locus-tag	class	description
TASI_RS00020	COG0564	pseudouridine synthase activity
TASI_RS00025	COG4608	Belongs to the ABC transporter superfamily
TASI_RS00030	COG0601	transmembrane transport
TASI_RS00035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TASI_RS00040	COG0444	Belongs to the ABC transporter superfamily
TASI_RS00045	COG4166	transmembrane transport
TASI_RS00055	COG1074	ATP-dependent DNA helicase activity
TASI_RS00070	COG0551	DNA topoisomerase type I activity
TASI_RS00070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TASI_RS00075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TASI_RS00090	COG2922	Belongs to the Smg family
TASI_RS00110	COG0018	arginyl-trna synthetase
TASI_RS00120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TASI_RS00150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TASI_RS00170	COG1160	GTP binding
TASI_RS00195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TASI_RS00205	COG4160	amino acid transport
TASI_RS00210	COG4598	ABC transporter
TASI_RS00215	COG0730	response to heat
TASI_RS00230	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TASI_RS00240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TASI_RS00250	COG1994	Peptidase M50
TASI_RS00255	COG0859	PFAM glycosyl transferase family 9
TASI_RS00270	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TASI_RS00285	COG1686	Belongs to the peptidase S11 family
TASI_RS00315	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TASI_RS00320	COG1088	dTDP-glucose 4,6-dehydratase activity
TASI_RS00350	COG0513	Belongs to the DEAD box helicase family
TASI_RS00355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TASI_RS00360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TASI_RS00360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TASI_RS00370	COG5000	phosphorelay sensor kinase activity
TASI_RS00375	COG2204	response regulator
TASI_RS00380	COG0569	domain protein
TASI_RS00390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TASI_RS00395	COG1040	competence protein
TASI_RS00400	COG2226	methyltransferase
TASI_RS00685	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TASI_RS00690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TASI_RS00695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TASI_RS00700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TASI_RS00705	COG0588	phosphoglycerate mutase activity
TASI_RS00710	COG4942	peptidase
TASI_RS00715	COG0793	Belongs to the peptidase S41A family
TASI_RS00725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TASI_RS00740	COG0356	it plays a direct role in the translocation of protons across the membrane
TASI_RS00755	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TASI_RS00760	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TASI_RS00765	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TASI_RS00770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TASI_RS00775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TASI_RS00780	COG2944	sequence-specific DNA binding
TASI_RS00790	COG4771	TonB-dependent receptor
TASI_RS00795	COG1131	(ABC) transporter
TASI_RS00825	COG0523	cobalamin synthesis protein
TASI_RS00830	COG0735	belongs to the Fur family
TASI_RS00835	COG1121	(ABC) transporter
TASI_RS00840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TASI_RS00845	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TASI_RS00855	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TASI_RS00860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TASI_RS00865	COG0154	amidase activity
TASI_RS00870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TASI_RS00875	COG1077	Cell shape determining protein MreB Mrl
TASI_RS00890	COG0768	penicillin binding
TASI_RS00895	COG0772	Belongs to the SEDS family
TASI_RS00905	COG2884	Cell division ATP-binding protein ftsE
TASI_RS00910	COG4597	amino acid ABC transporter
TASI_RS00915	COG0765	amino acid transport
TASI_RS00920	COG1126	abc transporter atp-binding protein
TASI_RS00930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TASI_RS00955	COG0237	dephospho-CoA kinase activity
TASI_RS00960	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TASI_RS00965	COG1045	serine acetyltransferase
TASI_RS00970	COG0494	nUDIX hydrolase
TASI_RS00980	COG0142	geranyltranstransferase activity
TASI_RS00985	COG0129	dihydroxy-acid dehydratase activity
TASI_RS00990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TASI_RS01010	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TASI_RS01025	COG3284	Transcriptional regulator
TASI_RS01030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TASI_RS01035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TASI_RS01045	COG1373	ATPase (AAA superfamily
TASI_RS01050	COG0826	peptidase U32
TASI_RS01075	COG0601	transmembrane transport
TASI_RS01080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TASI_RS01090	COG4608	Belongs to the ABC transporter superfamily
TASI_RS01100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TASI_RS01110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TASI_RS01115	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
TASI_RS01120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TASI_RS01125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TASI_RS01130	COG2823	Periplasmic or secreted lipoprotein
TASI_RS01135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TASI_RS01140	COG0792	nuclease activity
TASI_RS01155	COG1660	Displays ATPase and GTPase activities
TASI_RS01160	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TASI_RS01165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TASI_RS01170	COG1137	ATPase activity
TASI_RS01195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TASI_RS01200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TASI_RS01210	COG0745	RESPONSE REGULATOR receiver
TASI_RS01215	COG2226	methyltransferase
TASI_RS01225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TASI_RS01230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TASI_RS01245	COG2326	polyphosphate kinase activity
TASI_RS01265	COG0720	synthase
TASI_RS01270	COG0602	queuosine metabolic process
TASI_RS01295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TASI_RS01305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TASI_RS01320	COG0471	metal ion transport
TASI_RS01325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TASI_RS01370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TASI_RS01370	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TASI_RS01380	COG2830	Protein of unknown function (DUF452)
TASI_RS01385	COG0500	methyltransferase
TASI_RS01395	COG0584	glycerophosphoryl diester phosphodiesterase
TASI_RS01400	COG1063	alcohol dehydrogenase
TASI_RS01415	COG2119	membrane
TASI_RS01420	COG4783	chaperone-mediated protein folding
TASI_RS01425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TASI_RS01425	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TASI_RS01430	COG0037	tRNA processing
TASI_RS01440	COG0492	ferredoxin-NADP+ reductase activity
TASI_RS01445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TASI_RS01455	COG4215	(ABC) transporter
TASI_RS01470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TASI_RS01475	COG0589	response to stress
TASI_RS01480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TASI_RS01520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TASI_RS01525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TASI_RS01530	COG1652	LysM domain
TASI_RS01535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TASI_RS01550	COG0489	protein tyrosine kinase activity
TASI_RS01565	COG0717	Belongs to the dCTP deaminase family
TASI_RS01570	COG2081	HI0933 family
TASI_RS01580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TASI_RS01585	COG0509	glycine decarboxylation via glycine cleavage system
TASI_RS01590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TASI_RS01590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TASI_RS01595	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TASI_RS01605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TASI_RS01615	COG0277	FAD linked oxidase domain protein
TASI_RS01620	COG0457	Tetratricopeptide repeat
TASI_RS01625	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TASI_RS01630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TASI_RS01640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TASI_RS01645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TASI_RS01660	COG0012	GTP binding
TASI_RS01665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TASI_RS01675	COG0742	ribosomal rna small subunit methyltransferase
TASI_RS01700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TASI_RS01705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TASI_RS01710	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TASI_RS01715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TASI_RS01720	COG1546	Belongs to the CinA family
TASI_RS01725	COG0284	orotidine-5'-phosphate decarboxylase activity
TASI_RS01730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TASI_RS01740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TASI_RS01745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TASI_RS01775	COG0823	Involved in the tonB-independent uptake of proteins
TASI_RS01785	COG0848	biopolymer transport protein
TASI_RS01790	COG0811	peptide transport
TASI_RS01795	COG0824	Thioesterase
TASI_RS01800	COG0442	prolyl-tRNA aminoacylation
TASI_RS01805	COG0494	nUDIX hydrolase
TASI_RS01835	COG0506	proline dehydrogenase activity
TASI_RS01835	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
TASI_RS01835	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
TASI_RS01840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TASI_RS01875	COG0733	neurotransmitter:sodium symporter activity
TASI_RS01880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TASI_RS01890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TASI_RS01905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TASI_RS01940	COG0418	dihydroorotase activity
TASI_RS01945	COG4122	O-methyltransferase activity
TASI_RS01955	COG0747	negative chemotaxis
TASI_RS01960	COG0747	negative chemotaxis
TASI_RS01965	COG0601	transmembrane transport
TASI_RS01970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TASI_RS01975	COG0444	Belongs to the ABC transporter superfamily
TASI_RS01980	COG4608	Belongs to the ABC transporter superfamily
TASI_RS01985	COG0604	alcohol dehydrogenase
TASI_RS01985	COG1028	Short-chain dehydrogenase reductase Sdr
TASI_RS01985	COG3321	synthase
TASI_RS01995	COG0149	triose-phosphate isomerase activity
TASI_RS02000	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TASI_RS02035	COG0629	single-stranded DNA binding
TASI_RS02150	COG3728	DNA packaging
TASI_RS02270	COG3772	lysozyme
TASI_RS02290	COG4197	protein conserved in bacteria, prophage-related
TASI_RS02330	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
TASI_RS02335	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TASI_RS02340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TASI_RS02345	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TASI_RS02350	COG0649	NAD binding
TASI_RS02355	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TASI_RS02370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TASI_RS02375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TASI_RS02385	COG0713	ATP synthesis coupled electron transport
TASI_RS02400	COG1007	ATP synthesis coupled electron transport
TASI_RS02420	COG0560	Phosphoserine phosphatase
TASI_RS02425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TASI_RS02430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TASI_RS02435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TASI_RS02445	COG0450	alkyl hydroperoxide reductase
TASI_RS02460	COG1214	PFAM Peptidase M22, glycoprotease
TASI_RS02485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TASI_RS02490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TASI_RS02500	COG2917	probably involved in intracellular septation
TASI_RS02540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TASI_RS02550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TASI_RS02560	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TASI_RS02565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TASI_RS02570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TASI_RS02575	COG1530	ribonuclease E activity
TASI_RS02580	COG0564	pseudouridine synthase activity
TASI_RS02595	COG0424	maF-like protein
TASI_RS02605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TASI_RS02610	COG0416	fatty acid biosynthetic process
TASI_RS02615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TASI_RS02620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TASI_RS02625	COG1028	Short-chain dehydrogenase reductase Sdr
TASI_RS02630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TASI_RS02635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TASI_RS02645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TASI_RS02655	COG0681	Belongs to the peptidase S26 family
TASI_RS02660	COG0571	ribonuclease III activity
TASI_RS02665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TASI_RS02670	COG1381	Involved in DNA repair and RecF pathway recombination
TASI_RS02685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TASI_RS02695	COG0583	DNA-binding transcription factor activity
TASI_RS02700	COG3226	Transcriptional regulator
TASI_RS02715	COG0791	NLP P60 protein
TASI_RS02725	COG0006	proline dipeptidase activity
TASI_RS02735	COG1842	Phage shock protein A
TASI_RS02745	COG0484	heat shock protein binding
TASI_RS02760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TASI_RS02765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TASI_RS02770	COG0534	Mate efflux family protein
TASI_RS02780	COG0254	rRNA binding
TASI_RS02785	COG2003	Belongs to the UPF0758 family
TASI_RS02790	COG1047	Peptidyl-prolyl cis-trans
TASI_RS02795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TASI_RS02805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TASI_RS02810	COG0799	negative regulation of ribosome biogenesis
TASI_RS02815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TASI_RS02825	COG0217	transcriptional regulatory protein
TASI_RS02830	COG0433	COG0433 Predicted ATPase
TASI_RS02840	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TASI_RS02845	COG0308	aminopeptidase N
TASI_RS02850	COG0312	modulator of DNA gyrase
TASI_RS02855	COG0482	sulfurtransferase activity
TASI_RS02865	COG3909	cytochrome
TASI_RS02885	COG0069	glutamate synthase activity
TASI_RS02915	COG0488	(ABC) transporter
TASI_RS02920	COG2951	lytic endotransglycosylase activity
TASI_RS02925	COG0793	Belongs to the peptidase S41A family
TASI_RS02940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TASI_RS02960	COG0077	Prephenate dehydratase
TASI_RS02960	COG1605	Chorismate mutase
TASI_RS02965	COG0287	Prephenate dehydrogenase
TASI_RS02970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TASI_RS02980	COG0776	regulation of translation
TASI_RS02990	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TASI_RS02995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TASI_RS03000	COG1596	polysaccharide export
TASI_RS03000	COG1555	photosystem II stabilization
TASI_RS03015	COG3278	Belongs to the heme-copper respiratory oxidase family
TASI_RS03045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TASI_RS03055	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TASI_RS03065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TASI_RS03080	COG1981	membrane
TASI_RS03095	COG0495	leucyl-tRNA aminoacylation
TASI_RS03100	COG2195	Cleaves the N-terminal amino acid of tripeptides
TASI_RS03105	COG2850	peptidyl-arginine hydroxylation
TASI_RS03110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TASI_RS03115	COG0668	transmembrane transport
TASI_RS03125	COG0483	inositol monophosphate 1-phosphatase activity
TASI_RS03130	COG1968	undecaprenyl-diphosphatase activity
TASI_RS03135	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TASI_RS03150	COG0215	cysteine-tRNA ligase activity
TASI_RS03155	COG0825	malonyl-CoA metabolic process
TASI_RS03160	COG0037	tRNA processing
TASI_RS03175	COG2358	TRAP transporter, solute receptor (TAXI family
TASI_RS03195	COG0527	aspartate kinase activity
TASI_RS03205	COG1666	GTP binding
TASI_RS03210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TASI_RS03220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TASI_RS03225	COG1049	propionate catabolic process, 2-methylcitrate cycle
TASI_RS03245	COG0671	phosphoesterase, PA-phosphatase related
TASI_RS03260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TASI_RS03280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TASI_RS03280	COG0543	2 iron, 2 sulfur cluster binding
TASI_RS03290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TASI_RS03295	COG0425	Belongs to the sulfur carrier protein TusA family
TASI_RS03300	COG0228	four-way junction DNA binding
TASI_RS03305	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TASI_RS03310	COG0336	Belongs to the RNA methyltransferase TrmD family
TASI_RS03315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TASI_RS03325	COG1104	cysteine desulfurase activity
TASI_RS03330	COG0822	iron-sulfur transferase activity
TASI_RS03335	COG0316	Belongs to the HesB IscA family
TASI_RS03340	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TASI_RS03345	COG0443	Heat shock 70 kDa protein
TASI_RS03350	COG0633	Ferredoxin
TASI_RS03375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TASI_RS03380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TASI_RS03400	COG1136	(ABC) transporter
TASI_RS03410	COG0084	hydrolase, TatD family'
TASI_RS03420	COG0613	PHP domain protein
TASI_RS03430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TASI_RS03435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TASI_RS03440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TASI_RS03445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TASI_RS03450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TASI_RS03460	COG0776	regulation of translation
TASI_RS03470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TASI_RS03475	COG1304	FMN binding
TASI_RS03480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TASI_RS03490	COG0210	DNA helicase
TASI_RS03505	COG1686	Belongs to the peptidase S11 family
TASI_RS03510	COG0047	phosphoribosylformylglycinamidine synthase activity
TASI_RS03510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TASI_RS03525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TASI_RS03525	COG0519	Catalyzes the synthesis of GMP from XMP
TASI_RS03540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TASI_RS03575	COG1619	proteins homologs of microcin C7 resistance protein MccF
TASI_RS03580	COG0488	(ABC) transporter
TASI_RS03590	COG2252	PERMEase
TASI_RS03600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TASI_RS03610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TASI_RS03615	COG4942	peptidase
TASI_RS03625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TASI_RS03635	COG1028	Short-chain dehydrogenase reductase Sdr
TASI_RS03640	COG0405	Gamma-glutamyltransferase
TASI_RS03650	COG0045	succinate-CoA ligase (ADP-forming) activity
TASI_RS03655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TASI_RS03660	COG0861	Integral membrane protein TerC family
TASI_RS03665	COG0181	hydroxymethylbilane synthase activity
TASI_RS03685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TASI_RS03700	COG0525	valine-tRNA ligase activity
TASI_RS03705	COG0105	UTP biosynthetic process
TASI_RS03710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TASI_RS03725	COG0124	histidyl-tRNA synthetase
TASI_RS03730	COG2976	Protein conserved in bacteria
TASI_RS03735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TASI_RS03740	COG1160	GTP binding
TASI_RS03745	COG1923	regulation of RNA biosynthetic process
TASI_RS03750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TASI_RS03755	COG0330	HflC and HflK could
TASI_RS03760	COG0330	HflC and HflK could
TASI_RS03765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TASI_RS03775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TASI_RS03800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TASI_RS03830	COG4964	Belongs to the GSP D family
TASI_RS03860	COG0335	large ribosomal subunit rRNA binding
TASI_RS03865	COG1162	GTPase activity
TASI_RS03870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TASI_RS03875	COG0736	holo-[acyl-carrier-protein] synthase activity
TASI_RS03880	COG1472	Belongs to the glycosyl hydrolase 3 family
TASI_RS03885	COG0322	excinuclease ABC activity
TASI_RS03890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TASI_RS03895	COG2086	electron transfer activity
TASI_RS03910	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TASI_RS03915	COG0038	chloride channel
TASI_RS03920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TASI_RS03925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TASI_RS03930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TASI_RS03935	COG1295	ribonuclease BN
TASI_RS03955	COG0473	3-isopropylmalate dehydrogenase activity
TASI_RS03960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TASI_RS03965	COG0101	tRNA pseudouridine synthase activity
TASI_RS03985	COG0488	(ABC) transporter
TASI_RS03990	COG2890	protein-(glutamine-N5) methyltransferase activity
TASI_RS03995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TASI_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
TASI_RS04030	COG0628	permease
TASI_RS04040	COG2358	TRAP transporter, solute receptor (TAXI family
TASI_RS04050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TASI_RS04060	COG0556	nucleotide-excision repair
TASI_RS04075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TASI_RS04080	COG2137	regulation of response to DNA damage stimulus
TASI_RS04085	COG0859	PFAM glycosyl transferase family 9
TASI_RS04090	COG0165	Argininosuccinate lyase
TASI_RS04100	COG0347	Belongs to the P(II) protein family
TASI_RS04105	COG1187	pseudouridine synthase activity
TASI_RS04115	COG0708	Exodeoxyribonuclease III
TASI_RS04125	COG3181	Tripartite tricarboxylate transporter family receptor
TASI_RS04135	COG0697	spore germination
TASI_RS04140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TASI_RS04145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TASI_RS04150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TASI_RS04175	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TASI_RS04185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TASI_RS04185	COG2111	Na H antiporter
TASI_RS04190	COG1006	Multisubunit Na H antiporter MnhC subunit
TASI_RS04195	COG0651	ATP synthesis coupled electron transport
TASI_RS04205	COG2212	antiporter activity
TASI_RS04210	COG1320	monovalent cation:proton antiporter activity
TASI_RS04220	COG0084	hydrolase, TatD family'
TASI_RS04225	COG0470	DNA polymerase III
TASI_RS04230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TASI_RS04235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TASI_RS04240	COG0354	folic acid binding
TASI_RS04250	COG2867	negative regulation of translational initiation
