locus-tag	class	description
A7E78_RS00010	COG0746	molybdenum cofactor guanylyltransferase activity
A7E78_RS00015	COG1763	Mo-molybdopterin cofactor biosynthetic process
A7E78_RS00025	COG0725	ABC transporter, periplasmic molybdate-binding protein
A7E78_RS00030	COG4149	molybdate abc transporter
A7E78_RS00035	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A7E78_RS00045	COG1410	methionine synthase
A7E78_RS00045	COG0646	methionine synthase
A7E78_RS00090	COG1454	alcohol dehydrogenase
A7E78_RS00090	COG1012	belongs to the aldehyde dehydrogenase family
A7E78_RS00100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A7E78_RS00100	COG0517	IMP dehydrogenase activity
A7E78_RS00155	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A7E78_RS00155	COG0778	Nitroreductase
A7E78_RS00185	COG0398	Pfam SNARE associated Golgi protein
A7E78_RS00190	COG2226	methyltransferase
A7E78_RS00195	COG0545	Peptidyl-prolyl cis-trans isomerase
A7E78_RS00205	COG0725	ABC transporter, periplasmic molybdate-binding protein
A7E78_RS00215	COG3842	ATPase activity
A7E78_RS00220	COG0725	ABC transporter, periplasmic molybdate-binding protein
A7E78_RS00225	COG1047	Peptidyl-prolyl cis-trans
A7E78_RS00230	COG1047	Peptidyl-prolyl cis-trans
A7E78_RS00245	COG4191	Histidine kinase
A7E78_RS00265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7E78_RS00280	COG0489	protein tyrosine kinase activity
A7E78_RS00290	COG3267	Type II secretory pathway component ExeA
A7E78_RS00290	COG3409	Peptidoglycan-binding domain 1 protein
A7E78_RS00300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7E78_RS00300	COG0463	Glycosyl transferase, family 2
A7E78_RS00335	COG0726	polysaccharide deacetylase
A7E78_RS00345	COG0438	transferase activity, transferring glycosyl groups
A7E78_RS00350	COG0438	transferase activity, transferring glycosyl groups
A7E78_RS00350	COG0297	glycogen (starch) synthase activity
A7E78_RS00390	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A7E78_RS00425	COG4191	Histidine kinase
A7E78_RS00435	COG2204	response regulator
A7E78_RS00445	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7E78_RS00455	COG0471	metal ion transport
A7E78_RS00460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7E78_RS00460	COG0116	Belongs to the methyltransferase superfamily
A7E78_RS00480	COG1971	Probably functions as a manganese efflux pump
A7E78_RS00490	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A7E78_RS00510	COG2840	Smr protein MutS2
A7E78_RS00515	COG1530	ribonuclease E activity
A7E78_RS00520	COG0488	(ABC) transporter
A7E78_RS00530	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A7E78_RS00550	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7E78_RS00560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A7E78_RS00570	COG1388	LysM domain
A7E78_RS00570	COG1376	ErfK ybiS ycfS ynhG family protein
A7E78_RS00575	COG0745	RESPONSE REGULATOR receiver
A7E78_RS00580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A7E78_RS00590	COG0105	UTP biosynthetic process
A7E78_RS00595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A7E78_RS00600	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A7E78_RS00615	COG2204	response regulator
A7E78_RS00620	COG0589	response to stress
A7E78_RS00625	COG4191	Histidine kinase
A7E78_RS00635	COG3481	metal-dependent phosphohydrolase, HD sub domain
A7E78_RS00640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7E78_RS00645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A7E78_RS00655	COG1573	uracil-dna glycosylase
A7E78_RS00665	COG0390	transport system, permease component
A7E78_RS00675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A7E78_RS00685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A7E78_RS00690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A7E78_RS00695	COG0193	aminoacyl-tRNA hydrolase activity
A7E78_RS00700	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A7E78_RS00705	COG0012	GTP binding
A7E78_RS00710	COG0360	Binds together with S18 to 16S ribosomal RNA
A7E78_RS00715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7E78_RS00725	COG0359	binds to the 23S rRNA
A7E78_RS00730	COG0305	Participates in initiation and elongation during chromosome replication
A7E78_RS00740	COG3852	Histidine kinase
A7E78_RS00780	COG3008	intermembrane lipid transfer
A7E78_RS00780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7E78_RS00785	COG2995	paraquat-inducible protein a
A7E78_RS00790	COG2995	paraquat-inducible protein a
A7E78_RS00820	COG1234	tRNA 3'-trailer cleavage
A7E78_RS00825	COG0840	transmembrane signaling receptor activity
A7E78_RS00835	COG0840	transmembrane signaling receptor activity
A7E78_RS00835	COG5278	phosphoserine phosphatase activity
A7E78_RS00850	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
A7E78_RS00855	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A7E78_RS00860	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A7E78_RS00870	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
A7E78_RS00880	COG1433	Dinitrogenase iron-molybdenum cofactor
A7E78_RS00880	COG0535	radical SAM domain protein
A7E78_RS00885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A7E78_RS00890	COG0725	ABC transporter, periplasmic molybdate-binding protein
A7E78_RS00895	COG4149	molybdate abc transporter
A7E78_RS00910	COG0577	efflux transmembrane transporter activity
A7E78_RS00910	COG1136	(ABC) transporter
A7E78_RS00915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7E78_RS00930	COG2951	lytic endotransglycosylase activity
A7E78_RS00945	COG0142	geranyltranstransferase activity
A7E78_RS00950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7E78_RS00955	COG0612	Peptidase, M16
A7E78_RS00960	COG0612	Peptidase, M16
A7E78_RS00965	COG1295	ribonuclease BN
A7E78_RS00970	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7E78_RS00980	COG5002	protein histidine kinase activity
A7E78_RS00990	COG0604	alcohol dehydrogenase
A7E78_RS00995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7E78_RS01000	COG3437	response regulator, receiver
A7E78_RS01005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7E78_RS01005	COG2205	protein histidine kinase activity
A7E78_RS01020	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A7E78_RS01025	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A7E78_RS01040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7E78_RS01045	COG3576	pyridoxamine 5-phosphate
A7E78_RS01055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7E78_RS01080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A7E78_RS01080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A7E78_RS01085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A7E78_RS01090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7E78_RS01105	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7E78_RS01115	COG0318	PFAM AMP-dependent synthetase and ligase
A7E78_RS01135	COG2204	response regulator
A7E78_RS01145	COG0330	HflC and HflK could
A7E78_RS01150	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A7E78_RS01170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7E78_RS01175	COG0785	Cytochrome C biogenesis protein
A7E78_RS01185	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A7E78_RS01195	COG1321	iron dependent repressor
A7E78_RS01210	COG4771	TonB-dependent receptor
A7E78_RS01220	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A7E78_RS01225	COG0504	CTP synthase activity
A7E78_RS01230	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A7E78_RS01240	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A7E78_RS01260	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A7E78_RS01270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7E78_RS01275	COG1660	Displays ATPase and GTPase activities
A7E78_RS01285	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7E78_RS01295	COG3716	PTS system mannose fructose sorbose family IID component
A7E78_RS01305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7E78_RS01310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7E78_RS01330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A7E78_RS01340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A7E78_RS01350	COG1136	(ABC) transporter
A7E78_RS01355	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7E78_RS01365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7E78_RS01370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7E78_RS01380	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7E78_RS01385	COG1132	(ABC) transporter
A7E78_RS01390	COG1519	Transferase
A7E78_RS01395	COG1663	tetraacyldisaccharide 4'-kinase activity
A7E78_RS01400	COG2835	tetraacyldisaccharide 4'-kinase activity
A7E78_RS01410	COG0859	PFAM glycosyl transferase family 9
A7E78_RS01420	COG0438	transferase activity, transferring glycosyl groups
A7E78_RS01455	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A7E78_RS01470	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A7E78_RS01500	COG0367	asparagine synthase
A7E78_RS01540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7E78_RS01610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7E78_RS01620	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A7E78_RS01620	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A7E78_RS01625	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7E78_RS01630	COG1561	YicC-like family, N-terminal region
A7E78_RS01635	COG0194	GDP metabolic process
A7E78_RS01640	COG1758	RNA polymerase activity
A7E78_RS01650	COG0251	oxidation-reduction process
A7E78_RS01655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7E78_RS01670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A7E78_RS01675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A7E78_RS01680	COG0456	acetyltransferase
A7E78_RS01685	COG0543	2 iron, 2 sulfur cluster binding
A7E78_RS01690	COG0167	dihydroorotate dehydrogenase activity
A7E78_RS01695	COG0617	tRNA 3'-terminal CCA addition
A7E78_RS01695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A7E78_RS01695	COG3620	sequence-specific DNA binding
A7E78_RS01700	COG1994	Peptidase M50
A7E78_RS01705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A7E78_RS01710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A7E78_RS01715	COG1187	pseudouridine synthase activity
A7E78_RS01725	COG3267	Type II secretory pathway component ExeA
A7E78_RS01725	COG3409	Peptidoglycan-binding domain 1 protein
A7E78_RS01730	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A7E78_RS01735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7E78_RS01740	COG1923	regulation of RNA biosynthetic process
A7E78_RS01760	COG2983	Belongs to the UPF0260 family
A7E78_RS01780	COG1472	Belongs to the glycosyl hydrolase 3 family
A7E78_RS01785	COG1278	Cold shock
A7E78_RS01790	COG0513	Belongs to the DEAD box helicase family
A7E78_RS01795	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A7E78_RS01800	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A7E78_RS01815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7E78_RS01820	COG3956	TIGRFAM MazG family protein
A7E78_RS01830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A7E78_RS01835	COG0416	fatty acid biosynthetic process
A7E78_RS01840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7E78_RS01845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A7E78_RS01850	COG1028	Short-chain dehydrogenase reductase Sdr
A7E78_RS01860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7E78_RS01865	COG0698	ribose 5-phosphate isomerase
A7E78_RS01870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7E78_RS01875	COG2131	deaminase
A7E78_RS01880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A7E78_RS01885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7E78_RS01885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7E78_RS01895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7E78_RS01895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7E78_RS01900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7E78_RS01905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7E78_RS01925	COG2873	o-acetylhomoserine
A7E78_RS01930	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A7E78_RS01935	COG0776	regulation of translation
A7E78_RS01940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7E78_RS01945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A7E78_RS01955	COG1335	isochorismatase
A7E78_RS02000	COG4681	YaeQ
A7E78_RS02010	COG0513	Belongs to the DEAD box helicase family
A7E78_RS02015	COG0659	secondary active sulfate transmembrane transporter activity
A7E78_RS02020	COG0589	response to stress
A7E78_RS02035	COG0488	(ABC) transporter
A7E78_RS02050	COG0024	Methionine aminopeptidase
A7E78_RS02060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A7E78_RS02085	COG0793	Belongs to the peptidase S41A family
A7E78_RS02120	COG1355	regulation of microtubule-based process
A7E78_RS02125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7E78_RS02140	COG0308	aminopeptidase N
A7E78_RS02155	COG0617	tRNA 3'-terminal CCA addition
A7E78_RS02175	COG2954	triphosphatase activity
A7E78_RS02185	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A7E78_RS02190	COG0248	Ppx GppA phosphatase
A7E78_RS02195	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A7E78_RS02200	COG0720	synthase
A7E78_RS02205	COG0602	queuosine metabolic process
A7E78_RS02215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A7E78_RS02220	COG0742	ribosomal rna small subunit methyltransferase
A7E78_RS02225	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A7E78_RS02230	COG5001	Diguanylate cyclase
A7E78_RS02230	COG2203	Gaf domain
A7E78_RS02230	COG4251	negative regulation of phosphorylation
A7E78_RS02230	COG3706	GGDEF domain
A7E78_RS02260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7E78_RS02275	COG1160	GTP binding
A7E78_RS02285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7E78_RS02305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A7E78_RS02310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7E78_RS02320	COG1406	Chemotaxis phosphatase CheX
A7E78_RS02365	COG0084	hydrolase, TatD family'
A7E78_RS02370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7E78_RS02370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7E78_RS02375	COG1774	PSP1 C-terminal conserved region
A7E78_RS02385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7E78_RS02390	COG0571	ribonuclease III activity
A7E78_RS02405	COG1160	GTP binding
A7E78_RS02415	COG0745	RESPONSE REGULATOR receiver
A7E78_RS02420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A7E78_RS02425	COG0495	leucyl-tRNA aminoacylation
A7E78_RS02440	COG0268	Binds directly to 16S ribosomal RNA
A7E78_RS02445	COG0728	peptidoglycan biosynthetic process
A7E78_RS02455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7E78_RS02460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A7E78_RS02465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7E78_RS02470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7E78_RS02475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A7E78_RS02480	COG0072	phenylalanine-tRNA ligase activity
A7E78_RS02485	COG0776	regulation of translation
A7E78_RS02490	COG0789	Transcriptional regulator
A7E78_RS02495	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A7E78_RS02500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A7E78_RS02505	COG1238	metal cluster binding
A7E78_RS02510	COG4942	peptidase
A7E78_RS02520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7E78_RS02530	COG0641	radical SAM
A7E78_RS02550	COG3119	arylsulfatase activity
A7E78_RS02595	COG0149	triose-phosphate isomerase activity
A7E78_RS02600	COG0126	phosphoglycerate kinase activity
A7E78_RS02610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7E78_RS02615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7E78_RS02620	COG0047	phosphoribosylformylglycinamidine synthase activity
A7E78_RS02625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A7E78_RS02630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A7E78_RS02640	COG1605	Chorismate mutase
A7E78_RS02640	COG0077	Prephenate dehydratase
A7E78_RS02650	COG0741	lytic transglycosylase activity
A7E78_RS02655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7E78_RS02690	COG0544	peptidyl-prolyl cis-trans isomerase activity
A7E78_RS02695	COG0740	serine-type endopeptidase activity
A7E78_RS02700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A7E78_RS02705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7E78_RS02710	COG0776	regulation of translation
A7E78_RS02730	COG2884	Cell division ATP-binding protein ftsE
A7E78_RS02735	COG2177	Part of the ABC transporter FtsEX involved in
A7E78_RS02740	COG4942	peptidase
A7E78_RS02755	COG1192	Involved in chromosome partitioning
A7E78_RS02760	COG1570	exodeoxyribonuclease VII activity
A7E78_RS02765	COG1722	exodeoxyribonuclease VII activity
A7E78_RS02775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A7E78_RS02780	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
A7E78_RS02785	COG0156	8-amino-7-oxononanoate synthase activity
A7E78_RS02790	COG2267	carboxylic ester hydrolase activity
A7E78_RS02795	COG2226	methyltransferase
A7E78_RS02805	COG0530	calcium, potassium:sodium antiporter activity
A7E78_RS02815	COG1227	inorganic diphosphatase activity
A7E78_RS02815	COG0517	IMP dehydrogenase activity
A7E78_RS02820	COG1331	Highly conserved protein containing a thioredoxin domain
A7E78_RS02830	COG0456	acetyltransferase
A7E78_RS02835	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7E78_RS02840	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7E78_RS02845	COG1151	hydroxylamine reductase activity
A7E78_RS02855	COG0326	Molecular chaperone. Has ATPase activity
A7E78_RS02870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7E78_RS02890	COG0318	PFAM AMP-dependent synthetase and ligase
A7E78_RS02910	COG0500	methyltransferase
A7E78_RS02995	COG0318	PFAM AMP-dependent synthetase and ligase
A7E78_RS03000	COG0481	GTPase activity
A7E78_RS03005	COG0681	Belongs to the peptidase S26 family
A7E78_RS03010	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A7E78_RS03015	COG0540	Belongs to the ATCase OTCase family
A7E78_RS03020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7E78_RS03025	COG0505	Belongs to the CarA family
A7E78_RS03030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A7E78_RS03035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7E78_RS03045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A7E78_RS03070	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A7E78_RS03085	COG1283	sodium-dependent phosphate transmembrane transporter activity
A7E78_RS03090	COG0009	L-threonylcarbamoyladenylate synthase
A7E78_RS03095	COG0756	dUTP diphosphatase activity
A7E78_RS03100	COG0612	Peptidase, M16
A7E78_RS03105	COG1185	polyribonucleotide nucleotidyltransferase activity
A7E78_RS03110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7E78_RS03115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A7E78_RS03120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A7E78_RS03125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A7E78_RS03135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A7E78_RS03145	COG0195	Participates in both transcription termination and antitermination
A7E78_RS03150	COG0779	Required for maturation of 30S ribosomal subunits
A7E78_RS03160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7E78_RS03165	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A7E78_RS03190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A7E78_RS03190	COG0674	pyruvate-flavodoxin oxidoreductase activity
A7E78_RS03215	COG3206	protein involved in exopolysaccharide biosynthesis
A7E78_RS03215	COG0489	protein tyrosine kinase activity
A7E78_RS03220	COG1596	polysaccharide export
A7E78_RS03240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7E78_RS03250	COG3021	interspecies interaction between organisms
A7E78_RS03270	COG1960	acyl-CoA dehydrogenase activity
A7E78_RS03280	COG2086	electron transfer activity
A7E78_RS03285	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A7E78_RS03315	COG0438	transferase activity, transferring glycosyl groups
A7E78_RS03365	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A7E78_RS03370	COG4974	Belongs to the 'phage' integrase family
A7E78_RS03390	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A7E78_RS03395	COG0205	6-phosphofructokinase activity
A7E78_RS03405	COG1940	carbohydrate kinase activity
A7E78_RS03410	COG0848	biopolymer transport protein
A7E78_RS03415	COG0811	peptide transport
A7E78_RS03440	COG0347	Belongs to the P(II) protein family
A7E78_RS03485	COG4964	Belongs to the GSP D family
A7E78_RS03535	COG0463	Glycosyl transferase, family 2
A7E78_RS03560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7E78_RS03590	COG1074	ATP-dependent DNA helicase activity
A7E78_RS03645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7E78_RS03655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7E78_RS03665	COG0058	SHG alpha-glucan phosphorylase activity
A7E78_RS03675	COG1178	ABC-type Fe3 transport system permease component
A7E78_RS03680	COG3842	ATPase activity
A7E78_RS03685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A7E78_RS03690	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A7E78_RS03690	COG3264	Mechanosensitive ion channel
A7E78_RS03700	COG4067	protein conserved in archaea
A7E78_RS03700	COG0189	ligase activity
A7E78_RS03705	COG0189	ligase activity
A7E78_RS03720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7E78_RS03730	COG2226	methyltransferase
A7E78_RS03740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7E78_RS03740	COG0116	Belongs to the methyltransferase superfamily
A7E78_RS03750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7E78_RS03755	COG2176	DNA-directed DNA polymerase activity
A7E78_RS03760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7E78_RS03770	COG0724	RNA recognition motif
A7E78_RS03805	COG2815	serine threonine protein kinase
A7E78_RS03805	COG0515	serine threonine protein kinase
A7E78_RS03820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A7E78_RS03865	COG0484	heat shock protein binding
A7E78_RS03890	COG4783	chaperone-mediated protein folding
A7E78_RS03940	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7E78_RS03950	COG5002	protein histidine kinase activity
A7E78_RS03960	COG0493	'glutamate synthase
A7E78_RS03965	COG0070	glutamate synthase
A7E78_RS03965	COG0069	glutamate synthase activity
A7E78_RS03965	COG0067	glutamate synthase
A7E78_RS04060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A7E78_RS04085	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
A7E78_RS04100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A7E78_RS04110	COG0402	S-adenosylhomocysteine deaminase activity
A7E78_RS04115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A7E78_RS04120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A7E78_RS04125	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A7E78_RS04135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A7E78_RS04145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7E78_RS04150	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A7E78_RS04155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7E78_RS04160	COG2983	Belongs to the UPF0260 family
A7E78_RS04165	COG2270	Major facilitator Superfamily
A7E78_RS04175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7E78_RS04180	COG0482	sulfurtransferase activity
A7E78_RS04185	COG0822	iron-sulfur transferase activity
A7E78_RS04190	COG1104	cysteine desulfurase activity
A7E78_RS04195	COG1959	2 iron, 2 sulfur cluster binding
A7E78_RS04200	COG1045	serine acetyltransferase
A7E78_RS04215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7E78_RS04225	COG0653	protein targeting
A7E78_RS04230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7E78_RS04245	COG0601	transmembrane transport
A7E78_RS04265	COG1366	Belongs to the anti-sigma-factor antagonist family
A7E78_RS04285	COG0564	pseudouridine synthase activity
A7E78_RS04295	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A7E78_RS04295	COG2050	protein possibly involved in aromatic compounds catabolism
A7E78_RS04300	COG0776	regulation of translation
A7E78_RS04305	COG0616	signal peptide processing
A7E78_RS04310	COG0539	negative regulation of cytoplasmic translation
A7E78_RS04315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A7E78_RS04320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A7E78_RS04325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A7E78_RS04335	COG1605	Chorismate mutase
A7E78_RS04335	COG0077	Prephenate dehydratase
A7E78_RS04340	COG0436	Aminotransferase
A7E78_RS04345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7E78_RS04350	COG1607	acyl-coa hydrolase
A7E78_RS04375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A7E78_RS04390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7E78_RS04410	COG1528	Iron-storage protein
A7E78_RS04430	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A7E78_RS04435	COG0640	Transcriptional regulator
A7E78_RS04440	COG4191	Histidine kinase
A7E78_RS04445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7E78_RS04475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7E78_RS04480	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A7E78_RS04490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7E78_RS04510	COG0785	Cytochrome C biogenesis protein
A7E78_RS04530	COG0789	Transcriptional regulator
A7E78_RS04540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7E78_RS04540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7E78_RS04545	COG0626	cystathionine gamma-synthase activity
A7E78_RS04550	COG0626	cystathionine gamma-synthase activity
A7E78_RS04590	COG0347	Belongs to the P(II) protein family
A7E78_RS04635	COG0482	sulfurtransferase activity
A7E78_RS04640	COG1104	cysteine desulfurase activity
A7E78_RS04655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7E78_RS04690	COG0347	Belongs to the P(II) protein family
A7E78_RS04770	COG2132	Multicopper oxidase
A7E78_RS04780	COG3634	alkyl hydroperoxide reductase activity
A7E78_RS04795	COG0653	protein targeting
A7E78_RS04810	COG0640	Transcriptional regulator
A7E78_RS04820	COG4453	Protein conserved in bacteria
A7E78_RS04845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A7E78_RS04880	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7E78_RS04885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7E78_RS04895	COG0343	queuine tRNA-ribosyltransferase activity
A7E78_RS04900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7E78_RS04910	COG1032	radical SAM domain protein
A7E78_RS04920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A7E78_RS04925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7E78_RS04930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7E78_RS04935	COG0101	tRNA pseudouridine synthase activity
A7E78_RS04945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A7E78_RS04950	COG0473	3-isopropylmalate dehydrogenase activity
A7E78_RS04960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7E78_RS04965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7E78_RS04970	COG1183	phosphatidylcholine synthase activity
A7E78_RS04975	COG0688	phosphatidylethanolamine metabolic process
A7E78_RS04980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A7E78_RS04985	COG0440	acetolactate synthase activity
A7E78_RS04990	COG0028	Belongs to the TPP enzyme family
A7E78_RS04995	COG0129	dihydroxy-acid dehydratase activity
A7E78_RS05005	COG1214	PFAM Peptidase M22, glycoprotease
A7E78_RS05010	COG0750	zinc metalloprotease
A7E78_RS05015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A7E78_RS05020	COG4589	Belongs to the CDS family
A7E78_RS05025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7E78_RS05030	COG0233	cytoplasmic translational termination
A7E78_RS05035	COG0528	UMP kinase activity
A7E78_RS05040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7E78_RS05045	COG0052	Belongs to the universal ribosomal protein uS2 family
A7E78_RS05060	COG4771	TonB-dependent receptor
A7E78_RS05075	COG4771	TonB-dependent receptor
A7E78_RS05080	COG0318	PFAM AMP-dependent synthetase and ligase
A7E78_RS05085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A7E78_RS05090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A7E78_RS05100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A7E78_RS05105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A7E78_RS05110	COG1480	7TM receptor with intracellular HD hydrolase
A7E78_RS05120	COG0148	phosphopyruvate hydratase activity
A7E78_RS05145	COG2848	UPF0210 protein
A7E78_RS05150	COG3830	Belongs to the UPF0237 family
A7E78_RS05170	COG2824	Alkylphosphonate utilization operon protein PhnA
A7E78_RS05185	COG4953	penicillin-binding protein 1C
A7E78_RS05190	COG2373	Large extracellular alpha-helical protein
A7E78_RS05195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7E78_RS05200	COG0343	queuine tRNA-ribosyltransferase activity
A7E78_RS05210	COG2201	protein-glutamate methylesterase activity
A7E78_RS05220	COG3706	GGDEF domain
A7E78_RS05225	COG1929	Belongs to the glycerate kinase type-1 family
A7E78_RS05235	COG0840	transmembrane signaling receptor activity
A7E78_RS05245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7E78_RS05250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7E78_RS05255	COG0825	malonyl-CoA metabolic process
A7E78_RS05260	COG0587	DNA-directed DNA polymerase activity
A7E78_RS05265	COG0424	maF-like protein
A7E78_RS05280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A7E78_RS05280	COG0519	Catalyzes the synthesis of GMP from XMP
A7E78_RS05285	COG0517	IMP dehydrogenase activity
A7E78_RS05285	COG0516	GMP reductase activity
A7E78_RS05290	COG1363	Peptidase, m42
A7E78_RS05295	COG0587	DNA-directed DNA polymerase activity
A7E78_RS05300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7E78_RS05315	COG1217	gtp-binding protein TYPA
A7E78_RS05320	COG3885	ferrous iron binding
A7E78_RS05320	COG2078	PFAM AMMECR1 domain protein
A7E78_RS05335	COG2204	response regulator
A7E78_RS05360	COG0745	RESPONSE REGULATOR receiver
A7E78_RS05370	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A7E78_RS05375	COG2201	protein-glutamate methylesterase activity
A7E78_RS05385	COG0643	Histidine kinase
A7E78_RS05385	COG2198	Histidine kinase
A7E78_RS05395	COG1815	bacterial-type flagellum-dependent cell motility
A7E78_RS05405	COG1677	Flagellar hook-basal body complex protein FliE
A7E78_RS05410	COG1766	The M ring may be actively involved in energy transduction
A7E78_RS05415	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A7E78_RS05425	COG1157	protein secretion by the type III secretion system
A7E78_RS05445	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A7E78_RS05460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A7E78_RS05465	COG1360	Flagellar Motor Protein
A7E78_RS05490	COG1338	Plays a role in the flagellum-specific transport system
A7E78_RS05495	COG1987	bacterial-type flagellum assembly
A7E78_RS05500	COG1684	flagellar biosynthetic protein fliR
A7E78_RS05505	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7E78_RS05510	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7E78_RS05515	COG1419	protein localization to endoplasmic reticulum
A7E78_RS05535	COG4786	Flagellar basal body rod
A7E78_RS05540	COG4786	Flagellar basal body rod
A7E78_RS05550	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A7E78_RS05555	COG1706	bacterial-type flagellum-dependent cell motility
A7E78_RS05575	COG4786	Flagellar basal body rod
A7E78_RS05580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A7E78_RS05585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7E78_RS05590	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A7E78_RS05600	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
A7E78_RS05605	COG2089	acid synthase
A7E78_RS05610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A7E78_RS05615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7E78_RS05620	COG1083	cytidylyl-transferase
A7E78_RS05630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A7E78_RS05635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7E78_RS05640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7E78_RS05660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A7E78_RS05665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A7E78_RS05675	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A7E78_RS05680	COG1516	flagellar protein fliS
A7E78_RS05710	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7E78_RS05730	COG2989	Protein conserved in bacteria
A7E78_RS05745	COG0442	prolyl-tRNA aminoacylation
A7E78_RS05750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A7E78_RS05755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7E78_RS05760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7E78_RS05770	COG2226	methyltransferase
A7E78_RS05790	COG0537	adenosine 5'-monophosphoramidase activity
A7E78_RS05810	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A7E78_RS05815	COG2208	phosphoserine phosphatase activity
A7E78_RS05830	COG0709	Synthesizes selenophosphate from selenide and ATP
A7E78_RS05850	COG1528	Iron-storage protein
A7E78_RS05870	COG0798	PFAM Bile acid sodium symporter
A7E78_RS05905	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A7E78_RS05915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A7E78_RS05920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7E78_RS05925	COG1077	Cell shape determining protein MreB Mrl
A7E78_RS05945	COG0772	Belongs to the SEDS family
A7E78_RS05955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A7E78_RS05960	COG2333	competence protein COMEC
A7E78_RS05960	COG0658	competence protein
A7E78_RS05970	COG0124	histidyl-tRNA synthetase
A7E78_RS05975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7E78_RS05985	COG0538	isocitrate dehydrogenase activity
A7E78_RS05990	COG0039	L-malate dehydrogenase activity
A7E78_RS06000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A7E78_RS06000	COG0674	pyruvate-flavodoxin oxidoreductase activity
A7E78_RS06005	COG1013	pyruvate-flavodoxin oxidoreductase activity
A7E78_RS06015	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A7E78_RS06045	COG0004	ammonium transporteR
A7E78_RS06050	COG0347	Belongs to the P(II) protein family
A7E78_RS06055	COG1067	ATP-dependent peptidase activity
A7E78_RS06060	COG0586	Pfam SNARE associated Golgi protein
A7E78_RS06065	COG2957	Belongs to the agmatine deiminase family
A7E78_RS06070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7E78_RS06080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7E78_RS06090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7E78_RS06095	COG0802	atpase or kinase
A7E78_RS06105	COG0736	holo-[acyl-carrier-protein] synthase activity
A7E78_RS06110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A7E78_RS06115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7E78_RS06125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A7E78_RS06130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A7E78_RS06135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7E78_RS06175	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A7E78_RS06180	COG3706	GGDEF domain
A7E78_RS06180	COG5001	Diguanylate cyclase
A7E78_RS06180	COG4251	negative regulation of phosphorylation
A7E78_RS06180	COG2203	Gaf domain
A7E78_RS06185	COG5002	protein histidine kinase activity
A7E78_RS06190	COG2197	response regulator
A7E78_RS06195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7E78_RS06195	COG1648	precorrin-2 dehydrogenase activity
A7E78_RS06210	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A7E78_RS06215	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A7E78_RS06225	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A7E78_RS06230	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A7E78_RS06235	COG1797	cobyrinic acid a,c-diamide synthase activity
A7E78_RS06270	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
A7E78_RS06310	COG4303	Ethanolamine ammonia lyase large subunit
A7E78_RS06320	COG1120	ATPase activity
A7E78_RS06330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7E78_RS06335	COG0714	Associated with various cellular activities
A7E78_RS06390	COG1454	alcohol dehydrogenase
A7E78_RS06390	COG1012	belongs to the aldehyde dehydrogenase family
A7E78_RS06395	COG0427	acetyl-CoA hydrolase
A7E78_RS06400	COG2197	response regulator
A7E78_RS06405	COG5002	protein histidine kinase activity
A7E78_RS06410	COG1584	GPR1 FUN34 yaaH family protein
A7E78_RS06445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A7E78_RS06450	COG1882	Formate acetyltransferase
A7E78_RS06460	COG5002	protein histidine kinase activity
A7E78_RS06465	COG2197	response regulator
A7E78_RS06475	COG0183	Belongs to the thiolase family
A7E78_RS06490	COG1748	Saccharopine dehydrogenase
A7E78_RS06515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7E78_RS06520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7E78_RS06530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A7E78_RS06535	COG0840	transmembrane signaling receptor activity
A7E78_RS06540	COG0477	Major facilitator Superfamily
A7E78_RS06570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7E78_RS06575	COG0577	efflux transmembrane transporter activity
A7E78_RS06575	COG1136	(ABC) transporter
A7E78_RS06580	COG1136	(ABC) transporter
A7E78_RS06580	COG0577	efflux transmembrane transporter activity
A7E78_RS06585	COG4191	Histidine kinase
A7E78_RS06600	COG0038	chloride channel
A7E78_RS06605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7E78_RS06610	COG0745	RESPONSE REGULATOR receiver
A7E78_RS06620	COG2205	protein histidine kinase activity
A7E78_RS06625	COG0745	RESPONSE REGULATOR receiver
A7E78_RS06635	COG3706	GGDEF domain
A7E78_RS06660	COG3842	ATPase activity
A7E78_RS06670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A7E78_RS06675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7E78_RS06680	COG0363	glucosamine-6-phosphate deaminase activity
A7E78_RS06690	COG0444	Belongs to the ABC transporter superfamily
A7E78_RS06695	COG4608	Belongs to the ABC transporter superfamily
A7E78_RS06700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7E78_RS06710	COG0525	valine-tRNA ligase activity
A7E78_RS06730	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A7E78_RS06735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A7E78_RS06740	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A7E78_RS06745	COG0653	protein targeting
A7E78_RS06750	COG0739	heme binding
A7E78_RS06755	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A7E78_RS06765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A7E78_RS06770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A7E78_RS06780	COG3437	response regulator, receiver
A7E78_RS06780	COG0784	Response regulator, receiver
A7E78_RS06785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A7E78_RS06795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A7E78_RS06800	COG1921	L-seryl-tRNASec selenium transferase activity
A7E78_RS06805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A7E78_RS06810	COG0573	inorganic phosphate transmembrane transporter activity
A7E78_RS06820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7E78_RS06840	COG0583	DNA-binding transcription factor activity
A7E78_RS06870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A7E78_RS06870	COG4451	ribulose bisphosphate carboxylase, small
A7E78_RS06875	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A7E78_RS06880	COG0746	molybdenum cofactor guanylyltransferase activity
A7E78_RS06885	COG2081	HI0933 family
A7E78_RS06890	COG1671	Belongs to the UPF0178 family
A7E78_RS06895	COG1368	sulfuric ester hydrolase activity
A7E78_RS06905	COG5002	protein histidine kinase activity
A7E78_RS06935	COG3174	membrane
A7E78_RS06995	COG4191	Histidine kinase
A7E78_RS07015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A7E78_RS07055	COG4191	Histidine kinase
A7E78_RS07065	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A7E78_RS07075	COG0584	glycerophosphoryl diester phosphodiesterase
A7E78_RS07080	COG1494	fructose-1,6-bisphosphatase
A7E78_RS07085	COG0217	transcriptional regulatory protein
A7E78_RS07090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A7E78_RS07095	COG0632	four-way junction helicase activity
A7E78_RS07100	COG2255	four-way junction helicase activity
A7E78_RS07110	COG1752	Esterase of the alpha-beta hydrolase superfamily
A7E78_RS07125	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A7E78_RS07130	COG5000	phosphorelay sensor kinase activity
A7E78_RS07135	COG2204	response regulator
A7E78_RS07140	COG0667	Aldo Keto reductase
A7E78_RS07145	COG1979	alcohol dehydrogenase
A7E78_RS07180	COG2207	Transcriptional regulator
A7E78_RS07200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A7E78_RS07205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A7E78_RS07210	COG0535	radical SAM domain protein
A7E78_RS07220	COG5002	protein histidine kinase activity
A7E78_RS07225	COG0745	RESPONSE REGULATOR receiver
A7E78_RS07230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7E78_RS07235	COG0745	RESPONSE REGULATOR receiver
A7E78_RS07240	COG5002	protein histidine kinase activity
A7E78_RS07250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7E78_RS07255	COG1408	metallophosphoesterase
A7E78_RS07260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A7E78_RS07270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A7E78_RS07275	COG0585	pseudouridine synthase activity
A7E78_RS07290	COG0237	dephospho-CoA kinase activity
A7E78_RS07300	COG3437	response regulator, receiver
A7E78_RS07300	COG2770	Histidine kinase
A7E78_RS07310	COG0543	2 iron, 2 sulfur cluster binding
A7E78_RS07315	COG0493	'glutamate synthase
A7E78_RS07335	COG0489	protein tyrosine kinase activity
A7E78_RS07360	COG0791	NLP P60 protein
A7E78_RS07385	COG0018	arginyl-trna synthetase
A7E78_RS07390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A7E78_RS07395	COG1596	polysaccharide export
A7E78_RS07395	COG1555	photosystem II stabilization
A7E78_RS07400	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A7E78_RS07410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A7E78_RS07415	COG0159	tryptophan synthase activity
A7E78_RS07420	COG1573	uracil-dna glycosylase
A7E78_RS07425	COG0513	Belongs to the DEAD box helicase family
A7E78_RS07430	COG0133	tryptophan synthase activity
A7E78_RS07435	COG0135	phosphoribosylanthranilate isomerase activity
A7E78_RS07440	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A7E78_RS07445	COG0134	indole-3-glycerol-phosphate synthase activity
A7E78_RS07450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7E78_RS07455	COG0512	Glutamine amidotransferase of anthranilate synthase
A7E78_RS07460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7E78_RS07465	COG0203	ribosomal protein L17
A7E78_RS07470	COG0202	RNA polymerase activity
A7E78_RS07475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A7E78_RS07480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A7E78_RS07485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A7E78_RS07490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7E78_RS07495	COG0024	Methionine aminopeptidase
A7E78_RS07500	COG0563	adenylate kinase activity
A7E78_RS07505	COG0201	protein transport
A7E78_RS07510	COG0200	Binds to the 23S rRNA
A7E78_RS07515	COG1841	ribosomal large subunit assembly
A7E78_RS07520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A7E78_RS07525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7E78_RS07530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7E78_RS07535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7E78_RS07540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7E78_RS07545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7E78_RS07550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A7E78_RS07555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A7E78_RS07560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A7E78_RS07565	COG0255	Belongs to the universal ribosomal protein uL29 family
A7E78_RS07570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7E78_RS07575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A7E78_RS07580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7E78_RS07585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A7E78_RS07590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A7E78_RS07595	COG0089	rRNA binding
A7E78_RS07600	COG0088	Forms part of the polypeptide exit tunnel
A7E78_RS07605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7E78_RS07610	COG0051	transcription antitermination factor activity, RNA binding
A7E78_RS07615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7E78_RS07620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7E78_RS07625	COG0049	tRNA binding
A7E78_RS07630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A7E78_RS07635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A7E78_RS07640	COG0085	RNA polymerase activity
A7E78_RS07645	COG0222	ribosome binding
A7E78_RS07650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7E78_RS07655	COG0081	regulation of translation
A7E78_RS07660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A7E78_RS07680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7E78_RS07685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7E78_RS07710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7E78_RS07715	COG0284	orotidine-5'-phosphate decarboxylase activity
A7E78_RS07725	COG0442	prolyl-tRNA aminoacylation
A7E78_RS07735	COG0436	Aminotransferase
A7E78_RS07745	COG0543	2 iron, 2 sulfur cluster binding
A7E78_RS07760	COG0121	glutamine amidotransferase
A7E78_RS07790	COG0037	tRNA processing
A7E78_RS07800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7E78_RS07810	COG1309	transcriptional regulator
A7E78_RS07840	COG0704	Plays a role in the regulation of phosphate uptake
A7E78_RS07845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7E78_RS07855	COG0573	inorganic phosphate transmembrane transporter activity
A7E78_RS07865	COG5002	protein histidine kinase activity
A7E78_RS07880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A7E78_RS07885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A7E78_RS07890	COG0330	HflC and HflK could
A7E78_RS07900	COG1674	ftsk spoiiie
A7E78_RS07905	COG1968	undecaprenyl-diphosphatase activity
A7E78_RS07910	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A7E78_RS07920	COG0629	single-stranded DNA binding
A7E78_RS07930	COG0528	UMP kinase activity
A7E78_RS07935	COG1509	lysine 2,3-aminomutase activity
A7E78_RS07960	COG0191	fructose-bisphosphate aldolase activity
A7E78_RS07970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A7E78_RS07975	COG0116	Belongs to the methyltransferase superfamily
A7E78_RS07990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A7E78_RS08000	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A7E78_RS08010	COG0330	HflC and HflK could
A7E78_RS08035	COG0840	transmembrane signaling receptor activity
A7E78_RS08050	COG2204	response regulator
A7E78_RS08055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7E78_RS08055	COG4191	Histidine kinase
A7E78_RS08075	COG3300	MHYT domain
A7E78_RS08075	COG5001	Diguanylate cyclase
A7E78_RS08080	COG0784	Response regulator, receiver
A7E78_RS08130	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A7E78_RS08140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A7E78_RS08145	COG0799	negative regulation of ribosome biogenesis
A7E78_RS08150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A7E78_RS08155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A7E78_RS08160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A7E78_RS08165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A7E78_RS08170	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7E78_RS08175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A7E78_RS08180	COG1530	ribonuclease E activity
A7E78_RS08190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A7E78_RS08200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7E78_RS08205	COG0004	ammonium transporteR
A7E78_RS08215	COG0069	glutamate synthase activity
A7E78_RS08220	COG0493	'glutamate synthase
A7E78_RS08220	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7E78_RS08240	COG1162	GTPase activity
A7E78_RS08255	COG0314	molybdopterin synthase activity
A7E78_RS08290	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A7E78_RS08305	COG0358	DNA primase activity
A7E78_RS08310	COG1193	negative regulation of DNA recombination
A7E78_RS08320	COG1610	YqeY-like protein
A7E78_RS08330	COG0107	imidazoleglycerol-phosphate synthase activity
A7E78_RS08335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A7E78_RS08340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A7E78_RS08345	COG0131	Imidazoleglycerol-phosphate dehydratase
A7E78_RS08350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A7E78_RS08355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A7E78_RS08360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A7E78_RS08365	COG2890	protein-(glutamine-N5) methyltransferase activity
A7E78_RS08370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7E78_RS08375	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A7E78_RS08380	COG0254	rRNA binding
A7E78_RS08385	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A7E78_RS08400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7E78_RS08405	COG1959	2 iron, 2 sulfur cluster binding
A7E78_RS08410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7E78_RS08415	COG0493	'glutamate synthase
A7E78_RS08425	COG2816	NAD+ diphosphatase activity
A7E78_RS08430	COG1597	lipid kinase activity
A7E78_RS08430	COG1803	Methylglyoxal synthase
A7E78_RS08445	COG0826	peptidase U32
A7E78_RS08450	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A7E78_RS08460	COG0758	DNA mediated transformation
A7E78_RS08465	COG2922	Belongs to the Smg family
A7E78_RS08470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7E78_RS08475	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A7E78_RS08485	COG0424	maF-like protein
A7E78_RS08490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A7E78_RS08495	COG0733	neurotransmitter:sodium symporter activity
A7E78_RS08500	COG0546	phosphoglycolate phosphatase activity
A7E78_RS08525	COG0668	transmembrane transport
A7E78_RS08530	COG0471	metal ion transport
A7E78_RS08540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A7E78_RS08605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7E78_RS08615	COG3409	Peptidoglycan-binding domain 1 protein
A7E78_RS08615	COG3267	Type II secretory pathway component ExeA
A7E78_RS08645	COG3108	Peptidase M15
A7E78_RS08650	COG1100	Small GTP-binding protein
A7E78_RS08660	COG0674	pyruvate-flavodoxin oxidoreductase activity
A7E78_RS08660	COG1013	pyruvate-flavodoxin oxidoreductase activity
A7E78_RS08660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A7E78_RS08660	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A7E78_RS08665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7E78_RS08670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7E78_RS08675	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7E78_RS08700	COG0735	belongs to the Fur family
A7E78_RS08705	COG1592	Rubrerythrin
A7E78_RS08710	COG1773	rubredoxin
A7E78_RS08715	COG0426	domain, Protein
A7E78_RS08725	COG2104	thiamine diphosphate biosynthetic process
A7E78_RS08730	COG2022	thiamine diphosphate biosynthetic process
A7E78_RS08735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7E78_RS08740	COG0352	thiamine-phosphate diphosphorylase activity
A7E78_RS08745	COG3273	potassium ion transport
A7E78_RS08745	COG0471	metal ion transport
A7E78_RS08750	COG0321	lipoyl(octanoyl) transferase activity
A7E78_RS08770	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7E78_RS08775	COG1515	deoxyribonuclease V activity
A7E78_RS08785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7E78_RS08785	COG0574	Belongs to the PEP-utilizing enzyme family
A7E78_RS08790	COG0751	glycine-tRNA ligase activity
A7E78_RS08795	COG0752	glycyl-tRNA synthetase alpha subunit
A7E78_RS08800	COG1381	Involved in DNA repair and RecF pathway recombination
A7E78_RS08805	COG2239	Acts as a magnesium transporter
A7E78_RS08820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7E78_RS08820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7E78_RS08890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7E78_RS08910	COG0017	Asparaginyl-tRNA synthetase
A7E78_RS08920	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A7E78_RS08925	COG4771	TonB-dependent receptor
A7E78_RS08950	COG1739	Uncharacterized protein family UPF0029
A7E78_RS08985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7E78_RS08995	COG3706	GGDEF domain
A7E78_RS08995	COG4251	negative regulation of phosphorylation
A7E78_RS08995	COG2203	Gaf domain
A7E78_RS08995	COG5001	Diguanylate cyclase
A7E78_RS09000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A7E78_RS09000	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A7E78_RS09005	COG1294	oxidase, subunit
A7E78_RS09010	COG1271	oxidase subunit
A7E78_RS09015	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A7E78_RS09015	COG0778	Nitroreductase
A7E78_RS09020	COG1280	lysine exporter protein (LysE YggA)
A7E78_RS09025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7E78_RS09030	COG3123	guanosine phosphorylase activity
A7E78_RS09055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A7E78_RS09060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A7E78_RS09065	COG0084	hydrolase, TatD family'
A7E78_RS09070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A7E78_RS09100	COG1522	sequence-specific DNA binding
A7E78_RS09110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7E78_RS09115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7E78_RS09125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A7E78_RS09130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A7E78_RS09140	COG0356	it plays a direct role in the translocation of protons across the membrane
A7E78_RS09165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7E78_RS09180	COG0469	pyruvate kinase activity
A7E78_RS09185	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A7E78_RS09190	COG1469	GTP cyclohydrolase I activity
A7E78_RS09220	COG0823	Involved in the tonB-independent uptake of proteins
A7E78_RS09225	COG2885	chlorophyll binding
A7E78_RS09235	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A7E78_RS09270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7E78_RS09275	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A7E78_RS09285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A7E78_RS09290	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A7E78_RS09295	COG0438	transferase activity, transferring glycosyl groups
A7E78_RS09310	COG0784	Response regulator, receiver
A7E78_RS09310	COG0835	chemotaxis
A7E78_RS09340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7E78_RS09365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7E78_RS09370	COG0321	lipoyl(octanoyl) transferase activity
A7E78_RS09370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7E78_RS09375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A7E78_RS09380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7E78_RS09385	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A7E78_RS09390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A7E78_RS09405	COG0328	RNA-DNA hybrid ribonuclease activity
A7E78_RS09410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7E78_RS09415	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7E78_RS09415	COG0649	NAD binding
A7E78_RS09420	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A7E78_RS09425	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A7E78_RS09430	COG1034	ATP synthesis coupled electron transport
A7E78_RS09435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A7E78_RS09440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7E78_RS09450	COG0713	ATP synthesis coupled electron transport
A7E78_RS09465	COG1007	ATP synthesis coupled electron transport
A7E78_RS09515	COG0493	'glutamate synthase
A7E78_RS09525	COG2226	methyltransferase
A7E78_RS09545	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A7E78_RS09550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7E78_RS09560	COG0725	ABC transporter, periplasmic molybdate-binding protein
A7E78_RS09565	COG4149	molybdate abc transporter
A7E78_RS09570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A7E78_RS09585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7E78_RS09590	COG0725	ABC transporter, periplasmic molybdate-binding protein
A7E78_RS09600	COG3706	GGDEF domain
A7E78_RS09610	COG4520	surface antigen
A7E78_RS09615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7E78_RS09640	COG0628	permease
A7E78_RS09650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A7E78_RS09660	COG5002	protein histidine kinase activity
A7E78_RS09665	COG0745	RESPONSE REGULATOR receiver
A7E78_RS09685	COG1012	belongs to the aldehyde dehydrogenase family
A7E78_RS09685	COG1454	alcohol dehydrogenase
A7E78_RS09690	COG3852	Histidine kinase
A7E78_RS09695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A7E78_RS09705	COG0315	cyclic pyranopterin monophosphate synthase activity
A7E78_RS09710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A7E78_RS09715	COG0277	FAD linked oxidase domain protein
A7E78_RS09730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A7E78_RS09740	COG0488	(ABC) transporter
A7E78_RS09775	COG1192	Involved in chromosome partitioning
A7E78_RS09790	COG4520	surface antigen
A7E78_RS09820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A7E78_RS09840	COG2259	Doxx family
A7E78_RS09845	COG5001	Diguanylate cyclase
A7E78_RS09850	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A7E78_RS09870	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7E78_RS09875	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7E78_RS09880	COG0310	cobalt ion transport
A7E78_RS09885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7E78_RS09930	COG0778	Nitroreductase
A7E78_RS09940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A7E78_RS09965	COG0455	bacterial-type flagellum organization
A7E78_RS09970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7E78_RS09990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A7E78_RS10005	COG3012	SEC-C Motif Domain Protein
A7E78_RS10020	COG2081	HI0933 family
A7E78_RS10030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7E78_RS10045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7E78_RS10045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7E78_RS10050	COG4807	Protein conserved in bacteria
A7E78_RS10075	COG0023	Translation Initiation Factor
A7E78_RS10090	COG1733	regulation of RNA biosynthetic process
A7E78_RS10100	COG0583	DNA-binding transcription factor activity
A7E78_RS10135	COG0500	methyltransferase
A7E78_RS10140	COG4106	trans-aconitate 2-methyltransferase activity
A7E78_RS10155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7E78_RS10165	COG1592	Rubrerythrin
A7E78_RS10170	COG0569	domain protein
A7E78_RS10175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A7E78_RS10180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A7E78_RS10185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A7E78_RS10195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7E78_RS10205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A7E78_RS10210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7E78_RS10215	COG0805	protein transport
A7E78_RS10220	COG4251	negative regulation of phosphorylation
A7E78_RS10220	COG5001	Diguanylate cyclase
A7E78_RS10220	COG3706	GGDEF domain
A7E78_RS10220	COG2203	Gaf domain
A7E78_RS10225	COG1131	(ABC) transporter
A7E78_RS10230	COG0842	Transport permease protein
A7E78_RS10240	COG1785	Belongs to the alkaline phosphatase family
A7E78_RS10265	COG4452	Inner membrane protein CreD
A7E78_RS10280	COG0556	nucleotide-excision repair
A7E78_RS10285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7E78_RS10290	COG1199	ATP-dependent helicase activity
A7E78_RS10300	COG0822	iron-sulfur transferase activity
A7E78_RS10305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7E78_RS10325	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A7E78_RS10330	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7E78_RS10335	COG0356	it plays a direct role in the translocation of protons across the membrane
A7E78_RS10350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A7E78_RS10355	COG0436	Aminotransferase
A7E78_RS10375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7E78_RS10390	COG0187	DNA topoisomerase II activity
A7E78_RS10395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A7E78_RS10405	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7E78_RS10410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A7E78_RS10415	COG0594	ribonuclease P activity
A7E78_RS10420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A7E78_RS10425	COG0706	membrane insertase activity
A7E78_RS10430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A7E78_RS10435	COG0445	tRNA wobble uridine modification
A7E78_RS10440	COG0357	Ribosomal RNA small subunit methyltransferase G
A7E78_RS10445	COG1192	Involved in chromosome partitioning
A7E78_RS10450	COG1475	DNA binding
A7E78_RS10460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A7E78_RS10470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7E78_RS10475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A7E78_RS10480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A7E78_RS10485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A7E78_RS10490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A7E78_RS10495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A7E78_RS10515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7E78_RS10520	COG1595	DNA-templated transcription, initiation
A7E78_RS10560	COG1278	Cold shock
A7E78_RS10570	COG0606	chelatase, subunit chli
A7E78_RS10575	COG0492	ferredoxin-NADP+ reductase activity
A7E78_RS10585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7E78_RS10590	COG1863	multisubunit Na H antiporter MnhE subunit
A7E78_RS10600	COG1320	monovalent cation:proton antiporter activity
A7E78_RS10615	COG1006	Multisubunit Na H antiporter MnhC subunit
A7E78_RS10620	COG0651	ATP synthesis coupled electron transport
A7E78_RS10625	COG0651	ATP synthesis coupled electron transport
A7E78_RS10635	COG0651	ATP synthesis coupled electron transport
A7E78_RS10640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7E78_RS10645	COG1420	regulation of RNA biosynthetic process
A7E78_RS10655	COG0443	Heat shock 70 kDa protein
A7E78_RS10660	COG0484	heat shock protein binding
A7E78_RS10675	COG0667	Aldo Keto reductase
A7E78_RS10685	COG2239	Acts as a magnesium transporter
A7E78_RS10690	COG1752	Esterase of the alpha-beta hydrolase superfamily
A7E78_RS10695	COG2003	Belongs to the UPF0758 family
A7E78_RS10700	COG0826	peptidase U32
A7E78_RS10720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A7E78_RS10725	COG1329	Transcriptional regulator
A7E78_RS10730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A7E78_RS10735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A7E78_RS10740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7E78_RS10745	COG0215	cysteine-tRNA ligase activity
A7E78_RS10755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7E78_RS10765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7E78_RS10770	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A7E78_RS10780	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A7E78_RS10785	COG1666	GTP binding
A7E78_RS10790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7E78_RS10795	COG1132	(ABC) transporter
A7E78_RS10800	COG1132	(ABC) transporter
A7E78_RS10810	COG2204	response regulator
A7E78_RS10825	COG1115	amino acid carrier protein
A7E78_RS10870	COG0438	transferase activity, transferring glycosyl groups
A7E78_RS10880	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A7E78_RS10885	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A7E78_RS10890	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A7E78_RS10895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A7E78_RS10900	COG4399	Belongs to the UPF0754 family
A7E78_RS10910	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7E78_RS10910	COG1136	(ABC) transporter
A7E78_RS10915	COG0577	efflux transmembrane transporter activity
A7E78_RS10915	COG1136	(ABC) transporter
A7E78_RS10920	COG0577	efflux transmembrane transporter activity
A7E78_RS10920	COG1136	(ABC) transporter
A7E78_RS10930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A7E78_RS10935	COG2204	response regulator
A7E78_RS10950	COG0303	'Molybdopterin
A7E78_RS10960	COG1454	alcohol dehydrogenase
A7E78_RS10965	COG1454	alcohol dehydrogenase
A7E78_RS10970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7E78_RS10975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A7E78_RS10990	COG0045	succinate-CoA ligase (ADP-forming) activity
A7E78_RS10995	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A7E78_RS11000	COG0242	peptide deformylase activity
A7E78_RS11015	COG0501	Belongs to the peptidase M48B family
A7E78_RS11020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7E78_RS11020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7E78_RS11025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A7E78_RS11030	COG0494	nUDIX hydrolase
A7E78_RS11035	COG0646	methionine synthase
A7E78_RS11035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A7E78_RS11040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A7E78_RS11050	COG1012	belongs to the aldehyde dehydrogenase family
A7E78_RS11050	COG1454	alcohol dehydrogenase
A7E78_RS11060	COG0484	heat shock protein binding
A7E78_RS11065	COG1763	Mo-molybdopterin cofactor biosynthetic process
A7E78_RS11090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A7E78_RS11125	COG0420	3'-5' exonuclease activity
A7E78_RS11130	COG0419	ATPase involved in DNA repair
A7E78_RS11260	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A7E78_RS11270	COG0646	methionine synthase
A7E78_RS11270	COG1410	methionine synthase
A7E78_RS11280	COG3959	Transketolase, thiamine diphosphate binding domain
A7E78_RS11285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A7E78_RS11290	COG2204	response regulator
A7E78_RS11295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7E78_RS11305	COG0668	transmembrane transport
A7E78_RS11315	COG0598	Magnesium transport protein CorA
A7E78_RS11325	COG0745	RESPONSE REGULATOR receiver
A7E78_RS11345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7E78_RS11370	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7E78_RS11400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7E78_RS11410	COG0488	(ABC) transporter
A7E78_RS11415	COG0564	pseudouridine synthase activity
A7E78_RS11440	COG1309	transcriptional regulator
A7E78_RS11445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7E78_RS11465	COG0730	response to heat
A7E78_RS11470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A7E78_RS11485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A7E78_RS11490	COG0004	ammonium transporteR
A7E78_RS11500	COG1053	succinate dehydrogenase
A7E78_RS11510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7E78_RS11525	COG2853	Lipoprotein
A7E78_RS11585	COG0714	Associated with various cellular activities
A7E78_RS11600	COG1120	ATPase activity
A7E78_RS11610	COG4302	ethanolamine ammonia-lyase activity
A7E78_RS11635	COG2205	protein histidine kinase activity
A7E78_RS11645	COG2204	response regulator
A7E78_RS11660	COG4191	Histidine kinase
A7E78_RS11665	COG2204	response regulator
A7E78_RS11670	COG2223	nitrite transmembrane transporter activity
A7E78_RS11685	COG1584	GPR1 FUN34 yaaH family protein
A7E78_RS11700	COG0840	transmembrane signaling receptor activity
A7E78_RS11705	COG2176	DNA-directed DNA polymerase activity
A7E78_RS11705	COG5002	protein histidine kinase activity
A7E78_RS11720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7E78_RS11730	COG0322	excinuclease ABC activity
A7E78_RS11795	COG0701	Predicted permease
A7E78_RS11810	COG0071	Belongs to the small heat shock protein (HSP20) family
A7E78_RS11815	COG0542	response to heat
A7E78_RS11820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7E78_RS11840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7E78_RS11845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7E78_RS11870	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A7E78_RS11880	COG0038	chloride channel
A7E78_RS11930	COG3064	Membrane
A7E78_RS11935	COG3239	Fatty acid desaturase
A7E78_RS11945	COG0778	Nitroreductase
A7E78_RS11955	COG1509	lysine 2,3-aminomutase activity
A7E78_RS11960	COG4716	Myosin-crossreactive antigen
A7E78_RS11965	COG1301	dicarboxylic acid transport
A7E78_RS11980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7E78_RS12005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A7E78_RS12010	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A7E78_RS12030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A7E78_RS12035	COG0163	prenyltransferase activity
A7E78_RS12040	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A7E78_RS12045	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A7E78_RS12050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7E78_RS12060	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A7E78_RS12065	COG0114	fumarate hydratase activity
A7E78_RS12075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A7E78_RS12105	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A7E78_RS12115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7E78_RS12120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A7E78_RS12125	COG0459	protein refolding
A7E78_RS12155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7E78_RS12155	COG2169	Transcriptional regulator
A7E78_RS12160	COG1119	ATPase activity
A7E78_RS12165	COG0612	Peptidase, M16
A7E78_RS12175	COG0113	porphobilinogen synthase activity
A7E78_RS12185	COG0181	hydroxymethylbilane synthase activity
A7E78_RS12190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A7E78_RS12195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7E78_RS12200	COG1648	precorrin-2 dehydrogenase activity
A7E78_RS12200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7E78_RS12205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A7E78_RS12210	COG3118	belongs to the thioredoxin family
A7E78_RS12215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7E78_RS12220	COG3028	Belongs to the UPF0307 family
A7E78_RS12225	COG1490	D-aminoacyl-tRNA deacylase activity
A7E78_RS12230	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A7E78_RS12255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7E78_RS12260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7E78_RS12270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A7E78_RS12275	COG2264	protein methyltransferase activity
A7E78_RS12280	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A7E78_RS12290	COG5002	protein histidine kinase activity
A7E78_RS12290	COG3850	Histidine kinase
A7E78_RS12295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7E78_RS12300	COG1234	tRNA 3'-trailer cleavage
A7E78_RS12310	COG2197	response regulator
A7E78_RS12315	COG1139	Iron-sulfur cluster binding protein
A7E78_RS12320	COG1139	Iron-sulfur cluster binding protein
A7E78_RS12335	COG0175	sulfate reduction
A7E78_RS12340	COG0175	sulfate reduction
A7E78_RS12350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7E78_RS12355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7E78_RS12360	COG1121	(ABC) transporter
A7E78_RS12380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A7E78_RS12405	COG1950	PFAM Membrane protein of
A7E78_RS12425	COG1242	4 iron, 4 sulfur cluster binding
A7E78_RS12460	COG0492	ferredoxin-NADP+ reductase activity
A7E78_RS12465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A7E78_RS12470	COG0069	glutamate synthase activity
A7E78_RS12470	COG0067	glutamate synthase
A7E78_RS12470	COG0070	glutamate synthase
A7E78_RS12475	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A7E78_RS12480	COG1396	sequence-specific DNA binding
A7E78_RS12500	COG0564	pseudouridine synthase activity
A7E78_RS12505	COG1496	oxidoreductase activity
A7E78_RS12515	COG2154	pterin-4-alpha-carbinolamine dehydratase
A7E78_RS12545	COG2357	RelA SpoT domain protein
A7E78_RS12555	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A7E78_RS12560	COG0640	Transcriptional regulator
A7E78_RS12580	COG0297	glycogen (starch) synthase activity
A7E78_RS12600	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A7E78_RS12605	COG2204	response regulator
A7E78_RS12610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7E78_RS12620	COG2205	protein histidine kinase activity
A7E78_RS12640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A7E78_RS12645	COG1278	Cold shock
A7E78_RS12650	COG1104	cysteine desulfurase activity
A7E78_RS12660	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A7E78_RS12675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7E78_RS12695	COG1872	DUF167
A7E78_RS12710	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7E78_RS12715	COG0432	Pfam Uncharacterised protein family UPF0047
A7E78_RS12725	COG4974	Belongs to the 'phage' integrase family
A7E78_RS12750	COG0427	acetyl-CoA hydrolase
A7E78_RS12760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7E78_RS12770	COG0514	ATP-dependent DNA helicase (RecQ)
A7E78_RS12775	COG0708	Exodeoxyribonuclease III
A7E78_RS12805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7E78_RS12810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A7E78_RS12815	COG0166	Belongs to the GPI family
A7E78_RS12820	COG3852	Histidine kinase
A7E78_RS12825	COG4191	Histidine kinase
A7E78_RS12825	COG0784	Response regulator, receiver
A7E78_RS12835	COG2204	response regulator
A7E78_RS12845	COG0835	chemotaxis
A7E78_RS12850	COG0840	transmembrane signaling receptor activity
A7E78_RS12855	COG1720	tRNA m6t6A37 methyltransferase activity
A7E78_RS12860	COG5002	protein histidine kinase activity
A7E78_RS12890	COG0564	pseudouridine synthase activity
A7E78_RS12895	COG1196	nuclear chromosome segregation
A7E78_RS12905	COG0552	protein localization to endoplasmic reticulum
A7E78_RS12920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7E78_RS12925	COG1418	mRNA catabolic process
A7E78_RS12930	COG1692	metallophosphoesterase
A7E78_RS12935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A7E78_RS13015	COG2033	superoxide reductase activity
A7E78_RS13020	COG1592	Rubrerythrin
A7E78_RS13030	COG1151	hydroxylamine reductase activity
A7E78_RS13080	COG1902	pentaerythritol trinitrate reductase activity
A7E78_RS13080	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7E78_RS13100	COG2234	aminopeptidase activity
A7E78_RS13105	COG0840	transmembrane signaling receptor activity
A7E78_RS13110	COG2264	protein methyltransferase activity
A7E78_RS13115	COG3152	Membrane
A7E78_RS13135	COG0393	Putative heavy-metal-binding
A7E78_RS13140	COG1253	flavin adenine dinucleotide binding
A7E78_RS13150	COG0697	spore germination
A7E78_RS13190	COG0438	transferase activity, transferring glycosyl groups
A7E78_RS13195	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A7E78_RS13200	COG0671	phosphoesterase, PA-phosphatase related
A7E78_RS13210	COG3830	Belongs to the UPF0237 family
A7E78_RS13210	COG0560	Phosphoserine phosphatase
A7E78_RS13215	COG1489	DNA binding
A7E78_RS13220	COG1323	Belongs to the UPF0348 family
A7E78_RS13245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7E78_RS13300	COG0437	4 iron, 4 sulfur cluster binding
A7E78_RS13320	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A7E78_RS13335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7E78_RS13345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7E78_RS13350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7E78_RS13355	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7E78_RS13370	COG0280	phosphate acetyltransferase
A7E78_RS13380	COG0509	glycine decarboxylation via glycine cleavage system
A7E78_RS13405	COG0295	cytidine deaminase activity
A7E78_RS13410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7E78_RS13415	COG0242	peptide deformylase activity
A7E78_RS13425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7E78_RS13430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7E78_RS13435	COG0109	protoheme IX farnesyltransferase activity
A7E78_RS13470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7E78_RS13485	COG1509	lysine 2,3-aminomutase activity
A7E78_RS13505	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A7E78_RS13510	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A7E78_RS13515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7E78_RS13520	COG0778	Nitroreductase
A7E78_RS13530	COG1408	metallophosphoesterase
A7E78_RS13560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7E78_RS13575	COG0583	DNA-binding transcription factor activity
A7E78_RS13610	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7E78_RS13620	COG0436	Aminotransferase
A7E78_RS13630	COG0668	transmembrane transport
A7E78_RS13635	COG2814	Major facilitator Superfamily
A7E78_RS13645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A7E78_RS13650	COG5002	protein histidine kinase activity
A7E78_RS13665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A7E78_RS13670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7E78_RS13690	COG0668	transmembrane transport
A7E78_RS13695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7E78_RS13705	COG3706	GGDEF domain
A7E78_RS13710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7E78_RS13715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7E78_RS13720	COG2205	protein histidine kinase activity
A7E78_RS13725	COG0745	RESPONSE REGULATOR receiver
A7E78_RS13730	COG4869	propanediol catabolic process
A7E78_RS13735	COG3005	denitrification pathway
A7E78_RS13740	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A7E78_RS13760	COG3864	Putative metallopeptidase domain
A7E78_RS13780	COG0488	(ABC) transporter
A7E78_RS13785	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A7E78_RS13795	COG0426	domain, Protein
A7E78_RS13795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7E78_RS13820	COG0484	heat shock protein binding
A7E78_RS13835	COG1012	belongs to the aldehyde dehydrogenase family
A7E78_RS13845	COG0277	FAD linked oxidase domain protein
A7E78_RS13870	COG1073	alpha beta
A7E78_RS13880	COG1525	nuclease
A7E78_RS13890	COG1606	tRNA processing
A7E78_RS13895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7E78_RS13900	COG0436	Aminotransferase
A7E78_RS13905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7E78_RS13910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7E78_RS13915	COG0019	diaminopimelate decarboxylase activity
A7E78_RS13925	COG0165	Argininosuccinate lyase
A7E78_RS13930	COG0137	argininosuccinate synthase activity
A7E78_RS13935	COG1714	RDD family
A7E78_RS13945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7E78_RS13950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7E78_RS13955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7E78_RS13960	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A7E78_RS13965	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A7E78_RS13980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7E78_RS13985	COG2137	regulation of response to DNA damage stimulus
A7E78_RS13995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A7E78_RS14005	COG1058	Belongs to the CinA family
A7E78_RS14005	COG1546	Belongs to the CinA family
A7E78_RS14010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A7E78_RS14025	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A7E78_RS14030	COG1691	(AIR) carboxylase
A7E78_RS14040	COG1122	ATPase activity
A7E78_RS14070	COG0811	peptide transport
A7E78_RS14075	COG0848	biopolymer transport protein
A7E78_RS14090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7E78_RS14095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7E78_RS14115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A7E78_RS14120	COG0352	thiamine-phosphate diphosphorylase activity
A7E78_RS14120	COG0351	phosphomethylpyrimidine kinase
A7E78_RS14125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A7E78_RS14135	COG0138	bifunctional purine biosynthesis protein purh
A7E78_RS14145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A7E78_RS14150	COG1333	cytochrome c biogenesis protein
A7E78_RS14155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7E78_RS14160	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A7E78_RS14170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7E78_RS14175	COG0228	four-way junction DNA binding
A7E78_RS14180	COG1837	Belongs to the UPF0109 family
A7E78_RS14185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A7E78_RS14190	COG0336	Belongs to the RNA methyltransferase TrmD family
A7E78_RS14195	COG4752	Belongs to the RNA methyltransferase TrmD family
A7E78_RS14200	COG0335	large ribosomal subunit rRNA binding
A7E78_RS14205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A7E78_RS14215	COG3706	GGDEF domain
A7E78_RS14240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7E78_RS14255	COG0803	Belongs to the bacterial solute-binding protein 9 family
A7E78_RS14260	COG0792	nuclease activity
A7E78_RS14270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A7E78_RS14275	COG1254	Belongs to the acylphosphatase family
A7E78_RS14280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7E78_RS14285	COG4536	flavin adenine dinucleotide binding
A7E78_RS14290	COG2001	Belongs to the MraZ family
A7E78_RS14295	COG0275	rRNA processing
A7E78_RS14300	COG3116	cell division
A7E78_RS14310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7E78_RS14315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7E78_RS14320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7E78_RS14325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A7E78_RS14330	COG0772	Belongs to the SEDS family
A7E78_RS14335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7E78_RS14340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7E78_RS14345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A7E78_RS14350	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7E78_RS14355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A7E78_RS14365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A7E78_RS14375	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A7E78_RS14400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7E78_RS14405	COG0281	malic enzyme
A7E78_RS14435	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A7E78_RS14440	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A7E78_RS14445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7E78_RS14450	COG0154	amidase activity
A7E78_RS14455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7E78_RS14500	COG3852	Histidine kinase
A7E78_RS14505	COG2204	response regulator
A7E78_RS14515	COG4966	pilus assembly protein PilW
A7E78_RS14545	COG0557	exoribonuclease II activity
A7E78_RS14550	COG0196	riboflavin kinase activity
A7E78_RS14555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7E78_RS14560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7E78_RS14570	COG1459	type II secretion system
A7E78_RS14575	COG3852	Histidine kinase
A7E78_RS14580	COG2204	response regulator
A7E78_RS14590	COG1131	(ABC) transporter
A7E78_RS14635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A7E78_RS14640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A7E78_RS14645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A7E78_RS14660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7E78_RS14665	COG0006	proline dipeptidase activity
A7E78_RS14670	COG0511	ligase activity, forming carbon-carbon bonds
A7E78_RS14675	COG0439	Biotin carboxylase
A7E78_RS14685	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A7E78_RS14695	COG0582	viral genome integration into host DNA
A7E78_RS14735	COG1053	succinate dehydrogenase
A7E78_RS14740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7E78_RS14775	COG2861	carbohydrate metabolic process
A7E78_RS14810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7E78_RS14825	COG0140	phosphoribosyl-ATP diphosphatase activity
A7E78_RS14835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7E78_RS14845	COG0729	surface antigen
A7E78_RS15030	COG0183	Belongs to the thiolase family
A7E78_RS15085	COG1309	transcriptional regulator
A7E78_RS15135	COG1410	methionine synthase
A7E78_RS15135	COG0646	methionine synthase
A7E78_RS15145	COG1410	methionine synthase
A7E78_RS15145	COG0646	methionine synthase
A7E78_RS15150	COG5001	Diguanylate cyclase
A7E78_RS15150	COG4251	negative regulation of phosphorylation
A7E78_RS15150	COG3706	GGDEF domain
A7E78_RS15150	COG2203	Gaf domain
A7E78_RS15210	COG2111	Na H antiporter
A7E78_RS15230	COG0840	transmembrane signaling receptor activity
A7E78_RS15240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family