locus-tag	class	description
SWOL_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SWOL_RS00020	COG0592	DNA-directed DNA polymerase activity
SWOL_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SWOL_RS00035	COG0187	DNA topoisomerase II activity
SWOL_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SWOL_RS00045	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SWOL_RS00055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SWOL_RS00060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SWOL_RS00165	COG1309	transcriptional regulator
SWOL_RS00175	COG0116	Belongs to the methyltransferase superfamily
SWOL_RS00185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SWOL_RS00190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SWOL_RS00195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SWOL_RS00275	COG1982	Orn Lys Arg decarboxylase major
SWOL_RS00280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SWOL_RS00290	COG0470	DNA polymerase III
SWOL_RS00295	COG1774	PSP1 C-terminal conserved region
SWOL_RS00305	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SWOL_RS00310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SWOL_RS00315	COG2002	toxin-antitoxin pair type II binding
SWOL_RS00320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SWOL_RS00320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SWOL_RS00325	COG0084	hydrolase, TatD family'
SWOL_RS00330	COG3584	3D domain protein
SWOL_RS00330	COG3583	domain protein
SWOL_RS00340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SWOL_RS00345	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
SWOL_RS00350	COG4466	Protein conserved in bacteria
SWOL_RS00365	COG0438	transferase activity, transferring glycosyl groups
SWOL_RS00385	COG1752	Esterase of the alpha-beta hydrolase superfamily
SWOL_RS00395	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SWOL_RS00400	COG1802	Transcriptional regulator
SWOL_RS00410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SWOL_RS00415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SWOL_RS00420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SWOL_RS00425	COG0193	aminoacyl-tRNA hydrolase activity
SWOL_RS00430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SWOL_RS00460	COG0697	spore germination
SWOL_RS00470	COG2002	toxin-antitoxin pair type II binding
SWOL_RS00475	COG2244	polysaccharide biosynthetic process
SWOL_RS00480	COG3956	TIGRFAM MazG family protein
SWOL_RS00490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SWOL_RS00515	COG1098	S1 RNA binding domain
SWOL_RS00520	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SWOL_RS00520	COG0248	Ppx GppA phosphatase
SWOL_RS00525	COG2116	formate transmembrane transporter activity
SWOL_RS00535	COG0037	tRNA processing
SWOL_RS00545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SWOL_RS00550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SWOL_RS00555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SWOL_RS00570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SWOL_RS00575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SWOL_RS00580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SWOL_RS00585	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SWOL_RS00590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SWOL_RS00605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SWOL_RS00610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SWOL_RS00630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SWOL_RS00635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SWOL_RS00640	COG1696	Membrane protein involved in D-alanine export
SWOL_RS00665	COG0728	peptidoglycan biosynthetic process
SWOL_RS00675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SWOL_RS00695	COG1086	Polysaccharide biosynthesis protein
SWOL_RS00705	COG1361	Conserved repeat domain
SWOL_RS00740	COG1943	Transposase
SWOL_RS00795	COG5464	transposase or invertase
SWOL_RS00800	COG1943	Transposase
SWOL_RS00835	COG3328	transposase activity
SWOL_RS00955	COG1131	(ABC) transporter
SWOL_RS00965	COG0842	Transport permease protein
SWOL_RS00975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SWOL_RS00990	COG2197	response regulator
SWOL_RS01000	COG1040	competence protein
SWOL_RS01025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SWOL_RS01035	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SWOL_RS01040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SWOL_RS01045	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SWOL_RS01045	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SWOL_RS01065	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
SWOL_RS01075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SWOL_RS01110	COG2089	acid synthase
SWOL_RS01120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SWOL_RS01165	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
SWOL_RS01175	COG1192	Involved in chromosome partitioning
SWOL_RS01195	COG1086	Polysaccharide biosynthesis protein
SWOL_RS01205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SWOL_RS01245	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SWOL_RS01250	COG0653	protein targeting
SWOL_RS01255	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SWOL_RS01265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SWOL_RS01270	COG3959	Transketolase, thiamine diphosphate binding domain
SWOL_RS01275	COG3958	Transketolase
SWOL_RS01280	COG2884	Cell division ATP-binding protein ftsE
SWOL_RS01285	COG2177	Part of the ABC transporter FtsEX involved in
SWOL_RS01290	COG0739	heme binding
SWOL_RS01290	COG1196	nuclear chromosome segregation
SWOL_RS01290	COG0741	lytic transglycosylase activity
SWOL_RS01295	COG0793	Belongs to the peptidase S41A family
SWOL_RS01300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SWOL_RS01310	COG0556	nucleotide-excision repair
SWOL_RS01315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SWOL_RS01320	COG0322	excinuclease ABC activity
SWOL_RS01325	COG1950	PFAM Membrane protein of
SWOL_RS01340	COG0561	phosphatase activity
SWOL_RS01350	COG2222	sugar isomerase
SWOL_RS01360	COG1660	Displays ATPase and GTPase activities
SWOL_RS01365	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SWOL_RS01370	COG1481	regulation of sporulation
SWOL_RS01375	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SWOL_RS01380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SWOL_RS01385	COG2086	electron transfer activity
SWOL_RS01390	COG1960	acyl-CoA dehydrogenase activity
SWOL_RS01395	COG1846	Transcriptional regulator
SWOL_RS01415	COG0126	phosphoglycerate kinase activity
SWOL_RS01420	COG0149	triose-phosphate isomerase activity
SWOL_RS01425	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SWOL_RS01430	COG0148	phosphopyruvate hydratase activity
SWOL_RS01435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SWOL_RS01450	COG0557	exoribonuclease II activity
SWOL_RS01455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SWOL_RS01525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SWOL_RS01560	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SWOL_RS01565	COG3290	protein histidine kinase activity
SWOL_RS01565	COG3829	transcription factor binding
SWOL_RS01570	COG1250	3-hydroxyacyl-CoA dehydrogenase
SWOL_RS01575	COG0183	Belongs to the thiolase family
SWOL_RS01580	COG0427	acetyl-CoA hydrolase
SWOL_RS01600	COG0534	Mate efflux family protein
SWOL_RS01605	COG1126	abc transporter atp-binding protein
SWOL_RS01610	COG0765	amino acid transport
SWOL_RS01615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SWOL_RS01625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SWOL_RS01640	COG2323	membrane
SWOL_RS01655	COG1122	ATPase activity
SWOL_RS01660	COG4120	Belongs to the binding-protein-dependent transport system permease family
SWOL_RS01690	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SWOL_RS01695	COG0745	RESPONSE REGULATOR receiver
SWOL_RS01720	COG1116	anion transmembrane transporter activity
SWOL_RS01725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SWOL_RS01735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SWOL_RS01750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SWOL_RS01755	COG2894	cell division
SWOL_RS01760	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SWOL_RS01765	COG2199	diguanylate cyclase activity
SWOL_RS01765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SWOL_RS01785	COG0659	secondary active sulfate transmembrane transporter activity
SWOL_RS01820	COG2201	protein-glutamate methylesterase activity
SWOL_RS01825	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SWOL_RS01835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SWOL_RS01840	COG0134	indole-3-glycerol-phosphate synthase activity
SWOL_RS01845	COG0135	phosphoribosylanthranilate isomerase activity
SWOL_RS01850	COG0133	tryptophan synthase activity
SWOL_RS01855	COG0159	tryptophan synthase activity
SWOL_RS01860	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SWOL_RS01865	COG0512	Glutamine amidotransferase of anthranilate synthase
SWOL_RS01865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SWOL_RS01890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SWOL_RS01895	COG1811	Na channel or pump
