locus-tag	class	description
SLIP_RS00010	COG0592	DNA-directed DNA polymerase activity
SLIP_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SLIP_RS00025	COG0187	DNA topoisomerase II activity
SLIP_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SLIP_RS00035	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SLIP_RS00040	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SLIP_RS00050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SLIP_RS00055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SLIP_RS00080	COG0590	tRNA wobble adenosine to inosine editing
SLIP_RS00105	COG0784	Response regulator, receiver
SLIP_RS00105	COG3437	response regulator, receiver
SLIP_RS00110	COG2703	oxygen carrier activity
SLIP_RS00155	COG0463	Glycosyl transferase, family 2
SLIP_RS00155	COG0457	Tetratricopeptide repeat
SLIP_RS00195	COG2391	methyltransferase activity
SLIP_RS00200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SLIP_RS00205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SLIP_RS00210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SLIP_RS00270	COG1982	Orn Lys Arg decarboxylase major
SLIP_RS00275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLIP_RS00290	COG1774	PSP1 C-terminal conserved region
SLIP_RS00300	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SLIP_RS00305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SLIP_RS00310	COG2002	toxin-antitoxin pair type II binding
SLIP_RS00315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLIP_RS00315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLIP_RS00320	COG0084	hydrolase, TatD family'
SLIP_RS00325	COG3583	domain protein
SLIP_RS00325	COG3584	3D domain protein
SLIP_RS00335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SLIP_RS00340	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
SLIP_RS00345	COG4466	Protein conserved in bacteria
SLIP_RS00365	COG1752	Esterase of the alpha-beta hydrolase superfamily
SLIP_RS00375	COG3481	metal-dependent phosphohydrolase, HD sub domain
SLIP_RS00385	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
SLIP_RS00410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SLIP_RS00470	COG1136	(ABC) transporter
SLIP_RS00470	COG4591	ABC-type transport system involved in lipoprotein release permease component
SLIP_RS00475	COG0577	efflux transmembrane transporter activity
SLIP_RS00475	COG1136	(ABC) transporter
SLIP_RS00495	COG5002	protein histidine kinase activity
SLIP_RS00500	COG0745	RESPONSE REGULATOR receiver
SLIP_RS00515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SLIP_RS00520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SLIP_RS00530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SLIP_RS00535	COG1802	Transcriptional regulator
SLIP_RS00545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SLIP_RS00550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SLIP_RS00555	COG0193	aminoacyl-tRNA hydrolase activity
SLIP_RS00560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SLIP_RS00565	COG2002	toxin-antitoxin pair type II binding
SLIP_RS00570	COG2244	polysaccharide biosynthetic process
SLIP_RS00575	COG3956	TIGRFAM MazG family protein
SLIP_RS00580	COG0776	regulation of translation
SLIP_RS00585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SLIP_RS00610	COG1098	S1 RNA binding domain
SLIP_RS00615	COG0248	Ppx GppA phosphatase
SLIP_RS00625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SLIP_RS00650	COG2208	phosphoserine phosphatase activity
SLIP_RS00655	COG0037	tRNA processing
SLIP_RS00665	COG0105	UTP biosynthetic process
SLIP_RS00670	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SLIP_RS00675	COG1418	mRNA catabolic process
SLIP_RS00680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SLIP_RS00685	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SLIP_RS00690	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SLIP_RS00695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SLIP_RS00700	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SLIP_RS00705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SLIP_RS00710	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SLIP_RS00715	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SLIP_RS00720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SLIP_RS00735	COG3191	aminopeptidase activity
SLIP_RS00740	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SLIP_RS00745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SLIP_RS00765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SLIP_RS00770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SLIP_RS00775	COG0445	tRNA wobble uridine modification
SLIP_RS00800	COG1598	PFAM Uncharacterised protein family UPF0150
SLIP_RS00805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SLIP_RS00810	COG1316	TRANSCRIPTIONal
SLIP_RS00840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SLIP_RS00870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SLIP_RS00875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SLIP_RS00885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SLIP_RS00940	COG0330	HflC and HflK could
SLIP_RS00980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SLIP_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
SLIP_RS01015	COG0728	peptidoglycan biosynthetic process
SLIP_RS01050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SLIP_RS01055	COG1333	cytochrome c biogenesis protein
SLIP_RS01060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SLIP_RS01070	COG1122	ATPase activity
SLIP_RS01075	COG1122	ATPase activity
SLIP_RS01080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SLIP_RS01090	COG3976	FMN-binding domain protein
SLIP_RS01090	COG1053	succinate dehydrogenase
SLIP_RS01100	COG0577	efflux transmembrane transporter activity
SLIP_RS01105	COG1136	(ABC) transporter
SLIP_RS01110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SLIP_RS01125	COG0656	L-ascorbic acid biosynthetic process
SLIP_RS01130	COG1979	alcohol dehydrogenase
SLIP_RS01140	COG1309	transcriptional regulator
SLIP_RS01150	COG1131	(ABC) transporter
SLIP_RS01155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SLIP_RS01160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SLIP_RS01170	COG1592	Rubrerythrin
SLIP_RS01175	COG0351	phosphomethylpyrimidine kinase
SLIP_RS01175	COG0352	thiamine-phosphate diphosphorylase activity
SLIP_RS01180	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SLIP_RS01185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SLIP_RS01200	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLIP_RS01205	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLIP_RS01210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLIP_RS01215	COG0649	NAD binding
SLIP_RS01220	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SLIP_RS01230	COG0839	Belongs to the complex I subunit 6 family
SLIP_RS01240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SLIP_RS01245	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLIP_RS01250	COG1007	ATP synthesis coupled electron transport
SLIP_RS01260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SLIP_RS01270	COG0668	transmembrane transport
SLIP_RS01280	COG1459	type II secretion system
SLIP_RS01310	COG3266	domain, Protein
SLIP_RS01310	COG2911	Protein conserved in bacteria
SLIP_RS01310	COG1361	Conserved repeat domain
SLIP_RS01335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SLIP_RS01350	COG0483	inositol monophosphate 1-phosphatase activity
SLIP_RS01360	COG2814	Major facilitator Superfamily
SLIP_RS01365	COG3829	transcription factor binding
SLIP_RS01365	COG3290	protein histidine kinase activity
SLIP_RS01370	COG0183	Belongs to the thiolase family
SLIP_RS01375	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLIP_RS01380	COG1960	acyl-CoA dehydrogenase activity
SLIP_RS01385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SLIP_RS01390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SLIP_RS01405	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SLIP_RS01445	COG0697	spore germination
SLIP_RS01480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SLIP_RS01485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SLIP_RS01495	COG1959	2 iron, 2 sulfur cluster binding
SLIP_RS01500	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SLIP_RS01510	COG0544	peptidyl-prolyl cis-trans isomerase activity
SLIP_RS01515	COG0740	serine-type endopeptidase activity
SLIP_RS01525	COG1067	ATP-dependent peptidase activity
SLIP_RS01525	COG0470	DNA polymerase III
SLIP_RS01530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SLIP_RS01535	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SLIP_RS01550	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SLIP_RS01555	COG4475	Protein of unknown function (DUF436)
SLIP_RS01565	COG1879	ABC-type sugar transport system periplasmic component
SLIP_RS01570	COG5012	cobalamin binding
SLIP_RS01575	COG1129	ABC transporter
