locus-tag	class	description
HB776_RS00005	COG0583	DNA-binding transcription factor activity
HB776_RS00010	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS00015	COG3959	Transketolase, thiamine diphosphate binding domain
HB776_RS00020	COG3958	Transketolase
HB776_RS00025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_RS00075	COG0523	cobalamin synthesis protein
HB776_RS00080	COG0523	cobalamin synthesis protein
HB776_RS00110	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HB776_RS00270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB776_RS00305	COG4608	Belongs to the ABC transporter superfamily
HB776_RS00310	COG0444	Belongs to the ABC transporter superfamily
HB776_RS00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS00320	COG0601	transmembrane transport
HB776_RS00330	COG0523	cobalamin synthesis protein
HB776_RS00360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS00375	COG1045	serine acetyltransferase
HB776_RS00380	COG1464	Belongs to the NlpA lipoprotein family
HB776_RS00395	COG1116	anion transmembrane transporter activity
HB776_RS00400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS00405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS00420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS00425	COG0747	negative chemotaxis
HB776_RS00430	COG0601	transmembrane transport
HB776_RS00435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS00455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS00460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS00470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS00470	COG1116	anion transmembrane transporter activity
HB776_RS00495	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_RS00525	COG0438	transferase activity, transferring glycosyl groups
HB776_RS00540	COG3693	PFAM glycoside hydrolase, family 10
HB776_RS00575	COG0489	protein tyrosine kinase activity
HB776_RS00575	COG3206	protein involved in exopolysaccharide biosynthesis
HB776_RS00605	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HB776_RS00630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB776_RS00635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB776_RS00650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_RS00655	COG4172	Belongs to the ABC transporter superfamily
HB776_RS00660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS00665	COG0601	transmembrane transport
HB776_RS00670	COG0747	negative chemotaxis
HB776_RS00675	COG0753	catalase activity
HB776_RS00695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_RS00720	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_RS00770	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_RS00775	COG0028	Belongs to the TPP enzyme family
HB776_RS00810	COG0747	negative chemotaxis
HB776_RS00815	COG0601	transmembrane transport
HB776_RS00820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS00840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS00845	COG0601	transmembrane transport
HB776_RS00850	COG0747	negative chemotaxis
HB776_RS00855	COG2072	flavoprotein involved in K transport
HB776_RS00860	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS00865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB776_RS00870	COG1802	Transcriptional regulator
HB776_RS00900	COG0583	DNA-binding transcription factor activity
HB776_RS00920	COG1012	belongs to the aldehyde dehydrogenase family
HB776_RS00930	COG0667	Aldo Keto reductase
HB776_RS00935	COG1012	belongs to the aldehyde dehydrogenase family
HB776_RS00955	COG1802	Transcriptional regulator
HB776_RS00960	COG0444	Belongs to the ABC transporter superfamily
HB776_RS00965	COG4608	Belongs to the ABC transporter superfamily
HB776_RS00985	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS01020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB776_RS01030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HB776_RS01090	COG2201	protein-glutamate methylesterase activity
HB776_RS01100	COG0754	glutathionylspermidine amidase activity
HB776_RS01110	COG3766	membrane
HB776_RS01150	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB776_RS01205	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB776_RS01290	COG0494	nUDIX hydrolase
HB776_RS01300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HB776_RS01305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HB776_RS01340	COG3547	Transposase (IS116 IS110 IS902 family)
HB776_RS01380	COG0746	molybdenum cofactor guanylyltransferase activity
HB776_RS01385	COG0425	Belongs to the sulfur carrier protein TusA family
HB776_RS01390	COG2223	nitrite transmembrane transporter activity
HB776_RS01410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_RS01430	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HB776_RS01455	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HB776_RS01465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HB776_RS01470	COG0366	Alpha amylase catalytic
HB776_RS01475	COG0366	Alpha amylase catalytic
HB776_RS01480	COG1640	4-alpha-glucanotransferase
HB776_RS01495	COG3265	gluconokinase activity
HB776_RS01500	COG0363	glucosamine-6-phosphate deaminase activity
HB776_RS01505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HB776_RS01510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HB776_RS01515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HB776_RS01540	COG0535	radical SAM domain protein
HB776_RS01550	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HB776_RS01555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HB776_RS01580	COG0154	amidase activity
HB776_RS01585	COG0386	Belongs to the glutathione peroxidase family
HB776_RS01600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS01605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS01610	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_RS01615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HB776_RS01630	COG2267	carboxylic ester hydrolase activity
HB776_RS01655	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS01660	COG1024	Enoyl-CoA hydratase
HB776_RS01680	COG0410	ABC transporter
HB776_RS01685	COG1137	ATPase activity
HB776_RS01690	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_RS01695	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_RS01725	COG2207	Transcriptional regulator
HB776_RS01775	COG1024	Enoyl-CoA hydratase
HB776_RS01795	COG2814	Major facilitator Superfamily
HB776_RS01800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB776_RS01815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB776_RS01825	COG2203	Gaf domain
HB776_RS01825	COG3706	GGDEF domain
HB776_RS01825	COG4251	negative regulation of phosphorylation
HB776_RS01825	COG5001	Diguanylate cyclase
HB776_RS01840	COG2897	thiosulfate sulfurtransferase activity
HB776_RS01850	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_RS01855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB776_RS01870	COG4106	trans-aconitate 2-methyltransferase activity
HB776_RS01930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_RS01955	COG2204	response regulator
HB776_RS01960	COG2391	methyltransferase activity
HB776_RS01970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HB776_RS01980	COG2022	thiamine diphosphate biosynthetic process
HB776_RS02035	COG1388	LysM domain
HB776_RS02035	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_RS02040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS02050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS02060	COG1309	transcriptional regulator
HB776_RS02075	COG5265	(ABC) transporter
HB776_RS02095	COG3795	YCII-related domain
HB776_RS02100	COG4941	Belongs to the sigma-70 factor family
HB776_RS02105	COG3023	N-Acetylmuramoyl-L-alanine amidase
HB776_RS02125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB776_RS02135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB776_RS02140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HB776_RS02155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HB776_RS02165	COG0583	DNA-binding transcription factor activity
HB776_RS02170	COG2814	Major facilitator Superfamily
HB776_RS02175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB776_RS02180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HB776_RS02190	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB776_RS02195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HB776_RS02200	COG0849	cell division
HB776_RS02205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB776_RS02215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB776_RS02230	COG2814	Major facilitator Superfamily
HB776_RS02235	COG0006	proline dipeptidase activity
HB776_RS02235	COG0006	proline dipeptidase activity
HB776_RS02240	COG2264	protein methyltransferase activity
HB776_RS02245	COG1233	COG1233 Phytoene dehydrogenase and related
HB776_RS02265	COG0842	Transport permease protein
HB776_RS02270	COG1131	(ABC) transporter
HB776_RS02280	COG0210	DNA helicase
HB776_RS02285	COG5487	UPF0391 membrane protein
HB776_RS02295	COG0277	FAD linked oxidase domain protein
HB776_RS02300	COG2271	Major facilitator Superfamily
HB776_RS02320	COG0114	fumarate hydratase activity
HB776_RS02360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HB776_RS02390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HB776_RS02455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB776_RS02455	COG2010	Cytochrome c
HB776_RS02470	COG1294	oxidase, subunit
HB776_RS02500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS02520	COG4191	Histidine kinase
HB776_RS02540	COG4566	intracellular signal transduction
HB776_RS02545	COG0745	RESPONSE REGULATOR receiver
HB776_RS02560	COG5002	protein histidine kinase activity
HB776_RS02565	COG1309	transcriptional regulator
HB776_RS02570	COG1566	PFAM secretion protein HlyD family protein
HB776_RS02580	COG0656	L-ascorbic acid biosynthetic process
HB776_RS02585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB776_RS02590	COG4977	sequence-specific DNA binding
HB776_RS02620	COG1942	4-Oxalocrotonate Tautomerase
HB776_RS02625	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS02630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB776_RS02635	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HB776_RS02650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB776_RS02650	COG1017	nitric oxide dioxygenase activity
HB776_RS02655	COG2267	carboxylic ester hydrolase activity
HB776_RS02670	COG1024	Enoyl-CoA hydratase
HB776_RS02670	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_RS02690	COG0596	Alpha beta hydrolase
HB776_RS02700	COG1764	response to oxidative stress
HB776_RS02730	COG0330	HflC and HflK could
HB776_RS02735	COG0330	HflC and HflK could
HB776_RS02750	COG0560	Phosphoserine phosphatase
HB776_RS02755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HB776_RS02760	COG3549	Plasmid maintenance system killer
HB776_RS02765	COG3093	addiction module antidote protein HigA
HB776_RS02770	COG0028	Belongs to the TPP enzyme family
HB776_RS02775	COG0440	acetolactate synthase activity
HB776_RS02790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HB776_RS02805	COG0300	oxidoreductase activity
HB776_RS02810	COG2186	Transcriptional regulator
HB776_RS02830	COG1174	glycine betaine transport
HB776_RS02835	COG1125	glycine betaine transport
HB776_RS02835	COG0517	IMP dehydrogenase activity
HB776_RS02845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS02850	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HB776_RS02865	COG2326	polyphosphate kinase activity
HB776_RS02870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_RS02875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB776_RS02945	COG1024	Enoyl-CoA hydratase
HB776_RS02955	COG0463	Glycosyl transferase, family 2
HB776_RS02965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB776_RS02970	COG1408	metallophosphoesterase
HB776_RS02980	COG0277	FAD linked oxidase domain protein
HB776_RS02980	COG0247	lactate metabolic process
HB776_RS02985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB776_RS02990	COG1024	Enoyl-CoA hydratase
HB776_RS02995	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS03015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_RS03040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB776_RS03040	COG2755	lipolytic protein G-D-S-L family
HB776_RS03050	COG1696	Membrane protein involved in D-alanine export
HB776_RS03095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB776_RS03120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB776_RS03125	COG1216	Glycosyl transferase, family 2
HB776_RS03140	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HB776_RS03140	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HB776_RS03145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB776_RS03150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB776_RS03155	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HB776_RS03165	COG3959	Transketolase, thiamine diphosphate binding domain
HB776_RS03170	COG3958	Transketolase
HB776_RS03175	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB776_RS03195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB776_RS03200	COG2942	2-epimerase
HB776_RS03235	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_RS03240	COG1022	Amp-dependent synthetase and ligase
HB776_RS03260	COG0411	ABC transporter
HB776_RS03280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_RS03335	COG0410	ABC transporter
HB776_RS03340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HB776_RS03360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HB776_RS03375	COG0270	DNA (cytosine-5-)-methyltransferase activity
HB776_RS03395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HB776_RS03405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HB776_RS03410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HB776_RS03430	COG1132	(ABC) transporter
HB776_RS03435	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB776_RS03440	COG2207	Transcriptional regulator
HB776_RS03460	COG0859	PFAM glycosyl transferase family 9
HB776_RS03470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HB776_RS03470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HB776_RS03475	COG1086	Polysaccharide biosynthesis protein
HB776_RS03490	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HB776_RS03490	COG0662	Cupin 2, conserved barrel domain protein
HB776_RS03495	COG0673	inositol 2-dehydrogenase activity
HB776_RS03510	COG0728	peptidoglycan biosynthetic process
HB776_RS03580	COG1088	dTDP-glucose 4,6-dehydratase activity
HB776_RS03590	COG1045	serine acetyltransferase
HB776_RS03655	COG3944	biosynthesis protein
HB776_RS03690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB776_RS03730	COG1450	Type ii and iii secretion system protein
HB776_RS03745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HB776_RS03750	COG1459	type II secretion system
HB776_RS03790	COG2165	general secretion pathway protein
HB776_RS03830	COG3909	cytochrome
HB776_RS03850	COG2010	Cytochrome c
HB776_RS03920	COG3386	PFAM SMP-30 Gluconolaconase
HB776_RS03925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_RS03930	COG0129	dihydroxy-acid dehydratase activity
HB776_RS03940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB776_RS03955	COG1309	transcriptional regulator
HB776_RS03960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS03970	COG1116	anion transmembrane transporter activity
HB776_RS03980	COG0673	inositol 2-dehydrogenase activity
HB776_RS04000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_RS04005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB776_RS04015	COG1573	uracil-dna glycosylase
HB776_RS04035	COG0587	DNA-directed DNA polymerase activity
HB776_RS04060	COG4251	negative regulation of phosphorylation
HB776_RS04070	COG0427	acetyl-CoA hydrolase
HB776_RS04095	COG0492	ferredoxin-NADP+ reductase activity
HB776_RS04100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_RS04150	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HB776_RS04155	COG1703	isobutyryl-CoA mutase activity
HB776_RS04195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB776_RS04205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB776_RS04220	COG0433	COG0433 Predicted ATPase
HB776_RS04240	COG0235	Class ii aldolase
HB776_RS04245	COG4977	sequence-specific DNA binding
HB776_RS04290	COG4957	zinc ion binding
HB776_RS04300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HB776_RS04305	COG2166	iron-sulfur cluster assembly
HB776_RS04315	COG2205	protein histidine kinase activity
HB776_RS04375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HB776_RS04380	COG2983	Belongs to the UPF0260 family
HB776_RS04385	COG2814	Major facilitator Superfamily
HB776_RS04425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB776_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS04595	COG0625	glutathione transferase activity
HB776_RS04600	COG4235	cytochrome complex assembly
HB776_RS04605	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HB776_RS04610	COG1138	Cytochrome C-type biogenesis protein
HB776_RS04615	COG3088	subunit of a heme lyase
HB776_RS04620	COG1802	Transcriptional regulator
HB776_RS04645	COG0745	RESPONSE REGULATOR receiver
HB776_RS04675	COG2205	protein histidine kinase activity
HB776_RS04680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB776_RS04700	COG2205	protein histidine kinase activity
HB776_RS04700	COG2202	Pas domain
HB776_RS04705	COG3321	synthase
HB776_RS04705	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS04705	COG0604	alcohol dehydrogenase
HB776_RS04720	COG2080	2 iron, 2 sulfur cluster binding
HB776_RS04725	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HB776_RS04730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB776_RS04770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_RS04790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HB776_RS04805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS04820	COG1024	Enoyl-CoA hydratase
HB776_RS04825	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS04875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_RS04880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_RS04905	COG2205	protein histidine kinase activity
HB776_RS04905	COG2202	Pas domain
HB776_RS04910	COG2084	Dehydrogenase
HB776_RS04915	COG0489	protein tyrosine kinase activity
HB776_RS04920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HB776_RS04925	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HB776_RS04950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB776_RS04960	COG0546	phosphoglycolate phosphatase activity
HB776_RS04965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HB776_RS04985	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HB776_RS04990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HB776_RS05015	COG0215	cysteine-tRNA ligase activity
HB776_RS05035	COG5265	(ABC) transporter
HB776_RS05040	COG0688	phosphatidylethanolamine metabolic process
HB776_RS05045	COG1183	phosphatidylcholine synthase activity
HB776_RS05060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HB776_RS05070	COG3158	transport of potassium into the cell
HB776_RS05075	COG3158	transport of potassium into the cell
HB776_RS05085	COG0436	Aminotransferase
HB776_RS05090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HB776_RS05100	COG0604	alcohol dehydrogenase
HB776_RS05100	COG3321	synthase
HB776_RS05105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB776_RS05115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HB776_RS05120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB776_RS05135	COG1285	pathogenesis
HB776_RS05150	COG0583	DNA-binding transcription factor activity
HB776_RS05165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HB776_RS05185	COG1953	Uracil, thiamine, allantoin
HB776_RS05210	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS05215	COG0367	asparagine synthase
HB776_RS05220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HB776_RS05225	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HB776_RS05230	COG0840	transmembrane signaling receptor activity
HB776_RS05235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HB776_RS05250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB776_RS05255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_RS05265	COG4774	siderophore transport
HB776_RS05270	COG3128	pkhd-type hydroxylase
HB776_RS05280	COG0848	biopolymer transport protein
HB776_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS05300	COG0129	dihydroxy-acid dehydratase activity
HB776_RS05305	COG3842	ATPase activity
HB776_RS05325	COG0395	ABC-type sugar transport system, permease component
HB776_RS05330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_RS05335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB776_RS05340	COG0800	Aldolase
HB776_RS05345	COG0183	Belongs to the thiolase family
HB776_RS05350	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS05355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_RS05365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB776_RS05375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB776_RS05375	COG1042	CoA-binding domain protein
HB776_RS05375	COG0045	succinate-CoA ligase (ADP-forming) activity
HB776_RS05380	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB776_RS05395	COG0415	Belongs to the DNA photolyase family
HB776_RS05405	COG0450	alkyl hydroperoxide reductase
HB776_RS05435	COG4770	biotin carboxylase activity
HB776_RS05440	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HB776_RS05445	COG1254	Belongs to the acylphosphatase family
HB776_RS05450	COG0321	lipoyl(octanoyl) transferase activity
HB776_RS05575	COG3293	Transposase
HB776_RS05660	COG2239	Acts as a magnesium transporter
HB776_RS05685	COG0656	L-ascorbic acid biosynthetic process
HB776_RS05735	COG2030	dehydratase
HB776_RS05740	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS05760	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS05990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB776_RS06020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB776_RS06025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB776_RS06030	COG2271	Major facilitator Superfamily
HB776_RS06035	COG0183	Belongs to the thiolase family
HB776_RS06040	COG1024	Enoyl-CoA hydratase
HB776_RS06040	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_RS06055	COG1960	acyl-CoA dehydrogenase activity
HB776_RS06070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB776_RS06080	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS06085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB776_RS06085	COG0493	'glutamate synthase
HB776_RS06095	COG0488	(ABC) transporter
HB776_RS06100	COG1671	Belongs to the UPF0178 family
HB776_RS06130	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS06150	COG0416	fatty acid biosynthetic process
HB776_RS06155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB776_RS06160	COG0776	regulation of translation
HB776_RS06230	COG1612	heme a metabolic process
HB776_RS06235	COG0672	)-iron permease
HB776_RS06250	COG1024	Enoyl-CoA hydratase
HB776_RS06260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HB776_RS06265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HB776_RS06285	COG0628	permease
HB776_RS06295	COG0174	glutamine synthetase
HB776_RS06300	COG0347	Belongs to the P(II) protein family
HB776_RS06305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HB776_RS06305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB776_RS06320	COG0544	peptidyl-prolyl cis-trans isomerase activity
HB776_RS06325	COG0740	serine-type endopeptidase activity
HB776_RS06330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HB776_RS06355	COG3916	Acyl-homoserine-lactone synthase
HB776_RS06360	COG2197	response regulator
HB776_RS06370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_RS06375	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB776_RS06380	COG0776	regulation of translation
HB776_RS06405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB776_RS06415	COG0649	NAD binding
HB776_RS06430	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HB776_RS06440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HB776_RS06455	COG0713	ATP synthesis coupled electron transport
HB776_RS06470	COG1007	ATP synthesis coupled electron transport
HB776_RS06485	COG0346	lactoylglutathione lyase activity
HB776_RS06500	COG0442	prolyl-tRNA aminoacylation
HB776_RS06510	COG1136	(ABC) transporter
HB776_RS06525	COG0052	Belongs to the universal ribosomal protein uS2 family
HB776_RS06530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HB776_RS06535	COG0528	UMP kinase activity
HB776_RS06540	COG0233	cytoplasmic translational termination
HB776_RS06545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB776_RS06555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HB776_RS06560	COG0750	zinc metalloprotease
HB776_RS06565	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB776_RS06570	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB776_RS06575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HB776_RS06580	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB776_RS06590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB776_RS06595	COG0372	Belongs to the citrate synthase family
HB776_RS06600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB776_RS06605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB776_RS06615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB776_RS06620	COG0456	acetyltransferase
HB776_RS06625	COG1982	Orn Lys Arg decarboxylase major
HB776_RS06650	COG1011	Hydrolase
HB776_RS06660	COG2124	cytochrome p450
HB776_RS06690	COG0315	cyclic pyranopterin monophosphate synthase activity
HB776_RS06695	COG0134	indole-3-glycerol-phosphate synthase activity
HB776_RS06700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB776_RS06720	COG0149	triose-phosphate isomerase activity
HB776_RS06730	COG0504	CTP synthase activity
HB776_RS06770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HB776_RS06780	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HB776_RS06805	COG2020	methyltransferase activity
HB776_RS06830	COG0431	NADPH-dependent FMN reductase
HB776_RS06840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB776_RS06845	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB776_RS06845	COG0022	dehydrogenase e1 component
HB776_RS06855	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB776_RS06865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB776_RS06875	COG0129	dihydroxy-acid dehydratase activity
HB776_RS06880	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HB776_RS06910	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HB776_RS06915	COG0018	arginyl-trna synthetase
HB776_RS06925	COG1472	Belongs to the glycosyl hydrolase 3 family
HB776_RS06930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HB776_RS06935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HB776_RS06940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HB776_RS06945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HB776_RS06950	COG0805	protein transport
HB776_RS06960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HB776_RS06970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HB776_RS06980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB776_RS06990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HB776_RS07000	COG1862	Preprotein translocase
HB776_RS07005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB776_RS07030	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HB776_RS07075	COG0546	phosphoglycolate phosphatase activity
HB776_RS07090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB776_RS07105	COG0629	single-stranded DNA binding
HB776_RS07130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HB776_RS07135	COG1335	isochorismatase
HB776_RS07140	COG0583	DNA-binding transcription factor activity
HB776_RS07145	COG3158	transport of potassium into the cell
HB776_RS07180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HB776_RS07185	COG0343	queuine tRNA-ribosyltransferase activity
HB776_RS07210	COG0697	spore germination
HB776_RS07260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HB776_RS07270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB776_RS07290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB776_RS07325	COG0679	Auxin Efflux Carrier
HB776_RS07330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_RS07335	COG1183	phosphatidylcholine synthase activity
HB776_RS07340	COG1253	flavin adenine dinucleotide binding
HB776_RS07350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HB776_RS07355	COG3707	response regulator
HB776_RS07360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS07360	COG1116	anion transmembrane transporter activity
HB776_RS07365	COG0175	sulfate reduction
HB776_RS07380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB776_RS07400	COG1116	anion transmembrane transporter activity
HB776_RS07405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS07410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS07420	COG1960	acyl-CoA dehydrogenase activity
HB776_RS07425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS07435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB776_RS07440	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HB776_RS07445	COG1984	allophanate hydrolase subunit 2
HB776_RS07455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB776_RS07465	COG1522	sequence-specific DNA binding
HB776_RS07470	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HB776_RS07490	COG0154	amidase activity
HB776_RS07495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_RS07590	COG1686	Belongs to the peptidase S11 family
HB776_RS07595	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HB776_RS07605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB776_RS07610	COG0084	hydrolase, TatD family'
HB776_RS07615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HB776_RS07615	COG0321	lipoyl(octanoyl) transferase activity
HB776_RS07625	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS07630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HB776_RS07635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_RS07640	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS07680	COG4459	periplasmic nitrate reductase
HB776_RS07690	COG0243	molybdopterin cofactor binding
HB776_RS07700	COG3005	denitrification pathway
HB776_RS07735	COG0588	phosphoglycerate mutase activity
HB776_RS07755	COG0038	chloride channel
HB776_RS07765	COG1595	DNA-templated transcription, initiation
HB776_RS07805	COG0813	purine-nucleoside phosphorylase activity
HB776_RS07840	COG2059	Chromate
HB776_RS07915	COG0277	FAD linked oxidase domain protein
HB776_RS07920	COG2186	Transcriptional regulator
HB776_RS07925	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS07930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_RS07935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HB776_RS07940	COG3956	TIGRFAM MazG family protein
HB776_RS07950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB776_RS07955	COG1923	regulation of RNA biosynthetic process
HB776_RS07965	COG2204	response regulator
HB776_RS07970	COG5000	phosphorelay sensor kinase activity
HB776_RS07990	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HB776_RS07990	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HB776_RS08000	COG2867	negative regulation of translational initiation
HB776_RS08005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB776_RS08010	COG2094	Belongs to the DNA glycosylase MPG family
HB776_RS08015	COG0525	valine-tRNA ligase activity
HB776_RS08030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB776_RS08055	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_RS08060	COG0823	Involved in the tonB-independent uptake of proteins
HB776_RS08095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB776_RS08115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB776_RS08125	COG1126	abc transporter atp-binding protein
HB776_RS08130	COG0765	amino acid transport
HB776_RS08135	COG4597	amino acid ABC transporter
HB776_RS08140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB776_RS08145	COG0626	cystathionine gamma-synthase activity
HB776_RS08155	COG0463	Glycosyl transferase, family 2
HB776_RS08170	COG4953	penicillin-binding protein 1C
HB776_RS08175	COG2373	Large extracellular alpha-helical protein
HB776_RS08205	COG4191	Histidine kinase
HB776_RS08205	COG0784	Response regulator, receiver
HB776_RS08225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB776_RS08250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_RS08285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_RS08300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB776_RS08330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB776_RS08425	COG0625	glutathione transferase activity
HB776_RS08545	COG1509	lysine 2,3-aminomutase activity
HB776_RS08550	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HB776_RS08555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HB776_RS08565	COG0114	fumarate hydratase activity
HB776_RS08575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB776_RS08580	COG2188	Transcriptional regulator
HB776_RS08590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB776_RS08595	COG0546	phosphoglycolate phosphatase activity
HB776_RS08615	COG0436	Aminotransferase
HB776_RS08625	COG3243	poly(R)-hydroxyalkanoic acid synthase
HB776_RS08635	COG2066	Belongs to the glutaminase family
HB776_RS08645	COG0174	glutamine synthetase
HB776_RS08655	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HB776_RS08675	COG0586	Pfam SNARE associated Golgi protein
HB776_RS08695	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS08700	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS08705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_RS08735	COG3706	GGDEF domain
HB776_RS08745	COG0316	Belongs to the HesB IscA family
HB776_RS08755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB776_RS08760	COG0719	Fe-S assembly protein
HB776_RS08765	COG0396	ATPase activity
HB776_RS08780	COG1104	cysteine desulfurase activity
HB776_RS08785	COG2945	thiolester hydrolase activity
HB776_RS08795	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HB776_RS08800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB776_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS08850	COG2192	nodulation
HB776_RS08860	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_RS08885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HB776_RS08890	COG0860	N-Acetylmuramoyl-L-alanine amidase
HB776_RS08895	COG1530	ribonuclease E activity
HB776_RS08895	COG1530	ribonuclease E activity
HB776_RS08900	COG1301	dicarboxylic acid transport
HB776_RS08905	COG1268	BioY protein
HB776_RS08910	COG0436	Aminotransferase
HB776_RS08940	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HB776_RS08960	COG4993	Dehydrogenase
HB776_RS08980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HB776_RS08995	COG5002	protein histidine kinase activity
HB776_RS09000	COG0784	Response regulator, receiver
HB776_RS09005	COG3920	Histidine kinase
HB776_RS09035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HB776_RS09040	COG0471	metal ion transport
HB776_RS09045	COG1252	NADH dehydrogenase
HB776_RS09050	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HB776_RS09065	COG0657	acetylesterase activity
HB776_RS09080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_RS09085	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HB776_RS09115	COG2205	protein histidine kinase activity
HB776_RS09125	COG3038	cytochrome b561
HB776_RS09130	COG0697	spore germination
HB776_RS09135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB776_RS09145	COG3621	Patatin-like phospholipase
HB776_RS09210	COG1335	isochorismatase
HB776_RS09230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS09235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS09240	COG1116	anion transmembrane transporter activity
HB776_RS09265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS09270	COG1228	amidohydrolase
HB776_RS09275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HB776_RS09280	COG0154	amidase activity
HB776_RS09290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS09300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS09310	COG1053	succinate dehydrogenase
HB776_RS09325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB776_RS09330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS09335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS09350	COG1522	sequence-specific DNA binding
HB776_RS09355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS09360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS09365	COG1116	anion transmembrane transporter activity
HB776_RS09385	COG1396	sequence-specific DNA binding
HB776_RS09430	COG2897	thiosulfate sulfurtransferase activity
HB776_RS09470	COG0412	Dienelactone hydrolase
HB776_RS09485	COG1464	Belongs to the NlpA lipoprotein family
HB776_RS09490	COG4608	Belongs to the ABC transporter superfamily
HB776_RS09495	COG0444	Belongs to the ABC transporter superfamily
HB776_RS09500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS09505	COG0601	transmembrane transport
HB776_RS09510	COG0747	negative chemotaxis
HB776_RS09575	COG0183	Belongs to the thiolase family
HB776_RS09585	COG1960	acyl-CoA dehydrogenase activity
HB776_RS09595	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS09615	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS09630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_RS09640	COG1024	Enoyl-CoA hydratase
HB776_RS09660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_RS09675	COG1304	FMN binding
HB776_RS09740	COG2837	iron assimilation
HB776_RS09780	COG1309	transcriptional regulator
HB776_RS09790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HB776_RS09825	COG0625	glutathione transferase activity
HB776_RS09840	COG2207	Transcriptional regulator
HB776_RS09840	COG4753	response regulator
HB776_RS09860	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS09900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_RS09910	COG2814	Major facilitator Superfamily
HB776_RS09915	COG2814	Major facilitator Superfamily
HB776_RS09920	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS09925	COG0513	Belongs to the DEAD box helicase family
HB776_RS09930	COG1285	pathogenesis
HB776_RS10015	COG0386	Belongs to the glutathione peroxidase family
HB776_RS10035	COG0281	malic enzyme
HB776_RS10035	COG0280	phosphate acetyltransferase
HB776_RS10040	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HB776_RS10055	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HB776_RS10060	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HB776_RS10070	COG0248	Ppx GppA phosphatase
HB776_RS10075	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HB776_RS10090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HB776_RS10095	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB776_RS10105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_RS10115	COG1309	transcriptional regulator
HB776_RS10120	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HB776_RS10130	COG1278	Cold shock
HB776_RS10140	COG0861	Integral membrane protein TerC family
HB776_RS10145	COG0105	UTP biosynthetic process
HB776_RS10160	COG0488	(ABC) transporter
HB776_RS10175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HB776_RS10190	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HB776_RS10200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HB776_RS10205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB776_RS10240	COG1178	ABC-type Fe3 transport system permease component
HB776_RS10250	COG3842	ATPase activity
HB776_RS10265	COG0194	GDP metabolic process
HB776_RS10270	COG1561	YicC-like family, N-terminal region
HB776_RS10275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB776_RS10280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB776_RS10295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB776_RS10300	COG0360	Binds together with S18 to 16S ribosomal RNA
HB776_RS10305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HB776_RS10315	COG0359	binds to the 23S rRNA
HB776_RS10325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB776_RS10335	COG0305	Participates in initiation and elongation during chromosome replication
HB776_RS10340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB776_RS10380	COG1286	toxin biosynthetic process
HB776_RS10385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HB776_RS10390	COG0300	oxidoreductase activity
HB776_RS10435	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
HB776_RS10440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_RS10455	COG2020	methyltransferase activity
HB776_RS10480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HB776_RS10490	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS10540	COG0306	phosphate transporter
HB776_RS10545	COG1392	Phosphate transport regulator
HB776_RS10550	COG4214	carbohydrate transport
HB776_RS10555	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_RS10585	COG1393	Belongs to the ArsC family
HB776_RS10595	COG1846	Transcriptional regulator
HB776_RS10605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HB776_RS10615	COG1418	mRNA catabolic process
HB776_RS10625	COG0596	Alpha beta hydrolase
HB776_RS10635	COG0242	peptide deformylase activity
HB776_RS10665	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB776_RS10730	COG1049	propionate catabolic process, 2-methylcitrate cycle
HB776_RS10740	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS10750	COG0698	ribose 5-phosphate isomerase
HB776_RS10755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB776_RS10755	COG0519	Catalyzes the synthesis of GMP from XMP
HB776_RS10780	COG2130	NADP-dependent
HB776_RS10810	COG1309	transcriptional regulator
HB776_RS10815	COG0697	spore germination
HB776_RS10820	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HB776_RS10845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HB776_RS10850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HB776_RS10855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HB776_RS10865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB776_RS10865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB776_RS10870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HB776_RS10875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HB776_RS10910	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS10920	COG0113	porphobilinogen synthase activity
HB776_RS10950	COG1914	H( )-stimulated, divalent metal cation uptake system
HB776_RS10960	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HB776_RS10975	COG2814	Major facilitator Superfamily
HB776_RS10990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_RS10995	COG1253	flavin adenine dinucleotide binding
HB776_RS11015	COG1393	Belongs to the ArsC family
HB776_RS11020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HB776_RS11055	COG1381	Involved in DNA repair and RecF pathway recombination
HB776_RS11065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB776_RS11070	COG0571	ribonuclease III activity
HB776_RS11075	COG0681	Belongs to the peptidase S26 family
HB776_RS11080	COG0736	holo-[acyl-carrier-protein] synthase activity
HB776_RS11085	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HB776_RS11095	COG1758	RNA polymerase activity
HB776_RS11115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HB776_RS11120	COG1970	mechanosensitive ion channel activity
HB776_RS11125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_RS11130	COG0741	lytic transglycosylase activity
HB776_RS11150	COG1335	isochorismatase
HB776_RS11165	COG2207	Transcriptional regulator
HB776_RS11185	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB776_RS11195	COG3920	Histidine kinase
HB776_RS11200	COG0154	amidase activity
HB776_RS11210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB776_RS11235	COG0679	Auxin Efflux Carrier
HB776_RS11245	COG1960	acyl-CoA dehydrogenase activity
HB776_RS11255	COG1309	transcriptional regulator
HB776_RS11260	COG2814	Major facilitator Superfamily
HB776_RS11265	COG0540	Belongs to the ATCase OTCase family
HB776_RS11270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_RS11275	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HB776_RS11280	COG0789	Transcriptional regulator
HB776_RS11285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB776_RS11300	COG1733	regulation of RNA biosynthetic process
HB776_RS11305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB776_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS11325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB776_RS11330	COG0557	exoribonuclease II activity
HB776_RS11355	COG0583	DNA-binding transcription factor activity
HB776_RS11360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS11365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HB776_RS11380	COG0784	Response regulator, receiver
HB776_RS11390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB776_RS11400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_RS11435	COG0537	adenosine 5'-monophosphoramidase activity
HB776_RS11440	COG1720	tRNA m6t6A37 methyltransferase activity
HB776_RS11480	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB776_RS11495	COG1686	Belongs to the peptidase S11 family
HB776_RS11515	COG1192	Involved in chromosome partitioning
HB776_RS11520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HB776_RS11535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HB776_RS11565	COG2267	carboxylic ester hydrolase activity
HB776_RS11580	COG2860	membrane
HB776_RS11620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB776_RS11645	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB776_RS11665	COG0778	Nitroreductase
HB776_RS11675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB776_RS11680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB776_RS11685	COG1733	regulation of RNA biosynthetic process
HB776_RS11700	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS11705	COG0203	ribosomal protein L17
HB776_RS11710	COG0202	RNA polymerase activity
HB776_RS11715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HB776_RS11720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HB776_RS11725	COG0563	adenylate kinase activity
HB776_RS11730	COG0201	protein transport
HB776_RS11735	COG0200	Binds to the 23S rRNA
HB776_RS11740	COG1841	ribosomal large subunit assembly
HB776_RS11745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HB776_RS11750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HB776_RS11755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HB776_RS11760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HB776_RS11765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HB776_RS11770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HB776_RS11775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HB776_RS11780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HB776_RS11785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HB776_RS11790	COG0255	Belongs to the universal ribosomal protein uL29 family
HB776_RS11795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HB776_RS11800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HB776_RS11805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HB776_RS11810	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HB776_RS11815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HB776_RS11820	COG0089	rRNA binding
HB776_RS11825	COG0088	Forms part of the polypeptide exit tunnel
HB776_RS11830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HB776_RS11835	COG0051	transcription antitermination factor activity, RNA binding
HB776_RS11840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HB776_RS11845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HB776_RS11855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HB776_RS11860	COG0251	oxidation-reduction process
HB776_RS11870	COG1132	(ABC) transporter
HB776_RS11875	COG1231	oxidoreductase activity
HB776_RS11885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HB776_RS11890	COG0085	RNA polymerase activity
HB776_RS11895	COG0222	ribosome binding
HB776_RS11900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HB776_RS11935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB776_RS11940	COG0081	regulation of translation
HB776_RS11945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HB776_RS11955	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HB776_RS11975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HB776_RS12020	COG1960	acyl-CoA dehydrogenase activity
HB776_RS12060	COG1464	Belongs to the NlpA lipoprotein family
HB776_RS12065	COG2011	ABC-type metal ion transport system permease component
HB776_RS12070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB776_RS12075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS12080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS12095	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HB776_RS12105	COG2723	6-phospho-beta-galactosidase activity
HB776_RS12110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB776_RS12125	COG4149	molybdate abc transporter
HB776_RS12150	COG3706	GGDEF domain
HB776_RS12170	COG1063	alcohol dehydrogenase
HB776_RS12175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_RS12185	COG3842	ATPase activity
HB776_RS12190	COG1177	transmembrane transport
HB776_RS12195	COG1176	ABC-type spermidine putrescine transport system, permease component I
HB776_RS12210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_RS12225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_RS12255	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HB776_RS12275	COG3258	Cytochrome c
HB776_RS12280	COG2010	Cytochrome c
HB776_RS12295	COG0785	Cytochrome C biogenesis protein
HB776_RS12305	COG0640	Transcriptional regulator
HB776_RS12325	COG2391	methyltransferase activity
HB776_RS12340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB776_RS12435	COG0783	Belongs to the Dps family
HB776_RS12445	COG0596	Alpha beta hydrolase
HB776_RS12455	COG1275	C4-dicarboxylate transporter malic acid transport protein
HB776_RS12470	COG2207	Transcriptional regulator
HB776_RS12525	COG2149	membrane
HB776_RS12545	COG3258	Cytochrome c
HB776_RS12560	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS12620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB776_RS12650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB776_RS12655	COG0302	gtp cyclohydrolase
HB776_RS12675	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HB776_RS12690	COG2814	Major facilitator Superfamily
HB776_RS12695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HB776_RS12710	COG5001	Diguanylate cyclase
HB776_RS12720	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB776_RS12815	COG2197	response regulator
HB776_RS12830	COG2267	carboxylic ester hydrolase activity
HB776_RS12860	COG1349	DNA-binding transcription factor activity
HB776_RS12865	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HB776_RS12870	COG3395	kinase activity
HB776_RS12890	COG0477	Major facilitator Superfamily
HB776_RS12895	COG0251	oxidation-reduction process
HB776_RS12910	COG0747	negative chemotaxis
HB776_RS12915	COG0747	negative chemotaxis
HB776_RS12925	COG0601	transmembrane transport
HB776_RS12930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS12945	COG1473	amidohydrolase
HB776_RS12950	COG1024	Enoyl-CoA hydratase
HB776_RS12970	COG0625	glutathione transferase activity
HB776_RS12975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HB776_RS12985	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HB776_RS12990	COG1546	Belongs to the CinA family
HB776_RS12990	COG1058	Belongs to the CinA family
HB776_RS12995	COG2308	Evidence 4 Homologs of previously reported genes of
HB776_RS13020	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS13025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HB776_RS13040	COG5425	PFAM Usg family protein
HB776_RS13045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HB776_RS13050	COG0459	protein refolding
HB776_RS13055	COG0251	oxidation-reduction process
HB776_RS13060	COG0640	Transcriptional regulator
HB776_RS13065	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS13125	COG1959	2 iron, 2 sulfur cluster binding
HB776_RS13140	COG3186	Phenylalanine-4-hydroxylase
HB776_RS13150	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB776_RS13160	COG0463	Glycosyl transferase, family 2
HB776_RS13200	COG2068	MobA-Related Protein
HB776_RS13205	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HB776_RS13205	COG3608	succinylglutamate desuccinylase aspartoacylase
HB776_RS13240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB776_RS13250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB776_RS13310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB776_RS13315	COG0785	Cytochrome C biogenesis protein
HB776_RS13320	COG3191	aminopeptidase activity
HB776_RS13350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB776_RS13375	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HB776_RS13380	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HB776_RS13395	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HB776_RS13405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB776_RS13410	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HB776_RS13430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_RS13435	COG2197	response regulator
HB776_RS13445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB776_RS13460	COG0384	phenazine biosynthesis protein PhzF
HB776_RS13470	COG4829	muconolactone delta-isomerase
HB776_RS13490	COG0583	DNA-binding transcription factor activity
HB776_RS13500	COG2610	gluconate transmembrane transporter activity
HB776_RS13510	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS13515	COG0047	phosphoribosylformylglycinamidine synthase activity
HB776_RS13520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB776_RS13525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HB776_RS13535	COG4774	siderophore transport
HB776_RS13545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS13565	COG3708	Transcriptional regulator
HB776_RS13565	COG2207	Transcriptional regulator
HB776_RS13575	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HB776_RS13580	COG1116	anion transmembrane transporter activity
HB776_RS13580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS13585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS13590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS13630	COG0538	isocitrate dehydrogenase activity
HB776_RS13635	COG1505	serine-type exopeptidase activity
HB776_RS13645	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS13650	COG4651	solute:proton antiporter activity
HB776_RS13650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB776_RS13655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HB776_RS13660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HB776_RS13665	COG0509	glycine decarboxylation via glycine cleavage system
HB776_RS13670	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HB776_RS13670	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HB776_RS13675	COG3685	Protein conserved in bacteria
HB776_RS13680	COG1473	amidohydrolase
HB776_RS13705	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HB776_RS13715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB776_RS13720	COG1657	PFAM Prenyltransferase squalene oxidase
HB776_RS13725	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HB776_RS13730	COG1562	ergosterol biosynthetic process
HB776_RS13735	COG1562	ergosterol biosynthetic process
HB776_RS13765	COG4303	Ethanolamine ammonia lyase large subunit
HB776_RS13770	COG2081	HI0933 family
HB776_RS13790	COG2721	sulfolactate sulfo-lyase activity
HB776_RS13795	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS13825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS13830	COG1846	Transcriptional regulator
HB776_RS13840	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HB776_RS13865	COG1846	Transcriptional regulator
HB776_RS13870	COG3971	2-oxopent-4-enoate hydratase activity
HB776_RS13890	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_RS13895	COG0028	Belongs to the TPP enzyme family
HB776_RS13910	COG3145	DNA-N1-methyladenine dioxygenase activity
HB776_RS13945	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS13950	COG0477	Major facilitator Superfamily
HB776_RS13965	COG3386	PFAM SMP-30 Gluconolaconase
HB776_RS13970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HB776_RS13995	COG1024	Enoyl-CoA hydratase
HB776_RS14040	COG2267	carboxylic ester hydrolase activity
HB776_RS14045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB776_RS14045	COG2124	cytochrome p450
HB776_RS14060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_RS14065	COG0747	negative chemotaxis
HB776_RS14075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS14080	COG0444	Belongs to the ABC transporter superfamily
HB776_RS14085	COG4608	Belongs to the ABC transporter superfamily
HB776_RS14090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HB776_RS14205	COG2917	probably involved in intracellular septation
HB776_RS14225	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HB776_RS14225	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HB776_RS14265	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB776_RS14270	COG1684	flagellar biosynthetic protein fliR
HB776_RS14275	COG1987	bacterial-type flagellum assembly
HB776_RS14280	COG1677	Flagellar hook-basal body complex protein FliE
HB776_RS14285	COG1558	bacterial-type flagellum-dependent cell motility
HB776_RS14300	COG1338	Plays a role in the flagellum-specific transport system
HB776_RS14330	COG4786	Flagellar basal body rod
HB776_RS14335	COG4786	Flagellar basal body rod
HB776_RS14350	COG3971	2-oxopent-4-enoate hydratase activity
HB776_RS14370	COG1706	bacterial-type flagellum-dependent cell motility
HB776_RS14420	COG1256	bacterial-type flagellum assembly
HB776_RS14425	COG1749	Flagellar hook protein flgE
HB776_RS14430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB776_RS14435	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HB776_RS14435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_RS14460	COG3685	Protein conserved in bacteria
HB776_RS14475	COG0477	Major facilitator Superfamily
HB776_RS14480	COG0583	DNA-binding transcription factor activity
HB776_RS14495	COG0492	ferredoxin-NADP+ reductase activity
HB776_RS14505	COG0633	Ferredoxin
HB776_RS14530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB776_RS14530	COG3218	ABC-type transport auxiliary lipoprotein component
HB776_RS14535	COG1127	ABC transporter
HB776_RS14540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HB776_RS14545	COG4948	Mandelate Racemase Muconate Lactonizing
HB776_RS14550	COG2814	Major facilitator Superfamily
HB776_RS14565	COG0438	transferase activity, transferring glycosyl groups
HB776_RS14620	COG0351	phosphomethylpyrimidine kinase
HB776_RS14635	COG1522	sequence-specific DNA binding
HB776_RS14640	COG5001	Diguanylate cyclase
HB776_RS14640	COG3300	MHYT domain
HB776_RS14645	COG0697	spore germination
HB776_RS14650	COG0656	L-ascorbic acid biosynthetic process
HB776_RS14670	COG1129	ABC transporter
HB776_RS14690	COG2198	Histidine kinase
HB776_RS14690	COG5002	protein histidine kinase activity
HB776_RS14690	COG0784	Response regulator, receiver
HB776_RS14695	COG0745	RESPONSE REGULATOR receiver
HB776_RS14705	COG1053	succinate dehydrogenase
HB776_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS14730	COG1653	transport
HB776_RS14740	COG3833	ABC-type maltose transport systems, permease component
HB776_RS14745	COG0243	molybdopterin cofactor binding
HB776_RS14750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB776_RS14765	COG1116	anion transmembrane transporter activity
HB776_RS14770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS14775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS14785	COG3485	protocatechuate 3,4-dioxygenase
HB776_RS14795	COG1396	sequence-specific DNA binding
HB776_RS14800	COG1301	dicarboxylic acid transport
HB776_RS14815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_RS14835	COG3845	ABC transporter
HB776_RS14840	COG4603	Belongs to the binding-protein-dependent transport system permease family
HB776_RS14870	COG2080	2 iron, 2 sulfur cluster binding
HB776_RS14870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB776_RS14920	COG2267	carboxylic ester hydrolase activity
HB776_RS14930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB776_RS14935	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HB776_RS14955	COG1492	cobalamin metabolic process
HB776_RS14990	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HB776_RS15000	COG5001	Diguanylate cyclase
HB776_RS15000	COG3300	MHYT domain
HB776_RS15010	COG4221	oxidoreductase activity
HB776_RS15015	COG1960	acyl-CoA dehydrogenase activity
HB776_RS15035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_RS15040	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HB776_RS15060	COG1272	protein, Hemolysin III
HB776_RS15065	COG3106	COG3106 Predicted ATPase
HB776_RS15070	COG3768	UPF0283 membrane protein
HB776_RS15080	COG0640	Transcriptional regulator
HB776_RS15100	COG1278	Cold shock
HB776_RS15125	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HB776_RS15145	COG0625	glutathione transferase activity
HB776_RS15160	COG1704	LemA family
HB776_RS15165	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS15180	COG2814	Major facilitator Superfamily
HB776_RS15185	COG0297	glycogen (starch) synthase activity
HB776_RS15225	COG0583	DNA-binding transcription factor activity
HB776_RS15240	COG4771	TonB-dependent receptor
HB776_RS15250	COG4558	Periplasmic binding protein
HB776_RS15255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB776_RS15260	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HB776_RS15270	COG0402	S-adenosylhomocysteine deaminase activity
HB776_RS15275	COG2072	flavoprotein involved in K transport
HB776_RS15280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS15320	COG1012	belongs to the aldehyde dehydrogenase family
HB776_RS15360	COG0297	glycogen (starch) synthase activity
HB776_RS15410	COG1228	amidohydrolase
HB776_RS15415	COG0683	leucine binding
HB776_RS15425	COG4638	Rieske (2fe-2S)
HB776_RS15460	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HB776_RS15465	COG3454	Phosphonate metabolism
HB776_RS15470	COG4778	phosphonate C-P lyase system protein PhnL
HB776_RS15475	COG4107	phosphonate C-P lyase system protein PhnK
HB776_RS15480	COG3627	carbon phosphorus lyase activity
HB776_RS15485	COG3626	phosphonate metabolism
HB776_RS15490	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HB776_RS15495	COG3624	Phosphonate C-P lyase system protein PhnG
HB776_RS15500	COG2188	Transcriptional regulator
HB776_RS15510	COG0824	Thioesterase
HB776_RS15520	COG0604	alcohol dehydrogenase
HB776_RS15520	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS15520	COG3321	synthase
HB776_RS15530	COG1615	UPF0182 protein
HB776_RS15545	COG2255	four-way junction helicase activity
HB776_RS15555	COG0632	four-way junction helicase activity
HB776_RS15560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HB776_RS15575	COG0840	transmembrane signaling receptor activity
HB776_RS15600	COG1692	metallophosphoesterase
HB776_RS15605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB776_RS15635	COG0126	phosphoglycerate kinase activity
HB776_RS15650	COG3588	fructose-bisphosphate aldolase
HB776_RS15655	COG0352	thiamine-phosphate diphosphorylase activity
HB776_RS15665	COG0483	inositol monophosphate 1-phosphatase activity
HB776_RS15675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_RS15695	COG1132	(ABC) transporter
HB776_RS15700	COG0254	rRNA binding
HB776_RS15715	COG2755	lipolytic protein G-D-S-L family
HB776_RS15715	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB776_RS15730	COG0604	alcohol dehydrogenase
HB776_RS15755	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS15770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HB776_RS15775	COG4208	sulfate ABC transporter
HB776_RS15780	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HB776_RS15795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB776_RS15805	COG1648	precorrin-2 dehydrogenase activity
HB776_RS15805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB776_RS15820	COG4208	sulfate ABC transporter
HB776_RS15825	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HB776_RS15835	COG0840	transmembrane signaling receptor activity
HB776_RS15850	COG1388	LysM domain
HB776_RS15850	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_RS15855	COG0628	permease
HB776_RS15890	COG0583	DNA-binding transcription factor activity
HB776_RS15900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS15905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS15915	COG0784	Response regulator, receiver
HB776_RS15995	COG3321	synthase
HB776_RS15995	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS15995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB776_RS15995	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS15995	COG0300	oxidoreductase activity
HB776_RS16000	COG1024	Enoyl-CoA hydratase
HB776_RS16090	COG1024	Enoyl-CoA hydratase
HB776_RS16100	COG1960	acyl-CoA dehydrogenase activity
HB776_RS16105	COG1960	acyl-CoA dehydrogenase activity
HB776_RS16115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB776_RS16145	COG1797	cobyrinic acid a,c-diamide synthase activity
HB776_RS16160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB776_RS16180	COG0406	alpha-ribazole phosphatase activity
HB776_RS16185	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HB776_RS16210	COG0259	pyridoxamine-phosphate oxidase activity
HB776_RS16215	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS16220	COG0598	Magnesium transport protein CorA
HB776_RS16225	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_RS16225	COG1388	LysM domain
HB776_RS16235	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS16250	COG0505	Belongs to the CarA family
HB776_RS16260	COG3258	Cytochrome c
HB776_RS16280	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB776_RS16295	COG2080	2 iron, 2 sulfur cluster binding
HB776_RS16305	COG3800	Transcriptional regulator
HB776_RS16305	COG1396	sequence-specific DNA binding
HB776_RS16325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_RS16330	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_RS16335	COG1129	ABC transporter
HB776_RS16340	COG0277	FAD linked oxidase domain protein
HB776_RS16345	COG3485	protocatechuate 3,4-dioxygenase
HB776_RS16350	COG2084	Dehydrogenase
HB776_RS16355	COG0402	S-adenosylhomocysteine deaminase activity
HB776_RS16365	COG1609	Transcriptional regulator
HB776_RS16385	COG1129	ABC transporter
HB776_RS16390	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_RS16395	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_RS16400	COG1879	ABC-type sugar transport system periplasmic component
HB776_RS16430	COG3485	protocatechuate 3,4-dioxygenase
HB776_RS16435	COG1609	Transcriptional regulator
HB776_RS16450	COG3246	L-lysine catabolic process to acetate
HB776_RS16455	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_RS16460	COG1129	ABC transporter
HB776_RS16500	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_RS16510	COG1024	Enoyl-CoA hydratase
HB776_RS16515	COG2050	protein possibly involved in aromatic compounds catabolism
HB776_RS16530	COG1012	belongs to the aldehyde dehydrogenase family
HB776_RS16530	COG2030	dehydratase
HB776_RS16550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB776_RS16555	COG2151	metal-sulfur cluster biosynthetic enzyme
HB776_RS16560	COG3396	Phenylacetate-CoA oxygenase
HB776_RS16565	COG3460	Phenylacetate-CoA oxygenase
HB776_RS16570	COG3396	Phenylacetate-CoA oxygenase