TASI_RS04255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TASI_RS04275	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TASI_RS04280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TASI_RS04290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TASI_RS04295	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TASI_RS04300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TASI_RS04305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TASI_RS04310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TASI_RS04330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TASI_RS04335	COG0575	Belongs to the CDS family
TASI_RS04340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TASI_RS04345	COG0233	cytoplasmic translational termination
TASI_RS04350	COG0528	UMP kinase activity
TASI_RS04355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TASI_RS04360	COG0052	Belongs to the universal ribosomal protein uS2 family
TASI_RS04365	COG0024	Methionine aminopeptidase
TASI_RS04370	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TASI_RS04405	COG0285	dihydrofolate synthase activity
TASI_RS04410	COG3038	cytochrome b561
TASI_RS04415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TASI_RS04420	COG0508	dehydrogenase complex catalyzes the overall conversion of
TASI_RS04440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TASI_RS04445	COG0339	signal peptide processing
TASI_RS04450	COG1999	signal sequence binding
TASI_RS04455	COG0410	ABC transporter
TASI_RS04475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TASI_RS04485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TASI_RS04490	COG1570	exodeoxyribonuclease VII activity
TASI_RS04495	COG1663	tetraacyldisaccharide 4'-kinase activity
TASI_RS04500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TASI_RS04505	COG0563	adenylate kinase activity
TASI_RS04510	COG0728	peptidoglycan biosynthetic process
TASI_RS04515	COG0268	Binds directly to 16S ribosomal RNA
TASI_RS04525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TASI_RS04530	COG0137	argininosuccinate synthase activity
TASI_RS04545	COG0842	Transport permease protein
TASI_RS04550	COG0842	Transport permease protein
TASI_RS04550	COG1129	ABC transporter
TASI_RS04560	COG0776	regulation of translation
TASI_RS04570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TASI_RS04575	COG0557	exoribonuclease II activity
TASI_RS04580	COG0730	response to heat
TASI_RS04600	COG2833	Protein of unknown function (DUF455)
TASI_RS04630	COG1525	nuclease
TASI_RS04665	COG0302	gtp cyclohydrolase
TASI_RS04670	COG1530	ribonuclease E activity
TASI_RS04675	COG1132	(ABC) transporter
TASI_RS04690	COG1643	Atp-dependent helicase
TASI_RS04695	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TASI_RS04700	COG0704	Plays a role in the regulation of phosphate uptake
TASI_RS04705	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TASI_RS04710	COG1177	transmembrane transport
TASI_RS04715	COG1176	ABC-type spermidine putrescine transport system, permease component I
TASI_RS04720	COG3842	ATPase activity
TASI_RS04725	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TASI_RS04735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TASI_RS04760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TASI_RS04765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TASI_RS04770	COG0194	GDP metabolic process
TASI_RS04775	COG1758	RNA polymerase activity
TASI_RS04780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TASI_RS04800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TASI_RS04805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TASI_RS04810	COG0508	dehydrogenase complex catalyzes the overall conversion of
TASI_RS04815	COG0567	Dehydrogenase, E1 component
TASI_RS04820	COG0280	phosphate acetyltransferase
TASI_RS04820	COG0281	malic enzyme
TASI_RS04830	COG0786	glutamate:sodium symporter activity
TASI_RS04845	COG3971	2-oxopent-4-enoate hydratase activity
TASI_RS04855	COG2814	Major facilitator Superfamily
TASI_RS04865	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TASI_RS04930	COG0523	cobalamin synthesis protein
TASI_RS04945	COG3842	ATPase activity
TASI_RS04955	COG0395	ABC-type sugar transport system, permease component
TASI_RS04960	COG1840	ABC-type Fe3 transport system, periplasmic component
TASI_RS04970	COG0372	Belongs to the citrate synthase family
TASI_RS04975	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TASI_RS04980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TASI_RS04985	COG1053	succinate dehydrogenase
TASI_RS05000	COG0039	L-malate dehydrogenase activity
TASI_RS05005	COG3177	Filamentation induced by cAMP protein fic
TASI_RS05010	COG1012	belongs to the aldehyde dehydrogenase family
TASI_RS05050	COG3209	COG3209 Rhs family protein
TASI_RS05060	COG3209	COG3209 Rhs family protein
TASI_RS05115	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TASI_RS05120	COG0148	phosphopyruvate hydratase activity
TASI_RS05130	COG0504	CTP synthase activity
TASI_RS05140	COG0583	DNA-binding transcription factor activity
TASI_RS05145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TASI_RS05150	COG1757	Na H antiporter
TASI_RS05155	COG1012	belongs to the aldehyde dehydrogenase family
TASI_RS05160	COG2423	ornithine cyclodeaminase activity
TASI_RS05165	COG1301	dicarboxylic acid transport
TASI_RS05170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TASI_RS05175	COG5383	Protein conserved in bacteria
TASI_RS05210	COG2841	Protein conserved in bacteria
TASI_RS05215	COG0748	coenzyme F420 binding
TASI_RS05230	COG1217	gtp-binding protein TYPA
TASI_RS05235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TASI_RS05240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TASI_RS05245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TASI_RS05250	COG0195	Participates in both transcription termination and antitermination
TASI_RS05250	COG2251	uridine kinase activity
TASI_RS05255	COG0779	Required for maturation of 30S ribosomal subunits
TASI_RS05260	COG1187	pseudouridine synthase activity
TASI_RS05265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TASI_RS05275	COG0564	pseudouridine synthase activity
TASI_RS05285	COG1199	ATP-dependent helicase activity
TASI_RS05290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TASI_RS05300	COG0210	DNA helicase
TASI_RS05305	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TASI_RS05305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TASI_RS05310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TASI_RS05315	COG0196	riboflavin kinase activity
TASI_RS05320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TASI_RS05330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TASI_RS05340	COG0756	dUTP diphosphatase activity
TASI_RS05350	COG0542	response to heat
TASI_RS05355	COG1278	Cold shock
TASI_RS05365	COG0583	DNA-binding transcription factor activity
TASI_RS05380	COG1840	ABC-type Fe3 transport system, periplasmic component
TASI_RS05385	COG1178	ABC-type Fe3 transport system permease component
TASI_RS05390	COG3842	ATPase activity
TASI_RS05405	COG0174	glutamine synthetase
TASI_RS05410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TASI_RS05415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TASI_RS05420	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TASI_RS05425	COG1561	YicC-like family, N-terminal region
TASI_RS05430	COG0305	Participates in initiation and elongation during chromosome replication
TASI_RS05440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TASI_RS05450	COG0360	Binds together with S18 to 16S ribosomal RNA
TASI_RS05455	COG1469	GTP cyclohydrolase I activity
TASI_RS05460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TASI_RS05465	COG0142	geranyltranstransferase activity
TASI_RS05470	COG1722	exodeoxyribonuclease VII activity
TASI_RS05480	COG2986	histidine ammonia-lyase
TASI_RS05485	COG2188	Transcriptional regulator
TASI_RS05500	COG0501	Belongs to the peptidase M48B family
TASI_RS05505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TASI_RS05505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TASI_RS05510	COG1611	Belongs to the LOG family
TASI_RS05515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TASI_RS05525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TASI_RS05530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TASI_RS05540	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TASI_RS05545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TASI_RS05555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TASI_RS05560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TASI_RS05565	COG0740	serine-type endopeptidase activity
TASI_RS05570	COG0544	peptidyl-prolyl cis-trans isomerase activity
TASI_RS05580	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TASI_RS05585	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TASI_RS05615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TASI_RS05620	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TASI_RS05660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TASI_RS05680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TASI_RS05695	COG1185	polyribonucleotide nucleotidyltransferase activity
TASI_RS05700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TASI_RS05710	COG1115	amino acid carrier protein
TASI_RS05715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TASI_RS05720	COG0440	acetolactate synthase activity
TASI_RS05725	COG0028	Belongs to the TPP enzyme family
TASI_RS05730	COG3022	response to hydroperoxide
TASI_RS05735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TASI_RS05740	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TASI_RS05745	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TASI_RS05750	COG1674	ftsk spoiiie
TASI_RS05755	COG0492	ferredoxin-NADP+ reductase activity
TASI_RS05775	COG2855	membrane
TASI_RS05795	COG0443	Heat shock 70 kDa protein
TASI_RS05800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TASI_RS05810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TASI_RS05815	COG1420	regulation of RNA biosynthetic process
TASI_RS05820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TASI_RS05825	COG0497	DNA recombination
TASI_RS05835	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TASI_RS05840	COG0735	belongs to the Fur family
TASI_RS05860	COG1230	cation diffusion facilitator family transporter
TASI_RS05880	COG2837	iron assimilation
TASI_RS05890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TASI_RS05910	COG0248	Ppx GppA phosphatase
TASI_RS05920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TASI_RS05930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TASI_RS05935	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TASI_RS05940	COG1534	Rna-binding protein
TASI_RS05945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TASI_RS05950	COG2233	PERMEase
TASI_RS05960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TASI_RS05965	COG0505	Belongs to the CarA family
TASI_RS05970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TASI_RS05985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TASI_RS05990	COG1074	ATP-dependent DNA helicase activity
TASI_RS06010	COG3384	dioxygenase
TASI_RS06020	COG4974	Belongs to the 'phage' integrase family
TASI_RS06025	COG0802	atpase or kinase
TASI_RS06030	COG0860	N-Acetylmuramoyl-L-alanine amidase
TASI_RS06035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TASI_RS06045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TASI_RS06050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TASI_RS06055	COG0617	tRNA 3'-terminal CCA addition
TASI_RS06060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TASI_RS06070	COG0166	Belongs to the GPI family
TASI_RS06075	COG3258	Cytochrome c
TASI_RS06105	COG0167	dihydroorotate dehydrogenase activity
TASI_RS06115	COG0513	Belongs to the DEAD box helicase family
TASI_RS06135	COG0138	bifunctional purine biosynthesis protein purh
TASI_RS06140	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TASI_RS06145	COG0632	four-way junction helicase activity
TASI_RS06160	COG2255	four-way junction helicase activity
TASI_RS06180	COG2022	thiamine diphosphate biosynthetic process
TASI_RS06205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TASI_RS06205	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TASI_RS06210	COG2239	Acts as a magnesium transporter
TASI_RS06215	COG0653	protein targeting
TASI_RS06220	COG0739	heme binding
TASI_RS06230	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TASI_RS06245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TASI_RS06250	COG1181	Belongs to the D-alanine--D-alanine ligase family
TASI_RS06255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TASI_RS06260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TASI_RS06265	COG0772	Belongs to the SEDS family
TASI_RS06270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TASI_RS06275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TASI_RS06280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TASI_RS06295	COG0275	rRNA processing
TASI_RS06300	COG2001	Belongs to the MraZ family
TASI_RS06305	COG0753	catalase activity
TASI_RS06310	COG0752	glycyl-tRNA synthetase alpha subunit
TASI_RS06315	COG0751	glycine-tRNA ligase activity
TASI_RS06320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TASI_RS06335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TASI_RS06340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TASI_RS06345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TASI_RS06355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TASI_RS06375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TASI_RS06380	COG0850	regulation of cytokinetic process
TASI_RS06385	COG2894	cell division
TASI_RS06390	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TASI_RS06395	COG0402	S-adenosylhomocysteine deaminase activity
TASI_RS06405	COG0488	(ABC) transporter
TASI_RS06415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TASI_RS06420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TASI_RS06425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TASI_RS06430	COG0259	pyridoxamine-phosphate oxidase activity
TASI_RS06435	COG1858	cytochrome C peroxidase
TASI_RS06440	COG0009	L-threonylcarbamoyladenylate synthase
TASI_RS06445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TASI_RS06455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TASI_RS06465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TASI_RS06470	COG0126	phosphoglycerate kinase activity
TASI_RS06475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TASI_RS06480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TASI_RS06485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TASI_RS06500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TASI_RS06525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TASI_RS06530	COG0343	queuine tRNA-ribosyltransferase activity
TASI_RS06535	COG1862	Preprotein translocase
TASI_RS06540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TASI_RS06545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TASI_RS06550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TASI_RS06555	COG1702	phosphate starvation-inducible protein PhoH
TASI_RS06560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TASI_RS06590	COG4172	Belongs to the ABC transporter superfamily
TASI_RS06595	COG0747	negative chemotaxis
TASI_RS06600	COG0601	transmembrane transport
TASI_RS06605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TASI_RS06620	COG1446	asparaginase
TASI_RS06625	COG0328	RNA-DNA hybrid ribonuclease activity
TASI_RS06635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TASI_RS06640	COG1388	LysM domain
TASI_RS06640	COG0741	lytic transglycosylase activity
TASI_RS06655	COG0307	riboflavin synthase, alpha
TASI_RS06660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TASI_RS06660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TASI_RS06665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TASI_RS06670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TASI_RS06675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TASI_RS06680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TASI_RS06685	COG0316	Belongs to the HesB IscA family
TASI_RS06695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TASI_RS06700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TASI_RS06705	COG0312	modulator of DNA gyrase
TASI_RS06715	COG0400	carboxylic ester hydrolase activity
TASI_RS06720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TASI_RS06735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TASI_RS06745	COG2264	protein methyltransferase activity
TASI_RS06750	COG0439	Biotin carboxylase
TASI_RS06755	COG0511	ligase activity, forming carbon-carbon bonds
TASI_RS06760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TASI_RS06770	COG0795	lipopolysaccharide-transporting ATPase activity
TASI_RS06785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TASI_RS06790	COG0540	Belongs to the ATCase OTCase family
TASI_RS06795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TASI_RS06800	COG1678	Uncharacterized ACR, COG1678
TASI_RS06805	COG1773	rubredoxin
TASI_RS06810	COG0352	thiamine-phosphate diphosphorylase activity
TASI_RS06815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TASI_RS06820	COG0513	Belongs to the DEAD box helicase family
TASI_RS06830	COG0617	tRNA 3'-terminal CCA addition
TASI_RS06840	COG2879	small protein
TASI_RS06845	COG1966	Carbon starvation protein
TASI_RS06855	COG3976	FMN-binding domain protein
TASI_RS06855	COG1053	succinate dehydrogenase
TASI_RS06880	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TASI_RS06885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TASI_RS06890	COG1560	Kdo2-lipid A biosynthetic process
TASI_RS06895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TASI_RS06900	COG0708	Exodeoxyribonuclease III
