locus-tag	class	description
FBF38_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FBF38_RS00010	COG0592	DNA-directed DNA polymerase activity
FBF38_RS00110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FBF38_RS00115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FBF38_RS00155	COG0525	valine-tRNA ligase activity
FBF38_RS00165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FBF38_RS00170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FBF38_RS00175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FBF38_RS00185	COG0459	protein refolding
FBF38_RS00195	COG2222	sugar isomerase
FBF38_RS00200	COG0577	efflux transmembrane transporter activity
FBF38_RS00205	COG0577	efflux transmembrane transporter activity
FBF38_RS00205	COG1136	(ABC) transporter
FBF38_RS00225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FBF38_RS00235	COG0018	arginyl-trna synthetase
FBF38_RS00250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FBF38_RS00255	COG2315	Protein conserved in bacteria
FBF38_RS00265	COG0358	DNA primase activity
FBF38_RS00270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FBF38_RS00285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FBF38_RS00285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FBF38_RS00295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FBF38_RS00305	COG0268	Binds directly to 16S ribosomal RNA
FBF38_RS00315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FBF38_RS00320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FBF38_RS00330	COG1185	polyribonucleotide nucleotidyltransferase activity
FBF38_RS00345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FBF38_RS00360	COG0360	Binds together with S18 to 16S ribosomal RNA
FBF38_RS00370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FBF38_RS00380	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FBF38_RS00385	COG0012	GTP binding
FBF38_RS00415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FBF38_RS00425	COG1459	type II secretion system
FBF38_RS00460	COG4974	Belongs to the 'phage' integrase family
FBF38_RS00465	COG0105	UTP biosynthetic process
FBF38_RS00505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FBF38_RS00510	COG3695	enzyme binding
FBF38_RS00515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FBF38_RS00530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FBF38_RS00535	COG1994	Peptidase M50
FBF38_RS00545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FBF38_RS00555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FBF38_RS00560	COG0606	chelatase, subunit chli
FBF38_RS00590	COG0187	DNA topoisomerase II activity
FBF38_RS00595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FBF38_RS00630	COG0167	dihydroorotate dehydrogenase activity
FBF38_RS00665	COG1940	carbohydrate kinase activity
FBF38_RS00675	COG0539	negative regulation of cytoplasmic translation
FBF38_RS00680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FBF38_RS00700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FBF38_RS00705	COG0242	peptide deformylase activity
FBF38_RS00710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FBF38_RS00730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FBF38_RS00730	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FBF38_RS00750	COG0563	adenylate kinase activity
FBF38_RS00755	COG0024	Methionine aminopeptidase
FBF38_RS00770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FBF38_RS00775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FBF38_RS00820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FBF38_RS00825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FBF38_RS00830	COG1192	Involved in chromosome partitioning
FBF38_RS00835	COG1475	DNA binding
FBF38_RS00870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FBF38_RS00875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FBF38_RS00880	COG0254	rRNA binding
FBF38_RS00890	COG0052	Belongs to the universal ribosomal protein uS2 family
FBF38_RS00895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FBF38_RS00900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FBF38_RS00905	COG0233	cytoplasmic translational termination
FBF38_RS00915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FBF38_RS00920	COG0750	zinc metalloprotease
FBF38_RS00925	COG1266	CAAX protease self-immunity
FBF38_RS00930	COG0442	prolyl-tRNA aminoacylation
FBF38_RS00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FBF38_RS00940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FBF38_RS00950	COG4536	flavin adenine dinucleotide binding
FBF38_RS00960	COG0577	efflux transmembrane transporter activity
FBF38_RS00960	COG1136	(ABC) transporter
FBF38_RS00965	COG1136	(ABC) transporter
FBF38_RS00980	COG1968	undecaprenyl-diphosphatase activity
FBF38_RS00985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FBF38_RS00990	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FBF38_RS00995	COG0653	protein targeting
FBF38_RS01010	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FBF38_RS01015	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FBF38_RS01020	COG2884	Cell division ATP-binding protein ftsE
FBF38_RS01025	COG2177	Part of the ABC transporter FtsEX involved in
FBF38_RS01040	COG0745	RESPONSE REGULATOR receiver
FBF38_RS01065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FBF38_RS01080	COG1570	exodeoxyribonuclease VII activity
FBF38_RS01100	COG0745	RESPONSE REGULATOR receiver
FBF38_RS01105	COG1381	Involved in DNA repair and RecF pathway recombination
FBF38_RS01110	COG0423	glycine-tRNA ligase activity
FBF38_RS01145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FBF38_RS01150	COG0328	RNA-DNA hybrid ribonuclease activity
FBF38_RS01160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FBF38_RS01165	COG2001	Belongs to the MraZ family
FBF38_RS01170	COG0275	rRNA processing
FBF38_RS01180	COG0768	penicillin binding
FBF38_RS01185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FBF38_RS01190	COG0772	Belongs to the SEDS family
FBF38_RS01195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FBF38_RS01220	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FBF38_RS01230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FBF38_RS01245	COG0758	DNA mediated transformation
FBF38_RS01260	COG0701	Predicted permease
FBF38_RS01285	COG1160	GTP binding
FBF38_RS01295	COG1187	pseudouridine synthase activity
FBF38_RS01300	COG0745	RESPONSE REGULATOR receiver
FBF38_RS01325	COG0745	RESPONSE REGULATOR receiver
FBF38_RS01330	COG5002	protein histidine kinase activity
FBF38_RS01335	COG1470	cell adhesion involved in biofilm formation
FBF38_RS01370	COG0708	Exodeoxyribonuclease III
FBF38_RS01380	COG0438	transferase activity, transferring glycosyl groups
FBF38_RS01400	COG0488	(ABC) transporter
FBF38_RS01420	COG0356	it plays a direct role in the translocation of protons across the membrane
FBF38_RS01430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FBF38_RS01435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FBF38_RS01440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FBF38_RS01445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FBF38_RS01450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FBF38_RS01470	COG0210	DNA helicase
FBF38_RS01490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FBF38_RS01505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FBF38_RS01510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FBF38_RS01515	COG5002	protein histidine kinase activity
FBF38_RS01520	COG0745	RESPONSE REGULATOR receiver
FBF38_RS01525	COG4152	abc transporter atp-binding protein
FBF38_RS01535	COG0628	permease
FBF38_RS01540	COG0215	cysteine-tRNA ligase activity
FBF38_RS01560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FBF38_RS01565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FBF38_RS01575	COG0305	Participates in initiation and elongation during chromosome replication
FBF38_RS01580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FBF38_RS01600	COG0222	ribosome binding
FBF38_RS01605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FBF38_RS01620	COG0081	regulation of translation
FBF38_RS01630	COG0148	phosphopyruvate hydratase activity
FBF38_RS01635	COG0009	L-threonylcarbamoyladenylate synthase
FBF38_RS01640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FBF38_RS01645	COG0250	Participates in transcription elongation, termination and antitermination
FBF38_RS01650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FBF38_RS01655	COG5002	protein histidine kinase activity
FBF38_RS01675	COG0438	transferase activity, transferring glycosyl groups
FBF38_RS01685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FBF38_RS01695	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
FBF38_RS01710	COG4974	Belongs to the 'phage' integrase family
FBF38_RS01745	COG0470	DNA polymerase III
FBF38_RS01750	COG0564	pseudouridine synthase activity
FBF38_RS01780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FBF38_RS01785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FBF38_RS01790	COG0203	ribosomal protein L17
FBF38_RS01795	COG0202	RNA polymerase activity
FBF38_RS01800	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FBF38_RS01805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FBF38_RS01825	COG2217	Heavy metal translocating P-type atpase
FBF38_RS01830	COG3682	Transcriptional regulator
FBF38_RS01845	COG0200	Binds to the 23S rRNA
FBF38_RS01850	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FBF38_RS01855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FBF38_RS01860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FBF38_RS01870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FBF38_RS01890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FBF38_RS01895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FBF38_RS01900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FBF38_RS01905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FBF38_RS01910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FBF38_RS01915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FBF38_RS01920	COG0255	Belongs to the universal ribosomal protein uL29 family
FBF38_RS01925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FBF38_RS01930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FBF38_RS01935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FBF38_RS01940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FBF38_RS01945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FBF38_RS01950	COG0089	rRNA binding
FBF38_RS01955	COG0088	Forms part of the polypeptide exit tunnel
FBF38_RS01960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FBF38_RS01970	COG0051	transcription antitermination factor activity, RNA binding
FBF38_RS01975	COG0039	L-malate dehydrogenase activity
FBF38_RS01985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FBF38_RS01990	COG0343	queuine tRNA-ribosyltransferase activity
FBF38_RS02005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FBF38_RS02025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FBF38_RS02035	COG1666	GTP binding
FBF38_RS02040	COG0049	tRNA binding
FBF38_RS02045	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FBF38_RS02050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FBF38_RS02055	COG0085	RNA polymerase activity
FBF38_RS02065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FBF38_RS02080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FBF38_RS02085	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FBF38_RS02090	COG0740	serine-type endopeptidase activity
FBF38_RS02095	COG0544	peptidyl-prolyl cis-trans isomerase activity
FBF38_RS02130	COG0277	FAD linked oxidase domain protein
FBF38_RS02175	COG1217	gtp-binding protein TYPA
FBF38_RS02185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FBF38_RS02190	COG0330	HflC and HflK could
FBF38_RS02215	COG0366	Alpha amylase catalytic
FBF38_RS02220	COG0742	ribosomal rna small subunit methyltransferase
FBF38_RS02230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FBF38_RS02240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FBF38_RS02245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FBF38_RS02250	COG4956	integral membrane protein (PIN domain superfamily)
FBF38_RS02255	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FBF38_RS02275	COG0195	Participates in both transcription termination and antitermination
FBF38_RS02300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FBF38_RS02310	COG0335	large ribosomal subunit rRNA binding
FBF38_RS02315	COG0281	malic enzyme
FBF38_RS02325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FBF38_RS02350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FBF38_RS02355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FBF38_RS02365	COG0154	amidase activity
FBF38_RS02370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FBF38_RS02380	COG0556	nucleotide-excision repair
FBF38_RS02390	COG1611	Belongs to the LOG family
FBF38_RS02415	COG3959	Transketolase, thiamine diphosphate binding domain
FBF38_RS02420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FBF38_RS02425	COG0698	ribose 5-phosphate isomerase
FBF38_RS02430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FBF38_RS02445	COG0492	ferredoxin-NADP+ reductase activity
FBF38_RS02455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FBF38_RS02455	COG0072	phenylalanine-tRNA ligase activity
FBF38_RS02470	COG1136	(ABC) transporter
FBF38_RS02490	COG5002	protein histidine kinase activity
FBF38_RS02495	COG0745	RESPONSE REGULATOR receiver
FBF38_RS02510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FBF38_RS02525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FBF38_RS02550	COG0488	(ABC) transporter
FBF38_RS02555	COG0488	(ABC) transporter
FBF38_RS02565	COG0336	Belongs to the RNA methyltransferase TrmD family
FBF38_RS02580	COG1837	Belongs to the UPF0109 family
FBF38_RS02585	COG0571	ribonuclease III activity
FBF38_RS02605	COG0495	leucyl-tRNA aminoacylation
FBF38_RS02615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FBF38_RS02615	COG1181	Belongs to the D-alanine--D-alanine ligase family
FBF38_RS02635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FBF38_RS02650	COG1704	LemA family
FBF38_RS02685	COG1950	PFAM Membrane protein of
FBF38_RS02700	COG0662	Cupin 2, conserved barrel domain protein
FBF38_RS02705	COG3118	belongs to the thioredoxin family
FBF38_RS02715	COG1132	(ABC) transporter
FBF38_RS02720	COG0586	Pfam SNARE associated Golgi protein
FBF38_RS02725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FBF38_RS02740	COG2925	Exonuclease
FBF38_RS02745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FBF38_RS02750	COG3942	CHAP domain
FBF38_RS02750	COG1388	LysM domain
FBF38_RS02760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FBF38_RS02770	COG0849	cell division
FBF38_RS02780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FBF38_RS02790	COG0482	sulfurtransferase activity
FBF38_RS02815	COG0084	hydrolase, TatD family'
FBF38_RS02820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FBF38_RS02835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FBF38_RS02860	COG0149	triose-phosphate isomerase activity
FBF38_RS02870	COG0469	pyruvate kinase activity
FBF38_RS02885	COG5002	protein histidine kinase activity
FBF38_RS02895	COG2204	response regulator
FBF38_RS02900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FBF38_RS02935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FBF38_RS02940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FBF38_RS02975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FBF38_RS02995	COG0542	response to heat
FBF38_RS03005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FBF38_RS03040	COG0588	phosphoglycerate mutase activity
FBF38_RS03050	COG1418	mRNA catabolic process
FBF38_RS03060	COG1214	PFAM Peptidase M22, glycoprotease
FBF38_RS03065	COG0802	atpase or kinase
FBF38_RS03070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FBF38_RS03075	COG1459	type II secretion system
FBF38_RS03105	COG2137	regulation of response to DNA damage stimulus
FBF38_RS03115	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FBF38_RS03130	COG2255	four-way junction helicase activity
FBF38_RS03140	COG0632	four-way junction helicase activity
FBF38_RS03145	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FBF38_RS03155	COG0217	transcriptional regulatory protein
FBF38_RS03180	COG0189	ligase activity
FBF38_RS03190	COG0484	heat shock protein binding
FBF38_RS03200	COG0443	Heat shock 70 kDa protein
FBF38_RS03205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FBF38_RS03210	COG1420	regulation of RNA biosynthetic process
FBF38_RS03220	COG0194	GDP metabolic process
FBF38_RS03225	COG0481	GTPase activity
FBF38_RS03240	COG0481	GTPase activity
FBF38_RS03250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FBF38_RS03255	COG0037	tRNA processing
FBF38_RS03310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FBF38_RS03320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FBF38_RS03325	COG0668	transmembrane transport
FBF38_RS03360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FBF38_RS03375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FBF38_RS03375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FBF38_RS03390	COG0549	Belongs to the carbamate kinase family
FBF38_RS03395	COG1288	antiporter activity
FBF38_RS03400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FBF38_RS03405	COG2235	arginine
FBF38_RS03420	COG1132	(ABC) transporter
FBF38_RS03435	COG0494	nUDIX hydrolase
FBF38_RS03445	COG0765	amino acid transport
FBF38_RS03450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FBF38_RS03460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FBF38_RS03465	COG0542	response to heat
FBF38_RS03500	COG0726	polysaccharide deacetylase
FBF38_RS03505	COG1872	DUF167
FBF38_RS03510	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FBF38_RS03555	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FBF38_RS03560	COG2003	Belongs to the UPF0758 family
FBF38_RS03570	COG1017	nitric oxide dioxygenase activity
FBF38_RS03570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FBF38_RS03580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FBF38_RS03580	COG1328	CTP reductase activity
FBF38_RS03610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FBF38_RS03625	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FBF38_RS03625	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FBF38_RS03630	COG1088	dTDP-glucose 4,6-dehydratase activity
FBF38_RS03640	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FBF38_RS03645	COG0463	Glycosyl transferase, family 2
FBF38_RS03700	COG0438	transferase activity, transferring glycosyl groups
FBF38_RS03700	COG1216	Glycosyl transferase, family 2
FBF38_RS03720	COG0463	Glycosyl transferase, family 2
FBF38_RS03735	COG0706	membrane insertase activity
FBF38_RS03745	COG0230	Belongs to the bacterial ribosomal protein bL34 family