SLIP_RS01580	COG1172	Belongs to the binding-protein-dependent transport system permease family
SLIP_RS01585	COG3693	PFAM glycoside hydrolase, family 10
SLIP_RS01630	COG1342	Belongs to the UPF0251 family
SLIP_RS01645	COG2894	cell division
SLIP_RS01680	COG2720	vancomycin resistance protein
SLIP_RS01695	COG3118	belongs to the thioredoxin family
SLIP_RS01705	COG0482	sulfurtransferase activity
SLIP_RS01715	COG0628	permease
SLIP_RS01720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SLIP_RS01725	COG4472	Bacterial protein of unknown function (DUF965)
SLIP_RS01735	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SLIP_RS01740	COG3906	Belongs to the UPF0473 family
SLIP_RS01745	COG2720	vancomycin resistance protein
SLIP_RS01750	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SLIP_RS01755	COG0826	peptidase U32
SLIP_RS01765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SLIP_RS01770	COG0768	penicillin binding
SLIP_RS01775	COG0745	RESPONSE REGULATOR receiver
SLIP_RS01780	COG5002	protein histidine kinase activity
SLIP_RS01785	COG0573	inorganic phosphate transmembrane transporter activity
SLIP_RS01790	COG0573	inorganic phosphate transmembrane transporter activity
SLIP_RS01795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SLIP_RS01800	COG0704	Plays a role in the regulation of phosphate uptake
SLIP_RS01810	COG1122	ATPase activity
SLIP_RS01820	COG0310	cobalt ion transport
SLIP_RS01825	COG0310	cobalt ion transport
SLIP_RS01845	COG3290	protein histidine kinase activity
SLIP_RS01850	COG3279	Response regulator of the LytR AlgR family
SLIP_RS01855	COG0375	protein maturation
SLIP_RS01860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SLIP_RS01880	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SLIP_RS01885	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SLIP_RS01910	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SLIP_RS01915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SLIP_RS01920	COG2165	general secretion pathway protein
SLIP_RS01925	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SLIP_RS01930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SLIP_RS01935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SLIP_RS01940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SLIP_RS01945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SLIP_RS01970	COG0312	modulator of DNA gyrase
SLIP_RS01975	COG0312	modulator of DNA gyrase
SLIP_RS01980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SLIP_RS01985	COG0006	proline dipeptidase activity
SLIP_RS01990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SLIP_RS02000	COG1847	R3H domain protein
SLIP_RS02010	COG3854	ATPases associated with a variety of cellular activities
SLIP_RS02055	COG0439	Biotin carboxylase
SLIP_RS02060	COG1302	Protein conserved in bacteria
SLIP_RS02075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SLIP_RS02080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SLIP_RS02085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SLIP_RS02090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SLIP_RS02095	COG1570	exodeoxyribonuclease VII activity
SLIP_RS02110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SLIP_RS02115	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SLIP_RS02120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SLIP_RS02125	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SLIP_RS02130	COG1438	arginine binding
SLIP_RS02135	COG0497	DNA recombination
SLIP_RS02140	COG0750	zinc metalloprotease
SLIP_RS02145	COG0745	RESPONSE REGULATOR receiver
SLIP_RS02150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SLIP_RS02175	COG2195	Cleaves the N-terminal amino acid of tripeptides
SLIP_RS02195	COG1379	DNA repair
SLIP_RS02205	COG1846	Transcriptional regulator
SLIP_RS02210	COG1960	acyl-CoA dehydrogenase activity
SLIP_RS02220	COG0644	oxidoreductase
SLIP_RS02230	COG2086	electron transfer activity
SLIP_RS02235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SLIP_RS02240	COG1024	Enoyl-CoA hydratase
SLIP_RS02245	COG0427	acetyl-CoA hydrolase
SLIP_RS02255	COG0183	Belongs to the thiolase family
SLIP_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
SLIP_RS02280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SLIP_RS02295	COG0840	transmembrane signaling receptor activity
SLIP_RS02305	COG0318	PFAM AMP-dependent synthetase and ligase
SLIP_RS02315	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SLIP_RS02325	COG0183	Belongs to the thiolase family
SLIP_RS02330	COG1960	acyl-CoA dehydrogenase activity
SLIP_RS02335	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLIP_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
SLIP_RS02350	COG1024	Enoyl-CoA hydratase
SLIP_RS02355	COG1024	Enoyl-CoA hydratase
SLIP_RS02375	COG1024	Enoyl-CoA hydratase
SLIP_RS02380	COG1300	Membrane
SLIP_RS02390	COG4974	Belongs to the 'phage' integrase family
SLIP_RS02395	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SLIP_RS02405	COG0517	IMP dehydrogenase activity
SLIP_RS02410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SLIP_RS02420	COG0183	Belongs to the thiolase family
SLIP_RS02425	COG0427	acetyl-CoA hydrolase
SLIP_RS02430	COG1960	acyl-CoA dehydrogenase activity
SLIP_RS02435	COG1024	Enoyl-CoA hydratase
SLIP_RS02440	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLIP_RS02445	COG3829	transcription factor binding
SLIP_RS02445	COG3290	protein histidine kinase activity
SLIP_RS02460	COG0154	amidase activity
SLIP_RS02465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SLIP_RS02470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SLIP_RS02475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SLIP_RS02480	COG0066	3-isopropylmalate dehydratase activity
SLIP_RS02485	COG0538	isocitrate dehydrogenase activity
SLIP_RS02505	COG1032	radical SAM domain protein
SLIP_RS02515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SLIP_RS02525	COG0297	glycogen (starch) synthase activity
SLIP_RS02530	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SLIP_RS02535	COG1074	ATP-dependent DNA helicase activity
SLIP_RS02545	COG0419	ATPase involved in DNA repair
SLIP_RS02550	COG1686	Belongs to the peptidase S11 family
SLIP_RS02560	COG2172	sigma factor antagonist activity
SLIP_RS02565	COG1191	sigma factor activity
SLIP_RS02575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SLIP_RS02595	COG1924	4 iron, 4 sulfur cluster binding
SLIP_RS02600	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SLIP_RS02605	COG0019	diaminopimelate decarboxylase activity
SLIP_RS02610	COG0617	tRNA 3'-terminal CCA addition
SLIP_RS02610	COG3620	sequence-specific DNA binding
SLIP_RS02610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SLIP_RS02615	COG1994	Peptidase M50
SLIP_RS02620	COG0180	Tryptophanyl-tRNA synthetase
SLIP_RS02625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SLIP_RS02630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SLIP_RS02665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SLIP_RS02690	COG3874	Sporulation protein YtfJ
SLIP_RS02695	COG2715	membrane protein required for spore maturation
SLIP_RS02700	COG0700	Nucleoside recognition
SLIP_RS02715	COG1573	uracil-dna glycosylase
SLIP_RS02720	COG0802	atpase or kinase
SLIP_RS02725	COG1214	PFAM Peptidase M22, glycoprotease
SLIP_RS02730	COG0456	acetyltransferase
SLIP_RS02735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SLIP_RS02745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SLIP_RS02750	COG1408	metallophosphoesterase
SLIP_RS02760	COG1910	domain protein
SLIP_RS02765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SLIP_RS02770	COG0315	cyclic pyranopterin monophosphate synthase activity
SLIP_RS02780	COG0521	Mo-molybdopterin cofactor biosynthetic process
SLIP_RS02780	COG0315	cyclic pyranopterin monophosphate synthase activity
SLIP_RS02785	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SLIP_RS02790	COG0459	protein refolding
SLIP_RS02805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLIP_RS02810	COG0183	Belongs to the thiolase family
SLIP_RS02820	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLIP_RS02825	COG1024	Enoyl-CoA hydratase
SLIP_RS02830	COG1960	acyl-CoA dehydrogenase activity
SLIP_RS02840	COG0318	PFAM AMP-dependent synthetase and ligase
SLIP_RS02845	COG2223	nitrite transmembrane transporter activity
SLIP_RS02860	COG0840	transmembrane signaling receptor activity
SLIP_RS02875	COG0519	Catalyzes the synthesis of GMP from XMP
SLIP_RS02875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SLIP_RS02880	COG1199	ATP-dependent helicase activity
SLIP_RS02890	COG3693	PFAM glycoside hydrolase, family 10
SLIP_RS02895	COG1191	sigma factor activity
SLIP_RS02900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SLIP_RS02905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SLIP_RS02910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SLIP_RS02915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SLIP_RS02920	COG0047	phosphoribosylformylglycinamidine synthase activity