TASI_RS06910	COG2223	nitrite transmembrane transporter activity
TASI_RS06915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TASI_RS06920	COG3245	cytochrome
TASI_RS06960	COG4566	intracellular signal transduction
TASI_RS06975	COG3258	Cytochrome c
TASI_RS06980	COG1858	cytochrome C peroxidase
TASI_RS07020	COG3152	Membrane
TASI_RS07030	COG0625	glutathione transferase activity
TASI_RS07035	COG2857	Cytochrome c1
TASI_RS07040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TASI_RS07045	COG0723	plastoquinol--plastocyanin reductase activity
TASI_RS07050	COG1970	mechanosensitive ion channel activity
TASI_RS07065	COG0805	protein transport
TASI_RS07070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TASI_RS07075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TASI_RS07080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TASI_RS07085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TASI_RS07095	COG0842	Transport permease protein
TASI_RS07100	COG1131	(ABC) transporter
TASI_RS07110	COG2853	Lipoprotein
TASI_RS07115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TASI_RS07120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TASI_RS07125	COG1127	ABC transporter
TASI_RS07130	COG0758	DNA mediated transformation
TASI_RS07135	COG0242	peptide deformylase activity
TASI_RS07140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TASI_RS07145	COG1253	flavin adenine dinucleotide binding
TASI_RS07165	COG0629	single-stranded DNA binding
TASI_RS07170	COG2814	Major facilitator Superfamily
TASI_RS07190	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TASI_RS07200	COG0019	diaminopimelate decarboxylase activity
TASI_RS07210	COG1965	Belongs to the frataxin family
TASI_RS07215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TASI_RS07220	COG1333	cytochrome c biogenesis protein
TASI_RS07230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TASI_RS07240	COG4232	protein-disulfide reductase activity
TASI_RS07250	COG0786	glutamate:sodium symporter activity
TASI_RS07255	COG0010	Belongs to the arginase family
TASI_RS07260	COG0203	ribosomal protein L17
TASI_RS07265	COG0202	RNA polymerase activity
TASI_RS07270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TASI_RS07275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TASI_RS07280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TASI_RS07290	COG0201	protein transport
TASI_RS07295	COG0200	Binds to the 23S rRNA
TASI_RS07300	COG1841	ribosomal large subunit assembly
TASI_RS07305	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TASI_RS07310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TASI_RS07315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TASI_RS07320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TASI_RS07325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TASI_RS07330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TASI_RS07335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TASI_RS07340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TASI_RS07350	COG2056	Na+-H+ antiporter family
TASI_RS07355	COG2056	Na+-H+ antiporter family
TASI_RS07360	COG2132	Multicopper oxidase
TASI_RS07375	COG2217	Heavy metal translocating P-type atpase
TASI_RS07405	COG1373	ATPase (AAA superfamily
TASI_RS07425	COG5295	Hep Hag repeat protein
TASI_RS07425	COG5295	Hep Hag repeat protein
TASI_RS07425	COG5295	Hep Hag repeat protein
TASI_RS07440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TASI_RS07445	COG0255	Belongs to the universal ribosomal protein uL29 family
TASI_RS07450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TASI_RS07455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TASI_RS07460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TASI_RS07465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TASI_RS07470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TASI_RS07475	COG0089	rRNA binding
TASI_RS07480	COG0088	Forms part of the polypeptide exit tunnel
TASI_RS07485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TASI_RS07490	COG1322	Protein conserved in bacteria
TASI_RS07505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TASI_RS07510	COG0051	transcription antitermination factor activity, RNA binding
TASI_RS07515	COG1132	(ABC) transporter
TASI_RS07520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TASI_RS07525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TASI_RS07530	COG0049	tRNA binding
TASI_RS07535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TASI_RS07545	COG2301	Belongs to the HpcH HpaI aldolase family
TASI_RS07555	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
TASI_RS07560	COG1960	acyl-CoA dehydrogenase activity
TASI_RS07580	COG3313	Fe-S protein
TASI_RS07585	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TASI_RS07595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TASI_RS07610	COG0010	Belongs to the arginase family
TASI_RS07615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TASI_RS07620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TASI_RS07625	COG0085	RNA polymerase activity
TASI_RS07630	COG0222	ribosome binding
TASI_RS07635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TASI_RS07640	COG0081	regulation of translation
TASI_RS07645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TASI_RS07665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TASI_RS07690	COG1475	DNA binding
TASI_RS07695	COG1192	Involved in chromosome partitioning
TASI_RS07700	COG0357	Ribosomal RNA small subunit methyltransferase G
TASI_RS07705	COG0445	tRNA wobble uridine modification
TASI_RS07710	COG0537	adenosine 5'-monophosphoramidase activity
TASI_RS07720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TASI_RS07725	COG0594	ribonuclease P activity
TASI_RS07730	COG0230	Belongs to the bacterial ribosomal protein bL34 family