locus-tag	class	description
B6V88_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6V88_RS00030	COG0187	DNA topoisomerase II activity
B6V88_RS00045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6V88_RS00055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6V88_RS00060	COG1741	Belongs to the pirin family
B6V88_RS00065	COG0655	NAD(P)H dehydrogenase (quinone) activity
B6V88_RS00075	COG3028	Belongs to the UPF0307 family
B6V88_RS00090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6V88_RS00095	COG1472	Belongs to the glycosyl hydrolase 3 family
B6V88_RS00110	COG2818	Glycosylase
B6V88_RS00125	COG0531	amino acid
B6V88_RS00135	COG0306	phosphate transporter
B6V88_RS00140	COG1253	flavin adenine dinucleotide binding
B6V88_RS00200	COG0436	Aminotransferase
B6V88_RS00220	COG3079	Belongs to the UPF0149 family
B6V88_RS00230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6V88_RS00235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6V88_RS00260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6V88_RS00270	COG0577	efflux transmembrane transporter activity
B6V88_RS00270	COG1136	(ABC) transporter
B6V88_RS00275	COG0656	L-ascorbic acid biosynthetic process
B6V88_RS00295	COG2824	Alkylphosphonate utilization operon protein PhnA
B6V88_RS00320	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B6V88_RS00360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B6V88_RS00380	COG1294	oxidase, subunit
B6V88_RS00385	COG1271	oxidase subunit
B6V88_RS00390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6V88_RS00425	COG0583	DNA-binding transcription factor activity
B6V88_RS00435	COG0671	phosphoesterase, PA-phosphatase related
B6V88_RS00440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6V88_RS00460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B6V88_RS00485	COG1475	DNA binding
B6V88_RS00490	COG1192	Involved in chromosome partitioning
B6V88_RS00495	COG0357	Ribosomal RNA small subunit methyltransferase G
B6V88_RS00525	COG2878	Part of a membrane complex involved in electron transport
B6V88_RS00530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B6V88_RS00555	COG0598	Magnesium transport protein CorA
B6V88_RS00565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6V88_RS00575	COG0252	asparaginase activity
B6V88_RS00585	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
B6V88_RS00590	COG0730	response to heat
B6V88_RS00595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B6V88_RS00600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B6V88_RS00615	COG1051	belongs to the nudix hydrolase family
B6V88_RS00620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B6V88_RS00635	COG1515	deoxyribonuclease V activity
B6V88_RS00640	COG0163	prenyltransferase activity
B6V88_RS00645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6V88_RS00670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B6V88_RS00705	COG1028	Short-chain dehydrogenase reductase Sdr
B6V88_RS00715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B6V88_RS00725	COG0714	Associated with various cellular activities
B6V88_RS00740	COG2304	oxidoreductase activity
B6V88_RS00765	COG1278	Cold shock
B6V88_RS00780	COG1671	Belongs to the UPF0178 family
B6V88_RS00800	COG0516	GMP reductase activity
B6V88_RS00805	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B6V88_RS00810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B6V88_RS00825	COG2183	response to ionizing radiation
B6V88_RS00840	COG2918	glutathione biosynthetic process
B6V88_RS00840	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6V88_RS00875	COG0497	DNA recombination
B6V88_RS00895	COG1217	gtp-binding protein TYPA
B6V88_RS00905	COG1114	Component of the transport system for branched-chain amino acids
B6V88_RS00925	COG3135	benzoate transporter
B6V88_RS00955	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B6V88_RS00960	COG0210	DNA helicase
B6V88_RS00990	COG2719	SpoVR family
B6V88_RS01000	COG2766	serine protein kinase
B6V88_RS01005	COG0308	aminopeptidase N
B6V88_RS01030	COG3104	oligopeptide transport
B6V88_RS01040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B6V88_RS01070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B6V88_RS01105	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6V88_RS01115	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B6V88_RS01120	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B6V88_RS01125	COG1034	ATP synthesis coupled electron transport
B6V88_RS01175	COG2251	uridine kinase activity
B6V88_RS01175	COG0195	Participates in both transcription termination and antitermination
B6V88_RS01190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6V88_RS01210	COG0302	gtp cyclohydrolase
B6V88_RS01215	COG0537	adenosine 5'-monophosphoramidase activity
B6V88_RS01220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B6V88_RS01235	COG0531	amino acid
B6V88_RS01250	COG0439	Biotin carboxylase
B6V88_RS01270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B6V88_RS01300	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B6V88_RS01320	COG2009	succinate dehydrogenase
B6V88_RS01325	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B6V88_RS01330	COG1053	succinate dehydrogenase
B6V88_RS01335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B6V88_RS01360	COG0300	oxidoreductase activity
B6V88_RS01405	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B6V88_RS01410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6V88_RS01425	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B6V88_RS01460	COG1028	Short-chain dehydrogenase reductase Sdr
B6V88_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
B6V88_RS01470	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
B6V88_RS01485	COG3243	poly(R)-hydroxyalkanoic acid synthase
B6V88_RS01495	COG1196	nuclear chromosome segregation
B6V88_RS01500	COG3115	cell septum assembly
B6V88_RS01505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6V88_RS01520	COG0772	Belongs to the SEDS family
B6V88_RS01575	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B6V88_RS01585	COG0546	phosphoglycolate phosphatase activity
B6V88_RS01600	COG0758	DNA mediated transformation
B6V88_RS01610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6V88_RS01630	COG1475	DNA binding
B6V88_RS01635	COG2027	D-alanyl-D-alanine carboxypeptidase
B6V88_RS01660	COG1054	Belongs to the UPF0176 family
B6V88_RS01685	COG1960	acyl-CoA dehydrogenase activity
B6V88_RS01740	COG1064	alcohol dehydrogenase
B6V88_RS01760	COG2271	Major facilitator Superfamily
B6V88_RS01765	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B6V88_RS01770	COG0735	belongs to the Fur family
B6V88_RS01790	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6V88_RS01790	COG2918	glutathione biosynthetic process
B6V88_RS01810	COG0659	secondary active sulfate transmembrane transporter activity
B6V88_RS01830	COG0708	Exodeoxyribonuclease III
B6V88_RS01845	COG0281	malic enzyme
B6V88_RS01850	COG2223	nitrite transmembrane transporter activity
B6V88_RS01860	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B6V88_RS01870	COG0814	amino acid
B6V88_RS01875	COG0814	amino acid
B6V88_RS01900	COG0700	Nucleoside recognition
B6V88_RS01910	COG0739	heme binding
B6V88_RS01940	COG1162	GTPase activity
B6V88_RS01955	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B6V88_RS01975	COG1959	2 iron, 2 sulfur cluster binding
B6V88_RS02005	COG0181	hydroxymethylbilane synthase activity
B6V88_RS02025	COG0784	Response regulator, receiver
B6V88_RS02040	COG2070	2-Nitropropane dioxygenase
B6V88_RS02060	COG0343	queuine tRNA-ribosyltransferase activity
B6V88_RS02065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B6V88_RS02070	COG2860	membrane
B6V88_RS02095	COG0477	Major facilitator Superfamily
B6V88_RS02145	COG0776	regulation of translation
B6V88_RS02160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B6V88_RS02165	COG0723	plastoquinol--plastocyanin reductase activity
B6V88_RS02170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B6V88_RS02175	COG2857	Cytochrome c1
B6V88_RS02180	COG0625	glutathione transferase activity
B6V88_RS02185	COG2969	positive regulation of protein catabolic process
B6V88_RS02195	COG0802	atpase or kinase
B6V88_RS02200	COG0860	N-Acetylmuramoyl-L-alanine amidase
B6V88_RS02205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B6V88_RS02235	COG2771	luxR family
B6V88_RS02255	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6V88_RS02255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B6V88_RS02270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B6V88_RS02270	COG0473	3-isopropylmalate dehydrogenase activity
B6V88_RS02295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6V88_RS02295	COG2755	lipolytic protein G-D-S-L family
B6V88_RS02335	COG0386	Belongs to the glutathione peroxidase family
B6V88_RS02375	COG0612	Peptidase, M16
B6V88_RS02380	COG0612	Peptidase, M16
B6V88_RS02385	COG0552	protein localization to endoplasmic reticulum
B6V88_RS02390	COG2884	Cell division ATP-binding protein ftsE
B6V88_RS02395	COG2177	Part of the ABC transporter FtsEX involved in
B6V88_RS02420	COG5002	protein histidine kinase activity
B6V88_RS02425	COG0745	RESPONSE REGULATOR receiver
B6V88_RS02435	COG0306	phosphate transporter
B6V88_RS02440	COG1392	Phosphate transport regulator
B6V88_RS02450	COG3243	poly(R)-hydroxyalkanoic acid synthase
B6V88_RS02480	COG0602	queuosine metabolic process
B6V88_RS02485	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B6V88_RS02490	COG2885	chlorophyll binding
B6V88_RS02495	COG3218	ABC-type transport auxiliary lipoprotein component
B6V88_RS02510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B6V88_RS02590	COG1064	alcohol dehydrogenase
B6V88_RS02600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B6V88_RS02695	COG0546	phosphoglycolate phosphatase activity
B6V88_RS02765	COG0494	nUDIX hydrolase
B6V88_RS02790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B6V88_RS02800	COG0425	Belongs to the sulfur carrier protein TusA family
B6V88_RS02805	COG0482	sulfurtransferase activity
B6V88_RS02820	COG0628	permease
B6V88_RS02860	COG2217	Heavy metal translocating P-type atpase
B6V88_RS02865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B6V88_RS02880	COG0429	hydrolase of the alpha beta-hydrolase fold
B6V88_RS02890	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B6V88_RS02920	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B6V88_RS02930	COG2755	lipolytic protein G-D-S-L family
B6V88_RS02930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6V88_RS02935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6V88_RS02940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6V88_RS02955	COG0762	integral membrane protein
B6V88_RS02975	COG1561	YicC-like family, N-terminal region
B6V88_RS02990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6V88_RS03000	COG3577	Aspartyl protease
B6V88_RS03005	COG0488	(ABC) transporter
B6V88_RS03030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6V88_RS03075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B6V88_RS03095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B6V88_RS03115	COG0572	uridine kinase
B6V88_RS03125	COG2890	protein-(glutamine-N5) methyltransferase activity
B6V88_RS03135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B6V88_RS03165	COG1530	ribonuclease E activity
B6V88_RS03170	COG0564	pseudouridine synthase activity
B6V88_RS03175	COG0546	phosphoglycolate phosphatase activity
B6V88_RS03220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B6V88_RS03225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B6V88_RS03230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B6V88_RS03245	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
B6V88_RS03270	COG0189	ligase activity
B6V88_RS03310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B6V88_RS03315	COG2853	Lipoprotein
B6V88_RS03330	COG0583	DNA-binding transcription factor activity
B6V88_RS03335	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B6V88_RS03350	COG0069	glutamate synthase activity
B6V88_RS03360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B6V88_RS03410	COG0606	chelatase, subunit chli
B6V88_RS03415	COG2960	long-chain fatty acid transporting porin activity
B6V88_RS03430	COG0347	Belongs to the P(II) protein family
B6V88_RS03440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B6V88_RS03455	COG0398	Pfam SNARE associated Golgi protein
B6V88_RS03460	COG0318	PFAM AMP-dependent synthetase and ligase
B6V88_RS03460	COG0204	Acyl-transferase
B6V88_RS03570	COG0450	alkyl hydroperoxide reductase
B6V88_RS03595	COG1902	pentaerythritol trinitrate reductase activity
B6V88_RS03595	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6V88_RS03600	COG0513	Belongs to the DEAD box helicase family
B6V88_RS03625	COG3240	lipase activity
B6V88_RS03635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B6V88_RS03645	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B6V88_RS03650	COG2890	protein-(glutamine-N5) methyltransferase activity
B6V88_RS03670	COG0750	zinc metalloprotease
B6V88_RS03675	COG1040	competence protein
B6V88_RS03680	COG2226	methyltransferase
B6V88_RS03685	COG2027	D-alanyl-D-alanine carboxypeptidase
B6V88_RS03695	COG2197	response regulator
B6V88_RS03700	COG0322	excinuclease ABC activity
B6V88_RS03795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B6V88_RS03810	COG0659	secondary active sulfate transmembrane transporter activity
B6V88_RS03820	COG1538	Outer membrane efflux protein
B6V88_RS03825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6V88_RS03830	COG0156	8-amino-7-oxononanoate synthase activity
B6V88_RS03840	COG0488	(ABC) transporter
B6V88_RS03880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6V88_RS03890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6V88_RS03895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6V88_RS03920	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B6V88_RS03925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B6V88_RS03930	COG0628	permease
B6V88_RS03945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6V88_RS03955	COG2267	carboxylic ester hydrolase activity
B6V88_RS04015	COG0205	6-phosphofructokinase activity
B6V88_RS04030	COG0745	RESPONSE REGULATOR receiver
B6V88_RS04035	COG0784	Response regulator, receiver
B6V88_RS04035	COG2205	protein histidine kinase activity
B6V88_RS04055	COG3774	pathogenesis
B6V88_RS04075	COG0783	Belongs to the Dps family
B6V88_RS04130	COG0667	Aldo Keto reductase
B6V88_RS04135	COG0187	DNA topoisomerase II activity
B6V88_RS04140	COG0489	protein tyrosine kinase activity
B6V88_RS04145	COG1074	ATP-dependent DNA helicase activity
B6V88_RS04165	COG0113	porphobilinogen synthase activity
B6V88_RS04175	COG0729	surface antigen
B6V88_RS04185	COG1546	Belongs to the CinA family
B6V88_RS04225	COG1201	RNA secondary structure unwinding
B6V88_RS04240	COG0438	transferase activity, transferring glycosyl groups
B6V88_RS04290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B6V88_RS04315	COG2132	Multicopper oxidase
B6V88_RS04340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6V88_RS04370	COG0277	FAD linked oxidase domain protein
B6V88_RS04385	COG3190	flagellar
B6V88_RS04395	COG1987	bacterial-type flagellum assembly
B6V88_RS04400	COG1684	flagellar biosynthetic protein fliR
B6V88_RS04430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B6V88_RS04435	COG1360	Flagellar Motor Protein
B6V88_RS04480	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B6V88_RS04480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6V88_RS04490	COG0312	modulator of DNA gyrase
B6V88_RS04505	COG0492	ferredoxin-NADP+ reductase activity
B6V88_RS04530	COG0586	Pfam SNARE associated Golgi protein
B6V88_RS04565	COG1677	Flagellar hook-basal body complex protein FliE
B6V88_RS04605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B6V88_RS04625	COG0542	response to heat
B6V88_RS04640	COG0697	spore germination
B6V88_RS04650	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B6V88_RS04665	COG0316	Belongs to the HesB IscA family
B6V88_RS04705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B6V88_RS04715	COG1994	Peptidase M50
B6V88_RS04720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B6V88_RS04730	COG0463	Glycosyl transferase, family 2
B6V88_RS04745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B6V88_RS04755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6V88_RS04770	COG0686	Belongs to the AlaDH PNT family
B6V88_RS04825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B6V88_RS04840	COG0589	response to stress
B6V88_RS04845	COG0589	response to stress
B6V88_RS04870	COG2340	Cysteine-rich secretory protein family
B6V88_RS04885	COG2814	Major facilitator Superfamily
B6V88_RS04895	COG0025	NhaP-type Na H and K H
B6V88_RS04900	COG1872	DUF167
B6V88_RS04905	COG0196	riboflavin kinase activity
B6V88_RS04915	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B6V88_RS04920	COG0800	Aldolase
B6V88_RS04955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B6V88_RS04955	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6V88_RS04960	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6V88_RS04985	COG0670	Belongs to the BI1 family
B6V88_RS04990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6V88_RS04995	COG0312	modulator of DNA gyrase
B6V88_RS05000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B6V88_RS05025	COG2066	Belongs to the glutaminase family
B6V88_RS05045	COG1137	ATPase activity
B6V88_RS05060	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B6V88_RS05075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B6V88_RS05080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B6V88_RS05105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B6V88_RS05130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6V88_RS05150	COG0833	amino acid
B6V88_RS05170	COG0756	dUTP diphosphatase activity
B6V88_RS05185	COG0667	Aldo Keto reductase
B6V88_RS05190	COG0300	oxidoreductase activity
B6V88_RS05205	COG1472	Belongs to the glycosyl hydrolase 3 family
B6V88_RS05250	COG0204	Acyl-transferase
B6V88_RS05255	COG0626	cystathionine gamma-synthase activity
B6V88_RS05260	COG5001	Diguanylate cyclase
B6V88_RS05260	COG3300	MHYT domain
B6V88_RS05285	COG2226	methyltransferase
B6V88_RS05285	COG2867	negative regulation of translational initiation
B6V88_RS05335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6V88_RS05360	COG0477	Major facilitator Superfamily
B6V88_RS05370	COG1815	bacterial-type flagellum-dependent cell motility
B6V88_RS05375	COG1558	bacterial-type flagellum-dependent cell motility
B6V88_RS05380	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B6V88_RS05385	COG1749	Flagellar hook protein flgE
B6V88_RS05410	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6V88_RS05410	COG3951	Flagellar rod assembly protein muramidase FlgJ
B6V88_RS05415	COG4786	Flagellar basal body rod
B6V88_RS05415	COG1256	bacterial-type flagellum assembly
B6V88_RS05425	COG1846	Transcriptional regulator
B6V88_RS05430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B6V88_RS05440	COG0288	reversible hydration of carbon dioxide
B6V88_RS05480	COG3321	synthase
B6V88_RS05480	COG1028	Short-chain dehydrogenase reductase Sdr
B6V88_RS05480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6V88_RS05480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6V88_RS05480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6V88_RS05550	COG1028	Short-chain dehydrogenase reductase Sdr
B6V88_RS05585	COG0604	alcohol dehydrogenase
B6V88_RS05615	COG1376	ErfK ybiS ycfS ynhG family protein
B6V88_RS05630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6V88_RS05645	COG2378	regulation of single-species biofilm formation
B6V88_RS05655	COG0281	malic enzyme
B6V88_RS05680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6V88_RS05685	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B6V88_RS05690	COG0217	transcriptional regulatory protein
B6V88_RS05695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B6V88_RS05720	COG2917	probably involved in intracellular septation
B6V88_RS05730	COG0784	Response regulator, receiver
B6V88_RS05730	COG2198	Histidine kinase
B6V88_RS05730	COG5002	protein histidine kinase activity
B6V88_RS05735	COG0741	lytic transglycosylase activity
B6V88_RS05735	COG1388	LysM domain
B6V88_RS05745	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B6V88_RS05770	COG2271	Major facilitator Superfamily
B6V88_RS05790	COG2409	Drug exporters of the RND superfamily
B6V88_RS05805	COG2270	Major facilitator Superfamily
B6V88_RS05810	COG5310	Homospermidine synthase
B6V88_RS05870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6V88_RS05890	COG1280	lysine exporter protein (LysE YggA)
B6V88_RS05900	COG3507	Belongs to the glycosyl hydrolase 43 family
B6V88_RS05900	COG3693	PFAM glycoside hydrolase, family 10
B6V88_RS05900	COG2382	esterase
B6V88_RS05905	COG0488	(ABC) transporter
B6V88_RS05910	COG1132	(ABC) transporter
B6V88_RS05930	COG0745	RESPONSE REGULATOR receiver
B6V88_RS05945	COG1042	CoA-binding domain protein
B6V88_RS05945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6V88_RS05945	COG0045	succinate-CoA ligase (ADP-forming) activity
B6V88_RS05965	COG0589	response to stress
B6V88_RS05970	COG0589	response to stress
B6V88_RS05975	COG2217	Heavy metal translocating P-type atpase
B6V88_RS06000	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B6V88_RS06015	COG0309	Hydrogenase expression formation protein (HypE)
B6V88_RS06030	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
B6V88_RS06080	COG0288	reversible hydration of carbon dioxide
B6V88_RS06085	COG0183	Belongs to the thiolase family
B6V88_RS06095	COG1376	ErfK ybiS ycfS ynhG family protein
B6V88_RS06145	COG1183	phosphatidylcholine synthase activity
B6V88_RS06150	COG1012	belongs to the aldehyde dehydrogenase family
B6V88_RS06165	COG3038	cytochrome b561
B6V88_RS06185	COG2255	four-way junction helicase activity
B6V88_RS06190	COG0824	Thioesterase
B6V88_RS06220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B6V88_RS06260	COG0318	PFAM AMP-dependent synthetase and ligase
B6V88_RS06265	COG0850	regulation of cytokinetic process
B6V88_RS06305	COG1426	Protein conserved in bacteria
B6V88_RS06315	COG2976	Protein conserved in bacteria
B6V88_RS06340	COG0617	tRNA 3'-terminal CCA addition
B6V88_RS06345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6V88_RS06360	COG1981	membrane
B6V88_RS06365	COG0861	Integral membrane protein TerC family
B6V88_RS06375	COG0857	belongs to the CobB CobQ family
B6V88_RS06375	COG0280	phosphate acetyltransferase
B6V88_RS06395	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B6V88_RS06400	COG0372	Belongs to the citrate synthase family
B6V88_RS06405	COG2079	MmgE PrpD family protein
B6V88_RS06410	COG1960	acyl-CoA dehydrogenase activity
B6V88_RS06435	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B6V88_RS06445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B6V88_RS06465	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B6V88_RS06475	COG3034	peptidoglycan biosynthetic process
B6V88_RS06485	COG0586	Pfam SNARE associated Golgi protein
B6V88_RS06495	COG2921	Belongs to the UPF0250 family
B6V88_RS06500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B6V88_RS06510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B6V88_RS06550	COG0285	dihydrofolate synthase activity
B6V88_RS06560	COG1286	toxin biosynthetic process
B6V88_RS06570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B6V88_RS06580	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
B6V88_RS06590	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B6V88_RS06600	COG1012	belongs to the aldehyde dehydrogenase family
B6V88_RS06610	COG0183	Belongs to the thiolase family
B6V88_RS06620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6V88_RS06625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6V88_RS06640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B6V88_RS06645	COG2843	Capsule synthesis protein
B6V88_RS06670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6V88_RS06680	COG1983	PspC domain protein
B6V88_RS06685	COG2373	Large extracellular alpha-helical protein
B6V88_RS06690	COG4953	penicillin-binding protein 1C
B6V88_RS06695	COG3791	Glutathione-dependent formaldehyde-activating
B6V88_RS06715	COG0436	Aminotransferase
B6V88_RS06725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B6V88_RS06730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B6V88_RS06760	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B6V88_RS06795	COG2200	EAL domain
B6V88_RS06810	COG0156	8-amino-7-oxononanoate synthase activity
B6V88_RS06840	COG3264	Mechanosensitive ion channel
B6V88_RS06840	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B6V88_RS06900	COG4221	oxidoreductase activity
B6V88_RS06905	COG0259	pyridoxamine-phosphate oxidase activity
B6V88_RS06910	COG3083	sulfuric ester hydrolase activity
B6V88_RS06925	COG0183	Belongs to the thiolase family
B6V88_RS06940	COG2755	lipolytic protein G-D-S-L family
B6V88_RS06940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6V88_RS06960	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B6V88_RS06975	COG2423	ornithine cyclodeaminase activity
B6V88_RS07035	COG2224	Isocitrate lyase
B6V88_RS07040	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B6V88_RS07090	COG0084	hydrolase, TatD family'
B6V88_RS07110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B6V88_RS07115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6V88_RS07130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B6V88_RS07135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6V88_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
B6V88_RS07190	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B6V88_RS07235	COG0772	Belongs to the SEDS family
B6V88_RS07250	COG0673	inositol 2-dehydrogenase activity
B6V88_RS07255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6V88_RS07260	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B6V88_RS07270	COG3781	membrane
B6V88_RS07285	COG0174	glutamine synthetase
B6V88_RS07300	COG2165	general secretion pathway protein
B6V88_RS07330	COG1028	Short-chain dehydrogenase reductase Sdr
B6V88_RS07340	COG1187	pseudouridine synthase activity
B6V88_RS07345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B6V88_RS07350	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B6V88_RS07355	COG0180	Tryptophanyl-tRNA synthetase
B6V88_RS07360	COG0009	L-threonylcarbamoyladenylate synthase
B6V88_RS07365	COG0613	PHP domain protein
B6V88_RS07370	COG2986	histidine ammonia-lyase
B6V88_RS07380	COG1702	phosphate starvation-inducible protein PhoH
B6V88_RS07395	COG0745	RESPONSE REGULATOR receiver
B6V88_RS07400	COG2205	protein histidine kinase activity
B6V88_RS07415	COG0295	cytidine deaminase activity
B6V88_RS07420	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B6V88_RS07440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6V88_RS07460	COG1573	uracil-dna glycosylase
B6V88_RS07475	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B6V88_RS07485	COG0539	negative regulation of cytoplasmic translation
B6V88_RS07490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B6V88_RS07495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6V88_RS07510	COG0372	Belongs to the citrate synthase family
B6V88_RS07520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6V88_RS07530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6V88_RS07560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6V88_RS07565	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6V88_RS07590	COG1294	oxidase, subunit
B6V88_RS07595	COG1271	oxidase subunit
B6V88_RS07600	COG2271	Major facilitator Superfamily
B6V88_RS07615	COG1496	oxidoreductase activity
B6V88_RS07680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6V88_RS07705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B6V88_RS07735	COG0814	amino acid
B6V88_RS07745	COG1234	tRNA 3'-trailer cleavage
B6V88_RS07765	COG2850	peptidyl-arginine hydroxylation
B6V88_RS07775	COG3144	bacterial-type flagellum assembly
B6V88_RS07785	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B6V88_RS07790	COG0531	amino acid
B6V88_RS07810	COG2353	YceI-like domain
B6V88_RS07845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B6V88_RS07860	COG3138	arginine N-succinyltransferase
B6V88_RS07900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B6V88_RS07900	COG4651	solute:proton antiporter activity
B6V88_RS07950	COG2894	cell division
B6V88_RS07960	COG1960	acyl-CoA dehydrogenase activity
B6V88_RS07975	COG3842	ATPase activity
B6V88_RS07980	COG0395	ABC-type sugar transport system, permease component
B6V88_RS07990	COG0604	alcohol dehydrogenase
B6V88_RS08005	COG0318	PFAM AMP-dependent synthetase and ligase
B6V88_RS08010	COG0038	chloride channel
B6V88_RS08015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6V88_RS08015	COG0512	Glutamine amidotransferase of anthranilate synthase
B6V88_RS08025	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6V88_RS08055	COG3245	cytochrome
B6V88_RS08065	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
B6V88_RS08085	COG1335	isochorismatase
B6V88_RS08095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B6V88_RS08100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B6V88_RS08115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B6V88_RS08130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B6V88_RS08130	COG0140	phosphoribosyl-ATP diphosphatase activity
B6V88_RS08145	COG2974	May be involved in recombination
B6V88_RS08175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6V88_RS08175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6V88_RS08180	COG0307	riboflavin synthase, alpha
B6V88_RS08195	COG4783	chaperone-mediated protein folding
B6V88_RS08200	COG5642	Protein of unknown function (DUF2384)
B6V88_RS08205	COG5654	RES domain protein
B6V88_RS08225	COG2271	Major facilitator Superfamily
B6V88_RS08275	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B6V88_RS08280	COG0693	protein deglycase activity
B6V88_RS08340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B6V88_RS08355	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B6V88_RS08360	COG0583	DNA-binding transcription factor activity
B6V88_RS08405	COG0582	viral genome integration into host DNA
B6V88_RS08435	COG0242	peptide deformylase activity
B6V88_RS08455	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
B6V88_RS08455	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
B6V88_RS08465	COG0542	response to heat
B6V88_RS08485	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B6V88_RS08585	COG1196	nuclear chromosome segregation
B6V88_RS08625	COG0629	single-stranded DNA binding
B6V88_RS08735	COG1024	Enoyl-CoA hydratase
B6V88_RS08740	COG1024	Enoyl-CoA hydratase
B6V88_RS08755	COG3360	Dodecin
B6V88_RS08780	COG1138	Cytochrome C-type biogenesis protein
B6V88_RS08795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B6V88_RS08820	COG1566	PFAM secretion protein HlyD family protein
B6V88_RS08825	COG2814	Major facilitator Superfamily
B6V88_RS08840	COG0616	signal peptide processing
B6V88_RS08865	COG2771	luxR family
B6V88_RS08880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6V88_RS08895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6V88_RS08920	COG3842	ATPase activity
B6V88_RS08925	COG1176	ABC-type spermidine putrescine transport system, permease component I
B6V88_RS08935	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B6V88_RS08965	COG0542	response to heat
B6V88_RS08980	COG1187	pseudouridine synthase activity
B6V88_RS08990	COG1792	Involved in formation and maintenance of cell shape
B6V88_RS08995	COG1077	Cell shape determining protein MreB Mrl
B6V88_RS09005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6V88_RS09020	COG0475	glutathione-regulated potassium exporter activity
B6V88_RS09025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6V88_RS09025	COG0574	Belongs to the PEP-utilizing enzyme family
B6V88_RS09030	COG0463	Glycosyl transferase, family 2
B6V88_RS09050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6V88_RS09055	COG1538	Outer membrane efflux protein
B6V88_RS09065	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B6V88_RS09070	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B6V88_RS09075	COG0531	amino acid
B6V88_RS09115	COG2223	nitrite transmembrane transporter activity
B6V88_RS09125	COG1760	l-serine dehydratase
B6V88_RS09135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6V88_RS09170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B6V88_RS09170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B6V88_RS09180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6V88_RS09225	COG2084	Dehydrogenase
B6V88_RS09245	COG0463	Glycosyl transferase, family 2
B6V88_RS09280	COG3104	oligopeptide transport
B6V88_RS09345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B6V88_RS09375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B6V88_RS09380	COG0741	lytic transglycosylase activity
B6V88_RS09400	COG0494	nUDIX hydrolase
B6V88_RS09410	COG1653	transport
B6V88_RS09415	COG0584	glycerophosphoryl diester phosphodiesterase
B6V88_RS09445	COG0625	glutathione transferase activity
B6V88_RS09465	COG1136	(ABC) transporter
B6V88_RS09470	COG4591	ABC-type transport system involved in lipoprotein release permease component
B6V88_RS09485	COG1522	sequence-specific DNA binding
B6V88_RS09490	COG2502	aspartate--ammonia ligase
B6V88_RS09520	COG2313	pseudouridylate synthase activity
B6V88_RS09585	COG0629	single-stranded DNA binding
B6V88_RS09620	COG2205	protein histidine kinase activity
B6V88_RS09685	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B6V88_RS09715	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B6V88_RS09725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6V88_RS09750	COG2409	Drug exporters of the RND superfamily
B6V88_RS09805	COG2274	protein secretion by the type I secretion system
B6V88_RS09810	COG2274	protein secretion by the type I secretion system
B6V88_RS09860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6V88_RS09880	COG3848	Pyruvate phosphate dikinase
B6V88_RS09880	COG0574	Belongs to the PEP-utilizing enzyme family
B6V88_RS09890	COG0069	glutamate synthase activity
B6V88_RS09895	COG0121	glutamine amidotransferase
B6V88_RS09900	COG0668	transmembrane transport
B6V88_RS09915	COG0531	amino acid
B6V88_RS09920	COG2814	Major facilitator Superfamily
B6V88_RS09925	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B6V88_RS09935	COG0415	Belongs to the DNA photolyase family
B6V88_RS09960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6V88_RS09965	COG0583	DNA-binding transcription factor activity
B6V88_RS09970	COG2274	protein secretion by the type I secretion system
B6V88_RS09995	COG1301	dicarboxylic acid transport
B6V88_RS10010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B6V88_RS10085	COG3655	Transcriptional regulator
B6V88_RS10165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6V88_RS10170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6V88_RS10175	COG1862	Preprotein translocase
B6V88_RS10180	COG0343	queuine tRNA-ribosyltransferase activity
B6V88_RS10185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B6V88_RS10200	COG0571	ribonuclease III activity
B6V88_RS10205	COG0681	Belongs to the peptidase S26 family
B6V88_RS10215	COG2951	lytic endotransglycosylase activity
B6V88_RS10290	COG3012	SEC-C Motif Domain Protein
B6V88_RS10305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B6V88_RS10310	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B6V88_RS10315	COG4786	Flagellar basal body rod
B6V88_RS10325	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B6V88_RS10330	COG1706	bacterial-type flagellum-dependent cell motility
B6V88_RS10345	COG1677	Flagellar hook-basal body complex protein FliE
B6V88_RS10350	COG1766	The M ring may be actively involved in energy transduction
B6V88_RS10365	COG1157	protein secretion by the type III secretion system
B6V88_RS10380	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B6V88_RS10395	COG1776	CheC inhibitor of MCP methylation
B6V88_RS10395	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B6V88_RS10460	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B6V88_RS10495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6V88_RS10560	COG4969	Belongs to the N-Me-Phe pilin family
B6V88_RS10570	COG0271	Belongs to the BolA IbaG family
B6V88_RS10580	COG0531	amino acid
B6V88_RS10600	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B6V88_RS10610	COG1214	PFAM Peptidase M22, glycoprotease
B6V88_RS10615	COG1199	ATP-dependent helicase activity
B6V88_RS10620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B6V88_RS10625	COG0435	Glutathione S-transferase
B6V88_RS10650	COG1028	Short-chain dehydrogenase reductase Sdr
B6V88_RS10655	COG4689	acetoacetate decarboxylase
B6V88_RS10700	COG1090	epimerase
B6V88_RS10725	COG2151	metal-sulfur cluster biosynthetic enzyme
B6V88_RS10745	COG0396	ATPase activity
B6V88_RS10755	COG1959	2 iron, 2 sulfur cluster binding
B6V88_RS10770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6V88_RS10780	COG0795	lipopolysaccharide-transporting ATPase activity
B6V88_RS10785	COG0795	lipopolysaccharide-transporting ATPase activity
B6V88_RS10795	COG2927	DNA polymerase III (CHI subunit)
B6V88_RS10850	COG1132	(ABC) transporter
B6V88_RS10875	COG1960	acyl-CoA dehydrogenase activity
B6V88_RS10880	COG0183	Belongs to the thiolase family
B6V88_RS10890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6V88_RS10915	COG1166	arginine decarboxylase activity
B6V88_RS10950	COG2011	ABC-type metal ion transport system permease component
B6V88_RS10955	COG1464	Belongs to the NlpA lipoprotein family
B6V88_RS10995	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B6V88_RS11000	COG0751	glycine-tRNA ligase activity
B6V88_RS11015	COG0210	DNA helicase
B6V88_RS11020	COG1278	Cold shock
B6V88_RS11025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B6V88_RS11095	COG1612	heme a metabolic process
B6V88_RS11115	COG0625	glutathione transferase activity
B6V88_RS11135	COG3220	belongs to the UPF0276 family
B6V88_RS11145	COG3038	cytochrome b561
B6V88_RS11155	COG0427	acetyl-CoA hydrolase
B6V88_RS11160	COG2301	Belongs to the HpcH HpaI aldolase family
B6V88_RS11165	COG2030	dehydratase
B6V88_RS11190	COG0789	Transcriptional regulator
B6V88_RS11200	COG2852	Protein conserved in bacteria
B6V88_RS11215	COG3706	GGDEF domain
B6V88_RS11235	COG0784	Response regulator, receiver
B6V88_RS11235	COG5002	protein histidine kinase activity
B6V88_RS11235	COG2198	Histidine kinase
B6V88_RS11245	COG1881	PFAM PEBP family protein
B6V88_RS11270	COG1566	PFAM secretion protein HlyD family protein
B6V88_RS11275	COG0477	Major facilitator Superfamily
B6V88_RS11280	COG0038	chloride channel
B6V88_RS11285	COG1301	dicarboxylic acid transport
B6V88_RS11290	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B6V88_RS11295	COG0300	oxidoreductase activity
B6V88_RS11335	COG0142	geranyltranstransferase activity
B6V88_RS11340	COG0668	transmembrane transport
B6V88_RS11350	COG1058	Belongs to the CinA family
B6V88_RS11350	COG1546	Belongs to the CinA family
B6V88_RS11355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6V88_RS11380	COG0012	GTP binding
B6V88_RS11390	COG5001	Diguanylate cyclase
B6V88_RS11390	COG3300	MHYT domain
B6V88_RS11395	COG0142	geranyltranstransferase activity
B6V88_RS11440	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6V88_RS11445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6V88_RS11450	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6V88_RS11485	COG4942	peptidase
B6V88_RS11490	COG0793	Belongs to the peptidase S41A family
B6V88_RS11515	COG0330	HflC and HflK could
B6V88_RS11520	COG0330	HflC and HflK could
B6V88_RS11545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B6V88_RS11555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6V88_RS11560	COG0277	FAD linked oxidase domain protein
B6V88_RS11575	COG1183	phosphatidylcholine synthase activity
B6V88_RS11590	COG0543	2 iron, 2 sulfur cluster binding
B6V88_RS11590	COG0633	Ferredoxin
B6V88_RS11595	COG3588	fructose-bisphosphate aldolase
B6V88_RS11600	COG3568	Endonuclease Exonuclease Phosphatase
B6V88_RS11605	COG1404	Belongs to the peptidase S8 family
B6V88_RS11615	COG3227	Zinc metalloprotease (Elastase)
B6V88_RS11620	COG0009	L-threonylcarbamoyladenylate synthase
B6V88_RS11625	COG5016	pyruvate
B6V88_RS11625	COG0511	ligase activity, forming carbon-carbon bonds
B6V88_RS11635	COG0511	ligase activity, forming carbon-carbon bonds
B6V88_RS11640	COG0439	Biotin carboxylase
B6V88_RS11645	COG2264	protein methyltransferase activity
B6V88_RS11660	COG2217	Heavy metal translocating P-type atpase
B6V88_RS11695	COG0494	nUDIX hydrolase
B6V88_RS11700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B6V88_RS11725	COG0358	DNA primase activity
B6V88_RS11755	COG2963	transposase activity
B6V88_RS11790	COG2081	HI0933 family
B6V88_RS11865	COG0745	RESPONSE REGULATOR receiver
B6V88_RS11910	COG0513	Belongs to the DEAD box helicase family
B6V88_RS11945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6V88_RS11965	COG0531	amino acid
B6V88_RS11970	COG0590	tRNA wobble adenosine to inosine editing
B6V88_RS12000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6V88_RS12025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6V88_RS12040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6V88_RS12055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6V88_RS12065	COG4221	oxidoreductase activity
B6V88_RS12120	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B6V88_RS12125	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B6V88_RS12125	COG0456	acetyltransferase
B6V88_RS12135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6V88_RS12155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6V88_RS12160	COG0756	dUTP diphosphatase activity
B6V88_RS12205	COG1902	pentaerythritol trinitrate reductase activity
B6V88_RS12215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6V88_RS12220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6V88_RS12240	COG0151	Belongs to the GarS family
B6V88_RS12245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B6V88_RS12255	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B6V88_RS12280	COG3475	LICD family
B6V88_RS12285	COG1850	ribulose-bisphosphate carboxylase activity
B6V88_RS12300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B6V88_RS12320	COG0842	Transport permease protein
B6V88_RS12325	COG1131	(ABC) transporter
B6V88_RS12335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6V88_RS12340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B6V88_RS12390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B6V88_RS12395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B6V88_RS12440	COG0572	uridine kinase
B6V88_RS12445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6V88_RS12460	COG0336	Belongs to the RNA methyltransferase TrmD family
B6V88_RS12490	COG1131	(ABC) transporter
B6V88_RS12495	COG0842	Transport permease protein
B6V88_RS12525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6V88_RS12530	COG0765	amino acid transport
B6V88_RS12535	COG1126	abc transporter atp-binding protein
B6V88_RS12540	COG0137	argininosuccinate synthase activity
B6V88_RS12545	COG0165	Argininosuccinate lyase
B6V88_RS12550	COG0505	Belongs to the CarA family
B6V88_RS12560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6V88_RS12605	COG1704	LemA family
B6V88_RS12615	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B6V88_RS12620	COG0352	thiamine-phosphate diphosphorylase activity
B6V88_RS12625	COG0745	RESPONSE REGULATOR receiver
B6V88_RS12680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B6V88_RS12700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6V88_RS12735	COG0494	nUDIX hydrolase
B6V88_RS12750	COG1380	Effector of murein hydrolase LrgA
B6V88_RS12755	COG0583	DNA-binding transcription factor activity
B6V88_RS12775	COG2205	protein histidine kinase activity
B6V88_RS12775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6V88_RS12785	COG2205	protein histidine kinase activity
B6V88_RS12785	COG0784	Response regulator, receiver
B6V88_RS12825	COG0433	COG0433 Predicted ATPase
B6V88_RS12830	COG0735	belongs to the Fur family
B6V88_RS12835	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6V88_RS12840	COG1335	isochorismatase
B6V88_RS12845	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B6V88_RS12855	COG2867	negative regulation of translational initiation
B6V88_RS12860	COG0400	carboxylic ester hydrolase activity
B6V88_RS12880	COG0569	domain protein
B6V88_RS12900	COG4232	protein-disulfide reductase activity
B6V88_RS12905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6V88_RS12920	COG1560	Kdo2-lipid A biosynthetic process
B6V88_RS12925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6V88_RS12930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6V88_RS12935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6V88_RS12945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6V88_RS12975	COG1028	Short-chain dehydrogenase reductase Sdr
B6V88_RS12980	COG2814	Major facilitator Superfamily
B6V88_RS12985	COG0629	single-stranded DNA binding
B6V88_RS13020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B6V88_RS13165	COG0222	ribosome binding
B6V88_RS13260	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B6V88_RS13270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6V88_RS13300	COG1509	lysine 2,3-aminomutase activity
B6V88_RS13305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6V88_RS13340	COG3101	peptidyl-lysine hydroxylation
B6V88_RS13350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B6V88_RS13400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6V88_RS13420	COG2226	methyltransferase
B6V88_RS13430	COG3527	Alpha-acetolactate decarboxylase
B6V88_RS13435	COG0028	Belongs to the TPP enzyme family
B6V88_RS13440	COG1028	Short-chain dehydrogenase reductase Sdr
B6V88_RS13445	COG3046	protein related to deoxyribodipyrimidine photolyase
B6V88_RS13465	COG1289	transmembrane transporter activity
B6V88_RS13480	COG2205	protein histidine kinase activity
B6V88_RS13480	COG0784	Response regulator, receiver
B6V88_RS13480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6V88_RS13480	COG2198	Histidine kinase
B6V88_RS13530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B6V88_RS13570	COG0582	viral genome integration into host DNA
B6V88_RS13580	COG0339	signal peptide processing
B6V88_RS13590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B6V88_RS13595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B6V88_RS13605	COG0469	pyruvate kinase activity
B6V88_RS13615	COG1116	anion transmembrane transporter activity
B6V88_RS13645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6V88_RS13655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6V88_RS13670	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B6V88_RS13685	COG2252	PERMEase
B6V88_RS13700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6V88_RS13715	COG3590	peptidase
B6V88_RS13745	COG0114	fumarate hydratase activity
B6V88_RS13755	COG1304	FMN binding
B6V88_RS13775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B6V88_RS13795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B6V88_RS13810	COG1125	glycine betaine transport
B6V88_RS13810	COG0517	IMP dehydrogenase activity
B6V88_RS13815	COG1174	glycine betaine transport
B6V88_RS13820	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6V88_RS13870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6V88_RS13875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6V88_RS13905	COG0776	regulation of translation
B6V88_RS13915	COG0330	HflC and HflK could
B6V88_RS13940	COG2885	chlorophyll binding
B6V88_RS13945	COG0418	dihydroorotase activity
B6V88_RS13950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6V88_RS13955	COG0450	alkyl hydroperoxide reductase
B6V88_RS13960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B6V88_RS13965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B6V88_RS13970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6V88_RS13975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6V88_RS13980	COG0557	exoribonuclease II activity
B6V88_RS14025	COG4067	protein conserved in archaea
B6V88_RS14025	COG0189	ligase activity
B6V88_RS14070	COG2226	methyltransferase
B6V88_RS14105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B6V88_RS14125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6V88_RS14130	COG2205	protein histidine kinase activity
B6V88_RS14130	COG0784	Response regulator, receiver
B6V88_RS14130	COG5002	protein histidine kinase activity
B6V88_RS14135	COG0805	protein transport
B6V88_RS14150	COG4106	trans-aconitate 2-methyltransferase activity
B6V88_RS14155	COG1215	transferase activity, transferring glycosyl groups
B6V88_RS14170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6V88_RS14180	COG0463	Glycosyl transferase, family 2
B6V88_RS14195	COG0028	Belongs to the TPP enzyme family
B6V88_RS14210	COG0463	Glycosyl transferase, family 2
B6V88_RS14220	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
B6V88_RS14255	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B6V88_RS14260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6V88_RS14285	COG0543	2 iron, 2 sulfur cluster binding
B6V88_RS14285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B6V88_RS14305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B6V88_RS14345	COG0477	Major facilitator Superfamily
B6V88_RS14420	COG2823	Periplasmic or secreted lipoprotein
B6V88_RS14425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B6V88_RS14430	COG0792	nuclease activity
B6V88_RS14435	COG3107	peptidoglycan biosynthetic process
B6V88_RS14440	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA