locus-tag	class	description
FBF37_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FBF37_RS00010	COG0592	DNA-directed DNA polymerase activity
FBF37_RS00090	COG0071	Belongs to the small heat shock protein (HSP20) family
FBF37_RS00095	COG1040	competence protein
FBF37_RS00100	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FBF37_RS00145	COG0525	valine-tRNA ligase activity
FBF37_RS00150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FBF37_RS00155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FBF37_RS00160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FBF37_RS00165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FBF37_RS00170	COG0459	protein refolding
FBF37_RS00180	COG2222	sugar isomerase
FBF37_RS00185	COG0577	efflux transmembrane transporter activity
FBF37_RS00190	COG1136	(ABC) transporter
FBF37_RS00205	COG0590	tRNA wobble adenosine to inosine editing
FBF37_RS00215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FBF37_RS00230	COG0018	arginyl-trna synthetase
FBF37_RS00250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FBF37_RS00255	COG2315	Protein conserved in bacteria
FBF37_RS00265	COG0358	DNA primase activity
FBF37_RS00265	COG0305	Participates in initiation and elongation during chromosome replication
FBF37_RS00270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FBF37_RS00280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FBF37_RS00280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FBF37_RS00295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FBF37_RS00315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FBF37_RS00325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FBF37_RS00335	COG1185	polyribonucleotide nucleotidyltransferase activity
FBF37_RS00345	COG1959	2 iron, 2 sulfur cluster binding
FBF37_RS00350	COG1511	domain protein
FBF37_RS00355	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FBF37_RS00370	COG0360	Binds together with S18 to 16S ribosomal RNA
FBF37_RS00375	COG0629	single-stranded DNA binding
FBF37_RS00380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FBF37_RS00395	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FBF37_RS00400	COG0012	GTP binding
FBF37_RS00435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FBF37_RS00445	COG1459	type II secretion system
FBF37_RS00480	COG4974	Belongs to the 'phage' integrase family
FBF37_RS00485	COG0105	UTP biosynthetic process
FBF37_RS00525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FBF37_RS00530	COG3695	enzyme binding
FBF37_RS00535	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FBF37_RS00550	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FBF37_RS00555	COG1994	Peptidase M50
FBF37_RS00565	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FBF37_RS00575	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FBF37_RS00580	COG0606	chelatase, subunit chli
FBF37_RS00615	COG0187	DNA topoisomerase II activity
FBF37_RS00620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FBF37_RS00655	COG0167	dihydroorotate dehydrogenase activity
FBF37_RS00685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FBF37_RS00685	COG3064	Membrane
FBF37_RS00710	COG0242	peptide deformylase activity
FBF37_RS00715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FBF37_RS00730	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FBF37_RS00730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FBF37_RS00750	COG0563	adenylate kinase activity
FBF37_RS00755	COG0024	Methionine aminopeptidase
FBF37_RS00770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FBF37_RS00775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FBF37_RS00800	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FBF37_RS00800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FBF37_RS00805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FBF37_RS00820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FBF37_RS00825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FBF37_RS00830	COG1192	Involved in chromosome partitioning
FBF37_RS00835	COG1475	DNA binding
FBF37_RS00850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FBF37_RS00855	COG2890	protein-(glutamine-N5) methyltransferase activity
FBF37_RS00865	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FBF37_RS00875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FBF37_RS00885	COG0254	rRNA binding
FBF37_RS00890	COG0052	Belongs to the universal ribosomal protein uS2 family
FBF37_RS00905	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FBF37_RS00910	COG0233	cytoplasmic translational termination
FBF37_RS00915	COG0142	geranyltranstransferase activity
FBF37_RS00920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FBF37_RS00925	COG0750	zinc metalloprotease
FBF37_RS00935	COG0442	prolyl-tRNA aminoacylation
FBF37_RS00945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FBF37_RS00955	COG4535	Mg2 and Co2 transporter CorC
FBF37_RS00965	COG1136	(ABC) transporter
FBF37_RS00965	COG0577	efflux transmembrane transporter activity
FBF37_RS00970	COG1136	(ABC) transporter
FBF37_RS00975	COG1695	Transcriptional regulator
FBF37_RS00985	COG1968	undecaprenyl-diphosphatase activity
FBF37_RS00990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FBF37_RS00995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FBF37_RS01010	COG0714	Associated with various cellular activities
FBF37_RS01020	COG0653	protein targeting
FBF37_RS01030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FBF37_RS01035	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FBF37_RS01045	COG2884	Cell division ATP-binding protein ftsE
FBF37_RS01050	COG2177	Part of the ABC transporter FtsEX involved in
FBF37_RS01055	COG3942	CHAP domain
FBF37_RS01060	COG3409	Peptidoglycan-binding domain 1 protein
FBF37_RS01060	COG0793	Belongs to the peptidase S41A family
FBF37_RS01065	COG0745	RESPONSE REGULATOR receiver
FBF37_RS01070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FBF37_RS01075	COG0116	Belongs to the methyltransferase superfamily
FBF37_RS01075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FBF37_RS01085	COG1570	exodeoxyribonuclease VII activity
FBF37_RS01095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FBF37_RS01115	COG1381	Involved in DNA repair and RecF pathway recombination
FBF37_RS01120	COG0423	glycine-tRNA ligase activity
FBF37_RS01160	COG0328	RNA-DNA hybrid ribonuclease activity
FBF37_RS01175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FBF37_RS01180	COG2723	6-phospho-beta-galactosidase activity
FBF37_RS01185	COG2001	Belongs to the MraZ family
FBF37_RS01190	COG0275	rRNA processing
FBF37_RS01205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FBF37_RS01210	COG0772	Belongs to the SEDS family
FBF37_RS01215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FBF37_RS01280	COG1876	peptidase activity
FBF37_RS01295	COG0708	Exodeoxyribonuclease III
FBF37_RS01300	COG0528	UMP kinase activity
FBF37_RS01325	COG0488	(ABC) transporter
FBF37_RS01370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FBF37_RS01375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FBF37_RS01385	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FBF37_RS01390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FBF37_RS01400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FBF37_RS01410	COG0210	DNA helicase
FBF37_RS01425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FBF37_RS01430	COG2165	general secretion pathway protein
FBF37_RS01460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FBF37_RS01465	COG5002	protein histidine kinase activity
FBF37_RS01470	COG0745	RESPONSE REGULATOR receiver
FBF37_RS01475	COG4152	abc transporter atp-binding protein
FBF37_RS01485	COG0628	permease
FBF37_RS01490	COG0215	cysteine-tRNA ligase activity
FBF37_RS01540	COG0758	DNA mediated transformation
FBF37_RS01555	COG0523	cobalamin synthesis protein
FBF37_RS01585	COG1160	GTP binding
FBF37_RS01600	COG0745	RESPONSE REGULATOR receiver
FBF37_RS01605	COG5002	protein histidine kinase activity
FBF37_RS01615	COG0745	RESPONSE REGULATOR receiver
FBF37_RS01620	COG2205	protein histidine kinase activity
FBF37_RS01625	COG1470	cell adhesion involved in biofilm formation
FBF37_RS01630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FBF37_RS01635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FBF37_RS01645	COG0305	Participates in initiation and elongation during chromosome replication
FBF37_RS01650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FBF37_RS01675	COG0222	ribosome binding
FBF37_RS01680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FBF37_RS01705	COG0148	phosphopyruvate hydratase activity
FBF37_RS01710	COG0009	L-threonylcarbamoyladenylate synthase
FBF37_RS01720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FBF37_RS01735	COG0250	Participates in transcription elongation, termination and antitermination
FBF37_RS01745	COG5002	protein histidine kinase activity
FBF37_RS01765	COG0438	transferase activity, transferring glycosyl groups
FBF37_RS01775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FBF37_RS01785	COG1666	GTP binding
FBF37_RS01815	COG0470	DNA polymerase III
FBF37_RS01820	COG0564	pseudouridine synthase activity
FBF37_RS01825	COG0180	Tryptophanyl-tRNA synthetase
FBF37_RS01840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FBF37_RS01845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FBF37_RS01850	COG0203	ribosomal protein L17
FBF37_RS01860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FBF37_RS01865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FBF37_RS01880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FBF37_RS01890	COG3682	Transcriptional regulator
FBF37_RS01905	COG0200	Binds to the 23S rRNA
FBF37_RS01910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FBF37_RS01915	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FBF37_RS01920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FBF37_RS01935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FBF37_RS01940	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FBF37_RS01945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FBF37_RS01950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FBF37_RS01955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FBF37_RS01960	COG0255	Belongs to the universal ribosomal protein uL29 family
FBF37_RS01965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FBF37_RS01970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FBF37_RS01975	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FBF37_RS01980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FBF37_RS01985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FBF37_RS01990	COG0089	rRNA binding
FBF37_RS01995	COG0088	Forms part of the polypeptide exit tunnel
FBF37_RS02000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FBF37_RS02010	COG0051	transcription antitermination factor activity, RNA binding
FBF37_RS02015	COG0039	L-malate dehydrogenase activity
FBF37_RS02060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FBF37_RS02070	COG0049	tRNA binding
FBF37_RS02075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FBF37_RS02085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FBF37_RS02090	COG0085	RNA polymerase activity
FBF37_RS02095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FBF37_RS02130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FBF37_RS02140	COG0544	peptidyl-prolyl cis-trans isomerase activity
FBF37_RS02200	COG0277	FAD linked oxidase domain protein
FBF37_RS02205	COG4974	Belongs to the 'phage' integrase family
FBF37_RS02255	COG1217	gtp-binding protein TYPA
FBF37_RS02265	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FBF37_RS02270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FBF37_RS02280	COG0366	Alpha amylase catalytic
FBF37_RS02310	COG0742	ribosomal rna small subunit methyltransferase
FBF37_RS02320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FBF37_RS02330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FBF37_RS02335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FBF37_RS02340	COG4956	integral membrane protein (PIN domain superfamily)
FBF37_RS02345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FBF37_RS02355	COG0542	response to heat
FBF37_RS02360	COG0542	response to heat
FBF37_RS02365	COG0195	Participates in both transcription termination and antitermination
FBF37_RS02395	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FBF37_RS02410	COG0335	large ribosomal subunit rRNA binding
FBF37_RS02425	COG0281	malic enzyme
FBF37_RS02430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FBF37_RS02435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FBF37_RS02455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FBF37_RS02460	COG1618	nucleotide phosphatase activity, acting on free nucleotides
FBF37_RS02465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FBF37_RS02475	COG0154	amidase activity
FBF37_RS02480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FBF37_RS02490	COG0556	nucleotide-excision repair
FBF37_RS02495	COG0137	argininosuccinate synthase activity
FBF37_RS02500	COG0165	Argininosuccinate lyase
FBF37_RS02505	COG1611	Belongs to the LOG family
FBF37_RS02515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FBF37_RS02525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FBF37_RS02530	COG3959	Transketolase, thiamine diphosphate binding domain
FBF37_RS02535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FBF37_RS02540	COG0698	ribose 5-phosphate isomerase
FBF37_RS02570	COG1132	(ABC) transporter
FBF37_RS02575	COG0072	phenylalanine-tRNA ligase activity
FBF37_RS02575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FBF37_RS02605	COG1136	(ABC) transporter
FBF37_RS02645	COG0456	acetyltransferase
FBF37_RS02645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FBF37_RS02650	COG5002	protein histidine kinase activity
FBF37_RS02655	COG0745	RESPONSE REGULATOR receiver
FBF37_RS02670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FBF37_RS02675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FBF37_RS02690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FBF37_RS02720	COG0336	Belongs to the RNA methyltransferase TrmD family
FBF37_RS02730	COG1837	Belongs to the UPF0109 family
FBF37_RS02735	COG0571	ribonuclease III activity
FBF37_RS02755	COG0495	leucyl-tRNA aminoacylation
FBF37_RS02765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FBF37_RS02790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FBF37_RS02800	COG0501	Belongs to the peptidase M48B family
FBF37_RS02805	COG1704	LemA family
FBF37_RS02810	COG4221	oxidoreductase activity
FBF37_RS02845	COG1950	PFAM Membrane protein of
FBF37_RS02855	COG0322	excinuclease ABC activity
FBF37_RS02870	COG3118	belongs to the thioredoxin family
FBF37_RS02880	COG1132	(ABC) transporter
FBF37_RS02890	COG0586	Pfam SNARE associated Golgi protein
FBF37_RS02895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FBF37_RS02905	COG2925	Exonuclease
FBF37_RS02915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FBF37_RS02920	COG3942	CHAP domain
FBF37_RS02930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FBF37_RS02940	COG0849	cell division
FBF37_RS02945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FBF37_RS02950	COG0228	four-way junction DNA binding
FBF37_RS02955	COG0482	sulfurtransferase activity
FBF37_RS02965	COG1104	cysteine desulfurase activity
FBF37_RS02980	COG0084	hydrolase, TatD family'
FBF37_RS02985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FBF37_RS03020	COG0149	triose-phosphate isomerase activity
FBF37_RS03025	COG0126	phosphoglycerate kinase activity
FBF37_RS03030	COG0469	pyruvate kinase activity
FBF37_RS03035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FBF37_RS03070	COG5002	protein histidine kinase activity
FBF37_RS03075	COG2204	response regulator
FBF37_RS03080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FBF37_RS03110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FBF37_RS03115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FBF37_RS03140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FBF37_RS03155	COG0542	response to heat
FBF37_RS03180	COG0588	phosphoglycerate mutase activity
FBF37_RS03185	COG1418	mRNA catabolic process
FBF37_RS03190	COG1214	PFAM Peptidase M22, glycoprotease
FBF37_RS03195	COG0802	atpase or kinase
FBF37_RS03200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FBF37_RS03205	COG1459	type II secretion system
FBF37_RS03235	COG2137	regulation of response to DNA damage stimulus
FBF37_RS03245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FBF37_RS03260	COG2255	four-way junction helicase activity
FBF37_RS03275	COG0632	four-way junction helicase activity
FBF37_RS03280	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FBF37_RS03290	COG0217	transcriptional regulatory protein
FBF37_RS03325	COG0484	heat shock protein binding
FBF37_RS03340	COG0443	Heat shock 70 kDa protein
FBF37_RS03350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FBF37_RS03355	COG1420	regulation of RNA biosynthetic process
FBF37_RS03365	COG0194	GDP metabolic process
FBF37_RS03385	COG0481	GTPase activity
FBF37_RS03400	COG0481	GTPase activity
FBF37_RS03410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FBF37_RS03415	COG0037	tRNA processing
FBF37_RS03485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FBF37_RS03490	COG0668	transmembrane transport
FBF37_RS03515	COG1194	a g-specific adenine glycosylase
FBF37_RS03530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FBF37_RS03545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FBF37_RS03555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FBF37_RS03555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FBF37_RS03570	COG1131	(ABC) transporter
FBF37_RS03575	COG0598	Magnesium transport protein CorA
FBF37_RS03580	COG0549	Belongs to the carbamate kinase family
FBF37_RS03585	COG1288	antiporter activity
FBF37_RS03610	COG1881	PFAM PEBP family protein
FBF37_RS03620	COG1132	(ABC) transporter
FBF37_RS03635	COG0494	nUDIX hydrolase
FBF37_RS03655	COG0765	amino acid transport
FBF37_RS03660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FBF37_RS03670	COG0542	response to heat
FBF37_RS03680	COG1136	(ABC) transporter
FBF37_RS03700	COG0726	polysaccharide deacetylase
FBF37_RS03705	COG1872	DUF167
FBF37_RS03745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FBF37_RS03750	COG2003	Belongs to the UPF0758 family
FBF37_RS03755	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FBF37_RS03805	COG1328	CTP reductase activity
FBF37_RS03805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FBF37_RS03825	COG1131	(ABC) transporter
FBF37_RS03830	COG5002	protein histidine kinase activity
FBF37_RS03830	COG3850	Histidine kinase
FBF37_RS03860	COG0701	Predicted permease
FBF37_RS03870	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FBF37_RS03900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FBF37_RS03905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FBF37_RS03925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FBF37_RS03935	COG1088	dTDP-glucose 4,6-dehydratase activity
FBF37_RS03940	COG0494	nUDIX hydrolase
FBF37_RS03960	COG0463	Glycosyl transferase, family 2
FBF37_RS04035	COG0706	membrane insertase activity
FBF37_RS04045	COG0230	Belongs to the bacterial ribosomal protein bL34 family