locus-tag	class	description
BFO_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BFO_RS00025	COG0335	large ribosomal subunit rRNA binding
BFO_RS00045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFO_RS00060	COG3590	peptidase
BFO_RS00075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFO_RS00080	COG1120	ATPase activity
BFO_RS00095	COG0543	2 iron, 2 sulfur cluster binding
BFO_RS00100	COG0167	dihydroorotate dehydrogenase activity
BFO_RS00120	COG1285	pathogenesis
BFO_RS00130	COG0101	tRNA pseudouridine synthase activity
BFO_RS00140	COG1797	cobyrinic acid a,c-diamide synthase activity
BFO_RS00145	COG5297	Belongs to the glycosyl hydrolase family 6
BFO_RS00145	COG3250	beta-galactosidase activity
BFO_RS00155	COG1629	transport
BFO_RS00155	COG4206	TonB-dependent receptor
BFO_RS00170	COG1629	transport
BFO_RS00185	COG1215	transferase activity, transferring glycosyl groups
BFO_RS00195	COG2385	sporulation resulting in formation of a cellular spore
BFO_RS00195	COG2247	cell wall binding repeat
BFO_RS00200	COG2211	Major facilitator Superfamily
BFO_RS00205	COG3876	Protein conserved in bacteria
BFO_RS00220	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BFO_RS00225	COG0561	phosphatase activity
BFO_RS00300	COG0641	radical SAM
BFO_RS00360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BFO_RS00390	COG2274	protein secretion by the type I secretion system
BFO_RS00410	COG0438	transferase activity, transferring glycosyl groups
BFO_RS00560	COG1187	pseudouridine synthase activity
BFO_RS00585	COG1132	(ABC) transporter
BFO_RS00590	COG1132	(ABC) transporter
BFO_RS00600	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BFO_RS00615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BFO_RS00635	COG2223	nitrite transmembrane transporter activity
BFO_RS00640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BFO_RS00650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BFO_RS00655	COG0543	2 iron, 2 sulfur cluster binding
BFO_RS00660	COG0493	'glutamate synthase
BFO_RS00665	COG3015	lipoprotein NlpE involved in copper resistance
BFO_RS00670	COG1051	belongs to the nudix hydrolase family
BFO_RS00675	COG1970	mechanosensitive ion channel activity
BFO_RS00680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BFO_RS00690	COG0745	RESPONSE REGULATOR receiver
BFO_RS00690	COG2972	Histidine kinase
BFO_RS00720	COG4591	ABC-type transport system involved in lipoprotein release permease component
BFO_RS00720	COG1136	(ABC) transporter
BFO_RS00795	COG0438	transferase activity, transferring glycosyl groups
BFO_RS00805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFO_RS00820	COG0237	dephospho-CoA kinase activity
BFO_RS00830	COG1862	Preprotein translocase
BFO_RS00835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BFO_RS00840	COG0252	asparaginase activity
BFO_RS00860	COG1629	transport
BFO_RS00880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BFO_RS00890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFO_RS00900	COG1011	Hydrolase
BFO_RS00905	COG1595	DNA-templated transcription, initiation
BFO_RS00965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BFO_RS00975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFO_RS00980	COG0235	Class ii aldolase
BFO_RS00990	COG4806	L-rhamnose isomerase
BFO_RS00995	COG1070	Carbohydrate kinase
BFO_RS01010	COG0442	prolyl-tRNA aminoacylation
BFO_RS01015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BFO_RS01025	COG1704	LemA family
BFO_RS01030	COG0501	Belongs to the peptidase M48B family
BFO_RS01035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BFO_RS01040	COG0126	phosphoglycerate kinase activity
BFO_RS01045	COG0534	Mate efflux family protein
BFO_RS01085	COG0484	heat shock protein binding
BFO_RS01090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BFO_RS01095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS01100	COG1193	negative regulation of DNA recombination
BFO_RS01115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BFO_RS01125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFO_RS01155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BFO_RS01165	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BFO_RS01180	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BFO_RS01185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BFO_RS01195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BFO_RS01215	COG2264	protein methyltransferase activity
BFO_RS01235	COG1373	ATPase (AAA superfamily
BFO_RS01240	COG4804	nuclease activity
BFO_RS01300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BFO_RS01305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BFO_RS01310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BFO_RS01340	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
BFO_RS01345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BFO_RS01360	COG4771	TonB-dependent receptor
BFO_RS01365	COG0702	epimerase
BFO_RS01370	COG3250	beta-galactosidase activity
BFO_RS01380	COG2431	L-lysine efflux transmembrane transporter activity
BFO_RS01385	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BFO_RS01390	COG3339	Conserved Protein
BFO_RS01400	COG0738	Major facilitator superfamily
BFO_RS01405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BFO_RS01405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BFO_RS01410	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BFO_RS01415	COG2885	chlorophyll binding
BFO_RS01420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BFO_RS01420	COG1333	cytochrome c biogenesis protein
BFO_RS01425	COG0823	Involved in the tonB-independent uptake of proteins
BFO_RS01425	COG1506	peptidase
BFO_RS01435	COG3537	Alpha-1,2-mannosidase
BFO_RS01445	COG0534	Mate efflux family protein
BFO_RS01450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BFO_RS01455	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BFO_RS01460	COG0297	glycogen (starch) synthase activity
BFO_RS01520	COG1045	serine acetyltransferase
BFO_RS01565	COG0681	Belongs to the peptidase S26 family
BFO_RS01675	COG0681	Belongs to the peptidase S26 family
BFO_RS01685	COG1216	Glycosyl transferase, family 2
BFO_RS01685	COG0463	Glycosyl transferase, family 2
BFO_RS01690	COG3591	Belongs to the peptidase S1B family
BFO_RS01705	COG2255	four-way junction helicase activity
BFO_RS01770	COG2860	membrane
BFO_RS01775	COG4771	TonB-dependent receptor
BFO_RS01785	COG1610	YqeY-like protein
BFO_RS01790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BFO_RS01805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BFO_RS01815	COG0772	Belongs to the SEDS family
BFO_RS01820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BFO_RS01825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BFO_RS01830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BFO_RS01835	COG0768	penicillin binding
BFO_RS01845	COG0275	rRNA processing
BFO_RS01860	COG0698	ribose 5-phosphate isomerase
BFO_RS01865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BFO_RS01870	COG0427	acetyl-CoA hydrolase
BFO_RS01875	COG0546	phosphoglycolate phosphatase activity
BFO_RS01920	COG1595	DNA-templated transcription, initiation
BFO_RS01930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BFO_RS01935	COG0658	competence protein
BFO_RS01935	COG2333	competence protein COMEC
BFO_RS01940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFO_RS01945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS01970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BFO_RS01970	COG0519	Catalyzes the synthesis of GMP from XMP
BFO_RS01980	COG4886	Leucine-rich repeat (LRR) protein
BFO_RS01985	COG0501	Belongs to the peptidase M48B family
BFO_RS01990	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BFO_RS01995	COG0534	Mate efflux family protein
BFO_RS02000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFO_RS02020	COG0312	modulator of DNA gyrase
BFO_RS02030	COG3250	beta-galactosidase activity
BFO_RS02035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFO_RS02040	COG5183	chlorophyll binding
BFO_RS02040	COG2133	pyrroloquinoline quinone binding
BFO_RS02060	COG0363	glucosamine-6-phosphate deaminase activity
BFO_RS02065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BFO_RS02080	COG0577	efflux transmembrane transporter activity
BFO_RS02080	COG1136	(ABC) transporter
BFO_RS02085	COG1136	(ABC) transporter
BFO_RS02085	COG0577	efflux transmembrane transporter activity
BFO_RS02090	COG1136	(ABC) transporter
BFO_RS02095	COG0366	Alpha amylase catalytic
BFO_RS02105	COG4953	penicillin-binding protein 1C
BFO_RS02110	COG2373	Large extracellular alpha-helical protein
BFO_RS02115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BFO_RS02125	COG0165	Argininosuccinate lyase
BFO_RS02140	COG3341	Caulimovirus viroplasmin
BFO_RS02140	COG0328	RNA-DNA hybrid ribonuclease activity
BFO_RS02150	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
BFO_RS02160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BFO_RS02165	COG1160	GTP binding
BFO_RS02170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BFO_RS02175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BFO_RS02190	COG3537	Alpha-1,2-mannosidase
BFO_RS02205	COG3940	Belongs to the glycosyl hydrolase 43 family
BFO_RS02225	COG4946	Tricorn protease homolog
BFO_RS02225	COG1506	peptidase
BFO_RS02225	COG0823	Involved in the tonB-independent uptake of proteins
BFO_RS02235	COG4206	TonB-dependent receptor
BFO_RS02235	COG1629	transport
BFO_RS02265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BFO_RS02270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BFO_RS02285	COG0180	Tryptophanyl-tRNA synthetase
BFO_RS02300	COG0039	L-malate dehydrogenase activity
BFO_RS02305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BFO_RS02310	COG0569	domain protein
BFO_RS02315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BFO_RS02325	COG4206	TonB-dependent receptor
BFO_RS02360	COG1396	sequence-specific DNA binding
BFO_RS02365	COG3550	peptidyl-serine autophosphorylation
BFO_RS02370	COG3550	peptidyl-serine autophosphorylation
BFO_RS02375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BFO_RS02385	COG0556	nucleotide-excision repair
BFO_RS02400	COG3142	Participates in the control of copper homeostasis
BFO_RS02420	COG0438	transferase activity, transferring glycosyl groups
BFO_RS02425	COG0535	radical SAM domain protein
BFO_RS02440	COG3475	LICD family
BFO_RS02450	COG0584	glycerophosphoryl diester phosphodiesterase
BFO_RS02465	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BFO_RS02485	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
BFO_RS02500	COG4585	Histidine kinase
BFO_RS02505	COG2197	response regulator
BFO_RS02570	COG0084	hydrolase, TatD family'
BFO_RS02575	COG0594	ribonuclease P activity
BFO_RS02590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BFO_RS02605	COG4771	TonB-dependent receptor
BFO_RS02630	COG0659	secondary active sulfate transmembrane transporter activity
BFO_RS02635	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BFO_RS02675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BFO_RS02685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BFO_RS02700	COG0793	Belongs to the peptidase S41A family
BFO_RS02710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BFO_RS02715	COG0194	GDP metabolic process
BFO_RS02720	COG1561	YicC-like family, N-terminal region
BFO_RS02790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BFO_RS02810	COG4974	Belongs to the 'phage' integrase family
BFO_RS02815	COG0582	viral genome integration into host DNA
BFO_RS02845	COG1022	Amp-dependent synthetase and ligase
BFO_RS02850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFO_RS02860	COG1215	transferase activity, transferring glycosyl groups
BFO_RS02880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BFO_RS02885	COG0792	nuclease activity
BFO_RS02900	COG3940	Belongs to the glycosyl hydrolase 43 family
BFO_RS02905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BFO_RS02910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BFO_RS02915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BFO_RS02920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BFO_RS02925	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BFO_RS02930	COG0356	it plays a direct role in the translocation of protons across the membrane
BFO_RS02940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BFO_RS02945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BFO_RS02960	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BFO_RS02965	COG1091	dTDP-4-dehydrorhamnose reductase activity
BFO_RS02980	COG0612	Peptidase, M16
BFO_RS02985	COG1696	Membrane protein involved in D-alanine export
BFO_RS03005	COG0443	Heat shock 70 kDa protein
BFO_RS03015	COG4974	Belongs to the 'phage' integrase family
BFO_RS03025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BFO_RS03130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BFO_RS03135	COG3386	PFAM SMP-30 Gluconolaconase
BFO_RS03140	COG0557	exoribonuclease II activity
BFO_RS03160	COG3408	Glycogen debranching enzyme
BFO_RS03165	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
BFO_RS03165	COG0778	Nitroreductase
BFO_RS03175	COG2884	Cell division ATP-binding protein ftsE
BFO_RS03180	COG0527	aspartate kinase activity
BFO_RS03185	COG0019	diaminopimelate decarboxylase activity
BFO_RS03200	COG0673	inositol 2-dehydrogenase activity
BFO_RS03205	COG4771	TonB-dependent receptor
BFO_RS03210	COG0702	epimerase
BFO_RS03215	COG3119	arylsulfatase activity
BFO_RS03240	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BFO_RS03250	COG2986	histidine ammonia-lyase
BFO_RS03280	COG4206	TonB-dependent receptor
BFO_RS03310	COG0793	Belongs to the peptidase S41A family
BFO_RS03315	COG1192	Involved in chromosome partitioning
BFO_RS03320	COG1475	DNA binding
BFO_RS03330	COG3942	CHAP domain
BFO_RS03330	COG1388	LysM domain
BFO_RS03335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BFO_RS03350	COG0739	heme binding
BFO_RS03355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BFO_RS03360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BFO_RS03375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BFO_RS03385	COG3119	arylsulfatase activity
BFO_RS03395	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BFO_RS03410	COG4676	Protein conserved in bacteria
BFO_RS03420	COG1228	amidohydrolase
BFO_RS03430	COG3404	Formiminotransferase-cyclodeaminase
BFO_RS03435	COG2986	histidine ammonia-lyase
BFO_RS03455	COG2996	Protein conserved in bacteria
BFO_RS03480	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BFO_RS03485	COG1136	(ABC) transporter
BFO_RS03490	COG0733	neurotransmitter:sodium symporter activity
BFO_RS03500	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BFO_RS03540	COG0758	DNA mediated transformation
BFO_RS03545	COG2194	sulfuric ester hydrolase activity
BFO_RS03550	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BFO_RS03610	COG1482	cell wall glycoprotein biosynthetic process
BFO_RS03615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BFO_RS03625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFO_RS03630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BFO_RS03640	COG0066	3-isopropylmalate dehydratase activity
BFO_RS03670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFO_RS03680	COG3385	transposase activity
BFO_RS03700	COG0475	glutathione-regulated potassium exporter activity
BFO_RS03710	COG0826	peptidase U32
BFO_RS03715	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BFO_RS03720	COG1546	Belongs to the CinA family
BFO_RS03720	COG1058	Belongs to the CinA family
BFO_RS03725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BFO_RS03745	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BFO_RS03750	COG0540	Belongs to the ATCase OTCase family
BFO_RS03760	COG0641	radical SAM
BFO_RS03790	COG2274	protein secretion by the type I secretion system
BFO_RS03930	COG0745	RESPONSE REGULATOR receiver
BFO_RS03955	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BFO_RS03960	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BFO_RS03980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BFO_RS03985	COG1373	ATPase (AAA superfamily
BFO_RS04015	COG1595	DNA-templated transcription, initiation
BFO_RS04030	COG2204	response regulator
BFO_RS04035	COG0802	atpase or kinase
BFO_RS04045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFO_RS04045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFO_RS04090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BFO_RS04100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BFO_RS04105	COG2715	membrane protein required for spore maturation
BFO_RS04110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BFO_RS04120	COG0495	leucyl-tRNA aminoacylation
BFO_RS04125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BFO_RS04130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BFO_RS04145	COG1022	Amp-dependent synthetase and ligase
BFO_RS04150	COG1280	lysine exporter protein (LysE YggA)
BFO_RS04155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BFO_RS04160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BFO_RS04180	COG0084	hydrolase, TatD family'
BFO_RS04190	COG0811	peptide transport
BFO_RS04210	COG1522	sequence-specific DNA binding
BFO_RS04215	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BFO_RS04220	COG0511	ligase activity, forming carbon-carbon bonds
BFO_RS04230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFO_RS04235	COG0346	lactoylglutathione lyase activity
BFO_RS04240	COG0528	UMP kinase activity
BFO_RS04255	COG4771	TonB-dependent receptor
BFO_RS04260	COG0561	phosphatase activity
BFO_RS04270	COG1482	cell wall glycoprotein biosynthetic process
BFO_RS04275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BFO_RS04295	COG1629	transport
BFO_RS04300	COG0702	epimerase
BFO_RS04325	COG0420	3'-5' exonuclease activity
BFO_RS04335	COG1940	carbohydrate kinase activity
BFO_RS04340	COG1703	isobutyryl-CoA mutase activity
BFO_RS04355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BFO_RS04360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BFO_RS04365	COG2233	PERMEase
BFO_RS04370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BFO_RS04375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFO_RS04375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFO_RS04380	COG0142	geranyltranstransferase activity
BFO_RS04405	COG1506	peptidase
BFO_RS04405	COG0823	Involved in the tonB-independent uptake of proteins
BFO_RS04410	COG0116	Belongs to the methyltransferase superfamily
BFO_RS04430	COG4948	Mandelate Racemase Muconate Lactonizing
BFO_RS04445	COG0731	radical SAM domain protein
BFO_RS04445	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BFO_RS04490	COG2814	Major facilitator Superfamily
BFO_RS04515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BFO_RS04525	COG0517	IMP dehydrogenase activity
BFO_RS04525	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BFO_RS04530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFO_RS04540	COG2195	Cleaves the N-terminal amino acid of tripeptides
BFO_RS04545	COG1185	polyribonucleotide nucleotidyltransferase activity
BFO_RS04560	COG0438	transferase activity, transferring glycosyl groups
BFO_RS04595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BFO_RS04600	COG3177	Filamentation induced by cAMP protein fic
BFO_RS04610	COG0367	asparagine synthase
BFO_RS04635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BFO_RS04645	COG1083	cytidylyl-transferase
BFO_RS04650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BFO_RS04655	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BFO_RS04660	COG2089	acid synthase
BFO_RS04685	COG1028	Short-chain dehydrogenase reductase Sdr
BFO_RS04695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BFO_RS04700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFO_RS04705	COG2244	polysaccharide biosynthetic process
BFO_RS04715	COG0673	inositol 2-dehydrogenase activity
BFO_RS04725	COG3409	Peptidoglycan-binding domain 1 protein
BFO_RS04725	COG0793	Belongs to the peptidase S41A family
BFO_RS04730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BFO_RS04770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BFO_RS04775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFO_RS04780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFO_RS04785	COG0571	ribonuclease III activity
BFO_RS04795	COG0205	6-phosphofructokinase activity
BFO_RS04800	COG0737	Belongs to the 5'-nucleotidase family
BFO_RS04810	COG0445	tRNA wobble uridine modification
BFO_RS04815	COG0322	excinuclease ABC activity
BFO_RS04820	COG1490	D-aminoacyl-tRNA deacylase activity
BFO_RS04825	COG5549	protein import
BFO_RS04825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS04850	COG1234	tRNA 3'-trailer cleavage
BFO_RS04865	COG0509	glycine decarboxylation via glycine cleavage system
BFO_RS04870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BFO_RS04875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BFO_RS04905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BFO_RS04915	COG2204	response regulator
BFO_RS04935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BFO_RS04940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFO_RS04950	COG2076	Multidrug Resistance protein
BFO_RS04960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BFO_RS04970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BFO_RS04995	COG1944	ATP diphosphatase activity
BFO_RS05005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BFO_RS05010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BFO_RS05015	COG3119	arylsulfatase activity
BFO_RS05025	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BFO_RS05040	COG1904	glucuronate isomerase
BFO_RS05045	COG0205	6-phosphofructokinase activity
BFO_RS05080	COG0714	Associated with various cellular activities
BFO_RS05090	COG5549	protein import
BFO_RS05090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS05105	COG5549	protein import
BFO_RS05105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS05140	COG2095	MarC family integral membrane protein
BFO_RS05145	COG0151	Belongs to the GarS family
BFO_RS05170	COG4771	TonB-dependent receptor
BFO_RS05175	COG0702	epimerase
BFO_RS05210	COG4771	TonB-dependent receptor
BFO_RS05260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BFO_RS05275	COG0423	glycine-tRNA ligase activity
BFO_RS05290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BFO_RS05290	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BFO_RS05305	COG4974	Belongs to the 'phage' integrase family
BFO_RS05375	COG0784	Response regulator, receiver
BFO_RS05375	COG2198	Histidine kinase
BFO_RS05375	COG2205	protein histidine kinase activity
BFO_RS05375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFO_RS05610	COG1629	transport
BFO_RS05610	COG4206	TonB-dependent receptor
BFO_RS05635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BFO_RS05640	COG2205	protein histidine kinase activity
BFO_RS05640	COG0745	RESPONSE REGULATOR receiver
BFO_RS05640	COG3292	Two component regulator propeller
BFO_RS05645	COG5434	Belongs to the glycosyl hydrolase 28 family
BFO_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
BFO_RS05660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFO_RS05695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFO_RS05715	COG2096	Adenosyltransferase
BFO_RS05730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BFO_RS05765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BFO_RS05800	COG0233	cytoplasmic translational termination
BFO_RS05805	COG1162	GTPase activity
BFO_RS05810	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BFO_RS05825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BFO_RS05830	COG0280	phosphate acetyltransferase
BFO_RS05835	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BFO_RS05840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BFO_RS05845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BFO_RS05860	COG0826	peptidase U32
BFO_RS05910	COG1012	belongs to the aldehyde dehydrogenase family
BFO_RS05915	COG0813	purine-nucleoside phosphorylase activity
BFO_RS05925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BFO_RS05935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFO_RS05940	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BFO_RS05940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BFO_RS05945	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFO_RS05955	COG0284	orotidine-5'-phosphate decarboxylase activity
BFO_RS05960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BFO_RS05965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BFO_RS05990	COG3956	TIGRFAM MazG family protein
BFO_RS05995	COG3250	beta-galactosidase activity
BFO_RS06030	COG4974	Belongs to the 'phage' integrase family
BFO_RS06040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BFO_RS06045	COG0598	Magnesium transport protein CorA
BFO_RS06050	COG0606	chelatase, subunit chli
BFO_RS06075	COG1629	transport
BFO_RS06075	COG4206	TonB-dependent receptor
BFO_RS06090	COG0463	Glycosyl transferase, family 2
BFO_RS06115	COG4771	TonB-dependent receptor
BFO_RS06135	COG4771	TonB-dependent receptor
BFO_RS06140	COG0012	GTP binding
BFO_RS06205	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFO_RS06215	COG2003	Belongs to the UPF0758 family
BFO_RS06220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BFO_RS06240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BFO_RS06260	COG2890	protein-(glutamine-N5) methyltransferase activity
BFO_RS06265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFO_RS06265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFO_RS06280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BFO_RS06300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BFO_RS06315	COG1121	(ABC) transporter
BFO_RS06320	COG4591	ABC-type transport system involved in lipoprotein release permease component
BFO_RS06325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BFO_RS06335	COG0702	epimerase
BFO_RS06340	COG1629	transport
BFO_RS06365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BFO_RS06385	COG1956	GAF domain-containing protein
BFO_RS06390	COG0617	tRNA 3'-terminal CCA addition
BFO_RS06390	COG0517	IMP dehydrogenase activity
BFO_RS06390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BFO_RS06400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFO_RS06465	COG0427	acetyl-CoA hydrolase
BFO_RS06470	COG1454	alcohol dehydrogenase
BFO_RS06475	COG1012	belongs to the aldehyde dehydrogenase family
BFO_RS06480	COG1960	acyl-CoA dehydrogenase activity
BFO_RS06485	COG2086	electron transfer activity
BFO_RS06490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BFO_RS06500	COG1137	ATPase activity
BFO_RS06505	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BFO_RS06530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFO_RS06535	COG0514	ATP-dependent DNA helicase (RecQ)
BFO_RS06540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BFO_RS06545	COG0740	serine-type endopeptidase activity
BFO_RS06550	COG0544	peptidyl-prolyl cis-trans isomerase activity
BFO_RS06580	COG4206	TonB-dependent receptor
BFO_RS06585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BFO_RS06605	COG0756	dUTP diphosphatase activity
BFO_RS06625	COG4771	TonB-dependent receptor
BFO_RS06640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BFO_RS06660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BFO_RS06670	COG0124	histidyl-tRNA synthetase
BFO_RS06705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BFO_RS06705	COG0551	DNA topoisomerase type I activity
BFO_RS06710	COG1595	DNA-templated transcription, initiation
BFO_RS06720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BFO_RS06725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BFO_RS06730	COG0049	tRNA binding
BFO_RS06735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BFO_RS06740	COG0051	transcription antitermination factor activity, RNA binding
BFO_RS06745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BFO_RS06750	COG0088	Forms part of the polypeptide exit tunnel
BFO_RS06755	COG0089	rRNA binding
BFO_RS06760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BFO_RS06765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BFO_RS06775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BFO_RS06780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BFO_RS06785	COG0255	Belongs to the universal ribosomal protein uL29 family
BFO_RS06790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BFO_RS06795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BFO_RS06800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BFO_RS06805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BFO_RS06810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BFO_RS06815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BFO_RS06820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BFO_RS06825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BFO_RS06830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BFO_RS06835	COG0200	Binds to the 23S rRNA
BFO_RS06840	COG0201	protein transport
BFO_RS06850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BFO_RS06855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BFO_RS06860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BFO_RS06865	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BFO_RS06870	COG0202	RNA polymerase activity
BFO_RS06875	COG0203	ribosomal protein L17
BFO_RS06880	COG1127	ABC transporter
BFO_RS06885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BFO_RS06895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BFO_RS06900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BFO_RS06950	COG0366	Alpha amylase catalytic
BFO_RS06955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BFO_RS06965	COG0482	sulfurtransferase activity
BFO_RS06980	COG4771	TonB-dependent receptor
BFO_RS07040	COG0428	transporter
BFO_RS07050	COG2226	methyltransferase
BFO_RS07055	COG2226	methyltransferase
BFO_RS07070	COG2226	methyltransferase
BFO_RS07085	COG1132	(ABC) transporter
BFO_RS07095	COG1132	(ABC) transporter
BFO_RS07100	COG2066	Belongs to the glutaminase family
BFO_RS07115	COG0196	riboflavin kinase activity
BFO_RS07145	COG0641	radical SAM
BFO_RS07155	COG1053	succinate dehydrogenase
BFO_RS07170	COG0018	arginyl-trna synthetase
BFO_RS07180	COG0525	valine-tRNA ligase activity
BFO_RS07225	COG1242	4 iron, 4 sulfur cluster binding
BFO_RS07235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BFO_RS07260	COG0436	Aminotransferase
BFO_RS07265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BFO_RS07265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BFO_RS07280	COG0779	Required for maturation of 30S ribosomal subunits
BFO_RS07285	COG0195	Participates in both transcription termination and antitermination
BFO_RS07285	COG2251	uridine kinase activity
BFO_RS07290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BFO_RS07300	COG0719	Fe-S assembly protein
BFO_RS07305	COG0396	ATPase activity
BFO_RS07310	COG0719	Fe-S assembly protein
BFO_RS07330	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BFO_RS07335	COG0436	Aminotransferase
BFO_RS07360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BFO_RS07370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BFO_RS07375	COG2166	iron-sulfur cluster assembly
BFO_RS07385	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BFO_RS07390	COG0187	DNA topoisomerase II activity
BFO_RS07470	COG0268	Binds directly to 16S ribosomal RNA
BFO_RS07485	COG4206	TonB-dependent receptor
BFO_RS07485	COG1629	transport
BFO_RS07495	COG4771	TonB-dependent receptor
BFO_RS07505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BFO_RS07515	COG3118	belongs to the thioredoxin family
BFO_RS07545	COG0228	four-way junction DNA binding
BFO_RS07560	COG0514	ATP-dependent DNA helicase (RecQ)
BFO_RS07565	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BFO_RS07565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BFO_RS07575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BFO_RS07585	COG0542	response to heat
BFO_RS07590	COG1253	flavin adenine dinucleotide binding
BFO_RS07595	COG1760	l-serine dehydratase
BFO_RS07600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BFO_RS07605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BFO_RS07610	COG0612	Peptidase, M16
BFO_RS07640	COG1940	carbohydrate kinase activity
BFO_RS07670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BFO_RS07675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BFO_RS07675	COG0674	pyruvate-flavodoxin oxidoreductase activity
BFO_RS07680	COG1013	pyruvate-flavodoxin oxidoreductase activity
BFO_RS07685	COG2177	Part of the ABC transporter FtsEX involved in
BFO_RS07695	COG1968	undecaprenyl-diphosphatase activity
BFO_RS07700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BFO_RS07705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BFO_RS07710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BFO_RS07750	COG1595	DNA-templated transcription, initiation
BFO_RS07765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BFO_RS07770	COG1151	hydroxylamine reductase activity
BFO_RS07775	COG1217	gtp-binding protein TYPA
BFO_RS07780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BFO_RS07785	COG1509	lysine 2,3-aminomutase activity
BFO_RS07800	COG1271	oxidase subunit
BFO_RS07810	COG1595	DNA-templated transcription, initiation
BFO_RS07820	COG1629	transport
BFO_RS07830	COG0673	inositol 2-dehydrogenase activity
BFO_RS07845	COG0612	Peptidase, M16
BFO_RS07850	COG0038	chloride channel
BFO_RS07855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BFO_RS07860	COG0009	L-threonylcarbamoyladenylate synthase
BFO_RS07870	COG0363	glucosamine-6-phosphate deaminase activity
BFO_RS07880	COG0426	domain, Protein
BFO_RS07885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BFO_RS07890	COG0673	inositol 2-dehydrogenase activity
BFO_RS07895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFO_RS07900	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BFO_RS07905	COG0137	argininosuccinate synthase activity
BFO_RS07915	COG1438	arginine binding
BFO_RS07930	COG2211	Major facilitator Superfamily
BFO_RS07940	COG1032	radical SAM domain protein
BFO_RS07955	COG1131	(ABC) transporter
BFO_RS07970	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFO_RS07975	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BFO_RS07980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BFO_RS07985	COG0742	ribosomal rna small subunit methyltransferase
BFO_RS08010	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BFO_RS08020	COG1011	Hydrolase
BFO_RS08025	COG1492	cobalamin metabolic process
BFO_RS08030	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BFO_RS08035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BFO_RS08040	COG0251	oxidation-reduction process
BFO_RS08050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BFO_RS08055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BFO_RS08075	COG3209	COG3209 Rhs family protein
BFO_RS08095	COG3209	COG3209 Rhs family protein
BFO_RS08115	COG3209	COG3209 Rhs family protein
BFO_RS08165	COG0336	Belongs to the RNA methyltransferase TrmD family
BFO_RS08170	COG0072	phenylalanine-tRNA ligase activity
BFO_RS08170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFO_RS08175	COG0217	transcriptional regulatory protein
BFO_RS08200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFO_RS08205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BFO_RS08210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BFO_RS08215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BFO_RS08220	COG0791	NLP P60 protein
BFO_RS08225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BFO_RS08230	COG1408	metallophosphoesterase
BFO_RS08250	COG4139	cobalamin transport
BFO_RS08270	COG0632	four-way junction helicase activity
BFO_RS08280	COG1074	ATP-dependent DNA helicase activity
BFO_RS08285	COG0688	phosphatidylethanolamine metabolic process
BFO_RS08290	COG1183	phosphatidylcholine synthase activity
BFO_RS08300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BFO_RS08340	COG0737	Belongs to the 5'-nucleotidase family
BFO_RS08360	COG0745	RESPONSE REGULATOR receiver
BFO_RS08360	COG2205	protein histidine kinase activity
BFO_RS08360	COG3292	Two component regulator propeller
BFO_RS08365	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BFO_RS08370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BFO_RS08385	COG1381	Involved in DNA repair and RecF pathway recombination
BFO_RS08395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BFO_RS08405	COG2843	Capsule synthesis protein
BFO_RS08410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BFO_RS08415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BFO_RS08420	COG4974	Belongs to the 'phage' integrase family
BFO_RS08440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BFO_RS08455	COG0250	Participates in transcription elongation, termination and antitermination
BFO_RS08460	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BFO_RS08465	COG0081	regulation of translation
BFO_RS08470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BFO_RS08475	COG0222	ribosome binding
BFO_RS08480	COG0085	RNA polymerase activity
BFO_RS08485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BFO_RS08490	COG0433	COG0433 Predicted ATPase
BFO_RS08500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BFO_RS08505	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BFO_RS08510	COG4948	Mandelate Racemase Muconate Lactonizing
BFO_RS08545	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BFO_RS08550	COG4804	nuclease activity
BFO_RS08555	COG0732	type I restriction modification DNA specificity domain
BFO_RS08560	COG4974	Belongs to the 'phage' integrase family
BFO_RS08570	COG0732	type I restriction modification DNA specificity domain
BFO_RS08620	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BFO_RS08685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BFO_RS08730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BFO_RS08740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BFO_RS08740	COG0047	phosphoribosylformylglycinamidine synthase activity
BFO_RS08775	COG1629	transport
BFO_RS08780	COG0702	epimerase
BFO_RS08790	COG4221	oxidoreductase activity
BFO_RS08805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BFO_RS08810	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BFO_RS08810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BFO_RS08815	COG1368	sulfuric ester hydrolase activity
BFO_RS08820	COG1047	Peptidyl-prolyl cis-trans
BFO_RS08825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BFO_RS08830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS08845	COG0750	zinc metalloprotease
BFO_RS08850	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BFO_RS08855	COG4942	peptidase
BFO_RS08860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BFO_RS08875	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BFO_RS08880	COG2183	response to ionizing radiation
BFO_RS08900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BFO_RS08910	COG0488	(ABC) transporter
BFO_RS08915	COG0516	GMP reductase activity
BFO_RS08920	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BFO_RS08920	COG1918	ferrous iron import across plasma membrane
BFO_RS08935	COG3275	phosphorelay sensor kinase activity
BFO_RS08940	COG3279	Response regulator of the LytR AlgR family
BFO_RS09030	COG0148	phosphopyruvate hydratase activity
BFO_RS09040	COG0716	FMN binding
BFO_RS09070	COG4771	TonB-dependent receptor
BFO_RS09075	COG4771	TonB-dependent receptor
BFO_RS09085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BFO_RS09090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BFO_RS09095	COG4886	Leucine-rich repeat (LRR) protein
BFO_RS09135	COG3876	Protein conserved in bacteria
BFO_RS09145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BFO_RS09150	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BFO_RS09155	COG0052	Belongs to the universal ribosomal protein uS2 family
BFO_RS09160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BFO_RS09205	COG1629	transport
BFO_RS09225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BFO_RS09225	COG4651	solute:proton antiporter activity
BFO_RS09235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BFO_RS09255	COG1418	mRNA catabolic process
BFO_RS09260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BFO_RS09265	COG0488	(ABC) transporter
BFO_RS09285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BFO_RS09315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BFO_RS09330	COG3876	Protein conserved in bacteria
BFO_RS09335	COG2871	sodium ion transport
BFO_RS09340	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BFO_RS09345	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BFO_RS09350	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BFO_RS09355	COG1805	sodium ion transport
BFO_RS09360	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BFO_RS09370	COG0739	heme binding
BFO_RS09375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BFO_RS09380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BFO_RS09385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BFO_RS09390	COG0563	adenylate kinase activity
BFO_RS09400	COG3845	ABC transporter
BFO_RS09410	COG0346	lactoylglutathione lyase activity
BFO_RS09425	COG0463	Glycosyl transferase, family 2
BFO_RS09435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BFO_RS09440	COG4452	Inner membrane protein CreD
BFO_RS09480	COG1028	Short-chain dehydrogenase reductase Sdr
BFO_RS09485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BFO_RS09490	COG1309	transcriptional regulator
BFO_RS09520	COG1472	Belongs to the glycosyl hydrolase 3 family
BFO_RS09525	COG2885	chlorophyll binding
BFO_RS09535	COG0542	response to heat
BFO_RS09590	COG2271	Major facilitator Superfamily
BFO_RS09595	COG4771	TonB-dependent receptor
BFO_RS09600	COG0702	epimerase
BFO_RS09610	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BFO_RS09640	COG4822	anaerobic cobalamin biosynthetic process
BFO_RS09655	COG4771	TonB-dependent receptor
BFO_RS09660	COG1477	protein flavinylation
BFO_RS09670	COG1480	7TM receptor with intracellular HD hydrolase
BFO_RS09790	COG1072	(Pantothenic acid kinase))
BFO_RS09810	COG1131	(ABC) transporter
BFO_RS09815	COG1131	(ABC) transporter
BFO_RS09820	COG0842	Transport permease protein
BFO_RS09845	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BFO_RS09850	COG4206	TonB-dependent receptor
BFO_RS09850	COG1629	transport
BFO_RS09855	COG1082	Xylose isomerase domain protein TIM barrel
BFO_RS09865	COG0343	queuine tRNA-ribosyltransferase activity
BFO_RS09875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BFO_RS09885	COG1773	rubredoxin
BFO_RS09890	COG0583	DNA-binding transcription factor activity
BFO_RS09900	COG0668	transmembrane transport
BFO_RS09905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BFO_RS09915	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BFO_RS09920	COG4771	TonB-dependent receptor
BFO_RS09930	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BFO_RS09935	COG4677	pectinesterase activity
BFO_RS09940	COG3119	arylsulfatase activity
BFO_RS09955	COG1028	Short-chain dehydrogenase reductase Sdr
BFO_RS09965	COG2271	Major facilitator Superfamily
BFO_RS09980	COG0577	efflux transmembrane transporter activity
BFO_RS10055	COG1570	exodeoxyribonuclease VII activity
BFO_RS10065	COG2502	aspartate--ammonia ligase
BFO_RS10075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BFO_RS10075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BFO_RS10080	COG1752	Esterase of the alpha-beta hydrolase superfamily
BFO_RS10090	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BFO_RS10145	COG3177	Filamentation induced by cAMP protein fic
BFO_RS10160	COG1353	crispr-associated protein
BFO_RS10170	COG1337	RAMP superfamily
BFO_RS10195	COG1518	maintenance of DNA repeat elements
BFO_RS10200	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BFO_RS10225	COG1528	Iron-storage protein
BFO_RS10230	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BFO_RS10245	COG0776	regulation of translation
BFO_RS10250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BFO_RS10260	COG1640	4-alpha-glucanotransferase
BFO_RS10280	COG4589	Belongs to the CDS family
BFO_RS10285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BFO_RS10290	COG0799	negative regulation of ribosome biogenesis
BFO_RS10320	COG1629	transport
BFO_RS10350	COG0285	dihydrofolate synthase activity
BFO_RS10355	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BFO_RS10365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BFO_RS10420	COG0497	DNA recombination
BFO_RS10425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFO_RS10430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BFO_RS10435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BFO_RS10440	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BFO_RS10445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BFO_RS10455	COG2195	Cleaves the N-terminal amino acid of tripeptides
BFO_RS10470	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BFO_RS10475	COG1979	alcohol dehydrogenase
BFO_RS10495	COG3250	beta-galactosidase activity
BFO_RS10500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFO_RS10515	COG0470	DNA polymerase III
BFO_RS10520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BFO_RS10530	COG0534	Mate efflux family protein
BFO_RS10535	COG4771	TonB-dependent receptor
BFO_RS10570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BFO_RS10575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BFO_RS10580	COG1748	Saccharopine dehydrogenase
BFO_RS10595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BFO_RS10600	COG1215	transferase activity, transferring glycosyl groups
BFO_RS10665	COG3209	COG3209 Rhs family protein
BFO_RS10710	COG1629	transport
BFO_RS10710	COG4206	TonB-dependent receptor
BFO_RS10740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BFO_RS10750	COG0739	heme binding
BFO_RS10765	COG0149	triose-phosphate isomerase activity
BFO_RS10775	COG0302	gtp cyclohydrolase
BFO_RS10780	COG0009	L-threonylcarbamoyladenylate synthase
BFO_RS10795	COG4690	dipeptidase activity
BFO_RS10820	COG0545	Peptidyl-prolyl cis-trans isomerase
BFO_RS10825	COG0545	Peptidyl-prolyl cis-trans isomerase
BFO_RS10865	COG1629	transport
BFO_RS10865	COG4206	TonB-dependent receptor
BFO_RS10880	COG0823	Involved in the tonB-independent uptake of proteins
BFO_RS10890	COG0463	Glycosyl transferase, family 2
BFO_RS10895	COG1649	PFAM Uncharacterised BCR, COG1649
BFO_RS10900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFO_RS10910	COG0860	N-Acetylmuramoyl-L-alanine amidase
BFO_RS10910	COG1388	LysM domain
BFO_RS10920	COG1388	LysM domain
BFO_RS10920	COG0741	lytic transglycosylase activity
BFO_RS10925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BFO_RS10935	COG1739	Uncharacterized protein family UPF0029
BFO_RS10945	COG0006	proline dipeptidase activity
BFO_RS10950	COG1785	Belongs to the alkaline phosphatase family
BFO_RS10965	COG5549	protein import
BFO_RS10965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS10975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS10975	COG5549	protein import
BFO_RS11020	COG5549	protein import
BFO_RS11020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS11055	COG1649	PFAM Uncharacterised BCR, COG1649
BFO_RS11065	COG0492	ferredoxin-NADP+ reductase activity
BFO_RS11075	COG1674	ftsk spoiiie
BFO_RS11080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BFO_RS11085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BFO_RS11095	COG0037	tRNA processing
BFO_RS11115	COG2197	response regulator
BFO_RS11125	COG2966	Psort location CytoplasmicMembrane, score
BFO_RS11155	COG1620	l-lactate permease
BFO_RS11160	COG1556	Lactate utilization protein
BFO_RS11165	COG1139	Iron-sulfur cluster binding protein
BFO_RS11205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BFO_RS11210	COG0321	lipoyl(octanoyl) transferase activity
BFO_RS11220	COG1774	PSP1 C-terminal conserved region
BFO_RS11225	COG0156	8-amino-7-oxononanoate synthase activity
BFO_RS11230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BFO_RS11240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFO_RS11245	COG0402	S-adenosylhomocysteine deaminase activity
BFO_RS11285	COG4206	TonB-dependent receptor
BFO_RS11285	COG1629	transport
BFO_RS11290	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BFO_RS11300	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFO_RS11305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFO_RS11305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFO_RS11310	COG0488	(ABC) transporter
BFO_RS11320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BFO_RS11325	COG0706	membrane insertase activity
BFO_RS11330	COG0504	CTP synthase activity
BFO_RS11335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BFO_RS11350	COG2878	Part of a membrane complex involved in electron transport
BFO_RS11350	COG1245	4Fe-4S binding domain
BFO_RS11355	COG4656	Part of a membrane complex involved in electron transport
BFO_RS11360	COG4658	electron transport chain
BFO_RS11365	COG4659	FMN binding
BFO_RS11370	COG4660	Part of a membrane complex involved in electron transport
BFO_RS11375	COG4657	Part of a membrane complex involved in electron transport
BFO_RS11410	COG2252	PERMEase
BFO_RS11430	COG3119	arylsulfatase activity
BFO_RS11440	COG2096	Adenosyltransferase
BFO_RS11460	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BFO_RS11485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFO_RS11505	COG3104	oligopeptide transport
BFO_RS11530	COG4206	TonB-dependent receptor
BFO_RS11530	COG1629	transport
BFO_RS11555	COG2115	Belongs to the xylose isomerase family
BFO_RS11560	COG0477	Major facilitator Superfamily
BFO_RS11560	COG2814	Major facilitator Superfamily
BFO_RS11580	COG4771	TonB-dependent receptor
BFO_RS11635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BFO_RS11640	COG1032	radical SAM domain protein
BFO_RS11645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BFO_RS11650	COG0513	Belongs to the DEAD box helicase family
BFO_RS11705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BFO_RS11710	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BFO_RS11715	COG1663	tetraacyldisaccharide 4'-kinase activity
BFO_RS11720	COG0616	signal peptide processing
BFO_RS11725	COG0534	Mate efflux family protein
BFO_RS11735	COG1505	serine-type exopeptidase activity
BFO_RS11740	COG0745	RESPONSE REGULATOR receiver
BFO_RS11740	COG2205	protein histidine kinase activity
BFO_RS11740	COG3292	Two component regulator propeller
BFO_RS11795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BFO_RS11795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BFO_RS11800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFO_RS11805	COG0357	Ribosomal RNA small subunit methyltransferase G
BFO_RS11815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BFO_RS11835	COG0671	phosphoesterase, PA-phosphatase related
BFO_RS11855	COG2304	oxidoreductase activity
BFO_RS11860	COG2304	oxidoreductase activity
BFO_RS11875	COG0714	Associated with various cellular activities
BFO_RS11885	COG0776	regulation of translation
BFO_RS11890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFO_RS11895	COG0552	protein localization to endoplasmic reticulum
BFO_RS11940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BFO_RS11960	COG1530	ribonuclease E activity
BFO_RS11965	COG0776	regulation of translation
BFO_RS11975	COG0629	single-stranded DNA binding
BFO_RS12015	COG0702	epimerase
BFO_RS12020	COG4206	TonB-dependent receptor
BFO_RS12020	COG1629	transport
BFO_RS12035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFO_RS12040	COG0671	phosphoesterase, PA-phosphatase related
BFO_RS12065	COG0673	inositol 2-dehydrogenase activity
BFO_RS12070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BFO_RS12075	COG2195	Cleaves the N-terminal amino acid of tripeptides
BFO_RS12085	COG0463	Glycosyl transferase, family 2
BFO_RS12100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BFO_RS12110	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BFO_RS12120	COG1611	Belongs to the LOG family
BFO_RS12125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BFO_RS12140	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BFO_RS12155	COG3537	Alpha-1,2-mannosidase
BFO_RS12160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BFO_RS12165	COG2226	methyltransferase
BFO_RS12170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BFO_RS12185	COG0006	proline dipeptidase activity
BFO_RS12240	COG3250	beta-galactosidase activity
BFO_RS12250	COG0481	GTPase activity
BFO_RS12255	COG4771	TonB-dependent receptor
BFO_RS12260	COG0702	epimerase
BFO_RS12265	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BFO_RS12270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BFO_RS12275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BFO_RS12275	COG0574	Belongs to the PEP-utilizing enzyme family
BFO_RS12320	COG1629	transport
BFO_RS12320	COG4206	TonB-dependent receptor
BFO_RS12340	COG0156	8-amino-7-oxononanoate synthase activity
BFO_RS12365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BFO_RS12385	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BFO_RS12415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BFO_RS12420	COG0489	protein tyrosine kinase activity
BFO_RS12425	COG0793	Belongs to the peptidase S41A family
BFO_RS12430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFO_RS12460	COG2194	sulfuric ester hydrolase activity
BFO_RS12500	COG0300	oxidoreductase activity
BFO_RS12510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BFO_RS12520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BFO_RS12525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFO_RS12550	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
BFO_RS12555	COG0653	protein targeting
BFO_RS12560	COG0745	RESPONSE REGULATOR receiver
BFO_RS12560	COG3292	Two component regulator propeller
BFO_RS12560	COG2205	protein histidine kinase activity
BFO_RS12570	COG0242	peptide deformylase activity
BFO_RS12575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BFO_RS12580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BFO_RS12590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BFO_RS12595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BFO_RS12605	COG0436	Aminotransferase
BFO_RS12615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFO_RS12625	COG1678	Uncharacterized ACR, COG1678
BFO_RS12630	COG2873	o-acetylhomoserine
BFO_RS12635	COG1668	transmembrane transport
BFO_RS12640	COG4152	abc transporter atp-binding protein
BFO_RS12645	COG0358	DNA primase activity
BFO_RS12710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BFO_RS12725	COG0823	Involved in the tonB-independent uptake of proteins
BFO_RS12725	COG1506	peptidase
BFO_RS12730	COG0424	maF-like protein
BFO_RS12735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFO_RS12750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BFO_RS12755	COG0193	aminoacyl-tRNA hydrolase activity
BFO_RS12760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BFO_RS12805	COG0681	Belongs to the peptidase S26 family
BFO_RS12810	COG1132	(ABC) transporter
BFO_RS12825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFO_RS12840	COG1575	Belongs to the MenA family. Type 1 subfamily
BFO_RS12845	COG4771	TonB-dependent receptor
BFO_RS12875	COG0848	biopolymer transport protein
BFO_RS12880	COG0811	peptide transport
BFO_RS12885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BFO_RS12890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BFO_RS12925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BFO_RS12930	COG2268	Band 7 protein
BFO_RS12950	COG2985	domain, Protein
BFO_RS12950	COG0490	domain, Protein
BFO_RS13020	COG1295	ribonuclease BN
BFO_RS13025	COG0527	aspartate kinase activity
BFO_RS13025	COG0460	homoserine dehydrogenase
BFO_RS13030	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
BFO_RS13040	COG0363	glucosamine-6-phosphate deaminase activity
BFO_RS13045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BFO_RS13080	COG2832	Protein of unknown function (DUF454)
BFO_RS13100	COG0318	PFAM AMP-dependent synthetase and ligase
BFO_RS13110	COG2801	Transposase and inactivated derivatives
BFO_RS13190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFO_RS13195	COG4948	Mandelate Racemase Muconate Lactonizing
BFO_RS13200	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BFO_RS13205	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BFO_RS13220	COG1373	ATPase (AAA superfamily
BFO_RS13245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BFO_RS13245	COG0731	radical SAM domain protein
BFO_RS13370	COG4974	Belongs to the 'phage' integrase family
BFO_RS13405	COG3645	SOS response
BFO_RS13425	COG2207	Transcriptional regulator
BFO_RS13425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BFO_RS13450	COG1373	ATPase (AAA superfamily
BFO_RS13480	COG1196	nuclear chromosome segregation
BFO_RS13495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BFO_RS13560	COG0564	pseudouridine synthase activity
BFO_RS13565	COG1181	Belongs to the D-alanine--D-alanine ligase family
BFO_RS13575	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BFO_RS13580	COG0179	Fumarylacetoacetate (FAA) hydrolase
BFO_RS13600	COG0793	Belongs to the peptidase S41A family
BFO_RS13600	COG4946	Tricorn protease homolog
BFO_RS13605	COG3250	beta-galactosidase activity
BFO_RS13615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BFO_RS13640	COG0058	SHG alpha-glucan phosphorylase activity
BFO_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
BFO_RS13670	COG3022	response to hydroperoxide
BFO_RS13680	COG1629	transport
BFO_RS13685	COG0702	epimerase
BFO_RS13720	COG4771	TonB-dependent receptor
BFO_RS13745	COG0254	rRNA binding
BFO_RS13750	COG0191	fructose-bisphosphate aldolase activity
BFO_RS13755	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BFO_RS13775	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BFO_RS13805	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BFO_RS13810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFO_RS13815	COG0805	protein transport
BFO_RS13820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BFO_RS13825	COG0305	Participates in initiation and elongation during chromosome replication
BFO_RS13835	COG0488	(ABC) transporter
BFO_RS13840	COG0138	bifunctional purine biosynthesis protein purh
BFO_RS13865	COG0772	Belongs to the SEDS family
BFO_RS13870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BFO_RS13875	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BFO_RS13880	COG0166	Belongs to the GPI family
BFO_RS13890	COG0360	Binds together with S18 to 16S ribosomal RNA
BFO_RS13895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BFO_RS13900	COG0359	binds to the 23S rRNA
BFO_RS13905	COG0860	N-Acetylmuramoyl-L-alanine amidase
BFO_RS14020	COG4206	TonB-dependent receptor
BFO_RS14020	COG1629	transport
BFO_RS14320	COG3152	Membrane
BFO_RS14340	COG5549	protein import
BFO_RS14340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS14385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS14385	COG5549	protein import
BFO_RS14390	COG4771	TonB-dependent receptor
BFO_RS14395	COG4206	TonB-dependent receptor
BFO_RS14395	COG1629	transport
BFO_RS14405	COG1629	transport
BFO_RS14405	COG4206	TonB-dependent receptor
BFO_RS14410	COG1404	Belongs to the peptidase S8 family
BFO_RS14420	COG5492	domain, Protein
BFO_RS14440	COG3209	COG3209 Rhs family protein
BFO_RS14445	COG3209	COG3209 Rhs family protein
BFO_RS14550	COG5549	protein import
BFO_RS14550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS14555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_RS14555	COG5549	protein import
BFO_RS14620	COG1309	transcriptional regulator