locus-tag	class	description
B6N58_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6N58_RS00030	COG0187	DNA topoisomerase II activity
B6N58_RS00045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6N58_RS00055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6N58_RS00060	COG1741	Belongs to the pirin family
B6N58_RS00065	COG0655	NAD(P)H dehydrogenase (quinone) activity
B6N58_RS00075	COG3028	Belongs to the UPF0307 family
B6N58_RS00090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6N58_RS00095	COG1472	Belongs to the glycosyl hydrolase 3 family
B6N58_RS00110	COG2818	Glycosylase
B6N58_RS00125	COG0531	amino acid
B6N58_RS00135	COG0306	phosphate transporter
B6N58_RS00140	COG1253	flavin adenine dinucleotide binding
B6N58_RS00185	COG0436	Aminotransferase
B6N58_RS00205	COG3079	Belongs to the UPF0149 family
B6N58_RS00215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6N58_RS00260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6N58_RS00270	COG1136	(ABC) transporter
B6N58_RS00270	COG0577	efflux transmembrane transporter activity
B6N58_RS00275	COG0656	L-ascorbic acid biosynthetic process
B6N58_RS00295	COG2824	Alkylphosphonate utilization operon protein PhnA
B6N58_RS00320	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B6N58_RS00360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B6N58_RS00380	COG1294	oxidase, subunit
B6N58_RS00385	COG1271	oxidase subunit
B6N58_RS00390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6N58_RS00425	COG0583	DNA-binding transcription factor activity
B6N58_RS00435	COG0671	phosphoesterase, PA-phosphatase related
B6N58_RS00440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6N58_RS00460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B6N58_RS00485	COG1475	DNA binding
B6N58_RS00490	COG1192	Involved in chromosome partitioning
B6N58_RS00495	COG0357	Ribosomal RNA small subunit methyltransferase G
B6N58_RS00525	COG2878	Part of a membrane complex involved in electron transport
B6N58_RS00530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B6N58_RS00555	COG0598	Magnesium transport protein CorA
B6N58_RS00565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6N58_RS00575	COG0252	asparaginase activity
B6N58_RS00585	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
B6N58_RS00590	COG0730	response to heat
B6N58_RS00595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B6N58_RS00600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B6N58_RS00615	COG1051	belongs to the nudix hydrolase family
B6N58_RS00620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B6N58_RS00635	COG1515	deoxyribonuclease V activity
B6N58_RS00640	COG0163	prenyltransferase activity
B6N58_RS00645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6N58_RS00670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B6N58_RS00680	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
B6N58_RS00690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B6N58_RS00705	COG1028	Short-chain dehydrogenase reductase Sdr
B6N58_RS00715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B6N58_RS00725	COG0714	Associated with various cellular activities
B6N58_RS00765	COG1278	Cold shock
B6N58_RS00780	COG1671	Belongs to the UPF0178 family
B6N58_RS00805	COG0516	GMP reductase activity
B6N58_RS00810	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B6N58_RS00815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B6N58_RS00830	COG2183	response to ionizing radiation
B6N58_RS00845	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6N58_RS00845	COG2918	glutathione biosynthetic process
B6N58_RS00880	COG0497	DNA recombination
B6N58_RS00895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B6N58_RS00900	COG1217	gtp-binding protein TYPA
B6N58_RS00910	COG1114	Component of the transport system for branched-chain amino acids
B6N58_RS00930	COG3135	benzoate transporter
B6N58_RS00960	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B6N58_RS00965	COG0210	DNA helicase
B6N58_RS01000	COG2719	SpoVR family
B6N58_RS01010	COG2766	serine protein kinase
B6N58_RS01015	COG0308	aminopeptidase N
B6N58_RS01040	COG3104	oligopeptide transport
B6N58_RS01050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B6N58_RS01080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B6N58_RS01115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6N58_RS01125	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B6N58_RS01130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B6N58_RS01135	COG1034	ATP synthesis coupled electron transport
B6N58_RS01185	COG2251	uridine kinase activity
B6N58_RS01185	COG0195	Participates in both transcription termination and antitermination
B6N58_RS01200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6N58_RS01220	COG0302	gtp cyclohydrolase
B6N58_RS01225	COG0537	adenosine 5'-monophosphoramidase activity
B6N58_RS01230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B6N58_RS01260	COG0439	Biotin carboxylase
B6N58_RS01280	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B6N58_RS01310	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B6N58_RS01330	COG2009	succinate dehydrogenase
B6N58_RS01335	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B6N58_RS01340	COG1053	succinate dehydrogenase
B6N58_RS01345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B6N58_RS01370	COG0300	oxidoreductase activity
B6N58_RS01415	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B6N58_RS01420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6N58_RS01435	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B6N58_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
B6N58_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
B6N58_RS01480	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
B6N58_RS01495	COG3243	poly(R)-hydroxyalkanoic acid synthase
B6N58_RS01505	COG1196	nuclear chromosome segregation
B6N58_RS01510	COG3115	cell septum assembly
B6N58_RS01515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6N58_RS01530	COG0772	Belongs to the SEDS family
B6N58_RS01585	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B6N58_RS01595	COG0546	phosphoglycolate phosphatase activity
B6N58_RS01610	COG0758	DNA mediated transformation
B6N58_RS01615	COG0242	peptide deformylase activity
B6N58_RS01620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6N58_RS01640	COG1475	DNA binding
B6N58_RS01645	COG2027	D-alanyl-D-alanine carboxypeptidase
B6N58_RS01670	COG1054	Belongs to the UPF0176 family
B6N58_RS01695	COG1960	acyl-CoA dehydrogenase activity
B6N58_RS01750	COG1064	alcohol dehydrogenase
B6N58_RS01755	COG0642	Histidine kinase
B6N58_RS01770	COG2271	Major facilitator Superfamily
B6N58_RS01775	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B6N58_RS01780	COG0735	belongs to the Fur family
B6N58_RS01800	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6N58_RS01800	COG2918	glutathione biosynthetic process
B6N58_RS01840	COG0708	Exodeoxyribonuclease III
B6N58_RS01855	COG0281	malic enzyme
B6N58_RS01860	COG2223	nitrite transmembrane transporter activity
B6N58_RS01870	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B6N58_RS01880	COG0814	amino acid
B6N58_RS01885	COG0814	amino acid
B6N58_RS01910	COG0700	Nucleoside recognition
B6N58_RS01920	COG0739	heme binding
B6N58_RS01950	COG1162	GTPase activity
B6N58_RS01965	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B6N58_RS01985	COG1959	2 iron, 2 sulfur cluster binding
B6N58_RS02015	COG0181	hydroxymethylbilane synthase activity
B6N58_RS02035	COG0784	Response regulator, receiver
B6N58_RS02050	COG2070	2-Nitropropane dioxygenase
B6N58_RS02070	COG0343	queuine tRNA-ribosyltransferase activity
B6N58_RS02075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B6N58_RS02080	COG2860	membrane
B6N58_RS02105	COG0477	Major facilitator Superfamily
B6N58_RS02155	COG0776	regulation of translation
B6N58_RS02170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B6N58_RS02175	COG0723	plastoquinol--plastocyanin reductase activity
B6N58_RS02185	COG2857	Cytochrome c1
B6N58_RS02190	COG0625	glutathione transferase activity
B6N58_RS02195	COG2969	positive regulation of protein catabolic process
B6N58_RS02200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B6N58_RS02200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B6N58_RS02205	COG0802	atpase or kinase
B6N58_RS02210	COG0860	N-Acetylmuramoyl-L-alanine amidase
B6N58_RS02215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B6N58_RS02245	COG2771	luxR family
B6N58_RS02265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B6N58_RS02265	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6N58_RS02280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B6N58_RS02280	COG0473	3-isopropylmalate dehydrogenase activity
B6N58_RS02285	COG0473	3-isopropylmalate dehydrogenase activity
B6N58_RS02285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B6N58_RS02305	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6N58_RS02305	COG2755	lipolytic protein G-D-S-L family
B6N58_RS02340	COG0386	Belongs to the glutathione peroxidase family
B6N58_RS02375	COG0742	ribosomal rna small subunit methyltransferase
B6N58_RS02380	COG0612	Peptidase, M16
B6N58_RS02385	COG0612	Peptidase, M16
B6N58_RS02390	COG0552	protein localization to endoplasmic reticulum
B6N58_RS02395	COG2884	Cell division ATP-binding protein ftsE
B6N58_RS02400	COG2177	Part of the ABC transporter FtsEX involved in
B6N58_RS02415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B6N58_RS02430	COG0745	RESPONSE REGULATOR receiver
B6N58_RS02440	COG0306	phosphate transporter
B6N58_RS02445	COG1392	Phosphate transport regulator
B6N58_RS02455	COG3243	poly(R)-hydroxyalkanoic acid synthase
B6N58_RS02485	COG0602	queuosine metabolic process
B6N58_RS02490	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B6N58_RS02495	COG2885	chlorophyll binding
B6N58_RS02500	COG3218	ABC-type transport auxiliary lipoprotein component
B6N58_RS02515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B6N58_RS02595	COG1064	alcohol dehydrogenase
B6N58_RS02605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B6N58_RS02700	COG0546	phosphoglycolate phosphatase activity
B6N58_RS02775	COG0494	nUDIX hydrolase
B6N58_RS02800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B6N58_RS02810	COG0425	Belongs to the sulfur carrier protein TusA family
B6N58_RS02815	COG0482	sulfurtransferase activity
B6N58_RS02830	COG0628	permease
B6N58_RS02870	COG2217	Heavy metal translocating P-type atpase
B6N58_RS02875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B6N58_RS02890	COG0429	hydrolase of the alpha beta-hydrolase fold
B6N58_RS02900	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B6N58_RS02930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B6N58_RS02940	COG2755	lipolytic protein G-D-S-L family
B6N58_RS02940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6N58_RS02945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6N58_RS02950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6N58_RS02965	COG0762	integral membrane protein
B6N58_RS02985	COG1561	YicC-like family, N-terminal region
B6N58_RS03000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6N58_RS03010	COG3577	Aspartyl protease
B6N58_RS03015	COG0488	(ABC) transporter
B6N58_RS03040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6N58_RS03095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B6N58_RS03120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B6N58_RS03140	COG0572	uridine kinase
B6N58_RS03150	COG2890	protein-(glutamine-N5) methyltransferase activity
B6N58_RS03160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B6N58_RS03190	COG1530	ribonuclease E activity
B6N58_RS03195	COG0564	pseudouridine synthase activity
B6N58_RS03200	COG0546	phosphoglycolate phosphatase activity
B6N58_RS03225	COG0582	viral genome integration into host DNA
B6N58_RS03305	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B6N58_RS03310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B6N58_RS03315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B6N58_RS03330	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
B6N58_RS03355	COG0189	ligase activity
B6N58_RS03400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B6N58_RS03405	COG2853	Lipoprotein
B6N58_RS03420	COG0583	DNA-binding transcription factor activity
B6N58_RS03425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B6N58_RS03440	COG0069	glutamate synthase activity
B6N58_RS03450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B6N58_RS03500	COG0606	chelatase, subunit chli
B6N58_RS03505	COG2960	long-chain fatty acid transporting porin activity
B6N58_RS03520	COG0347	Belongs to the P(II) protein family
B6N58_RS03530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B6N58_RS03545	COG0398	Pfam SNARE associated Golgi protein
B6N58_RS03550	COG0318	PFAM AMP-dependent synthetase and ligase
B6N58_RS03550	COG0204	Acyl-transferase
B6N58_RS03660	COG0450	alkyl hydroperoxide reductase
B6N58_RS03690	COG0513	Belongs to the DEAD box helicase family
B6N58_RS03715	COG3240	lipase activity
B6N58_RS03725	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B6N58_RS03730	COG1519	Transferase
B6N58_RS03735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B6N58_RS03740	COG2890	protein-(glutamine-N5) methyltransferase activity
B6N58_RS03760	COG0750	zinc metalloprotease
B6N58_RS03765	COG1040	competence protein
B6N58_RS03770	COG2226	methyltransferase
B6N58_RS03775	COG2027	D-alanyl-D-alanine carboxypeptidase
B6N58_RS03785	COG2197	response regulator
B6N58_RS03790	COG0322	excinuclease ABC activity
B6N58_RS03880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B6N58_RS03895	COG0659	secondary active sulfate transmembrane transporter activity
B6N58_RS03905	COG1538	Outer membrane efflux protein
B6N58_RS03910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6N58_RS03915	COG0156	8-amino-7-oxononanoate synthase activity
B6N58_RS03925	COG0488	(ABC) transporter
B6N58_RS03960	COG1297	OPT oligopeptide transporter protein
B6N58_RS03965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6N58_RS03975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6N58_RS03980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6N58_RS04005	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B6N58_RS04010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B6N58_RS04015	COG0628	permease
B6N58_RS04030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6N58_RS04040	COG2267	carboxylic ester hydrolase activity
B6N58_RS04075	COG0477	Major facilitator Superfamily
B6N58_RS04100	COG0205	6-phosphofructokinase activity
B6N58_RS04115	COG0745	RESPONSE REGULATOR receiver
B6N58_RS04120	COG0784	Response regulator, receiver
B6N58_RS04120	COG2205	protein histidine kinase activity
B6N58_RS04140	COG3774	pathogenesis
B6N58_RS04160	COG0783	Belongs to the Dps family
B6N58_RS04205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6N58_RS04240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B6N58_RS04305	COG1776	CheC inhibitor of MCP methylation
B6N58_RS04305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B6N58_RS04320	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B6N58_RS04335	COG1157	protein secretion by the type III secretion system
B6N58_RS04350	COG1766	The M ring may be actively involved in energy transduction
B6N58_RS04355	COG1677	Flagellar hook-basal body complex protein FliE
B6N58_RS04370	COG1706	bacterial-type flagellum-dependent cell motility
B6N58_RS04375	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B6N58_RS04385	COG4786	Flagellar basal body rod
B6N58_RS04390	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B6N58_RS04395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B6N58_RS04410	COG3012	SEC-C Motif Domain Protein
B6N58_RS04485	COG2951	lytic endotransglycosylase activity
B6N58_RS04495	COG0681	Belongs to the peptidase S26 family
B6N58_RS04500	COG0571	ribonuclease III activity
B6N58_RS04505	COG0488	(ABC) transporter
B6N58_RS04515	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B6N58_RS04520	COG0343	queuine tRNA-ribosyltransferase activity
B6N58_RS04525	COG1862	Preprotein translocase
B6N58_RS04530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6N58_RS04535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6N58_RS04615	COG3655	Transcriptional regulator
B6N58_RS04690	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B6N58_RS04705	COG1301	dicarboxylic acid transport
B6N58_RS04730	COG2274	protein secretion by the type I secretion system
B6N58_RS04735	COG0583	DNA-binding transcription factor activity
B6N58_RS04740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6N58_RS04765	COG0415	Belongs to the DNA photolyase family
B6N58_RS04775	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B6N58_RS04780	COG2814	Major facilitator Superfamily
B6N58_RS04785	COG0531	amino acid
B6N58_RS04800	COG0668	transmembrane transport
B6N58_RS04805	COG0121	glutamine amidotransferase
B6N58_RS04810	COG0069	glutamate synthase activity
B6N58_RS04820	COG3848	Pyruvate phosphate dikinase
B6N58_RS04820	COG0574	Belongs to the PEP-utilizing enzyme family
B6N58_RS04840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6N58_RS04890	COG2274	protein secretion by the type I secretion system
B6N58_RS04945	COG2409	Drug exporters of the RND superfamily
B6N58_RS04970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6N58_RS04980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B6N58_RS05010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B6N58_RS05075	COG2205	protein histidine kinase activity
B6N58_RS05090	COG3328	transposase activity
B6N58_RS05115	COG0629	single-stranded DNA binding
B6N58_RS05190	COG2313	pseudouridylate synthase activity
B6N58_RS05215	COG2502	aspartate--ammonia ligase
B6N58_RS05220	COG1522	sequence-specific DNA binding
B6N58_RS05230	COG4591	ABC-type transport system involved in lipoprotein release permease component
B6N58_RS05235	COG1136	(ABC) transporter
B6N58_RS05255	COG0625	glutathione transferase activity
B6N58_RS05285	COG0584	glycerophosphoryl diester phosphodiesterase
B6N58_RS05290	COG1653	transport
B6N58_RS05300	COG0494	nUDIX hydrolase
B6N58_RS05320	COG0741	lytic transglycosylase activity
B6N58_RS05325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B6N58_RS05410	COG3104	oligopeptide transport
B6N58_RS05445	COG0463	Glycosyl transferase, family 2
B6N58_RS05465	COG2084	Dehydrogenase
B6N58_RS05510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6N58_RS05520	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B6N58_RS05520	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B6N58_RS05540	COG0037	tRNA processing
B6N58_RS05555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6N58_RS05560	COG2814	Major facilitator Superfamily
B6N58_RS05565	COG1760	l-serine dehydratase
B6N58_RS05575	COG2223	nitrite transmembrane transporter activity
B6N58_RS05615	COG0531	amino acid
B6N58_RS05620	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B6N58_RS05625	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B6N58_RS05635	COG1538	Outer membrane efflux protein
B6N58_RS05640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6N58_RS05660	COG0463	Glycosyl transferase, family 2
B6N58_RS05665	COG0574	Belongs to the PEP-utilizing enzyme family
B6N58_RS05665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6N58_RS05670	COG0475	glutathione-regulated potassium exporter activity
B6N58_RS05685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6N58_RS05695	COG1077	Cell shape determining protein MreB Mrl
B6N58_RS05700	COG1792	Involved in formation and maintenance of cell shape
B6N58_RS05710	COG1187	pseudouridine synthase activity
B6N58_RS05725	COG0542	response to heat
B6N58_RS05755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B6N58_RS05760	COG1177	transmembrane transport
B6N58_RS05765	COG1176	ABC-type spermidine putrescine transport system, permease component I
B6N58_RS05770	COG3842	ATPase activity
B6N58_RS05790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6N58_RS05800	COG0601	transmembrane transport
B6N58_RS05805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6N58_RS05820	COG2771	luxR family
B6N58_RS05845	COG0616	signal peptide processing
B6N58_RS05865	COG2814	Major facilitator Superfamily
B6N58_RS05870	COG1566	PFAM secretion protein HlyD family protein
B6N58_RS05895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B6N58_RS05910	COG1138	Cytochrome C-type biogenesis protein
B6N58_RS05935	COG3360	Dodecin
B6N58_RS05950	COG1024	Enoyl-CoA hydratase
B6N58_RS05955	COG1024	Enoyl-CoA hydratase
B6N58_RS06070	COG0583	DNA-binding transcription factor activity
B6N58_RS06075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B6N58_RS06090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B6N58_RS06150	COG0693	protein deglycase activity
B6N58_RS06155	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B6N58_RS06200	COG2271	Major facilitator Superfamily
B6N58_RS06220	COG5654	RES domain protein
B6N58_RS06225	COG5642	Protein of unknown function (DUF2384)
B6N58_RS06230	COG4783	chaperone-mediated protein folding
B6N58_RS06245	COG0307	riboflavin synthase, alpha
B6N58_RS06250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6N58_RS06250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6N58_RS06280	COG2974	May be involved in recombination
B6N58_RS06290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B6N58_RS06290	COG0140	phosphoribosyl-ATP diphosphatase activity
B6N58_RS06305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B6N58_RS06320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B6N58_RS06325	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B6N58_RS06335	COG1335	isochorismatase
B6N58_RS06355	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
B6N58_RS06365	COG3245	cytochrome
B6N58_RS06395	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6N58_RS06405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6N58_RS06405	COG0512	Glutamine amidotransferase of anthranilate synthase
B6N58_RS06410	COG0038	chloride channel
B6N58_RS06430	COG0604	alcohol dehydrogenase
B6N58_RS06440	COG0395	ABC-type sugar transport system, permease component
B6N58_RS06445	COG3842	ATPase activity
B6N58_RS06460	COG1960	acyl-CoA dehydrogenase activity
B6N58_RS06470	COG2894	cell division
B6N58_RS06520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B6N58_RS06520	COG4651	solute:proton antiporter activity
B6N58_RS06560	COG3138	arginine N-succinyltransferase
B6N58_RS06575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B6N58_RS06610	COG2353	YceI-like domain
B6N58_RS06630	COG0531	amino acid
B6N58_RS06635	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B6N58_RS06645	COG3144	bacterial-type flagellum assembly
B6N58_RS06655	COG2850	peptidyl-arginine hydroxylation
B6N58_RS06675	COG1234	tRNA 3'-trailer cleavage
B6N58_RS06685	COG0814	amino acid
B6N58_RS06715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B6N58_RS06740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6N58_RS06800	COG1496	oxidoreductase activity
B6N58_RS06805	COG0564	pseudouridine synthase activity
B6N58_RS06815	COG2271	Major facilitator Superfamily
B6N58_RS06820	COG1271	oxidase subunit
B6N58_RS06825	COG1294	oxidase, subunit
B6N58_RS06845	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6N58_RS06850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6N58_RS06880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6N58_RS06890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6N58_RS06900	COG0372	Belongs to the citrate synthase family
B6N58_RS06915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6N58_RS06920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B6N58_RS06925	COG0539	negative regulation of cytoplasmic translation
B6N58_RS06935	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B6N58_RS06950	COG1573	uracil-dna glycosylase
B6N58_RS06970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6N58_RS06990	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B6N58_RS06995	COG0295	cytidine deaminase activity
B6N58_RS07015	COG2205	protein histidine kinase activity
B6N58_RS07020	COG0745	RESPONSE REGULATOR receiver
B6N58_RS07035	COG1702	phosphate starvation-inducible protein PhoH
B6N58_RS07045	COG2986	histidine ammonia-lyase
B6N58_RS07050	COG0613	PHP domain protein
B6N58_RS07055	COG0009	L-threonylcarbamoyladenylate synthase
B6N58_RS07060	COG0180	Tryptophanyl-tRNA synthetase
B6N58_RS07065	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B6N58_RS07070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B6N58_RS07075	COG1187	pseudouridine synthase activity
B6N58_RS07090	COG1028	Short-chain dehydrogenase reductase Sdr
B6N58_RS07120	COG2165	general secretion pathway protein
B6N58_RS07135	COG0174	glutamine synthetase
B6N58_RS07150	COG3328	transposase activity
B6N58_RS07155	COG3781	membrane
B6N58_RS07165	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B6N58_RS07170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6N58_RS07175	COG0673	inositol 2-dehydrogenase activity
B6N58_RS07190	COG0772	Belongs to the SEDS family
B6N58_RS07230	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B6N58_RS07240	COG1028	Short-chain dehydrogenase reductase Sdr
B6N58_RS07285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6N58_RS07290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B6N58_RS07305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6N58_RS07310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B6N58_RS07330	COG0084	hydrolase, TatD family'
B6N58_RS07360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6N58_RS07360	COG2169	Transcriptional regulator
B6N58_RS07380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B6N58_RS07385	COG2224	Isocitrate lyase
B6N58_RS07445	COG2423	ornithine cyclodeaminase activity
B6N58_RS07460	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B6N58_RS07480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6N58_RS07480	COG2755	lipolytic protein G-D-S-L family
B6N58_RS07495	COG0183	Belongs to the thiolase family
B6N58_RS07510	COG3083	sulfuric ester hydrolase activity
B6N58_RS07515	COG0259	pyridoxamine-phosphate oxidase activity
B6N58_RS07520	COG4221	oxidoreductase activity
B6N58_RS07615	COG0156	8-amino-7-oxononanoate synthase activity
B6N58_RS07630	COG2200	EAL domain
B6N58_RS07665	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B6N58_RS07695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B6N58_RS07700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B6N58_RS07710	COG0436	Aminotransferase
B6N58_RS07730	COG3791	Glutathione-dependent formaldehyde-activating
B6N58_RS07735	COG4953	penicillin-binding protein 1C
B6N58_RS07740	COG2373	Large extracellular alpha-helical protein
B6N58_RS07745	COG1983	PspC domain protein
B6N58_RS07755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6N58_RS07785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B6N58_RS07800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6N58_RS07805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6N58_RS07815	COG0183	Belongs to the thiolase family
B6N58_RS07820	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6N58_RS07820	COG1024	Enoyl-CoA hydratase
B6N58_RS07825	COG1012	belongs to the aldehyde dehydrogenase family
B6N58_RS07835	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B6N58_RS07845	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
B6N58_RS07855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B6N58_RS07865	COG1286	toxin biosynthetic process
B6N58_RS07875	COG0285	dihydrofolate synthase activity
B6N58_RS07915	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B6N58_RS07925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B6N58_RS07930	COG2921	Belongs to the UPF0250 family
B6N58_RS07940	COG0586	Pfam SNARE associated Golgi protein
B6N58_RS07960	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B6N58_RS07975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B6N58_RS07985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B6N58_RS08015	COG2079	MmgE PrpD family protein
B6N58_RS08020	COG0372	Belongs to the citrate synthase family
B6N58_RS08025	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B6N58_RS08045	COG0280	phosphate acetyltransferase
B6N58_RS08045	COG0857	belongs to the CobB CobQ family
B6N58_RS08055	COG0861	Integral membrane protein TerC family
B6N58_RS08060	COG1981	membrane
B6N58_RS08075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6N58_RS08080	COG0617	tRNA 3'-terminal CCA addition
B6N58_RS08105	COG2976	Protein conserved in bacteria
B6N58_RS08115	COG1426	Protein conserved in bacteria
B6N58_RS08155	COG0850	regulation of cytokinetic process
B6N58_RS08160	COG0318	PFAM AMP-dependent synthetase and ligase
B6N58_RS08200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B6N58_RS08230	COG0824	Thioesterase
B6N58_RS08235	COG2255	four-way junction helicase activity
B6N58_RS08255	COG3038	cytochrome b561
B6N58_RS08270	COG1012	belongs to the aldehyde dehydrogenase family
B6N58_RS08275	COG1183	phosphatidylcholine synthase activity
B6N58_RS08325	COG1376	ErfK ybiS ycfS ynhG family protein
B6N58_RS08330	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6N58_RS08330	COG1024	Enoyl-CoA hydratase
B6N58_RS08335	COG0183	Belongs to the thiolase family
B6N58_RS08340	COG0288	reversible hydration of carbon dioxide
B6N58_RS08385	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
B6N58_RS08400	COG0309	Hydrogenase expression formation protein (HypE)
B6N58_RS08415	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B6N58_RS08440	COG2217	Heavy metal translocating P-type atpase
B6N58_RS08445	COG0589	response to stress
B6N58_RS08450	COG0589	response to stress
B6N58_RS08470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6N58_RS08470	COG1042	CoA-binding domain protein
B6N58_RS08470	COG0045	succinate-CoA ligase (ADP-forming) activity
B6N58_RS08485	COG0745	RESPONSE REGULATOR receiver
B6N58_RS08500	COG0789	Transcriptional regulator
B6N58_RS08505	COG1132	(ABC) transporter
B6N58_RS08510	COG0488	(ABC) transporter
B6N58_RS08515	COG3693	PFAM glycoside hydrolase, family 10
B6N58_RS08515	COG3507	Belongs to the glycosyl hydrolase 43 family
B6N58_RS08515	COG2382	esterase
B6N58_RS08525	COG1280	lysine exporter protein (LysE YggA)
B6N58_RS08545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6N58_RS08580	COG3328	transposase activity
B6N58_RS08610	COG5310	Homospermidine synthase
B6N58_RS08615	COG2270	Major facilitator Superfamily
B6N58_RS08630	COG2409	Drug exporters of the RND superfamily
B6N58_RS08650	COG2271	Major facilitator Superfamily
B6N58_RS08675	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B6N58_RS08685	COG1388	LysM domain
B6N58_RS08685	COG0741	lytic transglycosylase activity
B6N58_RS08690	COG2198	Histidine kinase
B6N58_RS08690	COG5002	protein histidine kinase activity
B6N58_RS08690	COG0784	Response regulator, receiver
B6N58_RS08700	COG2917	probably involved in intracellular septation
B6N58_RS08725	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B6N58_RS08730	COG0217	transcriptional regulatory protein
B6N58_RS08735	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B6N58_RS08740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6N58_RS08765	COG0281	malic enzyme
B6N58_RS08775	COG2378	regulation of single-species biofilm formation
B6N58_RS08790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6N58_RS08805	COG1376	ErfK ybiS ycfS ynhG family protein
B6N58_RS08835	COG0604	alcohol dehydrogenase
B6N58_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
B6N58_RS08935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6N58_RS08935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6N58_RS08935	COG3321	synthase
B6N58_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
B6N58_RS08935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6N58_RS08975	COG0288	reversible hydration of carbon dioxide
B6N58_RS08990	COG1846	Transcriptional regulator
B6N58_RS09000	COG1256	bacterial-type flagellum assembly
B6N58_RS09000	COG4786	Flagellar basal body rod
B6N58_RS09005	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6N58_RS09005	COG3951	Flagellar rod assembly protein muramidase FlgJ
B6N58_RS09030	COG1749	Flagellar hook protein flgE
B6N58_RS09035	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B6N58_RS09040	COG1558	bacterial-type flagellum-dependent cell motility
B6N58_RS09045	COG1815	bacterial-type flagellum-dependent cell motility
B6N58_RS09055	COG0477	Major facilitator Superfamily
B6N58_RS09080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6N58_RS09135	COG2867	negative regulation of translational initiation
B6N58_RS09135	COG2226	methyltransferase
B6N58_RS09160	COG5001	Diguanylate cyclase
B6N58_RS09160	COG3300	MHYT domain
B6N58_RS09165	COG0626	cystathionine gamma-synthase activity
B6N58_RS09170	COG0204	Acyl-transferase
B6N58_RS09210	COG1472	Belongs to the glycosyl hydrolase 3 family
B6N58_RS09225	COG0300	oxidoreductase activity
B6N58_RS09230	COG0667	Aldo Keto reductase
B6N58_RS09245	COG0756	dUTP diphosphatase activity
B6N58_RS09265	COG0833	amino acid
B6N58_RS09280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6N58_RS09305	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B6N58_RS09330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B6N58_RS09335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B6N58_RS09340	COG1127	ABC transporter
B6N58_RS09350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B6N58_RS09365	COG1137	ATPase activity
B6N58_RS09385	COG2066	Belongs to the glutaminase family
B6N58_RS09410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B6N58_RS09415	COG0312	modulator of DNA gyrase
B6N58_RS09420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6N58_RS09425	COG0670	Belongs to the BI1 family
B6N58_RS09450	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6N58_RS09455	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B6N58_RS09455	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6N58_RS09490	COG0800	Aldolase
B6N58_RS09495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B6N58_RS09505	COG0196	riboflavin kinase activity
B6N58_RS09510	COG1872	DUF167
B6N58_RS09515	COG0025	NhaP-type Na H and K H
B6N58_RS09525	COG2814	Major facilitator Superfamily
B6N58_RS09540	COG2340	Cysteine-rich secretory protein family
B6N58_RS09565	COG0589	response to stress
B6N58_RS09570	COG0589	response to stress
B6N58_RS09585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B6N58_RS09640	COG0686	Belongs to the AlaDH PNT family
B6N58_RS09655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6N58_RS09675	COG0463	Glycosyl transferase, family 2
B6N58_RS09685	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B6N58_RS09690	COG1994	Peptidase M50
B6N58_RS09700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B6N58_RS09740	COG0316	Belongs to the HesB IscA family
B6N58_RS09755	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B6N58_RS09765	COG0697	spore germination
B6N58_RS09780	COG0542	response to heat
B6N58_RS09800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B6N58_RS09845	COG1677	Flagellar hook-basal body complex protein FliE
B6N58_RS09880	COG0586	Pfam SNARE associated Golgi protein
B6N58_RS09900	COG1674	ftsk spoiiie
B6N58_RS09905	COG0492	ferredoxin-NADP+ reductase activity
B6N58_RS09920	COG0312	modulator of DNA gyrase
B6N58_RS09930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6N58_RS09930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B6N58_RS09970	COG3328	transposase activity
B6N58_RS09980	COG1360	Flagellar Motor Protein
B6N58_RS09985	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B6N58_RS10015	COG1684	flagellar biosynthetic protein fliR
B6N58_RS10020	COG1987	bacterial-type flagellum assembly
B6N58_RS10030	COG3190	flagellar
B6N58_RS10045	COG0277	FAD linked oxidase domain protein
B6N58_RS10075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6N58_RS10085	COG2274	protein secretion by the type I secretion system
B6N58_RS10100	COG2132	Multicopper oxidase
B6N58_RS10105	COG2267	carboxylic ester hydrolase activity
B6N58_RS10125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B6N58_RS10165	COG0438	transferase activity, transferring glycosyl groups
B6N58_RS10175	COG1201	RNA secondary structure unwinding
B6N58_RS10215	COG1546	Belongs to the CinA family
B6N58_RS10225	COG0729	surface antigen
B6N58_RS10235	COG0113	porphobilinogen synthase activity
B6N58_RS10250	COG0527	aspartate kinase activity
B6N58_RS10255	COG1074	ATP-dependent DNA helicase activity
B6N58_RS10260	COG0489	protein tyrosine kinase activity
B6N58_RS10265	COG0187	DNA topoisomerase II activity
B6N58_RS10270	COG0667	Aldo Keto reductase
B6N58_RS10340	COG4969	Belongs to the N-Me-Phe pilin family
B6N58_RS10350	COG0271	Belongs to the BolA IbaG family
B6N58_RS10360	COG0531	amino acid
B6N58_RS10380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B6N58_RS10390	COG1214	PFAM Peptidase M22, glycoprotease
B6N58_RS10395	COG1199	ATP-dependent helicase activity
B6N58_RS10400	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B6N58_RS10405	COG0435	Glutathione S-transferase
B6N58_RS10430	COG1028	Short-chain dehydrogenase reductase Sdr
B6N58_RS10435	COG4689	acetoacetate decarboxylase
B6N58_RS10480	COG1090	epimerase
B6N58_RS10505	COG2151	metal-sulfur cluster biosynthetic enzyme
B6N58_RS10520	COG0719	Fe-S assembly protein
B6N58_RS10525	COG0396	ATPase activity
B6N58_RS10530	COG0719	Fe-S assembly protein
B6N58_RS10535	COG1959	2 iron, 2 sulfur cluster binding
B6N58_RS10560	COG0795	lipopolysaccharide-transporting ATPase activity
B6N58_RS10565	COG0795	lipopolysaccharide-transporting ATPase activity
B6N58_RS10575	COG2927	DNA polymerase III (CHI subunit)
B6N58_RS10585	COG0728	peptidoglycan biosynthetic process
B6N58_RS10625	COG1132	(ABC) transporter
B6N58_RS10645	COG1960	acyl-CoA dehydrogenase activity
B6N58_RS10660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6N58_RS10695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6N58_RS10720	COG2011	ABC-type metal ion transport system permease component
B6N58_RS10725	COG1464	Belongs to the NlpA lipoprotein family
B6N58_RS10765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B6N58_RS10770	COG0751	glycine-tRNA ligase activity
B6N58_RS10785	COG0210	DNA helicase
B6N58_RS10790	COG1278	Cold shock
B6N58_RS10795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B6N58_RS10865	COG1612	heme a metabolic process
B6N58_RS10885	COG0625	glutathione transferase activity
B6N58_RS10905	COG3220	belongs to the UPF0276 family
B6N58_RS10915	COG3038	cytochrome b561
B6N58_RS10925	COG0427	acetyl-CoA hydrolase
B6N58_RS10930	COG2301	Belongs to the HpcH HpaI aldolase family
B6N58_RS10935	COG2030	dehydratase
B6N58_RS10960	COG0789	Transcriptional regulator
B6N58_RS10970	COG2852	Protein conserved in bacteria
B6N58_RS10985	COG3706	GGDEF domain
B6N58_RS10990	COG3706	GGDEF domain
B6N58_RS11010	COG0784	Response regulator, receiver
B6N58_RS11010	COG5002	protein histidine kinase activity
B6N58_RS11010	COG2198	Histidine kinase
B6N58_RS11020	COG1881	PFAM PEBP family protein
B6N58_RS11050	COG1566	PFAM secretion protein HlyD family protein
B6N58_RS11055	COG0477	Major facilitator Superfamily
B6N58_RS11060	COG0038	chloride channel
B6N58_RS11065	COG1301	dicarboxylic acid transport
B6N58_RS11070	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B6N58_RS11075	COG0300	oxidoreductase activity
B6N58_RS11115	COG0142	geranyltranstransferase activity
B6N58_RS11120	COG0668	transmembrane transport
B6N58_RS11130	COG1546	Belongs to the CinA family
B6N58_RS11130	COG1058	Belongs to the CinA family
B6N58_RS11135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6N58_RS11160	COG0012	GTP binding
B6N58_RS11170	COG5001	Diguanylate cyclase
B6N58_RS11170	COG3300	MHYT domain
B6N58_RS11175	COG0142	geranyltranstransferase activity
B6N58_RS11210	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6N58_RS11215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6N58_RS11220	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6N58_RS11255	COG4942	peptidase
B6N58_RS11260	COG0793	Belongs to the peptidase S41A family
B6N58_RS11285	COG0330	HflC and HflK could
B6N58_RS11290	COG0330	HflC and HflK could
B6N58_RS11315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B6N58_RS11325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6N58_RS11330	COG0277	FAD linked oxidase domain protein
B6N58_RS11345	COG1183	phosphatidylcholine synthase activity
B6N58_RS11360	COG0633	Ferredoxin
B6N58_RS11360	COG0543	2 iron, 2 sulfur cluster binding
B6N58_RS11365	COG3588	fructose-bisphosphate aldolase
B6N58_RS11370	COG3568	Endonuclease Exonuclease Phosphatase
B6N58_RS11375	COG1404	Belongs to the peptidase S8 family
B6N58_RS11385	COG3227	Zinc metalloprotease (Elastase)
B6N58_RS11390	COG0009	L-threonylcarbamoyladenylate synthase
B6N58_RS11395	COG5016	pyruvate
B6N58_RS11395	COG0511	ligase activity, forming carbon-carbon bonds
B6N58_RS11405	COG0511	ligase activity, forming carbon-carbon bonds
B6N58_RS11410	COG0439	Biotin carboxylase
B6N58_RS11415	COG2264	protein methyltransferase activity
B6N58_RS11420	COG0138	bifunctional purine biosynthesis protein purh
B6N58_RS11430	COG2217	Heavy metal translocating P-type atpase
B6N58_RS11465	COG0494	nUDIX hydrolase
B6N58_RS11470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B6N58_RS11495	COG0358	DNA primase activity
B6N58_RS11575	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B6N58_RS11710	COG0629	single-stranded DNA binding
B6N58_RS11735	COG2963	transposase activity
B6N58_RS11775	COG2081	HI0933 family
B6N58_RS11850	COG0745	RESPONSE REGULATOR receiver
B6N58_RS11900	COG0513	Belongs to the DEAD box helicase family
B6N58_RS11940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6N58_RS11960	COG0531	amino acid
B6N58_RS11965	COG0590	tRNA wobble adenosine to inosine editing
B6N58_RS11995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6N58_RS12020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6N58_RS12035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6N58_RS12050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6N58_RS12060	COG4221	oxidoreductase activity
B6N58_RS12115	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B6N58_RS12120	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B6N58_RS12120	COG0456	acetyltransferase
B6N58_RS12130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6N58_RS12150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6N58_RS12155	COG0756	dUTP diphosphatase activity
B6N58_RS12160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B6N58_RS12200	COG1902	pentaerythritol trinitrate reductase activity
B6N58_RS12210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6N58_RS12215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6N58_RS12235	COG0151	Belongs to the GarS family
B6N58_RS12240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B6N58_RS12250	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B6N58_RS12275	COG3475	LICD family
B6N58_RS12280	COG1850	ribulose-bisphosphate carboxylase activity
B6N58_RS12295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B6N58_RS12315	COG0842	Transport permease protein
B6N58_RS12320	COG1131	(ABC) transporter
B6N58_RS12330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6N58_RS12335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B6N58_RS12385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B6N58_RS12390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B6N58_RS12430	COG4536	flavin adenine dinucleotide binding
B6N58_RS12435	COG0572	uridine kinase
B6N58_RS12440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6N58_RS12455	COG0336	Belongs to the RNA methyltransferase TrmD family
B6N58_RS12485	COG1131	(ABC) transporter
B6N58_RS12490	COG0842	Transport permease protein
B6N58_RS12520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6N58_RS12525	COG0765	amino acid transport
B6N58_RS12530	COG1126	abc transporter atp-binding protein
B6N58_RS12535	COG0137	argininosuccinate synthase activity
B6N58_RS12540	COG0165	Argininosuccinate lyase
B6N58_RS12545	COG0505	Belongs to the CarA family
B6N58_RS12600	COG1704	LemA family
B6N58_RS12610	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B6N58_RS12615	COG0352	thiamine-phosphate diphosphorylase activity
B6N58_RS12620	COG0745	RESPONSE REGULATOR receiver
B6N58_RS12675	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B6N58_RS12695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6N58_RS12730	COG0494	nUDIX hydrolase
B6N58_RS12740	COG1346	cytolysis
B6N58_RS12745	COG1380	Effector of murein hydrolase LrgA
B6N58_RS12750	COG0583	DNA-binding transcription factor activity
B6N58_RS12765	COG1028	Short-chain dehydrogenase reductase Sdr
B6N58_RS12770	COG2205	protein histidine kinase activity
B6N58_RS12770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6N58_RS12780	COG2205	protein histidine kinase activity
B6N58_RS12780	COG0784	Response regulator, receiver
B6N58_RS12815	COG0433	COG0433 Predicted ATPase
B6N58_RS12820	COG0735	belongs to the Fur family
B6N58_RS12825	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6N58_RS12830	COG1335	isochorismatase
B6N58_RS12835	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B6N58_RS12845	COG2867	negative regulation of translational initiation
B6N58_RS12850	COG0400	carboxylic ester hydrolase activity
B6N58_RS12870	COG0569	domain protein
B6N58_RS12875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B6N58_RS12890	COG4232	protein-disulfide reductase activity
B6N58_RS12895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6N58_RS12910	COG1560	Kdo2-lipid A biosynthetic process
B6N58_RS12915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6N58_RS12920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6N58_RS12925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6N58_RS12935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6N58_RS12965	COG1028	Short-chain dehydrogenase reductase Sdr
B6N58_RS12970	COG2814	Major facilitator Superfamily
B6N58_RS12975	COG0629	single-stranded DNA binding
B6N58_RS13010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B6N58_RS13155	COG0222	ribosome binding
B6N58_RS13250	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B6N58_RS13260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6N58_RS13290	COG1509	lysine 2,3-aminomutase activity
B6N58_RS13295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6N58_RS13330	COG3101	peptidyl-lysine hydroxylation
B6N58_RS13340	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B6N58_RS13390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6N58_RS13410	COG2226	methyltransferase
B6N58_RS13420	COG3527	Alpha-acetolactate decarboxylase
B6N58_RS13425	COG0028	Belongs to the TPP enzyme family
B6N58_RS13430	COG1028	Short-chain dehydrogenase reductase Sdr
B6N58_RS13435	COG3046	protein related to deoxyribodipyrimidine photolyase
B6N58_RS13455	COG1289	transmembrane transporter activity
B6N58_RS13480	COG2205	protein histidine kinase activity
B6N58_RS13480	COG2198	Histidine kinase
B6N58_RS13480	COG0784	Response regulator, receiver
B6N58_RS13525	COG0732	type I restriction modification DNA specificity domain
B6N58_RS13530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B6N58_RS13535	COG3328	transposase activity
B6N58_RS13545	COG3586	endonuclease activity
B6N58_RS13555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B6N58_RS13560	COG0732	type I restriction modification DNA specificity domain
B6N58_RS13565	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B6N58_RS13590	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B6N58_RS13635	COG2948	multi-organism process
B6N58_RS13655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6N58_RS13710	COG0582	viral genome integration into host DNA
B6N58_RS13725	COG0339	signal peptide processing
B6N58_RS13735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B6N58_RS13740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B6N58_RS13750	COG0469	pyruvate kinase activity
B6N58_RS13760	COG1116	anion transmembrane transporter activity
B6N58_RS13800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6N58_RS13815	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B6N58_RS13830	COG2252	PERMEase
B6N58_RS13845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6N58_RS13860	COG3590	peptidase
B6N58_RS13890	COG0114	fumarate hydratase activity
B6N58_RS13900	COG1304	FMN binding
B6N58_RS13915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B6N58_RS13935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B6N58_RS13950	COG1125	glycine betaine transport
B6N58_RS13950	COG0517	IMP dehydrogenase activity
B6N58_RS13955	COG1174	glycine betaine transport
B6N58_RS13960	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6N58_RS14000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6N58_RS14005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6N58_RS14035	COG0776	regulation of translation
B6N58_RS14045	COG0330	HflC and HflK could
B6N58_RS14070	COG2885	chlorophyll binding
B6N58_RS14080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6N58_RS14085	COG0450	alkyl hydroperoxide reductase
B6N58_RS14090	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B6N58_RS14095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B6N58_RS14100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6N58_RS14105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6N58_RS14110	COG0557	exoribonuclease II activity
B6N58_RS14155	COG0189	ligase activity
B6N58_RS14155	COG4067	protein conserved in archaea
B6N58_RS14200	COG2226	methyltransferase
B6N58_RS14235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B6N58_RS14255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6N58_RS14260	COG0784	Response regulator, receiver
B6N58_RS14260	COG2205	protein histidine kinase activity
B6N58_RS14260	COG5002	protein histidine kinase activity
B6N58_RS14265	COG0805	protein transport
B6N58_RS14280	COG4106	trans-aconitate 2-methyltransferase activity
B6N58_RS14285	COG1215	transferase activity, transferring glycosyl groups
B6N58_RS14300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6N58_RS14310	COG0463	Glycosyl transferase, family 2
B6N58_RS14325	COG0028	Belongs to the TPP enzyme family
B6N58_RS14350	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
B6N58_RS14390	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B6N58_RS14395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6N58_RS14420	COG0543	2 iron, 2 sulfur cluster binding
B6N58_RS14420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B6N58_RS14440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B6N58_RS14555	COG2823	Periplasmic or secreted lipoprotein
B6N58_RS14560	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B6N58_RS14565	COG0792	nuclease activity
B6N58_RS14570	COG3107	peptidoglycan biosynthetic process
B6N58_RS14575	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA