(ABC) transporter
SFUM_RS11565	COG0577	efflux transmembrane transporter activity
SFUM_RS11570	COG0156	8-amino-7-oxononanoate synthase activity
SFUM_RS11580	COG0398	Pfam SNARE associated Golgi protein
SFUM_RS11610	COG0463	Glycosyl transferase, family 2
SFUM_RS11640	COG2132	Multicopper oxidase
SFUM_RS11655	COG1064	alcohol dehydrogenase
SFUM_RS11665	COG0602	queuosine metabolic process
SFUM_RS11705	COG0438	transferase activity, transferring glycosyl groups
SFUM_RS11745	COG0589	response to stress
SFUM_RS11750	COG4651	solute:proton antiporter activity
SFUM_RS11750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SFUM_RS11760	COG0306	phosphate transporter
SFUM_RS11780	COG1404	Belongs to the peptidase S8 family
SFUM_RS11780	COG4412	M6 family metalloprotease domain protein
SFUM_RS11820	COG2414	aldehyde ferredoxin oxidoreductase
SFUM_RS11825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SFUM_RS11845	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SFUM_RS11850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SFUM_RS11855	COG2204	response regulator
SFUM_RS11865	COG5002	protein histidine kinase activity
SFUM_RS11900	COG1942	4-Oxalocrotonate Tautomerase
SFUM_RS11915	COG2198	Histidine kinase
SFUM_RS11915	COG0784	Response regulator, receiver
SFUM_RS11915	COG2205	protein histidine kinase activity
SFUM_RS11930	COG2202	Pas domain
SFUM_RS11930	COG2200	EAL domain
SFUM_RS11930	COG2199	diguanylate cyclase activity
SFUM_RS11995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SFUM_RS12000	COG2249	NAD(P)H dehydrogenase (quinone) activity
SFUM_RS12015	COG3064	Membrane
SFUM_RS12020	COG1032	radical SAM domain protein
SFUM_RS12025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SFUM_RS12030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SFUM_RS12045	COG2819	hydrolase of the alpha beta superfamily
SFUM_RS12060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SFUM_RS12070	COG0534	Mate efflux family protein
SFUM_RS12085	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SFUM_RS12085	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SFUM_RS12095	COG0529	Catalyzes the synthesis of activated sulfate
SFUM_RS12110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SFUM_RS12135	COG0459	protein refolding
SFUM_RS12150	COG0438	transferase activity, transferring glycosyl groups
SFUM_RS12170	COG0038	chloride channel
SFUM_RS12230	COG0484	heat shock protein binding
SFUM_RS12240	COG0071	Belongs to the small heat shock protein (HSP20) family
SFUM_RS12245	COG4974	Belongs to the 'phage' integrase family
SFUM_RS12285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SFUM_RS12290	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SFUM_RS12295	COG1228	amidohydrolase
SFUM_RS12300	COG2986	histidine ammonia-lyase
SFUM_RS12315	COG3103	Sh3 type 3 domain protein
SFUM_RS12315	COG0860	N-Acetylmuramoyl-L-alanine amidase
SFUM_RS12315	COG4991	sh3 domain protein
SFUM_RS12320	COG0501	Belongs to the peptidase M48B family
SFUM_RS12350	COG0477	Major facilitator Superfamily
SFUM_RS12365	COG1131	(ABC) transporter
SFUM_RS12370	COG0842	Transport permease protein
SFUM_RS12375	COG0842	Transport permease protein
SFUM_RS12390	COG1914	H( )-stimulated, divalent metal cation uptake system
SFUM_RS12395	COG2239	Acts as a magnesium transporter
SFUM_RS12405	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SFUM_RS12435	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SFUM_RS12455	COG1090	epimerase
SFUM_RS12460	COG0492	ferredoxin-NADP+ reductase activity
SFUM_RS12475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SFUM_RS12490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SFUM_RS12500	COG3008	intermembrane lipid transfer
SFUM_RS12500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SFUM_RS12570	COG0535	radical SAM domain protein
SFUM_RS12585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SFUM_RS12585	COG0475	glutathione-regulated potassium exporter activity
SFUM_RS12610	COG1027	Aspartate ammonia-lyase
SFUM_RS12615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SFUM_RS12630	COG2204	response regulator
SFUM_RS12645	COG0751	glycine-tRNA ligase activity
SFUM_RS12650	COG0752	glycyl-tRNA synthetase alpha subunit
SFUM_RS12665	COG1127	ABC transporter
SFUM_RS12670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SFUM_RS12685	COG2208	phosphoserine phosphatase activity
SFUM_RS12695	COG0641	radical SAM
SFUM_RS12705	COG0552	protein localization to endoplasmic reticulum
SFUM_RS12710	COG0191	fructose-bisphosphate aldolase activity
SFUM_RS12720	COG1063	alcohol dehydrogenase
SFUM_RS12725	COG1830	Aldolase
SFUM_RS12750	COG1592	Rubrerythrin
SFUM_RS12760	COG1490	D-aminoacyl-tRNA deacylase activity
SFUM_RS12775	COG1691	(AIR) carboxylase
SFUM_RS12780	COG1519	Transferase
SFUM_RS12785	COG0017	Asparaginyl-tRNA synthetase
SFUM_RS12810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SFUM_RS12880	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SFUM_RS12880	COG1918	ferrous iron import across plasma membrane
SFUM_RS12885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SFUM_RS12890	COG4191	Histidine kinase
SFUM_RS12905	COG0577	efflux transmembrane transporter activity
SFUM_RS12960	COG1136	(ABC) transporter
SFUM_RS12970	COG2080	2 iron, 2 sulfur cluster binding
SFUM_RS12975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SFUM_RS12985	COG0693	protein deglycase activity
SFUM_RS13005	COG1129	ABC transporter
SFUM_RS13010	COG4603	Belongs to the binding-protein-dependent transport system permease family
SFUM_RS13015	COG1079	Belongs to the binding-protein-dependent transport system permease family
SFUM_RS13030	COG1136	(ABC) transporter
SFUM_RS13045	COG1408	metallophosphoesterase
SFUM_RS13055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SFUM_RS13060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SFUM_RS13065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SFUM_RS13075	COG1546	Belongs to the CinA family
SFUM_RS13075	COG1058	Belongs to the CinA family
SFUM_RS13080	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SFUM_RS13105	COG1715	Restriction endonuclease
SFUM_RS13145	COG1716	ATPase activity
SFUM_RS13150	COG0430	RNA-3'-phosphate cyclase activity
SFUM_RS13175	COG1331	Highly conserved protein containing a thioredoxin domain
SFUM_RS13190	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SFUM_RS13255	COG5002	protein histidine kinase activity
SFUM_RS13265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SFUM_RS13265	COG0574	Belongs to the PEP-utilizing enzyme family
SFUM_RS13310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SFUM_RS13315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SFUM_RS13320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SFUM_RS13330	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SFUM_RS13370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SFUM_RS13375	COG1418	mRNA catabolic process
SFUM_RS13385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SFUM_RS13390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SFUM_RS13395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SFUM_RS13400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SFUM_RS13405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SFUM_RS13410	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SFUM_RS13415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SFUM_RS13425	COG0772	Belongs to the SEDS family
SFUM_RS13445	COG1077	Cell shape determining protein MreB Mrl
SFUM_RS13455	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SFUM_RS13460	COG0594	ribonuclease P activity
SFUM_RS13465	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SFUM_RS13470	COG0706	membrane insertase activity
SFUM_RS13475	COG1847	R3H domain protein
SFUM_RS13480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SFUM_RS13500	COG1535	isochorismatase
SFUM_RS13500	COG3433	isochorismatase activity
SFUM_RS13510	COG1192	Involved in chromosome partitioning
SFUM_RS13515	COG1475	DNA binding
SFUM_RS13530	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SFUM_RS13545	COG0315	cyclic pyranopterin monophosphate synthase activity
SFUM_RS13570	COG1132	(ABC) transporter
SFUM_RS13575	COG2205	protein histidine kinase activity
SFUM_RS13590	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SFUM_RS13595	COG5002	protein histidine kinase activity
SFUM_RS13610	COG0275	rRNA processing
SFUM_RS13640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SFUM_RS13645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SFUM_RS13650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SFUM_RS13705	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SFUM_RS13710	COG0513	Belongs to the DEAD box helicase family
SFUM_RS13715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SFUM_RS13720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SFUM_RS13725	COG0508	dehydrogenase complex catalyzes the overall conversion of
SFUM_RS13740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SFUM_RS13770	COG4452	Inner membrane protein CreD
SFUM_RS13780	COG0745	RESPONSE REGULATOR receiver
SFUM_RS13785	COG2205	protein histidine kinase activity
SFUM_RS13835	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SFUM_RS13865	COG4191	Histidine kinase
SFUM_RS13870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SFUM_RS13880	COG1199	ATP-dependent helicase activity
SFUM_RS13905	COG1045	serine acetyltransferase
SFUM_RS13925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SFUM_RS13930	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SFUM_RS13935	COG0592	DNA-directed DNA polymerase activity
SFUM_RS13940	COG0187	DNA topoisomerase II activity
SFUM_RS13950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SFUM_RS13960	COG1477	protein flavinylation
SFUM_RS13965	COG2878	Part of a membrane complex involved in electron transport
SFUM_RS13965	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
SFUM_RS13975	COG4660	Part of a membrane complex involved in electron transport
SFUM_RS13980	COG4659	FMN binding
SFUM_RS13985	COG4658	electron transport chain
SFUM_RS13990	COG4656	Part of a membrane complex involved in electron transport
SFUM_RS14015	COG3383	formate dehydrogenase (NAD+) activity
SFUM_RS14020	COG3383	formate dehydrogenase (NAD+) activity
SFUM_RS14025	COG2116	formate transmembrane transporter activity
SFUM_RS14045	COG1047	Peptidyl-prolyl cis-trans
SFUM_RS14070	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
SFUM_RS14075	COG3259	Nickel-dependent hydrogenase
SFUM_RS14100	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SFUM_RS14105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SFUM_RS14110	COG0710	3-dehydroquinate dehydratase activity
SFUM_RS14115	COG0077	Prephenate dehydratase
SFUM_RS14115	COG1605	Chorismate mutase
SFUM_RS14120	COG1465	3-dehydroquinate synthase
SFUM_RS14150	COG0784	Response regulator, receiver
SFUM_RS14165	COG1121	(ABC) transporter
SFUM_RS14170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SFUM_RS14175	COG1657	PFAM Prenyltransferase squalene oxidase
SFUM_RS14180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SFUM_RS14185	COG1120	ATPase activity
SFUM_RS14190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFUM_RS14210	COG4771	TonB-dependent receptor
SFUM_RS14220	COG4822	anaerobic cobalamin biosynthetic process
SFUM_RS14240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SFUM_RS14265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SFUM_RS14285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SFUM_RS14290	COG0009	L-threonylcarbamoyladenylate synthase
SFUM_RS14295	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SFUM_RS14300	COG0151	Belongs to the GarS family
SFUM_RS14305	COG0138	bifunctional purine biosynthesis protein purh
SFUM_RS14325	COG3852	Histidine kinase
SFUM_RS14330	COG2204	response regulator
SFUM_RS14340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SFUM_RS14350	COG0598	Magnesium transport protein CorA
SFUM_RS14435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SFUM_RS14470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SFUM_RS14475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SFUM_RS14480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SFUM_RS14485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SFUM_RS14495	COG0674	pyruvate-flavodoxin oxidoreductase activity
SFUM_RS14500	COG1013	pyruvate-flavodoxin oxidoreductase activity
SFUM_RS14535	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SFUM_RS14555	COG2204	response regulator
SFUM_RS14560	COG3852	Histidine kinase
SFUM_RS14565	COG1104	cysteine desulfurase activity
SFUM_RS14575	COG1136	(ABC) transporter
SFUM_RS14575	COG0577	efflux transmembrane transporter activity
SFUM_RS14605	COG1136	(ABC) transporter
SFUM_RS14605	COG0577	efflux transmembrane transporter activity
SFUM_RS14615	COG1342	Belongs to the UPF0251 family
SFUM_RS14630	COG0419	ATPase involved in DNA repair
SFUM_RS14655	COG1857	crispr-associated protein
SFUM_RS14670	COG1518	maintenance of DNA repeat elements
SFUM_RS14675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SFUM_RS14690	COG2226	methyltransferase
SFUM_RS14760	COG1073	alpha beta
SFUM_RS14775	COG0537	adenosine 5'-monophosphoramidase activity
SFUM_RS14790	COG0543	2 iron, 2 sulfur cluster binding
SFUM_RS14820	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SFUM_RS14825	COG0464	growth
SFUM_RS14835	COG0210	DNA helicase
SFUM_RS14845	COG0071	Belongs to the small heat shock protein (HSP20) family
SFUM_RS14860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SFUM_RS14880	COG1217	gtp-binding protein TYPA
SFUM_RS14920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SFUM_RS14930	COG1151	hydroxylamine reductase activity
SFUM_RS14935	COG3420	alginic acid biosynthetic process
SFUM_RS14955	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SFUM_RS14965	COG0564	pseudouridine synthase activity
SFUM_RS14975	COG0640	Transcriptional regulator
SFUM_RS14980	COG4232	protein-disulfide reductase activity
SFUM_RS14985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SFUM_RS14990	COG0573	inorganic phosphate transmembrane transporter activity
SFUM_RS14995	COG0581	inorganic phosphate transmembrane transporter activity
SFUM_RS15000	COG0704	Plays a role in the regulation of phosphate uptake
SFUM_RS15005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SFUM_RS15010	COG5002	protein histidine kinase activity
SFUM_RS15015	COG0745	RESPONSE REGULATOR receiver
SFUM_RS15025	COG1803	Methylglyoxal synthase
SFUM_RS15030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SFUM_RS15035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SFUM_RS15045	COG3842	ATPase activity
SFUM_RS15050	COG1840	ABC-type Fe3 transport system, periplasmic component
SFUM_RS15065	COG0688	phosphatidylethanolamine metabolic process
SFUM_RS15070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SFUM_RS15070	COG0438	transferase activity, transferring glycosyl groups
SFUM_RS15075	COG0704	Plays a role in the regulation of phosphate uptake
SFUM_RS15085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SFUM_RS15085	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SFUM_RS15100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SFUM_RS15120	COG0363	glucosamine-6-phosphate deaminase activity
SFUM_RS15125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SFUM_RS15150	COG0535	radical SAM domain protein
SFUM_RS15170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SFUM_RS15205	COG3256	nitric oxide reductase
SFUM_RS15220	COG1773	rubredoxin
SFUM_RS15245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SFUM_RS15250	COG2358	TRAP transporter, solute receptor (TAXI family
SFUM_RS15260	COG2084	Dehydrogenase
SFUM_RS15270	COG3383	formate dehydrogenase (NAD+) activity
SFUM_RS15275	COG3383	formate dehydrogenase (NAD+) activity
SFUM_RS15290	COG2848	UPF0210 protein
SFUM_RS15310	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SFUM_RS15315	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SFUM_RS15320	COG0745	RESPONSE REGULATOR receiver
SFUM_RS15325	COG2204	response regulator
SFUM_RS15335	COG0058	SHG alpha-glucan phosphorylase activity
SFUM_RS15350	COG0402	S-adenosylhomocysteine deaminase activity
SFUM_RS15355	COG0402	S-adenosylhomocysteine deaminase activity
SFUM_RS15365	COG1643	Atp-dependent helicase
SFUM_RS15390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SFUM_RS15395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SFUM_RS15420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SFUM_RS15425	COG0745	RESPONSE REGULATOR receiver
SFUM_RS15450	COG0440	acetolactate synthase activity
SFUM_RS15455	COG0028	Belongs to the TPP enzyme family
SFUM_RS15460	COG0028	Belongs to the TPP enzyme family
SFUM_RS15465	COG0440	acetolactate synthase activity
SFUM_RS15470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SFUM_RS15475	COG0688	phosphatidylethanolamine metabolic process
SFUM_RS15480	COG1183	phosphatidylcholine synthase activity
SFUM_RS15485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SFUM_RS15490	COG0066	3-isopropylmalate dehydratase activity
SFUM_RS15495	COG0473	3-isopropylmalate dehydrogenase activity
SFUM_RS15500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SFUM_RS15505	COG0742	ribosomal rna small subunit methyltransferase
SFUM_RS15510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SFUM_RS15515	COG2951	lytic endotransglycosylase activity
SFUM_RS15525	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SFUM_RS15530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SFUM_RS15535	COG0228	four-way junction DNA binding
SFUM_RS15540	COG1837	Belongs to the UPF0109 family
SFUM_RS15545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SFUM_RS15550	COG0336	Belongs to the RNA methyltransferase TrmD family
SFUM_RS15555	COG4752	Belongs to the RNA methyltransferase TrmD family
SFUM_RS15560	COG0335	large ribosomal subunit rRNA binding
SFUM_RS15565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SFUM_RS15570	COG0792	nuclease activity
SFUM_RS15575	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SFUM_RS15590	COG1294	oxidase, subunit
SFUM_RS15595	COG1271	oxidase subunit
SFUM_RS15600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SFUM_RS15605	COG2234	aminopeptidase activity
SFUM_RS15630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SFUM_RS15635	COG0745	RESPONSE REGULATOR receiver
SFUM_RS15660	COG0440	acetolactate synthase activity
SFUM_RS15665	COG0028	Belongs to the TPP enzyme family
SFUM_RS15670	COG0028	Belongs to the TPP enzyme family
SFUM_RS15675	COG0440	acetolactate synthase activity
SFUM_RS15680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SFUM_RS15685	COG0688	phosphatidylethanolamine metabolic process
SFUM_RS15690	COG1183	phosphatidylcholine synthase activity
SFUM_RS15695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SFUM_RS15700	COG0066	3-isopropylmalate dehydratase activity
SFUM_RS15705	COG0473	3-isopropylmalate dehydrogenase activity
SFUM_RS15710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SFUM_RS15715	COG0742	ribosomal rna small subunit methyltransferase
SFUM_RS15720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SFUM_RS15725	COG2951	lytic endotransglycosylase activity
SFUM_RS15735	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SFUM_RS15740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SFUM_RS15745	COG0228	four-way junction DNA binding
SFUM_RS15750	COG1837	Belongs to the UPF0109 family
SFUM_RS15755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SFUM_RS15760	COG0336	Belongs to the RNA methyltransferase TrmD family
SFUM_RS15765	COG4752	Belongs to the RNA methyltransferase TrmD family
SFUM_RS15770	COG0335	large ribosomal subunit rRNA binding
SFUM_RS15775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SFUM_RS15780	COG0792	nuclease activity
SFUM_RS15785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SFUM_RS15800	COG1294	oxidase, subunit
SFUM_RS15805	COG1271	oxidase subunit
SFUM_RS15810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SFUM_RS15815	COG2234	aminopeptidase activity
SFUM_RS15820	COG1285	pathogenesis
SFUM_RS15825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SFUM_RS15830	COG0535	radical SAM domain protein
SFUM_RS15835	COG0113	porphobilinogen synthase activity
SFUM_RS15840	COG0535	radical SAM domain protein
SFUM_RS15865	COG0793	Belongs to the peptidase S41A family
SFUM_RS15895	COG0427	acetyl-CoA hydrolase
SFUM_RS15900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SFUM_RS15910	COG1763	Mo-molybdopterin cofactor biosynthetic process
SFUM_RS15915	COG0746	molybdenum cofactor guanylyltransferase activity
SFUM_RS15920	COG0303	'Molybdopterin
SFUM_RS15925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SFUM_RS15925	COG1213	nucleotidyl transferase
SFUM_RS15950	COG0138	bifunctional purine biosynthesis protein purh
SFUM_RS15960	COG1830	Aldolase
SFUM_RS15975	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SFUM_RS15980	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SFUM_RS15985	COG1309	transcriptional regulator
SFUM_RS16015	COG0497	DNA recombination
SFUM_RS16020	COG2937	Belongs to the GPAT DAPAT family
SFUM_RS16025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SFUM_RS16035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SFUM_RS16050	COG4177	L-phenylalanine transmembrane transporter activity
SFUM_RS16060	COG0683	leucine binding
SFUM_RS16065	COG0686	Belongs to the AlaDH PNT family
SFUM_RS16080	COG5002	protein histidine kinase activity
SFUM_RS16105	COG0463	Glycosyl transferase, family 2
SFUM_RS16200	COG2081	HI0933 family
SFUM_RS16220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SFUM_RS16230	COG0674	pyruvate-flavodoxin oxidoreductase activity
SFUM_RS16230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SFUM_RS16235	COG1013	pyruvate-flavodoxin oxidoreductase activity
SFUM_RS16250	COG0446	pyridine nucleotide-disulphide oxidoreductase
SFUM_RS16250	COG1902	pentaerythritol trinitrate reductase activity
SFUM_RS16280	COG2186	Transcriptional regulator
SFUM_RS16315	COG2234	aminopeptidase activity
SFUM_RS16335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SFUM_RS16345	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SFUM_RS16350	COG1172	Belongs to the binding-protein-dependent transport system permease family
SFUM_RS16355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SFUM_RS16360	COG0765	amino acid transport
SFUM_RS16365	COG0765	amino acid transport
SFUM_RS16430	COG1404	Belongs to the peptidase S8 family
SFUM_RS16430	COG4412	M6 family metalloprotease domain protein
SFUM_RS16465	COG0196	riboflavin kinase activity
SFUM_RS16475	COG0305	Participates in initiation and elongation during chromosome replication
SFUM_RS16480	COG0359	binds to the 23S rRNA
SFUM_RS16490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SFUM_RS16495	COG0360	Binds together with S18 to 16S ribosomal RNA
SFUM_RS16510	COG1837	Belongs to the UPF0109 family
SFUM_RS16530	COG0243	molybdopterin cofactor binding
SFUM_RS16540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SFUM_RS16550	COG3344	reverse transcriptase
SFUM_RS16560	COG0181	hydroxymethylbilane synthase activity
SFUM_RS16580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SFUM_RS16620	COG1278	Cold shock
SFUM_RS16625	COG1090	epimerase
SFUM_RS16635	COG1141	Ferredoxin
SFUM_RS16660	COG1773	rubredoxin
SFUM_RS16665	COG2217	Heavy metal translocating P-type atpase
SFUM_RS16695	COG0612	Peptidase, M16
SFUM_RS16710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SFUM_RS16720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SFUM_RS16735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SFUM_RS16775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SFUM_RS16785	COG3191	aminopeptidase activity
SFUM_RS16805	COG1132	(ABC) transporter
SFUM_RS16815	COG1592	Rubrerythrin
SFUM_RS16820	COG0426	domain, Protein
SFUM_RS16840	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SFUM_RS16900	COG2204	response regulator
SFUM_RS16905	COG3852	Histidine kinase
SFUM_RS16915	COG2226	methyltransferase
SFUM_RS16920	COG2226	methyltransferase
SFUM_RS16925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SFUM_RS16940	COG0714	Associated with various cellular activities
SFUM_RS16945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SFUM_RS16950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SFUM_RS16955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SFUM_RS16960	COG1119	ATPase activity
SFUM_RS16965	COG1028	Short-chain dehydrogenase reductase Sdr
SFUM_RS16965	COG0604	alcohol dehydrogenase
SFUM_RS16965	COG3321	synthase
SFUM_RS16970	COG2003	Belongs to the UPF0758 family
SFUM_RS16975	COG2854	intermembrane phospholipid transfer
SFUM_RS16980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SFUM_RS16985	COG0437	4 iron, 4 sulfur cluster binding
SFUM_RS16990	COG0243	molybdopterin cofactor binding
SFUM_RS17025	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SFUM_RS17045	COG1324	tolerance protein
SFUM_RS17050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SFUM_RS17055	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SFUM_RS17060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SFUM_RS17065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SFUM_RS17070	COG0124	histidyl-tRNA synthetase
SFUM_RS17110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SFUM_RS17115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SFUM_RS17120	COG0583	DNA-binding transcription factor activity
SFUM_RS17125	COG0488	(ABC) transporter
SFUM_RS17130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SFUM_RS17135	COG1566	PFAM secretion protein HlyD family protein
SFUM_RS17140	COG2814	Major facilitator Superfamily
SFUM_RS17160	COG0489	protein tyrosine kinase activity
SFUM_RS17170	COG0484	heat shock protein binding
SFUM_RS17175	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SFUM_RS17175	COG0662	Cupin 2, conserved barrel domain protein
SFUM_RS17190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SFUM_RS17230	COG0297	glycogen (starch) synthase activity
SFUM_RS17230	COG0438	transferase activity, transferring glycosyl groups
SFUM_RS17270	COG0438	transferase activity, transferring glycosyl groups
SFUM_RS17305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SFUM_RS17315	COG1216	Glycosyl transferase, family 2
SFUM_RS17340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SFUM_RS17355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SFUM_RS17360	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SFUM_RS17375	COG2223	nitrite transmembrane transporter activity
SFUM_RS17385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SFUM_RS17390	COG0154	amidase activity
SFUM_RS17395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SFUM_RS17410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SFUM_RS17430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SFUM_RS17435	COG0205	6-phosphofructokinase activity
SFUM_RS17440	COG0702	epimerase
SFUM_RS17465	COG0546	phosphoglycolate phosphatase activity
SFUM_RS17490	COG0655	NAD(P)H dehydrogenase (quinone) activity
SFUM_RS17515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SFUM_RS17520	COG4336	lyase activity
SFUM_RS17525	COG1984	allophanate hydrolase subunit 2
SFUM_RS17530	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SFUM_RS17560	COG0709	Synthesizes selenophosphate from selenide and ATP
SFUM_RS17635	COG1363	Peptidase, m42
SFUM_RS17640	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SFUM_RS17650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SFUM_RS17665	COG4106	trans-aconitate 2-methyltransferase activity
SFUM_RS17670	COG0730	response to heat
SFUM_RS17690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SFUM_RS17710	COG1335	isochorismatase
SFUM_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
SFUM_RS17720	COG3647	Membrane
SFUM_RS17725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SFUM_RS17730	COG0631	protein serine/threonine phosphatase activity
SFUM_RS17735	COG1716	ATPase activity
SFUM_RS17740	COG2234	aminopeptidase activity
SFUM_RS17745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SFUM_RS17795	COG1151	hydroxylamine reductase activity
SFUM_RS17810	COG2032	superoxide dismutase activity
SFUM_RS17815	COG2270	Major facilitator Superfamily
SFUM_RS17820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SFUM_RS17825	COG1640	4-alpha-glucanotransferase
SFUM_RS17835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SFUM_RS17870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SFUM_RS17880	COG2001	Belongs to the MraZ family
SFUM_RS17885	COG0275	rRNA processing
SFUM_RS17900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SFUM_RS17905	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SFUM_RS17910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SFUM_RS17915	COG0772	Belongs to the SEDS family
SFUM_RS17920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SFUM_RS17925	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SFUM_RS17940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SFUM_RS17950	COG0484	heat shock protein binding
SFUM_RS17955	COG1921	L-seryl-tRNASec selenium transferase activity
SFUM_RS17970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SFUM_RS17985	COG4232	protein-disulfide reductase activity
SFUM_RS17995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SFUM_RS18020	COG1116	anion transmembrane transporter activity
SFUM_RS18025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SFUM_RS18050	COG3842	ATPase activity
SFUM_RS18065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SFUM_RS18075	COG2271	Major facilitator Superfamily
SFUM_RS18085	COG0154	amidase activity
SFUM_RS18090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SFUM_RS18110	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SFUM_RS18115	COG0352	thiamine-phosphate diphosphorylase activity
SFUM_RS18120	COG3383	formate dehydrogenase (NAD+) activity
SFUM_RS18135	COG0861	Integral membrane protein TerC family
SFUM_RS18155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SFUM_RS18160	COG2205	protein histidine kinase activity
SFUM_RS18175	COG4191	Histidine kinase
SFUM_RS18180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SFUM_RS18210	COG2223	nitrite transmembrane transporter activity
SFUM_RS18235	COG0247	lactate metabolic process
SFUM_RS18255	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SFUM_RS18260	COG3259	Nickel-dependent hydrogenase
SFUM_RS18270	COG2855	membrane
SFUM_RS18290	COG1966	Carbon starvation protein
SFUM_RS18295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SFUM_RS18305	COG4608	Belongs to the ABC transporter superfamily
SFUM_RS18310	COG0444	Belongs to the ABC transporter superfamily
SFUM_RS18325	COG0508	dehydrogenase complex catalyzes the overall conversion of
SFUM_RS18360	COG1132	(ABC) transporter
SFUM_RS18370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SFUM_RS18390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SFUM_RS18400	COG2226	methyltransferase
SFUM_RS18430	COG2226	methyltransferase
SFUM_RS18435	COG0436	Aminotransferase
SFUM_RS18455	COG3158	transport of potassium into the cell
SFUM_RS18470	COG2186	Transcriptional regulator
SFUM_RS18495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SFUM_RS18500	COG0183	Belongs to the thiolase family
SFUM_RS18505	COG1250	3-hydroxyacyl-CoA dehydrogenase
SFUM_RS18510	COG1024	Enoyl-CoA hydratase
SFUM_RS18515	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SFUM_RS18520	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SFUM_RS18525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SFUM_RS18530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SFUM_RS18550	COG0166	Belongs to the GPI family
SFUM_RS18580	COG0701	Predicted permease
SFUM_RS18600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SFUM_RS18605	COG0798	PFAM Bile acid sodium symporter
SFUM_RS18615	COG3118	belongs to the thioredoxin family
SFUM_RS18625	COG1321	iron dependent repressor
SFUM_RS18655	COG0489	protein tyrosine kinase activity
SFUM_RS18675	COG0745	RESPONSE REGULATOR receiver
SFUM_RS18695	COG0519	Catalyzes the synthesis of GMP from XMP
SFUM_RS18695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SFUM_RS18700	COG0531	amino acid
SFUM_RS18710	COG0655	NAD(P)H dehydrogenase (quinone) activity
SFUM_RS18730	COG3852	Histidine kinase
SFUM_RS18755	COG0084	hydrolase, TatD family'
SFUM_RS18760	COG0424	maF-like protein
SFUM_RS18765	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SFUM_RS18770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SFUM_RS18775	COG0194	GDP metabolic process
SFUM_RS18780	COG2052	Domain of unknown function (DUF370)
SFUM_RS18790	COG1561	YicC-like family, N-terminal region
SFUM_RS18800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SFUM_RS18800	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SFUM_RS18810	COG0762	integral membrane protein
SFUM_RS18820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SFUM_RS18825	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SFUM_RS18830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SFUM_RS18845	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SFUM_RS18850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SFUM_RS18855	COG0799	negative regulation of ribosome biogenesis
SFUM_RS18865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SFUM_RS18865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SFUM_RS18870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SFUM_RS18880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SFUM_RS18890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SFUM_RS18895	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SFUM_RS18900	COG0193	aminoacyl-tRNA hydrolase activity
SFUM_RS18905	COG1329	Transcriptional regulator
SFUM_RS18910	COG4956	integral membrane protein (PIN domain superfamily)
SFUM_RS18915	COG0564	pseudouridine synthase activity
SFUM_RS18955	COG1459	type II secretion system
SFUM_RS18960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SFUM_RS19015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SFUM_RS19020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SFUM_RS19055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SFUM_RS19060	COG2086	electron transfer activity
SFUM_RS19065	COG1960	acyl-CoA dehydrogenase activity
SFUM_RS19070	COG1309	transcriptional regulator
SFUM_RS19085	COG0107	imidazoleglycerol-phosphate synthase activity
SFUM_RS19110	COG0725	ABC transporter, periplasmic molybdate-binding protein
SFUM_RS19115	COG4149	molybdate abc transporter
SFUM_RS19125	COG4772	TonB-dependent receptor
SFUM_RS19145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFUM_RS19150	COG1120	ATPase activity
SFUM_RS19170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SFUM_RS19175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SFUM_RS19180	COG0512	Glutamine amidotransferase of anthranilate synthase
SFUM_RS19185	COG4106	trans-aconitate 2-methyltransferase activity
SFUM_RS19185	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SFUM_RS19190	COG0156	8-amino-7-oxononanoate synthase activity
SFUM_RS19220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SFUM_RS19225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SFUM_RS19245	COG2358	TRAP transporter, solute receptor (TAXI family
SFUM_RS19250	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SFUM_RS19265	COG0433	COG0433 Predicted ATPase
SFUM_RS19270	COG2223	nitrite transmembrane transporter activity
SFUM_RS19290	COG3189	MarR family transcriptional regulator
SFUM_RS19330	COG2204	response regulator
SFUM_RS19355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SFUM_RS19365	COG1136	(ABC) transporter
SFUM_RS19380	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SFUM_RS19385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SFUM_RS19390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SFUM_RS19400	COG0673	inositol 2-dehydrogenase activity
SFUM_RS19405	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SFUM_RS19410	COG1519	Transferase
SFUM_RS19455	COG1116	anion transmembrane transporter activity
SFUM_RS19470	COG2204	response regulator
SFUM_RS19475	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SFUM_RS19480	COG0287	Prephenate dehydrogenase
SFUM_RS19480	COG1605	Chorismate mutase
SFUM_RS19490	COG0653	protein targeting
SFUM_RS19525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SFUM_RS19540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SFUM_RS19590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SFUM_RS19595	COG0358	DNA primase activity
SFUM_RS19890	COG2815	serine threonine protein kinase
SFUM_RS19890	COG0515	serine threonine protein kinase
SFUM_RS19990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SFUM_RS19995	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SFUM_RS19995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SFUM_RS20005	COG0492	ferredoxin-NADP+ reductase activity
SFUM_RS20015	COG1595	DNA-templated transcription, initiation
SFUM_RS20085	COG2033	superoxide reductase activity
SFUM_RS20110	COG0538	isocitrate dehydrogenase activity
SFUM_RS20115	COG2264	protein methyltransferase activity
SFUM_RS20120	COG0436	Aminotransferase
SFUM_RS20125	COG0277	FAD linked oxidase domain protein
SFUM_RS20130	COG0765	amino acid transport
SFUM_RS20135	COG1126	abc transporter atp-binding protein
SFUM_RS20150	COG0251	oxidation-reduction process
SFUM_RS20165	COG0438	transferase activity, transferring glycosyl groups
SFUM_RS20180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SFUM_RS20185	COG3527	Alpha-acetolactate decarboxylase
SFUM_RS20195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SFUM_RS20200	COG2379	hydroxypyruvate reductase
SFUM_RS20255	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
SFUM_RS20260	COG0644	oxidoreductase
SFUM_RS20265	COG0644	oxidoreductase
SFUM_RS20280	COG1960	acyl-CoA dehydrogenase activity
SFUM_RS20295	COG3290	protein histidine kinase activity
SFUM_RS20295	COG3829	transcription factor binding
SFUM_RS20315	COG4651	solute:proton antiporter activity
SFUM_RS20315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SFUM_RS20345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SFUM_RS20370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SFUM_RS20375	COG0765	amino acid transport
SFUM_RS20395	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
SFUM_RS20405	COG0446	pyridine nucleotide-disulphide oxidoreductase
SFUM_RS20535	COG1132	(ABC) transporter
SFUM_RS20550	COG3290	protein histidine kinase activity
SFUM_RS20555	COG4565	transcriptional regulatory protein
SFUM_RS20560	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SFUM_RS20625	COG0668	transmembrane transport
SFUM_RS20630	COG0131	Imidazoleglycerol-phosphate dehydratase
SFUM_RS20670	COG0375	protein maturation
SFUM_RS20680	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SFUM_RS20685	COG0409	Hydrogenase expression formation protein
SFUM_RS20690	COG0309	Hydrogenase expression formation protein (HypE)
SFUM_RS20700	COG2223	nitrite transmembrane transporter activity
SFUM_RS20710	COG0488	(ABC) transporter
SFUM_RS20730	COG0012	GTP binding
SFUM_RS20740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SFUM_RS20765	COG1132	(ABC) transporter
SFUM_RS20775	COG1366	Belongs to the anti-sigma-factor antagonist family
SFUM_RS20795	COG1522	sequence-specific DNA binding
SFUM_RS20805	COG1047	Peptidyl-prolyl cis-trans
SFUM_RS20820	COG2221	Nitrite and sulphite reductase 4Fe-4S
SFUM_RS20825	COG2221	Nitrite and sulphite reductase 4Fe-4S
SFUM_RS20830	COG1797	cobyrinic acid a,c-diamide synthase activity
SFUM_RS20835	COG2920	part of a sulfur-relay system
SFUM_RS20840	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
SFUM_RS20865	COG1253	flavin adenine dinucleotide binding
SFUM_RS20870	COG0215	cysteine-tRNA ligase activity
SFUM_RS20875	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SFUM_RS20880	COG0436	Aminotransferase
SFUM_RS20890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SFUM_RS20895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SFUM_RS20900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SFUM_RS20905	COG0123	including yeast histone deacetylase and acetoin utilization protein
SFUM_RS20915	COG1077	Cell shape determining protein MreB Mrl
SFUM_RS20955	COG0463	Glycosyl transferase, family 2
SFUM_RS21010	COG1489	DNA binding
SFUM_RS21025	COG1872	DUF167
SFUM_RS21105	COG1053	succinate dehydrogenase
SFUM_RS21110	COG3118	belongs to the thioredoxin family
SFUM_RS21130	COG1469	GTP cyclohydrolase I activity
SFUM_RS21140	COG1181	Belongs to the D-alanine--D-alanine ligase family
SFUM_RS21210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFUM_RS21210	COG0649	NAD binding
SFUM_RS21210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFUM_RS21245	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SFUM_RS21255	COG1388	LysM domain
SFUM_RS21255	COG3942	CHAP domain
SFUM_RS21275	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SFUM_RS21285	COG0515	serine threonine protein kinase
SFUM_RS21285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SFUM_RS21290	COG4191	Histidine kinase
SFUM_RS21310	COG0726	polysaccharide deacetylase
SFUM_RS21315	COG3852	Histidine kinase
SFUM_RS21325	COG0826	peptidase U32
SFUM_RS21330	COG4251	negative regulation of phosphorylation
SFUM_RS21350	COG1388	LysM domain
SFUM_RS21350	COG1705	Flagellar rod assembly protein muramidase FlgJ
SFUM_RS21400	COG0584	glycerophosphoryl diester phosphodiesterase
SFUM_RS21410	COG4191	Histidine kinase
SFUM_RS21420	COG2226	methyltransferase
SFUM_RS21425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SFUM_RS21430	COG3409	Peptidoglycan-binding domain 1 protein
SFUM_RS21430	COG3267	Type II secretory pathway component ExeA
SFUM_RS21460	COG0577	efflux transmembrane transporter activity
SFUM_RS21460	COG1136	(ABC) transporter
SFUM_RS21475	COG2885	chlorophyll binding
SFUM_RS21540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SFUM_RS21560	COG4251	negative regulation of phosphorylation
SFUM_RS21595	COG3267	Type II secretory pathway component ExeA
SFUM_RS21595	COG3409	Peptidoglycan-binding domain 1 protein
SFUM_RS21600	COG1366	Belongs to the anti-sigma-factor antagonist family
SFUM_RS21615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SFUM_RS21625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SFUM_RS21625	COG1648	precorrin-2 dehydrogenase activity
SFUM_RS21640	COG3264	Mechanosensitive ion channel
SFUM_RS21640	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SFUM_RS21645	COG0643	Histidine kinase
SFUM_RS21645	COG0784	Response regulator, receiver
SFUM_RS21645	COG2198	Histidine kinase
SFUM_RS21650	COG2201	protein-glutamate methylesterase activity
SFUM_RS21655	COG2201	protein-glutamate methylesterase activity
SFUM_RS21675	COG0116	Belongs to the methyltransferase superfamily
SFUM_RS21680	COG0575	Belongs to the CDS family
SFUM_RS21715	COG1940	carbohydrate kinase activity
SFUM_RS21725	COG1309	transcriptional regulator
SFUM_RS21765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SFUM_RS21805	COG0535	radical SAM domain protein
SFUM_RS21815	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SFUM_RS21820	COG4191	Histidine kinase
SFUM_RS21820	COG0784	Response regulator, receiver
SFUM_RS21845	COG0515	serine threonine protein kinase
SFUM_RS21845	COG2815	serine threonine protein kinase
SFUM_RS21860	COG4968	Prepilin-type N-terminal cleavage methylation domain
SFUM_RS21870	COG0357	Ribosomal RNA small subunit methyltransferase G
SFUM_RS21875	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SFUM_RS21890	COG3706	GGDEF domain
SFUM_RS21895	COG4657	Part of a membrane complex involved in electron transport
SFUM_RS21920	COG4251	negative regulation of phosphorylation
SFUM_RS21960	COG0784	Response regulator, receiver
SFUM_RS21960	COG4191	Histidine kinase
SFUM_RS21970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SFUM_RS21980	COG2226	methyltransferase
SFUM_RS22005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SFUM_RS22010	COG2815	serine threonine protein kinase
SFUM_RS22010	COG0515	serine threonine protein kinase
SFUM_RS22025	COG2226	methyltransferase
SFUM_RS22030	COG1960	acyl-CoA dehydrogenase activity
SFUM_RS22050	COG0463	Glycosyl transferase, family 2
SFUM_RS22075	COG1309	transcriptional regulator
SFUM_RS22080	COG1381	Involved in DNA repair and RecF pathway recombination
SFUM_RS22085	COG3118	belongs to the thioredoxin family
SFUM_RS22090	COG0363	glucosamine-6-phosphate deaminase activity
SFUM_RS22105	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SFUM_RS22115	COG5002	protein histidine kinase activity
SFUM_RS22125	COG3599	regulation of cell shape
SFUM_RS22155	COG1028	Short-chain dehydrogenase reductase Sdr
SFUM_RS22160	COG1819	glycosyl
SFUM_RS22215	COG2770	Histidine kinase
SFUM_RS22215	COG2208	phosphoserine phosphatase activity
SFUM_RS22235	COG1686	Belongs to the peptidase S11 family