locus-tag	class	description
TFKS16_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TFKS16_RS00025	COG0335	large ribosomal subunit rRNA binding
TFKS16_RS00045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TFKS16_RS00060	COG3590	peptidase
TFKS16_RS00075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TFKS16_RS00080	COG1120	ATPase activity
TFKS16_RS00095	COG0543	2 iron, 2 sulfur cluster binding
TFKS16_RS00100	COG0167	dihydroorotate dehydrogenase activity
TFKS16_RS00115	COG1285	pathogenesis
TFKS16_RS00125	COG0101	tRNA pseudouridine synthase activity
TFKS16_RS00135	COG1797	cobyrinic acid a,c-diamide synthase activity
TFKS16_RS00140	COG3250	beta-galactosidase activity
TFKS16_RS00140	COG5297	Belongs to the glycosyl hydrolase family 6
TFKS16_RS00150	COG1629	transport
TFKS16_RS00150	COG4206	TonB-dependent receptor
TFKS16_RS00165	COG1629	transport
TFKS16_RS00180	COG1215	transferase activity, transferring glycosyl groups
TFKS16_RS00190	COG2385	sporulation resulting in formation of a cellular spore
TFKS16_RS00190	COG2247	cell wall binding repeat
TFKS16_RS00195	COG2211	Major facilitator Superfamily
TFKS16_RS00200	COG3876	Protein conserved in bacteria
TFKS16_RS00220	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TFKS16_RS00225	COG0561	phosphatase activity
TFKS16_RS00280	COG0641	radical SAM
TFKS16_RS00440	COG3617	BRO family, N-terminal domain
TFKS16_RS00450	COG0175	sulfate reduction
TFKS16_RS00555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TFKS16_RS00595	COG2274	protein secretion by the type I secretion system
TFKS16_RS00615	COG0438	transferase activity, transferring glycosyl groups
TFKS16_RS00665	COG2274	protein secretion by the type I secretion system
TFKS16_RS00705	COG1187	pseudouridine synthase activity
TFKS16_RS00730	COG1132	(ABC) transporter
TFKS16_RS00735	COG1132	(ABC) transporter
TFKS16_RS00745	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
TFKS16_RS00760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TFKS16_RS00780	COG2223	nitrite transmembrane transporter activity
TFKS16_RS00785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TFKS16_RS00795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TFKS16_RS00800	COG0543	2 iron, 2 sulfur cluster binding
TFKS16_RS00805	COG0493	'glutamate synthase
TFKS16_RS00810	COG3015	lipoprotein NlpE involved in copper resistance
TFKS16_RS00815	COG1051	belongs to the nudix hydrolase family
TFKS16_RS00820	COG1970	mechanosensitive ion channel activity
TFKS16_RS00825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TFKS16_RS00835	COG2972	Histidine kinase
TFKS16_RS00835	COG0745	RESPONSE REGULATOR receiver
TFKS16_RS00855	COG1136	(ABC) transporter
TFKS16_RS00855	COG4591	ABC-type transport system involved in lipoprotein release permease component
TFKS16_RS00930	COG0438	transferase activity, transferring glycosyl groups
TFKS16_RS00940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TFKS16_RS00955	COG0237	dephospho-CoA kinase activity
TFKS16_RS00965	COG1862	Preprotein translocase
TFKS16_RS00970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TFKS16_RS00975	COG0252	asparaginase activity
TFKS16_RS00995	COG1629	transport
TFKS16_RS01030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TFKS16_RS01040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TFKS16_RS01050	COG1011	Hydrolase
TFKS16_RS01055	COG1595	DNA-templated transcription, initiation
TFKS16_RS01120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TFKS16_RS01130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TFKS16_RS01135	COG0235	Class ii aldolase
TFKS16_RS01145	COG4806	L-rhamnose isomerase
TFKS16_RS01150	COG1070	Carbohydrate kinase
TFKS16_RS01165	COG0442	prolyl-tRNA aminoacylation
TFKS16_RS01170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TFKS16_RS01180	COG1704	LemA family
TFKS16_RS01185	COG0501	Belongs to the peptidase M48B family
TFKS16_RS01190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TFKS16_RS01195	COG0126	phosphoglycerate kinase activity
TFKS16_RS01200	COG0534	Mate efflux family protein
TFKS16_RS01240	COG0484	heat shock protein binding
TFKS16_RS01245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TFKS16_RS01250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS01255	COG1193	negative regulation of DNA recombination
TFKS16_RS01265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TFKS16_RS01275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TFKS16_RS01300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TFKS16_RS01310	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TFKS16_RS01325	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TFKS16_RS01330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TFKS16_RS01340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TFKS16_RS01360	COG2264	protein methyltransferase activity
TFKS16_RS01370	COG2197	response regulator
TFKS16_RS01380	COG1373	ATPase (AAA superfamily
TFKS16_RS01385	COG4804	nuclease activity
TFKS16_RS01410	COG3152	Membrane
TFKS16_RS01450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TFKS16_RS01455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TFKS16_RS01460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TFKS16_RS01490	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
TFKS16_RS01495	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TFKS16_RS01510	COG4771	TonB-dependent receptor
TFKS16_RS01515	COG0702	epimerase
TFKS16_RS01520	COG3250	beta-galactosidase activity
TFKS16_RS01530	COG2431	L-lysine efflux transmembrane transporter activity
TFKS16_RS01535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TFKS16_RS01540	COG3339	Conserved Protein
TFKS16_RS01550	COG0738	Major facilitator superfamily
TFKS16_RS01555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TFKS16_RS01555	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TFKS16_RS01560	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TFKS16_RS01565	COG2885	chlorophyll binding
TFKS16_RS01570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TFKS16_RS01570	COG1333	cytochrome c biogenesis protein
TFKS16_RS01575	COG1506	peptidase
TFKS16_RS01575	COG0823	Involved in the tonB-independent uptake of proteins
TFKS16_RS01585	COG3537	Alpha-1,2-mannosidase
TFKS16_RS01595	COG0534	Mate efflux family protein
TFKS16_RS01600	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TFKS16_RS01605	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TFKS16_RS01610	COG0297	glycogen (starch) synthase activity
TFKS16_RS01680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TFKS16_RS01715	COG1561	YicC-like family, N-terminal region
TFKS16_RS01720	COG0194	GDP metabolic process
TFKS16_RS01725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TFKS16_RS01735	COG0793	Belongs to the peptidase S41A family
TFKS16_RS01750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TFKS16_RS01760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TFKS16_RS01795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TFKS16_RS01800	COG0659	secondary active sulfate transmembrane transporter activity
TFKS16_RS01815	COG4771	TonB-dependent receptor
TFKS16_RS01845	COG0594	ribonuclease P activity
TFKS16_RS01850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TFKS16_RS01855	COG0084	hydrolase, TatD family'
TFKS16_RS01920	COG2197	response regulator
TFKS16_RS01925	COG4585	Histidine kinase
TFKS16_RS01940	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TFKS16_RS01960	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TFKS16_RS01975	COG0584	glycerophosphoryl diester phosphodiesterase
TFKS16_RS01985	COG3475	LICD family
TFKS16_RS02000	COG0535	radical SAM domain protein
TFKS16_RS02025	COG3142	Participates in the control of copper homeostasis
TFKS16_RS02040	COG0556	nucleotide-excision repair
TFKS16_RS02050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TFKS16_RS02055	COG3550	peptidyl-serine autophosphorylation
TFKS16_RS02060	COG3550	peptidyl-serine autophosphorylation
TFKS16_RS02065	COG1396	sequence-specific DNA binding
