locus-tag	class	description
A7K99_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7K99_RS00010	COG0592	DNA-directed DNA polymerase activity
A7K99_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A7K99_RS00020	COG0187	DNA topoisomerase II activity
A7K99_RS00025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_RS00025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_RS00035	COG0561	phosphatase activity
A7K99_RS00055	COG0823	Involved in the tonB-independent uptake of proteins
A7K99_RS00060	COG5645	(Lipo)protein
A7K99_RS00065	COG0071	Belongs to the small heat shock protein (HSP20) family
A7K99_RS00075	COG3977	Valine--pyruvate aminotransferase
A7K99_RS00085	COG1609	Transcriptional regulator
A7K99_RS00090	COG2818	Glycosylase
A7K99_RS00100	COG1484	DNA-dependent DNA replication
A7K99_RS00105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_RS00110	COG1942	4-Oxalocrotonate Tautomerase
A7K99_RS00115	COG0431	NADPH-dependent FMN reductase
A7K99_RS00120	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A7K99_RS00125	COG0113	porphobilinogen synthase activity
A7K99_RS00140	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A7K99_RS00145	COG0425	Belongs to the sulfur carrier protein TusA family
A7K99_RS00150	COG3714	YhhN family
A7K99_RS00160	COG3776	membrane
A7K99_RS00165	COG0742	ribosomal rna small subunit methyltransferase
A7K99_RS00170	COG0552	protein localization to endoplasmic reticulum
A7K99_RS00175	COG2884	Cell division ATP-binding protein ftsE
A7K99_RS00180	COG2177	Part of the ABC transporter FtsEX involved in
A7K99_RS00190	COG0456	acetyltransferase
A7K99_RS00205	COG0395	ABC-type sugar transport system, permease component
A7K99_RS00215	COG0584	glycerophosphoryl diester phosphodiesterase
A7K99_RS00225	COG1741	Belongs to the pirin family
A7K99_RS00230	COG1609	Transcriptional regulator
A7K99_RS00235	COG3265	gluconokinase activity
A7K99_RS00240	COG2610	gluconate transmembrane transporter activity
A7K99_RS00245	COG2095	MarC family integral membrane protein
A7K99_RS00250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A7K99_RS00255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A7K99_RS00260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7K99_RS00270	COG1349	DNA-binding transcription factor activity
A7K99_RS00275	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A7K99_RS00275	COG0316	Belongs to the HesB IscA family
A7K99_RS00285	COG2267	carboxylic ester hydrolase activity
A7K99_RS00300	COG2183	response to ionizing radiation
A7K99_RS00305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7K99_RS00320	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A7K99_RS00325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A7K99_RS00330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A7K99_RS00340	COG0494	nUDIX hydrolase
A7K99_RS00345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A7K99_RS00370	COG4796	Type ii and iii secretion system protein
A7K99_RS00385	COG3266	domain, Protein
A7K99_RS00385	COG3266	domain, Protein
A7K99_RS00395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A7K99_RS00400	COG0546	phosphoglycolate phosphatase activity
A7K99_RS00410	COG0738	Major facilitator superfamily
A7K99_RS00430	COG1289	transmembrane transporter activity
A7K99_RS00440	COG1765	OsmC-like protein
A7K99_RS00445	COG3954	Phosphoribulokinase
A7K99_RS00455	COG0429	hydrolase of the alpha beta-hydrolase fold
A7K99_RS00465	COG0488	(ABC) transporter
A7K99_RS00470	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7K99_RS00475	COG0475	glutathione-regulated potassium exporter activity
A7K99_RS00475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7K99_RS00480	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A7K99_RS00485	COG1047	Peptidyl-prolyl cis-trans
A7K99_RS00490	COG2900	Belongs to the SlyX family
A7K99_RS00495	COG0545	Peptidyl-prolyl cis-trans isomerase
A7K99_RS00500	COG2964	Protein conserved in bacteria
A7K99_RS00510	COG2923	Belongs to the DsrF TusC family
A7K99_RS00520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A7K99_RS00540	COG2906	2 iron, 2 sulfur cluster binding
A7K99_RS00555	COG0051	transcription antitermination factor activity, RNA binding
A7K99_RS00560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7K99_RS00580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A7K99_RS00585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7K99_RS00595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7K99_RS00610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A7K99_RS00620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7K99_RS00630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7K99_RS00635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7K99_RS00640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7K99_RS00650	COG1841	ribosomal large subunit assembly
A7K99_RS00655	COG0200	Binds to the 23S rRNA
A7K99_RS00660	COG0201	protein transport
A7K99_RS00665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7K99_RS00675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A7K99_RS00690	COG0203	ribosomal protein L17
A7K99_RS00700	COG3036	rescue of stalled ribosome
A7K99_RS00705	COG1970	mechanosensitive ion channel activity
A7K99_RS00710	COG0569	domain protein
A7K99_RS00715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7K99_RS00715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7K99_RS00720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7K99_RS00730	COG0758	DNA mediated transformation
A7K99_RS00740	COG0551	DNA topoisomerase type I activity
A7K99_RS00750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7K99_RS00760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A7K99_RS00795	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A7K99_RS00800	COG1301	dicarboxylic acid transport
A7K99_RS00805	COG1802	Transcriptional regulator
A7K99_RS00815	COG1929	Belongs to the glycerate kinase type-1 family
A7K99_RS00820	COG2807	transmembrane transport
A7K99_RS00825	COG2207	Transcriptional regulator
A7K99_RS00865	COG2264	protein methyltransferase activity
A7K99_RS00870	COG4145	pantothenate transmembrane transporter activity
A7K99_RS00875	COG3924	membrane
A7K99_RS00880	COG0439	Biotin carboxylase
A7K99_RS00885	COG0511	ligase activity, forming carbon-carbon bonds
A7K99_RS00890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7K99_RS00895	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A7K99_RS00905	COG2200	EAL domain
A7K99_RS00905	COG2199	diguanylate cyclase activity
A7K99_RS00910	COG1077	Cell shape determining protein MreB Mrl
A7K99_RS00915	COG1792	Involved in formation and maintenance of cell shape
A7K99_RS00920	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A7K99_RS00930	COG1530	ribonuclease E activity
A7K99_RS00935	COG3164	Protein of unknown function
A7K99_RS00940	COG0312	modulator of DNA gyrase
A7K99_RS00945	COG0583	DNA-binding transcription factor activity
A7K99_RS00955	COG1566	PFAM secretion protein HlyD family protein
A7K99_RS00960	COG1289	transmembrane transporter activity
A7K99_RS00970	COG1438	arginine binding
A7K99_RS00975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7K99_RS00980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7K99_RS00985	COG3105	Protein conserved in bacteria
A7K99_RS00990	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A7K99_RS00995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7K99_RS01000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7K99_RS01005	COG0625	glutathione transferase activity
A7K99_RS01010	COG2969	positive regulation of protein catabolic process
A7K99_RS01015	COG0493	'glutamate synthase
A7K99_RS01020	COG0070	glutamate synthase
A7K99_RS01020	COG0069	glutamate synthase activity
A7K99_RS01020	COG0067	glutamate synthase
A7K99_RS01025	COG0784	Response regulator, receiver
A7K99_RS01025	COG2198	Histidine kinase
A7K99_RS01025	COG5002	protein histidine kinase activity
A7K99_RS01040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_RS01045	COG1660	Displays ATPase and GTPase activities
A7K99_RS01055	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A7K99_RS01060	COG1137	ATPase activity
A7K99_RS01065	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A7K99_RS01070	COG3117	lipopolysaccharide transmembrane transporter activity
A7K99_RS01075	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A7K99_RS01080	COG0517	IMP dehydrogenase activity
A7K99_RS01080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A7K99_RS01085	COG0530	calcium, potassium:sodium antiporter activity
A7K99_RS01090	COG1127	ABC transporter
A7K99_RS01095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7K99_RS01100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7K99_RS01105	COG2854	intermembrane phospholipid transfer
A7K99_RS01110	COG3113	response to antibiotic
A7K99_RS01115	COG5007	Belongs to the BolA IbaG family
A7K99_RS01125	COG3423	Transcriptional regulator
A7K99_RS01135	COG0142	geranyltranstransferase activity
A7K99_RS01140	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A7K99_RS01145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7K99_RS01150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A7K99_RS01155	COG2050	protein possibly involved in aromatic compounds catabolism
A7K99_RS01160	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS01165	COG3433	isochorismatase activity
A7K99_RS01165	COG1535	isochorismatase
A7K99_RS01170	COG1021	2,3-dihydroxybenzoate-AMP ligase
A7K99_RS01175	COG1169	isochorismate synthase
A7K99_RS01180	COG4592	Periplasmic binding protein
A7K99_RS01185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_RS01190	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_RS01195	COG1120	ATPase activity
A7K99_RS01200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7K99_RS01200	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A7K99_RS01210	COG2382	esterase
A7K99_RS01215	COG4771	TonB-dependent receptor
A7K99_RS01220	COG2027	D-alanyl-D-alanine carboxypeptidase
A7K99_RS01230	COG1534	Rna-binding protein
A7K99_RS01235	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A7K99_RS01245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A7K99_RS01250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7K99_RS01255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A7K99_RS01270	COG0779	Required for maturation of 30S ribosomal subunits
A7K99_RS01290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A7K99_RS01295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7K99_RS01300	COG1185	polyribonucleotide nucleotidyltransferase activity
A7K99_RS01310	COG0513	Belongs to the DEAD box helicase family
A7K99_RS01315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS01320	COG0826	peptidase U32
A7K99_RS01325	COG0826	peptidase U32
A7K99_RS01330	COG3154	lipid carrier protein
A7K99_RS01335	COG3153	acetyltransferase
A7K99_RS01340	COG2827	Endonuclease containing a URI domain
A7K99_RS01345	COG3787	Belongs to the UPF0306 family
A7K99_RS01355	COG0602	queuosine metabolic process
A7K99_RS01380	COG1438	arginine binding
A7K99_RS01385	COG1288	antiporter activity
A7K99_RS01395	COG0549	Belongs to the carbamate kinase family
A7K99_RS01410	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A7K99_RS01435	COG1126	abc transporter atp-binding protein
A7K99_RS01440	COG0765	amino acid transport
A7K99_RS01445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS01455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A7K99_RS01465	COG0154	amidase activity
A7K99_RS01480	COG0765	amino acid transport
A7K99_RS01485	COG0765	amino acid transport
A7K99_RS01490	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A7K99_RS01500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A7K99_RS01510	COG2927	DNA polymerase III (CHI subunit)
A7K99_RS01515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A7K99_RS01520	COG0795	lipopolysaccharide-transporting ATPase activity
A7K99_RS01525	COG0795	lipopolysaccharide-transporting ATPase activity
A7K99_RS01530	COG3210	domain, Protein
A7K99_RS01530	COG3468	outer membrane autotransporter barrel domain protein
A7K99_RS01535	COG2733	membrane
A7K99_RS01540	COG0583	DNA-binding transcription factor activity
A7K99_RS01550	COG0477	Major facilitator Superfamily
A7K99_RS01555	COG0433	COG0433 Predicted ATPase
A7K99_RS01595	COG0582	viral genome integration into host DNA
A7K99_RS01615	COG2963	transposase activity
A7K99_RS01700	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A7K99_RS01700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7K99_RS01705	COG3835	regulator
A7K99_RS01710	COG3875	lactate racemase activity
A7K99_RS01720	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A7K99_RS01730	COG1691	(AIR) carboxylase
A7K99_RS01745	COG3708	Transcriptional regulator
A7K99_RS01745	COG2207	Transcriptional regulator
A7K99_RS01770	COG2814	Major facilitator Superfamily
A7K99_RS01825	COG0477	Major facilitator Superfamily
A7K99_RS01840	COG1741	Belongs to the pirin family
A7K99_RS01885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS01910	COG2011	ABC-type metal ion transport system permease component
A7K99_RS01920	COG0477	Major facilitator Superfamily
A7K99_RS01950	COG2223	nitrite transmembrane transporter activity
A7K99_RS01960	COG1609	Transcriptional regulator
A7K99_RS01975	COG1846	Transcriptional regulator
A7K99_RS01980	COG5642	Protein of unknown function (DUF2384)
A7K99_RS01985	COG5654	RES domain protein
A7K99_RS01990	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS02000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS02005	COG0765	amino acid transport
A7K99_RS02015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_RS02020	COG4948	Mandelate Racemase Muconate Lactonizing
A7K99_RS02025	COG0006	proline dipeptidase activity
A7K99_RS02030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7K99_RS02035	COG0504	CTP synthase activity
A7K99_RS02045	COG0384	phenazine biosynthesis protein PhzF
A7K99_RS02055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7K99_RS02060	COG3275	phosphorelay sensor kinase activity
A7K99_RS02070	COG0523	cobalamin synthesis protein
A7K99_RS02075	COG2879	small protein
A7K99_RS02080	COG1966	Carbon starvation protein
A7K99_RS02085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_RS02085	COG2213	PTS system mannitol-specific
A7K99_RS02090	COG0246	Mannitol dehydrogenase
A7K99_RS02095	COG3722	fumarate hydratase activity
A7K99_RS02105	COG3210	domain, Protein
A7K99_RS02165	COG1129	ABC transporter
A7K99_RS02190	COG2271	Major facilitator Superfamily
A7K99_RS02195	COG0371	Dehydrogenase
A7K99_RS02200	COG1064	alcohol dehydrogenase
A7K99_RS02205	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A7K99_RS02205	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A7K99_RS02225	COG4608	Belongs to the ABC transporter superfamily
A7K99_RS02230	COG0444	Belongs to the ABC transporter superfamily
A7K99_RS02235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7K99_RS02240	COG0601	transmembrane transport
A7K99_RS02245	COG0747	negative chemotaxis
A7K99_RS02250	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A7K99_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS02265	COG1408	metallophosphoesterase
A7K99_RS02285	COG0456	acetyltransferase
A7K99_RS02290	COG0038	chloride channel
A7K99_RS02295	COG1560	Kdo2-lipid A biosynthetic process
A7K99_RS02315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_RS02320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7K99_RS02325	COG2731	YhcH YjgK YiaL family protein
A7K99_RS02330	COG2271	Major facilitator Superfamily
A7K99_RS02340	COG0738	Major facilitator superfamily
A7K99_RS02345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_RS02355	COG1609	Transcriptional regulator
A7K99_RS02360	COG2186	Transcriptional regulator
A7K99_RS02365	COG3734	2-keto-3-deoxy-galactonokinase
A7K99_RS02370	COG0800	Aldolase