HB776_RS16575	COG3327	negative regulation of DNA-templated transcription, initiation
HB776_RS16660	COG3237	CsbD-like
HB776_RS16690	COG4191	Histidine kinase
HB776_RS16690	COG0784	Response regulator, receiver
HB776_RS16705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB776_RS16710	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HB776_RS16715	COG2080	2 iron, 2 sulfur cluster binding
HB776_RS16720	COG1335	isochorismatase
HB776_RS16760	COG0784	Response regulator, receiver
HB776_RS16760	COG4191	Histidine kinase
HB776_RS16850	COG2943	transferase activity, transferring hexosyl groups
HB776_RS16855	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HB776_RS16930	COG0628	permease
HB776_RS16940	COG1278	Cold shock
HB776_RS17040	COG0776	regulation of translation
HB776_RS17055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB776_RS17130	COG3920	Histidine kinase
HB776_RS17145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_RS17155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_RS17165	COG0702	epimerase
HB776_RS17205	COG3920	Histidine kinase
HB776_RS17240	COG0784	Response regulator, receiver
HB776_RS17240	COG4191	Histidine kinase
HB776_RS17260	COG0588	phosphoglycerate mutase activity
HB776_RS17275	COG0038	chloride channel
HB776_RS17300	COG1012	belongs to the aldehyde dehydrogenase family
HB776_RS17325	COG1063	alcohol dehydrogenase
HB776_RS17350	COG1175	transmembrane transport
HB776_RS17360	COG1653	transport
HB776_RS17375	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB776_RS17375	COG0456	acetyltransferase
HB776_RS17390	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HB776_RS17405	COG1609	Transcriptional regulator
HB776_RS17415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_RS17420	COG1175	transmembrane transport
HB776_RS17460	COG1396	sequence-specific DNA binding
HB776_RS17475	COG0028	Belongs to the TPP enzyme family
HB776_RS17480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB776_RS17495	COG0604	alcohol dehydrogenase
HB776_RS17510	COG0596	Alpha beta hydrolase
HB776_RS17510	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB776_RS17515	COG0431	NADPH-dependent FMN reductase
HB776_RS17520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS17540	COG2188	Transcriptional regulator
HB776_RS17555	COG1012	belongs to the aldehyde dehydrogenase family
HB776_RS17570	COG1733	regulation of RNA biosynthetic process
HB776_RS17575	COG0702	epimerase
HB776_RS17620	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS17635	COG1802	Transcriptional regulator
HB776_RS17640	COG2186	Transcriptional regulator
HB776_RS17660	COG3052	prosthetic group binding
HB776_RS17695	COG1126	abc transporter atp-binding protein
HB776_RS17700	COG0765	amino acid transport
HB776_RS17715	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HB776_RS17725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HB776_RS17755	COG4948	Mandelate Racemase Muconate Lactonizing
HB776_RS17790	COG3958	Transketolase
HB776_RS17795	COG3959	Transketolase, thiamine diphosphate binding domain
HB776_RS17800	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS17805	COG0583	DNA-binding transcription factor activity
HB776_RS17815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB776_RS17825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_RS17835	COG0154	amidase activity
HB776_RS17855	COG0683	leucine binding
HB776_RS17865	COG0402	S-adenosylhomocysteine deaminase activity
HB776_RS17880	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS17890	COG1228	amidohydrolase
HB776_RS17910	COG4214	carbohydrate transport
HB776_RS18010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_RS18020	COG1129	ABC transporter
HB776_RS18030	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_RS18035	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_RS18060	COG3971	2-oxopent-4-enoate hydratase activity
HB776_RS18065	COG3485	protocatechuate 3,4-dioxygenase
HB776_RS18070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HB776_RS18090	COG2814	Major facilitator Superfamily
HB776_RS18095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB776_RS18100	COG2197	response regulator
HB776_RS18105	COG3916	Acyl-homoserine-lactone synthase
HB776_RS18155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB776_RS18155	COG2755	lipolytic protein G-D-S-L family
HB776_RS18165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB776_RS18175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HB776_RS18190	COG0582	viral genome integration into host DNA
HB776_RS18200	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HB776_RS18205	COG0424	maF-like protein
HB776_RS18210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB776_RS18215	COG5328	Belongs to the UPF0262 family
HB776_RS18220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB776_RS18230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB776_RS18265	COG3634	alkyl hydroperoxide reductase activity
HB776_RS18280	COG1522	sequence-specific DNA binding
HB776_RS18285	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS18290	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS18295	COG4608	Belongs to the ABC transporter superfamily
HB776_RS18300	COG0444	Belongs to the ABC transporter superfamily
HB776_RS18305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS18310	COG0601	transmembrane transport
HB776_RS18340	COG1794	racemase activity, acting on amino acids and derivatives
HB776_RS18375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB776_RS18380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HB776_RS18430	COG0765	amino acid transport
HB776_RS18435	COG0765	amino acid transport
HB776_RS18440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_RS18450	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HB776_RS18480	COG1278	Cold shock
HB776_RS18540	COG4451	ribulose bisphosphate carboxylase, small
HB776_RS18545	COG1850	ribulose-bisphosphate carboxylase activity
HB776_RS18565	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HB776_RS18585	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS18595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB776_RS18610	COG0747	negative chemotaxis
HB776_RS18620	COG3218	ABC-type transport auxiliary lipoprotein component
HB776_RS18620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB776_RS18625	COG1127	ABC transporter
HB776_RS18640	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HB776_RS18645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB776_RS18665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HB776_RS18670	COG4177	L-phenylalanine transmembrane transporter activity
HB776_RS18700	COG0251	oxidation-reduction process
HB776_RS18715	COG1126	abc transporter atp-binding protein
HB776_RS18725	COG3791	Glutathione-dependent formaldehyde-activating
HB776_RS18730	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB776_RS18805	COG0583	DNA-binding transcription factor activity
HB776_RS18825	COG1131	(ABC) transporter
HB776_RS18845	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB776_RS18870	COG1960	acyl-CoA dehydrogenase activity
HB776_RS18875	COG1024	Enoyl-CoA hydratase
HB776_RS18880	COG0737	Belongs to the 5'-nucleotidase family
HB776_RS18880	COG4085	toxin activity
HB776_RS18880	COG1525	nuclease
HB776_RS18885	COG5001	Diguanylate cyclase
HB776_RS18885	COG5002	protein histidine kinase activity
HB776_RS18890	COG0123	including yeast histone deacetylase and acetoin utilization protein
HB776_RS18895	COG1722	exodeoxyribonuclease VII activity
HB776_RS18905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HB776_RS18915	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HB776_RS18920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HB776_RS18925	COG2267	carboxylic ester hydrolase activity
HB776_RS18930	COG1960	acyl-CoA dehydrogenase activity
HB776_RS18940	COG1024	Enoyl-CoA hydratase
HB776_RS18945	COG0583	DNA-binding transcription factor activity
HB776_RS18950	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS18965	COG0583	DNA-binding transcription factor activity
HB776_RS18975	COG1546	Belongs to the CinA family
HB776_RS18975	COG1058	Belongs to the CinA family
HB776_RS18980	COG0444	Belongs to the ABC transporter superfamily
HB776_RS18985	COG0154	amidase activity
HB776_RS18995	COG4608	Belongs to the ABC transporter superfamily
HB776_RS19000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS19005	COG0601	transmembrane transport
HB776_RS19010	COG4166	transmembrane transport
HB776_RS19015	COG0747	negative chemotaxis
HB776_RS19020	COG0366	Alpha amylase catalytic
HB776_RS19030	COG0010	Belongs to the arginase family
HB776_RS19060	COG2205	protein histidine kinase activity
HB776_RS19060	COG0784	Response regulator, receiver
HB776_RS19070	COG0210	DNA helicase
HB776_RS19075	COG0583	DNA-binding transcription factor activity
HB776_RS19080	COG0346	lactoylglutathione lyase activity
HB776_RS19085	COG0400	carboxylic ester hydrolase activity
HB776_RS19100	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HB776_RS19110	COG5398	heme oxygenase
HB776_RS19115	COG0408	coproporphyrinogen oxidase activity
HB776_RS19120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HB776_RS19130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB776_RS19155	COG0683	leucine binding
HB776_RS19165	COG1129	ABC transporter
HB776_RS19175	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HB776_RS19180	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_RS19195	COG1116	anion transmembrane transporter activity
HB776_RS19195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS19200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS19215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB776_RS19245	COG0583	DNA-binding transcription factor activity
HB776_RS19295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_RS19300	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_RS19305	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS19325	COG2814	Major facilitator Superfamily
HB776_RS19330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HB776_RS19335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB776_RS19345	COG1522	sequence-specific DNA binding
HB776_RS19350	COG0492	ferredoxin-NADP+ reductase activity
HB776_RS19355	COG0583	DNA-binding transcription factor activity
HB776_RS19365	COG1937	Protein conserved in bacteria
HB776_RS19370	COG3300	MHYT domain
HB776_RS19370	COG5001	Diguanylate cyclase
HB776_RS19375	COG1192	Involved in chromosome partitioning
HB776_RS19510	COG2205	protein histidine kinase activity
HB776_RS19530	COG0642	Histidine kinase
HB776_RS19540	COG4774	siderophore transport
HB776_RS19545	COG1840	ABC-type Fe3 transport system, periplasmic component
HB776_RS19580	COG1177	transmembrane transport
HB776_RS19585	COG1176	ABC-type spermidine putrescine transport system, permease component I
HB776_RS19590	COG3842	ATPase activity
HB776_RS19595	COG3300	MHYT domain
HB776_RS19595	COG5001	Diguanylate cyclase
HB776_RS19600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_RS19635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HB776_RS19640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HB776_RS19645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HB776_RS19665	COG0387	Pfam Sodium calcium exchanger
HB776_RS19725	COG0861	Integral membrane protein TerC family
HB776_RS19730	COG2204	response regulator
HB776_RS19735	COG2989	Protein conserved in bacteria
HB776_RS19740	COG3108	Peptidase M15
HB776_RS19765	COG1764	response to oxidative stress
HB776_RS19790	COG0668	transmembrane transport
HB776_RS19800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HB776_RS19805	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS19840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB776_RS19855	COG2186	Transcriptional regulator
HB776_RS19870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_RS19880	COG0596	Alpha beta hydrolase
HB776_RS19885	COG2733	membrane
HB776_RS19895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_RS19900	COG0354	folic acid binding
HB776_RS19905	COG0519	Catalyzes the synthesis of GMP from XMP
HB776_RS19910	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HB776_RS19930	COG0028	Belongs to the TPP enzyme family
HB776_RS19935	COG1116	anion transmembrane transporter activity
HB776_RS19940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS19950	COG0154	amidase activity
HB776_RS19965	COG1054	Belongs to the UPF0176 family
HB776_RS19970	COG2900	Belongs to the SlyX family
HB776_RS19975	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS19990	COG0181	hydroxymethylbilane synthase activity
HB776_RS20005	COG1902	pentaerythritol trinitrate reductase activity
HB776_RS20015	COG2192	nodulation
HB776_RS20045	COG1126	abc transporter atp-binding protein
HB776_RS20050	COG0765	amino acid transport
HB776_RS20055	COG0765	amino acid transport
HB776_RS20070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HB776_RS20095	COG0483	inositol monophosphate 1-phosphatase activity
HB776_RS20100	COG0583	DNA-binding transcription factor activity
HB776_RS20110	COG1280	lysine exporter protein (LysE YggA)
HB776_RS20120	COG0071	Belongs to the small heat shock protein (HSP20) family
HB776_RS20130	COG0070	glutamate synthase
HB776_RS20130	COG0069	glutamate synthase activity
HB776_RS20130	COG0067	glutamate synthase
HB776_RS20165	COG3237	CsbD-like
HB776_RS20170	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS20175	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS20190	COG2951	lytic endotransglycosylase activity
HB776_RS20195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB776_RS20200	COG5001	Diguanylate cyclase
HB776_RS20200	COG3706	GGDEF domain
HB776_RS20200	COG2203	Gaf domain
HB776_RS20200	COG4251	negative regulation of phosphorylation
HB776_RS20235	COG0330	HflC and HflK could
HB776_RS20240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HB776_RS20275	COG0251	oxidation-reduction process
HB776_RS20280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB776_RS20290	COG4689	acetoacetate decarboxylase
HB776_RS20310	COG0523	cobalamin synthesis protein
HB776_RS20315	COG0803	Belongs to the bacterial solute-binding protein 9 family
HB776_RS20325	COG1121	(ABC) transporter
HB776_RS20335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HB776_RS20340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB776_RS20345	COG2271	Major facilitator Superfamily
HB776_RS20365	COG0174	glutamine synthetase
HB776_RS20370	COG0069	glutamate synthase activity
HB776_RS20375	COG2218	PFAM glutamate synthase alpha subunit domain protein
HB776_RS20380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HB776_RS20395	COG2309	aminopeptidase activity
HB776_RS20405	COG2226	methyltransferase
HB776_RS20410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB776_RS20415	COG2146	nitrite reductase [NAD(P)H] activity
HB776_RS20420	COG2116	formate transmembrane transporter activity
HB776_RS20425	COG0515	serine threonine protein kinase
HB776_RS20425	COG2815	serine threonine protein kinase
HB776_RS20435	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS20445	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS20515	COG0739	heme binding
HB776_RS20520	COG0702	epimerase
HB776_RS20525	COG0542	response to heat
HB776_RS20540	COG2813	Specifically methylates the guanine in position
HB776_RS20540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_RS20545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_RS20555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HB776_RS20560	COG0287	Prephenate dehydrogenase
HB776_RS20590	COG2884	Cell division ATP-binding protein ftsE
HB776_RS20600	COG2204	response regulator
HB776_RS20610	COG0019	diaminopimelate decarboxylase activity
HB776_RS20620	COG0165	Argininosuccinate lyase
HB776_RS20625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB776_RS20630	COG5507	3-demethylubiquinone-9 3-methyltransferase
HB776_RS20655	COG0583	DNA-binding transcription factor activity
HB776_RS20660	COG1942	4-Oxalocrotonate Tautomerase
HB776_RS20665	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_RS20670	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HB776_RS20675	COG2086	electron transfer activity
HB776_RS20695	COG0784	Response regulator, receiver
HB776_RS20695	COG2198	Histidine kinase
HB776_RS20695	COG5002	protein histidine kinase activity
HB776_RS20700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB776_RS20705	COG0583	DNA-binding transcription factor activity
HB776_RS20710	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS20720	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_RS20720	COG1388	LysM domain
HB776_RS20725	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HB776_RS20735	COG4772	TonB-dependent receptor
HB776_RS20745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB776_RS20760	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_RS20780	COG0038	chloride channel
HB776_RS20790	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS20795	COG1733	regulation of RNA biosynthetic process
HB776_RS20810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HB776_RS20810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB776_RS20845	COG4774	siderophore transport
HB776_RS20860	COG0582	viral genome integration into host DNA
HB776_RS20890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS20900	COG0598	Magnesium transport protein CorA
HB776_RS20910	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS20920	COG0306	phosphate transporter
HB776_RS20935	COG4191	Histidine kinase
HB776_RS20935	COG0784	Response regulator, receiver
HB776_RS20940	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HB776_RS20975	COG1238	metal cluster binding
HB776_RS20980	COG0140	phosphoribosyl-ATP diphosphatase activity
HB776_RS20995	COG1132	(ABC) transporter
HB776_RS21000	COG1686	Belongs to the peptidase S11 family
HB776_RS21005	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS21025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB776_RS21030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HB776_RS21050	COG2824	Alkylphosphonate utilization operon protein PhnA
HB776_RS21055	COG3047	cAMP biosynthetic process
HB776_RS21080	COG2358	TRAP transporter, solute receptor (TAXI family
HB776_RS21095	COG2358	TRAP transporter, solute receptor (TAXI family
HB776_RS21120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB776_RS21130	COG0494	nUDIX hydrolase
HB776_RS21140	COG1040	competence protein
HB776_RS21145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB776_RS21160	COG2766	serine protein kinase
HB776_RS21165	COG2718	Belongs to the UPF0229 family
HB776_RS21170	COG2719	SpoVR family
HB776_RS21185	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS21200	COG1846	Transcriptional regulator
HB776_RS21205	COG1764	response to oxidative stress
HB776_RS21260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB776_RS21270	COG0527	aspartate kinase activity
HB776_RS21280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HB776_RS21285	COG2890	protein-(glutamine-N5) methyltransferase activity
HB776_RS21340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_RS21415	COG5001	Diguanylate cyclase
HB776_RS21445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HB776_RS21470	COG1960	acyl-CoA dehydrogenase activity
HB776_RS21475	COG1024	Enoyl-CoA hydratase
HB776_RS21490	COG1024	Enoyl-CoA hydratase
HB776_RS21515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HB776_RS21595	COG2207	Transcriptional regulator
HB776_RS21600	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS21605	COG2203	Gaf domain
HB776_RS21605	COG3706	GGDEF domain
HB776_RS21605	COG5001	Diguanylate cyclase
HB776_RS21605	COG4251	negative regulation of phosphorylation
HB776_RS21610	COG5001	Diguanylate cyclase
HB776_RS21640	COG0825	malonyl-CoA metabolic process
HB776_RS21645	COG4977	sequence-specific DNA binding
HB776_RS21650	COG4221	oxidoreductase activity
HB776_RS21655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB776_RS21660	COG0653	protein targeting
HB776_RS21665	COG1285	pathogenesis
HB776_RS21670	COG3034	peptidoglycan biosynthetic process
HB776_RS21690	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB776_RS21695	COG3383	formate dehydrogenase (NAD+) activity
HB776_RS21710	COG0583	DNA-binding transcription factor activity
HB776_RS21760	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_RS21785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_RS21830	COG2010	Cytochrome c
HB776_RS21845	COG3278	Belongs to the heme-copper respiratory oxidase family
HB776_RS21850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB776_RS21855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HB776_RS21860	COG2271	Major facilitator Superfamily
HB776_RS21890	COG0326	Molecular chaperone. Has ATPase activity
HB776_RS21910	COG0840	transmembrane signaling receptor activity
HB776_RS21925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_RS21935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS21940	COG0129	dihydroxy-acid dehydratase activity
HB776_RS21945	COG3246	L-lysine catabolic process to acetate
HB776_RS21960	COG0514	ATP-dependent DNA helicase (RecQ)
HB776_RS21985	COG0583	DNA-binding transcription factor activity
HB776_RS21995	COG0601	transmembrane transport
HB776_RS22055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB776_RS22055	COG2111	Na H antiporter
HB776_RS22060	COG0651	ATP synthesis coupled electron transport
HB776_RS22065	COG1006	Multisubunit Na H antiporter MnhC subunit
HB776_RS22070	COG2111	Na H antiporter
HB776_RS22070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB776_RS22075	COG1320	monovalent cation:proton antiporter activity
HB776_RS22100	COG2235	arginine
HB776_RS22125	COG2197	response regulator
HB776_RS22135	COG0628	permease
HB776_RS22175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB776_RS22205	COG2188	Transcriptional regulator
HB776_RS22210	COG2084	Dehydrogenase
HB776_RS22235	COG0745	RESPONSE REGULATOR receiver
HB776_RS22240	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB776_RS22260	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS22295	COG0596	Alpha beta hydrolase
HB776_RS22300	COG0662	Cupin 2, conserved barrel domain protein
HB776_RS22310	COG4221	oxidoreductase activity
HB776_RS22330	COG2226	methyltransferase
HB776_RS22355	COG1475	DNA binding
HB776_RS22385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HB776_RS22405	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HB776_RS22410	COG1877	trehalose-phosphatase activity
HB776_RS22415	COG2271	Major facilitator Superfamily
HB776_RS22440	COG4172	Belongs to the ABC transporter superfamily
HB776_RS22445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS22450	COG0601	transmembrane transport
HB776_RS22470	COG0848	biopolymer transport protein
HB776_RS22480	COG1653	transport
HB776_RS22490	COG0784	Response regulator, receiver
HB776_RS22490	COG3437	response regulator, receiver
HB776_RS22505	COG1271	oxidase subunit
HB776_RS22510	COG1294	oxidase, subunit
HB776_RS22520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB776_RS22525	COG1960	acyl-CoA dehydrogenase activity
HB776_RS22530	COG1960	acyl-CoA dehydrogenase activity
HB776_RS22540	COG2514	catechol 2,3-dioxygenase activity
HB776_RS22550	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HB776_RS22565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB776_RS22640	COG0501	Belongs to the peptidase M48B family
HB776_RS22665	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS22685	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
HB776_RS22690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_RS22700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_RS22705	COG1116	anion transmembrane transporter activity
HB776_RS22710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS22715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS22720	COG5001	Diguanylate cyclase
HB776_RS22745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB776_RS22755	COG2226	methyltransferase
HB776_RS22810	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB776_RS22825	COG5443	negative regulation of bacterial-type flagellum assembly
HB776_RS22845	COG1749	Flagellar hook protein flgE
HB776_RS22850	COG0741	lytic transglycosylase activity
HB776_RS22885	COG1338	Plays a role in the flagellum-specific transport system
HB776_RS22895	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HB776_RS22905	COG1706	bacterial-type flagellum-dependent cell motility
HB776_RS22915	COG4786	Flagellar basal body rod
HB776_RS22920	COG1677	Flagellar hook-basal body complex protein FliE
HB776_RS22925	COG1558	bacterial-type flagellum-dependent cell motility
HB776_RS22930	COG1815	bacterial-type flagellum-dependent cell motility
HB776_RS22935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB776_RS22940	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB776_RS22945	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB776_RS22960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HB776_RS22970	COG4786	Flagellar basal body rod
HB776_RS22975	COG1157	protein secretion by the type III secretion system
HB776_RS22980	COG2986	histidine ammonia-lyase
HB776_RS23000	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS23025	COG0412	Dienelactone hydrolase
HB776_RS23040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB776_RS23050	COG0268	Binds directly to 16S ribosomal RNA
HB776_RS23055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HB776_RS23065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HB776_RS23090	COG1024	Enoyl-CoA hydratase
HB776_RS23095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_RS23105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB776_RS23115	COG1116	anion transmembrane transporter activity
HB776_RS23130	COG0402	S-adenosylhomocysteine deaminase activity
HB776_RS23135	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HB776_RS23145	COG3346	SURF1 family
HB776_RS23150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB776_RS23155	COG1845	cytochrome c oxidase, subunit III
HB776_RS23160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB776_RS23165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB776_RS23170	COG0477	Major facilitator Superfamily
HB776_RS23210	COG3278	Belongs to the heme-copper respiratory oxidase family
HB776_RS23250	COG0583	DNA-binding transcription factor activity
HB776_RS23260	COG1741	Belongs to the pirin family
HB776_RS23265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HB776_RS23310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB776_RS23320	COG0180	Tryptophanyl-tRNA synthetase
HB776_RS23355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB776_RS23360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HB776_RS23370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HB776_RS23375	COG1253	flavin adenine dinucleotide binding
HB776_RS23380	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HB776_RS23385	COG1396	sequence-specific DNA binding
HB776_RS23390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HB776_RS23415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HB776_RS23425	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HB776_RS23435	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HB776_RS23450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB776_RS23460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HB776_RS23465	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HB776_RS23470	COG4133	protoheme IX ABC transporter activity
HB776_RS23475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB776_RS23495	COG0670	Belongs to the BI1 family
HB776_RS23500	COG0577	efflux transmembrane transporter activity
HB776_RS23500	COG1136	(ABC) transporter
HB776_RS23505	COG4181	ATPase activity
HB776_RS23515	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HB776_RS23520	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HB776_RS23530	COG0045	succinate-CoA ligase (ADP-forming) activity
HB776_RS23535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HB776_RS23555	COG1309	transcriptional regulator
HB776_RS23565	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB776_RS23570	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS23575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB776_RS23585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_RS23595	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB776_RS23610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB776_RS23620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HB776_RS23625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HB776_RS23630	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HB776_RS23635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HB776_RS23640	COG0494	nUDIX hydrolase
HB776_RS23645	COG1051	belongs to the nudix hydrolase family
HB776_RS23655	COG0793	Belongs to the peptidase S41A family
HB776_RS23665	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HB776_RS23670	COG0799	negative regulation of ribosome biogenesis
HB776_RS23675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HB776_RS23680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HB776_RS23685	COG0583	DNA-binding transcription factor activity
HB776_RS23695	COG1335	isochorismatase
HB776_RS23700	COG0251	oxidation-reduction process
HB776_RS23705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS23710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_RS23715	COG1116	anion transmembrane transporter activity
HB776_RS23740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HB776_RS23745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HB776_RS23760	COG2264	protein methyltransferase activity
HB776_RS23770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB776_RS23780	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_RS23805	COG0138	bifunctional purine biosynthesis protein purh
HB776_RS23815	COG0405	Gamma-glutamyltransferase
HB776_RS23820	COG2814	Major facilitator Superfamily
HB776_RS23840	COG0534	Mate efflux family protein
HB776_RS23855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HB776_RS23880	COG3118	belongs to the thioredoxin family
HB776_RS23890	COG2835	tetraacyldisaccharide 4'-kinase activity
HB776_RS23915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_RS23920	COG1946	Acyl-CoA thioesterase
HB776_RS23925	COG0347	Belongs to the P(II) protein family
HB776_RS23930	COG0347	Belongs to the P(II) protein family
HB776_RS23935	COG0004	ammonium transporteR
HB776_RS23940	COG0436	Aminotransferase
HB776_RS23945	COG1674	ftsk spoiiie
HB776_RS23950	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HB776_RS23965	COG0745	RESPONSE REGULATOR receiver
HB776_RS23975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HB776_RS23985	COG0495	leucyl-tRNA aminoacylation
HB776_RS24010	COG0357	Ribosomal RNA small subunit methyltransferase G
HB776_RS24025	COG0445	tRNA wobble uridine modification
HB776_RS24030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HB776_RS24035	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HB776_RS24040	COG1981	membrane
HB776_RS24045	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HB776_RS24050	COG0424	maF-like protein
HB776_RS24055	COG0237	dephospho-CoA kinase activity
HB776_RS24075	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HB776_RS24095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HB776_RS24100	COG0131	Imidazoleglycerol-phosphate dehydratase
HB776_RS24110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB776_RS24115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HB776_RS24125	COG0140	phosphoribosyl-ATP diphosphatase activity
HB776_RS24130	COG1072	(Pantothenic acid kinase))
HB776_RS24140	COG5002	protein histidine kinase activity
HB776_RS24140	COG0784	Response regulator, receiver
HB776_RS24140	COG2205	protein histidine kinase activity
HB776_RS24155	COG5002	protein histidine kinase activity
HB776_RS24155	COG3447	MASE1 domain protein
HB776_RS24155	COG5001	Diguanylate cyclase
HB776_RS24175	COG0792	nuclease activity
HB776_RS24180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HB776_RS24190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB776_RS24195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HB776_RS24200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HB776_RS24205	COG1420	regulation of RNA biosynthetic process
HB776_RS24210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HB776_RS24215	COG1335	isochorismatase
HB776_RS24225	COG0443	Heat shock 70 kDa protein
HB776_RS24230	COG0484	heat shock protein binding
HB776_RS24235	COG3963	phosphatidate phosphatase activity
HB776_RS24240	COG0431	NADPH-dependent FMN reductase
HB776_RS24245	COG0284	orotidine-5'-phosphate decarboxylase activity
HB776_RS24255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HB776_RS24260	COG0588	phosphoglycerate mutase activity
HB776_RS24270	COG1802	Transcriptional regulator
HB776_RS24275	COG1012	belongs to the aldehyde dehydrogenase family
HB776_RS24280	COG2814	Major facilitator Superfamily
HB776_RS24285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB776_RS24295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB776_RS24310	COG1175	transmembrane transport
HB776_RS24330	COG1234	tRNA 3'-trailer cleavage
HB776_RS24340	COG0072	phenylalanine-tRNA ligase activity
HB776_RS24340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB776_RS24345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HB776_RS24350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HB776_RS24355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HB776_RS24380	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB776_RS24390	COG1968	undecaprenyl-diphosphatase activity
HB776_RS24405	COG4974	Belongs to the 'phage' integrase family
HB776_RS24415	COG1476	TRANSCRIPTIONal
HB776_RS24460	COG0800	Aldolase
HB776_RS24465	COG3734	2-keto-3-deoxy-galactonokinase
HB776_RS24485	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HB776_RS24490	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HB776_RS24495	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HB776_RS24500	COG2205	protein histidine kinase activity
HB776_RS24515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_RS24520	COG2368	4-hydroxyphenylacetate
HB776_RS24545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HB776_RS24550	COG1137	ATPase activity
HB776_RS24555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HB776_RS24560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HB776_RS24565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB776_RS24585	COG0071	Belongs to the small heat shock protein (HSP20) family
HB776_RS24590	COG3842	ATPase activity
HB776_RS24595	COG0395	ABC-type sugar transport system, permease component
HB776_RS24600	COG1175	transmembrane transport
HB776_RS24605	COG1653	transport
HB776_RS24610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_RS24615	COG1764	response to oxidative stress
HB776_RS24620	COG1846	Transcriptional regulator
HB776_RS24640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HB776_RS24645	COG0539	negative regulation of cytoplasmic translation
HB776_RS24650	COG0616	signal peptide processing
HB776_RS24655	COG0776	regulation of translation
HB776_RS24665	COG0135	phosphoribosylanthranilate isomerase activity
HB776_RS24670	COG0133	tryptophan synthase activity
HB776_RS24675	COG0159	tryptophan synthase activity
HB776_RS24680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HB776_RS24685	COG0285	dihydrofolate synthase activity
HB776_RS24700	COG1074	ATP-dependent DNA helicase activity
HB776_RS24720	COG3178	'Phosphotransferase
HB776_RS24725	COG2205	protein histidine kinase activity
HB776_RS24730	COG0756	dUTP diphosphatase activity
HB776_RS24735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB776_RS24740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HB776_RS24745	COG2226	methyltransferase
HB776_RS24750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HB776_RS24760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS24765	COG2226	methyltransferase
HB776_RS24775	COG1487	ribonuclease activity
HB776_RS24790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HB776_RS24795	COG0667	Aldo Keto reductase
HB776_RS24810	COG0779	Required for maturation of 30S ribosomal subunits
HB776_RS24825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HB776_RS24830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HB776_RS24835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HB776_RS24840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HB776_RS24850	COG1185	polyribonucleotide nucleotidyltransferase activity
HB776_RS24860	COG2917	probably involved in intracellular septation
HB776_RS24865	COG0552	protein localization to endoplasmic reticulum
HB776_RS24870	COG0564	pseudouridine synthase activity
HB776_RS24875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HB776_RS24895	COG2910	NAD(P)H-binding
HB776_RS24905	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB776_RS24910	COG0228	four-way junction DNA binding
HB776_RS24920	COG0702	epimerase
HB776_RS24930	COG0335	large ribosomal subunit rRNA binding
HB776_RS24940	COG3214	Protein conserved in bacteria
HB776_RS24970	COG0066	3-isopropylmalate dehydratase activity
HB776_RS24980	COG2301	Belongs to the HpcH HpaI aldolase family
HB776_RS24985	COG0288	reversible hydration of carbon dioxide
HB776_RS24990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HB776_RS25005	COG0473	3-isopropylmalate dehydrogenase activity
HB776_RS25010	COG0477	Major facilitator Superfamily
HB776_RS25015	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HB776_RS25020	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HB776_RS25025	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HB776_RS25030	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS25040	COG0730	response to heat
HB776_RS25065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS25075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS25085	COG4178	(ABC) transporter
HB776_RS25110	COG1785	Belongs to the alkaline phosphatase family
HB776_RS25115	COG1309	transcriptional regulator
HB776_RS25125	COG0137	argininosuccinate synthase activity
HB776_RS25130	COG0671	phosphoesterase, PA-phosphatase related
HB776_RS25140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HB776_RS25150	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS25165	COG2154	pterin-4-alpha-carbinolamine dehydratase
HB776_RS25180	COG4774	siderophore transport
HB776_RS25190	COG1217	gtp-binding protein TYPA
HB776_RS25195	COG0625	glutathione transferase activity
HB776_RS25205	COG3011	Protein conserved in bacteria
HB776_RS25215	COG1247	-acetyltransferase
HB776_RS25220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HB776_RS25225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_RS25230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HB776_RS25235	COG1872	DUF167
HB776_RS25250	COG4221	oxidoreductase activity
HB776_RS25280	COG2814	Major facilitator Superfamily
HB776_RS25290	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HB776_RS25295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HB776_RS25310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HB776_RS25315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HB776_RS25320	COG4948	Mandelate Racemase Muconate Lactonizing
HB776_RS25325	COG0583	DNA-binding transcription factor activity
HB776_RS25395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_RS25405	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB776_RS25405	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HB776_RS25415	COG1760	l-serine dehydratase
HB776_RS25420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HB776_RS25445	COG0411	ABC transporter
HB776_RS25475	COG1595	DNA-templated transcription, initiation
HB776_RS25480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HB776_RS25485	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HB776_RS25500	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HB776_RS25505	COG1749	Flagellar hook protein flgE
HB776_RS25535	COG2197	response regulator
HB776_RS25540	COG2197	response regulator
HB776_RS25545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB776_RS25550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HB776_RS25555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB776_RS25560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_RS25570	COG1596	polysaccharide export
HB776_RS25580	COG0438	transferase activity, transferring glycosyl groups
HB776_RS25595	COG2894	cell division
HB776_RS25680	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_RS25715	COG4566	intracellular signal transduction
HB776_RS25720	COG4566	intracellular signal transduction
HB776_RS25725	COG4191	Histidine kinase
HB776_RS25760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_RS25775	COG0402	S-adenosylhomocysteine deaminase activity
HB776_RS25790	COG0488	(ABC) transporter
HB776_RS25795	COG1522	sequence-specific DNA binding
HB776_RS25800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB776_RS25805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_RS25820	COG0243	molybdopterin cofactor binding
HB776_RS25825	COG0243	molybdopterin cofactor binding
HB776_RS25835	COG1902	pentaerythritol trinitrate reductase activity
HB776_RS25840	COG0243	molybdopterin cofactor binding
HB776_RS25900	COG0025	NhaP-type Na H and K H
HB776_RS25905	COG0438	transferase activity, transferring glycosyl groups
HB776_RS25915	COG1132	(ABC) transporter
HB776_RS25935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB776_RS26010	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HB776_RS26015	COG3813	Protein conserved in bacteria
HB776_RS26020	COG1522	sequence-specific DNA binding
HB776_RS26030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_RS26055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB776_RS26075	COG1335	isochorismatase
HB776_RS26085	COG0617	tRNA 3'-terminal CCA addition
HB776_RS26085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HB776_RS26085	COG0517	IMP dehydrogenase activity
HB776_RS26110	COG5002	protein histidine kinase activity
HB776_RS26115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HB776_RS26120	COG0573	inorganic phosphate transmembrane transporter activity
HB776_RS26125	COG0581	inorganic phosphate transmembrane transporter activity
HB776_RS26130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB776_RS26135	COG0704	Plays a role in the regulation of phosphate uptake
HB776_RS26140	COG0745	RESPONSE REGULATOR receiver
HB776_RS26150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB776_RS26155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HB776_RS26200	COG0717	Belongs to the dCTP deaminase family
HB776_RS26215	COG0667	Aldo Keto reductase
HB776_RS26225	COG2721	sulfolactate sulfo-lyase activity
HB776_RS26270	COG0598	Magnesium transport protein CorA
HB776_RS26290	COG1999	signal sequence binding
HB776_RS26305	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HB776_RS26325	COG0167	dihydroorotate dehydrogenase activity
HB776_RS26330	COG0534	Mate efflux family protein
HB776_RS26340	COG1793	dna ligase
HB776_RS26355	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB776_RS26375	COG1201	RNA secondary structure unwinding
HB776_RS26390	COG0583	DNA-binding transcription factor activity
HB776_RS26415	COG0730	response to heat
HB776_RS26440	COG1960	acyl-CoA dehydrogenase activity
HB776_RS26445	COG0183	Belongs to the thiolase family
HB776_RS26450	COG1024	Enoyl-CoA hydratase
HB776_RS26450	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_RS26495	COG0681	Belongs to the peptidase S26 family
HB776_RS26500	COG0312	modulator of DNA gyrase
HB776_RS26510	COG1733	regulation of RNA biosynthetic process
HB776_RS26535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB776_RS26540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB776_RS26545	COG0109	protoheme IX farnesyltransferase activity
HB776_RS26555	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HB776_RS26570	COG3346	SURF1 family
HB776_RS26580	COG0612	Peptidase, M16
HB776_RS26585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB776_RS26595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HB776_RS26610	COG0356	it plays a direct role in the translocation of protons across the membrane
HB776_RS26640	COG0432	Pfam Uncharacterised protein family UPF0047
HB776_RS26655	COG0784	Response regulator, receiver
HB776_RS26655	COG2198	Histidine kinase
HB776_RS26655	COG2205	protein histidine kinase activity
HB776_RS26665	COG0156	8-amino-7-oxononanoate synthase activity
HB776_RS26675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HB776_RS26695	COG0129	dihydroxy-acid dehydratase activity
HB776_RS26700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB776_RS26715	COG2176	DNA-directed DNA polymerase activity
HB776_RS26725	COG0183	Belongs to the thiolase family
HB776_RS26730	COG0402	S-adenosylhomocysteine deaminase activity
HB776_RS26750	COG1132	(ABC) transporter
HB776_RS26760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB776_RS26775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HB776_RS26780	COG1228	amidohydrolase
HB776_RS26785	COG0402	S-adenosylhomocysteine deaminase activity
HB776_RS26815	COG2202	Pas domain
HB776_RS26815	COG2200	EAL domain
HB776_RS26815	COG2199	diguanylate cyclase activity
HB776_RS26820	COG4191	Histidine kinase
HB776_RS26820	COG0784	Response regulator, receiver
HB776_RS26825	COG4191	Histidine kinase
HB776_RS26825	COG0784	Response regulator, receiver
HB776_RS26835	COG2130	NADP-dependent
HB776_RS26840	COG1301	dicarboxylic acid transport
HB776_RS26850	COG0285	dihydrofolate synthase activity
HB776_RS26855	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB776_RS26855	COG2918	glutathione biosynthetic process
HB776_RS26865	COG0069	glutamate synthase activity
HB776_RS26895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS26900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB776_RS26915	COG2003	Belongs to the UPF0758 family
HB776_RS26920	COG0024	Methionine aminopeptidase
HB776_RS26925	COG1489	DNA binding
HB776_RS26930	COG3264	Mechanosensitive ion channel
HB776_RS26930	COG1511	domain protein
HB776_RS26940	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB776_RS26945	COG4149	molybdate abc transporter
HB776_RS26960	COG3585	molybdate ion transport
HB776_RS26965	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HB776_RS26970	COG5001	Diguanylate cyclase
HB776_RS26980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_RS26990	COG0583	DNA-binding transcription factor activity
HB776_RS27000	COG0640	Transcriptional regulator
HB776_RS27005	COG1393	Belongs to the ArsC family
HB776_RS27010	COG0798	PFAM Bile acid sodium symporter
HB776_RS27030	COG0481	GTPase activity
HB776_RS27040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB776_RS27045	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB776_RS27045	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB776_RS27050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HB776_RS27055	COG2205	protein histidine kinase activity
HB776_RS27060	COG0745	RESPONSE REGULATOR receiver
HB776_RS27070	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HB776_RS27080	COG0058	SHG alpha-glucan phosphorylase activity
HB776_RS27100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HB776_RS27105	COG0625	glutathione transferase activity
HB776_RS27110	COG1280	lysine exporter protein (LysE YggA)
HB776_RS27120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB776_RS27120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB776_RS27135	COG1643	Atp-dependent helicase
HB776_RS27140	COG3577	Aspartyl protease
HB776_RS27145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB776_RS27150	COG0583	DNA-binding transcription factor activity
HB776_RS27155	COG2855	membrane
HB776_RS27160	COG1522	sequence-specific DNA binding
HB776_RS27185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB776_RS27190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HB776_RS27195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB776_RS27205	COG2223	nitrite transmembrane transporter activity
HB776_RS27215	COG0242	peptide deformylase activity
HB776_RS27220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HB776_RS27225	COG0101	tRNA pseudouridine synthase activity
HB776_RS27230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB776_RS27235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_RS27245	COG2171	N-acyltransferase activity
HB776_RS27260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HB776_RS27270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HB776_RS27275	COG0706	membrane insertase activity
HB776_RS27285	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HB776_RS27290	COG3852	Histidine kinase
HB776_RS27300	COG2902	Dehydrogenase
HB776_RS27310	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_RS27315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_RS27320	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_RS27325	COG3971	2-oxopent-4-enoate hydratase activity
HB776_RS27330	COG0251	oxidation-reduction process
HB776_RS27345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB776_RS27350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB776_RS27380	COG0330	HflC and HflK could
HB776_RS27405	COG1473	amidohydrolase
HB776_RS27420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HB776_RS27420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HB776_RS27425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_RS27430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_RS27455	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HB776_RS27460	COG0235	Class ii aldolase
HB776_RS27465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB776_RS27475	COG2814	Major facilitator Superfamily
HB776_RS27540	COG3300	MHYT domain
HB776_RS27540	COG5001	Diguanylate cyclase
HB776_RS27555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HB776_RS27560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB776_RS27585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HB776_RS27595	COG0735	belongs to the Fur family
HB776_RS27615	COG1566	PFAM secretion protein HlyD family protein
HB776_RS27620	COG2814	Major facilitator Superfamily
HB776_RS27625	COG3485	protocatechuate 3,4-dioxygenase
HB776_RS27630	COG3485	protocatechuate 3,4-dioxygenase
HB776_RS27635	COG0183	Belongs to the thiolase family
HB776_RS27640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HB776_RS27660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS27670	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HB776_RS27680	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HB776_RS27700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB776_RS27715	COG4974	Belongs to the 'phage' integrase family
HB776_RS27730	COG1309	transcriptional regulator
HB776_RS27740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HB776_RS27745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HB776_RS27750	COG1253	flavin adenine dinucleotide binding
HB776_RS27785	COG0683	leucine binding
HB776_RS27795	COG0402	S-adenosylhomocysteine deaminase activity
HB776_RS27800	COG0154	amidase activity
HB776_RS27805	COG2183	response to ionizing radiation
HB776_RS27810	COG0443	Heat shock 70 kDa protein
HB776_RS27855	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_RS27855	COG1024	Enoyl-CoA hydratase
HB776_RS27860	COG1607	acyl-coa hydrolase
HB776_RS27880	COG3842	ATPase activity
HB776_RS27885	COG3842	ATPase activity
HB776_RS27895	COG0395	ABC-type sugar transport system, permease component
HB776_RS27910	COG1902	pentaerythritol trinitrate reductase activity
HB776_RS27950	COG1051	belongs to the nudix hydrolase family
HB776_RS28000	COG0714	Associated with various cellular activities
HB776_RS28020	COG0617	tRNA 3'-terminal CCA addition
HB776_RS28060	COG0602	queuosine metabolic process
HB776_RS28075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HB776_RS28085	COG4774	siderophore transport
HB776_RS28090	COG4774	siderophore transport
HB776_RS28100	COG0723	plastoquinol--plastocyanin reductase activity
HB776_RS28105	COG2857	Cytochrome c1
HB776_RS28105	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HB776_RS28110	COG0385	Bile acid
HB776_RS28115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB776_RS28145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HB776_RS28175	COG1566	PFAM secretion protein HlyD family protein
HB776_RS28200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_RS28210	COG0438	transferase activity, transferring glycosyl groups
HB776_RS28215	COG0583	DNA-binding transcription factor activity
HB776_RS28220	COG1741	Belongs to the pirin family
HB776_RS28225	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB776_RS28235	COG3585	molybdate ion transport
HB776_RS28235	COG2005	Transcriptional regulator
HB776_RS28240	COG1618	nucleotide phosphatase activity, acting on free nucleotides
HB776_RS28240	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB776_RS28245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HB776_RS28250	COG0477	Major facilitator Superfamily
HB776_RS28265	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS28270	COG0662	Cupin 2, conserved barrel domain protein
HB776_RS28270	COG2207	Transcriptional regulator
HB776_RS28290	COG0604	alcohol dehydrogenase
HB776_RS28295	COG0142	geranyltranstransferase activity
HB776_RS28305	COG2890	protein-(glutamine-N5) methyltransferase activity
HB776_RS28320	COG0752	glycyl-tRNA synthetase alpha subunit
HB776_RS28325	COG0751	glycine-tRNA ligase activity
HB776_RS28345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB776_RS28345	COG0574	Belongs to the PEP-utilizing enzyme family
HB776_RS28365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HB776_RS28370	COG0604	alcohol dehydrogenase
HB776_RS28380	COG0501	Belongs to the peptidase M48B family
HB776_RS28385	COG1704	LemA family
HB776_RS28410	COG1196	nuclear chromosome segregation
HB776_RS28430	COG2076	Multidrug Resistance protein
HB776_RS28435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HB776_RS28435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB776_RS28445	COG1194	a g-specific adenine glycosylase
HB776_RS28455	COG0840	transmembrane signaling receptor activity
HB776_RS28480	COG0625	glutathione transferase activity
HB776_RS28485	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HB776_RS28490	COG2321	neutral zinc metallopeptidase
HB776_RS28495	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB776_RS28520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB776_RS28530	COG1573	uracil-dna glycosylase
HB776_RS28545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HB776_RS28550	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS28555	COG0473	3-isopropylmalate dehydrogenase activity
HB776_RS28560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB776_RS28575	COG4336	lyase activity
HB776_RS28615	COG0235	Class ii aldolase
HB776_RS28620	COG2084	Dehydrogenase
HB776_RS28625	COG3622	Belongs to the hyi family
HB776_RS28630	COG3395	kinase activity
HB776_RS28635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB776_RS28640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_RS28655	COG2070	2-Nitropropane dioxygenase
HB776_RS28660	COG2072	flavoprotein involved in K transport
HB776_RS28670	COG1024	Enoyl-CoA hydratase
HB776_RS28685	COG1024	Enoyl-CoA hydratase
HB776_RS28715	COG2135	peptidase activity
HB776_RS28720	COG0456	acetyltransferase
HB776_RS28725	COG0277	FAD linked oxidase domain protein
HB776_RS28730	COG0009	L-threonylcarbamoyladenylate synthase
HB776_RS28740	COG2186	Transcriptional regulator
HB776_RS28755	COG3842	ATPase activity
HB776_RS28765	COG0395	ABC-type sugar transport system, permease component
HB776_RS28775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB776_RS28785	COG0392	lysyltransferase activity
HB776_RS28785	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HB776_RS28820	COG0683	leucine binding
HB776_RS28825	COG0346	lactoylglutathione lyase activity
HB776_RS28840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_RS28845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB776_RS28875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_RS28895	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB776_RS28895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HB776_RS28905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_RS28910	COG0656	L-ascorbic acid biosynthetic process
HB776_RS28915	COG0864	Transcriptional regulator
HB776_RS28920	COG4774	siderophore transport
HB776_RS28925	COG2706	6-phosphogluconolactonase activity
HB776_RS28935	COG1960	acyl-CoA dehydrogenase activity
HB776_RS28940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB776_RS28940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB776_RS28945	COG0475	glutathione-regulated potassium exporter activity
HB776_RS28945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB776_RS28950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB776_RS28960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB776_RS28970	COG1280	lysine exporter protein (LysE YggA)
HB776_RS28995	COG2814	Major facilitator Superfamily
HB776_RS29010	COG3253	May function as heme-dependent peroxidase
HB776_RS29025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB776_RS29040	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HB776_RS29060	COG2951	lytic endotransglycosylase activity
HB776_RS29090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB776_RS29095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB776_RS29125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB776_RS29135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB776_RS29140	COG1766	The M ring may be actively involved in energy transduction
HB776_RS29150	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HB776_RS29160	COG0482	sulfurtransferase activity
HB776_RS29175	COG1082	Xylose isomerase domain protein TIM barrel
HB776_RS29175	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HB776_RS29190	COG4177	L-phenylalanine transmembrane transporter activity
HB776_RS29205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HB776_RS29210	COG0583	DNA-binding transcription factor activity
HB776_RS29215	COG0438	transferase activity, transferring glycosyl groups
HB776_RS29235	COG0405	Gamma-glutamyltransferase
HB776_RS29240	COG2199	diguanylate cyclase activity
HB776_RS29245	COG0523	cobalamin synthesis protein
HB776_RS29250	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HB776_RS29255	COG3454	Phosphonate metabolism
HB776_RS29265	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HB776_RS29275	COG3639	organic phosphonate transmembrane transporter activity
HB776_RS29280	COG3639	organic phosphonate transmembrane transporter activity
HB776_RS29285	COG0625	glutathione transferase activity
HB776_RS29295	COG3795	YCII-related domain
HB776_RS29300	COG4941	Belongs to the sigma-70 factor family
HB776_RS29315	COG2814	Major facilitator Superfamily
HB776_RS29325	COG4774	siderophore transport
HB776_RS29330	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS29355	COG1335	isochorismatase
HB776_RS29360	COG0583	DNA-binding transcription factor activity
HB776_RS29370	COG3795	YCII-related domain
HB776_RS29375	COG1309	transcriptional regulator
HB776_RS29390	COG0848	biopolymer transport protein
HB776_RS29400	COG0823	Involved in the tonB-independent uptake of proteins
HB776_RS29405	COG5001	Diguanylate cyclase
HB776_RS29415	COG2885	chlorophyll binding
HB776_RS29430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB776_RS29455	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HB776_RS29455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB776_RS29460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB776_RS29475	COG1309	transcriptional regulator
HB776_RS29480	COG3474	cytochrome
HB776_RS29485	COG0277	FAD linked oxidase domain protein
HB776_RS29490	COG0277	FAD linked oxidase domain protein
HB776_RS29495	COG0247	lactate metabolic process
HB776_RS29515	COG4178	(ABC) transporter
HB776_RS29520	COG1620	l-lactate permease
HB776_RS29535	COG0459	protein refolding
HB776_RS29540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HB776_RS29560	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_RS29560	COG1388	LysM domain
HB776_RS29565	COG3416	Protein conserved in bacteria
HB776_RS29590	COG0463	Glycosyl transferase, family 2
HB776_RS29595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HB776_RS29600	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HB776_RS29620	COG0583	DNA-binding transcription factor activity
HB776_RS29630	COG0028	Belongs to the TPP enzyme family
HB776_RS29630	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HB776_RS29640	COG0277	FAD linked oxidase domain protein
HB776_RS29650	COG0312	modulator of DNA gyrase
HB776_RS29655	COG0483	inositol monophosphate 1-phosphatase activity
HB776_RS29670	COG1519	Transferase
HB776_RS29675	COG1663	tetraacyldisaccharide 4'-kinase activity
HB776_RS29685	COG1570	exodeoxyribonuclease VII activity
HB776_RS29710	COG0151	Belongs to the GarS family
HB776_RS29720	COG0590	tRNA wobble adenosine to inosine editing
HB776_RS29725	COG1187	pseudouridine synthase activity
HB776_RS29730	COG0742	ribosomal rna small subunit methyltransferase
HB776_RS29740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HB776_RS29755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HB776_RS29760	COG0612	Peptidase, M16
HB776_RS29765	COG0612	Peptidase, M16
HB776_RS29775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HB776_RS29780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB776_RS29790	COG0196	riboflavin kinase activity
HB776_RS29795	COG0745	RESPONSE REGULATOR receiver
HB776_RS29810	COG1295	ribonuclease BN
HB776_RS29820	COG0124	histidyl-tRNA synthetase
HB776_RS29825	COG1942	4-Oxalocrotonate Tautomerase
HB776_RS29855	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HB776_RS29860	COG1278	Cold shock
HB776_RS29870	COG0322	excinuclease ABC activity
HB776_RS29875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB776_RS29885	COG0314	molybdopterin synthase activity
HB776_RS29890	COG2890	protein-(glutamine-N5) methyltransferase activity
HB776_RS29900	COG0534	Mate efflux family protein
HB776_RS29910	COG1846	Transcriptional regulator
HB776_RS29915	COG0745	RESPONSE REGULATOR receiver
HB776_RS29925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HB776_RS29930	COG0456	acetyltransferase
HB776_RS29940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HB776_RS29945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB776_RS29975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HB776_RS29980	COG0193	aminoacyl-tRNA hydrolase activity
HB776_RS29985	COG0012	GTP binding
HB776_RS29995	COG2030	dehydratase
HB776_RS30045	COG1301	dicarboxylic acid transport
HB776_RS30050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB776_RS30070	COG0556	nucleotide-excision repair
HB776_RS30080	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HB776_RS30105	COG1999	signal sequence binding
HB776_RS30115	COG0625	glutathione transferase activity
HB776_RS30125	COG3706	GGDEF domain
HB776_RS30145	COG0667	Aldo Keto reductase
HB776_RS30165	COG2133	pyrroloquinoline quinone binding
HB776_RS30185	COG0436	Aminotransferase
HB776_RS30200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HB776_RS30215	COG0659	secondary active sulfate transmembrane transporter activity
HB776_RS30220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HB776_RS30235	COG1304	FMN binding
HB776_RS30245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB776_RS30260	COG0625	glutathione transferase activity
HB776_RS30270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HB776_RS30275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_RS30280	COG0840	transmembrane signaling receptor activity
HB776_RS30290	COG0840	transmembrane signaling receptor activity
HB776_RS30325	COG3290	protein histidine kinase activity
HB776_RS30325	COG0840	transmembrane signaling receptor activity
HB776_RS30330	COG4774	siderophore transport
HB776_RS30350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB776_RS30370	COG2140	Oxalate decarboxylase
HB776_RS30380	COG0384	phenazine biosynthesis protein PhzF
HB776_RS30395	COG1278	Cold shock
HB776_RS30405	COG4191	Histidine kinase
HB776_RS30405	COG0784	Response regulator, receiver
HB776_RS30410	COG2202	Pas domain
HB776_RS30410	COG3920	Histidine kinase
HB776_RS30425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB776_RS30435	COG4774	siderophore transport
HB776_RS30445	COG2514	catechol 2,3-dioxygenase activity
HB776_RS30490	COG2207	Transcriptional regulator
HB776_RS30505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB776_RS30530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS30535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_RS30540	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS30550	COG2186	Transcriptional regulator
HB776_RS30565	COG4106	trans-aconitate 2-methyltransferase activity
HB776_RS30645	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_RS30650	COG0183	Belongs to the thiolase family
HB776_RS30655	COG1960	acyl-CoA dehydrogenase activity
HB776_RS30665	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_RS30670	COG0445	tRNA wobble uridine modification
HB776_RS30675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB776_RS30695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_RS30705	COG3795	YCII-related domain
HB776_RS30710	COG0077	Prephenate dehydratase
HB776_RS30710	COG1605	Chorismate mutase
HB776_RS30715	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HB776_RS30720	COG3474	cytochrome
HB776_RS30725	COG4166	transmembrane transport
HB776_RS30730	COG4166	transmembrane transport
HB776_RS30735	COG4174	ABC transporter (Permease)
HB776_RS30740	COG4239	(ABC) transporter, permease
HB776_RS30745	COG4172	Belongs to the ABC transporter superfamily
HB776_RS30760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HB776_RS30795	COG4964	Belongs to the GSP D family
HB776_RS30835	COG1278	Cold shock
HB776_RS30840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HB776_RS30845	COG0513	Belongs to the DEAD box helicase family
HB776_RS30865	COG1129	ABC transporter
HB776_RS30875	COG0829	nickel cation binding
HB776_RS30880	COG0831	urea catabolic process
HB776_RS30885	COG0832	Belongs to the urease beta subunit family
HB776_RS30900	COG0804	urea catabolic process
HB776_RS30910	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HB776_RS30915	COG0830	nickel cation binding
HB776_RS30930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB776_RS31015	COG0454	-acetyltransferase
HB776_RS31040	COG1278	Cold shock
HB776_RS31050	COG3293	Transposase
HB776_RS31055	COG3300	MHYT domain
HB776_RS31055	COG5001	Diguanylate cyclase
HB776_RS31060	COG3706	GGDEF domain
HB776_RS31160	COG2875	Belongs to the precorrin methyltransferase family
HB776_RS31170	COG0038	chloride channel
HB776_RS31195	COG2814	Major facilitator Superfamily
HB776_RS31205	COG1742	UPF0060 membrane protein
HB776_RS31210	COG0642	Histidine kinase
HB776_RS31235	COG4962	Type ii secretion system protein e
HB776_RS31240	COG3838	Conjugal transfer protein Trbc
HB776_RS31250	COG3451	type IV secretory pathway VirB4
HB776_RS31265	COG0477	Major facilitator Superfamily
HB776_RS31270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB776_RS31275	COG0583	DNA-binding transcription factor activity
HB776_RS31285	COG0477	Major facilitator Superfamily
HB776_RS31290	COG1942	4-Oxalocrotonate Tautomerase
HB776_RS31315	COG0604	alcohol dehydrogenase
HB776_RS31320	COG1309	transcriptional regulator
HB776_RS31340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB776_RS31345	COG0028	Belongs to the TPP enzyme family
HB776_RS31360	COG1396	sequence-specific DNA binding
HB776_RS31380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs