locus-tag class description EI545_RS00015 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EI545_RS00020 ENOG4108JQ7 (ABC) transporter EI545_RS00025 ENOG4105C3U ABC transporter EI545_RS00030 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EI545_RS00035 ENOG4108DN8 FAD dependent oxidoreductase EI545_RS00040 ENOG4105R8A Heat shock protein EI545_RS00045 ENOG4105CH2 amidohydrolase EI545_RS00050 ENOG4105CEY Amp-dependent synthetase and ligase EI545_RS00055 ENOG4105BZU Histidine kinase EI545_RS00070 ENOG4105CFF transcriptional regulator EI545_RS00085 ENOG4105CMV Succinyl-CoA synthetase subunit beta EI545_RS00090 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EI545_RS00095 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EI545_RS00100 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EI545_RS00110 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) EI545_RS00120 ENOG4108K5H permease YjgP YjgQ family protein EI545_RS00125 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EI545_RS00140 ENOG41081FY multiple antibiotic resistance (MarC)-related EI545_RS00145 ENOG4105C5H ABC transporter EI545_RS00150 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EI545_RS00155 ENOG4105DJV ribulose-phosphate 3-epimerase EI545_RS00160 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EI545_RS00170 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EI545_RS00190 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) EI545_RS00230 ENOG4107ZXU DSBA oxidoreductase EI545_RS00235 ENOG4105C2C drug resistance transporter, Bcr CflA EI545_RS00250 ENOG4105D52 delta-aminolevulinic acid dehydratase EI545_RS00260 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EI545_RS00265 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EI545_RS00270 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EI545_RS00285 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS00290 ENOG4105CG3 alpha amylase, catalytic region EI545_RS00295 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component EI545_RS00300 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component EI545_RS00305 ENOG4105EPJ extracellular solute-binding protein family 1 EI545_RS00310 ENOG4105FKQ transcriptional regulator EI545_RS00320 ENOG4105CHC glucokinase (EC 2.7.1.2) EI545_RS00325 ENOG4106KED esterase YpfH EI545_RS00335 ENOG4105DXI Major Facilitator superfamily EI545_RS00345 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EI545_RS00350 ENOG4105C8N cysteinyl-tRNA synthetase EI545_RS00360 ENOG4107SJ9 decarboxylase EI545_RS00365 ENOG4105HA9 of methanol dehydrogenase type EI545_RS00380 ENOG4105C5H ABC transporter EI545_RS00405 ENOG4106BM2 Cupin domain EI545_RS00445 ENOG4105M4H endoribonuclease L-psp EI545_RS00450 ENOG4107QP8 phosphohexose isomerase EI545_RS00460 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EI545_RS00500 ENOG4105F5V trimethylamine methyltransferase EI545_RS00505 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 EI545_RS00515 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) EI545_RS00520 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) EI545_RS00525 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) EI545_RS00530 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) EI545_RS00560 ENOG4105Y2X UPF0335 protein EI545_RS00570 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EI545_RS00580 ENOG4105NHS Transcriptional regulator, TraR DksA family EI545_RS00590 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EI545_RS00605 ENOG4108PYU two-component system response regulator EI545_RS00610 ENOG4105CFF transcriptional regulator EI545_RS00615 ENOG4107Z6I Thiamine biosynthesis protein EI545_RS00620 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EI545_RS00625 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EI545_RS00635 ENOG4108IY8 ABC, transporter EI545_RS00640 ENOG4105CD3 dihydroorotase EI545_RS00650 ENOG4105CE7 Amidase, hydantoinase carbamoylase family EI545_RS00655 ENOG4108R86 Transcriptional regulator EI545_RS00660 ENOG41090KN UPF0303 protein EI545_RS00665 ENOG4105K8K Cupin 2, conserved barrel EI545_RS00670 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EI545_RS00675 ENOG4108R86 Transcriptional regulator EI545_RS00685 ENOG4107SJI Dehydrogenase EI545_RS00695 ENOG4105BZ8 glutamate synthase EI545_RS00705 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EI545_RS00710 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) EI545_RS00735 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EI545_RS00750 ENOG4105E0F Histidine kinase EI545_RS00755 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EI545_RS00770 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EI545_RS00785 ENOG4105CYW agmatinase EI545_RS00800 ENOG4105CH2 amidohydrolase EI545_RS00805 ENOG4105DXN mazG family EI545_RS00820 ENOG4105DU0 nucleoside hydrolase EI545_RS00835 ENOG4105BZU Histidine kinase EI545_RS00845 ENOG4108Z0R Transferase EI545_RS00850 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EI545_RS00855 ENOG4105DSJ YicC domain protein EI545_RS00865 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase EI545_RS00870 ENOG4105ECQ AraC Family Transcriptional Regulator EI545_RS00875 ENOG4105D8V Glucose sorbosone dehydrogenase EI545_RS00880 ENOG4105CP9 extracellular ligand-binding receptor EI545_RS00885 ENOG4105C0Z ABC transporter EI545_RS00890 ENOG4108IV0 ABC, transporter EI545_RS00895 ENOG4105C32 Amino acid ABC transporter (Permease) EI545_RS00930 ENOG4105CGZ zinc metallopeptidase EI545_RS00940 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein EI545_RS00945 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EI545_RS00960 ENOG4105MSY salicylate hydroxylase EI545_RS00970 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EI545_RS00985 ENOG4108K0D peptidase, M48 EI545_RS00995 ENOG4105DR4 Methyltransferase EI545_RS01000 ENOG4105C01 Dihydroxy-acid dehydratase EI545_RS01005 ENOG4108UHU Aldolase EI545_RS01015 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) EI545_RS01030 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase EI545_RS01040 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EI545_RS01045 ENOG4105CH5 extracellular solute-binding protein, family 7 EI545_RS01060 ENOG4105C7K acetolactate synthase EI545_RS01080 ENOG4105CGU Enoyl-CoA hydratase EI545_RS01085 ENOG4105KWW Biogenesis protein EI545_RS01090 ENOG4105DA4 cytochrome c-type biogenesis protein EI545_RS01095 ENOG41066UZ arginase EC 3.5.3.1 EI545_RS01100 ENOG4107QWB Ornithine cyclodeaminase EI545_RS01105 ENOG4105P0T Usg family EI545_RS01115 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EI545_RS01130 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) EI545_RS01145 ENOG4105CB5 ATP-dependent DNA helicase recG EI545_RS01150 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EI545_RS01165 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EI545_RS01170 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EI545_RS01175 ENOG4105GYT Protein of unknown function (DUF1009) EI545_RS01180 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EI545_RS01195 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EI545_RS01200 ENOG4105DZP Membrane-associated zinc metalloprotease EI545_RS01205 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EI545_RS01210 ENOG4105KNE Phosphatidate cytidylyltransferase EI545_RS01215 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EI545_RS01220 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EI545_RS01230 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EI545_RS01250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EI545_RS01265 ENOG4108UUM single-stranded DNA-binding protein EI545_RS01270 ENOG4105VG1 fes assembly suf system protein EI545_RS01275 ENOG4108Z4V iron-sulfur cluster assembly EI545_RS01280 ENOG4105CP7 Triose-phosphate isomerase EI545_RS01295 ENOG4108XM1 transcriptional regulator AsnC family EI545_RS01300 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EI545_RS01310 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EI545_RS01315 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EI545_RS01325 ENOG4105DP0 ferredoxin-NADP reductase EI545_RS01335 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EI545_RS01345 ENOG4107XAN XdhC and CoxI family EI545_RS01350 ENOG4105KCK Peptidoglycan-associated lipoprotein EI545_RS01370 ENOG4105ETT transcriptional Regulator, LysR family EI545_RS01375 ENOG4105C1G acyl-Coa dehydrogenase EI545_RS01390 ENOG4105VTN Protein of unknown function (DUF1311) EI545_RS01400 ENOG4105EKE dihydroorotase EI545_RS01410 ENOG4105CDU Replicative dna helicase EI545_RS01415 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EI545_RS01420 ENOG4105C59 p-type ATPase EI545_RS01455 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EI545_RS01465 ENOG4105EMU Dehydrogenase EI545_RS01470 ENOG4105C28 cystathionine EI545_RS01525 ENOG4105C84 Histidine ammonia-lyase EI545_RS01530 ENOG4105CGP Urocanate hydratase EI545_RS01540 ENOG4105DCG PHP domain protein EI545_RS01545 ENOG4107YCR Transcriptional regulator, ARSR family EI545_RS01550 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EI545_RS01560 ENOG4105CC5 ABC transporter EI545_RS01565 ENOG4105CC5 ABC transporter EI545_RS01570 ENOG4105DIK (ABC) transporter EI545_RS01585 ENOG4105C9B Cysteine desulfurase EI545_RS01600 ENOG4105JRK feS assembly protein SufD EI545_RS01605 ENOG4105C3K feS assembly ATPase SufC EI545_RS01635 ENOG4105C3J Cysteine desulfurase EI545_RS01640 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family EI545_RS01645 ENOG4105DHZ alpha beta EI545_RS01685 ENOG4105CI3 gtp-binding protein typa EI545_RS01705 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EI545_RS01710 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EI545_RS01730 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EI545_RS01745 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EI545_RS01760 ENOG4105C1A potassium transporter peripheral membrane EI545_RS01765 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EI545_RS01770 ENOG4105ES5 Histidine kinase EI545_RS01780 ENOG4105CUX Signal transduction histidine kinase EI545_RS01785 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EI545_RS01790 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EI545_RS01800 ENOG4105CEV competence damage-inducible protein EI545_RS01810 ENOG4108Z1B Cyclase dehydrase EI545_RS01815 ENOG4108UGV hypoxanthine phosphoribosyltransferase EI545_RS01820 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding EI545_RS01895 ENOG4105CSR polyphosphate kinase 2 EI545_RS01910 ENOG4105D38 putrescine abc transporter EI545_RS01915 ENOG4105F38 ABC transporter, permease EI545_RS01925 ENOG4107SQD Transcriptional regulator, GntR family EI545_RS01935 ENOG4105EXC Acyl-transferase EI545_RS01945 ENOG4108UJD 30S ribosomal protein S9 EI545_RS01960 ENOG4108RG0 uracil-dna glycosylase EI545_RS01965 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EI545_RS01970 ENOG4105EY8 ABC transporter EI545_RS01975 ENOG4105ECX polysaccharide export EI545_RS01980 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EI545_RS01985 ENOG4105CBX hi0933 family EI545_RS02010 ENOG4105BZU Histidine kinase EI545_RS02015 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EI545_RS02035 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EI545_RS02045 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) EI545_RS02050 ENOG4105E89 ABC transporter EI545_RS02055 ENOG4105DSP amino acid AbC transporter EI545_RS02060 ENOG4106YG3 ABC transporter EI545_RS02070 ENOG4108JEH abc transporter atp-binding protein EI545_RS02080 ENOG4105KCV RNA signal recognition particle 4.5S RNA EI545_RS02090 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) EI545_RS02095 ENOG4105EHG Permease protein EI545_RS02100 ENOG4107R4I Periplasmic binding protein EI545_RS02110 ENOG4107ENK receptor EI545_RS02120 ENOG4108ZZF transport protein (ExbD) EI545_RS02130 ENOG4108N8X transition metal ion binding EI545_RS02165 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain EI545_RS02180 ENOG4105G2Y Transcriptional regulator EI545_RS02230 ENOG4105CEY Amp-dependent synthetase and ligase EI545_RS02240 ENOG4105CHP RNA polymerase EI545_RS02250 ENOG4108VQT Alpha beta hydrolase fold protein EI545_RS02260 ENOG4105MKU Transcriptional regulator EI545_RS02295 ENOG4108ES9 ParB domain protein nuclease EI545_RS02385 ENOG4105DZ1 carboxypeptidase EI545_RS02390 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EI545_RS02395 ENOG4107QRG dna polymerase iii EI545_RS02400 ENOG4105F8V Hydrolase, tatD family EI545_RS02405 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EI545_RS02415 ENOG4105D38 putrescine abc transporter EI545_RS02430 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS02445 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EI545_RS02455 ENOG4105BZ9 Cytochrome C oxidase, subunit I EI545_RS02485 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EI545_RS02520 ENOG4108ZRZ Transcriptional regulator (AsnC family) EI545_RS02540 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EI545_RS02555 ENOG4105F0V Cell wall hydrolase EI545_RS02560 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EI545_RS02565 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EI545_RS02575 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit EI545_RS02585 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) EI545_RS02590 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) EI545_RS02610 ENOG4107835 probably involved in intracellular septation (By similarity) EI545_RS02620 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EI545_RS02655 ENOG4107R7Y intracellular protease Pfpi family EI545_RS02665 ENOG4105C12 Phosphoribosylglycinamide synthetase EI545_RS02670 ENOG4105CFH Aspartokinase EI545_RS02675 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EI545_RS02680 ENOG4105CEY Amp-dependent synthetase and ligase EI545_RS02695 ENOG4107RT4 flavin reductase domain protein EI545_RS02705 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EI545_RS02715 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EI545_RS02725 ENOG4105E98 transcriptional regulator DeoR family EI545_RS02730 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EI545_RS02740 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EI545_RS02745 ENOG4105C7K acetolactate synthase EI545_RS02760 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EI545_RS02770 ENOG4108302 MgtC SapB transporter EI545_RS02780 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS02790 ENOG4105F38 ABC transporter, permease EI545_RS02795 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component EI545_RS02800 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr EI545_RS02820 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EI545_RS02850 ENOG4107QPD alcohol dehydrogenase EI545_RS02860 ENOG410810E transcriptional regulator, lysR family EI545_RS02880 ENOG4105C72 UPF0176 protein EI545_RS02885 ENOG4108RWI nicotinamidase EI545_RS02890 ENOG4107RH7 Nicotinate phosphoribosyltransferase EI545_RS02895 ENOG4105CUV Homoserine Kinase EI545_RS02900 ENOG4108YZN class I peptide chain release factor EI545_RS02905 ENOG4105EX9 Membrane EI545_RS02910 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) EI545_RS02930 ENOG4105C9U ATP-dependent DNA helicase RecQ EI545_RS02935 ENOG4105BZU Histidine kinase EI545_RS02940 ENOG4105DN3 alpha-2-macroglobulin domain protein EI545_RS02945 ENOG4108JQB penicillin-binding protein 1C EI545_RS02950 ENOG4105CHU acetyl-coa acetyltransferase EI545_RS02960 ENOG4108VRQ UPF0314 protein EI545_RS02970 ENOG4107S1Q Phosphatase EI545_RS02975 ENOG4108JQ1 Dehydrogenase EI545_RS02980 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EI545_RS02985 ENOG4105EAC phosphoserine phosphatase EI545_RS03005 ENOG4105D6Z AFG1 family ATPase EI545_RS03015 ENOG4105CV8 reductase EI545_RS03020 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS03025 ENOG4105D38 putrescine abc transporter EI545_RS03030 ENOG4105F38 ABC transporter, permease EI545_RS03045 ENOG4108KD5 ADP-ribosylation crystallin J1 EI545_RS03050 ENOG4107414 GntR family transcriptional regulator EI545_RS03055 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) EI545_RS03060 ENOG4105CVE Lytic murein transglycosylase EI545_RS03065 ENOG4105CVS RNA methyltransferase TrmH family, group 1 EI545_RS03100 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EI545_RS03160 ENOG4106KR7 LysR family Transcriptional regulator EI545_RS03165 ENOG410626B catechol 1,2-dioxygenase EI545_RS03190 ENOG4108IUZ ABC transporter EI545_RS03195 ENOG4108IV0 ABC, transporter EI545_RS03200 ENOG4105C32 Amino acid ABC transporter (Permease) EI545_RS03220 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme EI545_RS03225 ENOG4105EWK phytoene EI545_RS03240 ENOG4108JQ9 ABC transporter EI545_RS03245 ENOG41083U2 ABC transporter, permease EI545_RS03255 ENOG4105DZC cytosine deaminase EI545_RS03260 ENOG4106PBJ Serine threonine-protein kinase Pkn6 EI545_RS03285 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) EI545_RS03295 ENOG4105DH8 myo-inositol catabolism EI545_RS03315 ENOG4108JEH abc transporter atp-binding protein EI545_RS03320 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) EI545_RS03345 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EI545_RS03355 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EI545_RS03375 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS03395 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) EI545_RS03410 ENOG4105C1J atp-dependent rna helicase EI545_RS03425 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase EI545_RS03430 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EI545_RS03435 ENOG4105C8S subunit m EI545_RS03440 ENOG4105D65 subunit l EI545_RS03445 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EI545_RS03455 ENOG4105DF2 NADH dehydrogenase subunit j EI545_RS03460 ENOG4108048 decarboxylase EI545_RS03470 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) EI545_RS03480 ENOG4107R0R NADH dehydrogenase subunit g EI545_RS03495 ENOG410627S EI545_RS03510 ENOG4107QIZ NADH dehydrogenase EI545_RS03515 ENOG41063P3 EI545_RS03520 ENOG4105CE9 30S ribosomal protein S2 EI545_RS03525 ENOG4105GKE subunit e EI545_RS03535 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EI545_RS03540 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EI545_RS03545 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EI545_RS03550 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EI545_RS03560 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EI545_RS03565 ENOG4105KK6 nuclease EI545_RS03585 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EI545_RS03610 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EI545_RS03625 ENOG4105C8Y Acetylornithine aminotransferase EI545_RS03630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EI545_RS03635 ENOG4108UTW Plays a role in the regulation of phosphate uptake EI545_RS03640 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EI545_RS03645 ENOG4108RVA ribokinase EI545_RS03650 ENOG4105NWF RbsD or FucU transport EI545_RS03670 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EI545_RS03675 ENOG4105NWF RbsD or FucU transport EI545_RS03690 ENOG4105CN9 Peptidase m42 family protein EI545_RS03695 ENOG4106P19 photosystem i assembly btpa EI545_RS03705 ENOG4108RVA ribokinase EI545_RS03715 ENOG4107XBN GntR Family Transcriptional Regulator EI545_RS03720 ENOG4105CTX dehydratase EI545_RS03730 ENOG4105D38 putrescine abc transporter EI545_RS03740 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS03750 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) EI545_RS03755 ENOG4105E0C molybdate abc transporter EI545_RS03760 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EI545_RS03765 ENOG4105F4R Transcriptional regulator mode EI545_RS03780 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) EI545_RS03790 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EI545_RS03815 ENOG4105D98 threonine synthase EI545_RS03825 ENOG4107QS1 Cytochrome C Oxidase, Subunit III EI545_RS03830 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) EI545_RS03840 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EI545_RS03845 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) EI545_RS03850 ENOG4105D1U peptidase U62 modulator of DNA gyrase EI545_RS03910 ENOG4105CHJ isochorismatase hydrolase EI545_RS03930 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EI545_RS03950 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase EI545_RS03955 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EI545_RS03990 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS04000 ENOG4105D38 putrescine abc transporter EI545_RS04005 ENOG4108HM4 ABC transporter EI545_RS04010 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EI545_RS04020 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EI545_RS04025 ENOG4105CHR reductase EI545_RS04030 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase EI545_RS04040 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase EI545_RS04055 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EI545_RS04100 ENOG4105CNN ABC, transporter EI545_RS04110 ENOG4105C2J ABC transporter EI545_RS04215 ENOG4108VX5 3-methyladenine DNA glycosylase EI545_RS04225 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EI545_RS04235 ENOG4108Z9Z response to DNA damage stimulus EI545_RS04250 ENOG4105DQE DNA ligase EI545_RS04255 ENOG4105FDF Could be involved in DNA repair (By similarity) EI545_RS04265 ENOG4105DZG Dehydrogenase EI545_RS04285 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) EI545_RS04290 ENOG4105BZ9 Cytochrome C oxidase, subunit I EI545_RS04310 ENOG4108RT4 succinoglycan biosynthesis EI545_RS04385 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EI545_RS04400 ENOG4105CPQ Dehydrogenase EI545_RS04405 ENOG4105C5I Dehydrogenase EI545_RS04410 ENOG4105CHR reductase EI545_RS04415 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EI545_RS04420 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EI545_RS04430 ENOG4105DIQ Transcriptional regulator EI545_RS04435 ENOG4105DIQ Transcriptional regulator EI545_RS04445 ENOG4105CNN ABC, transporter EI545_RS04520 ENOG4107TRE AP endonuclease, family 2 EI545_RS04525 ENOG4107TRE AP endonuclease, family 2 EI545_RS04530 ENOG4105CXK mandelate racemase muconate lactonizing EI545_RS04540 ENOG4108JQ1 Dehydrogenase EI545_RS04550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS04595 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EI545_RS04610 ENOG4105XJC Two component transcriptional regulator (Winged helix family EI545_RS04635 ENOG4105CJ2 (LipO)protein EI545_RS04655 ENOG4108T5G Adenylate EI545_RS04700 ENOG4105CPQ Dehydrogenase EI545_RS04735 ENOG4105CEI nitrite reductase EI545_RS04745 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EI545_RS04755 ENOG4105DSP amino acid AbC transporter EI545_RS04760 ENOG4105E5Q amino acid AbC transporter EI545_RS04765 ENOG4105CDA abc transporter atp-binding protein EI545_RS04780 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 EI545_RS04785 ENOG4105DKT Transcriptional regulator EI545_RS04805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS04810 ENOG4105CHR reductase EI545_RS04815 ENOG4105DEI Mannitol dehydrogenase EI545_RS04830 ENOG4105C32 Amino acid ABC transporter (Permease) EI545_RS04835 ENOG4105CNN ABC, transporter EI545_RS04840 ENOG4105C0Z ABC transporter EI545_RS04845 ENOG4108IV0 ABC, transporter EI545_RS04875 ENOG4105E2V Glycosyltransferase 36 EI545_RS04880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EI545_RS04900 ENOG4105CNV Aldolase EI545_RS04920 ENOG4105CHR reductase EI545_RS04945 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component EI545_RS04965 ENOG4105C2C drug resistance transporter, Bcr CflA EI545_RS04970 ENOG4105CQZ Histidine kinase EI545_RS04975 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EI545_RS04995 ENOG4105DEN Luciferase family EI545_RS05055 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EI545_RS05065 ENOG4107YCY Transcriptional regulator EI545_RS05070 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS05075 ENOG4105F38 ABC transporter, permease EI545_RS05080 ENOG4105D38 putrescine abc transporter EI545_RS05090 ENOG4105DZC cytosine deaminase EI545_RS05095 ENOG4107XWI flavin reductase domain protein, FMN-binding EI545_RS05100 ENOG410633P Hydantoin racemase EI545_RS05125 ENOG4107T9Q phosphonate abc transporter EI545_RS05130 ENOG4105D5T phosphonate abc transporter EI545_RS05150 ENOG4107SK7 Sarcosine-dimethylglycine methyltransferase EI545_RS05155 ENOG4105CPN adenine deaminase EI545_RS05160 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EI545_RS05165 ENOG4105FD8 phosphonate metabolism protein PhnM EI545_RS05180 ENOG4105HRV phosphonate c-p lyase system protein phnl EI545_RS05185 ENOG4105ENV phosphonate C-P lyase system protein PhnK EI545_RS05225 ENOG4108IND Tetr family transcriptional regulator EI545_RS05230 ENOG4108IJ6 ABC transporter EI545_RS05235 ENOG4105ECW sulfate abc transporter EI545_RS05245 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EI545_RS05255 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family EI545_RS05260 ENOG4108XM1 transcriptional regulator AsnC family EI545_RS05305 ENOG4107R3N Filamentation induced by cAMP protein fic EI545_RS05335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EI545_RS05380 ENOG4105C9U ATP-dependent DNA helicase RecQ EI545_RS05400 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) EI545_RS05425 ENOG41065RQ ADP-ribosylation crystallin J1 EI545_RS05435 ENOG4105D1H recombination factor protein RarA EI545_RS05475 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 EI545_RS05510 ENOG4105EFZ amidohydrolase EI545_RS05515 ENOG4105CYW agmatinase EI545_RS05535 ENOG4105CTD carboxy-peptidase EI545_RS05540 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) EI545_RS05580 ENOG4105E18 UPF0276 protein EI545_RS05590 ENOG4105C22 threonyL-tRNA synthetase EI545_RS05600 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EI545_RS05610 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class EI545_RS05630 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EI545_RS05635 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EI545_RS05640 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EI545_RS05650 ENOG4105DDR sarcosine oxidase (Beta subunit) EI545_RS05680 ENOG4105D6E homoserine dehydrogenase EI545_RS05685 ENOG4105CBT Fructose-1,6-bisphosphatase EI545_RS05695 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EI545_RS05715 ENOG4105VNH ABC transporter solute-binding protein EI545_RS05725 ENOG4105D38 putrescine abc transporter EI545_RS05730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS05735 ENOG4105BZU Histidine kinase EI545_RS05745 ENOG4108MAJ Membrane EI545_RS05760 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EI545_RS05785 ENOG4105KSC Transcriptional regulator, TraR DksA family EI545_RS05795 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EI545_RS05815 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr EI545_RS05825 ENOG4105CMR udp-glucose 4-epimerase EI545_RS05835 ENOG4105C6Y Udp-glucose 6-dehydrogenase EI545_RS05855 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) EI545_RS05865 ENOG4105CDY transcriptional regulatory protein EI545_RS05885 ENOG4107QRT dEAD DEAH box helicase EI545_RS05895 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EI545_RS05900 ENOG4105CQC Prephenate dehydratase EI545_RS05905 ENOG4105CKU formyltetrahydrofolate synthetase EI545_RS05915 ENOG4107QUT magnesium and cobalt transport protein CorA EI545_RS05925 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EI545_RS05935 ENOG4105KCK Peptidoglycan-associated lipoprotein EI545_RS05955 ENOG4108ZZF transport protein (ExbD) EI545_RS05960 ENOG4105E02 MotA TolQ exbB proton channel EI545_RS05965 ENOG4107YD3 Thioesterase EI545_RS05975 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EI545_RS06015 ENOG4105C25 Primosomal protein n' EI545_RS06030 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EI545_RS06035 ENOG4105VE1 Phosphatidylcholine synthase EI545_RS06050 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EI545_RS06055 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EI545_RS06060 ENOG4105C3M thioredoxin reductase EI545_RS06085 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EI545_RS06095 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EI545_RS06110 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EI545_RS06125 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EI545_RS06130 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EI545_RS06145 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EI545_RS06150 ENOG4107RCQ (CBS) domain EI545_RS06155 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EI545_RS06160 ENOG4105C9A Phoh family EI545_RS06170 ENOG4105UYK outer membrane protein a EI545_RS06190 ENOG41090R7 Ferric uptake EI545_RS06200 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) EI545_RS06215 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EI545_RS06225 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) EI545_RS06245 ENOG4105Y3U Transglycosylase-associated protein EI545_RS06265 ENOG4105DY8 decarboxylase EI545_RS06295 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EI545_RS06335 ENOG4105C02 permease EI545_RS06345 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) EI545_RS06350 ENOG4107R33 ppx gppa phosphatase EI545_RS06360 ENOG4108Z7F N-acetyltransferase EI545_RS06365 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EI545_RS06415 ENOG4107QX3 carboxylase EI545_RS06430 ENOG4105CFF transcriptional regulator EI545_RS06445 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EI545_RS06460 ENOG4108IJ7 Glycine betaine EI545_RS06475 ENOG4108JPW Aminotransferase EI545_RS06485 ENOG4108JJB ABC transporter EI545_RS06490 ENOG4107YZB Cobalt transport protein EI545_RS06495 ENOG4107ZYJ bioY protein EI545_RS06510 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EI545_RS06515 ENOG4105SYT Methylenetetrahydrofolate reductase EI545_RS06520 ENOG4105DZ2 Transcriptional regulator EI545_RS06525 ENOG4105CKD glutathione-regulated potassium-efflux system protein EI545_RS06540 ENOG4105ECY inositol monophosphatase EI545_RS06550 ENOG4105C26 Dehydrogenase EI545_RS06555 ENOG4105EW9 transcriptional regulator AsnC family EI545_RS06585 ENOG4108HWW ABC transporter EI545_RS06595 ENOG4105DFW ABC transporter EI545_RS06605 ENOG4107EJG GntR family transcriptional regulator EI545_RS06610 ENOG41062B0 ABC transporter, permease EI545_RS06615 ENOG4107R9N ABC transporter EI545_RS06620 ENOG4105C2J ABC transporter EI545_RS06625 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator EI545_RS06630 ENOG41065G1 UPF0391 membrane protein EI545_RS06635 ENOG4105VDW Csbd family EI545_RS06660 ENOG41074H6 response regulator EI545_RS06695 ENOG4105DSF transport protein EI545_RS06700 ENOG4108HQS Glycine betaine EI545_RS06705 ENOG4108IJ7 Glycine betaine EI545_RS06755 ENOG4105CHR reductase EI545_RS06760 ENOG4107XBN GntR Family Transcriptional Regulator EI545_RS06785 ENOG4105DRR Transcriptional regulator, GntR family EI545_RS06790 ENOG4107EFR Flavocytochrome c EI545_RS06795 ENOG41079YP Citrate utilization protein b EI545_RS06805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS06810 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component EI545_RS06820 ENOG4105BZ7 extracellular solute-binding protein family 1 EI545_RS06840 ENOG4108ZJD Protein of unknown function (DUF1109) EI545_RS06845 ENOG4105NCT RNA Polymerase EI545_RS06850 ENOG4105CGH 5'-nucleotidase EI545_RS06885 ENOG4105E55 glycerol-3-phosphate acyltransferase EI545_RS06905 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EI545_RS06910 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EI545_RS06925 ENOG4105E33 succinate dehydrogenase EI545_RS06945 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) EI545_RS06950 ENOG4105PDA succinate dehydrogenase, hydrophobic membrane anchor protein EI545_RS06955 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) EI545_RS06960 ENOG4105DJG MaoC domain protein dehydratase EI545_RS06990 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EI545_RS07015 ENOG4105CMV Succinyl-CoA synthetase subunit beta EI545_RS07030 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EI545_RS07055 ENOG4107QN2 dihydrolipoyl dehydrogenase EI545_RS07060 ENOG4105EUB pirin domain protein EI545_RS07065 ENOG4108WYP Transcriptional regulator EI545_RS07095 ENOG4105C1J atp-dependent rna helicase EI545_RS07100 ENOG4107104 thymidine kinase EI545_RS07120 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EI545_RS07125 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EI545_RS07130 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EI545_RS07135 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EI545_RS07140 ENOG4105KG3 cytidine deaminase EI545_RS07150 ENOG4105C6K Malic enzyme EI545_RS07155 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EI545_RS07165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EI545_RS07175 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EI545_RS07195 ENOG4105EV9 Alpha Beta Hydrolase EI545_RS07205 ENOG4105C0A alcohol dehydrogenase EI545_RS07210 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EI545_RS07235 ENOG4108IJ9 (ABC) transporter EI545_RS07245 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EI545_RS07250 ENOG4105E98 transcriptional regulator DeoR family EI545_RS07265 ENOG4105K63 Thioredoxin EI545_RS07285 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EI545_RS07290 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EI545_RS07300 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EI545_RS07310 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EI545_RS07315 ENOG4105DE4 1-phosphofructokinase EI545_RS07325 ENOG4105C4K Nad synthetase EI545_RS07340 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein EI545_RS07350 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EI545_RS07375 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EI545_RS07385 ENOG4105CJN penicillin-binding protein EI545_RS07390 ENOG4105CNI cell division protein FtsW EI545_RS07400 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase EI545_RS07410 ENOG4105C5F glutamine synthetase EI545_RS07415 ENOG4105C26 Dehydrogenase EI545_RS07420 ENOG4105C0A alcohol dehydrogenase EI545_RS07425 ENOG4105MWK D-amino acid dehydrogenase, small subunit EI545_RS07465 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EI545_RS07470 ENOG4105CHM Aminotransferase EI545_RS07475 ENOG4105C7K acetolactate synthase EI545_RS07485 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EI545_RS07495 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EI545_RS07505 ENOG4106K28 UPF0283 membrane protein EI545_RS07510 ENOG4105CM6 amino acid regulated cytosolic protein EI545_RS07515 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EI545_RS07520 ENOG4108IRC dna polymerase iii EI545_RS07525 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EI545_RS07540 ENOG4107QN1 sodium solute EI545_RS07550 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EI545_RS07555 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EI545_RS07560 ENOG4105CHH sulfate transporter EI545_RS07580 ENOG4105DK7 lysyl-tRNA synthetase EI545_RS07605 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EI545_RS07615 ENOG4105C5H ABC transporter EI545_RS07635 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EI545_RS07645 ENOG4105DEF Extracellular solute-binding protein, family 5 EI545_RS07655 ENOG4108JQ6 ABC transporter EI545_RS07695 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EI545_RS07730 ENOG4105D8X mechanosensitive ion channel EI545_RS07765 ENOG4105ES5 Histidine kinase EI545_RS07785 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EI545_RS07790 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EI545_RS07795 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EI545_RS07810 ENOG4105BZU Histidine kinase EI545_RS07855 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EI545_RS07860 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EI545_RS07875 ENOG4108I0Y (ABC) transporter EI545_RS07880 ENOG4108UJV acyl-CoA thioesterase i EI545_RS07885 ENOG4105CDA abc transporter atp-binding protein EI545_RS07890 ENOG4105DRP amino acid AbC transporter EI545_RS07895 ENOG4105EZ7 amino acid ABC transporter EI545_RS07900 ENOG4107QXX ABC transporter EI545_RS07910 ENOG4105EI2 Pseudouridine synthase EI545_RS07915 ENOG41082CG Protein CrcB homolog EI545_RS07920 ENOG4105D1H recombination factor protein RarA EI545_RS07935 ENOG4108ZT0 50S ribosomal protein l17 EI545_RS07945 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EI545_RS07950 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EI545_RS07955 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EI545_RS07960 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EI545_RS07970 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) EI545_RS07980 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EI545_RS07985 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EI545_RS07990 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EI545_RS08000 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EI545_RS08005 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EI545_RS08010 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EI545_RS08025 ENOG41083MP 50s ribosomal protein l29 EI545_RS08055 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EI545_RS08060 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EI545_RS08070 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EI545_RS08080 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EI545_RS08085 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EI545_RS08090 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EI545_RS08135 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EI545_RS08145 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EI545_RS08150 ENOG4108VZM 50s ribosomal protein L10 EI545_RS08160 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EI545_RS08165 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EI545_RS08180 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EI545_RS08190 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EI545_RS08200 ENOG4105E1F short-chain dehydrogenase reductase EI545_RS08210 ENOG4108WBT adenosyltransferase EI545_RS08215 ENOG4105TPV EI545_RS08230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EI545_RS08250 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EI545_RS08260 ENOG4105EB3 Histidine kinase EI545_RS08265 ENOG4105E3W Two component transcriptional regulator (Winged helix family EI545_RS08270 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase EI545_RS08280 ENOG4105C1G acyl-Coa dehydrogenase EI545_RS08295 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) EI545_RS08305 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EI545_RS08315 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EI545_RS08320 ENOG4105C3F Signal peptidase i EI545_RS08325 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) EI545_RS08365 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EI545_RS08385 ENOG4105EN6 Membrane EI545_RS08400 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EI545_RS08410 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EI545_RS08415 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EI545_RS08420 ENOG4105C87 Aminotransferase class I and II EI545_RS08435 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) EI545_RS08475 ENOG4105E3J oxidoreductase EI545_RS08485 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EI545_RS08520 ENOG4105CBC glutamate synthase EI545_RS08525 ENOG4105M90 Glutamate synthase alpha subunit domain protein EI545_RS08530 ENOG4105EYU Glutamine amido-transferase EI545_RS08545 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EI545_RS08550 ENOG4105WIU sarcosine oxidase delta subunit EI545_RS08555 ENOG4105DDR sarcosine oxidase (Beta subunit) EI545_RS08565 ENOG4105E6M Sulphatase-modifying factor protein EI545_RS08570 ENOG4108YYH Nadph-dependent fmn reductase EI545_RS08580 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) EI545_RS08590 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) EI545_RS08600 ENOG41090TK Short-chain dehydrogenase reductase Sdr EI545_RS08605 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EI545_RS08610 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EI545_RS08645 ENOG4105C58 cytochrome c oxidase accessory protein ccog EI545_RS08650 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) EI545_RS08665 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i EI545_RS08680 ENOG4105DS0 Transcriptional regulator, Crp Fnr family EI545_RS08685 ENOG4105D4P Coproporphyrinogen iii oxidase EI545_RS08690 ENOG4105JNK Glycosyl transferase (Group 1 EI545_RS08695 ENOG4108JQ5 ABC transporter EI545_RS08700 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component EI545_RS08705 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component EI545_RS08710 ENOG4105E43 Extracellular solute-binding protein, family 5 EI545_RS08715 ENOG4105G9V cytochrome C EI545_RS08730 ENOG4105E09 nadh pyrophosphatase EI545_RS08735 ENOG4105CGH 5'-nucleotidase EI545_RS08740 ENOG4107VXZ Hydrolase EI545_RS08760 ENOG4105J7D transcriptional regulator EI545_RS08770 ENOG4107QMP dna polymerase iii subunits gamma and tau EI545_RS08780 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EI545_RS08785 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EI545_RS08790 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) EI545_RS08795 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EI545_RS08805 ENOG4105YA8 Transcriptional regulator EI545_RS08840 ENOG4105RK9 auxin efflux carrier EI545_RS08845 ENOG4105C4W S-formylglutathione hydrolase EI545_RS08855 ENOG4108UPT UPF0178 protein EI545_RS08860 ENOG4108SXK Transporter Drug Metabolite Exporter family EI545_RS08870 ENOG4105CIF Ornithine Cyclodeaminase EI545_RS08875 ENOG4105VTR Integrase EI545_RS08885 ENOG41090BB DNA mismatch endonuclease (vsr) EI545_RS08930 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EI545_RS08935 ENOG4105BZU Histidine kinase EI545_RS08945 ENOG4108EHX EamA-like transporter family EI545_RS08950 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EI545_RS08965 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EI545_RS08980 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EI545_RS08995 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EI545_RS09000 ENOG4105DFI Membrane EI545_RS09010 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EI545_RS09015 ENOG4107SC1 transglycosylase EI545_RS09035 ENOG4105KHC sulfurtransferase EI545_RS09040 ENOG4105CGF Aromatic amino acid aminotransferase EI545_RS09050 ENOG4105BZU Histidine kinase EI545_RS09055 ENOG4108YZA Nitrogen regulatory protein pii EI545_RS09060 ENOG4108JQC penicillin-binding protein 1A EI545_RS09065 ENOG410903D sensor protein EI545_RS09095 ENOG4105KZX Pterin carbinolamine dehydratase EI545_RS09110 ENOG4106H78 methyltransferase EI545_RS09120 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EI545_RS09130 ENOG4105CC0 LysR family Transcriptional regulator EI545_RS09135 ENOG4105CDV Ompa motb domain protein EI545_RS09145 ENOG4108I62 cina-like protein EI545_RS09150 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EI545_RS09165 ENOG4105C01 Dihydroxy-acid dehydratase EI545_RS09175 ENOG4105CAK Cell division ATP-binding protein ftsE EI545_RS09220 ENOG4107S8C mandelate racemase muconate lactonizing EI545_RS09260 ENOG4105CA9 Pyruvate kinase EI545_RS09275 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EI545_RS09280 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EI545_RS09285 ENOG4108T58 Mg2 transport protein CorA EI545_RS09290 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EI545_RS09295 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EI545_RS09310 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EI545_RS09315 ENOG4107FW0 short-chain dehydrogenase reductase EI545_RS09335 ENOG4105CVN desaturase EI545_RS09340 ENOG4105K6V RNA polymerase EI545_RS09345 ENOG4108NIX Factor ChrR EI545_RS09360 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EI545_RS09395 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EI545_RS09425 ENOG4105C1B dTDP-glucose 4-6-dehydratase EI545_RS09445 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EI545_RS09450 ENOG4108IEG Formate dehydrogenase Alpha subunit EI545_RS09455 ENOG4107QIZ NADH dehydrogenase EI545_RS09480 ENOG4105CHR reductase EI545_RS09485 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EI545_RS09495 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EI545_RS09505 ENOG4108ZAF Molybdopterin EI545_RS09515 ENOG41082W1 Cupin 2, conserved barrel domain protein EI545_RS09545 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EI545_RS09550 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EI545_RS09600 ENOG4105RX8 Protein of unknown function (DUF1523) EI545_RS09610 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EI545_RS09625 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EI545_RS09640 ENOG4107ZT5 Thiol disulfide interchange protein EI545_RS09660 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 EI545_RS09665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EI545_RS09670 ENOG4107QJN gtp cyclohydrolase ii EI545_RS09705 ENOG4105DFA alanine racemase domain protein EI545_RS09715 ENOG4105TXM Domain of unknown function (DUF3576) EI545_RS09720 ENOG4105C8T Leucyl-tRNA synthetase EI545_RS09745 ENOG4107RSM transcriptional regulator EI545_RS09755 ENOG4107TYH extracellular solute-binding protein family 1 EI545_RS09760 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS09765 ENOG4105D81 ABC transporter, permease EI545_RS09770 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component EI545_RS09775 ENOG4105C26 Dehydrogenase EI545_RS09805 ENOG4105C1B dTDP-glucose 4-6-dehydratase EI545_RS09810 ENOG4108YXU transcriptional regulator AsnC family EI545_RS09815 ENOG4105DCF alanine dehydrogenase EI545_RS09820 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) EI545_RS09825 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) EI545_RS09830 ENOG4105CYM Glutathione S-transferase EI545_RS09835 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EI545_RS09840 ENOG4105CSU acyl-Coa dehydrogenase EI545_RS09865 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EI545_RS09870 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b EI545_RS09895 ENOG4105D3G Pseudouridine synthase EI545_RS09910 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EI545_RS09940 ENOG4105MWK D-amino acid dehydrogenase, small subunit EI545_RS09945 ENOG4105D9P serine threonine protein kinase EI545_RS09955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EI545_RS09970 ENOG4105DSE periplasmic solute binding protein EI545_RS09975 ENOG4105CC5 ABC transporter EI545_RS09980 ENOG4105DIK (ABC) transporter EI545_RS09990 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit EI545_RS10010 ENOG4105CNN ABC, transporter EI545_RS10015 ENOG4105C2J ABC transporter EI545_RS10030 ENOG4105DKT Transcriptional regulator EI545_RS10040 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EI545_RS10045 ENOG4105CNV Aldolase EI545_RS10060 ENOG4106SMU thiamine transporter membrane protein EI545_RS10065 ENOG4107T0D ABC, transporter EI545_RS10070 ENOG4105EIX cytochrome c1 EI545_RS10075 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EI545_RS10080 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EI545_RS10115 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EI545_RS10145 ENOG4105FYV Amp nucleosidase EI545_RS10165 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EI545_RS10170 ENOG4105DFW ABC transporter EI545_RS10175 ENOG4108HWW ABC transporter EI545_RS10185 ENOG4105CMG Carbohydrate kinase EI545_RS10195 ENOG4107U9T Pfam:Ribonuclease_BN EI545_RS10200 ENOG4105CPC Aldo Keto reductase EI545_RS10220 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EI545_RS10225 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EI545_RS10235 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EI545_RS10240 ENOG4105CTB Polyprenyl synthetase EI545_RS10245 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EI545_RS10265 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EI545_RS10270 ENOG41090HR transcriptional regulator EI545_RS10275 ENOG4105CM2 brancheD-chain amino acid aminotransferase EI545_RS10280 ENOG4108ZHJ Organic hydroperoxide resistance protein EI545_RS10285 ENOG4105K56 Transcriptional regulator EI545_RS10290 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EI545_RS10310 ENOG4105K63 Thioredoxin EI545_RS10315 ENOG4108R3E Dna-3-methyladenine glycosylase i EI545_RS10345 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EI545_RS10355 ENOG4105EAH synthase EI545_RS10375 ENOG410890F Dynamin family EI545_RS10395 ENOG4105CE4 GlcNAc 6-P deacetylase EI545_RS10400 ENOG4105ER2 Ompa motb domain protein EI545_RS10405 ENOG4105BZE flagellar hook protein, FlgE EI545_RS10420 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EI545_RS10425 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EI545_RS10430 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) EI545_RS10435 ENOG4105C2X Arabinose 5-phosphate isomerase EI545_RS10445 ENOG4105RF0 OstA family EI545_RS10450 ENOG4108IUZ ABC transporter EI545_RS10455 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea EI545_RS10460 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN EI545_RS10490 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) EI545_RS10495 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase EI545_RS10525 ENOG4105W5Q DNA repair protein (RadC EI545_RS10540 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EI545_RS10545 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EI545_RS10550 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EI545_RS10555 ENOG4105M6F mutator MutT protein EI545_RS10560 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EI545_RS10575 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EI545_RS10580 ENOG4105CFU surface antigen EI545_RS10595 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EI545_RS10600 ENOG4105E3R (LipO)protein EI545_RS10615 ENOG4105VW4 glutaredoxin 3 EI545_RS10620 ENOG41081UC Inherit from COG: Competence protein EI545_RS10630 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EI545_RS10660 ENOG4105BZ1 (ABC) transporter EI545_RS10665 ENOG4105BZ1 (ABC) transporter EI545_RS10675 ENOG4105P8F nudix hydrolase EI545_RS10685 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EI545_RS10700 ENOG4105C7B Threonine dehydratase EI545_RS10715 ENOG4106JDR secreted EI545_RS10730 ENOG4105CM2 brancheD-chain amino acid aminotransferase EI545_RS10735 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EI545_RS10740 ENOG4105ERH Fumarylacetoacetate hydrolase EI545_RS10770 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 EI545_RS10785 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EI545_RS10795 ENOG4108UHJ MAF-like protein EI545_RS10800 ENOG4108YXA Membrane EI545_RS10805 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EI545_RS10810 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EI545_RS10815 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EI545_RS10820 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) EI545_RS10835 ENOG4105CSA Coproporphyrinogen iii oxidase EI545_RS10840 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EI545_RS10850 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EI545_RS10855 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EI545_RS10860 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EI545_RS10880 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) EI545_RS10885 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EI545_RS10900 ENOG4108IG5 Transcriptional regulator EI545_RS10930 ENOG4105CYW agmatinase EI545_RS10945 ENOG4105CMS peptidase U62, modulator of DNA gyrase EI545_RS10950 ENOG4105ECY inositol monophosphatase EI545_RS10970 ENOG4105EDK PfkB domain protein EI545_RS10975 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) EI545_RS10990 ENOG4105CIB oxidoreductase Domain protein EI545_RS10995 ENOG4105ETE Transcriptional regulator (LacI family EI545_RS11000 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EI545_RS11010 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EI545_RS11015 ENOG4107QM2 Aldo Keto reductase EI545_RS11030 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EI545_RS11035 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit EI545_RS11050 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EI545_RS11055 ENOG4108R85 Short chain dehydrogenase EI545_RS11065 ENOG4105CHR reductase EI545_RS11075 ENOG4107QP6 Xylose isomerase domain protein TIM barrel EI545_RS11080 ENOG4105ETE Transcriptional regulator (LacI family EI545_RS11085 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EI545_RS11090 ENOG4105C2J ABC transporter EI545_RS11100 ENOG4105CNN ABC, transporter EI545_RS11110 ENOG4107TYG Oxidoreductase domain-containing protein EI545_RS11115 ENOG4105ETE Transcriptional regulator (LacI family EI545_RS11125 ENOG4105F38 ABC transporter, permease EI545_RS11130 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component EI545_RS11135 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS11140 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EI545_RS11175 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EI545_RS11200 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase EI545_RS11205 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EI545_RS11210 ENOG4105CEY Amp-dependent synthetase and ligase EI545_RS11215 ENOG4105DG4 malate L-lactate dehydrogenase EI545_RS11220 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EI545_RS11235 ENOG4105ERH Fumarylacetoacetate hydrolase EI545_RS11240 ENOG4105FDP GntR family transcriptional regulator EI545_RS11245 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase EI545_RS11255 ENOG4105E9K Isocitrate dehydrogenase EI545_RS11275 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase EI545_RS11280 ENOG4105DND Transcriptional regulator EI545_RS11285 ENOG4107SS6 2-dehydro-3-deoxygluconokinase EI545_RS11300 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EI545_RS11310 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EI545_RS11315 ENOG4105M5J Cupin 2, conserved barrel domain protein EI545_RS11325 ENOG4105CHR reductase EI545_RS11330 ENOG4105DEI Mannitol dehydrogenase EI545_RS11335 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) EI545_RS11360 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EI545_RS11370 ENOG4105DTD Dehydrogenase EI545_RS11375 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EI545_RS11380 ENOG4105E39 Enoyl-CoA hydratase EI545_RS11385 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EI545_RS11390 ENOG4105CHU acetyl-coa acetyltransferase EI545_RS11400 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) EI545_RS11425 ENOG4106IPI cyclase, family EI545_RS11430 ENOG4107VFM Dehydrogenase EI545_RS11440 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EI545_RS11445 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EI545_RS11465 ENOG4105C4Y ABC transporter EI545_RS11470 ENOG4107RCV ABC transporter, permease EI545_RS11480 ENOG4105ECY inositol monophosphatase EI545_RS11485 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 EI545_RS11515 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EI545_RS11545 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) EI545_RS11550 ENOG4108R7K Metal Dependent Phosphohydrolase EI545_RS11555 ENOG410810E transcriptional regulator, lysR family EI545_RS11560 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS EI545_RS11565 ENOG4108UYB regulatoR EI545_RS11570 ENOG4108ZX6 Electron transport protein SCO1 SenC EI545_RS11575 ENOG4105TX3 Histidine kinase EI545_RS11590 ENOG4105EHM Aminoglycoside phosphotransferase EI545_RS11595 ENOG4108S0S Nucleotidyl transferase EI545_RS11600 ENOG4107RMM double-strand break repair protein Addb EI545_RS11605 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EI545_RS11610 ENOG4105K63 Thioredoxin EI545_RS11615 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EI545_RS11620 ENOG4105CKI cobalamin synthesis protein EI545_RS11635 ENOG4105D3R alkyl hydroperoxide reductase EI545_RS11645 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EI545_RS11650 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EI545_RS11660 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EI545_RS11665 ENOG4105CN7 Flagellar biosynthetic protein FliP EI545_RS11670 ENOG4105DD5 Flagellar motor switch protein EI545_RS11680 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EI545_RS11700 ENOG4107RD7 Flagellar Motor Protein, MotA EI545_RS11720 ENOG4105D7B Flagellar biosynthesis protein flha EI545_RS11730 ENOG4105D00 flagellar biosynthetic protein flhB EI545_RS11745 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EI545_RS11755 ENOG4105CGA flagellar basal-body rod protein FlgG EI545_RS11760 ENOG4105KTQ flagellar basal-body rod protein EI545_RS11765 ENOG4105VS8 Flagellar biosynthetic protein fliq EI545_RS11770 ENOG4105X50 flagellar hook-basal body complex protein fliE EI545_RS11775 ENOG4108ZC9 flagellar basal-body rod protein flgc EI545_RS11795 ENOG4105IE4 repressor protein FlbT EI545_RS11825 ENOG410822I Flagellar hook capping protein EI545_RS11845 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EI545_RS11850 ENOG4105E39 Enoyl-CoA hydratase EI545_RS11870 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EI545_RS11895 ENOG4105DIQ Transcriptional regulator EI545_RS11900 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EI545_RS11905 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EI545_RS11960 ENOG4105EEF Alkane 1-monooxygenase EI545_RS11965 ENOG4105CEN a g-specific adenine glycosylase EI545_RS11985 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) EI545_RS12030 ENOG4108UQY Iron-storage protein EI545_RS12045 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EI545_RS12050 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) EI545_RS12070 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EI545_RS12075 ENOG4108KEZ Dehydrogenase EI545_RS12090 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) EI545_RS12095 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) EI545_RS12160 ENOG4105EJC lysr family transcriptional regulator EI545_RS12215 ENOG410645S MarR family Transcriptional regulator EI545_RS12225 ENOG4105KIP Thioesterase EI545_RS12230 ENOG4106WTF Glycosyl transferase, family 2 EI545_RS12245 ENOG4105CHR reductase EI545_RS12250 ENOG4105C5B carbamate kinase EI545_RS12270 ENOG4105CSX c4-dicarboxylate anaerobic carrier EI545_RS12275 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EI545_RS12285 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein EI545_RS12315 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EI545_RS12320 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EI545_RS12325 ENOG4105C1P efflux transporter, rnd family, mfp subunit EI545_RS12330 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EI545_RS12340 ENOG4105CH2 amidohydrolase EI545_RS12345 ENOG41086D8 Transcriptional regulator EI545_RS12360 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EI545_RS12395 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase EI545_RS12410 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EI545_RS12420 ENOG410903D sensor protein EI545_RS12425 ENOG41074H6 response regulator EI545_RS12485 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) EI545_RS12495 ENOG4108JQ9 ABC transporter EI545_RS12500 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) EI545_RS12540 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EI545_RS12615 ENOG4105CS6 Rhs element vgr protein EI545_RS12735 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) EI545_RS12745 ENOG4105EHG Permease protein EI545_RS12750 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EI545_RS12800 ENOG4105QUC reductase EI545_RS12815 ENOG4105CIA precorrin-4 C(11)-methyltransferase EI545_RS12820 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EI545_RS12840 ENOG4105CRN Aminoglycoside phosphotransferase EI545_RS12845 ENOG4105DYS nad(p)h dehydrogenase (quinone) EI545_RS12870 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY EI545_RS12890 ENOG4108428 Inherit from COG: -acetyltransferase EI545_RS12900 ENOG4105K5M 30s ribosomal protein S16 EI545_RS12905 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase EI545_RS12910 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EI545_RS12930 ENOG41082FS 50S ribosomal protein L31 EI545_RS12940 ENOG4107QJE Chromosome Partitioning Protein EI545_RS12955 ENOG41081E4 ATP synthase F0 subunit I EI545_RS12960 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) EI545_RS12965 ENOG4105VD1 ATP synthase subunit C EI545_RS12975 ENOG4105N5Q Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) EI545_RS12980 ENOG41073TP transcriptional regulator EI545_RS12985 ENOG4108ZG0 Ompa motb domain protein EI545_RS12990 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EI545_RS13010 ENOG4105CYW agmatinase EI545_RS13020 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS13030 ENOG4105EG2 ABC transporter, permease EI545_RS13050 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EI545_RS13065 ENOG4105FC8 fad dependent oxidoreductase EI545_RS13085 ENOG4105UIB (ABC) transporter EI545_RS13090 ENOG4108JQ9 ABC transporter EI545_RS13100 ENOG4105C7W Xanthine dehydrogenase EI545_RS13130 ENOG4105CUT histidyl-tRNA synthetase EI545_RS13135 ENOG4105P5X ATP phosphoribosyltransferase regulatory subunit EI545_RS13140 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EI545_RS13170 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EI545_RS13175 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family EI545_RS13200 ENOG4105NPE arsR family transcriptional regulator EI545_RS13205 ENOG4108TEB UPF0114 protein EI545_RS13210 ENOG4105FE5 Homospermidine synthase EI545_RS13215 ENOG4105CIH Imidazole acetol-phosphate transaminase EI545_RS13235 ENOG4108NH8 Cation transport protein EI545_RS13255 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EI545_RS13315 ENOG4108ZZ3 UPF0260 protein EI545_RS13320 ENOG4105DTN riboflavin biosynthesis protein ribF EI545_RS13325 ENOG4108Z7G MaoC domain protein dehydratase EI545_RS13335 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase EI545_RS13340 ENOG4107U32 Beta-lactamase domain protein EI545_RS13350 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EI545_RS13355 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EI545_RS13370 ENOG4105E09 nadh pyrophosphatase EI545_RS13380 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EI545_RS13385 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EI545_RS13395 ENOG4108ZNX Heat shock protein EI545_RS13410 ENOG4107RIQ Sulfate adenylate transferase EI545_RS13415 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EI545_RS13420 ENOG4105CN1 protease EI545_RS13430 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EI545_RS13435 ENOG4108SXK Transporter Drug Metabolite Exporter family EI545_RS13455 ENOG4108MP3 ABC transporter, permease EI545_RS13460 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS13465 ENOG4105CQB FAD linked oxidase domain protein EI545_RS13490 ENOG4105C0H protease EI545_RS13495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EI545_RS13500 ENOG4105GR3 Histidine kinase EI545_RS13515 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap EI545_RS13530 ENOG4105CWC Acetylornithine deacetylase EI545_RS13535 ENOG4108XC3 NADH ubiquinone oxidoreductase EI545_RS13540 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) EI545_RS13545 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) EI545_RS13555 ENOG4105C0B DNA polymerase III (alpha subunit) EI545_RS13560 ENOG4105CVE Lytic murein transglycosylase EI545_RS13565 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EI545_RS13580 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EI545_RS13610 ENOG4105T0Z Conserved Protein EI545_RS13615 ENOG4105CKD glutathione-regulated potassium-efflux system protein EI545_RS13620 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EI545_RS13645 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EI545_RS13655 ENOG41077A9 carbonic anhydrase EI545_RS13680 ENOG4105DCM major facilitator superfamily EI545_RS13685 ENOG4105CG3 alpha amylase, catalytic region EI545_RS13695 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein EI545_RS13700 ENOG4108RTU Aldolase EI545_RS13705 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 EI545_RS13710 ENOG4105FGE Short-chain dehydrogenase reductase Sdr EI545_RS13720 ENOG4105DRS transport system, permease EI545_RS13735 ENOG4107HP6 Transcriptional regulator EI545_RS13745 ENOG4105C3M thioredoxin reductase EI545_RS13750 ENOG4105F7P transcriptional regulator AsnC family EI545_RS13760 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EI545_RS13770 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EI545_RS13800 ENOG4105UIB (ABC) transporter EI545_RS13805 ENOG4108JQ9 ABC transporter EI545_RS13810 ENOG4105DIH basic membrane EI545_RS13820 ENOG41072GX Peptidase M22 Glycoprotease EI545_RS13825 ENOG41083MR nifu domain-containing protein EI545_RS13835 ENOG4105DIJ Phosphoethanolamine transferase EI545_RS13845 ENOG4107R73 Mate efflux family protein EI545_RS13875 ENOG4105CSU acyl-Coa dehydrogenase EI545_RS13890 ENOG4105CHU acetyl-coa acetyltransferase EI545_RS13915 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EI545_RS13925 ENOG4108Z7R Chaperone CsaA EI545_RS13930 ENOG4105II7 pyrroline-5-carboxylate reductase EI545_RS13940 ENOG4105C31 Tryptophanyl-tRNA synthetase EI545_RS13950 ENOG4105CJR Integral membrane protein (MviN EI545_RS13955 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) EI545_RS13965 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EI545_RS13985 ENOG4105C0P Mg chelatase subunit ChlI EI545_RS14020 ENOG4105D06 uba thif-type nad fad binding protein EI545_RS14030 ENOG4107R0W ABC transporter EI545_RS14035 ENOG4105E5Q amino acid AbC transporter EI545_RS14040 ENOG4105DGW oligopeptidase A EI545_RS14050 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme EI545_RS14055 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) EI545_RS14060 ENOG4105C1G acyl-Coa dehydrogenase EI545_RS14070 ENOG4105E39 Enoyl-CoA hydratase EI545_RS14085 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) EI545_RS14090 ENOG4105CBG Sulfatase EI545_RS14100 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) EI545_RS14115 ENOG4107QJE Chromosome Partitioning Protein EI545_RS14160 ENOG4105GRZ Ycii-related protein EI545_RS14175 ENOG4108Z2U ureidoglycolate hydrolase EI545_RS14180 ENOG4105S0E allantoin catabolism protein EI545_RS14225 ENOG4105K59 histidine triad (HIT) protein EI545_RS14240 ENOG4105C2M dna polymerase I EI545_RS14255 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EI545_RS14265 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EI545_RS14295 ENOG4105D3Q Sugar transferase EI545_RS14320 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EI545_RS14360 ENOG4106S2D Transcriptional regulator EI545_RS14370 ENOG4105BZU Histidine kinase EI545_RS14380 ENOG4105EU8 FAD linked oxidase domain protein EI545_RS14385 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EI545_RS14400 ENOG4108ZNX Heat shock protein EI545_RS14405 ENOG4105CP2 von willebrand factor, type a EI545_RS14435 ENOG4105CYM Glutathione S-transferase EI545_RS14440 ENOG4105C26 Dehydrogenase EI545_RS14455 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) EI545_RS14460 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EI545_RS14475 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EI545_RS14480 ENOG4105CD3 dihydroorotase EI545_RS14500 ENOG4108UN4 phage SPO1 DNA polymerase-related protein EI545_RS14505 ENOG410829K Lysine exporter protein (Lyse ygga) EI545_RS14510 ENOG4105EPU Molybdenum cofactor synthesis domain protein EI545_RS14530 ENOG4108UJU UPF0301 protein EI545_RS14540 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EI545_RS14545 ENOG4105KJM monovalent cation h antiporter subunit g EI545_RS14560 ENOG4107R4Z monovalent cation h antiporter subunit d EI545_RS14565 ENOG4108ZE9 Monovalent cation H antiporter subunit C EI545_RS14570 ENOG4105D65 subunit l EI545_RS14575 ENOG4105C2J ABC transporter EI545_RS14580 ENOG4105CNN ABC, transporter EI545_RS14585 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator EI545_RS14655 ENOG4105DVW rieske (2Fe-2S) EI545_RS14665 ENOG4105CFQ glutamine synthetase EI545_RS14690 ENOG4105DUM transcriptional regulator, lysR family EI545_RS14695 ENOG4105K6H D-cysteine desulfhydrase EI545_RS14710 ENOG4106FTQ Taurine ABC transporter, periplasmic EI545_RS14715 ENOG4108IY8 ABC, transporter EI545_RS14720 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EI545_RS14730 ENOG4105HMI Membrane EI545_RS14745 ENOG4105F8J Adenylate Guanylate cyclase EI545_RS14755 ENOG4107QPH glycogen) synthase EI545_RS14760 ENOG4107QQG Dehydrogenase EI545_RS14770 ENOG4105CVJ phosphoglycerate mutase EI545_RS14780 ENOG4105DEF Extracellular solute-binding protein, family 5 EI545_RS14790 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EI545_RS14800 ENOG4108I69 Glycosyl transferases group 1 EI545_RS14810 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EI545_RS14835 ENOG4105EVH UPF0753 protein EI545_RS14845 ENOG4105DUM transcriptional regulator, lysR family EI545_RS14850 ENOG4105DU1 integral membrane protein, terc EI545_RS14860 ENOG4108Z9Z response to DNA damage stimulus EI545_RS14875 ENOG4107YCY Transcriptional regulator EI545_RS14880 ENOG4105D4B ABC, transporter EI545_RS14885 ENOG4105C2J ABC transporter EI545_RS14890 ENOG4108HWW ABC transporter EI545_RS14895 ENOG4105CNN ABC, transporter EI545_RS14925 ENOG4105K64 Glycosyl transferase, family 2 EI545_RS14930 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) EI545_RS14940 ENOG4105C5R Aminotransferase EI545_RS14945 ENOG4105CXK mandelate racemase muconate lactonizing EI545_RS14950 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EI545_RS14960 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EI545_RS14975 ENOG4105DRR Transcriptional regulator, GntR family EI545_RS14985 ENOG4105CEY Amp-dependent synthetase and ligase EI545_RS14990 ENOG4108UZX fmn reductase EI545_RS15010 ENOG4105D7T ABC transporter EI545_RS15035 ENOG4105CKK Glycosyl transferase, family 2 EI545_RS15040 ENOG4105ECQ AraC Family Transcriptional Regulator EI545_RS15065 ENOG4105C3G gtp-binding protein EI545_RS15135 ENOG4108M0I Transcriptional regulator EI545_RS15150 ENOG4105CHU acetyl-coa acetyltransferase EI545_RS15165 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EI545_RS15220 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EI545_RS15235 ENOG4105C9M aspartyl-trna synthetase EI545_RS15250 ENOG4105EEX Two component transcriptional regulator (Winged helix family EI545_RS15280 ENOG4105DGU Histone deacetylase EI545_RS15285 ENOG41084XA UPF0235 protein EI545_RS15315 ENOG41080IJ Diacylglycerol kinase EI545_RS15330 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) EI545_RS15355 ENOG4105C8Y Acetylornithine aminotransferase EI545_RS15375 ENOG4106UW1 Major Facilitator superfamily EI545_RS15380 ENOG4105CQ7 ATP-dependent helicase EI545_RS15385 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EI545_RS15390 ENOG4105DJT lAO AO transport system ATPase EI545_RS15410 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EI545_RS15430 ENOG4105C8V SAICAR synthetase EI545_RS15440 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EI545_RS15450 ENOG4105CEY Amp-dependent synthetase and ligase EI545_RS15455 ENOG4105BZ1 (ABC) transporter EI545_RS15470 ENOG4105F2Z 3-oxoadipate enol-lactonase EI545_RS15485 ENOG4105CXK mandelate racemase muconate lactonizing EI545_RS15505 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EI545_RS15510 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EI545_RS15545 ENOG4105CDW Resistance protein EI545_RS15555 ENOG4105FE9 pseudouridine synthase EI545_RS15560 ENOG4108Z6B deaminase EI545_RS15565 ENOG4107T8T UPF0173 metal-dependent hydrolase EI545_RS15580 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EI545_RS15590 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EI545_RS15605 ENOG4105HFZ Membrane EI545_RS15630 ENOG4105ECY inositol monophosphatase EI545_RS15635 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EI545_RS15650 ENOG4107QUY Guanine deaminase EI545_RS15655 ENOG4105CJW magnesium transporter EI545_RS15660 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EI545_RS15730 ENOG4105E4C Lytic transglycosylase catalytic EI545_RS15770 ENOG4105BZS acriflavin resistance protein EI545_RS15775 ENOG410624X efflux transporter, rnd family, mfp subunit EI545_RS15795 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class EI545_RS15800 ENOG4108J59 Extracellular solute-binding protein, family 5 EI545_RS15805 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EI545_RS15810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EI545_RS15815 ENOG4105C3U ABC transporter EI545_RS15820 ENOG4108JQ7 (ABC) transporter EI545_RS15825 ENOG4108IGT Dipeptidase EI545_RS15830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EI545_RS15855 ENOG4108Z03 MAF-like protein EI545_RS15905 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EI545_RS16010 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) EI545_RS16020 ENOG4105DJ9 glucan biosynthesis protein EI545_RS16030 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EI545_RS16045 ENOG4105C08 Histidine kinase EI545_RS16050 ENOG4105EEX Two component transcriptional regulator (Winged helix family EI545_RS16060 ENOG4105EJC lysr family transcriptional regulator EI545_RS16065 ENOG4105CS1 NAD(P)H quinone oxidoreductase EI545_RS16070 ENOG4108KTG Membrane protein, drug metabolite transporter EI545_RS16075 ENOG4107Y80 Major Facilitator superfamily EI545_RS16095 ENOG4105C30 Nad-dependent epimerase dehydratase EI545_RS16100 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EI545_RS16105 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EI545_RS16120 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EI545_RS16130 ENOG4105DVW rieske (2Fe-2S) EI545_RS16135 ENOG4108HM4 ABC transporter EI545_RS16140 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS16145 ENOG4105F38 ABC transporter, permease EI545_RS16150 ENOG4105D38 putrescine abc transporter EI545_RS16160 ENOG4105CI2 imidazolone-5-propionate hydrolase EI545_RS16165 ENOG4105HF0 Membrane EI545_RS16175 ENOG4105JSC dimethylmenaquinone methyltransferase EI545_RS16185 ENOG4105GVF (ABC) transporter EI545_RS16190 ENOG4105D7T ABC transporter EI545_RS16195 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EI545_RS16205 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EI545_RS16220 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase EI545_RS16230 ENOG41080HT Transcriptional regulator, arsr family EI545_RS16240 ENOG4105F5V trimethylamine methyltransferase EI545_RS16310 ENOG4105CPC Aldo Keto reductase EI545_RS16320 ENOG4108YYC ycei family EI545_RS16330 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EI545_RS16365 ENOG4108R96 Methyltransferase, YaeB family EI545_RS16375 ENOG4105EHI Phosphonate ABC transporter, periplasmic EI545_RS16380 ENOG4105S7S phosphonate abc transporter EI545_RS16390 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EI545_RS16400 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG EI545_RS16420 ENOG4105ENV phosphonate C-P lyase system protein PhnK EI545_RS16425 ENOG4105HRV phosphonate c-p lyase system protein phnl EI545_RS16435 ENOG4108TXN phosphonate metabolism protein EI545_RS16440 ENOG4105FD8 phosphonate metabolism protein PhnM EI545_RS16445 ENOG4105D5U fad dependent oxidoreductase EI545_RS16475 ENOG4105MPN Membrane EI545_RS16485 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EI545_RS16490 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) EI545_RS16495 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EI545_RS16500 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EI545_RS16505 ENOG4107XZX Involved in the transcription termination process (By similarity) EI545_RS16520 ENOG4105E8V Alpha Beta Hydrolase Fold protein EI545_RS16540 ENOG4105VEJ Heat shock protein EI545_RS16545 ENOG4108Z4U Ferredoxin EI545_RS16550 ENOG4108VJ1 Transcriptional regulator (CarD family EI545_RS16565 ENOG41084CK capsule polysaccharide EI545_RS16570 ENOG4107U8J Export protein EI545_RS16575 ENOG4105E12 capsule polysaccharide EI545_RS16580 ENOG4107QI1 Mate efflux family protein EI545_RS16595 ENOG4105CSR polyphosphate kinase 2 EI545_RS16620 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EI545_RS16630 ENOG4105EW9 transcriptional regulator AsnC family EI545_RS16635 ENOG410829K Lysine exporter protein (Lyse ygga) EI545_RS16645 ENOG4106V2I dimethylaminohydrolase EI545_RS16660 ENOG4105C2N RNA methyltransferase TrmH family group 3 EI545_RS16665 ENOG4105K4P CoA-binding domain protein EI545_RS16670 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase EI545_RS16675 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EI545_RS16700 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EI545_RS16715 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EI545_RS16730 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EI545_RS16735 ENOG4105C4R Atp-dependent dna helicase EI545_RS16740 ENOG4105DKK Benzoate EI545_RS16770 ENOG4108IG5 Transcriptional regulator EI545_RS16775 ENOG4107YZH Cell division protein mraZ EI545_RS16780 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EI545_RS16790 ENOG4105CJN penicillin-binding protein EI545_RS16795 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EI545_RS16805 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EI545_RS16825 ENOG4107Z1W Fructose transport system kinase EI545_RS16835 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EI545_RS16890 ENOG4105CPF Cell wall formation (By similarity) EI545_RS16895 ENOG4108UFP Essential cell division protein (By similarity) EI545_RS16900 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EI545_RS16905 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EI545_RS16910 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EI545_RS16915 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EI545_RS16920 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EI545_RS16930 ENOG4105CQB FAD linked oxidase domain protein EI545_RS16935 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I EI545_RS16940 ENOG4105CQZ Histidine kinase EI545_RS16950 ENOG4105C03 ribonuclease EI545_RS16960 ENOG4107QIV Cytochrome c biogenesis protein EI545_RS17000 ENOG4105DHQ Histidine kinase EI545_RS17005 ENOG4105VR9 phosphoribosylformylglycinamidine synthase EI545_RS17010 ENOG4107QPR SAICAR synthetase EI545_RS17035 ENOG4108Q52 Methyltransferase cognate corrinoid protein EI545_RS17060 ENOG4105C9Q fumarate hydratase class II EI545_RS17090 ENOG4107RUE extracellular solute-binding protein family 1 EI545_RS17100 ENOG4105CVP deoxyribo-dipyrimidine photolyase EI545_RS17105 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EI545_RS17115 ENOG41087AY ADP-Ribose pyrophosphatase EI545_RS17130 ENOG4105ETE Transcriptional regulator (LacI family EI545_RS17135 ENOG4108JP0 extracellular solute-binding protein family 1 EI545_RS17145 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EI545_RS17150 ENOG4108IJ9 (ABC) transporter EI545_RS17165 ENOG4107VPB domain protein EI545_RS17170 ENOG4105DSG hydrolase family 43 EI545_RS17180 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EI545_RS17185 ENOG4105D6S protein involved in catabolism of external DNA EI545_RS17200 ENOG4108JEH abc transporter atp-binding protein EI545_RS17205 ENOG4106PMH Extracellular solute-binding protein family 3 EI545_RS17215 ENOG4105DSP amino acid AbC transporter EI545_RS17220 ENOG4106YG3 ABC transporter EI545_RS17225 ENOG4105CFQ glutamine synthetase EI545_RS17230 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EI545_RS17240 ENOG4105CJP fad dependent oxidoreductase EI545_RS17245 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EI545_RS17250 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EI545_RS17285 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EI545_RS17290 ENOG4108UYE Lactoylglutathione lyase EI545_RS17295 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) EI545_RS17310 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EI545_RS17330 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EI545_RS17360 ENOG4105EJQ L-serine dehydratase EI545_RS17365 ENOG4105CYM Glutathione S-transferase EI545_RS17380 ENOG4105E66 phosphoriboisomerase A EI545_RS17395 ENOG4105EPW hflc protein EI545_RS17405 ENOG4105C0H protease EI545_RS17410 ENOG4105C0B DNA polymerase III (alpha subunit) EI545_RS17415 ENOG4107Z7P Ferredoxin EI545_RS17440 ENOG4105Y75 tpr repeat protein EI545_RS17465 ENOG4105DGU Histone deacetylase EI545_RS17470 ENOG4105D2T synthase EI545_RS17500 ENOG4105EGS Mechanosensitive ion channel EI545_RS17505 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EI545_RS17510 ENOG4105C26 Dehydrogenase EI545_RS17515 ENOG4108M8W Monooxygenase EI545_RS17520 ENOG4105MXW flavin reductase domain protein, FMN-binding EI545_RS17525 ENOG4108MXF Alpha Beta Hydrolase EI545_RS17535 ENOG4105FDP GntR family transcriptional regulator EI545_RS17550 ENOG4105ETE Transcriptional regulator (LacI family EI545_RS17570 ENOG4105CHR reductase EI545_RS17580 ENOG4108IJ9 (ABC) transporter EI545_RS17585 ENOG4108JP0 extracellular solute-binding protein family 1 EI545_RS17595 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EI545_RS17600 ENOG4108JP0 extracellular solute-binding protein family 1 EI545_RS17610 ENOG4105E39 Enoyl-CoA hydratase EI545_RS17615 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) EI545_RS17635 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin EI545_RS17640 ENOG4108QV3 biosynthesis protein EI545_RS17660 ENOG4105CEY Amp-dependent synthetase and ligase EI545_RS17660 ENOG4105CEY Amp-dependent synthetase and ligase EI545_RS17665 ENOG4108TSE Transferase EI545_RS17690 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family EI545_RS17700 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EI545_RS17715 ENOG4105D7W serine acetyltransferase EI545_RS17745 ENOG4105BZ1 (ABC) transporter EI545_RS17755 ENOG4105D3Q Sugar transferase EI545_RS17770 ENOG4108ZJ4 polysaccharide deacetylase EI545_RS17790 ENOG4105EMU Dehydrogenase EI545_RS17795 ENOG4105EQ2 LysR family Transcriptional regulator EI545_RS17830 ENOG4107S9F NmrA family EI545_RS17835 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein EI545_RS17840 ENOG4108JGH Tetr family transcriptional regulator EI545_RS17850 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EI545_RS17865 ENOG4107FW0 short-chain dehydrogenase reductase EI545_RS17870 ENOG4108CIP transcriptional regulator EI545_RS17880 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EI545_RS17890 ENOG4105EXG Transcriptional regulator EI545_RS17900 ENOG4108UQ8 endoribonuclease L-psp EI545_RS17910 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EI545_RS17915 ENOG4105C0R drug resistance transporter emrb qaca subfamily EI545_RS17920 ENOG4105HF0 Membrane EI545_RS17935 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EI545_RS17940 ENOG4106FI7 cytochrome c-type biogenesis protein EI545_RS17945 ENOG4105DDR sarcosine oxidase (Beta subunit) EI545_RS17960 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EI545_RS17975 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EI545_RS17995 ENOG4108URH decarboxylase EI545_RS18015 ENOG4108JJ7 ABC transporter EI545_RS18035 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EI545_RS18045 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EI545_RS18050 ENOG4105VIE preprotein translocase, subunit YajC EI545_RS18055 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EI545_RS18060 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EI545_RS18065 ENOG4108UIV Protein of unknown function (DUF498/DUF598) EI545_RS18070 ENOG4105CPC Aldo Keto reductase EI545_RS18075 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) EI545_RS18080 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) EI545_RS18085 ENOG41060IM Heme exporter protein EI545_RS18095 ENOG4107QX9 Thiol disulfide interChange protein EI545_RS18100 ENOG4107QM5 aconitate hydratase EI545_RS18140 ENOG4105C83 adenylosuccinate lyase EI545_RS18150 ENOG4105H1N peptidase, M24 EI545_RS18170 ENOG4105C5F glutamine synthetase EI545_RS18175 ENOG4108YZA Nitrogen regulatory protein pii EI545_RS18195 ENOG4106PBJ Serine threonine-protein kinase Pkn6 EI545_RS18210 ENOG4105CJP fad dependent oxidoreductase EI545_RS18215 ENOG4105CHR reductase EI545_RS18235 ENOG4105CXB phosphoribosylaminoimidazole synthetase EI545_RS18240 ENOG4108V3E phosphoribosylglycinamide formyltransferase EI545_RS18245 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) EI545_RS18255 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) EI545_RS18265 ENOG4107T6F Xaa-Pro aminopeptidase EI545_RS18295 ENOG4105E0X reductase EI545_RS18320 ENOG4107QP3 malate synthase g EI545_RS18325 ENOG4105NPE arsR family transcriptional regulator EI545_RS18345 ENOG4105CVP deoxyribo-dipyrimidine photolyase EI545_RS18350 ENOG4105CD8 aminopeptidase N EI545_RS18365 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EI545_RS18375 ENOG4105CIH Imidazole acetol-phosphate transaminase EI545_RS18380 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EI545_RS18425 ENOG4105BZN citrate synthase EI545_RS18435 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 EI545_RS18440 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EI545_RS18445 ENOG4105CVM Molybdenum cofactor synthesis domain protein EI545_RS18450 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EI545_RS18455 ENOG4105DK0 Indole-3-glycerol phosphate synthase EI545_RS18465 ENOG4105DDQ anthranilate synthase EI545_RS18470 ENOG4105CJT Mannose-1-phosphate guanylyltransferase EI545_RS18480 ENOG4105CPQ Dehydrogenase EI545_RS18485 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EI545_RS18490 ENOG4108JCI Transcriptional regulator EI545_RS18510 ENOG4105VEQ Cold shock protein EI545_RS18515 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EI545_RS18520 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EI545_RS18530 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) EI545_RS18545 ENOG4105CRQ synthase (Component I) EI545_RS18570 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EI545_RS18575 ENOG4108JQ6 ABC transporter EI545_RS18615 ENOG4108X0B nad(p)h dehydrogenase (quinone) EI545_RS18620 ENOG4105DYS nad(p)h dehydrogenase (quinone) EI545_RS18625 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EI545_RS18660 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EI545_RS18670 ENOG4105ECK Fatty Acid Desaturase EI545_RS18675 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EI545_RS18680 ENOG4105HM0 Sulfoacetaldehyde acetyltransferase EI545_RS18695 ENOG4105DB1 molybdopterin oxidoreductase EI545_RS18700 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein EI545_RS18710 ENOG4107QKV phosphomannomutase EI545_RS18715 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) EI545_RS18730 ENOG4105KI2 Urea amidohydrolase subunit beta EI545_RS18755 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) EI545_RS18760 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) EI545_RS18765 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) EI545_RS18770 ENOG4105KNK cytochrome C EI545_RS18775 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EI545_RS18780 ENOG4108TF2 Photosynthetic complex assembly protein 2 EI545_RS18785 ENOG4105FBB Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) EI545_RS18795 ENOG410844H EI545_RS18805 ENOG4108S36 Photosynthetic reaction center EI545_RS18810 ENOG4105XCI PucC protein EI545_RS18815 ENOG4108MIC Mg-protoporphyrin IX methyl transferase EI545_RS18820 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) EI545_RS18825 ENOG4105CTK cobaltochelatase, cobn subunit EI545_RS18830 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) EI545_RS18835 ENOG4105C78 Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) EI545_RS18840 ENOG4108VJI 2-vinyl bacteriochlorophyllide hydratase EI545_RS18845 ENOG41062FI Regulatory protein, PpaA EI545_RS18850 ENOG4105D4D transcriptional regulator EI545_RS18860 ENOG4105I29 Bacteriochlorophyll 4-vinyl reductase EI545_RS18865 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase EI545_RS18870 ENOG4105SS7 PucC protein EI545_RS18875 ENOG4107QZT geranylgeranyl reductase EI545_RS18880 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EI545_RS18885 ENOG41082A2 Alpha beta hydrolase EI545_RS18890 ENOG4107SV1 subunit D EI545_RS18895 ENOG4105EET magnesium chelatase EI545_RS18905 ENOG4105EWK phytoene EI545_RS18910 ENOG4105FE1 phytoene synthase EI545_RS18915 ENOG4105KAV tspo and mbr like protein EI545_RS18920 ENOG4108PZJ hydroxyneurosporene synthase EI545_RS18925 ENOG4107VFM Dehydrogenase EI545_RS18930 ENOG4105CTB Polyprenyl synthetase EI545_RS18935 ENOG4107EPK O-methyltransferase, family 2 EI545_RS18940 ENOG4107XHQ chlorophyll synthesis pathway, bchC EI545_RS18945 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) EI545_RS18950 ENOG41060GA Chlorophyllide reductase subunit Y EI545_RS18955 ENOG4105ETK chlorophyllide reductase subunit Z EI545_RS18965 ENOG4105X2X Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity) EI545_RS18970 ENOG41068GY Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity) EI545_RS18975 ENOG4105VGZ photosynthetic reaction center L subunit EI545_RS18980 ENOG4107R94 photosynthetic reaction center, M subunit EI545_RS18990 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EI545_RS19000 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EI545_RS19020 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EI545_RS19030 ENOG4105BZ1 (ABC) transporter EI545_RS19035 ENOG4105C5R Aminotransferase EI545_RS19045 ENOG4108Z86 Glutamine amidotransferase EI545_RS19050 ENOG4108JU6 CBS domain protein EI545_RS19055 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EI545_RS19065 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EI545_RS19075 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 EI545_RS19115 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr EI545_RS19120 ENOG4105CHR reductase EI545_RS19125 ENOG4105H1N peptidase, M24 EI545_RS19130 ENOG4105CHR reductase EI545_RS19140 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EI545_RS19145 ENOG4105CHR reductase EI545_RS19150 ENOG4105CNN ABC, transporter EI545_RS19155 ENOG4105CNN ABC, transporter EI545_RS19160 ENOG4105C2J ABC transporter EI545_RS19175 ENOG4108JJ6 Type I secretion system ATPase EI545_RS19185 ENOG4107SM8 Adenylate Guanylate cyclase EI545_RS19225 ENOG4105BZS acriflavin resistance protein EI545_RS19235 ENOG4105CI2 imidazolone-5-propionate hydrolase EI545_RS19260 ENOG4105BZU Histidine kinase EI545_RS19265 ENOG4108KXV response regulator EI545_RS19280 ENOG4105DHJ ABC, transporter EI545_RS19285 ENOG4105CY3 ABC transporter, permease EI545_RS19310 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) EI545_RS19325 ENOG4107RUE extracellular solute-binding protein family 1 EI545_RS19330 ENOG4105D38 putrescine abc transporter EI545_RS19335 ENOG4105F38 ABC transporter, permease EI545_RS19340 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS19345 ENOG4108UDW Transcriptional regulator, luxr family EI545_RS19355 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EI545_RS19365 ENOG4105C8U phosphate abc transporter EI545_RS19380 ENOG4105C26 Dehydrogenase EI545_RS19405 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EI545_RS19410 ENOG4105CGH 5'-nucleotidase EI545_RS19420 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EI545_RS19430 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EI545_RS19435 ENOG4108YYC ycei family EI545_RS19440 ENOG4105DS1 cytochrome b561 EI545_RS19445 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EI545_RS19455 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EI545_RS19460 ENOG4105CYW agmatinase EI545_RS19465 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EI545_RS19470 ENOG4105HHA aminodeoxychorismate lyase EI545_RS19560 ENOG4105D7W serine acetyltransferase EI545_RS19570 ENOG4108HPI phosphatidate Cytidylyltransferase EI545_RS19580 ENOG4105C7S Dehydrogenase EI545_RS19585 ENOG4105CPP Dehydrogenase, E1 component EI545_RS19590 ENOG4108JYK Dehydrogenase EI545_RS19600 ENOG4105WYW fructose-bisphosphate aldolase EI545_RS19605 ENOG4105BZA Phosphoglycerate kinase EI545_RS19625 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EI545_RS19630 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) EI545_RS19635 ENOG4105FR1 rard protein EI545_RS19650 ENOG4108R99 pseudouridine synthase EI545_RS19665 ENOG4107RTZ reductase EI545_RS19695 ENOG4108VHT MarR family transcriptional regulator EI545_RS19705 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding EI545_RS19755 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EI545_RS19760 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EI545_RS19775 ENOG4105NAE bifunctional deaminase-reductase domain protein EI545_RS19790 ENOG4105EUB pirin domain protein EI545_RS19820 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EI545_RS19830 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EI545_RS19840 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase EI545_RS19850 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) EI545_RS19865 ENOG4105C57 major facilitator superfamily EI545_RS19875 ENOG4105DR5 peptidase EI545_RS19880 ENOG4105ED9 Protein of unknown function (DUF455) EI545_RS19885 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EI545_RS19895 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EI545_RS19910 ENOG4107QN2 dihydrolipoyl dehydrogenase EI545_RS19935 ENOG4105C26 Dehydrogenase EI545_RS19940 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EI545_RS19955 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EI545_RS19960 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EI545_RS19965 ENOG4105CKW Inner membrane protein yedI EI545_RS19980 ENOG4105CV1 Transketolase (EC 2.2.1.1) EI545_RS19995 ENOG41069B0 Membrane-bound lysozyme-inhibitor of c-type lysozyme EI545_RS20000 ENOG4105M2J Glutaredoxin EI545_RS20025 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EI545_RS20030 ENOG4105GRZ Ycii-related protein EI545_RS20035 ENOG4105CHP RNA polymerase EI545_RS20045 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EI545_RS20055 ENOG4105TMB Formate nitrite transporter EI545_RS20065 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) EI545_RS20070 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EI545_RS20075 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) EI545_RS20090 ENOG4105C75 arginyL-tRNA synthetase EI545_RS20105 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EI545_RS20110 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EI545_RS20120 ENOG4105DHP deoxycytidine triphosphate deaminase EI545_RS20130 ENOG4105WJX transcriptional regulator MERR family EI545_RS20140 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EI545_RS20145 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EI545_RS20150 ENOG41082R8 50S ribosomal protein l32 EI545_RS20165 ENOG4105E0X reductase EI545_RS20185 ENOG4105DAE Methylenetetrahydrofolate reductase EI545_RS20195 ENOG4105C9X ppx gppa phosphatase EI545_RS20215 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EI545_RS20235 ENOG4105D7A ATP-binding protein EI545_RS20240 ENOG4108IG5 Transcriptional regulator EI545_RS20245 ENOG4107QI1 Mate efflux family protein EI545_RS20260 ENOG4105KME endoribonuclease L-psp EI545_RS20275 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EI545_RS20280 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EI545_RS20300 ENOG4107R16 Multicopper oxidase EI545_RS20315 ENOG4105E0F Histidine kinase EI545_RS20320 ENOG4105ENT Efflux transporter rnd family, mfp subunit EI545_RS20370 ENOG4108PXI ErfK YbiS YcfS YnhG EI545_RS20405 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) EI545_RS20410 ENOG4105CJN penicillin-binding protein EI545_RS20415 ENOG4105NP4 Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis (By similarity) EI545_RS20420 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EI545_RS20460 ENOG4107R16 Multicopper oxidase EI545_RS20465 ENOG4107ZT5 Thiol disulfide interchange protein EI545_RS20480 ENOG4108ZX6 Electron transport protein SCO1 SenC EI545_RS20490 ENOG4108ZX6 Electron transport protein SCO1 SenC EI545_RS20495 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EI545_RS20505 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EI545_RS20510 ENOG4105KST dependent repressor EI545_RS20515 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EI545_RS20535 ENOG4105C59 p-type ATPase EI545_RS20540 ENOG4105W1Y Transcriptional regulator EI545_RS20565 ENOG4108IJF Heavy metal efflux pump, CzcA EI545_RS20615 ENOG4105E4C Lytic transglycosylase catalytic EI545_RS20650 ENOG4108EHY type IV secretion system EI545_RS20750 ENOG4105C26 Dehydrogenase EI545_RS20795 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI545_RS20810 ENOG4105EW9 transcriptional regulator AsnC family EI545_RS20870 ENOG4105W5Q DNA repair protein (RadC EI545_RS20915 ENOG4105FEQ ParB domain protein nuclease EI545_RS20945 ENOG4105E0F Histidine kinase EI545_RS20995 ENOG4105H3G oxidoreductase EI545_RS21090 ENOG4107QVI Methyltransferase, type 11 EI545_RS21095 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein EI545_RS21105 ENOG4107SQD Transcriptional regulator, GntR family EI545_RS21110 ENOG4105DUM transcriptional regulator, lysR family EI545_RS21135 ENOG41082AG Plasmid maintenance system antidote protein EI545_RS21190 ENOG4108EHX EamA-like transporter family EI545_RS21195 ENOG410880H cysteine synthase EI545_RS21200 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EI545_RS21240 ENOG4108C33 Resolvase EI545_RS21285 ENOG4105CHU acetyl-coa acetyltransferase