SLIP_RS02925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SLIP_RS02930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SLIP_RS02935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SLIP_RS02940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SLIP_RS02945	COG0138	bifunctional purine biosynthesis protein purh
SLIP_RS02950	COG0151	Belongs to the GarS family
SLIP_RS02965	COG4496	protein, YerC YecD
SLIP_RS02970	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SLIP_RS02975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SLIP_RS02985	COG0131	Imidazoleglycerol-phosphate dehydratase
SLIP_RS02990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SLIP_RS02995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SLIP_RS03000	COG0107	imidazoleglycerol-phosphate synthase activity
SLIP_RS03005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SLIP_RS03005	COG0140	phosphoribosyl-ATP diphosphatase activity
SLIP_RS03010	COG0210	DNA helicase
SLIP_RS03015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SLIP_RS03065	COG1242	4 iron, 4 sulfur cluster binding
SLIP_RS03085	COG0297	glycogen (starch) synthase activity
SLIP_RS03090	COG1732	Glycine betaine
SLIP_RS03095	COG1174	glycine betaine transport
SLIP_RS03100	COG1174	glycine betaine transport
SLIP_RS03105	COG0517	IMP dehydrogenase activity
SLIP_RS03105	COG1125	glycine betaine transport
SLIP_RS03125	COG2843	Capsule synthesis protein
SLIP_RS03135	COG0579	oxidoreductase
SLIP_RS03155	COG1543	Belongs to the glycosyl hydrolase 57 family
SLIP_RS03190	COG0328	RNA-DNA hybrid ribonuclease activity
SLIP_RS03200	COG2111	Na H antiporter
SLIP_RS03200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SLIP_RS03210	COG3260	NADH ubiquinone oxidoreductase 20
SLIP_RS03220	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SLIP_RS03220	COG3261	NADH dehydrogenase
SLIP_RS03250	COG0427	acetyl-CoA hydrolase
SLIP_RS03260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLIP_RS03290	COG2385	sporulation resulting in formation of a cellular spore
SLIP_RS03300	COG2221	Nitrite and sulphite reductase 4Fe-4S
SLIP_RS03315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLIP_RS03325	COG0525	valine-tRNA ligase activity
SLIP_RS03330	COG0285	dihydrofolate synthase activity
SLIP_RS03340	COG0306	phosphate transporter
SLIP_RS03345	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SLIP_RS03355	COG0424	maF-like protein
SLIP_RS03360	COG2003	Belongs to the UPF0758 family
SLIP_RS03365	COG1077	Cell shape determining protein MreB Mrl
SLIP_RS03390	COG0850	regulation of cytokinetic process
SLIP_RS03395	COG2894	cell division
SLIP_RS03400	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SLIP_RS03405	COG0772	Belongs to the SEDS family
SLIP_RS03410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SLIP_RS03440	COG1530	ribonuclease E activity
SLIP_RS03445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SLIP_RS03455	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SLIP_RS03465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SLIP_RS03470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SLIP_RS03475	COG2414	aldehyde ferredoxin oxidoreductase
SLIP_RS03485	COG0653	protein targeting
SLIP_RS03510	COG3118	belongs to the thioredoxin family
SLIP_RS03525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SLIP_RS03530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SLIP_RS03585	COG1131	(ABC) transporter
SLIP_RS03590	COG1131	(ABC) transporter
SLIP_RS03595	COG0842	Transport permease protein
SLIP_RS03600	COG1309	transcriptional regulator
SLIP_RS03610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SLIP_RS03615	COG0646	methionine synthase
SLIP_RS03615	COG1410	methionine synthase
SLIP_RS03635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SLIP_RS03640	COG0217	transcriptional regulatory protein
SLIP_RS03650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SLIP_RS03655	COG0632	four-way junction helicase activity
SLIP_RS03660	COG2255	four-way junction helicase activity
SLIP_RS03665	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SLIP_RS03685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SLIP_RS03690	COG0343	queuine tRNA-ribosyltransferase activity
SLIP_RS03705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SLIP_RS03710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SLIP_RS03730	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SLIP_RS03735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLIP_RS03735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLIP_RS03740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLIP_RS03740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLIP_RS03755	COG0438	transferase activity, transferring glycosyl groups
SLIP_RS03760	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SLIP_RS03775	COG1230	cation diffusion facilitator family transporter
SLIP_RS03785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SLIP_RS03790	COG1490	D-aminoacyl-tRNA deacylase activity
SLIP_RS03795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLIP_RS03800	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SLIP_RS03805	COG0077	Prephenate dehydratase
SLIP_RS03805	COG1605	Chorismate mutase
SLIP_RS03810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SLIP_RS03815	COG0124	histidyl-tRNA synthetase
SLIP_RS03820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SLIP_RS03825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SLIP_RS03835	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SLIP_RS03855	COG1830	Aldolase
SLIP_RS03860	COG1063	alcohol dehydrogenase
SLIP_RS03865	COG0135	phosphoribosylanthranilate isomerase activity
SLIP_RS03875	COG2001	Belongs to the MraZ family
SLIP_RS03880	COG0275	rRNA processing
SLIP_RS03890	COG0768	penicillin binding
SLIP_RS03895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SLIP_RS03900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SLIP_RS03905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SLIP_RS03910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SLIP_RS03915	COG0772	Belongs to the SEDS family
SLIP_RS03920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SLIP_RS03925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SLIP_RS03930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SLIP_RS03935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SLIP_RS03940	COG0640	Transcriptional regulator
SLIP_RS03960	COG3856	small basic protein
SLIP_RS03970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SLIP_RS03980	COG1191	sigma factor activity
SLIP_RS03985	COG1191	sigma factor activity
SLIP_RS03990	COG1873	PFAM PRC-barrel domain
SLIP_RS03995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SLIP_RS04005	COG0602	queuosine metabolic process
SLIP_RS04010	COG1496	oxidoreductase activity
SLIP_RS04015	COG0745	RESPONSE REGULATOR receiver
SLIP_RS04020	COG5002	protein histidine kinase activity
SLIP_RS04030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SLIP_RS04035	COG1799	cell septum assembly
SLIP_RS04040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SLIP_RS04050	COG0826	peptidase U32
SLIP_RS04055	COG3599	regulation of cell shape
SLIP_RS04060	COG1872	DUF167
SLIP_RS04065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SLIP_RS04075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SLIP_RS04080	COG3830	Belongs to the UPF0237 family
SLIP_RS04085	COG2848	UPF0210 protein
SLIP_RS04090	COG0778	Nitroreductase
SLIP_RS04105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SLIP_RS04110	COG0438	transferase activity, transferring glycosyl groups
SLIP_RS04115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SLIP_RS04120	COG0564	pseudouridine synthase activity
SLIP_RS04125	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SLIP_RS04130	COG0540	Belongs to the ATCase OTCase family
SLIP_RS04135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SLIP_RS04140	COG0543	2 iron, 2 sulfur cluster binding
SLIP_RS04145	COG0167	dihydroorotate dehydrogenase activity
SLIP_RS04150	COG0284	orotidine-5'-phosphate decarboxylase activity
SLIP_RS04155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SLIP_RS04185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SLIP_RS04190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SLIP_RS04195	COG0436	Aminotransferase
SLIP_RS04200	COG1561	YicC-like family, N-terminal region
SLIP_RS04205	COG2052	Domain of unknown function (DUF370)
SLIP_RS04210	COG0194	GDP metabolic process
SLIP_RS04215	COG1758	RNA polymerase activity
SLIP_RS04220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SLIP_RS04225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SLIP_RS04230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SLIP_RS04235	COG0242	peptide deformylase activity
SLIP_RS04240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SLIP_RS04250	COG2738	Putative neutral zinc metallopeptidase
SLIP_RS04255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SLIP_RS04255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SLIP_RS04260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SLIP_RS04265	COG0631	protein serine/threonine phosphatase activity
SLIP_RS04270	COG0515	serine threonine protein kinase
SLIP_RS04270	COG2815	serine threonine protein kinase
SLIP_RS04275	COG1162	GTPase activity
SLIP_RS04280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SLIP_RS04295	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SLIP_RS04295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SLIP_RS04300	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SLIP_RS04305	COG1846	Transcriptional regulator
SLIP_RS04310	COG1960	acyl-CoA dehydrogenase activity
SLIP_RS04325	COG0644	oxidoreductase
SLIP_RS04330	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
SLIP_RS04335	COG3829	transcription factor binding
SLIP_RS04335	COG3290	protein histidine kinase activity
SLIP_RS04340	COG0183	Belongs to the thiolase family
SLIP_RS04345	COG1960	acyl-CoA dehydrogenase activity
SLIP_RS04350	COG0427	acetyl-CoA hydrolase
SLIP_RS04355	COG3290	protein histidine kinase activity
SLIP_RS04355	COG3829	transcription factor binding
SLIP_RS04360	COG1960	acyl-CoA dehydrogenase activity
SLIP_RS04380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SLIP_RS04385	COG1302	Protein conserved in bacteria
SLIP_RS04390	COG1461	Dihydroxyacetone kinase
SLIP_RS04395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SLIP_RS04405	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SLIP_RS04410	COG0742	ribosomal rna small subunit methyltransferase
SLIP_RS04420	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SLIP_RS04425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SLIP_RS04435	COG1752	Esterase of the alpha-beta hydrolase superfamily
SLIP_RS04440	COG1323	Belongs to the UPF0348 family
SLIP_RS04445	COG0280	phosphate acetyltransferase
SLIP_RS04450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SLIP_RS04460	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SLIP_RS04465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SLIP_RS04470	COG0228	four-way junction DNA binding
SLIP_RS04475	COG1837	Belongs to the UPF0109 family
SLIP_RS04480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SLIP_RS04485	COG0336	Belongs to the RNA methyltransferase TrmD family
SLIP_RS04490	COG4752	Belongs to the RNA methyltransferase TrmD family
SLIP_RS04495	COG0335	large ribosomal subunit rRNA binding
SLIP_RS04500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SLIP_RS04505	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SLIP_RS04515	COG2257	FlhB HrpN YscU SpaS Family
SLIP_RS04520	COG0792	nuclease activity
SLIP_RS04525	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SLIP_RS04580	COG1122	ATPase activity
SLIP_RS04590	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
SLIP_RS04595	COG0310	cobalt ion transport
SLIP_RS04605	COG1797	cobyrinic acid a,c-diamide synthase activity
SLIP_RS04610	COG1959	2 iron, 2 sulfur cluster binding
SLIP_RS04615	COG1151	hydroxylamine reductase activity
SLIP_RS04625	COG0606	chelatase, subunit chli
SLIP_RS04650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SLIP_RS04650	COG0758	DNA mediated transformation
SLIP_RS04655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SLIP_RS04660	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SLIP_RS04665	COG4974	Belongs to the 'phage' integrase family
SLIP_RS04670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SLIP_RS04675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SLIP_RS04685	COG1815	bacterial-type flagellum-dependent cell motility
SLIP_RS04690	COG1558	bacterial-type flagellum-dependent cell motility
SLIP_RS04700	COG1766	The M ring may be actively involved in energy transduction
SLIP_RS04705	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SLIP_RS04710	COG1317	bacterial-type flagellum organization
SLIP_RS04715	COG1157	protein secretion by the type III secretion system
SLIP_RS04735	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SLIP_RS04750	COG1582	Flagellar protein (FlbD)
SLIP_RS04760	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SLIP_RS04765	COG1776	CheC inhibitor of MCP methylation
SLIP_RS04765	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SLIP_RS04770	COG2201	protein-glutamate methylesterase activity
SLIP_RS04780	COG1338	Plays a role in the flagellum-specific transport system
SLIP_RS04785	COG1987	bacterial-type flagellum assembly
SLIP_RS04790	COG1684	flagellar biosynthetic protein fliR
SLIP_RS04795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SLIP_RS04800	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SLIP_RS04805	COG1419	protein localization to endoplasmic reticulum
SLIP_RS04820	COG2201	protein-glutamate methylesterase activity
SLIP_RS04825	COG0643	Histidine kinase
SLIP_RS04825	COG2198	Histidine kinase
SLIP_RS04830	COG0835	chemotaxis
SLIP_RS04835	COG1776	CheC inhibitor of MCP methylation
SLIP_RS04840	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SLIP_RS04845	COG1191	sigma factor activity
SLIP_RS04865	COG0052	Belongs to the universal ribosomal protein uS2 family
SLIP_RS04870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SLIP_RS04875	COG0528	UMP kinase activity
SLIP_RS04880	COG0233	cytoplasmic translational termination
SLIP_RS04895	COG0628	permease
SLIP_RS04900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SLIP_RS04905	COG0750	zinc metalloprotease
SLIP_RS04910	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SLIP_RS04915	COG0442	prolyl-tRNA aminoacylation
SLIP_RS04920	COG1285	pathogenesis
SLIP_RS04925	COG2176	DNA-directed DNA polymerase activity
SLIP_RS04930	COG0779	Required for maturation of 30S ribosomal subunits
SLIP_RS04935	COG0195	Participates in both transcription termination and antitermination
SLIP_RS04950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SLIP_RS04955	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SLIP_RS04965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SLIP_RS04970	COG0196	riboflavin kinase activity
SLIP_RS04975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SLIP_RS04980	COG1185	polyribonucleotide nucleotidyltransferase activity
SLIP_RS04985	COG2720	vancomycin resistance protein
SLIP_RS04990	COG0726	polysaccharide deacetylase
SLIP_RS04995	COG1686	Belongs to the peptidase S11 family
SLIP_RS05000	COG0612	Peptidase, M16
SLIP_RS05015	COG1873	PFAM PRC-barrel domain
SLIP_RS05030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SLIP_RS05045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SLIP_RS05045	COG1116	anion transmembrane transporter activity
SLIP_RS05050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SLIP_RS05055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SLIP_RS05060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SLIP_RS05065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SLIP_RS05070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SLIP_RS05075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SLIP_RS05080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SLIP_RS05080	COG0517	IMP dehydrogenase activity
SLIP_RS05085	COG2814	Major facilitator Superfamily
SLIP_RS05095	COG3383	formate dehydrogenase (NAD+) activity
SLIP_RS05100	COG0740	serine-type endopeptidase activity
SLIP_RS05110	COG0840	transmembrane signaling receptor activity
SLIP_RS05120	COG1968	undecaprenyl-diphosphatase activity
SLIP_RS05125	COG1674	ftsk spoiiie
SLIP_RS05135	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SLIP_RS05145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SLIP_RS05150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SLIP_RS05160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLIP_RS05175	COG1546	Belongs to the CinA family
SLIP_RS05175	COG1058	Belongs to the CinA family
SLIP_RS05180	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SLIP_RS05185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SLIP_RS05190	COG1418	mRNA catabolic process
SLIP_RS05195	COG1692	metallophosphoesterase
SLIP_RS05200	COG2359	stage V sporulation protein S
SLIP_RS05210	COG0613	PHP domain protein
SLIP_RS05215	COG0840	transmembrane signaling receptor activity
SLIP_RS05230	COG0517	IMP dehydrogenase activity
SLIP_RS05230	COG0516	GMP reductase activity
SLIP_RS05235	COG0824	Thioesterase
SLIP_RS05240	COG1285	pathogenesis
SLIP_RS05245	COG0697	spore germination
SLIP_RS05280	COG1307	EDD domain protein, DegV family
SLIP_RS05290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SLIP_RS05300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SLIP_RS05305	COG0145	ligase activity
SLIP_RS05315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SLIP_RS05320	COG2136	Putative SAM-dependent methyltransferase
SLIP_RS05320	COG2521	methyltransferase
SLIP_RS05325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SLIP_RS05330	COG1923	regulation of RNA biosynthetic process
SLIP_RS05335	COG0464	growth
SLIP_RS05340	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SLIP_RS05350	COG0174	glutamine synthetase
SLIP_RS05355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SLIP_RS05365	COG0247	lactate metabolic process
SLIP_RS05370	COG0277	FAD linked oxidase domain protein
SLIP_RS05375	COG3875	lactate racemase activity
SLIP_RS05380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SLIP_RS05385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SLIP_RS05400	COG1032	radical SAM domain protein
SLIP_RS05415	COG0688	phosphatidylethanolamine metabolic process
SLIP_RS05420	COG1183	phosphatidylcholine synthase activity
SLIP_RS05445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SLIP_RS05455	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
SLIP_RS05465	COG4651	solute:proton antiporter activity
SLIP_RS05465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SLIP_RS05470	COG2199	diguanylate cyclase activity
SLIP_RS05495	COG0012	GTP binding
SLIP_RS05525	COG5002	protein histidine kinase activity
SLIP_RS05540	COG1683	Conserved Protein
SLIP_RS05550	COG1307	EDD domain protein, DegV family
SLIP_RS05560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SLIP_RS05570	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SLIP_RS05575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SLIP_RS05590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SLIP_RS05730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SLIP_RS05735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLIP_RS05750	COG1615	UPF0182 protein
SLIP_RS05755	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SLIP_RS05760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SLIP_RS05765	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SLIP_RS05770	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SLIP_RS05785	COG1181	Belongs to the D-alanine--D-alanine ligase family
SLIP_RS05790	COG0613	PHP domain protein
SLIP_RS05800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SLIP_RS05805	COG4120	Belongs to the binding-protein-dependent transport system permease family
SLIP_RS05860	COG4970	Tfp pilus assembly protein FimT
SLIP_RS05870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SLIP_RS05875	COG4969	Belongs to the N-Me-Phe pilin family
SLIP_RS05920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SLIP_RS05935	COG2048	Heterodisulfide reductase, subunit B
SLIP_RS05945	COG1902	pentaerythritol trinitrate reductase activity
SLIP_RS05945	COG0446	pyridine nucleotide-disulphide oxidoreductase
SLIP_RS05960	COG3290	protein histidine kinase activity
SLIP_RS05960	COG3829	transcription factor binding
SLIP_RS05975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SLIP_RS05985	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SLIP_RS06000	COG0302	gtp cyclohydrolase
SLIP_RS06005	COG0602	queuosine metabolic process
SLIP_RS06015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SLIP_RS06020	COG0720	synthase
SLIP_RS06030	COG0428	transporter
SLIP_RS06040	COG0730	response to heat
SLIP_RS06070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SLIP_RS06085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SLIP_RS06105	COG3829	transcription factor binding
SLIP_RS06105	COG3290	protein histidine kinase activity
SLIP_RS06110	COG1024	Enoyl-CoA hydratase
SLIP_RS06120	COG0183	Belongs to the thiolase family
SLIP_RS06130	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLIP_RS06135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SLIP_RS06145	COG1960	acyl-CoA dehydrogenase activity
SLIP_RS06155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SLIP_RS06160	COG3829	transcription factor binding
SLIP_RS06160	COG3290	protein histidine kinase activity
SLIP_RS06195	COG0840	transmembrane signaling receptor activity
SLIP_RS06345	COG0402	S-adenosylhomocysteine deaminase activity
SLIP_RS06355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SLIP_RS06360	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SLIP_RS06365	COG0552	protein localization to endoplasmic reticulum
SLIP_RS06370	COG1196	nuclear chromosome segregation
SLIP_RS06385	COG0571	ribonuclease III activity
SLIP_RS06390	COG0416	fatty acid biosynthetic process
SLIP_RS06395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SLIP_RS06420	COG1131	(ABC) transporter
SLIP_RS06425	COG1725	Transcriptional regulator
SLIP_RS06500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SLIP_RS06510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SLIP_RS06515	COG1322	Protein conserved in bacteria
SLIP_RS06545	COG0631	protein serine/threonine phosphatase activity
SLIP_RS06575	COG1116	anion transmembrane transporter activity
SLIP_RS06585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SLIP_RS06600	COG0142	geranyltranstransferase activity
SLIP_RS06645	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SLIP_RS06650	COG1518	maintenance of DNA repeat elements
SLIP_RS06660	COG1203	CRISPR-associated helicase, Cas3
SLIP_RS06735	COG0516	GMP reductase activity
SLIP_RS06735	COG0517	IMP dehydrogenase activity
SLIP_RS06740	COG0398	Pfam SNARE associated Golgi protein
SLIP_RS06750	COG3290	protein histidine kinase activity
SLIP_RS06750	COG0840	transmembrane signaling receptor activity
SLIP_RS06775	COG1067	ATP-dependent peptidase activity
SLIP_RS06785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SLIP_RS06790	COG0598	Magnesium transport protein CorA
SLIP_RS06825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SLIP_RS06840	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SLIP_RS06865	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SLIP_RS06875	COG0436	Aminotransferase
SLIP_RS06880	COG1522	sequence-specific DNA binding
SLIP_RS06885	COG0446	pyridine nucleotide-disulphide oxidoreductase
SLIP_RS06905	COG1686	Belongs to the peptidase S11 family
SLIP_RS06910	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SLIP_RS06915	COG1051	belongs to the nudix hydrolase family
SLIP_RS06930	COG1307	EDD domain protein, DegV family
SLIP_RS06950	COG2442	InterPro IPR007367
SLIP_RS07005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SLIP_RS07010	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLIP_RS07015	COG0247	lactate metabolic process
SLIP_RS07015	COG2181	nitrate reductase activity
SLIP_RS07020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SLIP_RS07025	COG2086	electron transfer activity
SLIP_RS07030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SLIP_RS07035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SLIP_RS07040	COG1522	sequence-specific DNA binding
SLIP_RS07045	COG1522	sequence-specific DNA binding
SLIP_RS07050	COG0535	radical SAM domain protein
SLIP_RS07055	COG0113	porphobilinogen synthase activity
SLIP_RS07060	COG0535	radical SAM domain protein
SLIP_RS07070	COG0181	hydroxymethylbilane synthase activity
SLIP_RS07075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SLIP_RS07080	COG1648	precorrin-2 dehydrogenase activity
SLIP_RS07080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SLIP_RS07085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SLIP_RS07095	COG2864	formate dehydrogenase
SLIP_RS07100	COG0437	4 iron, 4 sulfur cluster binding
SLIP_RS07110	COG3383	formate dehydrogenase (NAD+) activity
SLIP_RS07110	COG0243	molybdopterin cofactor binding
SLIP_RS07115	COG0805	protein transport
SLIP_RS07125	COG1509	lysine 2,3-aminomutase activity
SLIP_RS07130	COG0163	prenyltransferase activity
SLIP_RS07135	COG0109	protoheme IX farnesyltransferase activity
SLIP_RS07140	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SLIP_RS07150	COG0825	malonyl-CoA metabolic process
SLIP_RS07155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SLIP_RS07160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SLIP_RS07165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SLIP_RS07170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SLIP_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
SLIP_RS07180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SLIP_RS07190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SLIP_RS07195	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SLIP_RS07205	COG0406	alpha-ribazole phosphatase activity
SLIP_RS07230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SLIP_RS07235	COG1120	ATPase activity
SLIP_RS07240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLIP_RS07245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SLIP_RS07260	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SLIP_RS07265	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SLIP_RS07270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SLIP_RS07280	COG0460	homoserine dehydrogenase
SLIP_RS07290	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SLIP_RS07295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SLIP_RS07300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SLIP_RS07305	COG1160	GTP binding
SLIP_RS07335	COG2333	competence protein COMEC
SLIP_RS07335	COG0658	competence protein
SLIP_RS07345	COG1304	FMN binding
SLIP_RS07350	COG0746	molybdenum cofactor guanylyltransferase activity
SLIP_RS07360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SLIP_RS07360	COG0539	negative regulation of cytoplasmic translation
SLIP_RS07365	COG0204	Acyl-transferase
SLIP_RS07370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SLIP_RS07380	COG3290	protein histidine kinase activity
SLIP_RS07385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLIP_RS07385	COG0072	phenylalanine-tRNA ligase activity
SLIP_RS07385	COG0072	phenylalanine-tRNA ligase activity
SLIP_RS07385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLIP_RS07390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SLIP_RS07395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SLIP_RS07400	COG0569	domain protein
SLIP_RS07405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SLIP_RS07410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SLIP_RS07415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SLIP_RS07425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SLIP_RS07455	COG1131	(ABC) transporter
SLIP_RS07470	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SLIP_RS07475	COG1793	dna ligase
SLIP_RS07480	COG3285	dna ligase
SLIP_RS07480	COG1793	dna ligase
SLIP_RS07500	COG0726	polysaccharide deacetylase
SLIP_RS07520	COG1253	flavin adenine dinucleotide binding
SLIP_RS07535	COG3409	Peptidoglycan-binding domain 1 protein
SLIP_RS07535	COG0860	N-Acetylmuramoyl-L-alanine amidase
SLIP_RS07540	COG0432	Pfam Uncharacterised protein family UPF0047
SLIP_RS07545	COG3359	exonuclease
SLIP_RS07550	COG1205	dead DEAH box helicase
SLIP_RS07550	COG1111	helicase
SLIP_RS07565	COG1136	(ABC) transporter
SLIP_RS07580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SLIP_RS07600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SLIP_RS07600	COG4624	Iron only hydrogenase large subunit, C-terminal domain
SLIP_RS07605	COG0728	peptidoglycan biosynthetic process
SLIP_RS07610	COG0426	domain, Protein
SLIP_RS07615	COG2033	superoxide reductase activity
SLIP_RS07640	COG1518	maintenance of DNA repeat elements
SLIP_RS07665	COG1203	CRISPR-associated helicase, Cas3
SLIP_RS07705	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SLIP_RS07715	COG0583	DNA-binding transcription factor activity
SLIP_RS07720	COG0719	Fe-S assembly protein
SLIP_RS07725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SLIP_RS07735	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SLIP_RS07740	COG0735	belongs to the Fur family
SLIP_RS07745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SLIP_RS07775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SLIP_RS07775	COG0493	'glutamate synthase
SLIP_RS07780	COG0069	glutamate synthase activity
SLIP_RS07785	COG0067	glutamate synthase
SLIP_RS07790	COG0174	glutamine synthetase
SLIP_RS07805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SLIP_RS07805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SLIP_RS07810	COG0004	ammonium transporteR
SLIP_RS07815	COG0347	Belongs to the P(II) protein family
SLIP_RS07820	COG0367	asparagine synthase
SLIP_RS07825	COG1160	GTP binding
SLIP_RS07830	COG1027	Aspartate ammonia-lyase
SLIP_RS07835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SLIP_RS07855	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SLIP_RS07870	COG1763	Mo-molybdopterin cofactor biosynthetic process
SLIP_RS07900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SLIP_RS07970	COG3409	Peptidoglycan-binding domain 1 protein
SLIP_RS07970	COG3267	Type II secretory pathway component ExeA
SLIP_RS08050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SLIP_RS08055	COG0358	DNA primase activity
SLIP_RS08075	COG0574	Belongs to the PEP-utilizing enzyme family
SLIP_RS08075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SLIP_RS08080	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SLIP_RS08085	COG0517	IMP dehydrogenase activity
SLIP_RS08090	COG0751	glycine-tRNA ligase activity
SLIP_RS08095	COG0752	glycyl-tRNA synthetase alpha subunit
SLIP_RS08115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SLIP_RS08120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SLIP_RS08125	COG0295	cytidine deaminase activity
SLIP_RS08130	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SLIP_RS08135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SLIP_RS08140	COG1480	7TM receptor with intracellular HD hydrolase
SLIP_RS08145	COG1702	phosphate starvation-inducible protein PhoH
SLIP_RS08170	COG0537	adenosine 5'-monophosphoramidase activity
SLIP_RS08180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SLIP_RS08185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SLIP_RS08190	COG2264	protein methyltransferase activity
SLIP_RS08195	COG0484	heat shock protein binding
SLIP_RS08200	COG0443	Heat shock 70 kDa protein
SLIP_RS08205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SLIP_RS08210	COG1420	regulation of RNA biosynthetic process
SLIP_RS08215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SLIP_RS08220	COG0481	GTPase activity
SLIP_RS08240	COG0268	Binds directly to 16S ribosomal RNA
SLIP_RS08250	COG1606	tRNA processing
SLIP_RS08255	COG2217	Heavy metal translocating P-type atpase
SLIP_RS08260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SLIP_RS08270	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SLIP_RS08275	COG2333	competence protein COMEC
SLIP_RS08275	COG0658	competence protein
SLIP_RS08280	COG1596	polysaccharide export
SLIP_RS08280	COG1555	photosystem II stabilization
SLIP_RS08290	COG0495	leucyl-tRNA aminoacylation
SLIP_RS08300	COG2508	Transcriptional regulator
SLIP_RS08310	COG1053	succinate dehydrogenase
SLIP_RS08335	COG1333	cytochrome c biogenesis protein
SLIP_RS08340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SLIP_RS08350	COG0799	negative regulation of ribosome biogenesis
SLIP_RS08355	COG1713	HD superfamily hydrolase involved in NAD metabolism
SLIP_RS08360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SLIP_RS08370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SLIP_RS08380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SLIP_RS08385	COG0318	PFAM AMP-dependent synthetase and ligase
SLIP_RS08410	COG0747	negative chemotaxis
SLIP_RS08415	COG0739	heme binding
SLIP_RS08415	COG1196	nuclear chromosome segregation
SLIP_RS08415	COG0741	lytic transglycosylase activity
SLIP_RS08420	COG0237	dephospho-CoA kinase activity
SLIP_RS08425	COG1971	Probably functions as a manganese efflux pump
SLIP_RS08430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SLIP_RS08475	COG0205	6-phosphofructokinase activity
SLIP_RS08535	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SLIP_RS08540	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SLIP_RS08550	COG0494	nUDIX hydrolase
SLIP_RS08555	COG1193	negative regulation of DNA recombination
SLIP_RS08560	COG0826	peptidase U32
SLIP_RS08580	COG2323	membrane
SLIP_RS08585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SLIP_RS08585	COG1796	DNA polymerase
SLIP_RS08590	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SLIP_RS08600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SLIP_RS08605	COG0745	RESPONSE REGULATOR receiver
SLIP_RS08610	COG0643	Histidine kinase
SLIP_RS08610	COG2198	Histidine kinase
SLIP_RS08615	COG1192	Involved in chromosome partitioning
SLIP_RS08625	COG0443	Heat shock 70 kDa protein
SLIP_RS08630	COG0840	transmembrane signaling receptor activity
SLIP_RS08630	COG3290	protein histidine kinase activity
SLIP_RS08635	COG0835	chemotaxis
SLIP_RS08640	COG2201	protein-glutamate methylesterase activity
SLIP_RS08645	COG2201	protein-glutamate methylesterase activity
SLIP_RS08655	COG1406	Chemotaxis phosphatase CheX
SLIP_RS08665	COG3290	protein histidine kinase activity
SLIP_RS08665	COG0840	transmembrane signaling receptor activity
SLIP_RS08670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SLIP_RS08675	COG0287	Prephenate dehydrogenase
SLIP_RS08680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SLIP_RS08685	COG0735	belongs to the Fur family
SLIP_RS08695	COG1121	(ABC) transporter
SLIP_RS08700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SLIP_RS08705	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SLIP_RS08710	COG0159	tryptophan synthase activity
SLIP_RS08715	COG0133	tryptophan synthase activity
SLIP_RS08720	COG0134	indole-3-glycerol-phosphate synthase activity
SLIP_RS08725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SLIP_RS08740	COG1725	Transcriptional regulator
SLIP_RS08745	COG1131	(ABC) transporter
SLIP_RS08795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SLIP_RS08815	COG1691	(AIR) carboxylase
SLIP_RS08845	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SLIP_RS08850	COG1639	'signal transduction protein
SLIP_RS08860	COG1187	pseudouridine synthase activity
SLIP_RS08870	COG1228	amidohydrolase
SLIP_RS08875	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SLIP_RS08880	COG2337	Toxic component of a toxin-antitoxin (TA) module
SLIP_RS08885	COG0864	Transcriptional regulator
SLIP_RS08890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SLIP_RS08895	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SLIP_RS08895	COG0617	tRNA 3'-terminal CCA addition
SLIP_RS08895	COG0517	IMP dehydrogenase activity
SLIP_RS08900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SLIP_RS08900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SLIP_RS08905	COG0736	holo-[acyl-carrier-protein] synthase activity
SLIP_RS08910	COG0835	chemotaxis
SLIP_RS08915	COG0604	alcohol dehydrogenase
SLIP_RS08940	COG2856	Zn peptidase
SLIP_RS09035	COG1484	DNA-dependent DNA replication
SLIP_RS09135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SLIP_RS09140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SLIP_RS09145	COG0557	exoribonuclease II activity
SLIP_RS09160	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SLIP_RS09165	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SLIP_RS09170	COG0148	phosphopyruvate hydratase activity
SLIP_RS09175	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SLIP_RS09180	COG0149	triose-phosphate isomerase activity
SLIP_RS09185	COG0126	phosphoglycerate kinase activity
SLIP_RS09200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SLIP_RS09205	COG1481	regulation of sporulation
SLIP_RS09210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SLIP_RS09215	COG1660	Displays ATPase and GTPase activities
SLIP_RS09220	COG2222	sugar isomerase
SLIP_RS09225	COG1940	carbohydrate kinase activity
SLIP_RS09235	COG0561	phosphatase activity
SLIP_RS09245	COG0322	excinuclease ABC activity
SLIP_RS09255	COG0556	nucleotide-excision repair
SLIP_RS09265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SLIP_RS09270	COG0793	Belongs to the peptidase S41A family
SLIP_RS09275	COG0739	heme binding
SLIP_RS09275	COG0741	lytic transglycosylase activity
SLIP_RS09275	COG1196	nuclear chromosome segregation
SLIP_RS09280	COG2177	Part of the ABC transporter FtsEX involved in
SLIP_RS09285	COG2884	Cell division ATP-binding protein ftsE
SLIP_RS09290	COG3958	Transketolase
SLIP_RS09295	COG3959	Transketolase, thiamine diphosphate binding domain
SLIP_RS09300	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SLIP_RS09310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SLIP_RS09315	COG0653	protein targeting
SLIP_RS09335	COG1516	flagellar protein fliS
SLIP_RS09355	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
SLIP_RS09415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SLIP_RS09440	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SLIP_RS09445	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SLIP_RS09450	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SLIP_RS09470	COG4786	Flagellar basal body rod
SLIP_RS09470	COG1256	bacterial-type flagellum assembly
SLIP_RS09490	COG1040	competence protein
SLIP_RS09555	COG2197	response regulator
SLIP_RS09560	COG4585	Histidine kinase
SLIP_RS09565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SLIP_RS09630	COG0270	DNA (cytosine-5-)-methyltransferase activity
SLIP_RS09640	COG1194	a g-specific adenine glycosylase
SLIP_RS09655	COG2323	membrane
SLIP_RS09660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SLIP_RS09670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SLIP_RS09680	COG1309	transcriptional regulator
SLIP_RS09690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SLIP_RS09745	COG1598	PFAM Uncharacterised protein family UPF0150
SLIP_RS09780	COG0582	viral genome integration into host DNA
SLIP_RS09795	COG1192	Involved in chromosome partitioning
SLIP_RS09820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SLIP_RS09825	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SLIP_RS09830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SLIP_RS09840	COG0183	Belongs to the thiolase family
SLIP_RS09855	COG0183	Belongs to the thiolase family
SLIP_RS09860	COG1024	Enoyl-CoA hydratase
SLIP_RS09865	COG3290	protein histidine kinase activity
SLIP_RS09865	COG3829	transcription factor binding
SLIP_RS09870	COG1024	Enoyl-CoA hydratase
SLIP_RS09895	COG1309	transcriptional regulator
SLIP_RS09910	COG0784	Response regulator, receiver
SLIP_RS09910	COG3437	response regulator, receiver
SLIP_RS09970	COG2003	Belongs to the UPF0758 family
SLIP_RS10025	COG0464	growth
SLIP_RS10035	COG1988	membrane-bound metal-dependent
SLIP_RS10135	COG4974	Belongs to the 'phage' integrase family
SLIP_RS10155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SLIP_RS10160	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SLIP_RS10175	COG1234	tRNA 3'-trailer cleavage
SLIP_RS10185	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SLIP_RS10190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SLIP_RS10215	COG3279	Response regulator of the LytR AlgR family
SLIP_RS10225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SLIP_RS10230	COG0446	pyridine nucleotide-disulphide oxidoreductase
SLIP_RS10230	COG1902	pentaerythritol trinitrate reductase activity
SLIP_RS10270	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SLIP_RS10285	COG0493	'glutamate synthase
SLIP_RS10290	COG0543	2 iron, 2 sulfur cluster binding
SLIP_RS10295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SLIP_RS10310	COG0477	Major facilitator Superfamily
SLIP_RS10315	COG1960	acyl-CoA dehydrogenase activity
SLIP_RS10325	COG0183	Belongs to the thiolase family
SLIP_RS10335	COG1028	Short-chain dehydrogenase reductase Sdr
SLIP_RS10340	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLIP_RS10345	COG1024	Enoyl-CoA hydratase
SLIP_RS10350	COG2030	dehydratase
SLIP_RS10355	COG0589	response to stress
SLIP_RS10360	COG0840	transmembrane signaling receptor activity
SLIP_RS10380	COG0641	radical SAM
SLIP_RS10385	COG1034	ATP synthesis coupled electron transport
SLIP_RS10405	COG2414	aldehyde ferredoxin oxidoreductase
SLIP_RS10410	COG0437	4 iron, 4 sulfur cluster binding
SLIP_RS10415	COG0493	'glutamate synthase
SLIP_RS10425	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SLIP_RS10430	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SLIP_RS10445	COG1960	acyl-CoA dehydrogenase activity
SLIP_RS10450	COG2086	electron transfer activity
SLIP_RS10455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SLIP_RS10480	COG0653	protein targeting
SLIP_RS10485	COG0347	Belongs to the P(II) protein family
SLIP_RS10490	COG0004	ammonium transporteR
SLIP_RS10495	COG0505	Belongs to the CarA family
SLIP_RS10500	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SLIP_RS10505	COG4149	molybdate abc transporter
SLIP_RS10515	COG1433	Dinitrogenase iron-molybdenum cofactor
SLIP_RS10515	COG0535	radical SAM domain protein
SLIP_RS10520	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SLIP_RS10525	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SLIP_RS10535	COG0347	Belongs to the P(II) protein family
SLIP_RS10540	COG0347	Belongs to the P(II) protein family
SLIP_RS10555	COG2200	EAL domain
SLIP_RS10575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SLIP_RS10580	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SLIP_RS10590	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SLIP_RS10595	COG1801	Protein of unknown function DUF72
SLIP_RS10600	COG0587	DNA-directed DNA polymerase activity
SLIP_RS10610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SLIP_RS10675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SLIP_RS10680	COG0473	3-isopropylmalate dehydrogenase activity
SLIP_RS10685	COG0066	3-isopropylmalate dehydratase activity
SLIP_RS10690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SLIP_RS10695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SLIP_RS10700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SLIP_RS10710	COG0028	Belongs to the TPP enzyme family
SLIP_RS10715	COG0129	dihydroxy-acid dehydratase activity
SLIP_RS10720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SLIP_RS10750	COG0165	Argininosuccinate lyase
SLIP_RS10755	COG0137	argininosuccinate synthase activity
SLIP_RS10765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SLIP_RS10770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SLIP_RS10775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SLIP_RS10780	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SLIP_RS10785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SLIP_RS10790	COG2226	methyltransferase
SLIP_RS10805	COG0095	Lipoate-protein ligase
SLIP_RS10810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SLIP_RS10815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SLIP_RS10840	COG0798	PFAM Bile acid sodium symporter
SLIP_RS10880	COG1024	Enoyl-CoA hydratase
SLIP_RS10890	COG2078	PFAM AMMECR1 domain protein
SLIP_RS10890	COG3885	ferrous iron binding
SLIP_RS10895	COG2247	cell wall binding repeat