TFKS16_RS02095	COG4206	TonB-dependent receptor
TFKS16_RS02105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TFKS16_RS02110	COG0569	domain protein
TFKS16_RS02115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TFKS16_RS02120	COG0039	L-malate dehydrogenase activity
TFKS16_RS02135	COG0180	Tryptophanyl-tRNA synthetase
TFKS16_RS02150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TFKS16_RS02155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TFKS16_RS02185	COG1629	transport
TFKS16_RS02185	COG4206	TonB-dependent receptor
TFKS16_RS02195	COG4946	Tricorn protease homolog
TFKS16_RS02195	COG1506	peptidase
TFKS16_RS02195	COG0823	Involved in the tonB-independent uptake of proteins
TFKS16_RS02205	COG4771	TonB-dependent receptor
TFKS16_RS02215	COG3940	Belongs to the glycosyl hydrolase 43 family
TFKS16_RS02230	COG3537	Alpha-1,2-mannosidase
TFKS16_RS02240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TFKS16_RS02245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TFKS16_RS02250	COG1160	GTP binding
TFKS16_RS02255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TFKS16_RS02265	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
TFKS16_RS02275	COG0328	RNA-DNA hybrid ribonuclease activity
TFKS16_RS02275	COG3341	Caulimovirus viroplasmin
TFKS16_RS02280	COG0438	transferase activity, transferring glycosyl groups
TFKS16_RS02290	COG0165	Argininosuccinate lyase
TFKS16_RS02300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TFKS16_RS02305	COG2373	Large extracellular alpha-helical protein
TFKS16_RS02310	COG4953	penicillin-binding protein 1C
TFKS16_RS02320	COG0366	Alpha amylase catalytic
TFKS16_RS02325	COG1136	(ABC) transporter
TFKS16_RS02330	COG1136	(ABC) transporter
TFKS16_RS02330	COG0577	efflux transmembrane transporter activity
TFKS16_RS02360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TFKS16_RS02365	COG0363	glucosamine-6-phosphate deaminase activity
TFKS16_RS02385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TFKS16_RS02390	COG3250	beta-galactosidase activity
TFKS16_RS02400	COG0312	modulator of DNA gyrase
TFKS16_RS02415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TFKS16_RS02420	COG0534	Mate efflux family protein
TFKS16_RS02425	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TFKS16_RS02430	COG0501	Belongs to the peptidase M48B family
TFKS16_RS02435	COG4886	Leucine-rich repeat (LRR) protein
TFKS16_RS02445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TFKS16_RS02445	COG0519	Catalyzes the synthesis of GMP from XMP
TFKS16_RS02470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS02475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TFKS16_RS02480	COG0658	competence protein
TFKS16_RS02480	COG2333	competence protein COMEC
TFKS16_RS02485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TFKS16_RS02495	COG1595	DNA-templated transcription, initiation
TFKS16_RS02535	COG0546	phosphoglycolate phosphatase activity
TFKS16_RS02540	COG0427	acetyl-CoA hydrolase
TFKS16_RS02545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TFKS16_RS02550	COG0698	ribose 5-phosphate isomerase
TFKS16_RS02565	COG0275	rRNA processing
TFKS16_RS02575	COG0768	penicillin binding
TFKS16_RS02580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TFKS16_RS02585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TFKS16_RS02590	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TFKS16_RS02595	COG0772	Belongs to the SEDS family
TFKS16_RS02600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TFKS16_RS02605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TFKS16_RS02620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TFKS16_RS02625	COG1610	YqeY-like protein
TFKS16_RS02635	COG4771	TonB-dependent receptor
TFKS16_RS02640	COG2860	membrane
TFKS16_RS02690	COG2255	four-way junction helicase activity
TFKS16_RS02705	COG3591	Belongs to the peptidase S1B family
TFKS16_RS02710	COG1216	Glycosyl transferase, family 2
TFKS16_RS02710	COG0463	Glycosyl transferase, family 2
TFKS16_RS02730	COG0681	Belongs to the peptidase S26 family
TFKS16_RS02785	COG0681	Belongs to the peptidase S26 family
TFKS16_RS02835	COG1022	Amp-dependent synthetase and ligase
TFKS16_RS02840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TFKS16_RS02850	COG1215	transferase activity, transferring glycosyl groups
TFKS16_RS02870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TFKS16_RS02875	COG0792	nuclease activity
TFKS16_RS02890	COG3940	Belongs to the glycosyl hydrolase 43 family
TFKS16_RS02895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TFKS16_RS02900	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TFKS16_RS02905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TFKS16_RS02910	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TFKS16_RS02915	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TFKS16_RS02920	COG0356	it plays a direct role in the translocation of protons across the membrane
TFKS16_RS02930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TFKS16_RS02935	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TFKS16_RS02950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TFKS16_RS02955	COG1091	dTDP-4-dehydrorhamnose reductase activity
TFKS16_RS02970	COG0612	Peptidase, M16
TFKS16_RS02975	COG1696	Membrane protein involved in D-alanine export
TFKS16_RS02995	COG0443	Heat shock 70 kDa protein
TFKS16_RS03005	COG4974	Belongs to the 'phage' integrase family
TFKS16_RS03050	COG1476	TRANSCRIPTIONal
TFKS16_RS03125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS03125	COG5549	protein import
TFKS16_RS03130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TFKS16_RS03135	COG3386	PFAM SMP-30 Gluconolaconase
TFKS16_RS03140	COG0557	exoribonuclease II activity
TFKS16_RS03160	COG3408	Glycogen debranching enzyme
TFKS16_RS03165	COG0778	Nitroreductase
TFKS16_RS03165	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TFKS16_RS03175	COG2884	Cell division ATP-binding protein ftsE
TFKS16_RS03180	COG0527	aspartate kinase activity
TFKS16_RS03185	COG0019	diaminopimelate decarboxylase activity
TFKS16_RS03200	COG0673	inositol 2-dehydrogenase activity
TFKS16_RS03205	COG4771	TonB-dependent receptor
TFKS16_RS03210	COG0702	epimerase
TFKS16_RS03215	COG3119	arylsulfatase activity
TFKS16_RS03230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TFKS16_RS03235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TFKS16_RS03245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TFKS16_RS03250	COG1127	ABC transporter
TFKS16_RS03255	COG0203	ribosomal protein L17
TFKS16_RS03260	COG0202	RNA polymerase activity
TFKS16_RS03265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TFKS16_RS03270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TFKS16_RS03275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TFKS16_RS03280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TFKS16_RS03290	COG0201	protein transport
TFKS16_RS03295	COG0200	Binds to the 23S rRNA
TFKS16_RS03300	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TFKS16_RS03305	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TFKS16_RS03310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TFKS16_RS03315	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TFKS16_RS03320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TFKS16_RS03325	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TFKS16_RS03330	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TFKS16_RS03335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TFKS16_RS03340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TFKS16_RS03345	COG0255	Belongs to the universal ribosomal protein uL29 family
TFKS16_RS03350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TFKS16_RS03355	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TFKS16_RS03365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TFKS16_RS03370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TFKS16_RS03375	COG0089	rRNA binding
TFKS16_RS03380	COG0088	Forms part of the polypeptide exit tunnel