A7K99_RS02385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7K99_RS02390	COG3385	transposase activity
A7K99_RS02395	COG1621	beta-fructofuranosidase activity
A7K99_RS02405	COG1621	beta-fructofuranosidase activity
A7K99_RS02420	COG3720	iron ion transport
A7K99_RS02425	COG4558	Periplasmic binding protein
A7K99_RS02430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_RS02435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A7K99_RS02445	COG0306	phosphate transporter
A7K99_RS02450	COG3550	peptidyl-serine autophosphorylation
A7K99_RS02455	COG3550	peptidyl-serine autophosphorylation
A7K99_RS02470	COG0673	inositol 2-dehydrogenase activity
A7K99_RS02480	COG0747	negative chemotaxis
A7K99_RS02485	COG0601	transmembrane transport
A7K99_RS02490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7K99_RS02500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS02540	COG4172	Belongs to the ABC transporter superfamily
A7K99_RS02545	COG1446	asparaginase
A7K99_RS02555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7K99_RS02560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_RS02565	COG1349	DNA-binding transcription factor activity
A7K99_RS02590	COG2963	transposase activity
A7K99_RS02595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7K99_RS02600	COG0235	Class ii aldolase
A7K99_RS02605	COG3623	hexulose-6-phosphate isomerase
A7K99_RS02610	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A7K99_RS02615	COG1070	Carbohydrate kinase
A7K99_RS02625	COG2731	YhcH YjgK YiaL family protein
A7K99_RS02635	COG1414	Transcriptional regulator
A7K99_RS02645	COG2211	Major facilitator Superfamily
A7K99_RS02660	COG0583	DNA-binding transcription factor activity
A7K99_RS02670	COG0431	NADPH-dependent FMN reductase
A7K99_RS02680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS02690	COG0765	amino acid transport
A7K99_RS02715	COG1802	Transcriptional regulator
A7K99_RS02720	COG1126	abc transporter atp-binding protein
A7K99_RS02725	COG0765	amino acid transport
A7K99_RS02730	COG0765	amino acid transport
A7K99_RS02735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS02740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_RS02760	COG0586	Pfam SNARE associated Golgi protein
A7K99_RS02800	COG0791	NLP P60 protein
A7K99_RS02805	COG0402	S-adenosylhomocysteine deaminase activity
A7K99_RS02810	COG2188	Transcriptional regulator
A7K99_RS02820	COG2986	histidine ammonia-lyase
A7K99_RS02845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A7K99_RS02850	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7K99_RS02865	COG1063	alcohol dehydrogenase
A7K99_RS02870	COG2610	gluconate transmembrane transporter activity
A7K99_RS02875	COG2706	6-phosphogluconolactonase activity
A7K99_RS02930	COG3842	ATPase activity
A7K99_RS02935	COG0583	DNA-binding transcription factor activity
A7K99_RS02940	COG0129	dihydroxy-acid dehydratase activity
A7K99_RS02950	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_RS02965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_RS02975	COG0531	amino acid
A7K99_RS02980	COG0697	spore germination
A7K99_RS02995	COG1984	allophanate hydrolase subunit 2
A7K99_RS03000	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A7K99_RS03025	COG4221	oxidoreductase activity
A7K99_RS03035	COG0765	amino acid transport
A7K99_RS03045	COG3012	SEC-C Motif Domain Protein
A7K99_RS03045	COG3318	Belongs to the UPF0149 family
A7K99_RS03055	COG4580	involved in the transport of maltose and maltodextrins
A7K99_RS03070	COG2182	Extracellular solute-binding protein
A7K99_RS03075	COG1175	transmembrane transport
A7K99_RS03080	COG3833	ABC-type maltose transport systems, permease component
A7K99_RS03100	COG1640	4-alpha-glucanotransferase
A7K99_RS03105	COG0058	SHG alpha-glucan phosphorylase activity
A7K99_RS03110	COG2909	trisaccharide binding
A7K99_RS03140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_RS03145	COG0697	spore germination
A7K99_RS03150	COG2072	flavoprotein involved in K transport
A7K99_RS03165	COG1126	abc transporter atp-binding protein
A7K99_RS03180	COG3395	kinase activity
A7K99_RS03200	COG0235	Class ii aldolase
A7K99_RS03205	COG1349	DNA-binding transcription factor activity
A7K99_RS03215	COG0358	DNA primase activity
A7K99_RS03220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A7K99_RS03240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A7K99_RS03250	COG0617	tRNA 3'-terminal CCA addition
A7K99_RS03255	COG4991	sh3 domain protein
A7K99_RS03260	COG3025	triphosphatase activity
A7K99_RS03285	COG3384	dioxygenase
A7K99_RS03290	COG0754	glutathionylspermidine amidase activity
A7K99_RS03305	COG0494	nUDIX hydrolase
A7K99_RS03310	COG3151	Protein conserved in bacteria
A7K99_RS03315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7K99_RS03320	COG3150	esterase
A7K99_RS03335	COG4771	TonB-dependent receptor
A7K99_RS03340	COG2819	hydrolase of the alpha beta superfamily
A7K99_RS03345	COG1396	sequence-specific DNA binding
A7K99_RS03350	COG1247	-acetyltransferase
A7K99_RS03370	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7K99_RS03390	COG2132	Multicopper oxidase
A7K99_RS03400	COG0656	L-ascorbic acid biosynthetic process
A7K99_RS03405	COG2207	Transcriptional regulator
A7K99_RS03415	COG0626	cystathionine gamma-synthase activity
A7K99_RS03425	COG0848	biopolymer transport protein
A7K99_RS03440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_RS03455	COG2308	Evidence 4 Homologs of previously reported genes of
A7K99_RS03465	COG1305	Transglutaminase-like
A7K99_RS03480	COG1528	Iron-storage protein
A7K99_RS03485	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A7K99_RS03490	COG2271	Major facilitator Superfamily
A7K99_RS03500	COG2823	Periplasmic or secreted lipoprotein
A7K99_RS03510	COG0084	hydrolase, TatD family'
A7K99_RS03520	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A7K99_RS03525	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A7K99_RS03545	COG0582	viral genome integration into host DNA
A7K99_RS03595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS03600	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_RS03610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7K99_RS03615	COG3622	Belongs to the hyi family
A7K99_RS03625	COG2837	iron assimilation
A7K99_RS03630	COG2822	iron ion transport
A7K99_RS03655	COG4993	Dehydrogenase
A7K99_RS03680	COG0765	amino acid transport
A7K99_RS03685	COG0765	amino acid transport
A7K99_RS03705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7K99_RS03720	COG1741	Belongs to the pirin family
A7K99_RS03730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7K99_RS03750	COG0583	DNA-binding transcription factor activity
A7K99_RS03760	COG0604	alcohol dehydrogenase
A7K99_RS03765	COG1902	pentaerythritol trinitrate reductase activity
A7K99_RS03775	COG4106	trans-aconitate 2-methyltransferase activity
A7K99_RS03790	COG0738	Major facilitator superfamily
A7K99_RS03805	COG1609	Transcriptional regulator
A7K99_RS03815	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS03825	COG1609	Transcriptional regulator
A7K99_RS03830	COG2181	nitrate reductase activity
A7K99_RS03835	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A7K99_RS03840	COG1140	nitrate reductase beta subunit
A7K99_RS03845	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A7K99_RS03850	COG2223	nitrite transmembrane transporter activity
A7K99_RS03855	COG2146	nitrite reductase [NAD(P)H] activity
A7K99_RS03860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7K99_RS03875	COG0702	epimerase
A7K99_RS03880	COG1733	regulation of RNA biosynthetic process
A7K99_RS03885	COG2375	cellular response to nickel ion
A7K99_RS03890	COG1695	Transcriptional regulator
A7K99_RS03900	COG0604	alcohol dehydrogenase
A7K99_RS03905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_RS03915	COG1982	Orn Lys Arg decarboxylase major
A7K99_RS03920	COG0741	lytic transglycosylase activity
A7K99_RS03925	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A7K99_RS03930	COG1194	a g-specific adenine glycosylase
A7K99_RS03940	COG3171	Protein conserved in bacteria
A7K99_RS03950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7K99_RS03955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A7K99_RS03960	COG0762	integral membrane protein
A7K99_RS03965	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A7K99_RS03970	COG2805	Type II/IV secretion system protein
A7K99_RS03985	COG1678	Uncharacterized ACR, COG1678
A7K99_RS03995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A7K99_RS04005	COG2814	Major facilitator Superfamily
A7K99_RS04010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7K99_RS04020	COG1166	arginine decarboxylase activity
A7K99_RS04025	COG0010	Belongs to the arginase family
A7K99_RS04030	COG3753	Protein conserved in bacteria
A7K99_RS04050	COG1024	Enoyl-CoA hydratase
A7K99_RS04065	COG1473	amidohydrolase
A7K99_RS04075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7K99_RS04085	COG0126	phosphoglycerate kinase activity
A7K99_RS04100	COG2084	Dehydrogenase
A7K99_RS04105	COG0668	transmembrane transport
A7K99_RS04125	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A7K99_RS04130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7K99_RS04135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7K99_RS04150	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A7K99_RS04160	COG0006	proline dipeptidase activity
A7K99_RS04165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7K99_RS04170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7K99_RS04175	COG1335	isochorismatase
A7K99_RS04185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_RS04205	COG0509	glycine decarboxylation via glycine cleavage system
A7K99_RS04220	COG1272	protein, Hemolysin III
A7K99_RS04225	COG0354	folic acid binding
A7K99_RS04230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A7K99_RS04240	COG0716	FMN binding
A7K99_RS04245	COG4974	Belongs to the 'phage' integrase family
A7K99_RS04250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7K99_RS04265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A7K99_RS04295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7K99_RS04305	COG1088	dTDP-glucose 4,6-dehydratase activity
A7K99_RS04375	COG1482	cell wall glycoprotein biosynthetic process
A7K99_RS04380	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_RS04380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7K99_RS04385	COG3715	PTS system
A7K99_RS04390	COG3716	PTS system mannose fructose sorbose family IID component
A7K99_RS04405	COG1486	melibiose metabolic process
A7K99_RS04410	COG1447	Phosphotransferase system cellobiose-specific component IIA
A7K99_RS04415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7K99_RS04420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7K99_RS04425	COG2814	Major facilitator Superfamily
A7K99_RS04430	COG0583	DNA-binding transcription factor activity
A7K99_RS04440	COG0346	lactoylglutathione lyase activity
A7K99_RS04455	COG0768	penicillin binding
A7K99_RS04465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_RS04470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7K99_RS04485	COG0318	PFAM AMP-dependent synthetase and ligase
A7K99_RS04485	COG0204	Acyl-transferase
A7K99_RS04490	COG0477	Major facilitator Superfamily
A7K99_RS04495	COG0667	Aldo Keto reductase
A7K99_RS04505	COG0861	Integral membrane protein TerC family
A7K99_RS04515	COG1051	belongs to the nudix hydrolase family
A7K99_RS04520	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
A7K99_RS04525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A7K99_RS04555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A7K99_RS04560	COG1074	ATP-dependent DNA helicase activity
A7K99_RS04565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7K99_RS04570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7K99_RS04570	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A7K99_RS04580	COG0531	amino acid
A7K99_RS04585	COG1982	Orn Lys Arg decarboxylase major
A7K99_RS04590	COG1438	arginine binding
A7K99_RS04620	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A7K99_RS04625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A7K99_RS04630	COG2166	iron-sulfur cluster assembly
A7K99_RS04635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7K99_RS04645	COG0583	DNA-binding transcription factor activity
A7K99_RS04650	COG2363	Small membrane protein
A7K99_RS04655	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A7K99_RS04665	COG1611	Belongs to the LOG family
A7K99_RS04680	COG3098	single-species biofilm formation
A7K99_RS04685	COG0564	pseudouridine synthase activity
A7K99_RS04690	COG0716	FMN binding
A7K99_RS04695	COG4999	Histidine kinase
A7K99_RS04695	COG3850	Histidine kinase
A7K99_RS04695	COG3437	response regulator, receiver
A7K99_RS04695	COG2205	protein histidine kinase activity
A7K99_RS04700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7K99_RS04705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7K99_RS04710	COG3956	TIGRFAM MazG family protein
A7K99_RS04720	COG0504	CTP synthase activity
A7K99_RS04725	COG0148	phosphopyruvate hydratase activity
A7K99_RS04750	COG4964	Belongs to the GSP D family
A7K99_RS04805	COG0602	queuosine metabolic process
A7K99_RS04810	COG0720	synthase
A7K99_RS04815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A7K99_RS04820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7K99_RS04825	COG0175	sulfate reduction
A7K99_RS04830	COG2234	aminopeptidase activity
A7K99_RS04835	COG1648	precorrin-2 dehydrogenase activity
A7K99_RS04835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7K99_RS04840	COG0175	sulfate reduction
A7K99_RS04860	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A7K99_RS04875	COG0585	pseudouridine synthase activity
A7K99_RS04880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A7K99_RS04890	COG1388	LysM domain
A7K99_RS04890	COG4942	peptidase
A7K99_RS04895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7K99_RS04900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A7K99_RS04910	COG2951	lytic endotransglycosylase activity
A7K99_RS04915	COG2824	Alkylphosphonate utilization operon protein PhnA
A7K99_RS04920	COG1546	Belongs to the CinA family
A7K99_RS04940	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7K99_RS04980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7K99_RS04985	COG2918	glutathione biosynthetic process
A7K99_RS04990	COG1854	S-ribosylhomocysteine lyase activity
A7K99_RS04995	COG4536	flavin adenine dinucleotide binding
A7K99_RS05000	COG4137	Cytochrome C assembly protein
A7K99_RS05005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7K99_RS05010	COG0228	four-way junction DNA binding
A7K99_RS05025	COG0335	large ribosomal subunit rRNA binding
A7K99_RS05045	COG1064	alcohol dehydrogenase
A7K99_RS05050	COG2186	Transcriptional regulator
A7K99_RS05060	COG1764	response to oxidative stress
A7K99_RS05110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A7K99_RS05115	COG1671	Belongs to the UPF0178 family
A7K99_RS05120	COG3416	Protein conserved in bacteria
A7K99_RS05125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A7K99_RS05130	COG0765	amino acid transport
A7K99_RS05135	COG4597	amino acid ABC transporter
A7K99_RS05145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS05155	COG2974	May be involved in recombination
A7K99_RS05160	COG0531	amino acid
A7K99_RS05175	COG0419	ATPase involved in DNA repair
A7K99_RS05180	COG0420	3'-5' exonuclease activity
A7K99_RS05185	COG0745	RESPONSE REGULATOR receiver
A7K99_RS05190	COG5002	protein histidine kinase activity
A7K99_RS05195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7K99_RS05210	COG0668	transmembrane transport
A7K99_RS05220	COG0450	alkyl hydroperoxide reductase
A7K99_RS05225	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A7K99_RS05230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7K99_RS05240	COG1862	Preprotein translocase
A7K99_RS05250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7K99_RS05255	COG3385	transposase activity
A7K99_RS05265	COG1652	LysM domain
A7K99_RS05275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7K99_RS05275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7K99_RS05280	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7K99_RS05285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7K99_RS05290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A7K99_RS05295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A7K99_RS05300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A7K99_RS05305	COG0142	geranyltranstransferase activity
A7K99_RS05310	COG1722	exodeoxyribonuclease VII activity
A7K99_RS05315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7K99_RS05315	COG0301	tRNA thio-modification
A7K99_RS05320	COG0693	protein deglycase activity
A7K99_RS05325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A7K99_RS05330	COG1666	GTP binding
A7K99_RS05335	COG2814	Major facilitator Superfamily
A7K99_RS05340	COG0109	protoheme IX farnesyltransferase activity
A7K99_RS05345	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A7K99_RS05350	COG1845	cytochrome c oxidase, subunit III
A7K99_RS05355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A7K99_RS05360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A7K99_RS05365	COG2223	nitrite transmembrane transporter activity
A7K99_RS05370	COG3056	Lipoprotein
A7K99_RS05375	COG0271	Belongs to the BolA IbaG family
A7K99_RS05385	COG0740	serine-type endopeptidase activity
A7K99_RS05395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7K99_RS05400	COG0776	regulation of translation
A7K99_RS05405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7K99_RS05410	COG1555	photosystem II stabilization
A7K99_RS05415	COG0824	Thioesterase
A7K99_RS05430	COG1522	sequence-specific DNA binding
A7K99_RS05435	COG1132	(ABC) transporter
A7K99_RS05440	COG1132	(ABC) transporter
A7K99_RS05445	COG0347	Belongs to the P(II) protein family
A7K99_RS05450	COG0004	ammonium transporteR
A7K99_RS05460	COG2814	Major facilitator Superfamily
A7K99_RS05470	COG1946	Acyl-CoA thioesterase
A7K99_RS05475	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A7K99_RS05480	COG3695	enzyme binding
A7K99_RS05500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7K99_RS05510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7K99_RS05515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_RS05520	COG1309	transcriptional regulator
A7K99_RS05535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7K99_RS05545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7K99_RS05550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7K99_RS05555	COG0326	Molecular chaperone. Has ATPase activity
A7K99_RS05560	COG0563	adenylate kinase activity
A7K99_RS05565	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A7K99_RS05570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_RS05575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7K99_RS05575	COG4651	solute:proton antiporter activity
A7K99_RS05590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A7K99_RS05595	COG3735	TraB family
A7K99_RS05600	COG2217	Heavy metal translocating P-type atpase
A7K99_RS05610	COG3118	belongs to the thioredoxin family
A7K99_RS05615	COG0300	oxidoreductase activity
A7K99_RS05620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A7K99_RS05625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A7K99_RS05635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7K99_RS05640	COG0215	cysteine-tRNA ligase activity
A7K99_RS05645	COG2501	S4 domain
A7K99_RS05695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A7K99_RS05750	COG0583	DNA-binding transcription factor activity
A7K99_RS05755	COG0596	Alpha beta hydrolase
A7K99_RS05760	COG0745	RESPONSE REGULATOR receiver
A7K99_RS05765	COG2205	protein histidine kinase activity
A7K99_RS05795	COG1082	Xylose isomerase domain protein TIM barrel
A7K99_RS05795	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A7K99_RS05805	COG2207	Transcriptional regulator
A7K99_RS05815	COG0432	Pfam Uncharacterised protein family UPF0047
A7K99_RS05820	COG2353	YceI-like domain
A7K99_RS05825	COG0110	maltose O-acetyltransferase activity
A7K99_RS05830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7K99_RS05860	COG1064	alcohol dehydrogenase
A7K99_RS05865	COG1733	regulation of RNA biosynthetic process
A7K99_RS05875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS05880	COG2272	Belongs to the type-B carboxylesterase lipase family
A7K99_RS05885	COG0667	Aldo Keto reductase
A7K99_RS05890	COG1742	UPF0060 membrane protein
A7K99_RS05895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7K99_RS05910	COG5285	phytanoyl-CoA dioxygenase
A7K99_RS05950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A7K99_RS05960	COG1278	Cold shock
A7K99_RS05965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7K99_RS05970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A7K99_RS05975	COG0321	lipoyl(octanoyl) transferase activity
A7K99_RS05985	COG1686	Belongs to the peptidase S11 family
A7K99_RS05990	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7K99_RS05995	COG0772	Belongs to the SEDS family
A7K99_RS06000	COG0768	penicillin binding
A7K99_RS06005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A7K99_RS06010	COG0799	negative regulation of ribosome biogenesis
A7K99_RS06020	COG1466	dna polymerase III delta subunit
A7K99_RS06025	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A7K99_RS06030	COG0495	leucyl-tRNA aminoacylation
A7K99_RS06035	COG1126	abc transporter atp-binding protein
A7K99_RS06040	COG0765	amino acid transport
A7K99_RS06045	COG0765	amino acid transport
A7K99_RS06055	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A7K99_RS06070	COG1702	phosphate starvation-inducible protein PhoH
A7K99_RS06080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7K99_RS06085	COG3385	transposase activity
A7K99_RS06125	COG0367	asparagine synthase
A7K99_RS06135	COG0647	UMP catabolic process
A7K99_RS06140	COG1846	Transcriptional regulator
A7K99_RS06140	COG1940	carbohydrate kinase activity
A7K99_RS06145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A7K99_RS06155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7K99_RS06155	COG1263	PTS System
A7K99_RS06155	COG2190	(PTS) system
A7K99_RS06180	COG0735	belongs to the Fur family
A7K99_RS06185	COG0716	FMN binding
A7K99_RS06195	COG0596	Alpha beta hydrolase
A7K99_RS06200	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A7K99_RS06205	COG0033	Phosphoglucomutase
A7K99_RS06210	COG3272	Protein of unknown function (DUF1722)
A7K99_RS06215	COG0415	Belongs to the DNA photolyase family
A7K99_RS06225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A7K99_RS06230	COG1984	allophanate hydrolase subunit 2
A7K99_RS06240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7K99_RS06255	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A7K99_RS06260	COG1053	succinate dehydrogenase
A7K99_RS06265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7K99_RS06270	COG0567	Dehydrogenase, E1 component
A7K99_RS06275	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7K99_RS06280	COG0045	succinate-CoA ligase (ADP-forming) activity
A7K99_RS06285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A7K99_RS06290	COG1271	oxidase subunit
A7K99_RS06295	COG1294	oxidase, subunit
A7K99_RS06300	COG4890	Cyd operon protein YbgT
A7K99_RS06305	COG3790	cyd operon protein YbgE
A7K99_RS06310	COG0824	Thioesterase
A7K99_RS06315	COG0811	peptide transport
A7K99_RS06320	COG0848	biopolymer transport protein
A7K99_RS06325	COG3064	Membrane
A7K99_RS06325	COG3064	Membrane
A7K99_RS06335	COG2885	chlorophyll binding
A7K99_RS06340	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A7K99_RS06380	COG2169	Transcriptional regulator
A7K99_RS06390	COG1230	cation diffusion facilitator family transporter
A7K99_RS06395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7K99_RS06400	COG0588	phosphoglycerate mutase activity
A7K99_RS06405	COG2017	converts alpha-aldose to the beta-anomer
A7K99_RS06415	COG1085	galactose-1-phosphate uridylyltransferase
A7K99_RS06420	COG1119	ATPase activity
A7K99_RS06425	COG2005	Transcriptional regulator
A7K99_RS06425	COG3585	molybdate ion transport
A7K99_RS06435	COG0561	phosphatase activity
A7K99_RS06445	COG1881	PFAM PEBP family protein
A7K99_RS06455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7K99_RS06470	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A7K99_RS06480	COG0556	nucleotide-excision repair
A7K99_RS06495	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7K99_RS06500	COG0315	cyclic pyranopterin monophosphate synthase activity
A7K99_RS06505	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A7K99_RS06510	COG0314	molybdopterin synthase activity
A7K99_RS06520	COG0670	Belongs to the BI1 family
A7K99_RS06535	COG0513	Belongs to the DEAD box helicase family
A7K99_RS06540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7K99_RS06545	COG0477	Major facilitator Superfamily
A7K99_RS06550	COG1376	ErfK ybiS ycfS ynhG family protein
A7K99_RS06555	COG0586	Pfam SNARE associated Golgi protein
A7K99_RS06560	COG1686	Belongs to the peptidase S11 family
A7K99_RS06565	COG3264	Mechanosensitive ion channel
A7K99_RS06565	COG1511	domain protein
A7K99_RS06570	COG1472	Belongs to the glycosyl hydrolase 3 family
A7K99_RS06580	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A7K99_RS06590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7K99_RS06595	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A7K99_RS06600	COG0783	Belongs to the Dps family
A7K99_RS06605	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A7K99_RS06610	COG3385	transposase activity
A7K99_RS06635	COG1321	iron dependent repressor
A7K99_RS06640	COG2916	Histone family protein nucleoid-structuring protein H-NS
A7K99_RS06645	COG0488	(ABC) transporter
A7K99_RS06655	COG0303	'Molybdopterin
A7K99_RS06665	COG1686	Belongs to the peptidase S11 family
A7K99_RS06670	COG0671	phosphoesterase, PA-phosphatase related
A7K99_RS06675	COG2985	domain, Protein
A7K99_RS06675	COG0569	domain protein
A7K99_RS06690	COG0778	Nitroreductase
A7K99_RS06700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A7K99_RS06705	COG3842	ATPase activity
A7K99_RS06710	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7K99_RS06715	COG1177	transmembrane transport
A7K99_RS06725	COG4160	amino acid transport
A7K99_RS06730	COG4215	(ABC) transporter
A7K99_RS06735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS06740	COG1126	abc transporter atp-binding protein
A7K99_RS06745	COG3023	N-Acetylmuramoyl-L-alanine amidase
A7K99_RS06750	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A7K99_RS06755	COG0028	Belongs to the TPP enzyme family
A7K99_RS06760	COG3593	DNA synthesis involved in DNA repair
A7K99_RS06765	COG1278	Cold shock
A7K99_RS06770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A7K99_RS06775	COG0542	response to heat
A7K99_RS06780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A7K99_RS06785	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A7K99_RS06790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A7K99_RS06795	COG4988	ABC transporter
A7K99_RS06800	COG0492	ferredoxin-NADP+ reductase activity
A7K99_RS06810	COG1674	ftsk spoiiie
A7K99_RS06810	COG3107	peptidoglycan biosynthetic process
A7K99_RS06820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A7K99_RS06855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A7K99_RS06860	COG1882	Formate acetyltransferase
A7K99_RS06865	COG2116	formate transmembrane transporter activity
A7K99_RS06870	COG1944	ATP diphosphatase activity
A7K99_RS06875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A7K99_RS06885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A7K99_RS06890	COG0539	negative regulation of cytoplasmic translation
A7K99_RS06900	COG2333	competence protein COMEC
A7K99_RS06900	COG0658	competence protein
A7K99_RS06925	COG3173	Aminoglycoside phosphotransferase
A7K99_RS06930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A7K99_RS06935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7K99_RS06940	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
A7K99_RS06945	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A7K99_RS06955	COG2989	Protein conserved in bacteria
A7K99_RS06960	COG3108	Peptidase M15
A7K99_RS06965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7K99_RS06970	COG1448	Aminotransferase
A7K99_RS06980	COG0017	Asparaginyl-tRNA synthetase
A7K99_RS06990	COG0308	aminopeptidase N
A7K99_RS06995	COG0167	dihydroorotate dehydrogenase activity
A7K99_RS07005	COG0633	Ferredoxin
A7K99_RS07005	COG3217	Mosc domain protein beta barrel domain protein
A7K99_RS07010	COG0116	Belongs to the methyltransferase superfamily
A7K99_RS07010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7K99_RS07015	COG0488	(ABC) transporter
A7K99_RS07020	COG2995	paraquat-inducible protein a
A7K99_RS07025	COG3008	intermembrane lipid transfer
A7K99_RS07025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7K99_RS07030	COG3009	Protein conserved in bacteria
A7K99_RS07035	COG3130	regulation of translation
A7K99_RS07045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7K99_RS07050	COG1067	ATP-dependent peptidase activity
A7K99_RS07055	COG3120	sequence-specific DNA binding
A7K99_RS07070	COG3070	regulator of competence-specific genes
A7K99_RS07075	COG1289	transmembrane transporter activity
A7K99_RS07080	COG3304	Inner membrane component domain
A7K99_RS07085	COG0210	DNA helicase
A7K99_RS07090	COG1803	Methylglyoxal synthase
A7K99_RS07100	COG1832	CoA-binding protein
A7K99_RS07110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7K99_RS07125	COG0670	Belongs to the BI1 family
A7K99_RS07145	COG1113	amino acid transport
A7K99_RS07155	COG2197	response regulator
A7K99_RS07165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7K99_RS07175	COG0583	DNA-binding transcription factor activity
A7K99_RS07200	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A7K99_RS07220	COG1309	transcriptional regulator
A7K99_RS07230	COG1349	DNA-binding transcription factor activity
A7K99_RS07245	COG0154	amidase activity
A7K99_RS07285	COG1464	Belongs to the NlpA lipoprotein family
A7K99_RS07300	COG1566	PFAM secretion protein HlyD family protein
A7K99_RS07315	COG1454	alcohol dehydrogenase
A7K99_RS07320	COG0656	L-ascorbic acid biosynthetic process
A7K99_RS07335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_RS07360	COG1953	Uracil, thiamine, allantoin
A7K99_RS07370	COG0477	Major facilitator Superfamily
A7K99_RS07375	COG2814	Major facilitator Superfamily
A7K99_RS07405	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A7K99_RS07420	COG0659	secondary active sulfate transmembrane transporter activity
A7K99_RS07435	COG2943	transferase activity, transferring hexosyl groups
A7K99_RS07440	COG5645	(Lipo)protein
A7K99_RS07450	COG1560	Kdo2-lipid A biosynthetic process
A7K99_RS07455	COG1054	Belongs to the UPF0176 family
A7K99_RS07480	COG0418	dihydroorotase activity
A7K99_RS07490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7K99_RS07515	COG1815	bacterial-type flagellum-dependent cell motility
A7K99_RS07520	COG1558	bacterial-type flagellum-dependent cell motility
A7K99_RS07525	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A7K99_RS07540	COG4786	Flagellar basal body rod
A7K99_RS07570	COG1530	ribonuclease E activity
A7K99_RS07575	COG0564	pseudouridine synthase activity
A7K99_RS07580	COG0366	Alpha amylase catalytic
A7K99_RS07590	COG1399	metal-binding, possibly nucleic acid-binding protein
A7K99_RS07595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A7K99_RS07605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7K99_RS07620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7K99_RS07625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7K99_RS07630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7K99_RS07635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A7K99_RS07640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7K99_RS07645	COG0470	DNA polymerase III
A7K99_RS07650	COG0084	hydrolase, TatD family'
A7K99_RS07655	COG0537	adenosine 5'-monophosphoramidase activity
A7K99_RS07660	COG5633	Lipoprotein
A7K99_RS07665	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
A7K99_RS07670	COG0510	thiamine kinase activity
A7K99_RS07680	COG1252	NADH dehydrogenase
A7K99_RS07685	COG3134	Outer membrane lipoprotein
A7K99_RS07690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A7K99_RS07695	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7K99_RS07705	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7K99_RS07710	COG1116	anion transmembrane transporter activity
A7K99_RS07715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_RS07725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_RS07730	COG3813	Protein conserved in bacteria
A7K99_RS07740	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A7K99_RS07745	COG0500	methyltransferase
A7K99_RS07750	COG3842	ATPase activity
A7K99_RS07760	COG2850	peptidyl-arginine hydroxylation
A7K99_RS07770	COG0745	RESPONSE REGULATOR receiver
A7K99_RS07775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7K99_RS07780	COG2915	High frequency lysogenization protein hflD homolog
A7K99_RS07795	COG1187	pseudouridine synthase activity
A7K99_RS07800	COG0538	isocitrate dehydrogenase activity
A7K99_RS07825	COG1902	pentaerythritol trinitrate reductase activity
A7K99_RS07850	COG0583	DNA-binding transcription factor activity
A7K99_RS07875	COG1794	racemase activity, acting on amino acids and derivatives
A7K99_RS07880	COG0583	DNA-binding transcription factor activity
A7K99_RS07910	COG3122	Protein conserved in bacteria
A7K99_RS07920	COG1683	Conserved Protein
A7K99_RS07950	COG1619	proteins homologs of microcin C7 resistance protein MccF
A7K99_RS07960	COG2261	transglycosylase associated protein
A7K99_RS07970	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A7K99_RS07975	COG3381	protein complex oligomerization
A7K99_RS07990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_RS08000	COG0814	amino acid
A7K99_RS08010	COG1918	ferrous iron import across plasma membrane
A7K99_RS08020	COG4574	serine-type endopeptidase inhibitor activity
A7K99_RS08025	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A7K99_RS08025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_RS08025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_RS08030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7K99_RS08035	COG4533	DNA binding
A7K99_RS08055	COG0754	glutathionylspermidine amidase activity
A7K99_RS08060	COG0028	Belongs to the TPP enzyme family
A7K99_RS08065	COG0679	Auxin Efflux Carrier
A7K99_RS08070	COG0484	heat shock protein binding
A7K99_RS08100	COG0583	DNA-binding transcription factor activity
A7K99_RS08115	COG0411	ABC transporter
A7K99_RS08155	COG0456	acetyltransferase
A7K99_RS08160	COG0318	PFAM AMP-dependent synthetase and ligase
A7K99_RS08170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7K99_RS08175	COG0156	8-amino-7-oxononanoate synthase activity
A7K99_RS08180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7K99_RS08185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7K99_RS08190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7K99_RS08195	COG2244	polysaccharide biosynthetic process
A7K99_RS08205	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A7K99_RS08210	COG0795	lipopolysaccharide-transporting ATPase activity
A7K99_RS08225	COG0656	L-ascorbic acid biosynthetic process
A7K99_RS08250	COG1881	PFAM PEBP family protein
A7K99_RS08255	COG1942	4-Oxalocrotonate Tautomerase
A7K99_RS08260	COG4221	oxidoreductase activity
A7K99_RS08265	COG2010	Cytochrome c
A7K99_RS08290	COG0477	Major facilitator Superfamily
A7K99_RS08295	COG1309	transcriptional regulator
A7K99_RS08300	COG0789	Transcriptional regulator
A7K99_RS08305	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A7K99_RS08310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_RS08330	COG0456	acetyltransferase
A7K99_RS08335	COG0702	epimerase
A7K99_RS08345	COG4221	oxidoreductase activity
A7K99_RS08350	COG0667	Aldo Keto reductase
A7K99_RS08355	COG0656	L-ascorbic acid biosynthetic process
A7K99_RS08375	COG2207	Transcriptional regulator
A7K99_RS08380	COG0012	GTP binding
A7K99_RS08405	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A7K99_RS08410	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A7K99_RS08420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7K99_RS08425	COG2890	protein-(glutamine-N5) methyltransferase activity
A7K99_RS08455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_RS08465	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS08470	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7K99_RS08475	COG0765	amino acid transport
A7K99_RS08480	COG0765	amino acid transport
A7K99_RS08485	COG1126	abc transporter atp-binding protein
A7K99_RS08490	COG0583	DNA-binding transcription factor activity
A7K99_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS08505	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7K99_RS08510	COG0387	Pfam Sodium calcium exchanger
A7K99_RS08515	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A7K99_RS08520	COG4932	domain protein
A7K99_RS08530	COG3138	arginine N-succinyltransferase
A7K99_RS08535	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_RS08545	COG2988	succinylglutamate desuccinylase activity
A7K99_RS08550	COG3678	ATP-independent chaperone mediated protein folding
A7K99_RS08555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A7K99_RS08560	COG2814	Major facilitator Superfamily
A7K99_RS08565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7K99_RS08575	COG1988	membrane-bound metal-dependent
A7K99_RS08580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7K99_RS08590	COG3001	Fructosamine kinase
A7K99_RS08595	COG3137	Salt-induced outer membrane protein
A7K99_RS08605	COG1802	Transcriptional regulator
A7K99_RS08615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7K99_RS08625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7K99_RS08630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7K99_RS08650	COG0776	regulation of translation
A7K99_RS08655	COG0791	NLP P60 protein
A7K99_RS08660	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A7K99_RS08665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7K99_RS08670	COG0628	permease
A7K99_RS08675	COG0277	FAD linked oxidase domain protein
A7K99_RS08675	COG0247	lactate metabolic process
A7K99_RS08685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_RS08690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS08700	COG3385	transposase activity
A7K99_RS08710	COG0366	Alpha amylase catalytic
A7K99_RS08715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7K99_RS08715	COG1263	PTS System
A7K99_RS08720	COG1609	Transcriptional regulator
A7K99_RS08745	COG0307	riboflavin synthase, alpha
A7K99_RS08750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7K99_RS08755	COG2814	Major facilitator Superfamily
A7K99_RS08760	COG0583	DNA-binding transcription factor activity
A7K99_RS08765	COG1609	Transcriptional regulator
A7K99_RS08770	COG0791	NLP P60 protein
A7K99_RS08775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A7K99_RS08785	COG0346	lactoylglutathione lyase activity
A7K99_RS08790	COG1902	pentaerythritol trinitrate reductase activity
A7K99_RS08795	COG3313	Fe-S protein
A7K99_RS08805	COG1566	PFAM secretion protein HlyD family protein
A7K99_RS08840	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A7K99_RS08860	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS08865	COG0583	DNA-binding transcription factor activity
A7K99_RS08875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7K99_RS08880	COG4660	Part of a membrane complex involved in electron transport
A7K99_RS08885	COG4659	FMN binding
A7K99_RS08890	COG4658	electron transport chain
A7K99_RS08895	COG4656	Part of a membrane complex involved in electron transport
A7K99_RS08900	COG2878	Part of a membrane complex involved in electron transport
A7K99_RS08905	COG4657	Part of a membrane complex involved in electron transport
A7K99_RS08910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A7K99_RS08920	COG5339	Protein conserved in bacteria
A7K99_RS08945	COG2207	Transcriptional regulator
A7K99_RS08945	COG3708	Transcriptional regulator
A7K99_RS08975	COG3135	benzoate transporter
A7K99_RS08980	COG1396	sequence-specific DNA binding
A7K99_RS08985	COG1335	isochorismatase
A7K99_RS08990	COG3180	Ammonia monooxygenase
A7K99_RS08995	COG4772	TonB-dependent receptor
A7K99_RS09030	COG0535	radical SAM domain protein
A7K99_RS09040	COG0277	FAD linked oxidase domain protein
A7K99_RS09050	COG2860	membrane
A7K99_RS09060	COG0625	glutathione transferase activity
A7K99_RS09070	COG3842	ATPase activity
A7K99_RS09080	COG1175	transmembrane transport
A7K99_RS09100	COG0642	Histidine kinase
A7K99_RS09105	COG0745	RESPONSE REGULATOR receiver
A7K99_RS09115	COG3727	T/G mismatch-specific endonuclease activity
A7K99_RS09130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7K99_RS09135	COG0656	L-ascorbic acid biosynthetic process
A7K99_RS09145	COG3781	membrane
A7K99_RS09155	COG3659	wide pore channel activity
A7K99_RS09160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_RS09165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7K99_RS09170	COG1120	ATPase activity
A7K99_RS09185	COG4615	Cyclic peptide transporter
A7K99_RS09215	COG1473	amidohydrolase
A7K99_RS09220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS09230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7K99_RS09240	COG2130	NADP-dependent
A7K99_RS09245	COG1309	transcriptional regulator
A7K99_RS09260	COG0583	DNA-binding transcription factor activity
A7K99_RS09280	COG0435	Glutathione S-transferase
A7K99_RS09285	COG0400	carboxylic ester hydrolase activity
A7K99_RS09330	COG2233	PERMEase
A7K99_RS09335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7K99_RS09345	COG0251	oxidation-reduction process
A7K99_RS09355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS09360	COG1309	transcriptional regulator
A7K99_RS09370	COG0778	Nitroreductase
A7K99_RS09380	COG0583	DNA-binding transcription factor activity
A7K99_RS09395	COG0519	Catalyzes the synthesis of GMP from XMP
A7K99_RS09400	COG2814	Major facilitator Superfamily
A7K99_RS09425	COG1609	Transcriptional regulator
A7K99_RS09440	COG0024	Methionine aminopeptidase
A7K99_RS09445	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7K99_RS09455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS09465	COG2271	Major facilitator Superfamily
A7K99_RS09485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7K99_RS09490	COG1414	Transcriptional regulator
A7K99_RS09515	COG0477	Major facilitator Superfamily
A7K99_RS09525	COG0583	DNA-binding transcription factor activity
A7K99_RS09535	COG1942	4-Oxalocrotonate Tautomerase
A7K99_RS09545	COG0583	DNA-binding transcription factor activity
A7K99_RS09565	COG3385	transposase activity
A7K99_RS09570	COG2010	Cytochrome c
A7K99_RS09595	COG0318	PFAM AMP-dependent synthetase and ligase
A7K99_RS09600	COG0183	Belongs to the thiolase family
A7K99_RS09630	COG3622	Belongs to the hyi family
A7K99_RS09640	COG2267	carboxylic ester hydrolase activity
A7K99_RS09660	COG2267	carboxylic ester hydrolase activity
A7K99_RS09670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_RS09680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A7K99_RS09690	COG1063	alcohol dehydrogenase
A7K99_RS09695	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS09710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7K99_RS09715	COG0076	glutamate decarboxylase activity
A7K99_RS09740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7K99_RS09745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_RS09750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7K99_RS09765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7K99_RS09770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7K99_RS09775	COG0583	DNA-binding transcription factor activity
A7K99_RS09780	COG3479	Phenolic acid decarboxylase
A7K99_RS09785	COG3385	transposase activity
A7K99_RS09810	COG3842	ATPase activity
A7K99_RS09815	COG0604	alcohol dehydrogenase
A7K99_RS09815	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS09815	COG3321	synthase
A7K99_RS09830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7K99_RS09835	COG0583	DNA-binding transcription factor activity
A7K99_RS09845	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7K99_RS09850	COG1177	transmembrane transport
A7K99_RS09855	COG2072	flavoprotein involved in K transport
A7K99_RS09860	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A7K99_RS09870	COG1309	transcriptional regulator
A7K99_RS09875	COG3177	Filamentation induced by cAMP protein fic
A7K99_RS09895	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7K99_RS09900	COG0667	Aldo Keto reductase
A7K99_RS09905	COG2068	MobA-Related Protein
A7K99_RS09910	COG1335	isochorismatase
A7K99_RS09915	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7K99_RS09920	COG0154	amidase activity
A7K99_RS09925	COG0583	DNA-binding transcription factor activity
A7K99_RS09930	COG0667	Aldo Keto reductase
A7K99_RS09935	COG1280	lysine exporter protein (LysE YggA)
A7K99_RS09945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A7K99_RS09950	COG1451	nucleotide metabolic process
A7K99_RS09960	COG2706	6-phosphogluconolactonase activity
A7K99_RS09975	COG1309	transcriptional regulator
A7K99_RS09985	COG0402	S-adenosylhomocysteine deaminase activity
A7K99_RS09990	COG4221	oxidoreductase activity
A7K99_RS10010	COG1940	carbohydrate kinase activity
A7K99_RS10015	COG0583	DNA-binding transcription factor activity
A7K99_RS10020	COG2814	Major facilitator Superfamily
A7K99_RS10025	COG3038	cytochrome b561
A7K99_RS10035	COG3422	double-strand break repair
A7K99_RS10040	COG0583	DNA-binding transcription factor activity
A7K99_RS10045	COG2840	Smr protein MutS2
A7K99_RS10050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7K99_RS10065	COG0531	amino acid
A7K99_RS10075	COG0745	RESPONSE REGULATOR receiver
A7K99_RS10080	COG2205	protein histidine kinase activity
A7K99_RS10095	COG3591	Belongs to the peptidase S1B family
A7K99_RS10100	COG1643	Atp-dependent helicase
A7K99_RS10115	COG2911	Protein conserved in bacteria
A7K99_RS10120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7K99_RS10145	COG4166	transmembrane transport
A7K99_RS10150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A7K99_RS10160	COG3768	UPF0283 membrane protein
A7K99_RS10165	COG3106	COG3106 Predicted ATPase
A7K99_RS10175	COG1983	PspC domain protein
A7K99_RS10185	COG1842	Phage shock protein A
A7K99_RS10190	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A7K99_RS10195	COG4166	transmembrane transport
A7K99_RS10200	COG4168	peptide transport system, permease
A7K99_RS10205	COG4171	peptide transport system, permease
A7K99_RS10220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A7K99_RS10230	COG0583	DNA-binding transcription factor activity
A7K99_RS10240	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A7K99_RS10250	COG0023	Translation Initiation Factor
A7K99_RS10260	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A7K99_RS10265	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A7K99_RS10270	COG0671	phosphoesterase, PA-phosphatase related
A7K99_RS10280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A7K99_RS10305	COG0616	signal peptide processing
A7K99_RS10310	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS10320	COG0009	L-threonylcarbamoyladenylate synthase
A7K99_RS10325	COG0613	PHP domain protein
A7K99_RS10335	COG0512	Glutamine amidotransferase of anthranilate synthase
A7K99_RS10335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7K99_RS10340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7K99_RS10355	COG0159	tryptophan synthase activity
A7K99_RS10365	COG3047	cAMP biosynthetic process
A7K99_RS10375	COG2917	probably involved in intracellular septation
A7K99_RS10390	COG2350	Protein conserved in bacteria
A7K99_RS10415	COG3099	Belongs to the UPF0263 family
A7K99_RS10420	COG1454	alcohol dehydrogenase
A7K99_RS10420	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_RS10430	COG1435	thymidine kinase activity
A7K99_RS10445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A7K99_RS10450	COG0745	RESPONSE REGULATOR receiver
A7K99_RS10460	COG0788	formyltetrahydrofolate deformylase activity
A7K99_RS10490	COG0708	Exodeoxyribonuclease III
A7K99_RS10500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7K99_RS10505	COG0778	Nitroreductase
A7K99_RS10510	COG0616	signal peptide processing
A7K99_RS10515	COG0252	asparaginase activity
A7K99_RS10520	COG3139	Protein of unknown function (DUF1315)
A7K99_RS10540	COG3713	MltA-interacting MipA family protein
A7K99_RS10550	COG2766	serine protein kinase
A7K99_RS10555	COG2718	Belongs to the UPF0229 family
A7K99_RS10575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A7K99_RS10580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_RS10585	COG2719	SpoVR family
A7K99_RS10605	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7K99_RS10610	COG3100	YcgL domain-containing protein
A7K99_RS10615	COG0850	regulation of cytokinetic process
A7K99_RS10620	COG2894	cell division
A7K99_RS10625	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A7K99_RS10630	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A7K99_RS10635	COG0318	PFAM AMP-dependent synthetase and ligase
A7K99_RS10640	COG3065	identical protein binding
A7K99_RS10650	COG1199	ATP-dependent helicase activity
A7K99_RS10655	COG0251	oxidation-reduction process
A7K99_RS10675	COG1760	l-serine dehydratase
A7K99_RS10680	COG1253	flavin adenine dinucleotide binding
A7K99_RS10685	COG2226	methyltransferase
A7K99_RS10710	COG0501	Belongs to the peptidase M48B family
A7K99_RS10720	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A7K99_RS10725	COG1956	GAF domain-containing protein
A7K99_RS10730	COG2995	paraquat-inducible protein a
A7K99_RS10735	COG3008	intermembrane lipid transfer
A7K99_RS10740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7K99_RS10740	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A7K99_RS10750	COG1276	copper resistance
A7K99_RS10760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7K99_RS10765	COG1770	oligopeptidase
A7K99_RS10770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A7K99_RS10785	COG0583	DNA-binding transcription factor activity
A7K99_RS10790	COG4774	siderophore transport
A7K99_RS10800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7K99_RS10805	COG0469	pyruvate kinase activity
A7K99_RS10810	COG1560	Kdo2-lipid A biosynthetic process
A7K99_RS10815	COG0739	heme binding
A7K99_RS10820	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A7K99_RS10830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7K99_RS10835	COG2255	four-way junction helicase activity
A7K99_RS10840	COG0632	four-way junction helicase activity
A7K99_RS10850	COG0217	transcriptional regulatory protein
A7K99_RS10855	COG0494	nUDIX hydrolase
A7K99_RS10860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7K99_RS10865	COG1801	Protein of unknown function DUF72
A7K99_RS10875	COG0500	methyltransferase
A7K99_RS10880	COG3142	Participates in the control of copper homeostasis
A7K99_RS10885	COG3102	Protein conserved in bacteria
A7K99_RS10900	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7K99_RS10910	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A7K99_RS10915	COG0745	RESPONSE REGULATOR receiver
A7K99_RS10925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A7K99_RS10935	COG0835	chemotaxis
A7K99_RS10940	COG0643	Histidine kinase
A7K99_RS10940	COG2198	Histidine kinase
A7K99_RS10945	COG1360	Flagellar Motor Protein
A7K99_RS10980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7K99_RS11000	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7K99_RS11010	COG3069	C4-dicarboxylate transmembrane transporter activity
A7K99_RS11020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7K99_RS11040	COG1702	phosphate starvation-inducible protein PhoH
A7K99_RS11045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7K99_RS11050	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A7K99_RS11050	COG0506	proline dehydrogenase activity
A7K99_RS11050	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A7K99_RS11065	COG0583	DNA-binding transcription factor activity
A7K99_RS11075	COG1191	sigma factor activity
A7K99_RS11100	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A7K99_RS11125	COG2207	Transcriptional regulator
A7K99_RS11130	COG2113	Glycine betaine
A7K99_RS11145	COG1677	Flagellar hook-basal body complex protein FliE
A7K99_RS11155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A7K99_RS11160	COG1317	bacterial-type flagellum organization
A7K99_RS11165	COG1157	protein secretion by the type III secretion system
A7K99_RS11180	COG1580	Controls the rotational direction of flagella during chemotaxis
A7K99_RS11200	COG1338	Plays a role in the flagellum-specific transport system
A7K99_RS11210	COG1684	flagellar biosynthetic protein fliR
A7K99_RS11225	COG2354	Protein conserved in bacteria
A7K99_RS11235	COG1418	mRNA catabolic process
A7K99_RS11240	COG0477	Major facilitator Superfamily
A7K99_RS11250	COG1121	(ABC) transporter
A7K99_RS11265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A7K99_RS11275	COG3384	dioxygenase
A7K99_RS11285	COG0583	DNA-binding transcription factor activity
A7K99_RS11295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A7K99_RS11300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7K99_RS11305	COG2828	Protein conserved in bacteria
A7K99_RS11345	COG2963	transposase activity
A7K99_RS11355	COG1959	2 iron, 2 sulfur cluster binding
A7K99_RS11370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7K99_RS11375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7K99_RS11380	COG0583	DNA-binding transcription factor activity
A7K99_RS11385	COG0640	Transcriptional regulator
A7K99_RS11400	COG2814	Major facilitator Superfamily
A7K99_RS11425	COG0477	Major facilitator Superfamily
A7K99_RS11430	COG2186	Transcriptional regulator
A7K99_RS11450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7K99_RS11450	COG0189	ligase activity
A7K99_RS11455	COG1902	pentaerythritol trinitrate reductase activity
A7K99_RS11460	COG3684	Belongs to the aldolase LacD family
A7K99_RS11465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_RS11465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_RS11465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_RS11475	COG1349	DNA-binding transcription factor activity
A7K99_RS11480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_RS11495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7K99_RS11525	COG0583	DNA-binding transcription factor activity
A7K99_RS11540	COG1902	pentaerythritol trinitrate reductase activity
A7K99_RS11545	COG0596	Alpha beta hydrolase
A7K99_RS11590	COG0583	DNA-binding transcription factor activity
A7K99_RS11595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7K99_RS11600	COG2851	Citrate transporter
A7K99_RS11610	COG1174	glycine betaine transport
A7K99_RS11615	COG1174	glycine betaine transport
A7K99_RS11625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS11650	COG2814	Major facilitator Superfamily
A7K99_RS11665	COG4773	Receptor
A7K99_RS11670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_RS11675	COG2814	Major facilitator Superfamily
A7K99_RS11685	COG0656	L-ascorbic acid biosynthetic process
A7K99_RS11720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_RS11730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_RS11750	COG1881	PFAM PEBP family protein
A7K99_RS11755	COG2207	Transcriptional regulator
A7K99_RS11805	COG0656	L-ascorbic acid biosynthetic process
A7K99_RS11810	COG0656	L-ascorbic acid biosynthetic process
A7K99_RS11830	COG1064	alcohol dehydrogenase
A7K99_RS11835	COG0656	L-ascorbic acid biosynthetic process
A7K99_RS11840	COG0667	Aldo Keto reductase
A7K99_RS11875	COG2223	nitrite transmembrane transporter activity
A7K99_RS11885	COG4221	oxidoreductase activity
A7K99_RS11890	COG0477	Major facilitator Superfamily
A7K99_RS11910	COG0583	DNA-binding transcription factor activity
A7K99_RS11935	COG1403	HNH endonuclease
A7K99_RS11950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7K99_RS11955	COG1454	alcohol dehydrogenase
A7K99_RS11960	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_RS11975	COG2199	diguanylate cyclase activity
A7K99_RS11975	COG2203	Gaf domain
A7K99_RS12010	COG2207	Transcriptional regulator
A7K99_RS12020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7K99_RS12020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_RS12020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_RS12025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_RS12030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_RS12035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_RS12060	COG0243	molybdopterin cofactor binding
A7K99_RS12065	COG3189	MarR family transcriptional regulator
A7K99_RS12070	COG0765	amino acid transport
A7K99_RS12075	COG1126	abc transporter atp-binding protein
A7K99_RS12080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS12090	COG0583	DNA-binding transcription factor activity
A7K99_RS12095	COG2116	formate transmembrane transporter activity
A7K99_RS12100	COG0625	glutathione transferase activity
A7K99_RS12105	COG2188	Transcriptional regulator
A7K99_RS12110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_RS12115	COG1397	ADP-ribosylglycohydrolase
A7K99_RS12120	COG2211	Major facilitator Superfamily
A7K99_RS12125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7K99_RS12125	COG2010	Cytochrome c
A7K99_RS12130	COG2080	2 iron, 2 sulfur cluster binding
A7K99_RS12135	COG1846	Transcriptional regulator
A7K99_RS12140	COG2271	Major facilitator Superfamily
A7K99_RS12145	COG2233	PERMEase
A7K99_RS12150	COG1335	isochorismatase
A7K99_RS12155	COG3473	Maleate cis-trans isomerase
A7K99_RS12160	COG0596	Alpha beta hydrolase
A7K99_RS12165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7K99_RS12170	COG2309	aminopeptidase activity
A7K99_RS12175	COG3608	succinylglutamate desuccinylase aspartoacylase
A7K99_RS12175	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A7K99_RS12180	COG0523	cobalamin synthesis protein
A7K99_RS12185	COG3300	MHYT domain
A7K99_RS12185	COG5001	Diguanylate cyclase
A7K99_RS12190	COG0534	Mate efflux family protein
A7K99_RS12195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7K99_RS12200	COG2252	PERMEase
A7K99_RS12220	COG0765	amino acid transport
A7K99_RS12225	COG1126	abc transporter atp-binding protein
A7K99_RS12250	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
A7K99_RS12255	COG0583	DNA-binding transcription factor activity
A7K99_RS12270	COG0251	oxidation-reduction process
A7K99_RS12290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_RS12310	COG0371	Dehydrogenase
A7K99_RS12330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS12340	COG0765	amino acid transport
A7K99_RS12345	COG0165	Argininosuccinate lyase
A7K99_RS12355	COG1802	Transcriptional regulator
A7K99_RS12380	COG2814	Major facilitator Superfamily
A7K99_RS12390	COG2072	flavoprotein involved in K transport
A7K99_RS12400	COG2144	transferase activity, transferring acyl groups
A7K99_RS12425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_RS12430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7K99_RS12435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7K99_RS12455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7K99_RS12460	COG1045	serine acetyltransferase
A7K99_RS12465	COG1116	anion transmembrane transporter activity
A7K99_RS12470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_RS12500	COG4771	TonB-dependent receptor
A7K99_RS12535	COG1070	Carbohydrate kinase
A7K99_RS12540	COG0583	DNA-binding transcription factor activity
A7K99_RS12550	COG4773	Receptor
A7K99_RS12560	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_RS12580	COG4206	TonB-dependent receptor
A7K99_RS12580	COG1629	transport
A7K99_RS12590	COG0667	Aldo Keto reductase
A7K99_RS12605	COG0583	DNA-binding transcription factor activity
A7K99_RS12610	COG0477	Major facilitator Superfamily
A7K99_RS12630	COG1120	ATPase activity
A7K99_RS12635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_RS12640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_RS12645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7K99_RS12680	COG1414	Transcriptional regulator
A7K99_RS12700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7K99_RS12705	COG2211	Major facilitator Superfamily
A7K99_RS12710	COG3940	Belongs to the glycosyl hydrolase 43 family
A7K99_RS12715	COG2271	Major facilitator Superfamily
A7K99_RS12735	COG0390	transport system, permease component
A7K99_RS12740	COG4619	ABC transporter
A7K99_RS12745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A7K99_RS12750	COG2926	Belongs to the UPF0265 family
A7K99_RS12755	COG1289	transmembrane transporter activity
A7K99_RS12770	COG0640	Transcriptional regulator
A7K99_RS12920	COG3728	DNA packaging
A7K99_RS12945	COG3772	lysozyme
A7K99_RS12955	COG0484	heat shock protein binding
A7K99_RS13080	COG4712	double-strand break repair protein
A7K99_RS13145	COG0582	viral genome integration into host DNA
A7K99_RS13150	COG2925	Exonuclease
A7K99_RS13155	COG0531	amino acid
A7K99_RS13160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7K99_RS13165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A7K99_RS13175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7K99_RS13180	COG0131	Imidazoleglycerol-phosphate dehydratase
A7K99_RS13180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7K99_RS13190	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A7K99_RS13200	COG0140	phosphoribosyl-ATP diphosphatase activity
A7K99_RS13200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A7K99_RS13210	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7K99_RS13220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7K99_RS13220	COG1263	PTS System
A7K99_RS13220	COG2190	(PTS) system
A7K99_RS13225	COG2723	6-phospho-beta-galactosidase activity
A7K99_RS13305	COG2982	Protein involved in outer membrane biogenesis
A7K99_RS13325	COG0443	Heat shock 70 kDa protein
A7K99_RS13330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_RS13340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7K99_RS13350	COG2205	protein histidine kinase activity
A7K99_RS13355	COG0745	RESPONSE REGULATOR receiver
A7K99_RS13360	COG0826	peptidase U32
A7K99_RS13365	COG1597	lipid kinase activity
A7K99_RS13370	COG0351	phosphomethylpyrimidine kinase
A7K99_RS13385	COG0513	Belongs to the DEAD box helicase family
A7K99_RS13405	COG3634	alkyl hydroperoxide reductase activity
A7K99_RS13420	COG0489	protein tyrosine kinase activity
A7K99_RS13425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7K99_RS13425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7K99_RS13430	COG0295	cytidine deaminase activity
A7K99_RS13435	COG0281	malic enzyme
A7K99_RS13440	COG2949	membrane
A7K99_RS13460	COG2311	Membrane
A7K99_RS13470	COG0583	DNA-binding transcription factor activity
A7K99_RS13480	COG0833	amino acid
A7K99_RS13485	COG0583	DNA-binding transcription factor activity
A7K99_RS13490	COG2855	membrane
A7K99_RS13500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_RS13500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_RS13500	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A7K99_RS13505	COG1105	Belongs to the carbohydrate kinase PfkB family
A7K99_RS13510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_RS13510	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_RS13520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7K99_RS13525	COG0671	phosphoesterase, PA-phosphatase related
A7K99_RS13530	COG3385	transposase activity
A7K99_RS13535	COG0531	amino acid
A7K99_RS13545	COG0791	NLP P60 protein
A7K99_RS13555	COG2814	Major facilitator Superfamily
A7K99_RS13560	COG1187	pseudouridine synthase activity
A7K99_RS13565	COG1061	Type III restriction enzyme res subunit
A7K99_RS13570	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A7K99_RS13580	COG3082	Protein of unknown function (DUF1414)
A7K99_RS13585	COG3083	sulfuric ester hydrolase activity
A7K99_RS13600	COG3619	membrane
A7K99_RS13605	COG2259	Doxx family
A7K99_RS13610	COG0583	DNA-binding transcription factor activity
A7K99_RS13650	COG2198	Histidine kinase
A7K99_RS13650	COG0642	Histidine kinase
A7K99_RS13655	COG2197	response regulator
A7K99_RS13660	COG2205	protein histidine kinase activity
A7K99_RS13660	COG0784	Response regulator, receiver
A7K99_RS13670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7K99_RS13675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7K99_RS13685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7K99_RS13710	COG2153	protein acetylation
A7K99_RS13715	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS13725	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7K99_RS13730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7K99_RS13735	COG0713	ATP synthesis coupled electron transport
A7K99_RS13740	COG0839	Belongs to the complex I subunit 6 family
A7K99_RS13750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A7K99_RS13760	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A7K99_RS13770	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7K99_RS13770	COG0649	NAD binding
A7K99_RS13785	COG0583	DNA-binding transcription factor activity
A7K99_RS13790	COG0436	Aminotransferase
A7K99_RS13795	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A7K99_RS13800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7K99_RS13805	COG3092	negative regulation of chromosome organization
A7K99_RS13815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7K99_RS13820	COG0857	belongs to the CobB CobQ family
A7K99_RS13820	COG0280	phosphate acetyltransferase
A7K99_RS13830	COG0625	glutathione transferase activity
A7K99_RS13840	COG4160	amino acid transport
A7K99_RS13845	COG4215	(ABC) transporter
A7K99_RS13855	COG0163	prenyltransferase activity
A7K99_RS13860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A7K99_RS13865	COG1286	toxin biosynthetic process
A7K99_RS13870	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A7K99_RS13875	COG0285	dihydrofolate synthase activity
A7K99_RS13885	COG0586	Pfam SNARE associated Golgi protein
A7K99_RS13890	COG0101	tRNA pseudouridine synthase activity
A7K99_RS13895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A7K99_RS13930	COG1473	amidohydrolase
A7K99_RS13935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7K99_RS13950	COG3101	peptidyl-lysine hydroxylation
A7K99_RS13955	COG0730	response to heat
A7K99_RS13965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A7K99_RS13975	COG2840	Smr protein MutS2
A7K99_RS13980	COG2062	phosphohistidine phosphatase, SixA
A7K99_RS13990	COG0183	Belongs to the thiolase family
A7K99_RS13995	COG3691	Protein conserved in bacteria
A7K99_RS14025	COG1138	Cytochrome C-type biogenesis protein
A7K99_RS14035	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7K99_RS14040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7K99_RS14045	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7K99_RS14055	COG2116	formate transmembrane transporter activity
A7K99_RS14060	COG0583	DNA-binding transcription factor activity
A7K99_RS14090	COG0058	SHG alpha-glucan phosphorylase activity
A7K99_RS14095	COG0297	glycogen (starch) synthase activity
A7K99_RS14100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A7K99_RS14105	COG1523	belongs to the glycosyl hydrolase 13 family
A7K99_RS14110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A7K99_RS14120	COG2390	Transcriptional regulator
A7K99_RS14125	COG0149	triose-phosphate isomerase activity
A7K99_RS14130	COG2376	Dihydroxyacetone kinase
A7K99_RS14135	COG0698	ribose 5-phosphate isomerase
A7K99_RS14145	COG2271	Major facilitator Superfamily
A7K99_RS14150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7K99_RS14160	COG4122	O-methyltransferase activity
A7K99_RS14180	COG0531	amino acid
A7K99_RS14185	COG0531	amino acid
A7K99_RS14190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A7K99_RS14190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_RS14205	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_RS14215	COG0322	excinuclease ABC activity
A7K99_RS14220	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A7K99_RS14225	COG4988	ABC transporter
A7K99_RS14235	COG1271	oxidase subunit
A7K99_RS14265	COG2223	nitrite transmembrane transporter activity
A7K99_RS14290	COG0436	Aminotransferase
A7K99_RS14295	COG3275	phosphorelay sensor kinase activity
A7K99_RS14300	COG3279	Response regulator of the LytR AlgR family
A7K99_RS14305	COG0837	glucose binding
A7K99_RS14315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A7K99_RS14325	COG0628	permease
A7K99_RS14340	COG3415	Transposase
A7K99_RS14345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7K99_RS14385	COG0673	inositol 2-dehydrogenase activity
A7K99_RS14390	COG1349	DNA-binding transcription factor activity
A7K99_RS14410	COG0583	DNA-binding transcription factor activity
A7K99_RS14415	COG0385	Bile acid
A7K99_RS14420	COG1566	PFAM secretion protein HlyD family protein
A7K99_RS14425	COG2814	Major facilitator Superfamily
A7K99_RS14435	COG3530	Putative quorum-sensing-regulated virulence factor
A7K99_RS14445	COG3115	cell septum assembly
A7K99_RS14475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7K99_RS14480	COG0463	Glycosyl transferase, family 2
A7K99_RS14490	COG0726	polysaccharide deacetylase
A7K99_RS14495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7K99_RS14505	COG2076	Multidrug Resistance protein
A7K99_RS14510	COG2205	protein histidine kinase activity
A7K99_RS14515	COG0745	RESPONSE REGULATOR receiver
A7K99_RS14520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7K99_RS14530	COG4208	sulfate ABC transporter
A7K99_RS14535	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A7K99_RS14545	COG2837	iron assimilation
A7K99_RS14560	COG0456	acetyltransferase
A7K99_RS14575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7K99_RS14580	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7K99_RS14585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7K99_RS14600	COG1393	Belongs to the ArsC family
A7K99_RS14605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_RS14615	COG0400	carboxylic ester hydrolase activity
A7K99_RS14625	COG2321	neutral zinc metallopeptidase
A7K99_RS14635	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A7K99_RS14645	COG2716	regulation of RNA biosynthetic process
A7K99_RS14650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A7K99_RS14655	COG4783	chaperone-mediated protein folding
A7K99_RS14660	COG1393	Belongs to the ArsC family
A7K99_RS14670	COG2233	PERMEase
A7K99_RS14685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A7K99_RS14690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A7K99_RS14695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A7K99_RS14705	COG0500	methyltransferase
A7K99_RS14710	COG2239	Acts as a magnesium transporter
A7K99_RS14715	COG4993	Dehydrogenase
A7K99_RS14755	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
A7K99_RS14760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A7K99_RS14770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7K99_RS14775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7K99_RS14790	COG0477	Major facilitator Superfamily
A7K99_RS14800	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS14815	COG0300	oxidoreductase activity
A7K99_RS14820	COG2207	Transcriptional regulator
A7K99_RS14825	COG2706	6-phosphogluconolactonase activity
A7K99_RS14870	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A7K99_RS14880	COG0386	Belongs to the glutathione peroxidase family
A7K99_RS14895	COG0516	GMP reductase activity
A7K99_RS14895	COG0517	IMP dehydrogenase activity
A7K99_RS14900	COG1570	exodeoxyribonuclease VII activity
A7K99_RS14910	COG1645	bacterial-type flagellum-dependent swarming motility
A7K99_RS14915	COG1160	GTP binding
A7K99_RS14920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7K99_RS14925	COG2976	Protein conserved in bacteria
A7K99_RS14930	COG0124	histidyl-tRNA synthetase
A7K99_RS14935	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A7K99_RS14955	COG0105	UTP biosynthetic process
A7K99_RS14960	COG2897	thiosulfate sulfurtransferase activity
A7K99_RS14975	COG2975	iron-sulfur cluster assembly
A7K99_RS14980	COG0633	Ferredoxin
A7K99_RS14990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A7K99_RS15000	COG0822	iron-sulfur transferase activity
A7K99_RS15010	COG1959	2 iron, 2 sulfur cluster binding
A7K99_RS15020	COG0483	inositol monophosphate 1-phosphatase activity
A7K99_RS15025	COG3711	transcriptional antiterminator
A7K99_RS15030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7K99_RS15035	COG1017	nitric oxide dioxygenase activity
A7K99_RS15035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7K99_RS15040	COG0347	Belongs to the P(II) protein family
A7K99_RS15045	COG2204	response regulator
A7K99_RS15055	COG2205	protein histidine kinase activity
A7K99_RS15060	COG3385	transposase activity
A7K99_RS15065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7K99_RS15065	COG0047	phosphoribosylformylglycinamidine synthase activity
A7K99_RS15070	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A7K99_RS15105	COG0560	Phosphoserine phosphatase
A7K99_RS15115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7K99_RS15120	COG0736	holo-[acyl-carrier-protein] synthase activity
A7K99_RS15125	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A7K99_RS15140	COG0571	ribonuclease III activity
A7K99_RS15150	COG0481	GTPase activity
A7K99_RS15155	COG3086	response to oxidative stress
A7K99_RS15175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A7K99_RS15180	COG0513	Belongs to the DEAD box helicase family
A7K99_RS15185	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A7K99_RS15195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7K99_RS15200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A7K99_RS15205	COG0497	DNA recombination
A7K99_RS15210	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7K99_RS15215	COG2914	Belongs to the UPF0125 (RnfH) family
A7K99_RS15220	COG2867	negative regulation of translational initiation
A7K99_RS15260	COG3210	domain, Protein
A7K99_RS15270	COG3210	domain, Protein
A7K99_RS15280	COG3210	domain, Protein
A7K99_RS15285	COG2831	hemolysin activation secretion protein
A7K99_RS15310	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7K99_RS15330	COG3775	system Galactitol-specific IIC component
A7K99_RS15345	COG2199	diguanylate cyclase activity
A7K99_RS15350	COG2885	chlorophyll binding
A7K99_RS15355	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS15360	COG1733	regulation of RNA biosynthetic process
A7K99_RS15370	COG0702	epimerase
A7K99_RS15380	COG4149	molybdate abc transporter
A7K99_RS15385	COG0725	ABC transporter, periplasmic molybdate-binding protein
A7K99_RS15390	COG0789	Transcriptional regulator
A7K99_RS15420	COG2226	methyltransferase
A7K99_RS15425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7K99_RS15430	COG1388	LysM domain
A7K99_RS15430	COG0741	lytic transglycosylase activity
A7K99_RS15435	COG3021	interspecies interaction between organisms
A7K99_RS15440	COG2814	Major facilitator Superfamily
A7K99_RS15445	COG0583	DNA-binding transcription factor activity
A7K99_RS15455	COG4521	taurine ABC transporter
A7K99_RS15465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_RS15470	COG2175	clavaminate synthase activity
A7K99_RS15475	COG2814	Major facilitator Superfamily
A7K99_RS15510	COG0542	response to heat
A7K99_RS15515	COG1496	oxidoreductase activity
A7K99_RS15525	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7K99_RS15530	COG3385	transposase activity
A7K99_RS15535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A7K99_RS15540	COG0077	Prephenate dehydratase
A7K99_RS15540	COG1605	Chorismate mutase
A7K99_RS15545	COG1605	Chorismate mutase
A7K99_RS15545	COG0287	Prephenate dehydrogenase
A7K99_RS15550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7K99_RS15560	COG0436	Aminotransferase
A7K99_RS15565	COG0583	DNA-binding transcription factor activity
A7K99_RS15580	COG0765	amino acid transport
A7K99_RS15585	COG1126	abc transporter atp-binding protein
A7K99_RS15605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A7K99_RS15615	COG1073	alpha beta
A7K99_RS15620	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A7K99_RS15625	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7K99_RS15640	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_RS15650	COG3034	peptidoglycan biosynthetic process
A7K99_RS15655	COG0121	glutamine amidotransferase
A7K99_RS15665	COG1960	acyl-CoA dehydrogenase activity
A7K99_RS15680	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A7K99_RS15685	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A7K99_RS15690	COG0436	Aminotransferase
A7K99_RS15695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7K99_RS15700	COG2351	hydroxyisourate hydrolase activity
A7K99_RS15715	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7K99_RS15755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7K99_RS15765	COG4575	ribosome binding
A7K99_RS15775	COG1780	Probably involved in ribonucleotide reductase function
A7K99_RS15780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7K99_RS15785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7K99_RS15790	COG4175	Glycine betaine
A7K99_RS15795	COG4176	ABC-type proline glycine betaine transport system permease component
A7K99_RS15805	COG1846	Transcriptional regulator
A7K99_RS15810	COG1566	PFAM secretion protein HlyD family protein
A7K99_RS15815	COG2814	Major facilitator Superfamily
A7K99_RS15820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7K99_RS15825	COG3118	belongs to the thioredoxin family
A7K99_RS15830	COG3148	PFAM DTW domain containing protein
A7K99_RS15835	COG0045	succinate-CoA ligase (ADP-forming) activity
A7K99_RS15835	COG1042	CoA-binding domain protein
A7K99_RS15835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7K99_RS15840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7K99_RS15855	COG0477	Major facilitator Superfamily
A7K99_RS15885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7K99_RS15895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7K99_RS15900	COG2011	ABC-type metal ion transport system permease component
A7K99_RS15915	COG1720	tRNA m6t6A37 methyltransferase activity
A7K99_RS15920	COG0442	prolyl-tRNA aminoacylation
A7K99_RS15930	COG4681	YaeQ
A7K99_RS15935	COG4568	rho-dependent transcription termination
A7K99_RS15940	COG0037	tRNA processing
A7K99_RS15945	COG0346	lactoylglutathione lyase activity
A7K99_RS15950	COG0825	malonyl-CoA metabolic process
A7K99_RS15955	COG0587	DNA-directed DNA polymerase activity
A7K99_RS15960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A7K99_RS15965	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7K99_RS15975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7K99_RS15985	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A7K99_RS15990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7K99_RS16000	COG0575	Belongs to the CDS family
A7K99_RS16005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7K99_RS16010	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A7K99_RS16015	COG0233	cytoplasmic translational termination
A7K99_RS16020	COG0528	UMP kinase activity
A7K99_RS16025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7K99_RS16040	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A7K99_RS16055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7K99_RS16065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7K99_RS16070	COG0316	Belongs to the HesB IscA family
A7K99_RS16085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7K99_RS16090	COG1643	Atp-dependent helicase
A7K99_RS16100	COG1489	DNA binding
A7K99_RS16105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A7K99_RS16120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A7K99_RS16125	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A7K99_RS16130	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A7K99_RS16135	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A7K99_RS16140	COG0842	Transport permease protein
A7K99_RS16145	COG1131	(ABC) transporter
A7K99_RS16150	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A7K99_RS16165	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A7K99_RS16170	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A7K99_RS16195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7K99_RS16200	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7K99_RS16205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A7K99_RS16210	COG2186	Transcriptional regulator
A7K99_RS16220	COG3725	Membrane protein required for beta-lactamase induction
A7K99_RS16225	COG3023	N-Acetylmuramoyl-L-alanine amidase
A7K99_RS16235	COG4969	Belongs to the N-Me-Phe pilin family
A7K99_RS16240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7K99_RS16245	COG1459	type II secretion system
A7K99_RS16250	COG0516	GMP reductase activity
A7K99_RS16255	COG0237	dephospho-CoA kinase activity
A7K99_RS16265	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A7K99_RS16270	COG0494	nUDIX hydrolase
A7K99_RS16285	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A7K99_RS16290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A7K99_RS16295	COG0849	cell division
A7K99_RS16305	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7K99_RS16315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7K99_RS16320	COG0772	Belongs to the SEDS family
A7K99_RS16335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7K99_RS16340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7K99_RS16345	COG0768	penicillin binding
A7K99_RS16350	COG3116	cell division
A7K99_RS16355	COG0275	rRNA processing
A7K99_RS16360	COG2001	Belongs to the MraZ family
A7K99_RS16365	COG1609	Transcriptional regulator
A7K99_RS16375	COG0028	Belongs to the TPP enzyme family
A7K99_RS16380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7K99_RS16390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7K99_RS16395	COG0066	3-isopropylmalate dehydratase activity
A7K99_RS16400	COG2814	Major facilitator Superfamily
A7K99_RS16410	COG4143	(ABC) transporter
A7K99_RS16415	COG1178	ABC-type Fe3 transport system permease component
A7K99_RS16425	COG0586	Pfam SNARE associated Golgi protein
A7K99_RS16430	COG0417	DNA replication proofreading
A7K99_RS16435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7K99_RS16440	COG0564	pseudouridine synthase activity
A7K99_RS16445	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A7K99_RS16460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A7K99_RS16465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A7K99_RS16470	COG2967	ApaG domain
A7K99_RS16475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A7K99_RS16480	COG2723	6-phospho-beta-galactosidase activity
A7K99_RS16505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A7K99_RS16510	COG0505	Belongs to the CarA family
A7K99_RS16515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7K99_RS16520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A7K99_RS16525	COG1047	Peptidyl-prolyl cis-trans
A7K99_RS16530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7K99_RS16535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A7K99_RS16540	COG0196	riboflavin kinase activity
A7K99_RS16545	COG0268	Binds directly to 16S ribosomal RNA
A7K99_RS16570	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7K99_RS16575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7K99_RS16585	COG4319	ketosteroid isomerase
A7K99_RS16600	COG0460	homoserine dehydrogenase
A7K99_RS16600	COG0527	aspartate kinase activity
A7K99_RS16610	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A7K99_RS16615	COG0745	RESPONSE REGULATOR receiver
A7K99_RS16620	COG3045	CreA protein
A7K99_RS16625	COG2207	Transcriptional regulator
A7K99_RS16625	COG3708	Transcriptional regulator
A7K99_RS16635	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A7K99_RS16645	COG0741	lytic transglycosylase activity
A7K99_RS16655	COG0439	Biotin carboxylase
A7K99_RS16670	COG0559	Belongs to the binding-protein-dependent transport system permease family
A7K99_RS16700	COG0697	spore germination
A7K99_RS16705	COG0488	(ABC) transporter
A7K99_RS16720	COG0560	Phosphoserine phosphatase
A7K99_RS16725	COG3726	membrane protein affecting hemolysin expression
A7K99_RS16735	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_RS16745	COG0583	DNA-binding transcription factor activity
A7K99_RS16750	COG1011	Hydrolase
A7K99_RS16755	COG0456	acetyltransferase
A7K99_RS16760	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A7K99_RS16795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A7K99_RS16800	COG2814	Major facilitator Superfamily
A7K99_RS16810	COG5455	response to cobalt ion
A7K99_RS16845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS16855	COG0456	acetyltransferase
A7K99_RS16860	COG1473	amidohydrolase
A7K99_RS16865	COG2079	MmgE PrpD family protein
A7K99_RS16875	COG1126	abc transporter atp-binding protein
A7K99_RS16890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7K99_RS16900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS16905	COG1126	abc transporter atp-binding protein
A7K99_RS16910	COG0583	DNA-binding transcription factor activity
A7K99_RS16915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_RS16940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7K99_RS16950	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_RS16955	COG0463	Glycosyl transferase, family 2
A7K99_RS16970	COG4774	siderophore transport
A7K99_RS16980	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7K99_RS16985	COG2199	diguanylate cyclase activity
A7K99_RS16990	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A7K99_RS17000	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7K99_RS17000	COG1902	pentaerythritol trinitrate reductase activity
A7K99_RS17005	COG2813	Specifically methylates the guanine in position
A7K99_RS17010	COG0038	chloride channel
A7K99_RS17015	COG0861	Integral membrane protein TerC family
A7K99_RS17025	COG0586	Pfam SNARE associated Golgi protein
A7K99_RS17035	COG1422	Protein of unknown function (DUF1090)
A7K99_RS17040	COG4575	ribosome binding
A7K99_RS17045	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A7K99_RS17055	COG0435	Glutathione S-transferase
A7K99_RS17060	COG0583	DNA-binding transcription factor activity
A7K99_RS17065	COG1741	Belongs to the pirin family
A7K99_RS17070	COG2823	Periplasmic or secreted lipoprotein
A7K99_RS17085	COG3107	peptidoglycan biosynthetic process
A7K99_RS17090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A7K99_RS17100	COG0583	DNA-binding transcription factor activity
A7K99_RS17105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_RS17110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS17135	COG0235	Class ii aldolase
A7K99_RS17140	COG3783	Cytochrome b(562)
A7K99_RS17145	COG0312	modulator of DNA gyrase
A7K99_RS17155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7K99_RS17160	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A7K99_RS17170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A7K99_RS17175	COG2105	PFAM AIG2 family protein
A7K99_RS17180	COG2911	Protein conserved in bacteria
A7K99_RS17185	COG0729	surface antigen
A7K99_RS17190	COG1253	flavin adenine dinucleotide binding
A7K99_RS17200	COG1218	3'(2'),5'-bisphosphate nucleotidase
A7K99_RS17205	COG0545	Peptidyl-prolyl cis-trans isomerase
A7K99_RS17210	COG3061	Opacity-associated protein A
A7K99_RS17220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7K99_RS17230	COG0360	Binds together with S18 to 16S ribosomal RNA
A7K99_RS17245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7K99_RS17250	COG0557	exoribonuclease II activity
A7K99_RS17260	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A7K99_RS17265	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A7K99_RS17270	COG0330	HflC and HflK could
A7K99_RS17275	COG0330	HflC and HflK could
A7K99_RS17280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A7K99_RS17290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7K99_RS17295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A7K99_RS17305	COG0802	atpase or kinase
A7K99_RS17310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A7K99_RS17310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A7K99_RS17325	COG0583	DNA-binding transcription factor activity
A7K99_RS17360	COG0688	phosphatidylethanolamine metabolic process
A7K99_RS17365	COG1511	domain protein
A7K99_RS17365	COG3264	Mechanosensitive ion channel
A7K99_RS17370	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A7K99_RS17375	COG5510	response to toxic substance
A7K99_RS17390	COG1509	lysine 2,3-aminomutase activity
A7K99_RS17410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A7K99_RS17415	COG3030	protein affecting phage T7 exclusion by the F plasmid
A7K99_RS17420	COG1027	Aspartate ammonia-lyase
A7K99_RS17435	COG1309	transcriptional regulator
A7K99_RS17440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7K99_RS17445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A7K99_RS17455	COG1175	transmembrane transport
A7K99_RS17460	COG1840	ABC-type Fe3 transport system, periplasmic component
A7K99_RS17465	COG1609	Transcriptional regulator
A7K99_RS17490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS17505	COG1902	pentaerythritol trinitrate reductase activity
A7K99_RS17510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS17520	COG0583	DNA-binding transcription factor activity
A7K99_RS17525	COG1902	pentaerythritol trinitrate reductase activity
A7K99_RS17530	COG2814	Major facilitator Superfamily
A7K99_RS17555	COG0583	DNA-binding transcription factor activity
A7K99_RS17575	COG0583	DNA-binding transcription factor activity
A7K99_RS17580	COG0477	Major facilitator Superfamily
A7K99_RS17605	COG2011	ABC-type metal ion transport system permease component
A7K99_RS17610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7K99_RS17615	COG1464	Belongs to the NlpA lipoprotein family
A7K99_RS17630	COG2011	ABC-type metal ion transport system permease component
A7K99_RS17635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7K99_RS17640	COG1464	Belongs to the NlpA lipoprotein family
A7K99_RS17645	COG0436	Aminotransferase
A7K99_RS17655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS17660	COG0765	amino acid transport
A7K99_RS17665	COG0765	amino acid transport
A7K99_RS17670	COG1126	abc transporter atp-binding protein
A7K99_RS17675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS17680	COG3711	transcriptional antiterminator
A7K99_RS17685	COG2723	6-phospho-beta-galactosidase activity
A7K99_RS17690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7K99_RS17690	COG2190	(PTS) system
A7K99_RS17690	COG1263	PTS System
A7K99_RS17705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS17710	COG0765	amino acid transport
A7K99_RS17715	COG0765	amino acid transport
A7K99_RS17725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_RS17745	COG2233	PERMEase
A7K99_RS17765	COG2372	response to copper ion
A7K99_RS17775	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_RS17780	COG1129	ABC transporter
A7K99_RS17785	COG1879	ABC-type sugar transport system periplasmic component
A7K99_RS17790	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_RS17795	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_RS17800	COG1129	ABC transporter
A7K99_RS17805	COG1879	ABC-type sugar transport system periplasmic component
A7K99_RS17835	COG3121	Chaperone
A7K99_RS17850	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A7K99_RS17870	COG0583	DNA-binding transcription factor activity
A7K99_RS17885	COG2271	Major facilitator Superfamily
A7K99_RS17905	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A7K99_RS17925	COG1301	dicarboxylic acid transport
A7K99_RS17930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7K99_RS17935	COG3162	membrane
A7K99_RS17940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7K99_RS17955	COG1380	Effector of murein hydrolase LrgA
A7K99_RS17960	COG0583	DNA-binding transcription factor activity
A7K99_RS17965	COG0025	NhaP-type Na H and K H
A7K99_RS17970	COG0789	Transcriptional regulator
A7K99_RS17975	COG2207	Transcriptional regulator
A7K99_RS17995	COG4993	Dehydrogenase
A7K99_RS18000	COG3961	Belongs to the TPP enzyme family
A7K99_RS18005	COG0583	DNA-binding transcription factor activity
A7K99_RS18025	COG4191	Histidine kinase
A7K99_RS18035	COG2807	transmembrane transport
A7K99_RS18055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7K99_RS18080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_RS18085	COG5000	phosphorelay sensor kinase activity
A7K99_RS18085	COG5002	protein histidine kinase activity
A7K99_RS18090	COG0745	RESPONSE REGULATOR receiver
A7K99_RS18145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_RS18155	COG0745	RESPONSE REGULATOR receiver
A7K99_RS18160	COG0642	Histidine kinase
A7K99_RS18195	COG0629	single-stranded DNA binding
A7K99_RS18205	COG1064	alcohol dehydrogenase
A7K99_RS18215	COG0667	Aldo Keto reductase
A7K99_RS18220	COG0583	DNA-binding transcription factor activity
A7K99_RS18225	COG1942	4-Oxalocrotonate Tautomerase
A7K99_RS18230	COG1609	Transcriptional regulator
A7K99_RS18235	COG1448	Aminotransferase
A7K99_RS18245	COG1522	sequence-specific DNA binding
A7K99_RS18265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7K99_RS18275	COG1442	glycosyl transferase family 8
A7K99_RS18275	COG1216	Glycosyl transferase, family 2
A7K99_RS18280	COG0735	belongs to the Fur family
A7K99_RS18285	COG0534	Mate efflux family protein
A7K99_RS18290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7K99_RS18295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A7K99_RS18305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A7K99_RS18330	COG0527	aspartate kinase activity
A7K99_RS18340	COG1283	sodium-dependent phosphate transmembrane transporter activity
A7K99_RS18345	COG3842	ATPase activity
A7K99_RS18375	COG0667	Aldo Keto reductase
A7K99_RS18380	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A7K99_RS18385	COG0583	DNA-binding transcription factor activity
A7K99_RS18390	COG1473	amidohydrolase
A7K99_RS18400	COG3385	transposase activity
A7K99_RS18455	COG3385	transposase activity
A7K99_RS18475	COG1515	deoxyribonuclease V activity
A7K99_RS18485	COG2816	NAD+ diphosphatase activity
A7K99_RS18500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7K99_RS18505	COG2104	thiamine diphosphate biosynthetic process
A7K99_RS18510	COG2022	thiamine diphosphate biosynthetic process
A7K99_RS18520	COG5342	invasion associated locus B
A7K99_RS18530	COG0085	RNA polymerase activity
A7K99_RS18540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7K99_RS18545	COG0081	regulation of translation
A7K99_RS18550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A7K99_RS18555	COG0250	Participates in transcription elongation, termination and antitermination
A7K99_RS18595	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A7K99_RS18595	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A7K99_RS18600	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A7K99_RS18635	COG1739	Uncharacterized protein family UPF0029
A7K99_RS18650	COG0183	Belongs to the thiolase family
A7K99_RS18670	COG0084	hydrolase, TatD family'
A7K99_RS18675	COG0805	protein transport
A7K99_RS18690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A7K99_RS18695	COG3165	ubiquinone biosynthetic process from chorismate
A7K99_RS18700	COG2226	methyltransferase
A7K99_RS18705	COG1322	Protein conserved in bacteria
A7K99_RS18710	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A7K99_RS18715	COG0412	Dienelactone hydrolase
A7K99_RS18725	COG1187	pseudouridine synthase activity
A7K99_RS18730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7K99_RS18735	COG0583	DNA-binding transcription factor activity
A7K99_RS18740	COG2271	Major facilitator Superfamily
A7K99_RS18745	COG0561	phosphatase activity
A7K99_RS18750	COG2267	carboxylic ester hydrolase activity
A7K99_RS18755	COG1280	lysine exporter protein (LysE YggA)
A7K99_RS18760	COG1280	lysine exporter protein (LysE YggA)
A7K99_RS18775	COG2050	protein possibly involved in aromatic compounds catabolism
A7K99_RS18785	COG2271	Major facilitator Superfamily
A7K99_RS18790	COG0583	DNA-binding transcription factor activity
A7K99_RS18795	COG0154	amidase activity
A7K99_RS18805	COG0583	DNA-binding transcription factor activity
A7K99_RS18815	COG0598	Magnesium transport protein CorA
A7K99_RS18820	COG0210	DNA helicase
A7K99_RS18825	COG1011	Hydrolase
A7K99_RS18840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7K99_RS18860	COG0181	hydroxymethylbilane synthase activity
A7K99_RS18865	COG1587	Uroporphyrinogen-III synthase
A7K99_RS18870	COG2959	enzyme of heme biosynthesis
A7K99_RS18875	COG3071	HemY protein
A7K99_RS18880	COG0431	NADPH-dependent FMN reductase
A7K99_RS18890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7K99_RS18925	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A7K99_RS18935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7K99_RS18940	COG2244	polysaccharide biosynthetic process
A7K99_RS18945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7K99_RS18950	COG0456	acetyltransferase
A7K99_RS18955	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A7K99_RS18960	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A7K99_RS18970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7K99_RS18975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A7K99_RS18980	COG3118	belongs to the thioredoxin family
A7K99_RS18985	COG0513	Belongs to the DEAD box helicase family
A7K99_RS18990	COG0248	Ppx GppA phosphatase
A7K99_RS19000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7K99_RS19010	COG1309	transcriptional regulator
A7K99_RS19020	COG2200	EAL domain
A7K99_RS19020	COG2199	diguanylate cyclase activity
A7K99_RS19025	COG4608	Belongs to the ABC transporter superfamily
A7K99_RS19030	COG0444	Belongs to the ABC transporter superfamily
A7K99_RS19035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7K99_RS19040	COG0601	transmembrane transport
A7K99_RS19045	COG0747	negative chemotaxis
A7K99_RS19085	COG2990	Protein conserved in bacteria
A7K99_RS19095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7K99_RS19100	COG1349	DNA-binding transcription factor activity
A7K99_RS19110	COG0751	glycine-tRNA ligase activity
A7K99_RS19115	COG0752	glycyl-tRNA synthetase alpha subunit
A7K99_RS19135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_RS19140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_RS19160	COG2207	Transcriptional regulator
A7K99_RS19175	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS19185	COG4807	Protein conserved in bacteria
A7K99_RS19195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_RS19200	COG0710	3-dehydroquinate dehydratase activity
A7K99_RS19210	COG3420	alginic acid biosynthetic process
A7K99_RS19215	COG1811	Na channel or pump
A7K99_RS19225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A7K99_RS19230	COG0583	DNA-binding transcription factor activity
A7K99_RS19235	COG0833	amino acid
A7K99_RS19240	COG2040	homocysteine
A7K99_RS19255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_RS19295	COG3193	protein, possibly involved in utilization of glycolate and propanediol
A7K99_RS19310	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A7K99_RS19320	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_RS19325	COG1129	ABC transporter
A7K99_RS19330	COG1879	ABC-type sugar transport system periplasmic component
A7K99_RS19335	COG1070	Carbohydrate kinase
A7K99_RS19340	COG0246	Mannitol dehydrogenase
A7K99_RS19350	COG4336	lyase activity
A7K99_RS19360	COG1984	allophanate hydrolase subunit 2
A7K99_RS19365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A7K99_RS19375	COG0583	DNA-binding transcription factor activity
A7K99_RS19380	COG0583	DNA-binding transcription factor activity
A7K99_RS19385	COG3366	ferrous iron transmembrane transporter activity
A7K99_RS19390	COG0700	Nucleoside recognition
A7K99_RS19395	COG1473	amidohydrolase
A7K99_RS19420	COG0531	amino acid
A7K99_RS19430	COG0531	amino acid
A7K99_RS19435	COG0124	histidyl-tRNA synthetase
A7K99_RS19455	COG0583	DNA-binding transcription factor activity
A7K99_RS19460	COG0477	Major facilitator Superfamily
A7K99_RS19465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_RS19470	COG2364	Membrane
A7K99_RS19485	COG2207	Transcriptional regulator
A7K99_RS19485	COG3708	Transcriptional regulator
A7K99_RS19495	COG1881	PFAM PEBP family protein
A7K99_RS19500	COG2207	Transcriptional regulator
A7K99_RS19510	COG0583	DNA-binding transcription factor activity
A7K99_RS19515	COG1271	oxidase subunit
A7K99_RS19520	COG1294	oxidase, subunit
A7K99_RS19540	COG2081	HI0933 family
A7K99_RS19545	COG0306	phosphate transporter
A7K99_RS19550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7K99_RS19555	COG1126	abc transporter atp-binding protein
A7K99_RS19560	COG0765	amino acid transport
A7K99_RS19565	COG0765	amino acid transport
A7K99_RS19585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_RS19595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7K99_RS19605	COG1802	Transcriptional regulator
A7K99_RS19615	COG0589	response to stress
A7K99_RS19620	COG0742	ribosomal rna small subunit methyltransferase
A7K99_RS19630	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A7K99_RS19640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7K99_RS19660	COG2851	Citrate transporter
A7K99_RS19680	COG2985	domain, Protein
A7K99_RS19685	COG4191	Histidine kinase
A7K99_RS19695	COG4774	siderophore transport
A7K99_RS19705	COG2814	Major facilitator Superfamily
A7K99_RS19710	COG0583	DNA-binding transcription factor activity
A7K99_RS19720	COG2862	Uncharacterized protein family, UPF0114
A7K99_RS19740	COG1132	(ABC) transporter
A7K99_RS19755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7K99_RS19760	COG0601	transmembrane transport
A7K99_RS19765	COG0747	negative chemotaxis
A7K99_RS19775	COG4172	Belongs to the ABC transporter superfamily
A7K99_RS19785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A7K99_RS19790	COG1971	Probably functions as a manganese efflux pump
A7K99_RS19805	COG0625	glutathione transferase activity
A7K99_RS19810	COG1295	ribonuclease BN
A7K99_RS19820	COG0477	Major facilitator Superfamily
A7K99_RS19830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A7K99_RS19835	COG0583	DNA-binding transcription factor activity
A7K99_RS19845	COG0129	dihydroxy-acid dehydratase activity
A7K99_RS19850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7K99_RS19855	COG3978	acetolactate synthase activity
A7K99_RS19870	COG3085	chromosome segregation
A7K99_RS19875	COG0583	DNA-binding transcription factor activity
A7K99_RS19915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7K99_RS19925	COG1309	transcriptional regulator
A7K99_RS19930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7K99_RS19940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A7K99_RS19940	COG0678	peroxiredoxin activity
A7K99_RS19950	COG0137	argininosuccinate synthase activity
A7K99_RS19965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_RS19970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A7K99_RS19980	COG0527	aspartate kinase activity
A7K99_RS19980	COG0460	homoserine dehydrogenase
A7K99_RS19985	COG0626	cystathionine gamma-synthase activity
A7K99_RS19995	COG0254	rRNA binding
A7K99_RS20000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7K99_RS20005	COG1609	Transcriptional regulator
A7K99_RS20010	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7K99_RS20015	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A7K99_RS20025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7K99_RS20030	COG3074	FtsZ-dependent cytokinesis
A7K99_RS20035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7K99_RS20045	COG1494	fructose-1,6-bisphosphatase
A7K99_RS20050	COG2814	Major facilitator Superfamily
A7K99_RS20065	COG0149	triose-phosphate isomerase activity
A7K99_RS20070	COG2134	cdp-diacylglycerol pyrophosphatase
A7K99_RS20075	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A7K99_RS20080	COG0205	6-phosphofructokinase activity
A7K99_RS20090	COG3539	Fimbrial protein
A7K99_RS20110	COG3539	Fimbrial protein
A7K99_RS20115	COG3710	Transcriptional regulator
A7K99_RS20125	COG3678	ATP-independent chaperone mediated protein folding
A7K99_RS20130	COG0745	RESPONSE REGULATOR receiver
A7K99_RS20135	COG2205	protein histidine kinase activity
A7K99_RS20140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A7K99_RS20150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7K99_RS20155	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A7K99_RS20160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A7K99_RS20165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7K99_RS20170	COG4942	peptidase
A7K99_RS20175	COG2861	carbohydrate metabolic process
A7K99_RS20180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7K99_RS20185	COG0859	PFAM glycosyl transferase family 9
A7K99_RS20190	COG0859	PFAM glycosyl transferase family 9
A7K99_RS20200	COG3307	-O-antigen
A7K99_RS20210	COG0438	transferase activity, transferring glycosyl groups
A7K99_RS20215	COG0859	PFAM glycosyl transferase family 9
A7K99_RS20220	COG0859	PFAM glycosyl transferase family 9
A7K99_RS20225	COG0438	transferase activity, transferring glycosyl groups
A7K99_RS20230	COG1519	Transferase
A7K99_RS20245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7K99_RS20255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7K99_RS20260	COG2003	Belongs to the UPF0758 family
A7K99_RS20265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A7K99_RS20275	COG1309	transcriptional regulator
A7K99_RS20285	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A7K99_RS20290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A7K99_RS20300	COG1561	YicC-like family, N-terminal region
A7K99_RS20305	COG1846	Transcriptional regulator
A7K99_RS20315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7K99_RS20315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7K99_RS20325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7K99_RS20330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A7K99_RS20335	COG3084	Protein conserved in bacteria
A7K99_RS20340	COG3385	transposase activity
A7K99_RS20345	COG0746	molybdenum cofactor guanylyltransferase activity
A7K99_RS20350	COG1763	Mo-molybdopterin cofactor biosynthetic process
A7K99_RS20380	COG0477	Major facilitator Superfamily
A7K99_RS20385	COG1609	Transcriptional regulator
A7K99_RS20390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_RS20395	COG1879	ABC-type sugar transport system periplasmic component
A7K99_RS20400	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_RS20405	COG1129	ABC transporter
A7K99_RS20425	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A7K99_RS20430	COG1522	sequence-specific DNA binding
A7K99_RS20435	COG0716	FMN binding
A7K99_RS20450	COG3312	ion transport
A7K99_RS20455	COG0356	it plays a direct role in the translocation of protons across the membrane
A7K99_RS20470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7K99_RS20475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A7K99_RS20480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A7K99_RS20485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A7K99_RS20500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7K99_RS20510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS20525	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A7K99_RS20530	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_RS20565	COG0583	DNA-binding transcription factor activity
A7K99_RS20570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7K99_RS20610	COG1116	anion transmembrane transporter activity
A7K99_RS20610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_RS20630	COG1116	anion transmembrane transporter activity
A7K99_RS20635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_RS20645	COG0154	amidase activity
A7K99_RS20650	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A7K99_RS20655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7K99_RS20660	COG3539	Fimbrial protein
A7K99_RS20665	COG3539	Fimbrial protein
A7K99_RS20670	COG3121	Chaperone
A7K99_RS20675	COG3188	usher protein
A7K99_RS20680	COG3539	Fimbrial protein
A7K99_RS20685	COG3539	Fimbrial protein
A7K99_RS20690	COG3539	Fimbrial protein
A7K99_RS20695	COG3539	Fimbrial protein
A7K99_RS20720	COG3707	response regulator
A7K99_RS20730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_RS20740	COG1116	anion transmembrane transporter activity
A7K99_RS20745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7K99_RS20745	COG2146	nitrite reductase [NAD(P)H] activity
A7K99_RS20750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7K99_RS20750	COG1648	precorrin-2 dehydrogenase activity
A7K99_RS20755	COG0243	molybdopterin cofactor binding
A7K99_RS20760	COG2207	Transcriptional regulator
A7K99_RS20790	COG2175	clavaminate synthase activity
A7K99_RS20800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_RS20805	COG1464	Belongs to the NlpA lipoprotein family
A7K99_RS20820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_RS20840	COG0765	amino acid transport
A7K99_RS20845	COG1126	abc transporter atp-binding protein
A7K99_RS20860	COG4772	TonB-dependent receptor
A7K99_RS20865	COG3712	iron ion homeostasis
A7K99_RS20870	COG1595	DNA-templated transcription, initiation
A7K99_RS20890	COG2706	6-phosphogluconolactonase activity
A7K99_RS20895	COG2271	Major facilitator Superfamily
A7K99_RS20900	COG1609	Transcriptional regulator
A7K99_RS20915	COG3395	kinase activity
A7K99_RS20920	COG2707	UPF0756 membrane protein
A7K99_RS20950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A7K99_RS20960	COG3078	GTPase activator activity
A7K99_RS20975	COG3852	Histidine kinase
A7K99_RS21000	COG0477	Major facilitator Superfamily
A7K99_RS21010	COG2207	Transcriptional regulator
A7K99_RS21030	COG1011	Hydrolase
A7K99_RS21045	COG0456	acetyltransferase
A7K99_RS21050	COG2982	Protein involved in outer membrane biogenesis
A7K99_RS21055	COG2233	PERMEase
A7K99_RS21060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A7K99_RS21065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7K99_RS21070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7K99_RS21075	COG1758	RNA polymerase activity
A7K99_RS21080	COG0194	GDP metabolic process
A7K99_RS21090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A7K99_RS21095	COG0573	inorganic phosphate transmembrane transporter activity
A7K99_RS21100	COG0581	inorganic phosphate transmembrane transporter activity
A7K99_RS21110	COG0704	Plays a role in the regulation of phosphate uptake
A7K99_RS21115	COG2814	Major facilitator Superfamily
A7K99_RS21145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A7K99_RS21150	COG0706	membrane insertase activity
A7K99_RS21160	COG0594	ribonuclease P activity