SWOL_RS01900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SWOL_RS01905	COG0154	amidase activity
SWOL_RS01910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SWOL_RS01915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SWOL_RS01925	COG0066	3-isopropylmalate dehydratase activity
SWOL_RS01930	COG0538	isocitrate dehydrogenase activity
SWOL_RS01935	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SWOL_RS01940	COG0784	Response regulator, receiver
SWOL_RS01940	COG5002	protein histidine kinase activity
SWOL_RS01955	COG1960	acyl-CoA dehydrogenase activity
SWOL_RS01965	COG1077	Cell shape determining protein MreB Mrl
SWOL_RS01995	COG4115	mRNA cleavage
SWOL_RS02045	COG2871	sodium ion transport
SWOL_RS02055	COG0395	ABC-type sugar transport system, permease component
SWOL_RS02060	COG1175	transmembrane transport
SWOL_RS02070	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SWOL_RS02080	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SWOL_RS02085	COG3842	ATPase activity
SWOL_RS02090	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SWOL_RS02115	COG1129	ABC transporter
SWOL_RS02130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SWOL_RS02135	COG5012	cobalamin binding
SWOL_RS02170	COG1172	Belongs to the binding-protein-dependent transport system permease family
SWOL_RS02175	COG1129	ABC transporter
SWOL_RS02180	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SWOL_RS02185	COG1924	4 iron, 4 sulfur cluster binding
SWOL_RS02205	COG2801	Transposase and inactivated derivatives
SWOL_RS02230	COG1250	3-hydroxyacyl-CoA dehydrogenase
SWOL_RS02235	COG0427	acetyl-CoA hydrolase
SWOL_RS02240	COG3290	protein histidine kinase activity
SWOL_RS02240	COG3829	transcription factor binding
SWOL_RS02245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SWOL_RS02260	COG1307	EDD domain protein, DegV family
SWOL_RS02265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SWOL_RS02270	COG3279	Response regulator of the LytR AlgR family
SWOL_RS02280	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SWOL_RS02280	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SWOL_RS02300	COG1924	4 iron, 4 sulfur cluster binding
SWOL_RS02305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SWOL_RS02310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SWOL_RS02320	COG3290	protein histidine kinase activity
SWOL_RS02320	COG3829	transcription factor binding
SWOL_RS02345	COG1937	Protein conserved in bacteria
SWOL_RS02350	COG3118	belongs to the thioredoxin family
SWOL_RS02360	COG0482	sulfurtransferase activity
SWOL_RS02370	COG0628	permease
SWOL_RS02375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SWOL_RS02380	COG4472	Bacterial protein of unknown function (DUF965)
SWOL_RS02385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SWOL_RS02390	COG3906	Belongs to the UPF0473 family
SWOL_RS02395	COG2720	vancomycin resistance protein
SWOL_RS02400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SWOL_RS02405	COG0826	peptidase U32
SWOL_RS02435	COG1518	maintenance of DNA repeat elements
SWOL_RS02450	COG3093	addiction module antidote protein HigA
SWOL_RS02475	COG1960	acyl-CoA dehydrogenase activity
SWOL_RS02480	COG0768	penicillin binding
SWOL_RS02485	COG0443	Heat shock 70 kDa protein
SWOL_RS02500	COG0542	response to heat
SWOL_RS02560	COG0210	DNA helicase
SWOL_RS02580	COG0513	Belongs to the DEAD box helicase family
SWOL_RS02610	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SWOL_RS02630	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SWOL_RS02655	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SWOL_RS02660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SWOL_RS02670	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SWOL_RS02675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SWOL_RS02680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SWOL_RS02685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SWOL_RS02700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SWOL_RS02710	COG1459	type II secretion system
SWOL_RS02715	COG4968	Prepilin-type N-terminal cleavage methylation domain
SWOL_RS02735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SWOL_RS02755	COG0312	modulator of DNA gyrase
SWOL_RS02760	COG0312	modulator of DNA gyrase
SWOL_RS02765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SWOL_RS02775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SWOL_RS02795	COG3854	ATPases associated with a variety of cellular activities
SWOL_RS02835	COG5016	pyruvate
SWOL_RS02835	COG0511	ligase activity, forming carbon-carbon bonds
SWOL_RS02840	COG0439	Biotin carboxylase
SWOL_RS02845	COG1302	Protein conserved in bacteria
SWOL_RS02860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SWOL_RS02865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SWOL_RS02870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SWOL_RS02875	COG1570	exodeoxyribonuclease VII activity
SWOL_RS02880	COG1722	exodeoxyribonuclease VII activity
SWOL_RS02915	COG0534	Mate efflux family protein
SWOL_RS02930	COG1331	Highly conserved protein containing a thioredoxin domain
SWOL_RS02950	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SWOL_RS02955	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SWOL_RS02960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SWOL_RS02965	COG1438	arginine binding
SWOL_RS02975	COG0497	DNA recombination
SWOL_RS02980	COG0071	Belongs to the small heat shock protein (HSP20) family
SWOL_RS02985	COG0750	zinc metalloprotease
SWOL_RS02990	COG0745	RESPONSE REGULATOR receiver
SWOL_RS03015	COG2195	Cleaves the N-terminal amino acid of tripeptides
SWOL_RS03030	COG1379	DNA repair
SWOL_RS03065	COG1300	Membrane
SWOL_RS03075	COG4974	Belongs to the 'phage' integrase family
SWOL_RS03080	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SWOL_RS03100	COG1686	Belongs to the peptidase S11 family
SWOL_RS03110	COG2172	sigma factor antagonist activity
SWOL_RS03115	COG1191	sigma factor activity
SWOL_RS03130	COG1088	dTDP-glucose 4,6-dehydratase activity
SWOL_RS03135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SWOL_RS03140	COG1598	PFAM Uncharacterised protein family UPF0150
SWOL_RS03175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SWOL_RS03185	COG0697	spore germination
SWOL_RS03200	COG1924	4 iron, 4 sulfur cluster binding
SWOL_RS03230	COG0351	phosphomethylpyrimidine kinase
SWOL_RS03235	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SWOL_RS03240	COG0352	thiamine-phosphate diphosphorylase activity
SWOL_RS03245	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
SWOL_RS03250	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SWOL_RS03255	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SWOL_RS03265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SWOL_RS03275	COG0776	regulation of translation
SWOL_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
SWOL_RS03305	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SWOL_RS03315	COG3679	Belongs to the UPF0342 family
SWOL_RS03340	COG0735	belongs to the Fur family
SWOL_RS03345	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SWOL_RS03355	COG0489	protein tyrosine kinase activity
SWOL_RS03365	COG0719	Fe-S assembly protein
SWOL_RS03370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SWOL_RS03370	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SWOL_RS03380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SWOL_RS03385	COG0010	Belongs to the arginase family
SWOL_RS03390	COG1592	Rubrerythrin
SWOL_RS03400	COG0180	Tryptophanyl-tRNA synthetase
SWOL_RS03410	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SWOL_RS03415	COG0183	Belongs to the thiolase family
SWOL_RS03425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SWOL_RS03435	COG0163	prenyltransferase activity
SWOL_RS03445	COG0805	protein transport
SWOL_RS03450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SWOL_RS03455	COG1648	precorrin-2 dehydrogenase activity
SWOL_RS03455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SWOL_RS03460	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SWOL_RS03465	COG0181	hydroxymethylbilane synthase activity
SWOL_RS03480	COG0535	radical SAM domain protein
SWOL_RS03485	COG0113	porphobilinogen synthase activity
SWOL_RS03490	COG0535	radical SAM domain protein
SWOL_RS03495	COG1522	sequence-specific DNA binding
SWOL_RS03505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SWOL_RS03510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SWOL_RS03515	COG2086	electron transfer activity
SWOL_RS03520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SWOL_RS03525	COG0247	lactate metabolic process
SWOL_RS03525	COG2181	nitrate reductase activity
SWOL_RS03530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SWOL_RS03570	COG0673	inositol 2-dehydrogenase activity
SWOL_RS03575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SWOL_RS03580	COG0579	oxidoreductase
SWOL_RS03590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SWOL_RS03595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SWOL_RS03600	COG0367	asparagine synthase
SWOL_RS03625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SWOL_RS03690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SWOL_RS03715	COG4974	Belongs to the 'phage' integrase family
SWOL_RS03725	COG4974	Belongs to the 'phage' integrase family
SWOL_RS03735	COG4974	Belongs to the 'phage' integrase family
SWOL_RS03755	COG1192	Involved in chromosome partitioning
SWOL_RS03805	COG1361	Conserved repeat domain
SWOL_RS03810	COG3584	3D domain protein
SWOL_RS03810	COG3583	domain protein
SWOL_RS03820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SWOL_RS03825	COG1302	Protein conserved in bacteria
SWOL_RS03830	COG1461	Dihydroxyacetone kinase
SWOL_RS03840	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SWOL_RS03845	COG0742	ribosomal rna small subunit methyltransferase
SWOL_RS03855	COG3314	Sporulation integral membrane protein YlbJ
SWOL_RS03860	COG1752	Esterase of the alpha-beta hydrolase superfamily
SWOL_RS03870	COG1323	Belongs to the UPF0348 family
SWOL_RS03875	COG0280	phosphate acetyltransferase
SWOL_RS03880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SWOL_RS03890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SWOL_RS03895	COG0416	fatty acid biosynthetic process
SWOL_RS03900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SWOL_RS03905	COG0571	ribonuclease III activity
SWOL_RS03920	COG1196	nuclear chromosome segregation
SWOL_RS03925	COG0552	protein localization to endoplasmic reticulum
SWOL_RS03930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SWOL_RS03935	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SWOL_RS03945	COG0402	S-adenosylhomocysteine deaminase activity
SWOL_RS03955	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SWOL_RS03970	COG3383	formate dehydrogenase (NAD+) activity
SWOL_RS03975	COG0427	acetyl-CoA hydrolase
SWOL_RS03980	COG1960	acyl-CoA dehydrogenase activity
SWOL_RS03985	COG0183	Belongs to the thiolase family
SWOL_RS03990	COG1024	Enoyl-CoA hydratase
SWOL_RS03995	COG1250	3-hydroxyacyl-CoA dehydrogenase
SWOL_RS04000	COG3290	protein histidine kinase activity
SWOL_RS04000	COG3829	transcription factor binding
SWOL_RS04015	COG1598	PFAM Uncharacterised protein family UPF0150
SWOL_RS04025	COG2864	formate dehydrogenase
SWOL_RS04030	COG0437	4 iron, 4 sulfur cluster binding
SWOL_RS04045	COG0303	'Molybdopterin
SWOL_RS04050	COG0303	'Molybdopterin
SWOL_RS04070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SWOL_RS04075	COG1490	D-aminoacyl-tRNA deacylase activity
SWOL_RS04080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SWOL_RS04085	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SWOL_RS04090	COG0077	Prephenate dehydratase
SWOL_RS04095	COG0124	histidyl-tRNA synthetase
SWOL_RS04100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SWOL_RS04105	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SWOL_RS04110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SWOL_RS04115	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SWOL_RS04125	COG2001	Belongs to the MraZ family
SWOL_RS04140	COG0768	penicillin binding
SWOL_RS04145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SWOL_RS04150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SWOL_RS04155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SWOL_RS04160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SWOL_RS04165	COG0772	Belongs to the SEDS family
SWOL_RS04170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SWOL_RS04175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SWOL_RS04180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SWOL_RS04185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SWOL_RS04195	COG3856	small basic protein
SWOL_RS04205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SWOL_RS04215	COG1191	sigma factor activity
SWOL_RS04220	COG1191	sigma factor activity
SWOL_RS04235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SWOL_RS04235	COG0758	DNA mediated transformation
SWOL_RS04240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SWOL_RS04245	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SWOL_RS04250	COG4974	Belongs to the 'phage' integrase family
SWOL_RS04255	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SWOL_RS04260	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SWOL_RS04270	COG1815	bacterial-type flagellum-dependent cell motility
SWOL_RS04280	COG1677	Flagellar hook-basal body complex protein FliE
SWOL_RS04285	COG1766	The M ring may be actively involved in energy transduction
SWOL_RS04300	COG1157	protein secretion by the type III secretion system
SWOL_RS04345	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SWOL_RS04350	COG1776	CheC inhibitor of MCP methylation
SWOL_RS04350	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SWOL_RS04355	COG2201	protein-glutamate methylesterase activity
SWOL_RS04365	COG1338	Plays a role in the flagellum-specific transport system
SWOL_RS04370	COG1987	bacterial-type flagellum assembly
SWOL_RS04375	COG1684	flagellar biosynthetic protein fliR
SWOL_RS04380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SWOL_RS04385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SWOL_RS04390	COG1419	protein localization to endoplasmic reticulum
SWOL_RS04395	COG0455	bacterial-type flagellum organization
SWOL_RS04405	COG2201	protein-glutamate methylesterase activity
SWOL_RS04410	COG2198	Histidine kinase
SWOL_RS04410	COG0643	Histidine kinase
SWOL_RS04415	COG0835	chemotaxis
SWOL_RS04420	COG1776	CheC inhibitor of MCP methylation
SWOL_RS04425	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SWOL_RS04430	COG1191	sigma factor activity
SWOL_RS04450	COG0052	Belongs to the universal ribosomal protein uS2 family
SWOL_RS04455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SWOL_RS04460	COG0528	UMP kinase activity
SWOL_RS04465	COG0233	cytoplasmic translational termination
SWOL_RS04470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SWOL_RS04475	COG4589	Belongs to the CDS family
SWOL_RS04480	COG0628	permease
SWOL_RS04485	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SWOL_RS04490	COG0750	zinc metalloprotease
SWOL_RS04495	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SWOL_RS04500	COG0442	prolyl-tRNA aminoacylation
SWOL_RS04505	COG1285	pathogenesis
SWOL_RS04510	COG2176	DNA-directed DNA polymerase activity
SWOL_RS04515	COG0779	Required for maturation of 30S ribosomal subunits
SWOL_RS04520	COG0195	Participates in both transcription termination and antitermination
SWOL_RS04525	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SWOL_RS04535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SWOL_RS04540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SWOL_RS04545	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SWOL_RS04550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SWOL_RS04555	COG0196	riboflavin kinase activity
SWOL_RS04560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SWOL_RS04565	COG1185	polyribonucleotide nucleotidyltransferase activity
SWOL_RS04575	COG0726	polysaccharide deacetylase
SWOL_RS04580	COG1686	Belongs to the peptidase S11 family
SWOL_RS04585	COG0612	Peptidase, M16
SWOL_RS04590	COG0756	dUTP diphosphatase activity
SWOL_RS04595	COG1873	PFAM PRC-barrel domain
SWOL_RS04600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SWOL_RS04605	COG0569	domain protein
SWOL_RS04615	COG0517	IMP dehydrogenase activity
SWOL_RS04615	COG0516	GMP reductase activity
SWOL_RS04620	COG1285	pathogenesis
SWOL_RS04640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SWOL_RS04645	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SWOL_RS04655	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SWOL_RS04660	COG1067	ATP-dependent peptidase activity
SWOL_RS04670	COG3290	protein histidine kinase activity
SWOL_RS04670	COG0840	transmembrane signaling receptor activity
SWOL_RS04685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SWOL_RS04745	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SWOL_RS04750	COG0583	DNA-binding transcription factor activity
SWOL_RS04770	COG0798	PFAM Bile acid sodium symporter
SWOL_RS04775	COG0673	inositol 2-dehydrogenase activity
SWOL_RS04780	COG1136	(ABC) transporter
SWOL_RS04790	COG0577	efflux transmembrane transporter activity
SWOL_RS04795	COG1191	sigma factor activity
SWOL_RS04810	COG4786	Flagellar basal body rod
SWOL_RS04815	COG1873	PFAM PRC-barrel domain
SWOL_RS04820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SWOL_RS04830	COG0745	RESPONSE REGULATOR receiver
SWOL_RS04835	COG5002	protein histidine kinase activity
SWOL_RS04840	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SWOL_RS04845	COG1799	cell septum assembly
SWOL_RS04850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SWOL_RS04860	COG0826	peptidase U32
SWOL_RS04865	COG3599	regulation of cell shape
SWOL_RS04870	COG1872	DUF167
SWOL_RS04880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SWOL_RS04885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SWOL_RS04895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SWOL_RS04900	COG0438	transferase activity, transferring glycosyl groups
SWOL_RS04925	COG4224	UPF0291 protein
SWOL_RS04935	COG0840	transmembrane signaling receptor activity
SWOL_RS04940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SWOL_RS04945	COG3679	Belongs to the UPF0342 family
SWOL_RS04950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SWOL_RS04965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SWOL_RS04970	COG2136	Putative SAM-dependent methyltransferase
SWOL_RS04970	COG2521	methyltransferase
SWOL_RS04975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SWOL_RS04980	COG1923	regulation of RNA biosynthetic process
SWOL_RS04995	COG0464	growth
SWOL_RS05000	COG1373	ATPase (AAA superfamily
SWOL_RS05070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SWOL_RS05075	COG0537	adenosine 5'-monophosphoramidase activity
SWOL_RS05105	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SWOL_RS05120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SWOL_RS05125	COG1598	PFAM Uncharacterised protein family UPF0150
SWOL_RS05140	COG0247	lactate metabolic process
SWOL_RS05145	COG0277	FAD linked oxidase domain protein
SWOL_RS05150	COG0427	acetyl-CoA hydrolase
SWOL_RS05155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SWOL_RS05180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SWOL_RS05210	COG0303	'Molybdopterin
SWOL_RS05220	COG3383	formate dehydrogenase (NAD+) activity
SWOL_RS05230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SWOL_RS05235	COG1183	phosphatidylcholine synthase activity
SWOL_RS05260	COG3344	reverse transcriptase
SWOL_RS05315	COG1882	Formate acetyltransferase
SWOL_RS05325	COG1307	EDD domain protein, DegV family
SWOL_RS05345	COG5002	protein histidine kinase activity
SWOL_RS05360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SWOL_RS05365	COG0765	amino acid transport
SWOL_RS05395	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SWOL_RS05425	COG0726	polysaccharide deacetylase
SWOL_RS05435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SWOL_RS05440	COG0765	amino acid transport
SWOL_RS05445	COG1126	abc transporter atp-binding protein
SWOL_RS05490	COG2909	trisaccharide binding
SWOL_RS05500	COG2239	Acts as a magnesium transporter
SWOL_RS05525	COG1404	Belongs to the peptidase S8 family
SWOL_RS05545	COG4399	Belongs to the UPF0754 family
SWOL_RS05550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SWOL_RS05560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SWOL_RS05565	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SWOL_RS05570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SWOL_RS05575	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SWOL_RS05580	COG0072	phenylalanine-tRNA ligase activity
SWOL_RS05580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SWOL_RS05590	COG2239	Acts as a magnesium transporter
SWOL_RS05600	COG3243	poly(R)-hydroxyalkanoic acid synthase
SWOL_RS05605	COG0741	lytic transglycosylase activity
SWOL_RS05610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SWOL_RS05625	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SWOL_RS05630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SWOL_RS05630	COG1796	DNA polymerase
SWOL_RS05635	COG2323	membrane
SWOL_RS05640	COG0826	peptidase U32
SWOL_RS05645	COG1193	negative regulation of DNA recombination
SWOL_RS05655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SWOL_RS05685	COG1435	thymidine kinase activity
SWOL_RS05735	COG1509	lysine 2,3-aminomutase activity
SWOL_RS05740	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SWOL_RS05745	COG3285	dna ligase
SWOL_RS05745	COG1793	dna ligase
SWOL_RS05750	COG1793	dna ligase
SWOL_RS05750	COG3285	dna ligase
SWOL_RS05760	COG2814	Major facilitator Superfamily
SWOL_RS05775	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SWOL_RS05795	COG1199	ATP-dependent helicase activity
SWOL_RS05825	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SWOL_RS05825	COG3608	succinylglutamate desuccinylase aspartoacylase
SWOL_RS05845	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SWOL_RS05860	COG0318	PFAM AMP-dependent synthetase and ligase
SWOL_RS05870	COG1074	ATP-dependent DNA helicase activity
SWOL_RS05875	COG0427	acetyl-CoA hydrolase
SWOL_RS05890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SWOL_RS05900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SWOL_RS05910	COG0668	transmembrane transport
SWOL_RS05920	COG1181	Belongs to the D-alanine--D-alanine ligase family
SWOL_RS05925	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SWOL_RS05930	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SWOL_RS05935	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SWOL_RS05945	COG1615	UPF0182 protein
SWOL_RS05960	COG1683	Conserved Protein
SWOL_RS05985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SWOL_RS05995	COG1250	3-hydroxyacyl-CoA dehydrogenase
SWOL_RS06005	COG0012	GTP binding
SWOL_RS06010	COG0189	ligase activity
SWOL_RS06035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SWOL_RS06035	COG4651	solute:proton antiporter activity
SWOL_RS06080	COG1704	LemA family
SWOL_RS06110	COG0583	DNA-binding transcription factor activity
SWOL_RS06130	COG0697	spore germination
SWOL_RS06150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SWOL_RS06155	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SWOL_RS06175	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SWOL_RS06185	COG0436	Aminotransferase
SWOL_RS06190	COG1522	sequence-specific DNA binding
SWOL_RS06220	COG0708	Exodeoxyribonuclease III
SWOL_RS06240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SWOL_RS06250	COG0500	methyltransferase
SWOL_RS06265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SWOL_RS06270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SWOL_RS06270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SWOL_RS06285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SWOL_RS06290	COG1162	GTPase activity
SWOL_RS06295	COG0515	serine threonine protein kinase
SWOL_RS06295	COG2815	serine threonine protein kinase
SWOL_RS06300	COG0631	protein serine/threonine phosphatase activity
SWOL_RS06305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SWOL_RS06310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SWOL_RS06310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SWOL_RS06315	COG2738	Putative neutral zinc metallopeptidase
SWOL_RS06325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SWOL_RS06330	COG0242	peptide deformylase activity
SWOL_RS06335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SWOL_RS06340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SWOL_RS06345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SWOL_RS06350	COG1758	RNA polymerase activity
SWOL_RS06355	COG0194	GDP metabolic process
SWOL_RS06360	COG2052	Domain of unknown function (DUF370)
SWOL_RS06365	COG1561	YicC-like family, N-terminal region
SWOL_RS06370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SWOL_RS06375	COG3243	poly(R)-hydroxyalkanoic acid synthase
SWOL_RS06380	COG2030	dehydratase
SWOL_RS06410	COG0613	PHP domain protein
SWOL_RS06420	COG2359	stage V sporulation protein S
SWOL_RS06425	COG1692	metallophosphoesterase
SWOL_RS06435	COG3344	reverse transcriptase
SWOL_RS06445	COG1418	mRNA catabolic process
SWOL_RS06450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SWOL_RS06455	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SWOL_RS06460	COG1058	Belongs to the CinA family
SWOL_RS06460	COG1546	Belongs to the CinA family
SWOL_RS06465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SWOL_RS06475	COG1361	Conserved repeat domain
SWOL_RS06480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SWOL_RS06485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SWOL_RS06495	COG1522	sequence-specific DNA binding
SWOL_RS06495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SWOL_RS06500	COG1674	ftsk spoiiie
SWOL_RS06505	COG1968	undecaprenyl-diphosphatase activity
SWOL_RS06515	COG0740	serine-type endopeptidase activity
SWOL_RS06520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SWOL_RS06525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SWOL_RS06530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SWOL_RS06535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SWOL_RS06540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SWOL_RS06545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SWOL_RS06565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SWOL_RS06570	COG0284	orotidine-5'-phosphate decarboxylase activity
SWOL_RS06575	COG0167	dihydroorotate dehydrogenase activity
SWOL_RS06580	COG0543	2 iron, 2 sulfur cluster binding
SWOL_RS06585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SWOL_RS06590	COG0505	Belongs to the CarA family
SWOL_RS06595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SWOL_RS06600	COG0540	Belongs to the ATCase OTCase family
SWOL_RS06605	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SWOL_RS06610	COG0564	pseudouridine synthase activity
SWOL_RS06615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SWOL_RS06630	COG4512	PFAM Accessory gene regulator B
SWOL_RS06635	COG3290	protein histidine kinase activity
SWOL_RS06655	COG1959	2 iron, 2 sulfur cluster binding
SWOL_RS06665	COG2361	Protein of unknown function DUF86
SWOL_RS06705	COG0492	ferredoxin-NADP+ reductase activity
SWOL_RS06710	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SWOL_RS06805	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SWOL_RS06820	COG0083	homoserine kinase activity
SWOL_RS06825	COG0460	homoserine dehydrogenase
SWOL_RS06845	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SWOL_RS06850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SWOL_RS06855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SWOL_RS06870	COG0745	RESPONSE REGULATOR receiver
SWOL_RS06880	COG2201	protein-glutamate methylesterase activity
SWOL_RS06890	COG0840	transmembrane signaling receptor activity
SWOL_RS06895	COG2198	Histidine kinase
SWOL_RS06895	COG0643	Histidine kinase
SWOL_RS06900	COG2201	protein-glutamate methylesterase activity
SWOL_RS06940	COG1304	FMN binding
SWOL_RS06955	COG0539	negative regulation of cytoplasmic translation
SWOL_RS06955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SWOL_RS06965	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SWOL_RS06970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SWOL_RS06975	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SWOL_RS06980	COG0287	Prephenate dehydrogenase
SWOL_RS06985	COG0189	ligase activity
SWOL_RS06985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SWOL_RS06990	COG4242	Belongs to the peptidase S51 family
SWOL_RS06995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SWOL_RS07005	COG0723	plastoquinol--plastocyanin reductase activity
SWOL_RS07005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SWOL_RS07010	COG2814	Major facilitator Superfamily
SWOL_RS07015	COG2030	dehydratase
SWOL_RS07020	COG2030	dehydratase
SWOL_RS07025	COG1982	Orn Lys Arg decarboxylase major
SWOL_RS07045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SWOL_RS07050	COG2378	regulation of single-species biofilm formation
SWOL_RS07065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SWOL_RS07110	COG1013	pyruvate-flavodoxin oxidoreductase activity
SWOL_RS07115	COG0674	pyruvate-flavodoxin oxidoreductase activity
SWOL_RS07125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SWOL_RS07160	COG1725	Transcriptional regulator
SWOL_RS07190	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SWOL_RS07200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SWOL_RS07215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SWOL_RS07265	COG1639	'signal transduction protein
SWOL_RS07275	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SWOL_RS07280	COG1187	pseudouridine synthase activity
SWOL_RS07285	COG0302	gtp cyclohydrolase
SWOL_RS07290	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SWOL_RS07305	COG0700	Nucleoside recognition
SWOL_RS07310	COG2715	membrane protein required for spore maturation
SWOL_RS07315	COG3874	Sporulation protein YtfJ
SWOL_RS07330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SWOL_RS07335	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SWOL_RS07340	COG1994	Peptidase M50
SWOL_RS07345	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SWOL_RS07345	COG3620	sequence-specific DNA binding
SWOL_RS07345	COG0617	tRNA 3'-terminal CCA addition
SWOL_RS07355	COG0019	diaminopimelate decarboxylase activity
SWOL_RS07365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SWOL_RS07370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SWOL_RS07380	COG1862	Preprotein translocase
SWOL_RS07385	COG0343	queuine tRNA-ribosyltransferase activity
SWOL_RS07390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SWOL_RS07395	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SWOL_RS07400	COG2255	four-way junction helicase activity
SWOL_RS07405	COG0632	four-way junction helicase activity
SWOL_RS07410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SWOL_RS07420	COG0217	transcriptional regulatory protein
SWOL_RS07430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SWOL_RS07435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SWOL_RS07455	COG1410	methionine synthase
SWOL_RS07455	COG0646	methionine synthase
SWOL_RS07460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SWOL_RS07470	COG0606	chelatase, subunit chli
SWOL_RS07475	COG1406	Chemotaxis phosphatase CheX
SWOL_RS07485	COG2201	protein-glutamate methylesterase activity
SWOL_RS07490	COG2201	protein-glutamate methylesterase activity
SWOL_RS07495	COG0835	chemotaxis
SWOL_RS07500	COG0840	transmembrane signaling receptor activity
SWOL_RS07505	COG0443	Heat shock 70 kDa protein
SWOL_RS07515	COG1192	Involved in chromosome partitioning
SWOL_RS07520	COG2198	Histidine kinase
SWOL_RS07520	COG0643	Histidine kinase
SWOL_RS07525	COG0745	RESPONSE REGULATOR receiver
SWOL_RS07530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SWOL_RS07605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SWOL_RS07630	COG1120	ATPase activity
SWOL_RS07635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SWOL_RS07640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SWOL_RS07645	COG0792	nuclease activity
SWOL_RS07660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SWOL_RS07675	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SWOL_RS07685	COG1960	acyl-CoA dehydrogenase activity
SWOL_RS07690	COG1024	Enoyl-CoA hydratase
SWOL_RS07695	COG1250	3-hydroxyacyl-CoA dehydrogenase
SWOL_RS07700	COG0183	Belongs to the thiolase family
SWOL_RS07705	COG3829	transcription factor binding
SWOL_RS07705	COG3290	protein histidine kinase activity
SWOL_RS07720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SWOL_RS07725	COG0335	large ribosomal subunit rRNA binding
SWOL_RS07730	COG4752	Belongs to the RNA methyltransferase TrmD family
SWOL_RS07735	COG0336	Belongs to the RNA methyltransferase TrmD family
SWOL_RS07740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SWOL_RS07745	COG1837	Belongs to the UPF0109 family
SWOL_RS07750	COG0228	four-way junction DNA binding
SWOL_RS07755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SWOL_RS07760	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SWOL_RS07765	COG1307	EDD domain protein, DegV family
SWOL_RS07785	COG1671	Belongs to the UPF0178 family
SWOL_RS07815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SWOL_RS07820	COG0358	DNA primase activity
SWOL_RS07840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SWOL_RS07840	COG0574	Belongs to the PEP-utilizing enzyme family
SWOL_RS07845	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SWOL_RS07850	COG0517	IMP dehydrogenase activity
SWOL_RS07855	COG0751	glycine-tRNA ligase activity
SWOL_RS07860	COG0752	glycyl-tRNA synthetase alpha subunit
SWOL_RS07875	COG1333	cytochrome c biogenesis protein
SWOL_RS07880	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SWOL_RS07890	COG0778	Nitroreductase
SWOL_RS07970	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SWOL_RS07975	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SWOL_RS08050	COG3842	ATPase activity
SWOL_RS08055	COG4149	molybdate abc transporter
SWOL_RS08060	COG0725	ABC transporter, periplasmic molybdate-binding protein
SWOL_RS08070	COG1381	Involved in DNA repair and RecF pathway recombination
SWOL_RS08080	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SWOL_RS08085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SWOL_RS08090	COG0295	cytidine deaminase activity
SWOL_RS08095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SWOL_RS08100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SWOL_RS08105	COG1480	7TM receptor with intracellular HD hydrolase
SWOL_RS08110	COG1702	phosphate starvation-inducible protein PhoH
SWOL_RS08140	COG0537	adenosine 5'-monophosphoramidase activity
SWOL_RS08145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SWOL_RS08150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SWOL_RS08155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SWOL_RS08160	COG2264	protein methyltransferase activity
SWOL_RS08165	COG0484	heat shock protein binding
SWOL_RS08170	COG0443	Heat shock 70 kDa protein
SWOL_RS08185	COG1420	regulation of RNA biosynthetic process
SWOL_RS08195	COG0481	GTPase activity
SWOL_RS08200	COG0728	peptidoglycan biosynthetic process
SWOL_RS08215	COG0268	Binds directly to 16S ribosomal RNA
SWOL_RS08225	COG2050	protein possibly involved in aromatic compounds catabolism
SWOL_RS08230	COG3263	regulation of cellular component size
SWOL_RS08235	COG0402	S-adenosylhomocysteine deaminase activity
SWOL_RS08245	COG0402	S-adenosylhomocysteine deaminase activity
SWOL_RS08250	COG0737	Belongs to the 5'-nucleotidase family
SWOL_RS08255	COG2333	competence protein COMEC
SWOL_RS08255	COG0658	competence protein
SWOL_RS08265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SWOL_RS08265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SWOL_RS08275	COG0495	leucyl-tRNA aminoacylation
SWOL_RS08285	COG0799	negative regulation of ribosome biogenesis
SWOL_RS08290	COG1713	HD superfamily hydrolase involved in NAD metabolism
SWOL_RS08295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SWOL_RS08305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SWOL_RS08315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SWOL_RS08320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SWOL_RS08325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SWOL_RS08335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SWOL_RS08340	COG2868	ribosomal protein
SWOL_RS08345	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SWOL_RS08350	COG1530	ribonuclease E activity
SWOL_RS08360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SWOL_RS08380	COG1131	(ABC) transporter
SWOL_RS08385	COG1725	Transcriptional regulator
SWOL_RS08390	COG2203	Gaf domain
SWOL_RS08390	COG3706	GGDEF domain
SWOL_RS08390	COG4251	negative regulation of phosphorylation
SWOL_RS08390	COG5001	Diguanylate cyclase
SWOL_RS08410	COG1979	alcohol dehydrogenase
SWOL_RS08415	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SWOL_RS08445	COG0772	Belongs to the SEDS family
SWOL_RS08450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SWOL_RS08455	COG2894	cell division
SWOL_RS08460	COG0850	regulation of cytokinetic process
SWOL_RS08465	COG0768	penicillin binding
SWOL_RS08480	COG1077	Cell shape determining protein MreB Mrl
SWOL_RS08485	COG2003	Belongs to the UPF0758 family
SWOL_RS08490	COG0424	maF-like protein
SWOL_RS08500	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SWOL_RS08505	COG0306	phosphate transporter
SWOL_RS08515	COG0285	dihydrofolate synthase activity
SWOL_RS08520	COG0525	valine-tRNA ligase activity
SWOL_RS08525	COG0688	phosphatidylethanolamine metabolic process
SWOL_RS08530	COG0653	protein targeting
SWOL_RS08535	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SWOL_RS08540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SWOL_RS08545	COG1067	ATP-dependent peptidase activity
SWOL_RS08545	COG0470	DNA polymerase III
SWOL_RS08555	COG0740	serine-type endopeptidase activity
SWOL_RS08560	COG0544	peptidyl-prolyl cis-trans isomerase activity
SWOL_RS08570	COG0330	HflC and HflK could
SWOL_RS08590	COG1376	ErfK ybiS ycfS ynhG family protein
SWOL_RS08615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SWOL_RS08620	COG1073	alpha beta
SWOL_RS08625	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SWOL_RS08635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SWOL_RS08640	COG1970	mechanosensitive ion channel activity
SWOL_RS08650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SWOL_RS08660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SWOL_RS08665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SWOL_RS08690	COG0745	RESPONSE REGULATOR receiver
SWOL_RS08700	COG1136	(ABC) transporter
SWOL_RS08700	COG0577	efflux transmembrane transporter activity
SWOL_RS08715	COG2813	Specifically methylates the guanine in position
SWOL_RS08720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SWOL_RS08735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SWOL_RS08750	COG0303	'Molybdopterin
SWOL_RS08755	COG1120	ATPase activity
SWOL_RS08760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SWOL_RS08775	COG2217	Heavy metal translocating P-type atpase
SWOL_RS08800	COG2414	aldehyde ferredoxin oxidoreductase
SWOL_RS08805	COG0437	4 iron, 4 sulfur cluster binding
SWOL_RS08815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SWOL_RS08835	COG2333	competence protein COMEC
SWOL_RS08835	COG0658	competence protein
SWOL_RS08840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SWOL_RS08845	COG3944	biosynthesis protein
SWOL_RS08860	COG1136	(ABC) transporter
SWOL_RS08870	COG2304	oxidoreductase activity
SWOL_RS08880	COG0714	Associated with various cellular activities
SWOL_RS08895	COG1131	(ABC) transporter
SWOL_RS08930	COG0419	ATPase involved in DNA repair
SWOL_RS08935	COG0420	3'-5' exonuclease activity
SWOL_RS08940	COG0793	Belongs to the peptidase S41A family
SWOL_RS08945	COG0024	Methionine aminopeptidase
SWOL_RS08955	COG0427	acetyl-CoA hydrolase
SWOL_RS08960	COG4176	ABC-type proline glycine betaine transport system permease component
SWOL_RS08965	COG0517	IMP dehydrogenase activity
SWOL_RS08965	COG4175	Glycine betaine
SWOL_RS08980	COG0765	amino acid transport
SWOL_RS09020	COG3266	domain, Protein
SWOL_RS09020	COG1361	Conserved repeat domain
SWOL_RS09020	COG2911	Protein conserved in bacteria
SWOL_RS09030	COG0427	acetyl-CoA hydrolase
SWOL_RS09055	COG1468	defense response to virus
SWOL_RS09055	COG1518	maintenance of DNA repeat elements
SWOL_RS09080	COG1337	RAMP superfamily
SWOL_RS09090	COG1353	crispr-associated protein
SWOL_RS09110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SWOL_RS09130	COG1253	flavin adenine dinucleotide binding
SWOL_RS09140	COG0107	imidazoleglycerol-phosphate synthase activity
SWOL_RS09145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SWOL_RS09150	COG0131	Imidazoleglycerol-phosphate dehydratase
SWOL_RS09160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SWOL_RS09165	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SWOL_RS09170	COG4496	protein, YerC YecD
SWOL_RS09185	COG0151	Belongs to the GarS family
SWOL_RS09190	COG0138	bifunctional purine biosynthesis protein purh
SWOL_RS09195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SWOL_RS09200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SWOL_RS09205	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SWOL_RS09215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SWOL_RS09230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SWOL_RS09230	COG0519	Catalyzes the synthesis of GMP from XMP
SWOL_RS09235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SWOL_RS09280	COG2208	phosphoserine phosphatase activity
SWOL_RS09280	COG2770	Histidine kinase
SWOL_RS09290	COG1366	Belongs to the anti-sigma-factor antagonist family
SWOL_RS09295	COG3642	lipopolysaccharide core region biosynthetic process
SWOL_RS09320	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SWOL_RS09325	COG1518	maintenance of DNA repeat elements
SWOL_RS09335	COG0556	nucleotide-excision repair
SWOL_RS09365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SWOL_RS09375	COG0617	tRNA 3'-terminal CCA addition
SWOL_RS09390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SWOL_RS09410	COG1910	domain protein
SWOL_RS09425	COG0437	4 iron, 4 sulfur cluster binding
SWOL_RS09430	COG3383	formate dehydrogenase (NAD+) activity
SWOL_RS09430	COG0243	molybdopterin cofactor binding
SWOL_RS09440	COG0303	'Molybdopterin
SWOL_RS09455	COG3383	formate dehydrogenase (NAD+) activity
SWOL_RS09465	COG0437	4 iron, 4 sulfur cluster binding
SWOL_RS09470	COG0446	pyridine nucleotide-disulphide oxidoreductase
SWOL_RS09510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SWOL_RS09515	COG0840	transmembrane signaling receptor activity
SWOL_RS09520	COG1960	acyl-CoA dehydrogenase activity
SWOL_RS09535	COG1408	metallophosphoesterase
SWOL_RS09540	COG0825	malonyl-CoA metabolic process
SWOL_RS09545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SWOL_RS09550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SWOL_RS09555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SWOL_RS09560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SWOL_RS09570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SWOL_RS09580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SWOL_RS09590	COG0459	protein refolding
SWOL_RS09595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SWOL_RS09600	COG0521	Mo-molybdopterin cofactor biosynthetic process
SWOL_RS09610	COG0315	cyclic pyranopterin monophosphate synthase activity
SWOL_RS09615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SWOL_RS09630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SWOL_RS09640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SWOL_RS09645	COG0456	acetyltransferase
SWOL_RS09650	COG1214	PFAM Peptidase M22, glycoprotease
SWOL_RS09655	COG0802	atpase or kinase
SWOL_RS09660	COG1573	uracil-dna glycosylase
SWOL_RS09700	COG2337	Toxic component of a toxin-antitoxin (TA) module
SWOL_RS09710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SWOL_RS09715	COG2337	Toxic component of a toxin-antitoxin (TA) module
SWOL_RS09720	COG0864	Transcriptional regulator
SWOL_RS09740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SWOL_RS09740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SWOL_RS09750	COG0835	chemotaxis
SWOL_RS09760	COG1376	ErfK ybiS ycfS ynhG family protein
SWOL_RS09765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SWOL_RS09770	COG1121	(ABC) transporter
SWOL_RS09775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
SWOL_RS09785	COG0398	Pfam SNARE associated Golgi protein
SWOL_RS09805	COG0513	Belongs to the DEAD box helicase family
SWOL_RS09815	COG0438	transferase activity, transferring glycosyl groups
SWOL_RS09820	COG1307	EDD domain protein, DegV family
SWOL_RS09825	COG0446	pyridine nucleotide-disulphide oxidoreductase
SWOL_RS09875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SWOL_RS09880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SWOL_RS09885	COG0662	Cupin 2, conserved barrel domain protein
SWOL_RS09885	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SWOL_RS09920	COG1164	Oligoendopeptidase f
SWOL_RS09925	COG1316	TRANSCRIPTIONal
SWOL_RS09930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SWOL_RS09940	COG1361	Conserved repeat domain
SWOL_RS09985	COG0427	acetyl-CoA hydrolase
SWOL_RS09990	COG1960	acyl-CoA dehydrogenase activity
SWOL_RS09995	COG0183	Belongs to the thiolase family
SWOL_RS10000	COG1250	3-hydroxyacyl-CoA dehydrogenase
SWOL_RS10005	COG1024	Enoyl-CoA hydratase
SWOL_RS10015	COG5002	protein histidine kinase activity
SWOL_RS10035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SWOL_RS10050	COG1924	4 iron, 4 sulfur cluster binding
SWOL_RS10060	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SWOL_RS10065	COG1122	ATPase activity
SWOL_RS10070	COG1122	ATPase activity
SWOL_RS10075	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SWOL_RS10080	COG1122	ATPase activity
SWOL_RS10085	COG1122	ATPase activity
SWOL_RS10105	COG1477	protein flavinylation
SWOL_RS10140	COG1361	Conserved repeat domain
SWOL_RS10140	COG3266	domain, Protein
SWOL_RS10140	COG2911	Protein conserved in bacteria
SWOL_RS10200	COG0095	Lipoate-protein ligase
SWOL_RS10215	COG3344	reverse transcriptase
SWOL_RS10225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SWOL_RS10230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SWOL_RS10235	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SWOL_RS10240	COG0509	glycine decarboxylation via glycine cleavage system
SWOL_RS10245	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SWOL_RS10300	COG2135	peptidase activity
SWOL_RS10305	COG0432	Pfam Uncharacterised protein family UPF0047
SWOL_RS10315	COG2172	sigma factor antagonist activity
SWOL_RS10390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SWOL_RS10410	COG0747	negative chemotaxis
SWOL_RS10415	COG0741	lytic transglycosylase activity
SWOL_RS10420	COG0237	dephospho-CoA kinase activity
SWOL_RS10425	COG1971	Probably functions as a manganese efflux pump
SWOL_RS10430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SWOL_RS10455	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SWOL_RS10460	COG3191	aminopeptidase activity
SWOL_RS10470	COG0463	Glycosyl transferase, family 2
SWOL_RS10470	COG0457	Tetratricopeptide repeat
SWOL_RS10495	COG1250	3-hydroxyacyl-CoA dehydrogenase
SWOL_RS10500	COG1024	Enoyl-CoA hydratase
SWOL_RS10515	COG1476	TRANSCRIPTIONal
SWOL_RS10525	COG3070	regulator of competence-specific genes
SWOL_RS10545	COG1131	(ABC) transporter
SWOL_RS10560	COG0205	6-phosphofructokinase activity
SWOL_RS10575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SWOL_RS10615	COG0183	Belongs to the thiolase family
SWOL_RS10620	COG1960	acyl-CoA dehydrogenase activity
SWOL_RS10625	COG3290	protein histidine kinase activity
SWOL_RS10625	COG3829	transcription factor binding
SWOL_RS10630	COG0426	domain, Protein
SWOL_RS10650	COG1595	DNA-templated transcription, initiation
SWOL_RS10680	COG1696	Membrane protein involved in D-alanine export
SWOL_RS10685	COG2197	response regulator
SWOL_RS10695	COG0464	growth
SWOL_RS10735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SWOL_RS10755	COG2801	Transposase and inactivated derivatives
SWOL_RS10770	COG0560	Phosphoserine phosphatase
SWOL_RS10780	COG0730	response to heat
SWOL_RS10790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SWOL_RS10800	COG0640	Transcriptional regulator
SWOL_RS10815	COG1342	Belongs to the UPF0251 family
SWOL_RS10830	COG0436	Aminotransferase
SWOL_RS10840	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SWOL_RS10865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SWOL_RS10870	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SWOL_RS10880	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SWOL_RS10905	COG2385	sporulation resulting in formation of a cellular spore
SWOL_RS10915	COG0411	ABC transporter
SWOL_RS10925	COG0559	Belongs to the binding-protein-dependent transport system permease family
SWOL_RS10940	COG0328	RNA-DNA hybrid ribonuclease activity
SWOL_RS10975	COG2086	electron transfer activity
SWOL_RS10980	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
SWOL_RS10985	COG0644	oxidoreductase
SWOL_RS10990	COG1960	acyl-CoA dehydrogenase activity
SWOL_RS10995	COG1846	Transcriptional regulator
SWOL_RS11000	COG0427	acetyl-CoA hydrolase
SWOL_RS11010	COG1024	Enoyl-CoA hydratase
SWOL_RS11020	COG0784	Response regulator, receiver
SWOL_RS11035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SWOL_RS11040	COG2081	HI0933 family
SWOL_RS11050	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SWOL_RS11060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SWOL_RS11065	COG0473	3-isopropylmalate dehydrogenase activity
SWOL_RS11070	COG0066	3-isopropylmalate dehydratase activity
SWOL_RS11075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SWOL_RS11080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SWOL_RS11085	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SWOL_RS11090	COG0440	acetolactate synthase activity
SWOL_RS11095	COG0028	Belongs to the TPP enzyme family
SWOL_RS11100	COG0129	dihydroxy-acid dehydratase activity
SWOL_RS11115	COG2770	Histidine kinase
SWOL_RS11115	COG3437	response regulator, receiver
SWOL_RS11120	COG0840	transmembrane signaling receptor activity
SWOL_RS11125	COG0840	transmembrane signaling receptor activity
SWOL_RS11150	COG0463	Glycosyl transferase, family 2
SWOL_RS11175	COG0840	transmembrane signaling receptor activity
SWOL_RS11185	COG0778	Nitroreductase
SWOL_RS11205	COG2703	oxygen carrier activity
SWOL_RS11240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SWOL_RS11250	COG0745	RESPONSE REGULATOR receiver
SWOL_RS11280	COG3266	domain, Protein
SWOL_RS11280	COG2911	Protein conserved in bacteria
SWOL_RS11280	COG1361	Conserved repeat domain
SWOL_RS11285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SWOL_RS11315	COG1151	hydroxylamine reductase activity
SWOL_RS11360	COG4695	Portal protein
SWOL_RS11375	COG3436	PFAM IS66 Orf2 family protein
SWOL_RS11380	COG4372	Transposase
SWOL_RS11425	COG3436	PFAM IS66 Orf2 family protein
SWOL_RS11430	COG4372	Transposase
SWOL_RS11455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SWOL_RS11515	COG1079	Belongs to the binding-protein-dependent transport system permease family
SWOL_RS11530	COG2274	protein secretion by the type I secretion system
SWOL_RS11555	COG1013	pyruvate-flavodoxin oxidoreductase activity
SWOL_RS11560	COG0674	pyruvate-flavodoxin oxidoreductase activity
SWOL_RS11590	COG0393	Putative heavy-metal-binding
SWOL_RS11600	COG1131	(ABC) transporter
SWOL_RS11605	COG1725	Transcriptional regulator
SWOL_RS11655	COG0582	viral genome integration into host DNA
SWOL_RS11665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SWOL_RS11675	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SWOL_RS11705	COG2003	Belongs to the UPF0758 family
SWOL_RS11710	COG5377	YqaJ viral recombinase family
SWOL_RS11730	COG4974	Belongs to the 'phage' integrase family
SWOL_RS11765	COG3394	polysaccharide catabolic process
SWOL_RS11820	COG4372	Transposase
SWOL_RS11855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SWOL_RS11860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SWOL_RS11865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SWOL_RS11870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SWOL_RS11875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SWOL_RS11890	COG2078	PFAM AMMECR1 domain protein
SWOL_RS11890	COG3885	ferrous iron binding
SWOL_RS11895	COG0860	N-Acetylmuramoyl-L-alanine amidase
SWOL_RS11905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SWOL_RS11910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SWOL_RS11915	COG0101	tRNA pseudouridine synthase activity
SWOL_RS11920	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SWOL_RS11925	COG1122	ATPase activity
SWOL_RS11930	COG1122	ATPase activity
SWOL_RS11935	COG0203	ribosomal protein L17
SWOL_RS11940	COG0202	RNA polymerase activity
SWOL_RS11945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SWOL_RS11950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SWOL_RS11955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SWOL_RS11960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SWOL_RS11965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SWOL_RS11980	COG0563	adenylate kinase activity
SWOL_RS11985	COG0201	protein transport
SWOL_RS11990	COG0200	Binds to the 23S rRNA
SWOL_RS11995	COG1841	ribosomal large subunit assembly
SWOL_RS12000	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SWOL_RS12005	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SWOL_RS12010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SWOL_RS12015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SWOL_RS12020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SWOL_RS12025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SWOL_RS12030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SWOL_RS12035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SWOL_RS12040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SWOL_RS12045	COG0255	Belongs to the universal ribosomal protein uL29 family
SWOL_RS12050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SWOL_RS12055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SWOL_RS12060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SWOL_RS12065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SWOL_RS12070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SWOL_RS12075	COG0089	rRNA binding
SWOL_RS12080	COG0088	Forms part of the polypeptide exit tunnel
SWOL_RS12085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SWOL_RS12090	COG0051	transcription antitermination factor activity, RNA binding
SWOL_RS12095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SWOL_RS12100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SWOL_RS12105	COG0049	tRNA binding
SWOL_RS12110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SWOL_RS12115	COG1358	cellular component organization or biogenesis
SWOL_RS12120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SWOL_RS12125	COG0085	RNA polymerase activity
SWOL_RS12135	COG0222	ribosome binding
SWOL_RS12140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SWOL_RS12145	COG0081	regulation of translation
SWOL_RS12150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SWOL_RS12155	COG0250	Participates in transcription elongation, termination and antitermination
SWOL_RS12165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SWOL_RS12170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SWOL_RS12205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SWOL_RS12210	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SWOL_RS12220	COG0215	cysteine-tRNA ligase activity
SWOL_RS12225	COG1045	serine acetyltransferase
SWOL_RS12230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SWOL_RS12235	COG4086	secreted protein
SWOL_RS12240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SWOL_RS12245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SWOL_RS12250	COG4956	integral membrane protein (PIN domain superfamily)
SWOL_RS12255	COG0426	domain, Protein
SWOL_RS12265	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SWOL_RS12270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SWOL_RS12275	COG0542	response to heat
SWOL_RS12280	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SWOL_RS12285	COG3880	PFAM UvrB UvrC protein
SWOL_RS12305	COG4786	Flagellar basal body rod
SWOL_RS12310	COG1077	Cell shape determining protein MreB Mrl
SWOL_RS12315	COG1609	Transcriptional regulator
SWOL_RS12320	COG2385	sporulation resulting in formation of a cellular spore
SWOL_RS12325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SWOL_RS12345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SWOL_RS12350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SWOL_RS12360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SWOL_RS12365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SWOL_RS12370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SWOL_RS12375	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SWOL_RS12380	COG0356	it plays a direct role in the translocation of protons across the membrane
SWOL_RS12400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SWOL_RS12405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SWOL_RS12410	COG1971	Probably functions as a manganese efflux pump
SWOL_RS12415	COG0009	L-threonylcarbamoyladenylate synthase
SWOL_RS12420	COG2890	protein-(glutamine-N5) methyltransferase activity
SWOL_RS12425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SWOL_RS12430	COG3872	metal-dependent enzyme
SWOL_RS12435	COG0254	rRNA binding
SWOL_RS12460	COG3481	metal-dependent phosphohydrolase, HD sub domain
SWOL_RS12475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SWOL_RS12480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SWOL_RS12485	COG1494	fructose-1,6-bisphosphatase
SWOL_RS12490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SWOL_RS12500	COG2204	response regulator
SWOL_RS12510	COG0616	signal peptide processing
SWOL_RS12515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SWOL_RS12525	COG0504	CTP synthase activity
SWOL_RS12530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SWOL_RS12540	COG0018	arginyl-trna synthetase
SWOL_RS12560	COG2210	Belongs to the sulfur carrier protein TusA family
SWOL_RS12590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SWOL_RS12595	COG2011	ABC-type metal ion transport system permease component
SWOL_RS12605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SWOL_RS12630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SWOL_RS12635	COG1216	Glycosyl transferase, family 2
SWOL_RS12655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SWOL_RS12675	COG1131	(ABC) transporter
SWOL_RS12680	COG1131	(ABC) transporter
SWOL_RS12685	COG0842	Transport permease protein
SWOL_RS12705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SWOL_RS12710	COG0528	UMP kinase activity
SWOL_RS12720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SWOL_RS12725	COG1136	(ABC) transporter
SWOL_RS12725	COG4591	ABC-type transport system involved in lipoprotein release permease component
SWOL_RS12730	COG0577	efflux transmembrane transporter activity
SWOL_RS12735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SWOL_RS12740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SWOL_RS12760	COG0393	Putative heavy-metal-binding
SWOL_RS12775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SWOL_RS12785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SWOL_RS12795	COG0492	ferredoxin-NADP+ reductase activity
SWOL_RS12825	COG1840	ABC-type Fe3 transport system, periplasmic component
SWOL_RS12835	COG3842	ATPase activity
SWOL_RS12840	COG1840	ABC-type Fe3 transport system, periplasmic component
SWOL_RS12850	COG3842	ATPase activity
SWOL_RS12875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SWOL_RS12930	COG3206	protein involved in exopolysaccharide biosynthesis
SWOL_RS12935	COG1506	peptidase
SWOL_RS12935	COG0823	Involved in the tonB-independent uptake of proteins
SWOL_RS12995	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SWOL_RS13000	COG1518	maintenance of DNA repeat elements
SWOL_RS13090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SWOL_RS13095	COG0470	DNA polymerase III
SWOL_RS13095	COG1067	ATP-dependent peptidase activity
SWOL_RS13100	COG0359	binds to the 23S rRNA
SWOL_RS13115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SWOL_RS13120	COG0629	single-stranded DNA binding
SWOL_RS13125	COG0360	Binds together with S18 to 16S ribosomal RNA
SWOL_RS13140	COG0709	Synthesizes selenophosphate from selenide and ATP
SWOL_RS13150	COG1362	aminopeptidase activity
SWOL_RS13160	COG0398	Pfam SNARE associated Golgi protein
SWOL_RS13170	COG2204	response regulator
SWOL_RS13190	COG0517	IMP dehydrogenase activity
SWOL_RS13210	COG0559	Belongs to the binding-protein-dependent transport system permease family
SWOL_RS13220	COG1924	4 iron, 4 sulfur cluster binding
SWOL_RS13245	COG3949	Membrane
SWOL_RS13260	COG0739	heme binding
SWOL_RS13265	COG1024	Enoyl-CoA hydratase
SWOL_RS13270	COG1475	DNA binding
SWOL_RS13275	COG1192	Involved in chromosome partitioning
SWOL_RS13285	COG0357	Ribosomal RNA small subunit methyltransferase G
SWOL_RS13290	COG0445	tRNA wobble uridine modification
SWOL_RS13295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SWOL_RS13300	COG1847	R3H domain protein
SWOL_RS13305	COG0706	membrane insertase activity
SWOL_RS13310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SWOL_RS13315	COG0594	ribonuclease P activity
SWOL_RS13320	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SWOL_RS13340	COG4467	Involved in initiation control of chromosome replication
SWOL_RS13350	COG1316	TRANSCRIPTIONal
SWOL_RS13355	COG0860	N-Acetylmuramoyl-L-alanine amidase
SWOL_RS13355	COG4991	sh3 domain protein
SWOL_RS13355	COG3103	Sh3 type 3 domain protein
SWOL_RS13355	COG4991	sh3 domain protein
SWOL_RS13355	COG3103	Sh3 type 3 domain protein
SWOL_RS13355	COG0860	N-Acetylmuramoyl-L-alanine amidase
SWOL_RS13360	COG1361	Conserved repeat domain
SWOL_RS13360	COG2911	Protein conserved in bacteria
SWOL_RS13360	COG3266	domain, Protein
SWOL_RS13380	COG1404	Belongs to the peptidase S8 family
SWOL_RS13385	COG0793	Belongs to the peptidase S41A family
SWOL_RS13430	COG0850	regulation of cytokinetic process
SWOL_RS13435	COG2198	Histidine kinase
SWOL_RS13435	COG0643	Histidine kinase
SWOL_RS13440	COG0840	transmembrane signaling receptor activity
SWOL_RS13490	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SWOL_RS13490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SWOL_RS13500	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SWOL_RS13515	COG4191	Histidine kinase
SWOL_RS13545	COG1388	LysM domain
SWOL_RS13545	COG0791	NLP P60 protein
SWOL_RS13565	COG1131	(ABC) transporter
SWOL_RS13585	COG2020	methyltransferase activity
SWOL_RS13605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SWOL_RS13630	COG2205	protein histidine kinase activity
SWOL_RS13655	COG2323	membrane
SWOL_RS13675	COG1215	transferase activity, transferring glycosyl groups
SWOL_RS13680	COG5002	protein histidine kinase activity
SWOL_RS13685	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SWOL_RS13690	COG3829	transcription factor binding
SWOL_RS13690	COG3290	protein histidine kinase activity
SWOL_RS13710	COG1361	Conserved repeat domain
SWOL_RS13720	COG1396	sequence-specific DNA binding
SWOL_RS13730	COG2208	phosphoserine phosphatase activity
SWOL_RS13740	COG0789	Transcriptional regulator
SWOL_RS13755	COG4251	negative regulation of phosphorylation
SWOL_RS13795	COG0739	heme binding
SWOL_RS13805	COG0745	RESPONSE REGULATOR receiver
SWOL_RS13810	COG1309	transcriptional regulator
SWOL_RS13815	COG0739	heme binding
SWOL_RS13845	COG5002	protein histidine kinase activity