TFKS16_RS03385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TFKS16_RS03390	COG0051	transcription antitermination factor activity, RNA binding
TFKS16_RS03395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TFKS16_RS03400	COG0049	tRNA binding
TFKS16_RS03405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TFKS16_RS03410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TFKS16_RS03420	COG1595	DNA-templated transcription, initiation
TFKS16_RS03425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TFKS16_RS03425	COG0551	DNA topoisomerase type I activity
TFKS16_RS03430	COG3385	transposase activity
TFKS16_RS03465	COG0124	histidyl-tRNA synthetase
TFKS16_RS03475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TFKS16_RS03495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TFKS16_RS03510	COG4771	TonB-dependent receptor
TFKS16_RS03530	COG0756	dUTP diphosphatase activity
TFKS16_RS03550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TFKS16_RS03555	COG4206	TonB-dependent receptor
TFKS16_RS03585	COG0544	peptidyl-prolyl cis-trans isomerase activity
TFKS16_RS03590	COG0740	serine-type endopeptidase activity
TFKS16_RS03595	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TFKS16_RS03600	COG0514	ATP-dependent DNA helicase (RecQ)
TFKS16_RS03605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TFKS16_RS03630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TFKS16_RS03635	COG1137	ATPase activity
TFKS16_RS03645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TFKS16_RS03650	COG2086	electron transfer activity
TFKS16_RS03655	COG1960	acyl-CoA dehydrogenase activity
TFKS16_RS03660	COG1012	belongs to the aldehyde dehydrogenase family
TFKS16_RS03665	COG1454	alcohol dehydrogenase
TFKS16_RS03670	COG0427	acetyl-CoA hydrolase
TFKS16_RS03700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TFKS16_RS03710	COG0617	tRNA 3'-terminal CCA addition
TFKS16_RS03710	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TFKS16_RS03710	COG0517	IMP dehydrogenase activity
TFKS16_RS03715	COG1956	GAF domain-containing protein
TFKS16_RS03735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TFKS16_RS03760	COG1629	transport
TFKS16_RS03765	COG0702	epimerase
TFKS16_RS03775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TFKS16_RS03780	COG4591	ABC-type transport system involved in lipoprotein release permease component
TFKS16_RS03785	COG1121	(ABC) transporter
TFKS16_RS03800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TFKS16_RS03820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TFKS16_RS03835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TFKS16_RS03835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TFKS16_RS03840	COG2890	protein-(glutamine-N5) methyltransferase activity
TFKS16_RS03860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TFKS16_RS03875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TFKS16_RS03880	COG2003	Belongs to the UPF0758 family
TFKS16_RS03890	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TFKS16_RS03965	COG0012	GTP binding
TFKS16_RS03970	COG4771	TonB-dependent receptor
TFKS16_RS03995	COG4771	TonB-dependent receptor
TFKS16_RS04020	COG0463	Glycosyl transferase, family 2
TFKS16_RS04035	COG4206	TonB-dependent receptor
TFKS16_RS04035	COG1629	transport
TFKS16_RS04060	COG0606	chelatase, subunit chli
TFKS16_RS04065	COG0598	Magnesium transport protein CorA
TFKS16_RS04070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TFKS16_RS04080	COG4974	Belongs to the 'phage' integrase family
TFKS16_RS04110	COG3250	beta-galactosidase activity
TFKS16_RS04115	COG3956	TIGRFAM MazG family protein
TFKS16_RS04140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TFKS16_RS04145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TFKS16_RS04150	COG0284	orotidine-5'-phosphate decarboxylase activity
TFKS16_RS04160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TFKS16_RS04165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TFKS16_RS04165	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TFKS16_RS04170	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TFKS16_RS04180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TFKS16_RS04190	COG0813	purine-nucleoside phosphorylase activity
TFKS16_RS04195	COG1012	belongs to the aldehyde dehydrogenase family
TFKS16_RS04250	COG0826	peptidase U32
TFKS16_RS04265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TFKS16_RS04270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TFKS16_RS04280	COG0280	phosphate acetyltransferase
TFKS16_RS04285	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TFKS16_RS04295	COG4771	TonB-dependent receptor
TFKS16_RS04300	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TFKS16_RS04305	COG1162	GTPase activity
TFKS16_RS04310	COG0233	cytoplasmic translational termination
TFKS16_RS04345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TFKS16_RS04380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TFKS16_RS04395	COG2096	Adenosyltransferase
TFKS16_RS04410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TFKS16_RS04445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TFKS16_RS04450	COG1028	Short-chain dehydrogenase reductase Sdr
TFKS16_RS04460	COG5434	Belongs to the glycosyl hydrolase 28 family
TFKS16_RS04465	COG2205	protein histidine kinase activity
TFKS16_RS04465	COG3292	Two component regulator propeller
TFKS16_RS04465	COG0745	RESPONSE REGULATOR receiver
TFKS16_RS04470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TFKS16_RS04490	COG4206	TonB-dependent receptor
TFKS16_RS04490	COG1629	transport
TFKS16_RS04575	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TFKS16_RS04575	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TFKS16_RS04590	COG0423	glycine-tRNA ligase activity
TFKS16_RS04605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TFKS16_RS04620	COG2197	response regulator
TFKS16_RS04635	COG1629	transport
TFKS16_RS04635	COG4206	TonB-dependent receptor
TFKS16_RS04655	COG4771	TonB-dependent receptor
TFKS16_RS04685	COG0702	epimerase
TFKS16_RS04690	COG4771	TonB-dependent receptor
TFKS16_RS04695	COG2706	6-phosphogluconolactonase activity
TFKS16_RS04720	COG0151	Belongs to the GarS family
TFKS16_RS04725	COG2095	MarC family integral membrane protein
TFKS16_RS04735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS04735	COG5549	protein import
TFKS16_RS04750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS04750	COG5549	protein import
TFKS16_RS04760	COG5549	protein import
TFKS16_RS04760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS04770	COG0714	Associated with various cellular activities
TFKS16_RS04805	COG0205	6-phosphofructokinase activity
TFKS16_RS04810	COG1904	glucuronate isomerase
TFKS16_RS04825	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TFKS16_RS04835	COG3119	arylsulfatase activity
TFKS16_RS04840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TFKS16_RS04845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TFKS16_RS04865	COG2076	Multidrug Resistance protein
TFKS16_RS04875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TFKS16_RS04880	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TFKS16_RS04900	COG2204	response regulator
TFKS16_RS04910	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TFKS16_RS04940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TFKS16_RS04945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TFKS16_RS04950	COG0509	glycine decarboxylation via glycine cleavage system
TFKS16_RS04960	COG1234	tRNA 3'-trailer cleavage
TFKS16_RS04970	COG5549	protein import
TFKS16_RS04970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS04975	COG1490	D-aminoacyl-tRNA deacylase activity
TFKS16_RS04980	COG0322	excinuclease ABC activity
TFKS16_RS04985	COG0445	tRNA wobble uridine modification
TFKS16_RS04995	COG0737	Belongs to the 5'-nucleotidase family
TFKS16_RS05000	COG0205	6-phosphofructokinase activity
TFKS16_RS05010	COG0571	ribonuclease III activity
TFKS16_RS05015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TFKS16_RS05020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TFKS16_RS05025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TFKS16_RS05065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TFKS16_RS05070	COG0793	Belongs to the peptidase S41A family
TFKS16_RS05070	COG3409	Peptidoglycan-binding domain 1 protein
TFKS16_RS05080	COG0673	inositol 2-dehydrogenase activity
TFKS16_RS05090	COG2244	polysaccharide biosynthetic process
TFKS16_RS05095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TFKS16_RS05100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TFKS16_RS05110	COG1028	Short-chain dehydrogenase reductase Sdr
TFKS16_RS05135	COG2089	acid synthase
TFKS16_RS05145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TFKS16_RS05150	COG1083	cytidylyl-transferase
TFKS16_RS05160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TFKS16_RS05185	COG0367	asparagine synthase
TFKS16_RS05195	COG3177	Filamentation induced by cAMP protein fic
TFKS16_RS05200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TFKS16_RS05210	COG0438	transferase activity, transferring glycosyl groups
TFKS16_RS05220	COG0438	transferase activity, transferring glycosyl groups
TFKS16_RS05235	COG1185	polyribonucleotide nucleotidyltransferase activity
TFKS16_RS05240	COG2195	Cleaves the N-terminal amino acid of tripeptides
TFKS16_RS05250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TFKS16_RS05255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TFKS16_RS05255	COG0517	IMP dehydrogenase activity
TFKS16_RS05265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TFKS16_RS05290	COG2814	Major facilitator Superfamily
TFKS16_RS05295	COG1233	COG1233 Phytoene dehydrogenase and related
TFKS16_RS05300	COG1629	transport
TFKS16_RS05300	COG4206	TonB-dependent receptor
TFKS16_RS05340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TFKS16_RS05340	COG0731	radical SAM domain protein
TFKS16_RS05355	COG4948	Mandelate Racemase Muconate Lactonizing
TFKS16_RS05375	COG0116	Belongs to the methyltransferase superfamily
TFKS16_RS05380	COG0823	Involved in the tonB-independent uptake of proteins
TFKS16_RS05380	COG1506	peptidase
TFKS16_RS05400	COG0142	geranyltranstransferase activity
TFKS16_RS05405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TFKS16_RS05405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TFKS16_RS05410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TFKS16_RS05415	COG2233	PERMEase
TFKS16_RS05420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TFKS16_RS05425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TFKS16_RS05440	COG1703	isobutyryl-CoA mutase activity
TFKS16_RS05445	COG1940	carbohydrate kinase activity
TFKS16_RS05455	COG0420	3'-5' exonuclease activity
TFKS16_RS05480	COG0702	epimerase
TFKS16_RS05485	COG1629	transport
TFKS16_RS05505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TFKS16_RS05520	COG0561	phosphatase activity
TFKS16_RS05525	COG4771	TonB-dependent receptor
TFKS16_RS05540	COG0528	UMP kinase activity
TFKS16_RS05545	COG0346	lactoylglutathione lyase activity
TFKS16_RS05550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TFKS16_RS05560	COG0511	ligase activity, forming carbon-carbon bonds
TFKS16_RS05565	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TFKS16_RS05570	COG1522	sequence-specific DNA binding
TFKS16_RS05590	COG0811	peptide transport
TFKS16_RS05600	COG0084	hydrolase, TatD family'
TFKS16_RS05620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TFKS16_RS05625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TFKS16_RS05630	COG1280	lysine exporter protein (LysE YggA)
TFKS16_RS05635	COG1022	Amp-dependent synthetase and ligase
TFKS16_RS05650	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TFKS16_RS05655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TFKS16_RS05660	COG0495	leucyl-tRNA aminoacylation
TFKS16_RS05670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TFKS16_RS05675	COG2715	membrane protein required for spore maturation
TFKS16_RS05680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TFKS16_RS05690	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TFKS16_RS05735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TFKS16_RS05735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TFKS16_RS05745	COG0802	atpase or kinase
TFKS16_RS05750	COG2204	response regulator
TFKS16_RS05765	COG1595	DNA-templated transcription, initiation
TFKS16_RS05795	COG1373	ATPase (AAA superfamily
TFKS16_RS05800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TFKS16_RS05820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TFKS16_RS05825	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TFKS16_RS05850	COG0745	RESPONSE REGULATOR receiver
TFKS16_RS05955	COG0540	Belongs to the ATCase OTCase family
TFKS16_RS05960	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TFKS16_RS05980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TFKS16_RS05985	COG1546	Belongs to the CinA family
TFKS16_RS05985	COG1058	Belongs to the CinA family
TFKS16_RS05990	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TFKS16_RS05995	COG0826	peptidase U32
TFKS16_RS06000	COG1410	methionine synthase
TFKS16_RS06000	COG0646	methionine synthase
TFKS16_RS06005	COG0475	glutathione-regulated potassium exporter activity
TFKS16_RS06045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TFKS16_RS06075	COG0066	3-isopropylmalate dehydratase activity
TFKS16_RS06085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TFKS16_RS06090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TFKS16_RS06100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TFKS16_RS06105	COG1482	cell wall glycoprotein biosynthetic process
TFKS16_RS06160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TFKS16_RS06160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TFKS16_RS06165	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TFKS16_RS06170	COG2194	sulfuric ester hydrolase activity
TFKS16_RS06175	COG0758	DNA mediated transformation
TFKS16_RS06215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TFKS16_RS06230	COG0733	neurotransmitter:sodium symporter activity
TFKS16_RS06235	COG1136	(ABC) transporter
TFKS16_RS06240	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
TFKS16_RS06265	COG2996	Protein conserved in bacteria
TFKS16_RS06280	COG2986	histidine ammonia-lyase
TFKS16_RS06285	COG3404	Formiminotransferase-cyclodeaminase
TFKS16_RS06295	COG1228	amidohydrolase
TFKS16_RS06315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TFKS16_RS06325	COG3119	arylsulfatase activity
TFKS16_RS06335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TFKS16_RS06345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TFKS16_RS06350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TFKS16_RS06355	COG0739	heme binding
TFKS16_RS06375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TFKS16_RS06380	COG3942	CHAP domain
TFKS16_RS06380	COG1388	LysM domain
TFKS16_RS06390	COG1475	DNA binding
TFKS16_RS06395	COG1192	Involved in chromosome partitioning
TFKS16_RS06400	COG0793	Belongs to the peptidase S41A family
TFKS16_RS06430	COG4206	TonB-dependent receptor
TFKS16_RS06450	COG4152	abc transporter atp-binding protein
TFKS16_RS06465	COG2986	histidine ammonia-lyase
TFKS16_RS06475	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TFKS16_RS06525	COG0366	Alpha amylase catalytic
TFKS16_RS06530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TFKS16_RS06540	COG0482	sulfurtransferase activity
TFKS16_RS06555	COG4771	TonB-dependent receptor
TFKS16_RS06585	COG1943	Transposase
TFKS16_RS06615	COG0428	transporter
TFKS16_RS06625	COG2226	methyltransferase
TFKS16_RS06630	COG2226	methyltransferase
TFKS16_RS06635	COG2226	methyltransferase
TFKS16_RS06645	COG2226	methyltransferase
TFKS16_RS06665	COG1132	(ABC) transporter
TFKS16_RS06675	COG1132	(ABC) transporter
TFKS16_RS06680	COG2066	Belongs to the glutaminase family
TFKS16_RS06700	COG0196	riboflavin kinase activity
TFKS16_RS06725	COG5492	domain, Protein
TFKS16_RS06730	COG0641	radical SAM
TFKS16_RS06740	COG1053	succinate dehydrogenase
TFKS16_RS06750	COG0018	arginyl-trna synthetase
TFKS16_RS06760	COG0525	valine-tRNA ligase activity
TFKS16_RS06790	COG1242	4 iron, 4 sulfur cluster binding
TFKS16_RS06800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TFKS16_RS06825	COG0436	Aminotransferase
TFKS16_RS06830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TFKS16_RS06830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TFKS16_RS06845	COG0779	Required for maturation of 30S ribosomal subunits
TFKS16_RS06850	COG2251	uridine kinase activity
TFKS16_RS06850	COG0195	Participates in both transcription termination and antitermination
TFKS16_RS06855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TFKS16_RS06865	COG0719	Fe-S assembly protein
TFKS16_RS06870	COG0396	ATPase activity
TFKS16_RS06875	COG0719	Fe-S assembly protein
TFKS16_RS06895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TFKS16_RS06900	COG0436	Aminotransferase
TFKS16_RS06925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TFKS16_RS06935	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TFKS16_RS06940	COG2166	iron-sulfur cluster assembly
TFKS16_RS06950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TFKS16_RS06955	COG0187	DNA topoisomerase II activity
TFKS16_RS06990	COG1216	Glycosyl transferase, family 2
TFKS16_RS06990	COG0463	Glycosyl transferase, family 2
TFKS16_RS07035	COG0268	Binds directly to 16S ribosomal RNA
TFKS16_RS07050	COG1629	transport
TFKS16_RS07050	COG4206	TonB-dependent receptor
TFKS16_RS07060	COG4771	TonB-dependent receptor
TFKS16_RS07070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TFKS16_RS07080	COG3118	belongs to the thioredoxin family
TFKS16_RS07110	COG0228	four-way junction DNA binding
TFKS16_RS07125	COG0514	ATP-dependent DNA helicase (RecQ)
TFKS16_RS07130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TFKS16_RS07130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TFKS16_RS07140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TFKS16_RS07150	COG0542	response to heat
TFKS16_RS07155	COG1253	flavin adenine dinucleotide binding
TFKS16_RS07160	COG1760	l-serine dehydratase
TFKS16_RS07165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TFKS16_RS07170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TFKS16_RS07175	COG0612	Peptidase, M16
TFKS16_RS07205	COG1940	carbohydrate kinase activity
TFKS16_RS07250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TFKS16_RS07255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TFKS16_RS07255	COG0674	pyruvate-flavodoxin oxidoreductase activity
TFKS16_RS07260	COG1013	pyruvate-flavodoxin oxidoreductase activity
TFKS16_RS07265	COG2177	Part of the ABC transporter FtsEX involved in
TFKS16_RS07275	COG1968	undecaprenyl-diphosphatase activity
TFKS16_RS07280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TFKS16_RS07285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TFKS16_RS07290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TFKS16_RS07335	COG1595	DNA-templated transcription, initiation
TFKS16_RS07350	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TFKS16_RS07355	COG1151	hydroxylamine reductase activity
TFKS16_RS07360	COG1217	gtp-binding protein TYPA
TFKS16_RS07365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TFKS16_RS07370	COG1509	lysine 2,3-aminomutase activity
TFKS16_RS07385	COG1271	oxidase subunit
TFKS16_RS07395	COG1595	DNA-templated transcription, initiation
TFKS16_RS07405	COG1629	transport
TFKS16_RS07415	COG0673	inositol 2-dehydrogenase activity
TFKS16_RS07430	COG0612	Peptidase, M16
TFKS16_RS07435	COG0038	chloride channel
TFKS16_RS07440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TFKS16_RS07445	COG0009	L-threonylcarbamoyladenylate synthase
TFKS16_RS07455	COG0363	glucosamine-6-phosphate deaminase activity
TFKS16_RS07465	COG0426	domain, Protein
TFKS16_RS07470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TFKS16_RS07475	COG0673	inositol 2-dehydrogenase activity
TFKS16_RS07485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TFKS16_RS07490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TFKS16_RS07495	COG0137	argininosuccinate synthase activity
TFKS16_RS07505	COG1438	arginine binding
TFKS16_RS07515	COG2211	Major facilitator Superfamily
TFKS16_RS07520	COG1032	radical SAM domain protein
TFKS16_RS07535	COG1131	(ABC) transporter
TFKS16_RS07550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TFKS16_RS07555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TFKS16_RS07560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TFKS16_RS07565	COG0742	ribosomal rna small subunit methyltransferase
TFKS16_RS07590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TFKS16_RS07600	COG1011	Hydrolase
TFKS16_RS07605	COG1492	cobalamin metabolic process
TFKS16_RS07610	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TFKS16_RS07615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TFKS16_RS07620	COG0251	oxidation-reduction process
TFKS16_RS07630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TFKS16_RS07635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TFKS16_RS07675	COG0336	Belongs to the RNA methyltransferase TrmD family
TFKS16_RS07680	COG0072	phenylalanine-tRNA ligase activity
TFKS16_RS07680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TFKS16_RS07685	COG0217	transcriptional regulatory protein
TFKS16_RS07710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TFKS16_RS07715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TFKS16_RS07720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TFKS16_RS07725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TFKS16_RS07730	COG0791	NLP P60 protein
TFKS16_RS07735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TFKS16_RS07740	COG1408	metallophosphoesterase
TFKS16_RS07760	COG4139	cobalamin transport
TFKS16_RS07780	COG0632	four-way junction helicase activity
TFKS16_RS07790	COG1074	ATP-dependent DNA helicase activity
TFKS16_RS07795	COG0688	phosphatidylethanolamine metabolic process
TFKS16_RS07800	COG1183	phosphatidylcholine synthase activity
TFKS16_RS07810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TFKS16_RS07850	COG0737	Belongs to the 5'-nucleotidase family
TFKS16_RS07885	COG2205	protein histidine kinase activity
TFKS16_RS07885	COG3292	Two component regulator propeller
TFKS16_RS07885	COG0745	RESPONSE REGULATOR receiver
TFKS16_RS07890	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TFKS16_RS07895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TFKS16_RS07910	COG1381	Involved in DNA repair and RecF pathway recombination
TFKS16_RS07920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TFKS16_RS07930	COG2843	Capsule synthesis protein
TFKS16_RS07935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TFKS16_RS07940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TFKS16_RS07945	COG4974	Belongs to the 'phage' integrase family
TFKS16_RS07965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TFKS16_RS07980	COG0250	Participates in transcription elongation, termination and antitermination
TFKS16_RS07985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TFKS16_RS07990	COG0081	regulation of translation
TFKS16_RS07995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TFKS16_RS08000	COG0222	ribosome binding
TFKS16_RS08005	COG0085	RNA polymerase activity
TFKS16_RS08010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TFKS16_RS08015	COG0433	COG0433 Predicted ATPase
TFKS16_RS08025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TFKS16_RS08030	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TFKS16_RS08035	COG4948	Mandelate Racemase Muconate Lactonizing
TFKS16_RS08145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TFKS16_RS08215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TFKS16_RS08280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TFKS16_RS08290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TFKS16_RS08290	COG0047	phosphoribosylformylglycinamidine synthase activity
TFKS16_RS08325	COG1629	transport
TFKS16_RS08330	COG0702	epimerase
TFKS16_RS08340	COG4221	oxidoreductase activity
TFKS16_RS08355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TFKS16_RS08360	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TFKS16_RS08360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TFKS16_RS08365	COG1368	sulfuric ester hydrolase activity
TFKS16_RS08370	COG1047	Peptidyl-prolyl cis-trans
TFKS16_RS08375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TFKS16_RS08380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS08395	COG0750	zinc metalloprotease
TFKS16_RS08400	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TFKS16_RS08405	COG4942	peptidase
TFKS16_RS08410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TFKS16_RS08425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TFKS16_RS08430	COG2183	response to ionizing radiation
TFKS16_RS08450	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TFKS16_RS08465	COG0488	(ABC) transporter
TFKS16_RS08470	COG0516	GMP reductase activity
TFKS16_RS08475	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TFKS16_RS08475	COG1918	ferrous iron import across plasma membrane
TFKS16_RS08490	COG3275	phosphorelay sensor kinase activity
TFKS16_RS08495	COG3279	Response regulator of the LytR AlgR family
TFKS16_RS08555	COG0148	phosphopyruvate hydratase activity
TFKS16_RS08565	COG0716	FMN binding
TFKS16_RS08590	COG4771	TonB-dependent receptor
TFKS16_RS08595	COG4771	TonB-dependent receptor
TFKS16_RS08610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TFKS16_RS08615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TFKS16_RS08635	COG3876	Protein conserved in bacteria
TFKS16_RS08645	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TFKS16_RS08650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TFKS16_RS08655	COG0052	Belongs to the universal ribosomal protein uS2 family
TFKS16_RS08660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TFKS16_RS08705	COG1629	transport
TFKS16_RS08725	COG4651	solute:proton antiporter activity
TFKS16_RS08725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TFKS16_RS08735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TFKS16_RS08755	COG1418	mRNA catabolic process
TFKS16_RS08760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TFKS16_RS08765	COG0488	(ABC) transporter
TFKS16_RS08785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TFKS16_RS08815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TFKS16_RS08830	COG3876	Protein conserved in bacteria
TFKS16_RS08835	COG2871	sodium ion transport
TFKS16_RS08840	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TFKS16_RS08845	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TFKS16_RS08850	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TFKS16_RS08855	COG1805	sodium ion transport
TFKS16_RS08860	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TFKS16_RS08870	COG0739	heme binding
TFKS16_RS08875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TFKS16_RS08880	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TFKS16_RS08885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TFKS16_RS08890	COG0563	adenylate kinase activity
TFKS16_RS08900	COG3845	ABC transporter
TFKS16_RS08910	COG0346	lactoylglutathione lyase activity
TFKS16_RS08925	COG0463	Glycosyl transferase, family 2
TFKS16_RS08935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TFKS16_RS08940	COG4452	Inner membrane protein CreD
TFKS16_RS08965	COG0564	pseudouridine synthase activity
TFKS16_RS08975	COG1028	Short-chain dehydrogenase reductase Sdr
TFKS16_RS08980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TFKS16_RS08985	COG1309	transcriptional regulator
TFKS16_RS09010	COG1472	Belongs to the glycosyl hydrolase 3 family
TFKS16_RS09015	COG2885	chlorophyll binding
TFKS16_RS09025	COG0542	response to heat
TFKS16_RS09040	COG3292	Two component regulator propeller
TFKS16_RS09040	COG2205	protein histidine kinase activity
TFKS16_RS09040	COG0745	RESPONSE REGULATOR receiver
TFKS16_RS09070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TFKS16_RS09080	COG2271	Major facilitator Superfamily
TFKS16_RS09085	COG4206	TonB-dependent receptor
TFKS16_RS09085	COG1629	transport
TFKS16_RS09090	COG0702	epimerase
TFKS16_RS09100	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TFKS16_RS09130	COG4822	anaerobic cobalamin biosynthetic process
TFKS16_RS09145	COG4771	TonB-dependent receptor
TFKS16_RS09150	COG1477	protein flavinylation
TFKS16_RS09165	COG1480	7TM receptor with intracellular HD hydrolase
TFKS16_RS09320	COG4383	Mu-like prophage protein gp29
TFKS16_RS09340	COG0740	serine-type endopeptidase activity
TFKS16_RS09475	COG0641	radical SAM
TFKS16_RS09535	COG1072	(Pantothenic acid kinase))
TFKS16_RS09555	COG1131	(ABC) transporter
TFKS16_RS09560	COG1131	(ABC) transporter
TFKS16_RS09565	COG0842	Transport permease protein
TFKS16_RS09590	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TFKS16_RS09595	COG1629	transport
TFKS16_RS09595	COG4206	TonB-dependent receptor
TFKS16_RS09600	COG1082	Xylose isomerase domain protein TIM barrel
TFKS16_RS09610	COG0343	queuine tRNA-ribosyltransferase activity
TFKS16_RS09620	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TFKS16_RS09630	COG1773	rubredoxin
TFKS16_RS09635	COG0583	DNA-binding transcription factor activity
TFKS16_RS09645	COG0668	transmembrane transport
TFKS16_RS09650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TFKS16_RS09660	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
TFKS16_RS09665	COG4771	TonB-dependent receptor
TFKS16_RS09675	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TFKS16_RS09680	COG4677	pectinesterase activity
TFKS16_RS09685	COG3119	arylsulfatase activity
TFKS16_RS09700	COG1028	Short-chain dehydrogenase reductase Sdr
TFKS16_RS09710	COG2271	Major facilitator Superfamily
TFKS16_RS09730	COG0577	efflux transmembrane transporter activity
TFKS16_RS09815	COG1570	exodeoxyribonuclease VII activity
TFKS16_RS09825	COG2502	aspartate--ammonia ligase
TFKS16_RS09835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TFKS16_RS09835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TFKS16_RS09840	COG1752	Esterase of the alpha-beta hydrolase superfamily
TFKS16_RS09850	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TFKS16_RS09905	COG3177	Filamentation induced by cAMP protein fic
TFKS16_RS09920	COG1353	crispr-associated protein
TFKS16_RS09930	COG1337	RAMP superfamily
TFKS16_RS09955	COG1518	maintenance of DNA repeat elements
TFKS16_RS09960	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TFKS16_RS09990	COG1528	Iron-storage protein
TFKS16_RS09995	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TFKS16_RS10010	COG0776	regulation of translation
TFKS16_RS10015	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TFKS16_RS10025	COG1640	4-alpha-glucanotransferase
TFKS16_RS10045	COG4589	Belongs to the CDS family
TFKS16_RS10050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TFKS16_RS10055	COG0799	negative regulation of ribosome biogenesis
TFKS16_RS10085	COG1629	transport
TFKS16_RS10085	COG4206	TonB-dependent receptor
TFKS16_RS10105	COG0285	dihydrofolate synthase activity
TFKS16_RS10110	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TFKS16_RS10120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TFKS16_RS10185	COG3177	Filamentation induced by cAMP protein fic
TFKS16_RS10215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TFKS16_RS10235	COG4974	Belongs to the 'phage' integrase family
TFKS16_RS10265	COG0497	DNA recombination
TFKS16_RS10270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TFKS16_RS10275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TFKS16_RS10280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TFKS16_RS10285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TFKS16_RS10290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TFKS16_RS10300	COG2195	Cleaves the N-terminal amino acid of tripeptides
TFKS16_RS10315	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TFKS16_RS10320	COG1979	alcohol dehydrogenase
TFKS16_RS10335	COG3250	beta-galactosidase activity
TFKS16_RS10340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TFKS16_RS10355	COG0470	DNA polymerase III
TFKS16_RS10360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TFKS16_RS10370	COG0534	Mate efflux family protein
TFKS16_RS10375	COG4771	TonB-dependent receptor
TFKS16_RS10415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TFKS16_RS10420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TFKS16_RS10425	COG1748	Saccharopine dehydrogenase
TFKS16_RS10440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TFKS16_RS10445	COG1215	transferase activity, transferring glycosyl groups
TFKS16_RS10480	COG3209	COG3209 Rhs family protein
TFKS16_RS10490	COG3209	COG3209 Rhs family protein
TFKS16_RS10500	COG3209	COG3209 Rhs family protein
TFKS16_RS10510	COG3209	COG3209 Rhs family protein
TFKS16_RS10605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TFKS16_RS10610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TFKS16_RS10620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TFKS16_RS10640	COG0358	DNA primase activity
TFKS16_RS10690	COG3344	reverse transcriptase
TFKS16_RS10765	COG1944	ATP diphosphatase activity
TFKS16_RS10775	COG1944	ATP diphosphatase activity
TFKS16_RS10780	COG0641	radical SAM
TFKS16_RS10790	COG0156	8-amino-7-oxononanoate synthase activity
TFKS16_RS10815	COG3344	reverse transcriptase
TFKS16_RS10850	COG0582	viral genome integration into host DNA
TFKS16_RS10875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TFKS16_RS10890	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TFKS16_RS10895	COG4974	Belongs to the 'phage' integrase family
TFKS16_RS10920	COG4206	TonB-dependent receptor
TFKS16_RS10920	COG1629	transport
TFKS16_RS10950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TFKS16_RS10960	COG0739	heme binding
TFKS16_RS10975	COG0149	triose-phosphate isomerase activity
TFKS16_RS10985	COG0302	gtp cyclohydrolase
TFKS16_RS10990	COG0009	L-threonylcarbamoyladenylate synthase
TFKS16_RS11005	COG4690	dipeptidase activity
TFKS16_RS11025	COG0545	Peptidyl-prolyl cis-trans isomerase
TFKS16_RS11030	COG0545	Peptidyl-prolyl cis-trans isomerase
TFKS16_RS11070	COG1629	transport
TFKS16_RS11070	COG4206	TonB-dependent receptor
TFKS16_RS11090	COG0823	Involved in the tonB-independent uptake of proteins
TFKS16_RS11100	COG0463	Glycosyl transferase, family 2
TFKS16_RS11105	COG1649	PFAM Uncharacterised BCR, COG1649
TFKS16_RS11110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TFKS16_RS11120	COG1388	LysM domain
TFKS16_RS11120	COG0860	N-Acetylmuramoyl-L-alanine amidase
TFKS16_RS11130	COG0741	lytic transglycosylase activity
TFKS16_RS11130	COG1388	LysM domain
TFKS16_RS11135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TFKS16_RS11145	COG1739	Uncharacterized protein family UPF0029
TFKS16_RS11155	COG0006	proline dipeptidase activity
TFKS16_RS11160	COG1785	Belongs to the alkaline phosphatase family
TFKS16_RS11175	COG5549	protein import
TFKS16_RS11175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS11190	COG5549	protein import
TFKS16_RS11190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS11195	COG5549	protein import
TFKS16_RS11195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS11210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS11210	COG5549	protein import
TFKS16_RS11215	COG4935	Belongs to the peptidase S8 family
TFKS16_RS11215	COG1404	Belongs to the peptidase S8 family
TFKS16_RS11230	COG5549	protein import
TFKS16_RS11230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS11235	COG5549	protein import
TFKS16_RS11235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS11245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS11245	COG5549	protein import
TFKS16_RS11260	COG5549	protein import
TFKS16_RS11260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS11265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS11265	COG5549	protein import
TFKS16_RS11285	COG5549	protein import
TFKS16_RS11285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_RS11305	COG1649	PFAM Uncharacterised BCR, COG1649
TFKS16_RS11315	COG0492	ferredoxin-NADP+ reductase activity
TFKS16_RS11325	COG1674	ftsk spoiiie
TFKS16_RS11330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TFKS16_RS11335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TFKS16_RS11345	COG0037	tRNA processing
TFKS16_RS11365	COG2197	response regulator
TFKS16_RS11370	COG0569	domain protein
TFKS16_RS11370	COG2985	domain, Protein
TFKS16_RS11390	COG1620	l-lactate permease
TFKS16_RS11395	COG1556	Lactate utilization protein
TFKS16_RS11400	COG1139	Iron-sulfur cluster binding protein
TFKS16_RS11440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TFKS16_RS11445	COG0321	lipoyl(octanoyl) transferase activity
TFKS16_RS11455	COG1774	PSP1 C-terminal conserved region
TFKS16_RS11460	COG0156	8-amino-7-oxononanoate synthase activity
TFKS16_RS11465	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TFKS16_RS11475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TFKS16_RS11480	COG0402	S-adenosylhomocysteine deaminase activity
TFKS16_RS11525	COG4206	TonB-dependent receptor
TFKS16_RS11525	COG1629	transport
TFKS16_RS11530	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TFKS16_RS11540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TFKS16_RS11545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TFKS16_RS11545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TFKS16_RS11550	COG0488	(ABC) transporter
TFKS16_RS11560	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TFKS16_RS11565	COG0706	membrane insertase activity
TFKS16_RS11570	COG0504	CTP synthase activity
TFKS16_RS11575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TFKS16_RS11590	COG2878	Part of a membrane complex involved in electron transport
TFKS16_RS11590	COG1245	4Fe-4S binding domain
TFKS16_RS11595	COG4656	Part of a membrane complex involved in electron transport
TFKS16_RS11600	COG4658	electron transport chain
TFKS16_RS11605	COG4659	FMN binding
TFKS16_RS11610	COG4660	Part of a membrane complex involved in electron transport
TFKS16_RS11615	COG4657	Part of a membrane complex involved in electron transport
TFKS16_RS11645	COG2252	PERMEase
TFKS16_RS11665	COG3119	arylsulfatase activity
TFKS16_RS11675	COG2096	Adenosyltransferase
TFKS16_RS11695	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TFKS16_RS11720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TFKS16_RS11740	COG3104	oligopeptide transport
TFKS16_RS11765	COG1629	transport
TFKS16_RS11765	COG4206	TonB-dependent receptor
TFKS16_RS11790	COG2115	Belongs to the xylose isomerase family
TFKS16_RS11795	COG0477	Major facilitator Superfamily
TFKS16_RS11795	COG2814	Major facilitator Superfamily
TFKS16_RS11815	COG4206	TonB-dependent receptor
TFKS16_RS11815	COG1629	transport
TFKS16_RS11890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TFKS16_RS11895	COG1032	radical SAM domain protein
TFKS16_RS11900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TFKS16_RS11905	COG0513	Belongs to the DEAD box helicase family
TFKS16_RS11960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TFKS16_RS11965	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TFKS16_RS11970	COG1663	tetraacyldisaccharide 4'-kinase activity
TFKS16_RS11975	COG0616	signal peptide processing
TFKS16_RS11980	COG0534	Mate efflux family protein
TFKS16_RS11990	COG1505	serine-type exopeptidase activity
TFKS16_RS12000	COG3292	Two component regulator propeller
TFKS16_RS12000	COG2205	protein histidine kinase activity
TFKS16_RS12000	COG0745	RESPONSE REGULATOR receiver
TFKS16_RS12050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TFKS16_RS12050	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TFKS16_RS12055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TFKS16_RS12060	COG0357	Ribosomal RNA small subunit methyltransferase G
TFKS16_RS12070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TFKS16_RS12090	COG0671	phosphoesterase, PA-phosphatase related
TFKS16_RS12110	COG2304	oxidoreductase activity
TFKS16_RS12115	COG2304	oxidoreductase activity
TFKS16_RS12130	COG0714	Associated with various cellular activities
TFKS16_RS12140	COG0776	regulation of translation
TFKS16_RS12145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TFKS16_RS12150	COG0552	protein localization to endoplasmic reticulum
TFKS16_RS12195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TFKS16_RS12215	COG1530	ribonuclease E activity
TFKS16_RS12220	COG0776	regulation of translation
TFKS16_RS12230	COG0629	single-stranded DNA binding
TFKS16_RS12270	COG0702	epimerase
TFKS16_RS12275	COG1629	transport
TFKS16_RS12290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TFKS16_RS12295	COG0671	phosphoesterase, PA-phosphatase related
TFKS16_RS12315	COG0673	inositol 2-dehydrogenase activity
TFKS16_RS12320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TFKS16_RS12325	COG2195	Cleaves the N-terminal amino acid of tripeptides
TFKS16_RS12335	COG0463	Glycosyl transferase, family 2
TFKS16_RS12350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TFKS16_RS12360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TFKS16_RS12370	COG1611	Belongs to the LOG family
TFKS16_RS12375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TFKS16_RS12390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TFKS16_RS12410	COG3537	Alpha-1,2-mannosidase
TFKS16_RS12415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TFKS16_RS12420	COG2226	methyltransferase
TFKS16_RS12425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TFKS16_RS12440	COG0006	proline dipeptidase activity
TFKS16_RS12495	COG3250	beta-galactosidase activity
TFKS16_RS12505	COG0481	GTPase activity
TFKS16_RS12510	COG4771	TonB-dependent receptor
TFKS16_RS12515	COG0702	epimerase
TFKS16_RS12520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TFKS16_RS12525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TFKS16_RS12530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TFKS16_RS12530	COG0574	Belongs to the PEP-utilizing enzyme family
TFKS16_RS12575	COG1629	transport
TFKS16_RS12595	COG0156	8-amino-7-oxononanoate synthase activity
TFKS16_RS12620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TFKS16_RS12640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TFKS16_RS12665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TFKS16_RS12670	COG0489	protein tyrosine kinase activity
TFKS16_RS12680	COG0793	Belongs to the peptidase S41A family
TFKS16_RS12685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TFKS16_RS12715	COG2194	sulfuric ester hydrolase activity
TFKS16_RS12755	COG0300	oxidoreductase activity
TFKS16_RS12765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TFKS16_RS12775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TFKS16_RS12780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TFKS16_RS12805	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
TFKS16_RS12810	COG0653	protein targeting
TFKS16_RS12815	COG3292	Two component regulator propeller
TFKS16_RS12815	COG2205	protein histidine kinase activity
TFKS16_RS12815	COG0745	RESPONSE REGULATOR receiver
TFKS16_RS12825	COG0242	peptide deformylase activity
TFKS16_RS12830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TFKS16_RS12835	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TFKS16_RS12845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TFKS16_RS12850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TFKS16_RS12860	COG0436	Aminotransferase
TFKS16_RS12870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TFKS16_RS12880	COG1678	Uncharacterized ACR, COG1678
TFKS16_RS12885	COG2873	o-acetylhomoserine
TFKS16_RS12890	COG1668	transmembrane transport
TFKS16_RS12895	COG4152	abc transporter atp-binding protein
TFKS16_RS12900	COG0358	DNA primase activity
TFKS16_RS12915	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TFKS16_RS12950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TFKS16_RS12965	COG0823	Involved in the tonB-independent uptake of proteins
TFKS16_RS12965	COG1506	peptidase
TFKS16_RS12970	COG0424	maF-like protein
TFKS16_RS12975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TFKS16_RS12990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TFKS16_RS12995	COG0193	aminoacyl-tRNA hydrolase activity
TFKS16_RS13000	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TFKS16_RS13035	COG0681	Belongs to the peptidase S26 family
TFKS16_RS13040	COG1132	(ABC) transporter
TFKS16_RS13055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TFKS16_RS13070	COG1575	Belongs to the MenA family. Type 1 subfamily
TFKS16_RS13075	COG4771	TonB-dependent receptor
TFKS16_RS13105	COG0848	biopolymer transport protein
TFKS16_RS13110	COG0811	peptide transport
TFKS16_RS13115	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TFKS16_RS13120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TFKS16_RS13125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TFKS16_RS13160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TFKS16_RS13165	COG2268	Band 7 protein
TFKS16_RS13185	COG0490	domain, Protein
TFKS16_RS13185	COG2985	domain, Protein
TFKS16_RS13265	COG1295	ribonuclease BN
TFKS16_RS13270	COG0460	homoserine dehydrogenase
TFKS16_RS13270	COG0527	aspartate kinase activity
TFKS16_RS13275	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TFKS16_RS13285	COG0363	glucosamine-6-phosphate deaminase activity
TFKS16_RS13290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TFKS16_RS13325	COG2832	Protein of unknown function (DUF454)
TFKS16_RS13330	COG2234	aminopeptidase activity
TFKS16_RS13340	COG0778	Nitroreductase
TFKS16_RS13345	COG0318	PFAM AMP-dependent synthetase and ligase
TFKS16_RS13385	COG1309	transcriptional regulator
TFKS16_RS13435	COG1373	ATPase (AAA superfamily
TFKS16_RS13460	COG0731	radical SAM domain protein
TFKS16_RS13460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TFKS16_RS13590	COG4974	Belongs to the 'phage' integrase family
TFKS16_RS13630	COG3645	SOS response
TFKS16_RS13635	COG0693	protein deglycase activity
TFKS16_RS13650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TFKS16_RS13650	COG2207	Transcriptional regulator
TFKS16_RS13675	COG1373	ATPase (AAA superfamily
TFKS16_RS13715	COG1196	nuclear chromosome segregation
TFKS16_RS13770	COG0564	pseudouridine synthase activity
TFKS16_RS13775	COG1181	Belongs to the D-alanine--D-alanine ligase family
TFKS16_RS13785	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TFKS16_RS13790	COG0179	Fumarylacetoacetate (FAA) hydrolase
TFKS16_RS13805	COG0793	Belongs to the peptidase S41A family
TFKS16_RS13805	COG4946	Tricorn protease homolog
TFKS16_RS13810	COG3250	beta-galactosidase activity
TFKS16_RS13820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TFKS16_RS13845	COG0058	SHG alpha-glucan phosphorylase activity
TFKS16_RS13855	COG1028	Short-chain dehydrogenase reductase Sdr
TFKS16_RS13875	COG3022	response to hydroperoxide
TFKS16_RS13885	COG1629	transport
TFKS16_RS13890	COG0702	epimerase
TFKS16_RS13900	COG4771	TonB-dependent receptor
TFKS16_RS13925	COG0254	rRNA binding
TFKS16_RS13930	COG0191	fructose-bisphosphate aldolase activity
TFKS16_RS13935	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TFKS16_RS13955	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TFKS16_RS13985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TFKS16_RS14000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TFKS16_RS14005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TFKS16_RS14015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TFKS16_RS14020	COG0305	Participates in initiation and elongation during chromosome replication
TFKS16_RS14030	COG0488	(ABC) transporter
TFKS16_RS14035	COG0138	bifunctional purine biosynthesis protein purh
TFKS16_RS14060	COG0772	Belongs to the SEDS family
TFKS16_RS14065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TFKS16_RS14070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TFKS16_RS14075	COG0166	Belongs to the GPI family
TFKS16_RS14085	COG0360	Binds together with S18 to 16S ribosomal RNA
TFKS16_RS14090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TFKS16_RS14095	COG0359	binds to the 23S rRNA
TFKS16_RS14100	COG0860	N-Acetylmuramoyl-L-alanine amidase