SLIP_RS10895	COG0860	N-Acetylmuramoyl-L-alanine amidase
SLIP_RS10900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SLIP_RS10905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SLIP_RS10910	COG0101	tRNA pseudouridine synthase activity
SLIP_RS10915	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SLIP_RS10920	COG1122	ATPase activity
SLIP_RS10925	COG1122	ATPase activity
SLIP_RS10935	COG0202	RNA polymerase activity
SLIP_RS10940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SLIP_RS10945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SLIP_RS10950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SLIP_RS10955	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SLIP_RS10960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SLIP_RS10970	COG0024	Methionine aminopeptidase
SLIP_RS10975	COG0563	adenylate kinase activity
SLIP_RS10980	COG0201	protein transport
SLIP_RS10985	COG0200	Binds to the 23S rRNA
SLIP_RS10990	COG1841	ribosomal large subunit assembly
SLIP_RS10995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SLIP_RS11000	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SLIP_RS11010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SLIP_RS11015	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SLIP_RS11020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SLIP_RS11025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SLIP_RS11030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SLIP_RS11035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SLIP_RS11045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SLIP_RS11050	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SLIP_RS11055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SLIP_RS11060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SLIP_RS11065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SLIP_RS11070	COG0089	rRNA binding
SLIP_RS11075	COG0088	Forms part of the polypeptide exit tunnel
SLIP_RS11080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SLIP_RS11085	COG0051	transcription antitermination factor activity, RNA binding
SLIP_RS11090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SLIP_RS11095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SLIP_RS11100	COG0049	tRNA binding
SLIP_RS11105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SLIP_RS11110	COG1358	cellular component organization or biogenesis
SLIP_RS11115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SLIP_RS11120	COG0085	RNA polymerase activity
SLIP_RS11125	COG0222	ribosome binding
SLIP_RS11130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SLIP_RS11135	COG0081	regulation of translation
SLIP_RS11140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SLIP_RS11145	COG0250	Participates in transcription elongation, termination and antitermination
SLIP_RS11155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SLIP_RS11190	COG3688	RNA-binding protein containing a PIN domain
SLIP_RS11195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SLIP_RS11215	COG0215	cysteine-tRNA ligase activity
SLIP_RS11220	COG1045	serine acetyltransferase
SLIP_RS11225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SLIP_RS11230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SLIP_RS11235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SLIP_RS11240	COG4956	integral membrane protein (PIN domain superfamily)
SLIP_RS11250	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SLIP_RS11255	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SLIP_RS11260	COG0542	response to heat
SLIP_RS11265	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SLIP_RS11270	COG3880	PFAM UvrB UvrC protein
SLIP_RS11290	COG4786	Flagellar basal body rod
SLIP_RS11295	COG1077	Cell shape determining protein MreB Mrl
SLIP_RS11300	COG1609	Transcriptional regulator
SLIP_RS11305	COG2385	sporulation resulting in formation of a cellular spore
SLIP_RS11310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SLIP_RS11325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SLIP_RS11330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SLIP_RS11335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SLIP_RS11340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SLIP_RS11345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SLIP_RS11350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SLIP_RS11355	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SLIP_RS11360	COG0356	it plays a direct role in the translocation of protons across the membrane
SLIP_RS11380	COG0590	tRNA wobble adenosine to inosine editing
SLIP_RS11385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SLIP_RS11390	COG0698	ribose 5-phosphate isomerase
SLIP_RS11400	COG1971	Probably functions as a manganese efflux pump
SLIP_RS11405	COG0009	L-threonylcarbamoyladenylate synthase
SLIP_RS11410	COG2890	protein-(glutamine-N5) methyltransferase activity
SLIP_RS11415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SLIP_RS11420	COG3872	metal-dependent enzyme
SLIP_RS11425	COG0254	rRNA binding
SLIP_RS11435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SLIP_RS11445	COG0739	heme binding
SLIP_RS11450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SLIP_RS11460	COG1494	fructose-1,6-bisphosphatase
SLIP_RS11465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SLIP_RS11475	COG2204	response regulator
SLIP_RS11485	COG0616	signal peptide processing
SLIP_RS11490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SLIP_RS11500	COG0504	CTP synthase activity
SLIP_RS11505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SLIP_RS11515	COG0018	arginyl-trna synthetase
SLIP_RS11555	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SLIP_RS11560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SLIP_RS11570	COG0492	ferredoxin-NADP+ reductase activity
SLIP_RS11575	COG1196	nuclear chromosome segregation
SLIP_RS11575	COG0739	heme binding
SLIP_RS11575	COG0741	lytic transglycosylase activity
SLIP_RS11605	COG2801	Transposase and inactivated derivatives
SLIP_RS11620	COG2814	Major facilitator Superfamily
SLIP_RS11630	COG1309	transcriptional regulator
SLIP_RS11635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SLIP_RS11640	COG0359	binds to the 23S rRNA
SLIP_RS11650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SLIP_RS11655	COG0629	single-stranded DNA binding
SLIP_RS11660	COG0360	Binds together with S18 to 16S ribosomal RNA
SLIP_RS11665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SLIP_RS11665	COG0596	Alpha beta hydrolase
SLIP_RS11690	COG1362	aminopeptidase activity
SLIP_RS11705	COG0517	IMP dehydrogenase activity
SLIP_RS11705	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SLIP_RS11705	COG0617	tRNA 3'-terminal CCA addition
SLIP_RS11725	COG0559	Belongs to the binding-protein-dependent transport system permease family
SLIP_RS11735	COG1924	4 iron, 4 sulfur cluster binding
SLIP_RS11755	COG1921	L-seryl-tRNASec selenium transferase activity
SLIP_RS11760	COG3949	Membrane
SLIP_RS11795	COG1475	DNA binding
SLIP_RS11800	COG1192	Involved in chromosome partitioning
SLIP_RS11805	COG1475	DNA binding
SLIP_RS11810	COG0357	Ribosomal RNA small subunit methyltransferase G
SLIP_RS11815	COG0445	tRNA wobble uridine modification
SLIP_RS11820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SLIP_RS11825	COG1847	R3H domain protein
SLIP_RS11830	COG0706	membrane insertase activity
SLIP_RS11835	COG0594	ribonuclease P activity
SLIP_RS11855	COG1525	nuclease
SLIP_RS11880	COG1216	Glycosyl transferase, family 2
SLIP_RS11895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLIP_RS11910	COG2911	Protein conserved in bacteria
SLIP_RS11910	COG1361	Conserved repeat domain
SLIP_RS11910	COG3266	domain, Protein
SLIP_RS11950	COG1011	Hydrolase
SLIP_RS11965	COG0194	GDP metabolic process
SLIP_RS11970	COG2199	diguanylate cyclase activity
SLIP_RS11970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SLIP_RS11975	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SLIP_RS11975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SLIP_RS11995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SLIP_RS11995	COG1522	sequence-specific DNA binding
SLIP_RS12000	COG0791	NLP P60 protein
SLIP_RS12000	COG1388	LysM domain
SLIP_RS12035	COG3300	MHYT domain
SLIP_RS12035	COG5001	Diguanylate cyclase
SLIP_RS12050	COG2197	response regulator
SLIP_RS12090	COG3584	3D domain protein
SLIP_RS12090	COG1388	LysM domain
SLIP_RS12105	COG1215	transferase activity, transferring glycosyl groups
SLIP_RS12130	COG5632	N-Acetylmuramoyl-L-alanine amidase
SLIP_RS12130	COG3409	Peptidoglycan-binding domain 1 protein
SLIP_RS12135	COG1381	Involved in DNA repair and RecF pathway recombination
SLIP_RS12150	COG0840	transmembrane signaling receptor activity
SLIP_RS12155	COG0741	lytic transglycosylase activity
SLIP_RS12165	COG1396	sequence-specific DNA binding
SLIP_RS12195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs