locus-tag	class	description
SYN_RS00005	COG1475	DNA binding
SYN_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SYN_RS00020	COG0187	DNA topoisomerase II activity
SYN_RS00135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SYN_RS00195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYN_RS00200	COG1278	Cold shock
SYN_RS00210	COG1454	alcohol dehydrogenase
SYN_RS00220	COG1136	(ABC) transporter
SYN_RS00220	COG0577	efflux transmembrane transporter activity
SYN_RS00225	COG1136	(ABC) transporter
SYN_RS00230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_RS00235	COG0484	heat shock protein binding
SYN_RS00240	COG0459	protein refolding
SYN_RS00245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYN_RS00250	COG0071	Belongs to the small heat shock protein (HSP20) family
SYN_RS00295	COG0501	Belongs to the peptidase M48B family
SYN_RS00315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SYN_RS00315	COG0646	methionine synthase
SYN_RS00345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SYN_RS00350	COG0436	Aminotransferase
SYN_RS00355	COG0012	GTP binding
SYN_RS00360	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SYN_RS00385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYN_RS00390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SYN_RS00395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SYN_RS00405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SYN_RS00405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SYN_RS00420	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYN_RS00425	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYN_RS00450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYN_RS00455	COG1333	cytochrome c biogenesis protein
SYN_RS00470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SYN_RS00490	COG2414	aldehyde ferredoxin oxidoreductase
SYN_RS00515	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYN_RS00515	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYN_RS00515	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYN_RS00515	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN_RS00535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SYN_RS00535	COG1918	ferrous iron import across plasma membrane
SYN_RS00545	COG0004	ammonium transporteR
SYN_RS00550	COG0347	Belongs to the P(II) protein family
SYN_RS00560	COG2204	response regulator
SYN_RS00565	COG4191	Histidine kinase
SYN_RS00575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYN_RS00595	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
SYN_RS00610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYN_RS00615	COG0581	inorganic phosphate transmembrane transporter activity
SYN_RS00620	COG0573	inorganic phosphate transmembrane transporter activity
SYN_RS00625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYN_RS00635	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SYN_RS00660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SYN_RS00665	COG2878	Part of a membrane complex involved in electron transport
SYN_RS00665	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN_RS00670	COG3383	formate dehydrogenase (NAD+) activity
SYN_RS00675	COG3383	formate dehydrogenase (NAD+) activity
SYN_RS00690	COG0437	4 iron, 4 sulfur cluster binding
SYN_RS00695	COG0243	molybdopterin cofactor binding
SYN_RS00695	COG3383	formate dehydrogenase (NAD+) activity
SYN_RS00715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYN_RS00750	COG0528	UMP kinase activity
SYN_RS00820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SYN_RS00830	COG5002	protein histidine kinase activity
SYN_RS00835	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SYN_RS00845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYN_RS00850	COG0268	Binds directly to 16S ribosomal RNA
SYN_RS00860	COG0495	leucyl-tRNA aminoacylation
SYN_RS00865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYN_RS00870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SYN_RS00875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYN_RS00875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYN_RS00885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYN_RS00895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SYN_RS00900	COG0698	ribose 5-phosphate isomerase
SYN_RS00905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYN_RS00910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYN_RS00915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SYN_RS00925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYN_RS00940	COG1607	acyl-coa hydrolase
SYN_RS00960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SYN_RS00970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYN_RS00975	COG0778	Nitroreductase
SYN_RS00980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYN_RS01010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYN_RS01065	COG2270	Major facilitator Superfamily
SYN_RS01070	COG0514	ATP-dependent DNA helicase (RecQ)
SYN_RS01080	COG1960	acyl-CoA dehydrogenase activity
SYN_RS01085	COG1960	acyl-CoA dehydrogenase activity
SYN_RS01090	COG2197	response regulator
SYN_RS01105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYN_RS01110	COG1301	dicarboxylic acid transport
SYN_RS01120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYN_RS01125	COG4771	TonB-dependent receptor
SYN_RS01130	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SYN_RS01135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SYN_RS01160	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SYN_RS01185	COG1278	Cold shock
SYN_RS01200	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SYN_RS01205	COG0446	pyridine nucleotide-disulphide oxidoreductase
SYN_RS01220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYN_RS01225	COG1324	tolerance protein
SYN_RS01230	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SYN_RS01235	COG1331	Highly conserved protein containing a thioredoxin domain
SYN_RS01250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SYN_RS01250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SYN_RS01255	COG0142	geranyltranstransferase activity
SYN_RS01260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYN_RS01260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYN_RS01265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYN_RS01285	COG2853	Lipoprotein
SYN_RS01315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYN_RS01320	COG1674	ftsk spoiiie
SYN_RS01335	COG1561	YicC-like family, N-terminal region
SYN_RS01340	COG0194	GDP metabolic process
SYN_RS01345	COG1758	RNA polymerase activity
SYN_RS01350	COG0284	orotidine-5'-phosphate decarboxylase activity
SYN_RS01355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYN_RS01360	COG1459	type II secretion system
SYN_RS01375	COG0215	cysteine-tRNA ligase activity
SYN_RS01385	COG2078	PFAM AMMECR1 domain protein
SYN_RS01425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SYN_RS01430	COG0081	regulation of translation
SYN_RS01435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SYN_RS01440	COG0222	ribosome binding
SYN_RS01445	COG0085	RNA polymerase activity
SYN_RS01450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYN_RS01455	COG0049	tRNA binding
SYN_RS01460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SYN_RS01465	COG0051	transcription antitermination factor activity, RNA binding
SYN_RS01470	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SYN_RS01475	COG0088	Forms part of the polypeptide exit tunnel
SYN_RS01480	COG0089	rRNA binding
SYN_RS01485	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SYN_RS01490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SYN_RS01495	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SYN_RS01500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SYN_RS01505	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SYN_RS01510	COG0255	Belongs to the universal ribosomal protein uL29 family
SYN_RS01515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SYN_RS01520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SYN_RS01525	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SYN_RS01530	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SYN_RS01535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SYN_RS01540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SYN_RS01545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SYN_RS01550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SYN_RS01555	COG1841	ribosomal large subunit assembly
SYN_RS01560	COG0200	Binds to the 23S rRNA
SYN_RS01565	COG0201	protein transport
SYN_RS01575	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SYN_RS01580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SYN_RS01585	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SYN_RS01590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SYN_RS01595	COG0202	RNA polymerase activity
SYN_RS01600	COG0203	ribosomal protein L17
SYN_RS01610	COG1234	tRNA 3'-trailer cleavage
SYN_RS01615	COG0285	dihydrofolate synthase activity
SYN_RS01620	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SYN_RS01625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SYN_RS01630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SYN_RS01635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SYN_RS01640	COG0215	cysteine-tRNA ligase activity
SYN_RS01650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SYN_RS01655	COG2137	regulation of response to DNA damage stimulus
SYN_RS01660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SYN_RS01665	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SYN_RS01670	COG1546	Belongs to the CinA family
SYN_RS01670	COG1058	Belongs to the CinA family
SYN_RS01685	COG0426	domain, Protein
SYN_RS01685	COG1773	rubredoxin
SYN_RS01705	COG0655	NAD(P)H dehydrogenase (quinone) activity
SYN_RS01710	COG0586	Pfam SNARE associated Golgi protein
SYN_RS01735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYN_RS01740	COG0047	phosphoribosylformylglycinamidine synthase activity
SYN_RS01760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYN_RS01780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_RS01790	COG1067	ATP-dependent peptidase activity
SYN_RS01820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYN_RS01835	COG1960	acyl-CoA dehydrogenase activity
SYN_RS01840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SYN_RS01855	COG0438	transferase activity, transferring glycosyl groups
SYN_RS01860	COG0438	transferase activity, transferring glycosyl groups
SYN_RS01905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYN_RS01910	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SYN_RS01915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYN_RS02005	COG0463	Glycosyl transferase, family 2
SYN_RS02040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYN_RS02040	COG0438	transferase activity, transferring glycosyl groups
SYN_RS02065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYN_RS02085	COG0489	protein tyrosine kinase activity
SYN_RS02090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYN_RS02095	COG0134	indole-3-glycerol-phosphate synthase activity
SYN_RS02100	COG0135	phosphoribosylanthranilate isomerase activity
SYN_RS02115	COG0427	acetyl-CoA hydrolase
SYN_RS02150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYN_RS02155	COG0154	amidase activity
SYN_RS02160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYN_RS02170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SYN_RS02170	COG1042	CoA-binding domain protein
SYN_RS02170	COG0045	succinate-CoA ligase (ADP-forming) activity
SYN_RS02200	COG1151	hydroxylamine reductase activity
SYN_RS02210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYN_RS02235	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SYN_RS02265	COG0247	lactate metabolic process
SYN_RS02265	COG2181	nitrate reductase activity
SYN_RS02275	COG2414	aldehyde ferredoxin oxidoreductase
SYN_RS02315	COG0427	acetyl-CoA hydrolase
SYN_RS02320	COG2208	phosphoserine phosphatase activity
SYN_RS02330	COG2172	sigma factor antagonist activity
SYN_RS02335	COG1366	Belongs to the anti-sigma-factor antagonist family
SYN_RS02345	COG0671	phosphoesterase, PA-phosphatase related
SYN_RS02360	COG2217	Heavy metal translocating P-type atpase
SYN_RS02405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SYN_RS02590	COG4383	Mu-like prophage protein gp29
SYN_RS02600	COG5005	Phage virion morphogenesis
SYN_RS02615	COG4397	Mu-like prophage major head subunit gpT
SYN_RS02715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SYN_RS02720	COG2264	protein methyltransferase activity
SYN_RS02725	COG1648	precorrin-2 dehydrogenase activity
SYN_RS02725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYN_RS02730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYN_RS02735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SYN_RS02740	COG0181	hydroxymethylbilane synthase activity
SYN_RS02765	COG0535	radical SAM domain protein
SYN_RS02770	COG0113	porphobilinogen synthase activity
SYN_RS02775	COG0535	radical SAM domain protein
SYN_RS02780	COG1522	sequence-specific DNA binding
SYN_RS02785	COG0737	Belongs to the 5'-nucleotidase family
SYN_RS02795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYN_RS02795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYN_RS02800	COG1686	Belongs to the peptidase S11 family
SYN_RS02815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SYN_RS02895	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SYN_RS02925	COG1980	fructose-bisphosphate aldolase activity
SYN_RS02940	COG3041	Addiction module toxin RelE StbE family
SYN_RS02950	COG4974	Belongs to the 'phage' integrase family
SYN_RS02955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SYN_RS02960	COG1077	Cell shape determining protein MreB Mrl
SYN_RS02975	COG0768	penicillin binding
SYN_RS02980	COG0772	Belongs to the SEDS family
SYN_RS02985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYN_RS02990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYN_RS02995	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYN_RS03000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYN_RS03005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SYN_RS03010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SYN_RS03015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SYN_RS03020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SYN_RS03060	COG1704	LemA family
SYN_RS03065	COG1408	metallophosphoesterase
SYN_RS03070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SYN_RS03070	COG0617	tRNA 3'-terminal CCA addition
SYN_RS03070	COG3620	sequence-specific DNA binding
SYN_RS03075	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SYN_RS03085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SYN_RS03115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SYN_RS03120	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SYN_RS03125	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SYN_RS03130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SYN_RS03135	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SYN_RS03140	COG0072	phenylalanine-tRNA ligase activity
SYN_RS03145	COG0776	regulation of translation
SYN_RS03170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SYN_RS03185	COG0148	phosphopyruvate hydratase activity
SYN_RS03190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SYN_RS03195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SYN_RS03200	COG2001	Belongs to the MraZ family
SYN_RS03205	COG0275	rRNA processing
SYN_RS03210	COG3116	cell division
SYN_RS03215	COG0768	penicillin binding
SYN_RS03220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYN_RS03225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SYN_RS03230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYN_RS03235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SYN_RS03245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYN_RS03250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SYN_RS03255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SYN_RS03260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SYN_RS03270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SYN_RS03290	COG0835	chemotaxis
SYN_RS03305	COG2201	protein-glutamate methylesterase activity
SYN_RS03310	COG0708	Exodeoxyribonuclease III
SYN_RS03320	COG2223	nitrite transmembrane transporter activity
SYN_RS03335	COG0318	PFAM AMP-dependent synthetase and ligase
SYN_RS03350	COG1881	PFAM PEBP family protein
SYN_RS03365	COG0322	excinuclease ABC activity
SYN_RS03370	COG2119	membrane
SYN_RS03375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SYN_RS03380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYN_RS03385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SYN_RS03390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SYN_RS03410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SYN_RS03430	COG0579	oxidoreductase
SYN_RS03440	COG0009	L-threonylcarbamoyladenylate synthase
SYN_RS03445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SYN_RS03450	COG0138	bifunctional purine biosynthesis protein purh
SYN_RS03455	COG0151	Belongs to the GarS family
SYN_RS03460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SYN_RS03465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYN_RS03475	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SYN_RS03480	COG1418	mRNA catabolic process
SYN_RS03485	COG1692	metallophosphoesterase
SYN_RS03490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYN_RS03530	COG0217	transcriptional regulatory protein
SYN_RS03535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SYN_RS03540	COG0632	four-way junction helicase activity
SYN_RS03545	COG2255	four-way junction helicase activity
SYN_RS03550	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SYN_RS03570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SYN_RS03570	COG0574	Belongs to the PEP-utilizing enzyme family
SYN_RS03575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYN_RS03590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SYN_RS03600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYN_RS03620	COG0191	fructose-bisphosphate aldolase activity
SYN_RS03635	COG0837	glucose binding
SYN_RS03640	COG0166	Belongs to the GPI family
SYN_RS03645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_RS03655	COG1538	Outer membrane efflux protein
SYN_RS03670	COG0628	permease
SYN_RS03700	COG0419	ATPase involved in DNA repair
SYN_RS03705	COG0420	3'-5' exonuclease activity
SYN_RS03735	COG1945	arginine decarboxylase activity
SYN_RS03750	COG2197	response regulator
SYN_RS03770	COG0196	riboflavin kinase activity
SYN_RS03875	COG0210	DNA helicase
SYN_RS03880	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
SYN_RS03910	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SYN_RS03935	COG0504	CTP synthase activity
SYN_RS03955	COG0315	cyclic pyranopterin monophosphate synthase activity
SYN_RS03985	COG0438	transferase activity, transferring glycosyl groups
SYN_RS03995	COG0058	SHG alpha-glucan phosphorylase activity
SYN_RS04080	COG1560	Kdo2-lipid A biosynthetic process
SYN_RS04095	COG2835	tetraacyldisaccharide 4'-kinase activity
SYN_RS04105	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYN_RS04120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SYN_RS04125	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
SYN_RS04130	COG0811	peptide transport
SYN_RS04145	COG0823	Involved in the tonB-independent uptake of proteins
SYN_RS04150	COG2885	chlorophyll binding
SYN_RS04170	COG2861	carbohydrate metabolic process
SYN_RS04175	COG0793	Belongs to the peptidase S41A family
SYN_RS04200	COG0135	phosphoribosylanthranilate isomerase activity
SYN_RS04215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYN_RS04220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SYN_RS04225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SYN_RS04230	COG0058	SHG alpha-glucan phosphorylase activity
SYN_RS04235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYN_RS04275	COG1196	nuclear chromosome segregation
SYN_RS04350	COG1397	ADP-ribosylglycohydrolase
SYN_RS04380	COG1396	sequence-specific DNA binding
SYN_RS04385	COG3550	peptidyl-serine autophosphorylation
SYN_RS04430	COG5001	Diguanylate cyclase
SYN_RS04430	COG3447	MASE1 domain protein
SYN_RS04430	COG5002	protein histidine kinase activity
SYN_RS04475	COG5000	phosphorelay sensor kinase activity
SYN_RS04480	COG2204	response regulator
SYN_RS04490	COG0484	heat shock protein binding
SYN_RS04495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SYN_RS04500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_RS04505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SYN_RS04505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYN_RS04510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SYN_RS04515	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SYN_RS04520	COG2894	cell division
SYN_RS04525	COG0850	regulation of cytokinetic process
SYN_RS04540	COG0842	Transport permease protein
SYN_RS04545	COG0842	Transport permease protein
SYN_RS04550	COG2095	MarC family integral membrane protein
SYN_RS04555	COG1131	(ABC) transporter
SYN_RS04560	COG1131	(ABC) transporter
SYN_RS04565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_RS04580	COG4191	Histidine kinase
SYN_RS04585	COG2204	response regulator
SYN_RS04590	COG1815	bacterial-type flagellum-dependent cell motility
SYN_RS04600	COG1677	Flagellar hook-basal body complex protein FliE
SYN_RS04610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SYN_RS04620	COG1157	protein secretion by the type III secretion system
SYN_RS04650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SYN_RS04665	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYN_RS04675	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYN_RS04680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYN_RS04685	COG1127	ABC transporter
SYN_RS04690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SYN_RS04815	COG3328	transposase activity
SYN_RS04835	COG3089	Belongs to the UPF0270 family
SYN_RS04865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYN_RS04875	COG2135	peptidase activity
SYN_RS04895	COG0306	phosphate transporter
SYN_RS04915	COG1879	ABC-type sugar transport system periplasmic component
SYN_RS04925	COG2827	Endonuclease containing a URI domain
SYN_RS04950	COG1484	DNA-dependent DNA replication
SYN_RS04965	COG1309	transcriptional regulator
SYN_RS05015	COG0709	Synthesizes selenophosphate from selenide and ATP
SYN_RS05025	COG0583	DNA-binding transcription factor activity
SYN_RS05035	COG1773	rubredoxin
SYN_RS05035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYN_RS05045	COG1104	cysteine desulfurase activity
SYN_RS05050	COG1028	Short-chain dehydrogenase reductase Sdr
SYN_RS05055	COG1960	acyl-CoA dehydrogenase activity
SYN_RS05065	COG0428	transporter
SYN_RS05085	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYN_RS05090	COG3383	formate dehydrogenase (NAD+) activity
SYN_RS05095	COG3383	formate dehydrogenase (NAD+) activity
SYN_RS05105	COG2223	nitrite transmembrane transporter activity
SYN_RS05135	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYN_RS05155	COG3189	MarR family transcriptional regulator
SYN_RS05170	COG2204	response regulator
SYN_RS05175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYN_RS05200	COG1945	arginine decarboxylase activity
SYN_RS05205	COG4191	Histidine kinase
SYN_RS05210	COG0745	RESPONSE REGULATOR receiver
SYN_RS05240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYN_RS05255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYN_RS05285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYN_RS05290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SYN_RS05295	COG0424	maF-like protein
SYN_RS05315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SYN_RS05340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SYN_RS05345	COG1234	tRNA 3'-trailer cleavage
SYN_RS05355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SYN_RS05375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYN_RS05385	COG0706	membrane insertase activity
SYN_RS05390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SYN_RS05395	COG0594	ribonuclease P activity
SYN_RS05445	COG0484	heat shock protein binding
SYN_RS05455	COG0662	Cupin 2, conserved barrel domain protein
SYN_RS05460	COG0745	RESPONSE REGULATOR receiver
SYN_RS05460	COG2205	protein histidine kinase activity
SYN_RS05460	COG4191	Histidine kinase
SYN_RS05525	COG4974	Belongs to the 'phage' integrase family
SYN_RS05535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SYN_RS05540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SYN_RS05550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SYN_RS05555	COG0745	RESPONSE REGULATOR receiver
SYN_RS05565	COG0686	Belongs to the AlaDH PNT family
SYN_RS05570	COG0840	transmembrane signaling receptor activity
SYN_RS05585	COG0835	chemotaxis
SYN_RS05590	COG0745	RESPONSE REGULATOR receiver
SYN_RS05600	COG0840	transmembrane signaling receptor activity
SYN_RS05605	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SYN_RS05610	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SYN_RS05620	COG0745	RESPONSE REGULATOR receiver
SYN_RS05630	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SYN_RS05635	COG2201	protein-glutamate methylesterase activity
SYN_RS05640	COG0643	Histidine kinase
SYN_RS05640	COG2198	Histidine kinase
SYN_RS05655	COG1360	Flagellar Motor Protein
SYN_RS05675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYN_RS05680	COG1121	(ABC) transporter
SYN_RS05685	COG3443	Belongs to the bacterial solute-binding protein 9 family
SYN_RS05685	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYN_RS05695	COG4974	Belongs to the 'phage' integrase family
SYN_RS05705	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SYN_RS05710	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SYN_RS05730	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SYN_RS05735	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SYN_RS05740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SYN_RS05750	COG1660	Displays ATPase and GTPase activities
SYN_RS05760	COG1217	gtp-binding protein TYPA
SYN_RS05780	COG0427	acetyl-CoA hydrolase
SYN_RS05785	COG0427	acetyl-CoA hydrolase
SYN_RS05815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SYN_RS05830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SYN_RS05840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SYN_RS05845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SYN_RS05850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SYN_RS05860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SYN_RS05865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SYN_RS05875	COG0795	lipopolysaccharide-transporting ATPase activity
SYN_RS05890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SYN_RS05895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SYN_RS05900	COG4783	chaperone-mediated protein folding
SYN_RS05905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SYN_RS05915	COG0616	signal peptide processing
SYN_RS05920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYN_RS05925	COG0776	regulation of translation
SYN_RS05930	COG2003	Belongs to the UPF0758 family
SYN_RS05935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SYN_RS05940	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
SYN_RS05945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SYN_RS05950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SYN_RS05960	COG0799	negative regulation of ribosome biogenesis
SYN_RS05970	COG0601	transmembrane transport
SYN_RS05975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SYN_RS05990	COG0084	hydrolase, TatD family'
SYN_RS05995	COG1564	THIamine pyrophosphokinase
SYN_RS06000	COG0351	phosphomethylpyrimidine kinase
SYN_RS06000	COG0352	thiamine-phosphate diphosphorylase activity
SYN_RS06005	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SYN_RS06010	COG0617	tRNA 3'-terminal CCA addition
SYN_RS06015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYN_RS06050	COG2026	Addiction module toxin, RelE StbE family
SYN_RS06070	COG2304	oxidoreductase activity
SYN_RS06110	COG0489	protein tyrosine kinase activity
SYN_RS06130	COG4964	Belongs to the GSP D family
SYN_RS06160	COG0791	NLP P60 protein
SYN_RS06170	COG0719	Fe-S assembly protein
SYN_RS06175	COG1088	dTDP-glucose 4,6-dehydratase activity
SYN_RS06190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYN_RS06195	COG0497	DNA recombination
SYN_RS06215	COG0180	Tryptophanyl-tRNA synthetase
SYN_RS06220	COG1187	pseudouridine synthase activity
SYN_RS06235	COG3072	Adenylate cyclase
SYN_RS06240	COG1643	Atp-dependent helicase
SYN_RS06245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_RS06260	COG0543	2 iron, 2 sulfur cluster binding
SYN_RS06265	COG0456	acetyltransferase
SYN_RS06310	COG1776	CheC inhibitor of MCP methylation
SYN_RS06310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SYN_RS06320	COG1338	Plays a role in the flagellum-specific transport system
SYN_RS06330	COG1684	flagellar biosynthetic protein fliR
SYN_RS06335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SYN_RS06340	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SYN_RS06355	COG1191	sigma factor activity
SYN_RS06385	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SYN_RS06390	COG4787	bacterial-type flagellum-dependent cell motility
SYN_RS06400	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
SYN_RS06405	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SYN_RS06410	COG1706	bacterial-type flagellum-dependent cell motility
SYN_RS06425	COG4786	Flagellar basal body rod
SYN_RS06425	COG1256	bacterial-type flagellum assembly
SYN_RS06430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SYN_RS06435	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SYN_RS06440	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SYN_RS06495	COG0741	lytic transglycosylase activity
SYN_RS06500	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SYN_RS06505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SYN_RS06510	COG0758	DNA mediated transformation
SYN_RS06510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYN_RS06540	COG0137	argininosuccinate synthase activity
SYN_RS06545	COG0137	argininosuccinate synthase activity
SYN_RS06565	COG2801	Transposase and inactivated derivatives
SYN_RS06580	COG1773	rubredoxin
SYN_RS06600	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SYN_RS06605	COG2414	aldehyde ferredoxin oxidoreductase
SYN_RS06615	COG2181	nitrate reductase activity
SYN_RS06615	COG0247	lactate metabolic process
SYN_RS06660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYN_RS06675	COG0303	'Molybdopterin
SYN_RS06680	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SYN_RS06685	COG4149	molybdate abc transporter
SYN_RS06690	COG0725	ABC transporter, periplasmic molybdate-binding protein
SYN_RS06695	COG3585	molybdate ion transport
SYN_RS06710	COG1012	belongs to the aldehyde dehydrogenase family
SYN_RS06725	COG2414	aldehyde ferredoxin oxidoreductase
SYN_RS06750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYN_RS06760	COG4974	Belongs to the 'phage' integrase family
SYN_RS06765	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SYN_RS06770	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SYN_RS06775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SYN_RS06780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYN_RS06785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SYN_RS06790	COG0137	argininosuccinate synthase activity
SYN_RS06795	COG0165	Argininosuccinate lyase
SYN_RS06805	COG0019	diaminopimelate decarboxylase activity
SYN_RS06810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SYN_RS06815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SYN_RS06820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SYN_RS06835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SYN_RS06870	COG0444	Belongs to the ABC transporter superfamily
SYN_RS06875	COG4608	Belongs to the ABC transporter superfamily
SYN_RS06880	COG2945	thiolester hydrolase activity
SYN_RS06885	COG1278	Cold shock
SYN_RS06890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYN_RS06900	COG0402	S-adenosylhomocysteine deaminase activity
SYN_RS06905	COG1686	Belongs to the peptidase S11 family
SYN_RS06930	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SYN_RS06935	COG1074	ATP-dependent DNA helicase activity
SYN_RS06940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SYN_RS06970	COG0589	response to stress
SYN_RS06975	COG3706	GGDEF domain
SYN_RS06985	COG1295	ribonuclease BN
SYN_RS06995	COG0456	acetyltransferase
SYN_RS07000	COG0563	adenylate kinase activity
SYN_RS07010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYN_RS07015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYN_RS07020	COG0124	histidyl-tRNA synthetase
SYN_RS07025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SYN_RS07030	COG3852	Histidine kinase
SYN_RS07035	COG2204	response regulator
SYN_RS07040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYN_RS07040	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYN_RS07045	COG0535	radical SAM domain protein
SYN_RS07055	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SYN_RS07070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYN_RS07085	COG0573	inorganic phosphate transmembrane transporter activity
SYN_RS07090	COG0581	inorganic phosphate transmembrane transporter activity
SYN_RS07095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYN_RS07110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYN_RS07115	COG0459	protein refolding
SYN_RS07120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SYN_RS07125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SYN_RS07130	COG0107	imidazoleglycerol-phosphate synthase activity
SYN_RS07135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_RS07145	COG1136	(ABC) transporter
SYN_RS07155	COG4968	Prepilin-type N-terminal cleavage methylation domain
SYN_RS07180	COG1205	dead DEAH box helicase
SYN_RS07180	COG1111	helicase
SYN_RS07200	COG2921	Belongs to the UPF0250 family
SYN_RS07205	COG0028	Belongs to the TPP enzyme family
SYN_RS07210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SYN_RS07215	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SYN_RS07220	COG0534	Mate efflux family protein
SYN_RS07225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYN_RS07235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SYN_RS07240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SYN_RS07255	COG0037	tRNA processing
SYN_RS07260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN_RS07265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SYN_RS07270	COG0736	holo-[acyl-carrier-protein] synthase activity
SYN_RS07275	COG0802	atpase or kinase
SYN_RS07280	COG0527	aspartate kinase activity
SYN_RS07285	COG1555	photosystem II stabilization
SYN_RS07285	COG1596	polysaccharide export
SYN_RS07290	COG0741	lytic transglycosylase activity
SYN_RS07305	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYN_RS07310	COG0740	serine-type endopeptidase activity
SYN_RS07315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SYN_RS07340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SYN_RS07345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SYN_RS07350	COG1388	LysM domain
SYN_RS07350	COG0741	lytic transglycosylase activity
SYN_RS07355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SYN_RS07360	COG1480	7TM receptor with intracellular HD hydrolase
SYN_RS07370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SYN_RS07375	COG0612	Peptidase, M16
SYN_RS07380	COG0612	Peptidase, M16
SYN_RS07390	COG1032	radical SAM domain protein
SYN_RS07395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SYN_RS07400	COG1573	uracil-dna glycosylase
SYN_RS07430	COG1376	ErfK ybiS ycfS ynhG family protein
SYN_RS07440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYN_RS07445	COG0481	GTPase activity
SYN_RS07450	COG0563	adenylate kinase activity
SYN_RS07460	COG0436	Aminotransferase
SYN_RS07465	COG1254	Belongs to the acylphosphatase family
SYN_RS07470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYN_RS07500	COG0521	Mo-molybdopterin cofactor biosynthetic process
SYN_RS07505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYN_RS07510	COG0439	Biotin carboxylase
SYN_RS07515	COG0511	ligase activity, forming carbon-carbon bonds
SYN_RS07515	COG5016	pyruvate
SYN_RS07525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SYN_RS07530	COG0653	protein targeting
SYN_RS07535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SYN_RS07545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SYN_RS07550	COG0052	Belongs to the universal ribosomal protein uS2 family
SYN_RS07555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SYN_RS07560	COG0528	UMP kinase activity
SYN_RS07565	COG0233	cytoplasmic translational termination
SYN_RS07570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SYN_RS07585	COG0750	zinc metalloprotease
SYN_RS07590	COG1214	PFAM Peptidase M22, glycoprotease
SYN_RS07595	COG0688	phosphatidylethanolamine metabolic process
SYN_RS07600	COG1183	phosphatidylcholine synthase activity
SYN_RS07605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SYN_RS07610	COG0742	ribosomal rna small subunit methyltransferase
SYN_RS07615	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SYN_RS07620	COG0436	Aminotransferase
SYN_RS07625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYN_RS07630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SYN_RS07635	COG0442	prolyl-tRNA aminoacylation
SYN_RS07645	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYN_RS07650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SYN_RS07655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SYN_RS07675	COG1490	D-aminoacyl-tRNA deacylase activity
SYN_RS07685	COG0517	IMP dehydrogenase activity
SYN_RS07685	COG0516	GMP reductase activity
SYN_RS07700	COG0484	heat shock protein binding
SYN_RS07710	COG0824	Thioesterase
SYN_RS07715	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SYN_RS07725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SYN_RS07730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SYN_RS07735	COG0205	6-phosphofructokinase activity
SYN_RS07785	COG4942	peptidase
SYN_RS07820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYN_RS07935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYN_RS07950	COG2378	regulation of single-species biofilm formation
SYN_RS08110	COG0488	(ABC) transporter
SYN_RS08160	COG1484	DNA-dependent DNA replication
SYN_RS08165	COG4584	PFAM Integrase catalytic
SYN_RS08175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYN_RS08185	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SYN_RS08190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN_RS08200	COG0484	heat shock protein binding
SYN_RS08205	COG0071	Belongs to the small heat shock protein (HSP20) family
SYN_RS08210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYN_RS08215	COG0459	protein refolding
SYN_RS08245	COG0582	viral genome integration into host DNA
SYN_RS08250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SYN_RS08255	COG0037	tRNA processing
SYN_RS08265	COG3481	metal-dependent phosphohydrolase, HD sub domain
SYN_RS08275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYN_RS08280	COG0009	L-threonylcarbamoyladenylate synthase
SYN_RS08285	COG1530	ribonuclease E activity
SYN_RS08290	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SYN_RS08295	COG0762	integral membrane protein
SYN_RS08300	COG1872	DUF167
SYN_RS08305	COG0728	peptidoglycan biosynthetic process
SYN_RS08310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SYN_RS08345	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SYN_RS08350	COG0456	acetyltransferase
SYN_RS08365	COG0793	Belongs to the peptidase S41A family
SYN_RS08370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYN_RS08390	COG0776	regulation of translation
SYN_RS08420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYN_RS08430	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SYN_RS08440	COG1741	Belongs to the pirin family
SYN_RS08455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SYN_RS08460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYN_RS08475	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYN_RS08480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SYN_RS08490	COG0577	efflux transmembrane transporter activity
SYN_RS08490	COG1136	(ABC) transporter
SYN_RS08495	COG1136	(ABC) transporter
SYN_RS08500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_RS08515	COG1570	exodeoxyribonuclease VII activity
SYN_RS08520	COG1722	exodeoxyribonuclease VII activity
SYN_RS08530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SYN_RS08535	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SYN_RS08540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SYN_RS08550	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SYN_RS08555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN_RS08560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SYN_RS08565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYN_RS08570	COG1774	PSP1 C-terminal conserved region
SYN_RS08575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYN_RS08575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYN_RS08600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SYN_RS08605	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SYN_RS08630	COG0513	Belongs to the DEAD box helicase family
SYN_RS08645	COG2133	pyrroloquinoline quinone binding
SYN_RS08650	COG0287	Prephenate dehydrogenase
SYN_RS08650	COG1605	Chorismate mutase
SYN_RS08655	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SYN_RS08660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SYN_RS08665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SYN_RS08670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SYN_RS08675	COG0710	3-dehydroquinate dehydratase activity
SYN_RS08680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SYN_RS08685	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SYN_RS08690	COG0159	tryptophan synthase activity
SYN_RS08700	COG0135	phosphoribosylanthranilate isomerase activity
SYN_RS08705	COG0134	indole-3-glycerol-phosphate synthase activity
SYN_RS08710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYN_RS08715	COG0512	Glutamine amidotransferase of anthranilate synthase
SYN_RS08730	COG0598	Magnesium transport protein CorA
SYN_RS08750	COG0693	protein deglycase activity
SYN_RS08780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SYN_RS08785	COG1619	proteins homologs of microcin C7 resistance protein MccF
SYN_RS08790	COG2715	membrane protein required for spore maturation
SYN_RS08795	COG0700	Nucleoside recognition
SYN_RS08825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SYN_RS08830	COG0569	domain protein
SYN_RS08845	COG0402	S-adenosylhomocysteine deaminase activity
SYN_RS08850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SYN_RS08860	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SYN_RS08875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYN_RS08880	COG0443	Heat shock 70 kDa protein
SYN_RS08890	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SYN_RS08900	COG0488	(ABC) transporter
SYN_RS08905	COG2050	protein possibly involved in aromatic compounds catabolism
SYN_RS08910	COG1271	oxidase subunit
SYN_RS08915	COG1294	oxidase, subunit
SYN_RS08920	COG1970	mechanosensitive ion channel activity
SYN_RS08940	COG2823	Periplasmic or secreted lipoprotein
SYN_RS08960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SYN_RS08970	COG0359	binds to the 23S rRNA
SYN_RS08975	COG0305	Participates in initiation and elongation during chromosome replication
SYN_RS08980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYN_RS08985	COG0542	response to heat
SYN_RS08990	COG0501	Belongs to the peptidase M48B family
SYN_RS09000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SYN_RS09010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SYN_RS09015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SYN_RS09020	COG0193	aminoacyl-tRNA hydrolase activity
SYN_RS09025	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SYN_RS09030	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SYN_RS09040	COG2204	response regulator
SYN_RS09055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYN_RS09065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYN_RS09070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SYN_RS09075	COG1950	PFAM Membrane protein of
SYN_RS09085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SYN_RS09090	COG0791	NLP P60 protein
SYN_RS09095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYN_RS09105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SYN_RS09145	COG1250	3-hydroxyacyl-CoA dehydrogenase
SYN_RS09150	COG1024	Enoyl-CoA hydratase
SYN_RS09155	COG1469	GTP cyclohydrolase I activity
SYN_RS09170	COG1403	HNH endonuclease
SYN_RS09200	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYN_RS09215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SYN_RS09225	COG4451	ribulose bisphosphate carboxylase, small
SYN_RS09225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYN_RS09230	COG0237	dephospho-CoA kinase activity
SYN_RS09245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SYN_RS09245	COG1042	CoA-binding domain protein
SYN_RS09245	COG0045	succinate-CoA ligase (ADP-forming) activity
SYN_RS09250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN_RS09255	COG0058	SHG alpha-glucan phosphorylase activity
SYN_RS09265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SYN_RS09280	COG0525	valine-tRNA ligase activity
SYN_RS09290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYN_RS09295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SYN_RS09310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_RS09340	COG1091	dTDP-4-dehydrorhamnose reductase activity
SYN_RS09350	COG0126	phosphoglycerate kinase activity
SYN_RS09355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SYN_RS09360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYN_RS09365	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SYN_RS09370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SYN_RS09375	COG4956	integral membrane protein (PIN domain superfamily)
SYN_RS09395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SYN_RS09405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SYN_RS09410	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SYN_RS09425	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SYN_RS09445	COG2022	thiamine diphosphate biosynthetic process
SYN_RS09455	COG0352	thiamine-phosphate diphosphorylase activity
SYN_RS09475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYN_RS09490	COG0741	lytic transglycosylase activity
SYN_RS09490	COG0739	heme binding
SYN_RS09490	COG1196	nuclear chromosome segregation
SYN_RS09530	COG1459	type II secretion system
SYN_RS09535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYN_RS09560	COG2226	methyltransferase
SYN_RS09570	COG0552	protein localization to endoplasmic reticulum
SYN_RS09575	COG0488	(ABC) transporter
SYN_RS09585	COG1283	sodium-dependent phosphate transmembrane transporter activity
SYN_RS09590	COG1592	Rubrerythrin
SYN_RS09610	COG0432	Pfam Uncharacterised protein family UPF0047
SYN_RS09615	COG1691	(AIR) carboxylase
SYN_RS09620	COG1606	tRNA processing
SYN_RS09625	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SYN_RS09630	COG0864	Transcriptional regulator
SYN_RS09640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYN_RS09655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SYN_RS09665	COG1199	ATP-dependent helicase activity
SYN_RS09740	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SYN_RS09755	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SYN_RS09850	COG1846	Transcriptional regulator
SYN_RS09860	COG0280	phosphate acetyltransferase
SYN_RS09865	COG3426	butyrate kinase activity
SYN_RS09900	COG0076	glutamate decarboxylase activity
SYN_RS09910	COG3040	lipid binding
SYN_RS09915	COG2226	methyltransferase
SYN_RS09940	COG0534	Mate efflux family protein
SYN_RS09950	COG0433	COG0433 Predicted ATPase
SYN_RS09980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYN_RS10020	COG1874	Beta-galactosidase
SYN_RS10020	COG0366	Alpha amylase catalytic
SYN_RS10025	COG2321	neutral zinc metallopeptidase
SYN_RS10035	COG3647	Membrane
SYN_RS10045	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYN_RS10050	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYN_RS10055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYN_RS10070	COG0582	viral genome integration into host DNA
SYN_RS10135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SYN_RS10145	COG1837	Belongs to the UPF0109 family
SYN_RS10190	COG2816	NAD+ diphosphatase activity
SYN_RS10205	COG1937	Protein conserved in bacteria
SYN_RS10210	COG3064	Membrane
SYN_RS10210	COG0437	4 iron, 4 sulfur cluster binding
SYN_RS10235	COG0484	heat shock protein binding
SYN_RS10255	COG0564	pseudouridine synthase activity
SYN_RS10260	COG2081	HI0933 family
SYN_RS10305	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYN_RS10310	COG1305	Transglutaminase-like
SYN_RS10325	COG1136	(ABC) transporter
SYN_RS10330	COG0577	efflux transmembrane transporter activity
SYN_RS10340	COG0045	succinate-CoA ligase (ADP-forming) activity
SYN_RS10340	COG1042	CoA-binding domain protein
SYN_RS10340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SYN_RS10360	COG1534	Rna-binding protein
SYN_RS10380	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SYN_RS10390	COG0358	DNA primase activity
SYN_RS10395	COG1610	YqeY-like protein
SYN_RS10400	COG0537	adenosine 5'-monophosphoramidase activity
SYN_RS10405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SYN_RS10415	COG0131	Imidazoleglycerol-phosphate dehydratase
SYN_RS10425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SYN_RS10460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SYN_RS10465	COG3956	TIGRFAM MazG family protein
SYN_RS10475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SYN_RS10480	COG0343	queuine tRNA-ribosyltransferase activity
SYN_RS10490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYN_RS10495	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYN_RS10510	COG1914	H( )-stimulated, divalent metal cation uptake system
SYN_RS10515	COG2239	Acts as a magnesium transporter
SYN_RS10520	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SYN_RS10525	COG0540	Belongs to the ATCase OTCase family
SYN_RS10530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SYN_RS10535	COG2239	Acts as a magnesium transporter
SYN_RS10540	COG1381	Involved in DNA repair and RecF pathway recombination
SYN_RS10545	COG0752	glycyl-tRNA synthetase alpha subunit
SYN_RS10550	COG0751	glycine-tRNA ligase activity
SYN_RS10560	COG0589	response to stress
SYN_RS10605	COG1459	type II secretion system
SYN_RS10650	COG0720	synthase
SYN_RS10655	COG0602	queuosine metabolic process
SYN_RS10660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SYN_RS10670	COG1663	tetraacyldisaccharide 4'-kinase activity
SYN_RS10675	COG1132	(ABC) transporter
SYN_RS10680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYN_RS10685	COG0673	inositol 2-dehydrogenase activity
SYN_RS10690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYN_RS10695	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYN_RS10710	COG1136	(ABC) transporter
SYN_RS10720	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SYN_RS10730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYN_RS10740	COG0483	inositol monophosphate 1-phosphatase activity
SYN_RS10755	COG1305	Transglutaminase-like
SYN_RS10770	COG0463	Glycosyl transferase, family 2
SYN_RS10780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYN_RS10785	COG2226	methyltransferase
SYN_RS10805	COG1216	Glycosyl transferase, family 2
SYN_RS10825	COG0438	transferase activity, transferring glycosyl groups
SYN_RS10830	COG0438	transferase activity, transferring glycosyl groups
SYN_RS10845	COG4968	Prepilin-type N-terminal cleavage methylation domain
SYN_RS10900	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
SYN_RS10930	COG0482	sulfurtransferase activity
SYN_RS10935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYN_RS10940	COG0571	ribonuclease III activity
SYN_RS10950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SYN_RS10955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SYN_RS10960	COG1160	GTP binding
SYN_RS11000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYN_RS11020	COG0489	protein tyrosine kinase activity
SYN_RS11025	COG3409	Peptidoglycan-binding domain 1 protein
SYN_RS11025	COG3267	Type II secretory pathway component ExeA
SYN_RS11035	COG4191	Histidine kinase
SYN_RS11045	COG1131	(ABC) transporter
SYN_RS11055	COG0792	nuclease activity
SYN_RS11060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SYN_RS11065	COG0335	large ribosomal subunit rRNA binding
SYN_RS11070	COG4752	Belongs to the RNA methyltransferase TrmD family
SYN_RS11075	COG0336	Belongs to the RNA methyltransferase TrmD family
SYN_RS11080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SYN_RS11085	COG1837	Belongs to the UPF0109 family
SYN_RS11090	COG0228	four-way junction DNA binding
SYN_RS11095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SYN_RS11105	COG0018	arginyl-trna synthetase
SYN_RS11115	COG4966	pilus assembly protein PilW
SYN_RS11140	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SYN_RS11150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYN_RS11150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYN_RS11155	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SYN_RS11165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYN_RS11170	COG1522	sequence-specific DNA binding
SYN_RS11175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SYN_RS11180	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SYN_RS11185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYN_RS11200	COG0356	it plays a direct role in the translocation of protons across the membrane
SYN_RS11205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SYN_RS11210	COG2204	response regulator
SYN_RS11225	COG0375	protein maturation
SYN_RS11230	COG0298	carbon dioxide binding
SYN_RS11240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SYN_RS11245	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SYN_RS11265	COG0437	4 iron, 4 sulfur cluster binding
SYN_RS11275	COG0493	'glutamate synthase
SYN_RS11280	COG0543	2 iron, 2 sulfur cluster binding
SYN_RS11290	COG0556	nucleotide-excision repair
SYN_RS11295	COG1119	ATPase activity
SYN_RS11300	COG1073	alpha beta
SYN_RS11305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYN_RS11325	COG0613	PHP domain protein
SYN_RS11390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SYN_RS11410	COG1278	Cold shock
SYN_RS11430	COG3360	Dodecin
SYN_RS11450	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYN_RS11450	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYN_RS11455	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYN_RS11465	COG0045	succinate-CoA ligase (ADP-forming) activity
SYN_RS11470	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SYN_RS11535	COG1832	CoA-binding protein
SYN_RS11550	COG1592	Rubrerythrin
SYN_RS11560	COG1253	flavin adenine dinucleotide binding
SYN_RS11570	COG3426	butyrate kinase activity
SYN_RS11575	COG0280	phosphate acetyltransferase
SYN_RS11585	COG0549	Belongs to the carbamate kinase family
SYN_RS11595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SYN_RS11610	COG2223	nitrite transmembrane transporter activity
SYN_RS11640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYN_RS11650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYN_RS11670	COG0655	NAD(P)H dehydrogenase (quinone) activity
SYN_RS11705	COG0517	IMP dehydrogenase activity
SYN_RS11740	COG2076	Multidrug Resistance protein
SYN_RS11750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SYN_RS11760	COG1104	cysteine desulfurase activity
SYN_RS11770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYN_RS11780	COG0482	sulfurtransferase activity
SYN_RS11785	COG1045	serine acetyltransferase
SYN_RS11795	COG2890	protein-(glutamine-N5) methyltransferase activity
SYN_RS11800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SYN_RS11805	COG1959	2 iron, 2 sulfur cluster binding
SYN_RS11835	COG0726	polysaccharide deacetylase
SYN_RS11835	COG1649	PFAM Uncharacterised BCR, COG1649
SYN_RS11845	COG1215	transferase activity, transferring glycosyl groups
SYN_RS11855	COG0577	efflux transmembrane transporter activity
SYN_RS11855	COG1136	(ABC) transporter
SYN_RS11860	COG1136	(ABC) transporter
SYN_RS11860	COG0577	efflux transmembrane transporter activity
SYN_RS11865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_RS11880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SYN_RS11890	COG0471	metal ion transport
SYN_RS11905	COG2116	formate transmembrane transporter activity
SYN_RS11930	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SYN_RS11965	COG0489	protein tyrosine kinase activity
SYN_RS11975	COG0489	protein tyrosine kinase activity
SYN_RS11980	COG1945	arginine decarboxylase activity
SYN_RS11995	COG2204	response regulator
SYN_RS12035	COG0731	radical SAM domain protein
SYN_RS12035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYN_RS12065	COG0247	lactate metabolic process
SYN_RS12065	COG2181	nitrate reductase activity
SYN_RS12095	COG0725	ABC transporter, periplasmic molybdate-binding protein
SYN_RS12105	COG3842	ATPase activity
SYN_RS12115	COG0489	protein tyrosine kinase activity
SYN_RS12130	COG0655	NAD(P)H dehydrogenase (quinone) activity
SYN_RS12150	COG0473	3-isopropylmalate dehydrogenase activity
SYN_RS12155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYN_RS12160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYN_RS12165	COG0066	3-isopropylmalate dehydratase activity
SYN_RS12170	COG0430	RNA-3'-phosphate cyclase activity
SYN_RS12190	COG1410	methionine synthase
SYN_RS12190	COG0646	methionine synthase
SYN_RS12195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SYN_RS12200	COG0101	tRNA pseudouridine synthase activity
SYN_RS12205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SYN_RS12210	COG0436	Aminotransferase
SYN_RS12240	COG0489	protein tyrosine kinase activity
SYN_RS12240	COG3206	protein involved in exopolysaccharide biosynthesis
SYN_RS12250	COG4453	Protein conserved in bacteria
SYN_RS12260	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SYN_RS12270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYN_RS12275	COG0110	maltose O-acetyltransferase activity
SYN_RS12280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SYN_RS12320	COG0367	asparagine synthase
SYN_RS12325	COG0673	inositol 2-dehydrogenase activity
SYN_RS12345	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SYN_RS12345	COG0662	Cupin 2, conserved barrel domain protein
SYN_RS12365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYN_RS12370	COG0702	epimerase
SYN_RS12375	COG0438	transferase activity, transferring glycosyl groups
SYN_RS12385	COG1215	transferase activity, transferring glycosyl groups
SYN_RS12405	COG1216	Glycosyl transferase, family 2
SYN_RS12460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYN_RS12485	COG0318	PFAM AMP-dependent synthetase and ligase
SYN_RS12490	COG0183	Belongs to the thiolase family
SYN_RS12495	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SYN_RS12500	COG0318	PFAM AMP-dependent synthetase and ligase
SYN_RS12510	COG2181	nitrate reductase activity
SYN_RS12510	COG0247	lactate metabolic process
SYN_RS12515	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SYN_RS12520	COG2086	electron transfer activity
SYN_RS12525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYN_RS12545	COG1519	Transferase
SYN_RS12545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SYN_RS12550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SYN_RS12570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SYN_RS12575	COG0509	glycine decarboxylation via glycine cleavage system
SYN_RS12620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SYN_RS12630	COG0756	dUTP diphosphatase activity
SYN_RS12635	COG1185	polyribonucleotide nucleotidyltransferase activity
SYN_RS12640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SYN_RS12645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SYN_RS12650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SYN_RS12655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SYN_RS12660	COG1550	Protein conserved in bacteria
SYN_RS12665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYN_RS12670	COG0195	Participates in both transcription termination and antitermination
SYN_RS12675	COG0779	Required for maturation of 30S ribosomal subunits
SYN_RS12685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SYN_RS12690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYN_RS12695	COG2890	protein-(glutamine-N5) methyltransferase activity
SYN_RS12700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYN_RS12705	COG0254	rRNA binding
SYN_RS12710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SYN_RS12715	COG1496	oxidoreductase activity
SYN_RS12720	COG0564	pseudouridine synthase activity
SYN_RS12725	COG1921	L-seryl-tRNASec selenium transferase activity
SYN_RS12730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYN_RS12740	COG1234	tRNA 3'-trailer cleavage
SYN_RS12755	COG4191	Histidine kinase
SYN_RS12780	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN_RS12785	COG0251	oxidation-reduction process
SYN_RS12800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYN_RS12810	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SYN_RS12815	COG0352	thiamine-phosphate diphosphorylase activity
SYN_RS12830	COG0058	SHG alpha-glucan phosphorylase activity
SYN_RS12835	COG2226	methyltransferase
SYN_RS12840	COG0366	Alpha amylase catalytic
SYN_RS12845	COG0501	Belongs to the peptidase M48B family
SYN_RS12855	COG0328	RNA-DNA hybrid ribonuclease activity
SYN_RS12865	COG1763	Mo-molybdopterin cofactor biosynthetic process
SYN_RS12880	COG1796	DNA polymerase
SYN_RS12880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SYN_RS12890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SYN_RS12905	COG1518	maintenance of DNA repeat elements
SYN_RS12940	COG3328	transposase activity
SYN_RS12955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_RS12970	COG0784	Response regulator, receiver
SYN_RS12970	COG4191	Histidine kinase
SYN_RS12975	COG0745	RESPONSE REGULATOR receiver
SYN_RS12985	COG1335	isochorismatase
SYN_RS13005	COG3608	succinylglutamate desuccinylase aspartoacylase
SYN_RS13005	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SYN_RS13020	COG4772	TonB-dependent receptor
SYN_RS13030	COG0500	methyltransferase
SYN_RS13035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYN_RS13040	COG0848	biopolymer transport protein
SYN_RS13045	COG0811	peptide transport
SYN_RS13050	COG1120	ATPase activity
SYN_RS13055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SYN_RS13060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYN_RS13065	COG2226	methyltransferase
SYN_RS13095	COG2885	chlorophyll binding
SYN_RS13095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SYN_RS13105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SYN_RS13120	COG1640	4-alpha-glucanotransferase
SYN_RS13125	COG1104	cysteine desulfurase activity
SYN_RS13130	COG0425	Belongs to the sulfur carrier protein TusA family
SYN_RS13165	COG3263	regulation of cellular component size
SYN_RS13175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SYN_RS13175	COG4651	solute:proton antiporter activity
SYN_RS13190	COG1215	transferase activity, transferring glycosyl groups
SYN_RS13195	COG0463	Glycosyl transferase, family 2
SYN_RS13200	COG2379	hydroxypyruvate reductase
SYN_RS13205	COG3769	mannosylglycerate metabolic process
SYN_RS13230	COG2951	lytic endotransglycosylase activity
SYN_RS13235	COG0668	transmembrane transport
SYN_RS13245	COG0668	transmembrane transport
SYN_RS13250	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SYN_RS13260	COG0438	transferase activity, transferring glycosyl groups
SYN_RS13275	COG0739	heme binding
SYN_RS13300	COG0569	domain protein
SYN_RS13305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SYN_RS13310	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SYN_RS13320	COG1151	hydroxylamine reductase activity
SYN_RS13345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_RS13350	COG1131	(ABC) transporter
SYN_RS13355	COG1131	(ABC) transporter
SYN_RS13360	COG0842	Transport permease protein
SYN_RS13365	COG0842	Transport permease protein
SYN_RS13400	COG1278	Cold shock
SYN_RS13405	COG0513	Belongs to the DEAD box helicase family
SYN_RS13445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYN_RS13445	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SYN_RS13455	COG2181	nitrate reductase activity
SYN_RS13455	COG0247	lactate metabolic process
SYN_RS13480	COG1309	transcriptional regulator
SYN_RS13540	COG0729	surface antigen
SYN_RS13555	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SYN_RS13560	COG1169	isochorismate synthase
SYN_RS13570	COG0753	catalase activity
SYN_RS13575	COG1968	undecaprenyl-diphosphatase activity
SYN_RS13590	COG0463	Glycosyl transferase, family 2
SYN_RS13625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYN_RS13665	COG2226	methyltransferase
SYN_RS13670	COG1924	4 iron, 4 sulfur cluster binding
SYN_RS13675	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SYN_RS13680	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SYN_RS13685	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SYN_RS13695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYN_RS13710	COG0398	Pfam SNARE associated Golgi protein
SYN_RS13725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYN_RS13775	COG0640	Transcriptional regulator
SYN_RS13805	COG0798	PFAM Bile acid sodium symporter
SYN_RS13845	COG0519	Catalyzes the synthesis of GMP from XMP
SYN_RS13850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYN_RS13860	COG0456	acetyltransferase
SYN_RS13865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SYN_RS13875	COG0517	IMP dehydrogenase activity
SYN_RS13875	COG1994	Peptidase M50
SYN_RS13895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_RS13905	COG0277	FAD linked oxidase domain protein
SYN_RS13915	COG0589	response to stress
SYN_RS13925	COG0546	phosphoglycolate phosphatase activity
SYN_RS13930	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYN_RS13935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYN_RS13940	COG0154	amidase activity
SYN_RS13945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYN_RS13950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYN_RS13955	COG0805	protein transport
SYN_RS13965	COG0028	Belongs to the TPP enzyme family
SYN_RS13975	COG0028	Belongs to the TPP enzyme family
SYN_RS13985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SYN_RS13990	COG0129	dihydroxy-acid dehydratase activity
SYN_RS13995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYN_RS14000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SYN_RS14010	COG2204	response regulator
SYN_RS14020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SYN_RS14035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYN_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
SYN_RS14045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYN_RS14050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYN_RS14055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYN_RS14085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SYN_RS14090	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SYN_RS14095	COG0107	imidazoleglycerol-phosphate synthase activity
SYN_RS14115	COG1028	Short-chain dehydrogenase reductase Sdr
SYN_RS14130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SYN_RS14135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SYN_RS14140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SYN_RS14165	COG1131	(ABC) transporter
SYN_RS14170	COG0842	Transport permease protein
SYN_RS14175	COG4656	Part of a membrane complex involved in electron transport
SYN_RS14180	COG4658	electron transport chain
SYN_RS14185	COG4659	FMN binding
SYN_RS14190	COG4660	Part of a membrane complex involved in electron transport
SYN_RS14215	COG1024	Enoyl-CoA hydratase
SYN_RS14220	COG1024	Enoyl-CoA hydratase
SYN_RS14225	COG0006	proline dipeptidase activity
SYN_RS14230	COG1242	4 iron, 4 sulfur cluster binding
SYN_RS14235	COG0445	tRNA wobble uridine modification
SYN_RS14240	COG1034	ATP synthesis coupled electron transport
SYN_RS14270	COG0247	lactate metabolic process
SYN_RS14270	COG2181	nitrate reductase activity
SYN_RS14280	COG2414	aldehyde ferredoxin oxidoreductase
SYN_RS14290	COG1021	2,3-dihydroxybenzoate-AMP ligase
SYN_RS14300	COG5002	protein histidine kinase activity
SYN_RS14305	COG2204	response regulator
SYN_RS14325	COG0493	'glutamate synthase
SYN_RS14325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN_RS14330	COG0174	glutamine synthetase
SYN_RS14335	COG0505	Belongs to the CarA family
SYN_RS14340	COG0519	Catalyzes the synthesis of GMP from XMP
SYN_RS14340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SYN_RS14345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYN_RS14350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYN_RS14365	COG1408	metallophosphoesterase
SYN_RS14410	COG2249	NAD(P)H dehydrogenase (quinone) activity
SYN_RS14415	COG1024	Enoyl-CoA hydratase
SYN_RS14465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SYN_RS14470	COG0116	Belongs to the methyltransferase superfamily
SYN_RS14470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SYN_RS14485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SYN_RS14490	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SYN_RS14505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYN_RS14510	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SYN_RS14510	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SYN_RS14515	COG1268	BioY protein
SYN_RS14520	COG1122	ATPase activity
SYN_RS14525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SYN_RS14575	COG1278	Cold shock
SYN_RS14585	COG1605	Chorismate mutase
SYN_RS14585	COG0077	Prephenate dehydratase
SYN_RS14590	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SYN_RS14620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYN_RS14625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYN_RS14635	COG0356	it plays a direct role in the translocation of protons across the membrane
SYN_RS14690	COG3118	belongs to the thioredoxin family
SYN_RS14710	COG2814	Major facilitator Superfamily
SYN_RS14725	COG0280	phosphate acetyltransferase
SYN_RS14730	COG0280	phosphate acetyltransferase
SYN_RS14740	COG1489	DNA binding
SYN_RS14745	COG1309	transcriptional regulator
SYN_RS14750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_RS14755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SYN_RS14770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYN_RS14775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYN_RS14785	COG3008	intermembrane lipid transfer
SYN_RS14785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SYN_RS14795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_RS14800	COG0842	Transport permease protein
SYN_RS14800	COG1129	ABC transporter
SYN_RS14805	COG0842	Transport permease protein
SYN_RS14830	COG0348	domain, Protein
SYN_RS14830	COG3901	Regulator of nitric oxide reductase transcription
SYN_RS14835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SYN_RS14840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYN_RS14850	COG0357	Ribosomal RNA small subunit methyltransferase G
SYN_RS14855	COG1192	Involved in chromosome partitioning
SYN_RS14870	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SYN_RS14890	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SYN_RS14900	COG1399	metal-binding, possibly nucleic acid-binding protein
SYN_RS14910	COG4585	Histidine kinase
SYN_RS14930	COG1127	ABC transporter
SYN_RS14935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SYN_RS14950	COG1216	Glycosyl transferase, family 2
SYN_RS14955	COG1216	Glycosyl transferase, family 2
SYN_RS14955	COG1442	glycosyl transferase family 8
SYN_RS15020	COG3716	PTS system mannose fructose sorbose family IID component
SYN_RS15025	COG0840	transmembrane signaling receptor activity
SYN_RS15030	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SYN_RS15050	COG3604	Transcriptional regulator
SYN_RS15065	COG4585	Histidine kinase
SYN_RS15095	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYN_RS15095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYN_RS15115	COG2199	diguanylate cyclase activity
SYN_RS15115	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SYN_RS15120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SYN_RS15155	COG1847	R3H domain protein
SYN_RS15170	COG3290	protein histidine kinase activity
SYN_RS15170	COG0840	transmembrane signaling receptor activity
SYN_RS15205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SYN_RS15215	COG1419	protein localization to endoplasmic reticulum
SYN_RS15225	COG0457	Tetratricopeptide repeat
SYN_RS15225	COG0463	Glycosyl transferase, family 2
SYN_RS15230	COG2226	methyltransferase
SYN_RS15235	COG2199	diguanylate cyclase activity
SYN_RS15235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SYN_RS15250	COG5002	protein histidine kinase activity
SYN_RS15270	COG4589	Belongs to the CDS family
SYN_RS15320	COG5002	protein histidine kinase activity
SYN_RS15330	COG0360	Binds together with S18 to 16S ribosomal RNA
SYN_RS15335	COG3604	Transcriptional regulator
SYN_RS15340	COG0741	lytic transglycosylase activity
SYN_RS15390	COG4969	Belongs to the N-Me-Phe pilin family
SYN_RS15415	COG0840	transmembrane signaling receptor activity
SYN_RS15450	COG1215	transferase activity, transferring glycosyl groups
SYN_RS15470	COG0242	peptide deformylase activity
SYN_RS15475	COG3058	Necessary for formate dehydrogenase activity
SYN_RS15490	COG2205	protein histidine kinase activity
SYN_RS15490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYN_RS15535	COG3852	Histidine kinase
SYN_RS15550	COG4657	Part of a membrane complex involved in electron transport
SYN_RS15580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex