locus-tag	class	description
C1A40_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1A40_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1A40_RS00015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1A40_RS00025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1A40_RS00035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1A40_RS00040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1A40_RS00060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1A40_RS00070	COG0242	peptide deformylase activity
C1A40_RS00075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1A40_RS00095	COG1216	Glycosyl transferase, family 2
C1A40_RS00145	COG0009	L-threonylcarbamoyladenylate synthase
C1A40_RS00155	COG0617	tRNA 3'-terminal CCA addition
C1A40_RS00155	COG0517	IMP dehydrogenase activity
C1A40_RS00155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1A40_RS00160	COG1612	heme a metabolic process
C1A40_RS00195	COG0556	nucleotide-excision repair
C1A40_RS00220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C1A40_RS00225	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1A40_RS00255	COG2017	converts alpha-aldose to the beta-anomer
C1A40_RS00260	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1A40_RS00265	COG1085	galactose-1-phosphate uridylyltransferase
C1A40_RS00280	COG0655	NAD(P)H dehydrogenase (quinone) activity
C1A40_RS00285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1A40_RS00295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1A40_RS00300	COG2105	PFAM AIG2 family protein
C1A40_RS00310	COG0542	response to heat
C1A40_RS00315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1A40_RS00320	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1A40_RS00325	COG0813	purine-nucleoside phosphorylase activity
C1A40_RS00330	COG0702	epimerase
C1A40_RS00335	COG4771	TonB-dependent receptor
C1A40_RS00345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C1A40_RS00375	COG0606	chelatase, subunit chli
C1A40_RS00385	COG1116	anion transmembrane transporter activity
C1A40_RS00390	COG1116	anion transmembrane transporter activity
C1A40_RS00395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1A40_RS00400	COG1116	anion transmembrane transporter activity
C1A40_RS00400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1A40_RS00410	COG0543	2 iron, 2 sulfur cluster binding
C1A40_RS00410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1A40_RS00440	COG0437	4 iron, 4 sulfur cluster binding
C1A40_RS00455	COG0243	molybdopterin cofactor binding
C1A40_RS00465	COG0303	'Molybdopterin
C1A40_RS00490	COG0746	molybdenum cofactor guanylyltransferase activity
C1A40_RS00500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1A40_RS00515	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1A40_RS00515	COG0315	cyclic pyranopterin monophosphate synthase activity
C1A40_RS00530	COG0012	GTP binding
C1A40_RS00540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1A40_RS00550	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1A40_RS00555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1A40_RS00585	COG4771	TonB-dependent receptor
C1A40_RS00590	COG0517	IMP dehydrogenase activity
C1A40_RS00590	COG0516	GMP reductase activity
C1A40_RS00625	COG0167	dihydroorotate dehydrogenase activity
C1A40_RS00630	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1A40_RS00635	COG4574	serine-type endopeptidase inhibitor activity
C1A40_RS00650	COG3328	transposase activity
C1A40_RS00665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1A40_RS00670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1A40_RS00685	COG1862	Preprotein translocase
C1A40_RS00695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1A40_RS00700	COG1132	(ABC) transporter
C1A40_RS00715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1A40_RS00725	COG1247	-acetyltransferase
C1A40_RS00735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1A40_RS00740	COG0514	ATP-dependent DNA helicase (RecQ)
C1A40_RS00750	COG0805	protein transport
C1A40_RS00775	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS00780	COG2354	Protein conserved in bacteria
C1A40_RS00785	COG1183	phosphatidylcholine synthase activity
C1A40_RS00800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1A40_RS00900	COG2089	acid synthase
C1A40_RS00910	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C1A40_RS00955	COG1216	Glycosyl transferase, family 2
C1A40_RS00965	COG1216	Glycosyl transferase, family 2
C1A40_RS00970	COG0463	Glycosyl transferase, family 2
C1A40_RS00980	COG0438	transferase activity, transferring glycosyl groups
C1A40_RS01010	COG0489	protein tyrosine kinase activity
C1A40_RS01020	COG0488	(ABC) transporter
C1A40_RS01035	COG1228	amidohydrolase
C1A40_RS01040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1A40_RS01045	COG2986	histidine ammonia-lyase
C1A40_RS01050	COG0583	DNA-binding transcription factor activity
C1A40_RS01070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1A40_RS01180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1A40_RS01185	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1A40_RS01190	COG0406	alpha-ribazole phosphatase activity
C1A40_RS01210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1A40_RS01215	COG1120	ATPase activity
C1A40_RS01245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1A40_RS01250	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1A40_RS01275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1A40_RS01300	COG0254	rRNA binding
C1A40_RS01310	COG0463	Glycosyl transferase, family 2
C1A40_RS01315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1A40_RS01320	COG1132	(ABC) transporter
C1A40_RS01325	COG1595	DNA-templated transcription, initiation
C1A40_RS01345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1A40_RS01345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1A40_RS01350	COG3385	transposase activity
C1A40_RS01355	COG1960	acyl-CoA dehydrogenase activity
C1A40_RS01365	COG0183	Belongs to the thiolase family
C1A40_RS01370	COG1024	Enoyl-CoA hydratase
C1A40_RS01370	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1A40_RS01375	COG1846	Transcriptional regulator
C1A40_RS01415	COG1484	DNA-dependent DNA replication
C1A40_RS01420	COG3385	transposase activity
C1A40_RS01455	COG3328	transposase activity
C1A40_RS01475	COG0268	Binds directly to 16S ribosomal RNA
C1A40_RS01485	COG0442	prolyl-tRNA aminoacylation
C1A40_RS01500	COG0302	gtp cyclohydrolase
C1A40_RS01505	COG0215	cysteine-tRNA ligase activity
C1A40_RS01510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1A40_RS01530	COG3385	transposase activity
C1A40_RS01540	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1A40_RS01560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1A40_RS01565	COG0501	Belongs to the peptidase M48B family
C1A40_RS01570	COG2885	chlorophyll binding
C1A40_RS01585	COG0653	protein targeting
C1A40_RS01630	COG0037	tRNA processing
C1A40_RS01635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1A40_RS01640	COG0552	protein localization to endoplasmic reticulum
C1A40_RS01650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1A40_RS01655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1A40_RS01660	COG1058	Belongs to the CinA family
C1A40_RS01660	COG1546	Belongs to the CinA family
C1A40_RS01670	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1A40_RS01675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1A40_RS01685	COG1342	Belongs to the UPF0251 family
C1A40_RS01690	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1A40_RS01700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1A40_RS01705	COG4145	pantothenate transmembrane transporter activity
C1A40_RS01720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1A40_RS01725	COG0326	Molecular chaperone. Has ATPase activity
C1A40_RS01740	COG2258	MOSC domain
C1A40_RS01755	COG0513	Belongs to the DEAD box helicase family
C1A40_RS01760	COG3385	transposase activity
C1A40_RS01770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1A40_RS01785	COG3743	rRNA binding
C1A40_RS01785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1A40_RS01800	COG1584	GPR1 FUN34 yaaH family protein
C1A40_RS01810	COG0321	lipoyl(octanoyl) transferase activity
C1A40_RS01820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1A40_RS01825	COG0366	Alpha amylase catalytic
C1A40_RS01835	COG0366	Alpha amylase catalytic
C1A40_RS01840	COG1082	Xylose isomerase domain protein TIM barrel
C1A40_RS01845	COG1554	hydrolase, family 65, central catalytic
C1A40_RS01850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1A40_RS01855	COG2190	(PTS) system
C1A40_RS01855	COG2211	Major facilitator Superfamily
C1A40_RS01860	COG1609	Transcriptional regulator
C1A40_RS01865	COG1629	transport
C1A40_RS01865	COG4206	TonB-dependent receptor
C1A40_RS01870	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C1A40_RS01880	COG0366	Alpha amylase catalytic
C1A40_RS01905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1A40_RS01910	COG1388	LysM domain
C1A40_RS01910	COG1705	Flagellar rod assembly protein muramidase FlgJ
C1A40_RS01915	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C1A40_RS01940	COG3328	transposase activity
C1A40_RS01965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1A40_RS01970	COG0739	heme binding
C1A40_RS02005	COG1160	GTP binding
C1A40_RS02015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1A40_RS02030	COG3385	transposase activity
C1A40_RS02065	COG2755	lipolytic protein G-D-S-L family
C1A40_RS02070	COG4677	pectinesterase activity
C1A40_RS02090	COG4771	TonB-dependent receptor
C1A40_RS02095	COG0702	epimerase
C1A40_RS02120	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C1A40_RS02145	COG1629	transport
C1A40_RS02155	COG2721	sulfolactate sulfo-lyase activity
C1A40_RS02160	COG0246	Mannitol dehydrogenase
C1A40_RS02170	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS02175	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C1A40_RS02190	COG1874	Beta-galactosidase
C1A40_RS02195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C1A40_RS02200	COG1472	Belongs to the glycosyl hydrolase 3 family
C1A40_RS02205	COG1501	Belongs to the glycosyl hydrolase 31 family
C1A40_RS02215	COG0561	phosphatase activity
C1A40_RS02220	COG4771	TonB-dependent receptor
C1A40_RS02255	COG0714	Associated with various cellular activities
C1A40_RS02275	COG2304	oxidoreductase activity
C1A40_RS02500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1A40_RS02505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1A40_RS02510	COG2205	protein histidine kinase activity
C1A40_RS02510	COG0784	Response regulator, receiver
C1A40_RS02515	COG1663	tetraacyldisaccharide 4'-kinase activity
C1A40_RS02520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1A40_RS02545	COG3844	kynureninase activity
C1A40_RS02550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1A40_RS02565	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS02595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1A40_RS02620	COG3385	transposase activity
C1A40_RS02625	COG3340	Belongs to the peptidase S51 family
C1A40_RS02655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1A40_RS02665	COG0427	acetyl-CoA hydrolase
C1A40_RS02685	COG4628	conserved protein (DUF2132)
C1A40_RS02695	COG0513	Belongs to the DEAD box helicase family
C1A40_RS02720	COG3022	response to hydroperoxide
C1A40_RS02725	COG1242	4 iron, 4 sulfur cluster binding
C1A40_RS02780	COG0714	Associated with various cellular activities
C1A40_RS02790	COG0783	Belongs to the Dps family
C1A40_RS02805	COG1858	cytochrome C peroxidase
C1A40_RS03125	COG1312	Catalyzes the dehydration of D-mannonate
C1A40_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS03155	COG3385	transposase activity
C1A40_RS03180	COG1253	flavin adenine dinucleotide binding
C1A40_RS03205	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C1A40_RS03225	COG3385	transposase activity
C1A40_RS03240	COG1012	belongs to the aldehyde dehydrogenase family
C1A40_RS03285	COG2133	pyrroloquinoline quinone binding
C1A40_RS03305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1A40_RS03315	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1A40_RS03315	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1A40_RS03320	COG1192	Involved in chromosome partitioning
C1A40_RS03325	COG1475	DNA binding
C1A40_RS03335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1A40_RS03340	COG0681	Belongs to the peptidase S26 family
C1A40_RS03370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1A40_RS03385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1A40_RS03395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1A40_RS03405	COG1278	Cold shock
C1A40_RS03410	COG0105	UTP biosynthetic process
C1A40_RS03415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1A40_RS03425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1A40_RS03430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1A40_RS03450	COG3119	arylsulfatase activity
C1A40_RS03460	COG3385	transposase activity
C1A40_RS03475	COG0187	DNA topoisomerase II activity
C1A40_RS03490	COG0154	amidase activity
C1A40_RS03495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1A40_RS03515	COG3850	Histidine kinase
C1A40_RS03515	COG5002	protein histidine kinase activity
C1A40_RS03520	COG3385	transposase activity
C1A40_RS03535	COG0602	queuosine metabolic process
C1A40_RS03540	COG0433	COG0433 Predicted ATPase
C1A40_RS03550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C1A40_RS03555	COG0662	Cupin 2, conserved barrel domain protein
C1A40_RS03555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1A40_RS03565	COG1187	pseudouridine synthase activity
C1A40_RS03570	COG0583	DNA-binding transcription factor activity
C1A40_RS03590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1A40_RS03600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1A40_RS03620	COG0018	arginyl-trna synthetase
C1A40_RS03625	COG4251	negative regulation of phosphorylation
C1A40_RS03665	COG0372	Belongs to the citrate synthase family
C1A40_RS03670	COG0148	phosphopyruvate hydratase activity
C1A40_RS03675	COG0505	Belongs to the CarA family
C1A40_RS03680	COG0203	ribosomal protein L17
C1A40_RS03685	COG0202	RNA polymerase activity
C1A40_RS03690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1A40_RS03695	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1A40_RS03700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1A40_RS03705	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1A40_RS03710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1A40_RS03720	COG0200	Binds to the 23S rRNA
C1A40_RS03725	COG1841	ribosomal large subunit assembly
C1A40_RS03730	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1A40_RS03735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1A40_RS03740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1A40_RS03745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1A40_RS03750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1A40_RS03755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1A40_RS03760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1A40_RS03765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1A40_RS03770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1A40_RS03775	COG0255	Belongs to the universal ribosomal protein uL29 family
C1A40_RS03780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1A40_RS03785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1A40_RS03790	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1A40_RS03795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1A40_RS03800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1A40_RS03805	COG0089	rRNA binding
C1A40_RS03810	COG0088	Forms part of the polypeptide exit tunnel
C1A40_RS03815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1A40_RS03820	COG0051	transcription antitermination factor activity, RNA binding
C1A40_RS03825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1A40_RS03830	COG0049	tRNA binding
C1A40_RS03835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1A40_RS03845	COG1629	transport
C1A40_RS03850	COG0561	phosphatase activity
C1A40_RS03855	COG1629	transport
C1A40_RS03875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1A40_RS03885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1A40_RS03900	COG2003	Belongs to the UPF0758 family
C1A40_RS03905	COG3385	transposase activity
C1A40_RS03915	COG1196	nuclear chromosome segregation
C1A40_RS03915	COG3264	Mechanosensitive ion channel
C1A40_RS03920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1A40_RS03930	COG4206	TonB-dependent receptor
C1A40_RS03930	COG1629	transport
C1A40_RS03945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1A40_RS03950	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS03965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1A40_RS03970	COG0563	adenylate kinase activity
C1A40_RS03975	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1A40_RS03980	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1A40_RS03985	COG0339	signal peptide processing
C1A40_RS04005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1A40_RS04005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1A40_RS04010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1A40_RS04030	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
C1A40_RS04035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1A40_RS04040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1A40_RS04065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1A40_RS04080	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1A40_RS04085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1A40_RS04090	COG0295	cytidine deaminase activity
C1A40_RS04110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1A40_RS04130	COG2166	iron-sulfur cluster assembly
C1A40_RS04135	COG2151	metal-sulfur cluster biosynthetic enzyme
C1A40_RS04150	COG3385	transposase activity
C1A40_RS04155	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1A40_RS04160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1A40_RS04170	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C1A40_RS04230	COG4771	TonB-dependent receptor
C1A40_RS04235	COG0166	Belongs to the GPI family
C1A40_RS04245	COG3483	tryptophan 2,3-dioxygenase activity
C1A40_RS04255	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1A40_RS04260	COG0322	excinuclease ABC activity
C1A40_RS04265	COG4067	protein conserved in archaea
C1A40_RS04265	COG0189	ligase activity
C1A40_RS04270	COG0189	ligase activity
C1A40_RS04280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1A40_RS04290	COG3385	transposase activity
C1A40_RS04305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1A40_RS04315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1A40_RS04320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1A40_RS04335	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C1A40_RS04340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1A40_RS04345	COG0297	glycogen (starch) synthase activity
C1A40_RS04355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1A40_RS04360	COG4771	TonB-dependent receptor
C1A40_RS04385	COG3123	guanosine phosphorylase activity
C1A40_RS04395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1A40_RS04410	COG2095	MarC family integral membrane protein
C1A40_RS04425	COG0793	Belongs to the peptidase S41A family
C1A40_RS04440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1A40_RS04460	COG1484	DNA-dependent DNA replication
C1A40_RS04495	COG0629	single-stranded DNA binding
C1A40_RS04500	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1A40_RS04505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1A40_RS04520	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1A40_RS04525	COG0004	ammonium transporteR
C1A40_RS04530	COG0347	Belongs to the P(II) protein family
C1A40_RS04535	COG0004	ammonium transporteR
C1A40_RS04545	COG0070	glutamate synthase
C1A40_RS04545	COG0069	glutamate synthase activity
C1A40_RS04545	COG0067	glutamate synthase
C1A40_RS04560	COG3385	transposase activity
C1A40_RS04565	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C1A40_RS04575	COG0527	aspartate kinase activity
C1A40_RS04595	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS04605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1A40_RS04610	COG2205	protein histidine kinase activity
C1A40_RS04610	COG0745	RESPONSE REGULATOR receiver
C1A40_RS04610	COG3292	Two component regulator propeller
C1A40_RS04615	COG4771	TonB-dependent receptor
C1A40_RS04620	COG0702	epimerase
C1A40_RS04630	COG3386	PFAM SMP-30 Gluconolaconase
C1A40_RS04635	COG1472	Belongs to the glycosyl hydrolase 3 family
C1A40_RS04650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1A40_RS04655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1A40_RS04660	COG0193	aminoacyl-tRNA hydrolase activity
C1A40_RS04665	COG3328	transposase activity
C1A40_RS04675	COG1715	Restriction endonuclease
C1A40_RS04685	COG0196	riboflavin kinase activity
C1A40_RS04695	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1A40_RS04710	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1A40_RS04715	COG2239	Acts as a magnesium transporter
C1A40_RS04720	COG1561	YicC-like family, N-terminal region
C1A40_RS04725	COG0194	GDP metabolic process
C1A40_RS04730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1A40_RS04745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1A40_RS04755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1A40_RS04765	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1A40_RS04770	COG1950	PFAM Membrane protein of
C1A40_RS04775	COG0596	Alpha beta hydrolase
C1A40_RS04780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1A40_RS04790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1A40_RS04800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1A40_RS04820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1A40_RS04825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1A40_RS04835	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1A40_RS04845	COG0668	transmembrane transport
C1A40_RS04860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A40_RS04865	COG1136	(ABC) transporter
C1A40_RS04865	COG0577	efflux transmembrane transporter activity
C1A40_RS04870	COG0577	efflux transmembrane transporter activity
C1A40_RS04875	COG1136	(ABC) transporter
C1A40_RS04885	COG2322	membrane
C1A40_RS04890	COG1999	signal sequence binding
C1A40_RS04905	COG1845	cytochrome c oxidase, subunit III
C1A40_RS04910	COG1845	cytochrome c oxidase, subunit III
C1A40_RS04915	COG0109	protoheme IX farnesyltransferase activity
C1A40_RS04940	COG0509	glycine decarboxylation via glycine cleavage system
C1A40_RS04950	COG0632	four-way junction helicase activity
C1A40_RS04955	COG0280	phosphate acetyltransferase
C1A40_RS04955	COG0281	malic enzyme
C1A40_RS04960	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1A40_RS04970	COG2255	four-way junction helicase activity
C1A40_RS04975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1A40_RS04980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1A40_RS05005	COG0437	4 iron, 4 sulfur cluster binding
C1A40_RS05030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1A40_RS05035	COG0195	Participates in both transcription termination and antitermination
C1A40_RS05040	COG0779	Required for maturation of 30S ribosomal subunits
C1A40_RS05070	COG1408	metallophosphoesterase
C1A40_RS05075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1A40_RS05075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1A40_RS05090	COG1061	Type III restriction enzyme res subunit
C1A40_RS05110	COG1484	DNA-dependent DNA replication
C1A40_RS05130	COG0205	6-phosphofructokinase activity
C1A40_RS05140	COG1609	Transcriptional regulator
C1A40_RS05145	COG3250	beta-galactosidase activity
C1A40_RS05165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C1A40_RS05170	COG4206	TonB-dependent receptor
C1A40_RS05170	COG1629	transport
C1A40_RS05175	COG3292	Two component regulator propeller
C1A40_RS05175	COG2205	protein histidine kinase activity
C1A40_RS05175	COG0745	RESPONSE REGULATOR receiver
C1A40_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS05185	COG2271	Major facilitator Superfamily
C1A40_RS05190	COG2186	Transcriptional regulator
C1A40_RS05215	COG1629	transport
C1A40_RS05235	COG3420	alginic acid biosynthetic process
C1A40_RS05240	COG3420	alginic acid biosynthetic process
C1A40_RS05250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1A40_RS05275	COG3328	transposase activity
C1A40_RS05325	COG4974	Belongs to the 'phage' integrase family
C1A40_RS05330	COG4974	Belongs to the 'phage' integrase family
C1A40_RS05500	COG1401	restriction endodeoxyribonuclease activity
C1A40_RS05515	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1A40_RS05635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1A40_RS05655	COG1428	Deoxynucleoside kinase
C1A40_RS05670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1A40_RS05675	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1A40_RS05695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1A40_RS05720	COG0659	secondary active sulfate transmembrane transporter activity
C1A40_RS05735	COG0288	reversible hydration of carbon dioxide
C1A40_RS05740	COG0659	secondary active sulfate transmembrane transporter activity
C1A40_RS05765	COG2304	oxidoreductase activity
C1A40_RS05770	COG2304	oxidoreductase activity
C1A40_RS05785	COG0714	Associated with various cellular activities
C1A40_RS05790	COG4221	oxidoreductase activity
C1A40_RS05800	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C1A40_RS05820	COG1309	transcriptional regulator
C1A40_RS05840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1A40_RS05845	COG0038	chloride channel
C1A40_RS05860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1A40_RS05875	COG1918	ferrous iron import across plasma membrane
C1A40_RS05875	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C1A40_RS05885	COG0792	nuclease activity
C1A40_RS05895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1A40_RS05900	COG3279	Response regulator of the LytR AlgR family
C1A40_RS05910	COG4251	negative regulation of phosphorylation
C1A40_RS05930	COG3328	transposase activity
C1A40_RS05935	COG1528	Iron-storage protein
C1A40_RS05940	COG2885	chlorophyll binding
C1A40_RS05950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1A40_RS05950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1A40_RS05955	COG1619	proteins homologs of microcin C7 resistance protein MccF
C1A40_RS05980	COG1418	mRNA catabolic process
C1A40_RS06020	COG1484	DNA-dependent DNA replication
C1A40_RS06030	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C1A40_RS06040	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
C1A40_RS06055	COG4771	TonB-dependent receptor
C1A40_RS06060	COG0702	epimerase
C1A40_RS06105	COG0758	DNA mediated transformation
C1A40_RS06105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1A40_RS06125	COG1607	acyl-coa hydrolase
C1A40_RS06130	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS06165	COG0756	dUTP diphosphatase activity
C1A40_RS06180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1A40_RS06185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1A40_RS06190	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1A40_RS06195	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1A40_RS06200	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1A40_RS06205	COG0356	it plays a direct role in the translocation of protons across the membrane
C1A40_RS06285	COG3385	transposase activity
C1A40_RS06295	COG3842	ATPase activity
C1A40_RS06310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1A40_RS06315	COG0439	Biotin carboxylase
C1A40_RS06320	COG0511	ligase activity, forming carbon-carbon bonds
C1A40_RS06325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1A40_RS06330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1A40_RS06340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1A40_RS06375	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1A40_RS06430	COG1396	sequence-specific DNA binding
C1A40_RS06435	COG4974	Belongs to the 'phage' integrase family
C1A40_RS06445	COG0346	lactoylglutathione lyase activity
C1A40_RS06450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1A40_RS06455	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1A40_RS06460	COG0470	DNA polymerase III
C1A40_RS06480	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS06495	COG0445	tRNA wobble uridine modification
C1A40_RS06500	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1A40_RS06510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1A40_RS06545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1A40_RS06550	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
C1A40_RS06555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1A40_RS06585	COG0702	epimerase
C1A40_RS06590	COG1629	transport
C1A40_RS06610	COG0557	exoribonuclease II activity
C1A40_RS06615	COG0698	ribose 5-phosphate isomerase
C1A40_RS06620	COG1230	cation diffusion facilitator family transporter
C1A40_RS06625	COG2153	protein acetylation
C1A40_RS06650	COG0793	Belongs to the peptidase S41A family
C1A40_RS06655	COG0594	ribonuclease P activity
C1A40_RS06665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1A40_RS06670	COG2022	thiamine diphosphate biosynthetic process
C1A40_RS06675	COG0352	thiamine-phosphate diphosphorylase activity
C1A40_RS06685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C1A40_RS06685	COG0351	phosphomethylpyrimidine kinase
C1A40_RS06685	COG0352	thiamine-phosphate diphosphorylase activity
C1A40_RS06700	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1A40_RS06720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1A40_RS06725	COG3263	regulation of cellular component size
C1A40_RS06760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1A40_RS06765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1A40_RS06770	COG0297	glycogen (starch) synthase activity
C1A40_RS06780	COG0481	GTPase activity
C1A40_RS06800	COG0126	phosphoglycerate kinase activity
C1A40_RS06805	COG1388	LysM domain
C1A40_RS06805	COG0791	NLP P60 protein
C1A40_RS06815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1A40_RS06855	COG1091	dTDP-4-dehydrorhamnose reductase activity
C1A40_RS06860	COG1086	Polysaccharide biosynthesis protein
C1A40_RS06865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1A40_RS06885	COG0667	Aldo Keto reductase
C1A40_RS06900	COG2089	acid synthase
C1A40_RS06985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1A40_RS06995	COG0859	PFAM glycosyl transferase family 9
C1A40_RS07005	COG1695	Transcriptional regulator
C1A40_RS07020	COG3385	transposase activity
C1A40_RS07030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1A40_RS07040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1A40_RS07050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1A40_RS07055	COG0408	coproporphyrinogen oxidase activity
C1A40_RS07060	COG3012	SEC-C Motif Domain Protein
C1A40_RS07065	COG0113	porphobilinogen synthase activity
C1A40_RS07080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A40_RS07090	COG1253	flavin adenine dinucleotide binding
C1A40_RS07095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1A40_RS07110	COG4172	Belongs to the ABC transporter superfamily
C1A40_RS07125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C1A40_RS07135	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1A40_RS07145	COG1774	PSP1 C-terminal conserved region
C1A40_RS07155	COG0826	peptidase U32
C1A40_RS07170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1A40_RS07200	COG1595	DNA-templated transcription, initiation
C1A40_RS07210	COG3385	transposase activity
C1A40_RS07235	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1A40_RS07245	COG1981	membrane
C1A40_RS07250	COG5000	phosphorelay sensor kinase activity
C1A40_RS07255	COG1024	Enoyl-CoA hydratase
C1A40_RS07265	COG1484	DNA-dependent DNA replication
C1A40_RS07270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1A40_RS07275	COG1970	mechanosensitive ion channel activity
C1A40_RS07280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1A40_RS07285	COG1435	thymidine kinase activity
C1A40_RS07295	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1A40_RS07305	COG1573	uracil-dna glycosylase
C1A40_RS07310	COG1476	TRANSCRIPTIONal
C1A40_RS07325	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1A40_RS07325	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C1A40_RS07335	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1A40_RS07375	COG0720	synthase
C1A40_RS07390	COG3385	transposase activity
C1A40_RS07410	COG4771	TonB-dependent receptor
C1A40_RS07465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1A40_RS07470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1A40_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS07485	COG0798	PFAM Bile acid sodium symporter
C1A40_RS07545	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1A40_RS07560	COG3047	cAMP biosynthetic process
C1A40_RS07560	COG2885	chlorophyll binding
C1A40_RS07570	COG1074	ATP-dependent DNA helicase activity
C1A40_RS07575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1A40_RS07635	COG0328	RNA-DNA hybrid ribonuclease activity
C1A40_RS07635	COG3341	Caulimovirus viroplasmin
C1A40_RS07645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1A40_RS07650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1A40_RS07655	COG0571	ribonuclease III activity
C1A40_RS07665	COG0469	pyruvate kinase activity
C1A40_RS07680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1A40_RS07685	COG2954	triphosphatase activity
C1A40_RS07705	COG1012	belongs to the aldehyde dehydrogenase family
C1A40_RS07725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1A40_RS07735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1A40_RS07740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1A40_RS07765	COG4771	TonB-dependent receptor
C1A40_RS07790	COG1999	signal sequence binding
C1A40_RS07795	COG0750	zinc metalloprotease
C1A40_RS07830	COG1484	DNA-dependent DNA replication
C1A40_RS07855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1A40_RS07865	COG1381	Involved in DNA repair and RecF pathway recombination
C1A40_RS07895	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1A40_RS07905	COG1629	transport
C1A40_RS07905	COG4206	TonB-dependent receptor
C1A40_RS07940	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1A40_RS07955	COG0084	hydrolase, TatD family'
C1A40_RS07960	COG0252	asparaginase activity
C1A40_RS07970	COG0811	peptide transport
C1A40_RS07980	COG0848	biopolymer transport protein
C1A40_RS08010	COG3385	transposase activity
C1A40_RS08015	COG0017	Asparaginyl-tRNA synthetase
C1A40_RS08030	COG0233	cytoplasmic translational termination
C1A40_RS08035	COG0528	UMP kinase activity
C1A40_RS08040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1A40_RS08045	COG0052	Belongs to the universal ribosomal protein uS2 family
C1A40_RS08050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1A40_RS08055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1A40_RS08060	COG0488	(ABC) transporter
C1A40_RS08065	COG1032	radical SAM domain protein
C1A40_RS08085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C1A40_RS08095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1A40_RS08100	COG0228	four-way junction DNA binding
C1A40_RS08105	COG2706	6-phosphogluconolactonase activity
C1A40_RS08130	COG0740	serine-type endopeptidase activity
C1A40_RS08185	COG1484	DNA-dependent DNA replication
C1A40_RS08195	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS08200	COG3328	transposase activity
C1A40_RS08205	COG4585	Histidine kinase
C1A40_RS08210	COG2197	response regulator
C1A40_RS08235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1A40_RS08240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1A40_RS08250	COG2315	Protein conserved in bacteria
C1A40_RS08260	COG2824	Alkylphosphonate utilization operon protein PhnA
C1A40_RS08285	COG3385	transposase activity
C1A40_RS08305	COG3328	transposase activity
C1A40_RS08330	COG1012	belongs to the aldehyde dehydrogenase family
C1A40_RS08335	COG4948	Mandelate Racemase Muconate Lactonizing
C1A40_RS08355	COG4771	TonB-dependent receptor
C1A40_RS08370	COG0800	Aldolase
C1A40_RS08380	COG2207	Transcriptional regulator
C1A40_RS08385	COG4771	TonB-dependent receptor
C1A40_RS08390	COG0702	epimerase
C1A40_RS08395	COG3119	arylsulfatase activity
C1A40_RS08410	COG2814	Major facilitator Superfamily
C1A40_RS08420	COG3119	arylsulfatase activity
C1A40_RS08440	COG1874	Beta-galactosidase
C1A40_RS08455	COG3119	arylsulfatase activity
C1A40_RS08460	COG0445	tRNA wobble uridine modification
C1A40_RS08470	COG1966	Carbon starvation protein
C1A40_RS08480	COG3119	arylsulfatase activity
C1A40_RS08485	COG3119	arylsulfatase activity
C1A40_RS08495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1A40_RS08500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1A40_RS08515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1A40_RS08520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1A40_RS08525	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C1A40_RS08545	COG1946	Acyl-CoA thioesterase
C1A40_RS08550	COG0584	glycerophosphoryl diester phosphodiesterase
C1A40_RS08555	COG2081	HI0933 family
C1A40_RS08600	COG1187	pseudouridine synthase activity
C1A40_RS08605	COG3385	transposase activity
C1A40_RS08610	COG0702	epimerase
C1A40_RS08615	COG1484	DNA-dependent DNA replication
C1A40_RS08635	COG0010	Belongs to the arginase family
C1A40_RS08640	COG1899	peptidyl-lysine modification to peptidyl-hypusine
C1A40_RS08645	COG3153	acetyltransferase
C1A40_RS08645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1A40_RS08680	COG1215	transferase activity, transferring glycosyl groups
C1A40_RS08685	COG0463	Glycosyl transferase, family 2
C1A40_RS08695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1A40_RS08725	COG2226	methyltransferase
C1A40_RS08730	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C1A40_RS08760	COG1054	Belongs to the UPF0176 family
C1A40_RS08775	COG1960	acyl-CoA dehydrogenase activity
C1A40_RS08780	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1A40_RS08790	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C1A40_RS08800	COG0848	biopolymer transport protein
C1A40_RS08810	COG0285	dihydrofolate synthase activity
C1A40_RS08840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1A40_RS08845	COG0719	Fe-S assembly protein
C1A40_RS08855	COG0396	ATPase activity
C1A40_RS08865	COG0719	Fe-S assembly protein
C1A40_RS08870	COG0316	Belongs to the HesB IscA family
C1A40_RS08875	COG1858	cytochrome C peroxidase
C1A40_RS08895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1A40_RS08910	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1A40_RS08920	COG0527	aspartate kinase activity
C1A40_RS08925	COG0006	proline dipeptidase activity
C1A40_RS08940	COG1053	succinate dehydrogenase
C1A40_RS08945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1A40_RS08960	COG0708	Exodeoxyribonuclease III
C1A40_RS08970	COG0667	Aldo Keto reductase
C1A40_RS08980	COG2733	membrane
C1A40_RS08985	COG1530	ribonuclease E activity
C1A40_RS08990	COG0776	regulation of translation
C1A40_RS09005	COG0629	single-stranded DNA binding
C1A40_RS09020	COG2217	Heavy metal translocating P-type atpase
C1A40_RS09025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1A40_RS09030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1A40_RS09075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1A40_RS09085	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C1A40_RS09110	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1A40_RS09130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1A40_RS09145	COG3852	Histidine kinase
C1A40_RS09155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1A40_RS09165	COG0519	Catalyzes the synthesis of GMP from XMP
C1A40_RS09185	COG1968	undecaprenyl-diphosphatase activity
C1A40_RS09190	COG1929	Belongs to the glycerate kinase type-1 family
C1A40_RS09200	COG2177	Part of the ABC transporter FtsEX involved in
C1A40_RS09205	COG0697	spore germination
C1A40_RS09210	COG0495	leucyl-tRNA aminoacylation
C1A40_RS09225	COG0686	Belongs to the AlaDH PNT family
C1A40_RS09230	COG2738	Putative neutral zinc metallopeptidase
C1A40_RS09255	COG0423	glycine-tRNA ligase activity
C1A40_RS09260	COG1522	sequence-specific DNA binding
C1A40_RS09270	COG2363	Small membrane protein
C1A40_RS09275	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1A40_RS09290	COG0463	Glycosyl transferase, family 2
C1A40_RS09295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1A40_RS09310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1A40_RS09335	COG3385	transposase activity
C1A40_RS09340	COG0745	RESPONSE REGULATOR receiver
C1A40_RS09345	COG5002	protein histidine kinase activity
C1A40_RS09350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1A40_RS09355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1A40_RS09365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1A40_RS09375	COG0489	protein tyrosine kinase activity
C1A40_RS09385	COG0633	Ferredoxin
C1A40_RS09405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1A40_RS09410	COG1252	NADH dehydrogenase
C1A40_RS09415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1A40_RS09420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1A40_RS09425	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C1A40_RS09430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1A40_RS09440	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C1A40_RS09445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1A40_RS09455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C1A40_RS09460	COG2086	electron transfer activity
C1A40_RS09470	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1A40_RS09470	COG0022	dehydrogenase e1 component
C1A40_RS09505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1A40_RS09510	COG0129	dihydroxy-acid dehydratase activity
C1A40_RS09515	COG0028	Belongs to the TPP enzyme family
C1A40_RS09525	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1A40_RS09530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1A40_RS09535	COG1012	belongs to the aldehyde dehydrogenase family
C1A40_RS09555	COG0137	argininosuccinate synthase activity
C1A40_RS09560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1A40_RS09565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1A40_RS09575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1A40_RS09585	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1A40_RS09595	COG0165	Argininosuccinate lyase
C1A40_RS09600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1A40_RS09605	COG0569	domain protein
C1A40_RS09610	COG3385	transposase activity
C1A40_RS09620	COG0473	3-isopropylmalate dehydrogenase activity
C1A40_RS09625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1A40_RS09645	COG0527	aspartate kinase activity
C1A40_RS09645	COG0460	homoserine dehydrogenase
C1A40_RS09655	COG0384	phenazine biosynthesis protein PhzF
C1A40_RS09665	COG1959	2 iron, 2 sulfur cluster binding
C1A40_RS09675	COG0175	sulfate reduction
C1A40_RS09680	COG0175	sulfate reduction
C1A40_RS09690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1A40_RS09705	COG0492	ferredoxin-NADP+ reductase activity
C1A40_RS09710	COG1045	serine acetyltransferase
C1A40_RS09720	COG0646	methionine synthase
C1A40_RS09720	COG1410	methionine synthase
C1A40_RS09735	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1A40_RS09755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1A40_RS09760	COG0857	belongs to the CobB CobQ family
C1A40_RS09760	COG0280	phosphate acetyltransferase
C1A40_RS09765	COG1131	(ABC) transporter
C1A40_RS09770	COG1605	Chorismate mutase
C1A40_RS09770	COG0077	Prephenate dehydratase
C1A40_RS09775	COG0436	Aminotransferase
C1A40_RS09780	COG0287	Prephenate dehydrogenase
C1A40_RS09785	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C1A40_RS09795	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS09800	COG1012	belongs to the aldehyde dehydrogenase family
C1A40_RS09805	COG1162	GTPase activity
C1A40_RS09810	COG1490	D-aminoacyl-tRNA deacylase activity
C1A40_RS09815	COG1988	membrane-bound metal-dependent
C1A40_RS09845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1A40_RS09850	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1A40_RS09855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1A40_RS09870	COG1305	Transglutaminase-like
C1A40_RS09880	COG2308	Evidence 4 Homologs of previously reported genes of
C1A40_RS09885	COG0358	DNA primase activity
C1A40_RS09890	COG2197	response regulator
C1A40_RS09895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C1A40_RS09915	COG0772	Belongs to the SEDS family
C1A40_RS09920	COG0768	penicillin binding
C1A40_RS09935	COG1077	Cell shape determining protein MreB Mrl
C1A40_RS09940	COG0138	bifunctional purine biosynthesis protein purh
C1A40_RS09980	COG3328	transposase activity
C1A40_RS09985	COG0459	protein refolding
C1A40_RS09990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1A40_RS10015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1A40_RS10025	COG1754	DNA topoisomerase type I activity
C1A40_RS10025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1A40_RS10035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1A40_RS10055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1A40_RS10065	COG0488	(ABC) transporter
C1A40_RS10130	COG1484	DNA-dependent DNA replication
C1A40_RS10140	COG1289	transmembrane transporter activity
C1A40_RS10155	COG1595	DNA-templated transcription, initiation
C1A40_RS10160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1A40_RS10165	COG0436	Aminotransferase
C1A40_RS10175	COG0525	valine-tRNA ligase activity
C1A40_RS10200	COG0688	phosphatidylethanolamine metabolic process
C1A40_RS10205	COG4589	Belongs to the CDS family
C1A40_RS10215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1A40_RS10220	COG0799	negative regulation of ribosome biogenesis
C1A40_RS10235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1A40_RS10245	COG2076	Multidrug Resistance protein
C1A40_RS10250	COG0659	secondary active sulfate transmembrane transporter activity
C1A40_RS10255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1A40_RS10260	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1A40_RS10265	COG2815	serine threonine protein kinase
C1A40_RS10265	COG0515	serine threonine protein kinase
C1A40_RS10270	COG0564	pseudouridine synthase activity
C1A40_RS10305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1A40_RS10310	COG1216	Glycosyl transferase, family 2
C1A40_RS10320	COG0463	Glycosyl transferase, family 2
C1A40_RS10325	COG0110	maltose O-acetyltransferase activity
C1A40_RS10330	COG0438	transferase activity, transferring glycosyl groups
C1A40_RS10370	COG0438	transferase activity, transferring glycosyl groups
C1A40_RS10380	COG3328	transposase activity
C1A40_RS10395	COG3645	SOS response
C1A40_RS10405	COG2827	Endonuclease containing a URI domain
C1A40_RS10410	COG0175	sulfate reduction
C1A40_RS10415	COG0529	Catalyzes the synthesis of activated sulfate
C1A40_RS10425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1A40_RS10430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1A40_RS10440	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C1A40_RS10480	COG0300	oxidoreductase activity
C1A40_RS10490	COG4452	Inner membrane protein CreD
C1A40_RS10495	COG3385	transposase activity
C1A40_RS10500	COG4452	Inner membrane protein CreD
C1A40_RS10525	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1A40_RS10530	COG1217	gtp-binding protein TYPA
C1A40_RS10555	COG2194	sulfuric ester hydrolase activity
C1A40_RS10565	COG0463	Glycosyl transferase, family 2
C1A40_RS10565	COG1216	Glycosyl transferase, family 2
C1A40_RS10575	COG2884	Cell division ATP-binding protein ftsE
C1A40_RS10600	COG3876	Protein conserved in bacteria
C1A40_RS10625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1A40_RS10630	COG1115	amino acid carrier protein
C1A40_RS10640	COG1960	acyl-CoA dehydrogenase activity
C1A40_RS10645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1A40_RS10650	COG4974	Belongs to the 'phage' integrase family
C1A40_RS10655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1A40_RS10680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1A40_RS10700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1A40_RS10705	COG0081	regulation of translation
C1A40_RS10710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1A40_RS10715	COG0222	ribosome binding
C1A40_RS10720	COG0085	RNA polymerase activity
C1A40_RS10725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1A40_RS10745	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1A40_RS10790	COG3385	transposase activity
C1A40_RS10855	COG3385	transposase activity
C1A40_RS10860	COG0385	Bile acid
C1A40_RS10880	COG3104	oligopeptide transport
C1A40_RS10885	COG3104	oligopeptide transport
C1A40_RS10890	COG4232	protein-disulfide reductase activity
C1A40_RS10895	COG0658	competence protein
C1A40_RS10895	COG2333	competence protein COMEC
C1A40_RS10900	COG0791	NLP P60 protein
C1A40_RS10905	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1A40_RS10915	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C1A40_RS10920	COG0793	Belongs to the peptidase S41A family
C1A40_RS10925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1A40_RS10930	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1A40_RS10940	COG2001	Belongs to the MraZ family
C1A40_RS10945	COG0275	rRNA processing
C1A40_RS10955	COG0768	penicillin binding
C1A40_RS10960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1A40_RS10965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1A40_RS10970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1A40_RS10975	COG0772	Belongs to the SEDS family
C1A40_RS10980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1A40_RS10985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1A40_RS11000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1A40_RS11005	COG1610	YqeY-like protein
C1A40_RS11015	COG4974	Belongs to the 'phage' integrase family
C1A40_RS11060	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1A40_RS11095	COG2217	Heavy metal translocating P-type atpase
C1A40_RS11115	COG2217	Heavy metal translocating P-type atpase
C1A40_RS11125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A40_RS11155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1A40_RS11160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1A40_RS11165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1A40_RS11180	COG1131	(ABC) transporter
C1A40_RS11205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1A40_RS11210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1A40_RS11220	COG0726	polysaccharide deacetylase
C1A40_RS11235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1A40_RS11250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1A40_RS11260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1A40_RS11265	COG1215	transferase activity, transferring glycosyl groups
C1A40_RS11280	COG1185	polyribonucleotide nucleotidyltransferase activity
C1A40_RS11285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1A40_RS11290	COG2198	Histidine kinase
C1A40_RS11290	COG0643	Histidine kinase
C1A40_RS11290	COG0784	Response regulator, receiver
C1A40_RS11295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1A40_RS11300	COG0191	fructose-bisphosphate aldolase activity
C1A40_RS11320	COG2226	methyltransferase
C1A40_RS11325	COG0569	domain protein
C1A40_RS11335	COG0436	Aminotransferase
C1A40_RS11340	COG3239	Fatty acid desaturase
C1A40_RS11345	COG0357	Ribosomal RNA small subunit methyltransferase G
C1A40_RS11365	COG1288	antiporter activity
C1A40_RS11390	COG1805	sodium ion transport
C1A40_RS11395	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1A40_RS11400	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1A40_RS11405	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1A40_RS11425	COG1477	protein flavinylation
C1A40_RS11435	COG3152	Membrane
C1A40_RS11440	COG0159	tryptophan synthase activity
C1A40_RS11445	COG0133	tryptophan synthase activity
C1A40_RS11450	COG0135	phosphoribosylanthranilate isomerase activity
C1A40_RS11455	COG0134	indole-3-glycerol-phosphate synthase activity
C1A40_RS11460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1A40_RS11470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1A40_RS11485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1A40_RS11490	COG1054	Belongs to the UPF0176 family
C1A40_RS11500	COG0657	acetylesterase activity
C1A40_RS11500	COG2755	lipolytic protein G-D-S-L family
C1A40_RS11505	COG3385	transposase activity
C1A40_RS11525	COG1187	pseudouridine synthase activity
C1A40_RS11530	COG3328	transposase activity
C1A40_RS11550	COG3275	phosphorelay sensor kinase activity
C1A40_RS11565	COG3279	Response regulator of the LytR AlgR family
C1A40_RS11570	COG1595	DNA-templated transcription, initiation
C1A40_RS11590	COG3385	transposase activity
C1A40_RS11620	COG0038	chloride channel
C1A40_RS11625	COG1012	belongs to the aldehyde dehydrogenase family
C1A40_RS11635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1A40_RS11650	COG1132	(ABC) transporter
C1A40_RS11685	COG3278	Belongs to the heme-copper respiratory oxidase family
C1A40_RS11695	COG2217	Heavy metal translocating P-type atpase
C1A40_RS11725	COG0561	phosphatase activity
C1A40_RS11730	COG0438	transferase activity, transferring glycosyl groups
C1A40_RS11740	COG1047	Peptidyl-prolyl cis-trans
C1A40_RS11750	COG0101	tRNA pseudouridine synthase activity
C1A40_RS11755	COG1132	(ABC) transporter
C1A40_RS11765	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS11780	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C1A40_RS11790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1A40_RS11805	COG0601	transmembrane transport
C1A40_RS11815	COG0149	triose-phosphate isomerase activity
C1A40_RS11825	COG2264	protein methyltransferase activity
C1A40_RS11835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1A40_RS11835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1A40_RS11875	COG4974	Belongs to the 'phage' integrase family
C1A40_RS11900	COG3385	transposase activity
C1A40_RS11910	COG0492	ferredoxin-NADP+ reductase activity
C1A40_RS11920	COG3328	transposase activity
C1A40_RS11970	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1A40_RS11975	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS11980	COG3385	transposase activity
C1A40_RS12035	COG3328	transposase activity
C1A40_RS12050	COG0778	Nitroreductase
C1A40_RS12070	COG0420	3'-5' exonuclease activity
C1A40_RS12075	COG0419	ATPase involved in DNA repair
C1A40_RS12085	COG3328	transposase activity
C1A40_RS12100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1A40_RS12105	COG0450	alkyl hydroperoxide reductase
C1A40_RS12110	COG1757	Na H antiporter
C1A40_RS12150	COG0542	response to heat
C1A40_RS12200	COG3005	denitrification pathway
C1A40_RS12205	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C1A40_RS12210	COG1333	cytochrome c biogenesis protein
C1A40_RS12210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1A40_RS12270	COG1104	cysteine desulfurase activity
C1A40_RS12300	COG1418	mRNA catabolic process
C1A40_RS12330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1A40_RS12335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1A40_RS12340	COG1252	NADH dehydrogenase
C1A40_RS12360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1A40_RS12365	COG1522	sequence-specific DNA binding
C1A40_RS12370	COG0542	response to heat
C1A40_RS12375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1A40_RS12385	COG0791	NLP P60 protein
C1A40_RS12390	COG0183	Belongs to the thiolase family
C1A40_RS12415	COG3250	beta-galactosidase activity
C1A40_RS12420	COG1063	alcohol dehydrogenase
C1A40_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS12430	COG3119	arylsulfatase activity
C1A40_RS12435	COG1012	belongs to the aldehyde dehydrogenase family
C1A40_RS12440	COG3119	arylsulfatase activity
C1A40_RS12445	COG1472	Belongs to the glycosyl hydrolase 3 family
C1A40_RS12450	COG4948	Mandelate Racemase Muconate Lactonizing
C1A40_RS12455	COG2017	converts alpha-aldose to the beta-anomer
C1A40_RS12470	COG4771	TonB-dependent receptor
C1A40_RS12475	COG0702	epimerase
C1A40_RS12500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1A40_RS12510	COG0191	fructose-bisphosphate aldolase activity
C1A40_RS12515	COG1063	alcohol dehydrogenase
C1A40_RS12530	COG1012	belongs to the aldehyde dehydrogenase family
C1A40_RS12535	COG1024	Enoyl-CoA hydratase
C1A40_RS12540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1A40_RS12585	COG0633	Ferredoxin
C1A40_RS12590	COG2124	cytochrome p450
C1A40_RS12595	COG4977	sequence-specific DNA binding
C1A40_RS12605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C1A40_RS12610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1A40_RS12645	COG0300	oxidoreductase activity
C1A40_RS12660	COG1396	sequence-specific DNA binding
C1A40_RS12675	COG3385	transposase activity
C1A40_RS12725	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS12730	COG3328	transposase activity
C1A40_RS12750	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1A40_RS12795	COG2188	Transcriptional regulator
C1A40_RS12800	COG0745	RESPONSE REGULATOR receiver
C1A40_RS12800	COG3292	Two component regulator propeller
C1A40_RS12800	COG2205	protein histidine kinase activity
C1A40_RS12805	COG4771	TonB-dependent receptor
C1A40_RS12810	COG0702	epimerase
C1A40_RS12820	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C1A40_RS12825	COG3408	Glycogen debranching enzyme
C1A40_RS12825	COG3119	arylsulfatase activity
C1A40_RS12830	COG0673	inositol 2-dehydrogenase activity
C1A40_RS12835	COG3507	Belongs to the glycosyl hydrolase 43 family
C1A40_RS12840	COG1472	Belongs to the glycosyl hydrolase 3 family
C1A40_RS12845	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C1A40_RS12850	COG3119	arylsulfatase activity
C1A40_RS12855	COG3664	PFAM glycoside hydrolase family 39
C1A40_RS12860	COG3250	beta-galactosidase activity
C1A40_RS12865	COG3408	Glycogen debranching enzyme
C1A40_RS12870	COG3940	Belongs to the glycosyl hydrolase 43 family
C1A40_RS12900	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS12910	COG3940	Belongs to the glycosyl hydrolase 43 family
C1A40_RS12955	COG3408	Glycogen debranching enzyme
C1A40_RS12965	COG3507	Belongs to the glycosyl hydrolase 43 family
C1A40_RS12970	COG3119	arylsulfatase activity
C1A40_RS12990	COG1629	transport
C1A40_RS12995	COG0702	epimerase
C1A40_RS13000	COG1472	Belongs to the glycosyl hydrolase 3 family
C1A40_RS13005	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
C1A40_RS13020	COG3254	rhamnose metabolic process
C1A40_RS13030	COG3408	Glycogen debranching enzyme
C1A40_RS13035	COG3408	Glycogen debranching enzyme
C1A40_RS13040	COG3119	arylsulfatase activity
C1A40_RS13045	COG3119	arylsulfatase activity
C1A40_RS13050	COG3250	beta-galactosidase activity
C1A40_RS13055	COG3250	beta-galactosidase activity
C1A40_RS13065	COG3940	Belongs to the glycosyl hydrolase 43 family
C1A40_RS13085	COG3119	arylsulfatase activity
C1A40_RS13090	COG3119	arylsulfatase activity
C1A40_RS13095	COG3119	arylsulfatase activity
C1A40_RS13100	COG3119	arylsulfatase activity
C1A40_RS13110	COG2706	6-phosphogluconolactonase activity
C1A40_RS13120	COG3250	beta-galactosidase activity
C1A40_RS13125	COG4677	pectinesterase activity
C1A40_RS13130	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS13135	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C1A40_RS13140	COG3385	transposase activity
C1A40_RS13150	COG3292	Two component regulator propeller
C1A40_RS13150	COG2205	protein histidine kinase activity
C1A40_RS13150	COG0745	RESPONSE REGULATOR receiver
C1A40_RS13155	COG4771	TonB-dependent receptor
C1A40_RS13160	COG0702	epimerase
C1A40_RS13165	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C1A40_RS13175	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS13185	COG1904	glucuronate isomerase
C1A40_RS13190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1A40_RS13205	COG3347	Dehydrogenase
C1A40_RS13205	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS13210	COG4952	isomerase
C1A40_RS13215	COG1070	Carbohydrate kinase
C1A40_RS13220	COG0235	Class ii aldolase
C1A40_RS13225	COG1304	FMN binding
C1A40_RS13230	COG1012	belongs to the aldehyde dehydrogenase family
C1A40_RS13275	COG1678	Uncharacterized ACR, COG1678
C1A40_RS13280	COG0776	regulation of translation
C1A40_RS13285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1A40_RS13290	COG0514	ATP-dependent DNA helicase (RecQ)
C1A40_RS13310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1A40_RS13320	COG3385	transposase activity
C1A40_RS13335	COG4585	Histidine kinase
C1A40_RS13340	COG0564	pseudouridine synthase activity
C1A40_RS13345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1A40_RS13365	COG0673	inositol 2-dehydrogenase activity
C1A40_RS13395	COG0598	Magnesium transport protein CorA
C1A40_RS13410	COG0424	maF-like protein
C1A40_RS13460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1A40_RS13460	COG1333	cytochrome c biogenesis protein
C1A40_RS13475	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS13490	COG1970	mechanosensitive ion channel activity
C1A40_RS13495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1A40_RS13500	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C1A40_RS13505	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C1A40_RS13515	COG0789	Transcriptional regulator
C1A40_RS13520	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C1A40_RS13555	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C1A40_RS13565	COG0415	Belongs to the DNA photolyase family
C1A40_RS13570	COG2234	aminopeptidase activity
C1A40_RS13575	COG0490	domain, Protein
C1A40_RS13575	COG2985	domain, Protein
C1A40_RS13580	COG1346	cytolysis
C1A40_RS13590	COG0592	DNA-directed DNA polymerase activity
C1A40_RS13615	COG1702	phosphate starvation-inducible protein PhoH
C1A40_RS13640	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1A40_RS13660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1A40_RS13665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1A40_RS13680	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1A40_RS13685	COG1132	(ABC) transporter
C1A40_RS13695	COG2814	Major facilitator Superfamily
C1A40_RS13715	COG0513	Belongs to the DEAD box helicase family
C1A40_RS13725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1A40_RS13730	COG0439	Biotin carboxylase
C1A40_RS13760	COG1363	Peptidase, m42
C1A40_RS13770	COG1272	protein, Hemolysin III
C1A40_RS13885	COG2369	cell adhesion
C1A40_RS13940	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1A40_RS14060	COG2226	methyltransferase
C1A40_RS14065	COG0116	Belongs to the methyltransferase superfamily
C1A40_RS14090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1A40_RS14095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1A40_RS14120	COG3385	transposase activity
C1A40_RS14130	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS14135	COG1484	DNA-dependent DNA replication
C1A40_RS14145	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS14175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1A40_RS14180	COG0587	DNA-directed DNA polymerase activity
C1A40_RS14200	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS14215	COG3328	transposase activity
C1A40_RS14240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1A40_RS14245	COG0484	heat shock protein binding
C1A40_RS14265	COG3328	transposase activity
C1A40_RS14270	COG2274	protein secretion by the type I secretion system
C1A40_RS14300	COG1484	DNA-dependent DNA replication
C1A40_RS14315	COG3177	Filamentation induced by cAMP protein fic
C1A40_RS14330	COG0300	oxidoreductase activity
C1A40_RS14395	COG3279	Response regulator of the LytR AlgR family
C1A40_RS14400	COG3275	phosphorelay sensor kinase activity
C1A40_RS14405	COG4771	TonB-dependent receptor
C1A40_RS14415	COG0363	glucosamine-6-phosphate deaminase activity
C1A40_RS14455	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS14475	COG3153	acetyltransferase
C1A40_RS14490	COG0628	permease
C1A40_RS14510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1A40_RS14515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1A40_RS14525	COG0205	6-phosphofructokinase activity
C1A40_RS14540	COG1119	ATPase activity
C1A40_RS14550	COG2205	protein histidine kinase activity
C1A40_RS14550	COG2198	Histidine kinase
C1A40_RS14550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A40_RS14550	COG0784	Response regulator, receiver
C1A40_RS14560	COG2198	Histidine kinase
C1A40_RS14560	COG5002	protein histidine kinase activity
C1A40_RS14560	COG0784	Response regulator, receiver
C1A40_RS14565	COG0251	oxidation-reduction process
C1A40_RS14575	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1A40_RS14580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1A40_RS14585	COG2181	nitrate reductase activity
C1A40_RS14585	COG0247	lactate metabolic process
C1A40_RS14590	COG2181	nitrate reductase activity
C1A40_RS14590	COG0247	lactate metabolic process
C1A40_RS14605	COG0438	transferase activity, transferring glycosyl groups
C1A40_RS14620	COG1484	DNA-dependent DNA replication
C1A40_RS14635	COG0277	FAD linked oxidase domain protein
C1A40_RS14635	COG0247	lactate metabolic process
C1A40_RS14645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1A40_RS14650	COG1301	dicarboxylic acid transport
C1A40_RS14660	COG2897	thiosulfate sulfurtransferase activity
C1A40_RS14665	COG3011	Protein conserved in bacteria
C1A40_RS14670	COG1193	negative regulation of DNA recombination
C1A40_RS14680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1A40_RS14690	COG0071	Belongs to the small heat shock protein (HSP20) family
C1A40_RS14700	COG0308	aminopeptidase N
C1A40_RS14715	COG0069	glutamate synthase activity
C1A40_RS14730	COG0009	L-threonylcarbamoyladenylate synthase
C1A40_RS14755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1A40_RS14770	COG1575	Belongs to the MenA family. Type 1 subfamily
C1A40_RS14775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1A40_RS14780	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1A40_RS14785	COG4948	Mandelate Racemase Muconate Lactonizing
C1A40_RS14790	COG1266	CAAX protease self-immunity
C1A40_RS14800	COG0616	signal peptide processing
C1A40_RS14810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1A40_RS14820	COG1846	Transcriptional regulator
C1A40_RS14825	COG1741	Belongs to the pirin family
C1A40_RS14830	COG2814	Major facilitator Superfamily
C1A40_RS14835	COG2271	Major facilitator Superfamily
C1A40_RS14845	COG0488	(ABC) transporter
C1A40_RS14850	COG0494	nUDIX hydrolase
C1A40_RS14855	COG0010	Belongs to the arginase family
C1A40_RS14885	COG1393	Belongs to the ArsC family
C1A40_RS14895	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1A40_RS14910	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1A40_RS14915	COG1770	oligopeptidase
C1A40_RS14925	COG0156	8-amino-7-oxononanoate synthase activity
C1A40_RS14980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1A40_RS14990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1A40_RS14995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1A40_RS15005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1A40_RS15005	COG0321	lipoyl(octanoyl) transferase activity
C1A40_RS15030	COG1522	sequence-specific DNA binding
C1A40_RS15045	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1A40_RS15065	COG3328	transposase activity
C1A40_RS15085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1A40_RS15110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1A40_RS15115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1A40_RS15125	COG1454	alcohol dehydrogenase
C1A40_RS15145	COG0673	inositol 2-dehydrogenase activity
C1A40_RS15150	COG0217	transcriptional regulatory protein
C1A40_RS15155	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1A40_RS15165	COG2066	Belongs to the glutaminase family
C1A40_RS15170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1A40_RS15190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1A40_RS15195	COG0083	homoserine kinase activity
C1A40_RS15200	COG0460	homoserine dehydrogenase
C1A40_RS15200	COG0527	aspartate kinase activity
C1A40_RS15205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1A40_RS15210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1A40_RS15225	COG0813	purine-nucleoside phosphorylase activity
C1A40_RS15245	COG0022	dehydrogenase e1 component
C1A40_RS15255	COG0667	Aldo Keto reductase
C1A40_RS15260	COG0668	transmembrane transport
C1A40_RS15265	COG2814	Major facilitator Superfamily
C1A40_RS15280	COG2274	protein secretion by the type I secretion system
C1A40_RS15305	COG3800	Transcriptional regulator
C1A40_RS15305	COG1396	sequence-specific DNA binding
C1A40_RS15325	COG1733	regulation of RNA biosynthetic process
C1A40_RS15355	COG0300	oxidoreductase activity
C1A40_RS15360	COG0471	metal ion transport
C1A40_RS15370	COG1309	transcriptional regulator
C1A40_RS15385	COG2130	NADP-dependent
C1A40_RS15390	COG1979	alcohol dehydrogenase
C1A40_RS15405	COG0513	Belongs to the DEAD box helicase family
C1A40_RS15450	COG2308	Evidence 4 Homologs of previously reported genes of
C1A40_RS15465	COG0697	spore germination
C1A40_RS15470	COG1278	Cold shock
C1A40_RS15480	COG3385	transposase activity
C1A40_RS15485	COG3385	transposase activity
C1A40_RS15495	COG3385	transposase activity
C1A40_RS15510	COG3385	transposase activity
C1A40_RS15535	COG0473	3-isopropylmalate dehydrogenase activity
C1A40_RS15545	COG0066	3-isopropylmalate dehydratase activity
C1A40_RS15550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1A40_RS15555	COG1607	acyl-coa hydrolase
C1A40_RS15580	COG0101	tRNA pseudouridine synthase activity
C1A40_RS15585	COG0140	phosphoribosyl-ATP diphosphatase activity
C1A40_RS15585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1A40_RS15590	COG0107	imidazoleglycerol-phosphate synthase activity
C1A40_RS15595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1A40_RS15600	COG2827	Endonuclease containing a URI domain
C1A40_RS15610	COG0131	Imidazoleglycerol-phosphate dehydratase
C1A40_RS15620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1A40_RS15625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1A40_RS15630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1A40_RS15645	COG1028	Short-chain dehydrogenase reductase Sdr
C1A40_RS15650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1A40_RS15655	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1A40_RS15660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1A40_RS15665	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1A40_RS15670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1A40_RS15670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1A40_RS15675	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1A40_RS15680	COG1078	dGTPase activity
C1A40_RS15685	COG2204	response regulator
C1A40_RS15690	COG0802	atpase or kinase
C1A40_RS15695	COG3385	transposase activity
C1A40_RS15700	COG0686	Belongs to the AlaDH PNT family
C1A40_RS15710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1A40_RS15715	COG1086	Polysaccharide biosynthesis protein
C1A40_RS15720	COG3385	transposase activity
C1A40_RS15725	COG1086	Polysaccharide biosynthesis protein
C1A40_RS15730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1A40_RS15740	COG0259	pyridoxamine-phosphate oxidase activity
C1A40_RS15750	COG1234	tRNA 3'-trailer cleavage
C1A40_RS15760	COG0540	Belongs to the ATCase OTCase family
C1A40_RS15765	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C1A40_RS15780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1A40_RS15790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1A40_RS15805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1A40_RS15815	COG0405	Gamma-glutamyltransferase
C1A40_RS15835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1A40_RS15840	COG1611	Belongs to the LOG family
C1A40_RS15850	COG0022	dehydrogenase e1 component
C1A40_RS15880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1A40_RS15885	COG2217	Heavy metal translocating P-type atpase
C1A40_RS15895	COG4974	Belongs to the 'phage' integrase family
C1A40_RS15925	COG4680	protein conserved in bacteria
C1A40_RS15955	COG1484	DNA-dependent DNA replication
C1A40_RS15995	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS16015	COG3657	addiction module killer protein
C1A40_RS16020	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1A40_RS16025	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS16035	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS16065	COG4680	protein conserved in bacteria
C1A40_RS16095	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS16100	COG3250	beta-galactosidase activity
C1A40_RS16105	COG1082	Xylose isomerase domain protein TIM barrel
C1A40_RS16110	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1A40_RS16120	COG2160	L-arabinose isomerase activity
C1A40_RS16130	COG1069	ribulokinase activity
C1A40_RS16135	COG3940	Belongs to the glycosyl hydrolase 43 family
C1A40_RS16140	COG2211	Major facilitator Superfamily
C1A40_RS16150	COG3507	Belongs to the glycosyl hydrolase 43 family
C1A40_RS16155	COG3507	Belongs to the glycosyl hydrolase 43 family
C1A40_RS16160	COG3507	Belongs to the glycosyl hydrolase 43 family
C1A40_RS16170	COG0702	epimerase
C1A40_RS16175	COG1629	transport
C1A40_RS16180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1A40_RS16185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1A40_RS16200	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS16260	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS16285	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS16335	COG3328	transposase activity
C1A40_RS16340	COG1090	epimerase
C1A40_RS16350	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C1A40_RS16350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1A40_RS16355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1A40_RS16385	COG0492	ferredoxin-NADP+ reductase activity
C1A40_RS16395	COG1522	sequence-specific DNA binding
C1A40_RS16405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1A40_RS16405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1A40_RS16405	COG1703	isobutyryl-CoA mutase activity
C1A40_RS16410	COG0788	formyltetrahydrofolate deformylase activity
C1A40_RS16430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1A40_RS16435	COG0284	orotidine-5'-phosphate decarboxylase activity
C1A40_RS16440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1A40_RS16455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1A40_RS16465	COG0174	glutamine synthetase
C1A40_RS16480	COG3956	TIGRFAM MazG family protein
C1A40_RS16495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1A40_RS16520	COG0714	Associated with various cellular activities
C1A40_RS16525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1A40_RS16535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1A40_RS16545	COG3530	Putative quorum-sensing-regulated virulence factor
C1A40_RS16550	COG1376	ErfK ybiS ycfS ynhG family protein
C1A40_RS16555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1A40_RS16555	COG0519	Catalyzes the synthesis of GMP from XMP
C1A40_RS16560	COG0076	glutamate decarboxylase activity
C1A40_RS16565	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C1A40_RS16575	COG1858	cytochrome C peroxidase
C1A40_RS16610	COG0243	molybdopterin cofactor binding
C1A40_RS16660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1A40_RS16680	COG2814	Major facilitator Superfamily
C1A40_RS16680	COG0477	Major facilitator Superfamily
C1A40_RS16685	COG2115	Belongs to the xylose isomerase family
C1A40_RS16690	COG1070	Carbohydrate kinase
C1A40_RS16695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1A40_RS16700	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C1A40_RS16705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1A40_RS16705	COG2080	2 iron, 2 sulfur cluster binding
C1A40_RS16720	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C1A40_RS16725	COG0037	tRNA processing
C1A40_RS16730	COG0512	Glutamine amidotransferase of anthranilate synthase
C1A40_RS16730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1A40_RS16740	COG0513	Belongs to the DEAD box helicase family
C1A40_RS16760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1A40_RS16765	COG3360	Dodecin
C1A40_RS16770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1A40_RS16780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1A40_RS16785	COG0673	inositol 2-dehydrogenase activity
C1A40_RS16790	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1A40_RS16800	COG2176	DNA-directed DNA polymerase activity
C1A40_RS16805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1A40_RS16835	COG3328	transposase activity
C1A40_RS16840	COG1484	DNA-dependent DNA replication
C1A40_RS16850	COG3385	transposase activity
C1A40_RS16860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1A40_RS16865	COG2996	Protein conserved in bacteria
C1A40_RS16870	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1A40_RS16880	COG2050	protein possibly involved in aromatic compounds catabolism
C1A40_RS16890	COG2070	2-Nitropropane dioxygenase
C1A40_RS16900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1A40_RS16920	COG0443	Heat shock 70 kDa protein
C1A40_RS16965	COG1696	Membrane protein involved in D-alanine export
C1A40_RS16975	COG3385	transposase activity
C1A40_RS17025	COG2755	lipolytic protein G-D-S-L family
C1A40_RS17035	COG3458	cephalosporin-C deacetylase activity
C1A40_RS17045	COG2755	lipolytic protein G-D-S-L family
C1A40_RS17050	COG1472	Belongs to the glycosyl hydrolase 3 family
C1A40_RS17075	COG4771	TonB-dependent receptor
C1A40_RS17080	COG3292	Two component regulator propeller
C1A40_RS17080	COG2205	protein histidine kinase activity
C1A40_RS17080	COG0745	RESPONSE REGULATOR receiver
C1A40_RS17110	COG1271	oxidase subunit
C1A40_RS17125	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C1A40_RS17130	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C1A40_RS17140	COG1674	ftsk spoiiie
C1A40_RS17155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1A40_RS17155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1A40_RS17160	COG3385	transposase activity
C1A40_RS17165	COG3385	transposase activity
C1A40_RS17175	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS17195	COG2826	transposase and inactivated derivatives, IS30 family
C1A40_RS17200	COG3385	transposase activity
C1A40_RS17205	COG3328	transposase activity
C1A40_RS17275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1A40_RS17280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1A40_RS17285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1A40_RS17290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1A40_RS17310	COG3328	transposase activity
C1A40_RS17325	COG0305	Participates in initiation and elongation during chromosome replication
C1A40_RS17330	COG0825	malonyl-CoA metabolic process
C1A40_RS17340	COG0343	queuine tRNA-ribosyltransferase activity
C1A40_RS17350	COG0045	succinate-CoA ligase (ADP-forming) activity
C1A40_RS17365	COG2326	polyphosphate kinase activity
C1A40_RS17375	COG2204	response regulator
C1A40_RS17380	COG3264	Mechanosensitive ion channel
C1A40_RS17380	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1A40_RS17385	COG1668	transmembrane transport
C1A40_RS17390	COG4152	abc transporter atp-binding protein
C1A40_RS17425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1A40_RS17440	COG1595	DNA-templated transcription, initiation
C1A40_RS17450	COG1703	isobutyryl-CoA mutase activity
C1A40_RS17455	COG0671	phosphoesterase, PA-phosphatase related
C1A40_RS17465	COG0534	Mate efflux family protein
C1A40_RS17480	COG0482	sulfurtransferase activity
C1A40_RS17490	COG0706	membrane insertase activity
C1A40_RS17495	COG0504	CTP synthase activity
C1A40_RS17500	COG4106	trans-aconitate 2-methyltransferase activity
C1A40_RS17510	COG0302	gtp cyclohydrolase
C1A40_RS17515	COG1136	(ABC) transporter
C1A40_RS17545	COG1215	transferase activity, transferring glycosyl groups
C1A40_RS17555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1A40_RS17575	COG1482	cell wall glycoprotein biosynthetic process
C1A40_RS17595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1A40_RS17610	COG0124	histidyl-tRNA synthetase
C1A40_RS17620	COG0359	binds to the 23S rRNA
C1A40_RS17625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1A40_RS17630	COG0360	Binds together with S18 to 16S ribosomal RNA
C1A40_RS17635	COG3279	Response regulator of the LytR AlgR family
C1A40_RS17640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1A40_RS17645	COG1295	ribonuclease BN
C1A40_RS17655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1A40_RS17675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1A40_RS17690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1A40_RS17700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1A40_RS17720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1A40_RS17740	COG1484	DNA-dependent DNA replication
C1A40_RS17745	COG3328	transposase activity
C1A40_RS17750	COG0488	(ABC) transporter
C1A40_RS17770	COG2161	toxin-antitoxin pair type II binding
C1A40_RS17775	COG4115	mRNA cleavage
C1A40_RS17780	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C1A40_RS17785	COG2321	neutral zinc metallopeptidase
C1A40_RS17795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1A40_RS17870	COG1428	Deoxynucleoside kinase
C1A40_RS17875	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C1A40_RS17880	COG3385	transposase activity
C1A40_RS17885	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1A40_RS17890	COG3385	transposase activity
C1A40_RS17895	COG0336	Belongs to the RNA methyltransferase TrmD family
C1A40_RS17900	COG0335	large ribosomal subunit rRNA binding
C1A40_RS17910	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C1A40_RS17925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1A40_RS17940	COG0237	dephospho-CoA kinase activity
C1A40_RS17955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1A40_RS17960	COG0497	DNA recombination
C1A40_RS17985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1A40_RS18000	COG0737	Belongs to the 5'-nucleotidase family
C1A40_RS18010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1A40_RS18015	COG2890	protein-(glutamine-N5) methyltransferase activity
C1A40_RS18020	COG0456	acetyltransferase
C1A40_RS18030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1A40_RS18030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1A40_RS18040	COG1739	Uncharacterized protein family UPF0029
C1A40_RS18045	COG0824	Thioesterase